The International Journal Of Angiology[JOURNAL]
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200 papers
Coronary Artery Bypass Grafting: A Review of Short- and Long-Term Outcomes.
Adeyemi A, Berman L, Staroselsky M … +4 more , Cordero D, Hai O, Makaryus AN, Zeltser R
Int J Angiol · 2025 Dec · PMID 41210672 · Full text
Coronary artery bypass grafting (CABG) remains a cornerstone in the management of complex coronary artery disease (CAD), offering significant improvements in both survival and quality of life. This review evaluates the s...
Coronary artery bypass grafting (CABG) remains a cornerstone in the management of complex coronary artery disease (CAD), offering significant improvements in both survival and quality of life. This review evaluates the short- and long-term outcomes associated with CABG. Despite its benefits, CABG carries perioperative complications, including atrial fibrillation, acute kidney injury, stroke, and surgical site infection. While early mortality rates, including in-hospital and 30-day outcomes, are comparable to those observed with percutaneous coronary intervention (PCI), long-term data often favor CABG in specific patient populations. Multiple studies have demonstrated superior long-term survival with CABG over PCI in patients with multivessel disease, left main CAD, and comorbid conditions such as diabetes mellitus. Perioperative morbidity and mortality are significantly influenced by patient-specific risk factors, such as advanced age, female sex, reduced ejection fraction, and elevated biomarkers (e.g., troponin, NT-proBNP, C-reactive protein). Since its introduction in the 1960s, CABG techniques have evolved with off-pump and minimally invasive approaches offering reduced hospital length of stay, shorter intensive care unit duration, and lower transfusion requirements, while maintaining comparable safety and efficacy to conventional on-pump surgery. In addition, graft selection is an important determinant of long-term success of CABG. In conclusion, CABG continues to be a highly effective revascularization strategy. Surgical technique, graft type, and careful patient selection remain essential to optimizing both perioperative safety and long-term outcome.
Invasive Endotyping of Angina Pectoris with Nonobstructive Coronary Arteries.
Gašpárková V, Adlová R, Ošťádal P … +2 more , Hájek P, Kala P
Int J Angiol · 2025 Dec · PMID 41210671 · Full text
Patients with chest pain are frequently diagnosed with angina pectoris with nonobstructive coronary arteries (ANOCA). The pathophysiology mainly involves the following mechanisms: structural or functional impairment of t...
Patients with chest pain are frequently diagnosed with angina pectoris with nonobstructive coronary arteries (ANOCA). The pathophysiology mainly involves the following mechanisms: structural or functional impairment of the microcirculation, functional impairment of the epicardial arteries, or a combination of both. This review describes the diagnosis of ANOCA, focusing on comprehensive coronary functional testing, resulting in more accurate endotyping and subsequent targeted treatment. It also determines the theoretical basis and practical aspects with graphic examples of the examination.
The Pathophysiology of Coronary Artery Disease.
Staroselsky M, Materia A, Damera RR … +4 more , Berman L, Hai O, Zeltser R, Makaryus AN
Int J Angiol · 2025 Dec · PMID 41210670 · Full text
Cardiovascular disease is among the most prevalent and morbid conditions worldwide. Coronary artery disease (CAD) is an important cause of cardiovascular disease and can range from mild to fatal conditions. There have be...
Cardiovascular disease is among the most prevalent and morbid conditions worldwide. Coronary artery disease (CAD) is an important cause of cardiovascular disease and can range from mild to fatal conditions. There have been advancements within the field of cardiology to help serve patients and improve outcomes related to CAD. A key aspect of this is a fundamental understanding of the pathophysiology of CAD and applying it in multiple disciplines. Clinicians are better equipped to manage their patients and come up with focused treatment plans once they have a solid foundation of the disease. In this review, we aim to highlight the important pathophysiological mechanisms behind CAD to help aid clinician decision-making and foster future advancements to continue to improve outcomes.
Medical Management of Coronary Artery Disease: An Update.
Hullon D, Bilal M, Shammas NW
Int J Angiol · 2025 Dec · PMID 41210669 · Full text
Chronic coronary artery disease (CAD) remains a leading cause of global morbidity and mortality, necessitating a nuanced approach to long-term management. While revascularization strategies play a crucial role in select...
Chronic coronary artery disease (CAD) remains a leading cause of global morbidity and mortality, necessitating a nuanced approach to long-term management. While revascularization strategies play a crucial role in select high-risk patients, optimal medical therapy (OMT) is the foundation of care for most individuals with stable disease. This review critically appraises contemporary pharmacological strategies for CAD, integrating the latest information from randomized trials and guideline-directed recommendations. Antihypertensive therapy, particularly renin-angiotensin system inhibitors and beta-blockers, remains central to reducing myocardial workload and preventing adverse cardiovascular events. Lipid-lowering agents, including high-intensity statins, ezetimibe, PCSK9 inhibitors, and inclisiran, have redefined risk stratification by demonstrating incremental reductions in low-density lipoprotein and atherosclerotic progression and event recurrence. The emergence of novel antidiabetic agents-SGLT2 inhibitors and GLP-1 receptor agonists-has expanded the therapeutic landscape, offering cardioprotective benefits independent of glycemic control. Additionally, the growing recognition of inflammation as a driver of CAD progression has led to the exploration of anti-inflammatory agents such as colchicine and interleukin-1 beta inhibitors. Landmark trials, including COURAGE, ISCHEMIA, and FREEDOM, reaffirm the noninferiority of OMT to revascularization in stable CAD, underscoring the need for an individualized approach. Future directions encompass precision medicine, artificial intelligence-driven risk stratification, and gene-based interventions, which may redefine therapeutic paradigms in CAD management.
Revascularization in Stable Coronary Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sultana N, Ha FJ, White A … +2 more , Brown AJ, Nerlekar N
Int J Angiol · 2025 Dec · PMID 41210668 · Full text
The optimal management strategy for stable coronary artery disease (CAD) remains contentious. While revascularization benefits acute coronary syndromes, its role in stable CAD compared with medical therapy (MT) is less c...
The optimal management strategy for stable coronary artery disease (CAD) remains contentious. While revascularization benefits acute coronary syndromes, its role in stable CAD compared with medical therapy (MT) is less clear. This systematic review and meta-analysis evaluated the safety and efficacy of coronary revascularization (percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG]) versus MT in patients with stable CAD. A systematic search identified randomized trials comparing revascularization with optimal MT in stable CAD. Trials included documented CAD via angiography and excluded acute coronary syndromes. The primary safety endpoint was all-cause mortality, non-fatal myocardial infarction (MI), and stroke. The primary efficacy endpoint also included unplanned revascularization, cardiac hospitalization, and major bleeding. The secondary endpoint included the percentage free from angina. Relative risk (RR) was calculated using random-effects models. Ten trials with 14,171 participants were included. There was no difference in the primary safety endpoint (RR 0.96 [0.90-1.03], = 0.23). The primary efficacy endpoint favored revascularization (RR 0.81 [0.69-0.96], = 0.01), primarily driven by unplanned revascularization (RR 0.5 [0.29-0.85], = 0.01), though with increased procedural MI risk (RR 2.21 [1.44-3.39], < 0.001). More patients had freedom from angina with revascularization compared with MT (71.8% vs. 62.9%, < 0.001). In stable CAD, initial revascularization did not improve outcomes for the primary safety endpoint; however, it did reduce unplanned revascularization compared with MT. More patients had freedom from angina in the revascularization arm, at the cost of increased procedural MI. Decision regarding optimal management strategy for stable CAD remains a patient-centered discussion, recognizing the largely symptomatic rather than prognostic benefit that patients derive from early revascularization.
Circulatory Support for High-Risk Coronary Artery Bypass Grafting and Coronary Interventions: Where is the Evidence?
Gorton AJ, Keshavamurthy S
Int J Angiol · 2025 Dec · PMID 41210667 · Full text
Coronary artery disease remains the leading cause of morbidity and mortality worldwide. Patients with ischemic cardiomyopathy or other high-risk features undergoing coronary artery bypass grafting (CABG) or percutaneous...
Coronary artery disease remains the leading cause of morbidity and mortality worldwide. Patients with ischemic cardiomyopathy or other high-risk features undergoing coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) present significant perioperative challenges due to elevated procedural risks. Mechanical circulatory support (MCS) devices such as the intra-aortic balloon pump, Impella devices, and venoarterial extracorporeal membrane oxygenation have increasingly been used to mitigate these risks. This review aims to evaluate the evidence supporting the use of temporary MCS in high-risk CABG and PCI, define high-risk patient populations, and compare device-specific benefits, risks, and clinical outcomes.
A Review of Indications and Guidelines of Chronic Total Occlusion Revascularization.
Kotev S, Sami F, Malangu B
Int J Angiol · 2025 Dec · PMID 41210666 · Full text
Chronic total occlusion (CTO), affecting 18 to 30% of coronary artery disease patients undergoing angiography, is linked to refractory angina, reduced left ventricular function, and increased arrhythmia risk. This articl...
Chronic total occlusion (CTO), affecting 18 to 30% of coronary artery disease patients undergoing angiography, is linked to refractory angina, reduced left ventricular function, and increased arrhythmia risk. This article synthesizes indications, evidence, and guidelines for CTO revascularization, focusing on percutaneous coronary intervention (PCI). CTO PCI achieves over 85% success rates in expert hands, with randomized controlled trials showing improved symptom relief and quality of life, though mortality or ventricular function benefits remain unproven. The 2021 ACC/AHA/SCAI and 2018 ESC/EACTS guidelines recommend CTO PCI for refractory angina, emphasizing operator expertise and shared decision-making. Controversies persist regarding prognostic benefits and patient selection. Ongoing trials aim to clarify these issues. This review equips clinicians with a framework to navigate CTO management, balancing evidence and patient-centered care.
Coronary Plaque Regression: A Review of the Role of Lipid-Lowering Agents.
Adhikari A, Wutawunashe C, Kim M … +1 more , Kodra A
Int J Angiol · 2025 Dec · PMID 41210665 · Full text
The burden of coronary artery disease (CAD) globally is substantial. Lipid-lowering therapies (LLT) significantly reduce the morbidity and mortality associated with CAD. The advent of more sophisticated imaging modalitie...
The burden of coronary artery disease (CAD) globally is substantial. Lipid-lowering therapies (LLT) significantly reduce the morbidity and mortality associated with CAD. The advent of more sophisticated imaging modalities of the coronary arteries, including intravascular ultrasound, optical coherence tomography, and coronary computed tomography angiography with calcium scoring, has allowed for evaluation of changes in plaque composition and volume as surrogates of plaque regression. LLTs, particularly statins and proprotein convertase subtilisin/kexin type 9 inhibitors, are effective in reducing low-density lipoprotein cholesterol and reducing cardiovascular mortality. This review synthesizes the evidence on the efficacy of various LLT agents in promoting plaque regression.
Outcome of Redo Endovascular Interventions in Cases of Infra-inguinal Arterial Occlusive Disease.
Fekry KM, Balbaa S, Saeed A … +1 more , Shaker AA
Int J Angiol · 2025 Sep · PMID 40771295 · Full text
The aim was to assess the outcomes of different redo endovascular interventions in terms of wound healing and limb salvage within 6 months. From April 2024 to October 2024, a prospective clinical study was carried out on...
The aim was to assess the outcomes of different redo endovascular interventions in terms of wound healing and limb salvage within 6 months. From April 2024 to October 2024, a prospective clinical study was carried out on 56 patients who presented with chronic limb-threatening ischemia (CLTI) after previous peripheral endovascular intervention 6 months to 1 year earlier. Regarding technical success, restored linear blood flow from common femoral artery (CFA) to foot was higher in stenting and drug-coated balloon (DCB) than plain old balloon angioplasty (POBA) ( value = 0.032 and 0.033 respectively). Restoration of pedal pulse was statistically higher in DCB than in stenting ( value = 0.006) and higher in stenting than POBA ( value = 0.003). Wound healing at time frame of 3 months after the operation was statistically higher in DCB than POBA and stenting ( value = 0.002 and 0.007 respectively) and higher in stenting than POPA ( value = 0.033). Regarding amputation-free survival, above ankle amputation within 6 months of follow-up was lower in stenting and DCB than POBA ( value = 0.016 and 0.018 respectively) and there was no statistical difference between stenting and DCB ( value = 0.166). Stenting and DCBs have demonstrated a superior ability than POBA to restore linear blood flow from the CFA to the foot, leading to better amputation-free survival rates, including a decreased likelihood of above ankle amputation within the first 6 months of follow-up. When it comes to wound healing and sustaining limb-based patency, DCB angioplasty has shown better performance compared with stenting and POBA.
Mechanical Thrombectomy and Catheter-Directed Lysis in Treating Intermediate-Risk Pulmonary Embolization: 30-Day Outcome.
Shammas NW, Sharis W, Mankarious G … +5 more , Inala Y, Janes MJ, Shammas G, Jones-Miller S, Voelliger C
Int J Angiol · 2025 Sep · PMID 40771293 · Full text
Intermediate risk pulmonary embolism (IRPE) is defined as dilatation of the right ventricular (RV) and evidence of myocardial necrosis with stable hemodynamics in the setting of acute PE. The differences in performance a...
Intermediate risk pulmonary embolism (IRPE) is defined as dilatation of the right ventricular (RV) and evidence of myocardial necrosis with stable hemodynamics in the setting of acute PE. The differences in performance among the various devices in treating IRPE remain unclear. We reviewed consecutive patients treated at 2 medical centers between January 1, 2019, and December 31, 2022, using PMC devices (FlowTriever [Inari Medical] or Ekos [Boston Scientific]). Demographics, clinical, procedural variables, in-hospital complications, and 30-day outcomes were recorded from patients' medical records. Descriptive analyses were performed. The study's primary endpoint was the mean change in the RV/LV ratio. Safety endpoints included procedural complications 30-day mortality and major bleeding. 97 consecutive patients (43 FlowTriever, 54 Ekos) were included. The mean age was 64.16 ± 13.37 years. When compared with pretreatment, PMC reduced significantly the RV/LV ratio (0.55 ± 0.49, 95% CI: 0.40, 0.71, < 0.0001) and PA pressures (17.98 ± 14.72 mm Hg, 95% CI:10.88, 25.07, < 0.0001) with no differences seen between the FlowTriever and Ekos. At 30-day, all-cause mortality and major bleeding were 5.2 and 7.2%, respectively, and were similar between the FlowTriever and Ekos, respectively (4.7% vs. 5.6% ( = 0.935) and 7.0% vs. 7.4% ( = 0.935)). The Ekos, however, had a shorter procedure time, and less fluoroscopy and contrast use. PMC devices reduced significantly the RV/LV ratio and PA pressures when compared with the baseline. No differences were seen between the FlowTriever and Ekos. Thirty-day mortality and major bleeding were statistically similar between the two devices.
Left Ventricular Assist Device in the Management of Heart Failure: A Single-Center Experience.
Karem S, Malyala RSR, Saha S
Int J Angiol · 2025 Sep · PMID 40771292 · Full text
BACKGROUND: Heart failure is a prevalent health care issue in the United States. While most cases of heart failure can be managed medically, intractable cases benefit from a left ventricular assist device (LVAD). AIM: Th...
BACKGROUND: Heart failure is a prevalent health care issue in the United States. While most cases of heart failure can be managed medically, intractable cases benefit from a left ventricular assist device (LVAD). AIM: The aim of this study is to review the outcomes of LVAD therapy at the University of Kentucky. MATERIALS AND METHODS: Data received from University of Kentucky Hospital. We received Institutional Review Board approval to review patient records admitted for LVAD implantation from January 1, 2017, to December 31, 2021. RESULTS: After reviewing records, we had 127 eligible LVAD patients with an age range of 18 to 83 years, with 87% of recipients being white, 12.5% being black, 81% male, and 19% female. Results show the average length of admission for patients receiving LVAD is 41 days. Quality of life is reported using the New York Heart Association (NYHA) classification at follow-up, which shows 6 patients in Class I, 52 patients progressing to Class II, 21 patients to class III; other patients were deceased before discharge or did not go below class IV heart failure. Prior to 2021, there were 105 patients and 65 patients were alive at 2 years follow-up, and 18 out of 23 patients who received LVAD after 2021 are still living. For postoperative complications, 26% developed stroke, 24.4% developed gastrointestinal bleeding, 26% developed renal failure, 44.8% developed respiratory failure, 37% developed driveline infection, 14.2% developed right ventricular dysfunction/failure, and 20.4% developed an LVAD complication. CONCLUSION: LVAD has been implemented to manage advanced heart failure and improve quality of life.
Temporal Trends in Pulmonary Embolism Mortality Associated with COVID-19 in the United States: A 5-Year Retrospective Analysis.
Lippi G, Mattiuzzi C
Int J Angiol · 2025 Sep · PMID 40771291 · Full text
Coronavirus disease 2019 (COVID-19) has been strongly associated with thrombotic complications, particularly pulmonary embolism (PE). This study aims to analyze the real-world impact of COVID-19 on PE-related mortality i...
Coronavirus disease 2019 (COVID-19) has been strongly associated with thrombotic complications, particularly pulmonary embolism (PE). This study aims to analyze the real-world impact of COVID-19 on PE-related mortality in the United States over the first 5 years of the pandemic. We conducted a retrospective observational study using the CDC WONDER database, combining data on mortality from PE and COVID-19 using the 10th revision of the International Classification of Diseases (ICD-10) codes I26 (PE) and U07.1 (COVID-19). The analysis spanned from 2020 to 2024. We found a peak in COVID-19-associated PE deaths in 2021, with an estimated crude rate of 211 × 1,000 PE deaths. This rate progressively declined over the following years, being 141 × 1,000 in 2022, 44 × 1,000 in 2023, and 29 × 1,000 in 2024, respectively. The estimated crude rate for COVID-19-associated PE in the United States was 111 × 1,000 PE deaths throughout the 5-year period. The results of our study show that COVID-19 may have contributed to nearly one-tenth of all PE deaths throughout the first 5 years of the pandemic. Despite the gradual decline over the years since its peak in 2021, the still sustained mortality suggests ongoing thrombotic risks, especially impacting high-risk populations, emphasizing the need for continued vigilance and prevention of thrombotic complications in COVID-19 patients.
Comparison of Endoaortic Balloon Occlusion and Transthoracic Aortic Clamp for Minimally Invasive Cardiac Surgery: Systematic Review and Meta-analysis.
Naito N, Takagi H
Int J Angiol · 2025 Sep · PMID 40771290 · Full text
This meta-analysis aimed to compare short-term outcomes in patients undergoing minimally invasive cardiac surgery (MICS) using endoaortic balloon (EAB) and transthoracic aortic clamp (TAC) techniques. A comprehensive sea...
This meta-analysis aimed to compare short-term outcomes in patients undergoing minimally invasive cardiac surgery (MICS) using endoaortic balloon (EAB) and transthoracic aortic clamp (TAC) techniques. A comprehensive search of relevant databases was conducted through July 2024. Pooled results were calculated, and subgroup analyses of studies published during early and late eras were performed. Additionally, a meta-regression analysis based on the year of publication was conducted to assess potential influences on outcomes. The systematic review identified 17 non-randomized studies encompassing a total of 8,253 patients. In terms of intraoperative outcomes, no significant differences were observed in operation duration, aortic cross-clamp time, cardiopulmonary bypass time, or rates of sternotomy conversion and iatrogenic aortic dissection. However, subgroup analysis of early-era studies demonstrated significantly longer operation times in the EAB cohort ( = 0.03). Meta-regression analysis indicated that the standardized mean differences in cardiopulmonary bypass time between the two groups decreased in favor of EAB as publication years progressed ( = 0.01). For postoperative outcomes, no significant differences were found in postoperative stroke rate, the rate of reoperation for bleeding, or length of hospital stay. However, the EAB group had significantly lower rates of postoperative atrial fibrillation (OR = 0.82 [0.70-0.95], < 0.01) and short-term mortality (OR = 0.60 [0.39-0.92], = 0.04). This meta-analysis demonstrated that EAB is associated with perioperative outcomes comparable to TAC in select patients. The cumulative experience and evolution of techniques may have contributed to improved outcomes with EAB over time.
Unusual Incidence of Acute Type A Aortic Dissection during COVID-19.
Giammarino AT, Winalski J, Pupovac SS … +3 more , Manetta F, Sarmiento IC, Brinster DR
Int J Angiol · 2025 Sep · PMID 40771289 · Full text
Seasonal variations have been identified in the incidence of Stanford acute type A aortic dissection (ATAAD), and these have been only further impacted by the recent COVID-19 pandemic. We sought to examine the incidence...
Seasonal variations have been identified in the incidence of Stanford acute type A aortic dissection (ATAAD), and these have been only further impacted by the recent COVID-19 pandemic. We sought to examine the incidence and presentation of ATAAD during the initial height of the COVID-19 pandemic during the year 2020 and compare this with our pre-pandemic experience. A retrospective review was undertaken of all consecutive patients who had ATAAD repair between January 2014 and December 2020. The incidence and pattern of presentation during 2020 was compared with that of the prior 6 years. A total of 339 patients underwent ATAAD during the study period, 301 (88.8%) from 2014 to 2019 (pre-COVID-19) and 38 (11.2%) during 2020 (coincident with COVID-19). We found a marked decrease in the incidence of ATAAD during COVID-19 as compared to the aggregate of our prior experience. During the height of the COVID-19 pandemic, we witnessed significantly fewer patients presenting with ATAAD, presumably due to a combination of "lockdown" restrictions, perhaps coupled with reduced influenza activity in the population. This was followed by an unusual rebound in the incidence of ATAAD, a phenomenon not previously noted.
Prognostic Value of Right Ventricular Echocardiography on Mortality in Intermediate-Risk Hispanic Patients with Acute Pulmonary Embolism.
Kothari A, Dwivedi AK, Mukherjee D … +2 more , Rajachandran M, Nickel NP
Int J Angiol · 2025 Sep · PMID 40771287 · Full text
There is an underrepresentation of Hispanic patients in studies examining right ventricular (RV) function in acute pulmonary embolism (PE). Although the prognostic value of RV dysfunction in acute PE is well established,...
There is an underrepresentation of Hispanic patients in studies examining right ventricular (RV) function in acute pulmonary embolism (PE). Although the prognostic value of RV dysfunction in acute PE is well established, there is no generalized definition of RV dysfunction. In this study, our aim was to identify echocardiographic parameters that predict short-term mortality in Hispanic patients with intermediate-risk acute PE. This study aimed to determine clinical and echocardiographic predictors of mortality in Hispanic patients with intermediate-risk PE. We retrospectively studied a cohort of Hispanic patients with acute PE diagnosed on computed tomography angiography and classified as intermediate-risk based on either imaging findings or biomarker elevation. We identified 419 patients. The mean age was 58, and 53% were females. Forty (9.5%) patients died during the 30-day follow-up. Non-survivors had a higher Pulmonary Embolism Severity Index (PESI) score (101 ± 19.4, < 0.001), a higher incidence of diabetes, chronic kidney disease, end-stage renal disease, malignancy, and previous history of venous thromboembolism. On echocardiogram, non-survivors had an increased right ventricular end-diastolic area (32.7 ± 9 cm ), higher right ventricular to left ventricular ratio (RV/LV, 0.75 ± 0.15), elevated right ventricular systolic pressure (RVSP, 42.4 ± 8.24), reduced right ventricular fractional area change (RVFAC, 24.03 ± 7.6), and reduced lateral tricuspid annular peak systolic velocity (TR max Vel S', 9.39 ± 2.2). In Hispanic patients with acute intermediate-risk PE, increased RV afterload (RVSP), RV dilation (RVDa, RV/LV ratio), and reduced RV systolic function (tricuspid annular plane systolic excursion, S', RVFAC) are the most important predictors of poor short-term outcome.
Biomarkers for Postoperative Intimal Hyperplasia.
Yamamura M, Sakaguchi T, Tanaka H … +5 more , Watanabe KI, Uemura H, Sakashita Y, Teshima Y, Bungo M
Int J Angiol · 2025 Jun · PMID 40365158 · Full text
Interleukin-8 (IL-8) is a neutrophil chemotactic factor produced by vascular endothelial cells. This study aimed to evaluate whether the serum IL-8 level can be the biomarker for postoperative intimal hyperplasia in the...
Interleukin-8 (IL-8) is a neutrophil chemotactic factor produced by vascular endothelial cells. This study aimed to evaluate whether the serum IL-8 level can be the biomarker for postoperative intimal hyperplasia in the rat model. Sixteen male Lewis rats (mean weight: 501 ± 44 g) were subjected in this study. The right epigastric vein graft is interposed into the common femoral artery with 10-0 interrupted sutures, as previously described. Vein grafts from each group were stained with hematoxylin and eosin and Elastica Verhoeff's van Gieson's at 2 and 4 weeks postoperatively. Unoperated right epigastric veins were also examined as a Sham. In Group edaravone, free-radical scavenger, edaravone (Radicut , Mitsubishi Tanabe Pharma Corp., Osaka Japan) was administered, instead of saline. The initial areas of vein grafts were measured using computerized planimetry (NIH Image Ver. 1.61). Serum IL-8 levels were measured and compared using an unpaired -test. This study was approved by the Hyogo College of Medicine Animal Research Committee (No. 235). The average intimal area at 4 weeks in Control group was significantly increased compared with that of Sham group (0.43 ± 0.11 vs. 0.00 ± 0.00 mm , < 0.01). The average serum IL-8 levels at 4 weeks were also significantly increased, compared with that of Sham group (148 ± 6 vs. 53 ± 14 pg/mL, < 0.05). The serum IL-8 levels in Group edaravone were appeared to be suppressed but not significant (132 ± 24 pg/mL, = 0.72). It is very important to detect the biomarker such as the serum IL-8, before the establishment of postoperative intimal hyperplasia.
MicroRNA Profiling in Chronic Limb-Threatening Ischemia Their Role in Arteriogenesis.
Ismail MT, Setianto BY, Haryana SM … +1 more , Anggrahini DW
Int J Angiol · 2025 Jun · PMID 40365156 · Full text
Chronic limb-threatening ischemia (CLTI) represents poses a substantial threat with escalating mortality and amputation rates. Despite the existence of various clinical techniques for diagnosing CLTI, the role of microRN...
Chronic limb-threatening ischemia (CLTI) represents poses a substantial threat with escalating mortality and amputation rates. Despite the existence of various clinical techniques for diagnosing CLTI, the role of microRNAs (miRNAs) in arteriogenesis remains ambiguous. Comprehensive knowledge on miRNAs may facilitate the advancement of targeted therapy pertaining to the enhancement of collateral blood flow in obstructed vessels. Therefore, this study aimed at analyzing arteriogenesis-associated plasma miRNA profiles in patients with CLTI using gene expression. Samples were acquired from the collateral arteries (CA group, = 3) and the contralateral healthy limb (healthy artery; HA group, = 3) of a single set of patients with CLTI. The RNA extracted from the samples was assessed for concentration and purity. A normalization factor was used to address variations in analyte abundance and/or quality across the samples. Subsequently, individual RNA molecules were directly quantified and subjected to comparative analysis between the CA and HA groups to identify the miRNAs involved in arteriogenesis. The five arteriogenesis-related miRNAs exhibiting maximum upregulation were miR-301b-3p, miR-221-5p, miR-639, miR-34a-5p, and let-7a-5p, while the five most downregulated miRNAs included miR-151a-5p, miR-371a-5p, miR-651-5p, miR-510-5p, and miR-660-5p. Summarily, this study documented marked upregulation and downregulation of miRNAs associated with arteriogenesis in the collateral arteries of patients with CLTI as compared with their contralateral healthy limbs. Possible mechanisms involved, including the regulation of YAP/TAZ pathway, TGFBR3 mRNA, SIRT1 expression, and other processes have shown to be modulated by miRNAs fluctuations.
Aorta Rupture Due to Extracorporeal Shock Wave Lithotripsy: A Rare Case Report.
Stagkoglou C, Kaperonis E, Papavasileiou V
Int J Angiol · 2025 Jun · PMID 40365154 · Full text
Since the 1980s, extracorporeal shock wave lithotripsy (ESWL) has been the treatment of choice for most urinary calculi. It is generally considered a safe method with a few complications involving the vascular system, am...
Since the 1980s, extracorporeal shock wave lithotripsy (ESWL) has been the treatment of choice for most urinary calculi. It is generally considered a safe method with a few complications involving the vascular system, among others. There are only a few literature reports of aortic rupture after ESWL and these mainly concern abdominal aortic aneurysms and rarely, severe atherosclerotic aorta. We report the case of a 67-year-old man with a rupture of a longitudinally and circumferentially calcified abdominal aorta and pseudoaneurysm formation following ESWL which he underwent a few days before the symptoms started. He reported urgently to our department after a recurrence of severe abdominal and lumbar pain. An endovascular treatment attempt with stent graft implantation was made initially but since the perforation did not seal, open surgery with stent removal, hematoma excision, and an aortobifemoral bypass was decided. He died 23 days later because of acute myocardial infarction. We believe that it is possible for severely calcified vessels to rupture through ESWL, and great care should be taken in these patients for symptoms or signs of retroperitoneal hematoma after the procedure.
Endovascular Aneurysm Repair (EVAR) in Rupture of the Infrarenal Abdominal Aortic Aneurysm (AAA) with Severe Neck Angulation in Conscience of National Health Coverage in Tertiary Referral Hospital in Indonesian: Case Report.
Nugroho NT, Primananda R, Javier RM … +2 more , Fachriza I, Suhartono R
Int J Angiol · 2025 Jun · PMID 40365147 · Full text
An aortic aneurysm is a condition with focal dilation of 50% or more over the normal aortic diameter. The most frequent form of aortic aneurysms is infrarenal. Endovascular aortic aneurysm repair is a valid treatment for...
An aortic aneurysm is a condition with focal dilation of 50% or more over the normal aortic diameter. The most frequent form of aortic aneurysms is infrarenal. Endovascular aortic aneurysm repair is a valid treatment for treating patients with abdominal aortic aneurysm. Abdominal aortic aneurysms (AAAs) are electively repaired to prevent rupture. We present a case of an elderly man with an impending rupture of intraluminal infrarenal AAA with bilateral common iliac arteries aneurysms. Overall, the patient had completed the procedure and made a good postoperative recovery with fully coverage of Indonesian national health insurance.
Comment on Clinical Presentation and Risk Stratification of Pulmonary Embolism.
Glazier HA, Kaki A
Int J Angiol · 2025 Jun · PMID 40365143 · Full text
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