Gao Y, Guo LJ, Zhang MT
… +4 more, Su JX, Liu XM, Zhang B, Wang HD
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942325
·
Publisher ↗
An 8-year-old girl with growth failure and multisystem involvement was admitted to the Institute of Medical Genetics at Henan Provincial People's Hospital in May 2022. She presented with craniofacial abnormalities, langu...An 8-year-old girl with growth failure and multisystem involvement was admitted to the Institute of Medical Genetics at Henan Provincial People's Hospital in May 2022. She presented with craniofacial abnormalities, language delay, and psychomotor retardation, suggestive of Sensenbrenner syndrome. Whole-exome sequencing and Sanger sequencing performed on the family revealed that the proband carried two novel compound heterozygous mutations in the WDR19 gene: c.1574A>G (p.Asn525Ser) and c.196G>A (p.Gly66Arg), inherited from her father and mother, respectively. Bioinformatics analysis indicated that the amino acids encoded by these two variants are highly conserved across multiple species and that these mutations may alter the secondary and tertiary structures of the protein, potentially affecting its phosphorylation and glycosylation properties. These findings suggest that these variants likely constitute the genetic basis underlying the clinical manifestations observed in the proband. The present case expands the known mutation spectrum of the WDR19 gene, provides new evidence for the diagnosis of Sensenbrenner syndrome.
Zhang JH, Zhang H, Ge WL
… +3 more, Yu HY, Hu C, Chen S
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942324
·
Publisher ↗
This study aimed to identify mutations in the SLC12A3 gene and investigate their role in the pathogenesis of Gitelman syndrome. Sanger sequencing of the SLC12A3 gene was performed using samples from a patient clinically...This study aimed to identify mutations in the SLC12A3 gene and investigate their role in the pathogenesis of Gitelman syndrome. Sanger sequencing of the SLC12A3 gene was performed using samples from a patient clinically suspected of having Gitelman syndrome, who was admitted to the Department of Endocrinology and Metabolism at Shanghai Fengxian District Central Hospital in August 2024. Upon identification of mutations, the relevant exons were sequenced in her first-degree relatives. Functional predictions of the protein were made using CADD, DANN, MetaSVM, Polyphen2, SIFT, and M-CAP software. A previously unreported missense variant, NM_000339:c.704C>A (p.Thr235Lys), located in exon 16 of SLC12A3, was identified in homozygosity in the proband and in heterozygosity in her daughter. This mutation was absent in all control individuals. Multiple prediction tools consistently indicated that the mutation likely disrupts gene/protein structure or function. The c.704C>A mutation in exon 16 of SLC12A3 is a novel pathogenic variant contributing to the development of Gitelman syndrome.
Yang MX, Li B, Wang JX
… +5 more, Guo ZX, Zhou HX, Wang YJ, Gu WJ, Mu YM
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942323
·
Publisher ↗
This article reports three cases of primary aldosteronism (PA) with spontaneous remission following withdrawal of long-term mineralocorticoid receptor antagonist (MRA) therapy at Department of Endocrinology, the First Me...This article reports three cases of primary aldosteronism (PA) with spontaneous remission following withdrawal of long-term mineralocorticoid receptor antagonist (MRA) therapy at Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital between May 2018 and December 2024. The cohort included 1 male and 2 females, aged 42 to 60 years, with a hypertension duration of 6-27 years. All patients met the diagnostic criteria for PA outlined in the Expert Consensus on the Diagnosis and Treatment of Primary Aldosteronism (2024 edition) from the Chinese Society of Endocrinology. After 3-5 years of MRA treatment followed by gradual dose reduction until complete discontinuation, all three patients maintained normokalemia (4.1-4.6 mmol/L) during 12 months of follow-up. Two patients discontinued all antihypertensive medications, while one remained on monotherapy, with blood pressure maintained at 100-127/56-80 mmHg (1 mmHg=0.133 kPa). The aldosterone-to-renin ratio (ARR) normalized (<3.7) in all cases. A literature review suggested that ARR normalization occurs in 5%~80% of patients with PA following MRA withdrawal, indicating that spontaneous remission of PA is not uncommon. Regular re-evaluation every 1-2 years is recommended for PA patients receiving medical therapy. In eligible cases, dose reduction or discontinuation may be considered under close monitoring to avoid lifelong medication.
Guan X, Yin JH, Cao XY
… +8 more, Du ZH, Liu XF, Zhang RJ, Lyu B, Wang XH, Bian Y, Guo ZW, Wang J
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942322
·
Publisher ↗
To compare the incidence of in-stent restenosis (ISR) among four self-expanding intracranial stents (Enterprise, Neuroform EZ, Solitaire, and Wingspan) and to explore the associated risk factors. A retrospective analysi...To compare the incidence of in-stent restenosis (ISR) among four self-expanding intracranial stents (Enterprise, Neuroform EZ, Solitaire, and Wingspan) and to explore the associated risk factors. A retrospective analysis was performed on 257 patients with symptomatic intracranial arterial stenosis who underwent stent implantation at the First Medical Center of PLA General Hospital between January 2018 and December 2023. All patients completed angiographic follow-up at 6-12 months postoperatively. Patients were divided into the ISR group ( = 58) and non-ISR group ( = 199). Baseline characteristics, lesion features, and lipid profiles were collected. Univariate and multivariate logistic regression analyses were used to determine independent predictors of ISR. There were no significant differences in ISR incidence among the four stent types or across different vascular regions (>0.05). The ISR rate was relatively high in the intracranial internal carotid artery (C5-C7) (28.3%). Multivariate analysis demonstrated that elevated low-density lipoprotein cholesterol (LDL-C) (=2.148, =0.030), severe preoperative stenosis (≥90%) (=3.987, =0.020), and postoperative residual stenosis≥30% (=6.634, =0.001) were independent risk factors for ISR. ISR following implantation of self-expanding intracranial stents is associated with elevated LDL-C levels, severe preoperative stenosis, and high residual stenosis. Optimizing lipid control and minimizing residual stenosis, especially in lesions of the intracranial internal carotid artery, may help reduce the risk of restenosis.
Sang YZ, Lei FF, Xiao XH
… +5 more, Ning YP, Pan H, Ye CX, Li HX, Lu HN
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942321
·
Publisher ↗
To investigate the clinical characteristics of hospitalized patients with thunderstorm asthma. Clinical data from 125 patients with thunderstorm asthma admitted to four tertiary hospitals in Lanzhou City after a thunder...To investigate the clinical characteristics of hospitalized patients with thunderstorm asthma. Clinical data from 125 patients with thunderstorm asthma admitted to four tertiary hospitals in Lanzhou City after a thunderstorm on September 19, 2024, were retrospectively collected. Statistical methods, including the chi-square test and independent samples -test among others were used to evaluate demographic information, clinical manifestations, medical history, pulmonary function, laboratory findings, and prognosis. Among the 125 patients, 78 were male and 47 were female, with a median age of 35 years. The cohort was categorized into three age groups:<14 years (=43), 14-60 years (=52), and>60 years (=30), and further divided into non-severe (=67) and severe (58) groups. The primary clinical manifestations included chest tightness (77.6%, 97/125) and cough (64.8%, 81/125). Regarding medical history, 63 patients reported an Artemisia/pollen allergy, 51 had allergic rhinitis, and 22 had bronchial asthma. Severe obstructive ventilation dysfunction was observed in 19 cases (25.0%, 19/76). Serum total IgE was elevated in 73 cases (91.3%, 73/80), with the highest allergen-positive rate reported for Artemisia (81.1%, 60/74). Pairwise comparisons indicated that the proportion of severe cases was significantly higher in males than in females [53.8% (42/78) vs. 34.0% (16/47), =4.63, =0.031]. By age, the proportion of severe cases in the >60 group was significantly higher than that in the 14-60 [70.0% (21/30) vs. 44.2% (23/52), =7.84, =0.005] and <14 [32.6% (14/43), =12.36, <0.001] age groups. Furthermore, the proportion of severe cases was significantly higher in patients without than in those with a history of asthma [50.5% (52/103) vs. 27.3% (6/22), =3.93, =0.047]. The length of hospital stay in the severe group was significantly longer than that in the non-severe group [(8.3±2.6) d vs. (5.4±2.1) d, =6.90, <0.001]. Within the severe cohort, 10.3% (6/58) required non-invasive ventilation, and all patients achieved a favorable prognosis. The majority of hospitalized patients with thunderstorm asthma were male, with the highest prevalence observed in the 14-60 age group. Most patients had a history of Artemisia/pollen allergy and allergic rhinitis. Male sex, advanced age (>60 years), and the absence of asthma history were identified as high-risk factors for developing severe conditions. Health education for these high-risk populations should be prioritized.
Wang YR, Lin C, Lyu F
… +4 more, Wei ZH, Li CW, Cai XL, Ji LN
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942320
·
Publisher ↗
To evaluate the applicability of a pathophysiology-based obesity phenotyping approach in Chinese patients with obesity and characterize the clinical features of different obesity phenotypes. In this cross-sectional stud...To evaluate the applicability of a pathophysiology-based obesity phenotyping approach in Chinese patients with obesity and characterize the clinical features of different obesity phenotypes. In this cross-sectional study, patients with obesity (body mass index ≥28 kg/m) were recruited from the obesity and weight management clinic of Peking University People's Hospital between December 2023 and November 2024. Data were collected regarding demographics, body composition, hunger perception [Visual Analogue Scale (VAS)], depressive status (Hospital Anxiety and Depression Scale), basal metabolic rate, and metabolic parameters. Using pre-established cut-off values derived from previous studies, participants were categorized into brain hunger, gastrointestinal hunger, emotional hunger, hypometabolic, or untyped phenotypes. The Kruskal-Wallis test and other methods were used for comparisons among multiple groups, and the Bonferroni correction applied for multiple comparisons. Among the 900 patients [mean age (34.9±8.3) years; 61.3% female, 552/900], the brain hunger phenotype (22.1%, 199/900) exhibited the highest 30-min VAS score [ (, ), 33 (21, 43)], significantly exceeding that of the gastrointestinal hunger phenotype [19 (0, 30), all <0.05]. The gastrointestinal hunger phenotype (43.9%, 395/900) demonstrated a significantly higher 2-hour VAS score [41 (30, 60)] than either the emotional hunger [20 (0, 41)] or hypometabolic [20 (0, 40)] phenotype (both <0.05). The emotional hunger phenotype (34.1%, 307/900) had the highest depression score [8 (7, 9)], significantly exceeding those of the brain hunger [4 (2, 7)] and gastrointestinal hunger [4 (2, 7)] groups; its fasting C-peptide level [1.21 (0.95, 1.52) nmol/L] was significantly higher than those of the brain hunger [1.11 (0.84, 1.38) nmol/L] and gastrointestinal hunger [1.11 (0.85, 1.48) nmol/L] groups (all <0.05). The hypometabolic phenotype (54.2%, 488/900) exhibited the lowest ratio of measured basal metabolic rate to predicted basal energy expenditure [82% (80%, 84%)], which was significantly lower than that of the brain hunger phenotype [86% (82%, 89%); all <0.05]. This phenotype had the highest body mass index [34.22 (31.50, 37.38) kg/m], which was significantly higher than that of the brain hunger phenotype [32.21 (30.20, 35.37) kg/m; all <0.05]. Furthermore, uric acid levels in the hypometabolic group [431 (370, 496) μmol/L] were significantly higher than those in the gastrointestinal hunger [405 (343, 473) μmol/L] and emotional hunger [413 (353, 476) μmol/L] phenotypes (both <0.05); this group also had the highest body fat percentage [44.5% (39.3%, 48.5%)] and visceral fat level [20 (18, 20)] among all phenotypes (all <0.05). Additionally, 16.3% (147/900) of patients remained untyped, while 49.0% (441/900) presented with multiple phenotypes. The pathophysiology-based phenotyping approach can identify subtypes with different clinical characteristics among Chinese patients with obesity. Each phenotype exhibits distinct characteristics in hunger regulation, emotional status, energy metabolism, and body composition.
MRI Intervention Expert Working Group, Interventional Physicians Branch, Chinese Medical Doctor Association, Interventional Minimally Invasive Therapy Specialized Committee, Chinese Medical Education Association, Tumor Minimally Invasive Therapy Specialized Committee, Chinese Anti-Cancer Association
… +1 more, MRI Intervention Specialized Committee, National Tumor Minimally Invasive Therapy Industrial Technology Innovation Strategic Alliance
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942319
·
Publisher ↗
MRI-guided interventional techniques integrate the high-resolution imaging capabilities of magnetic resonance imaging (MRI) with minimally invasive interventional diagnostic and therapeutic technologies. Through real-tim...MRI-guided interventional techniques integrate the high-resolution imaging capabilities of magnetic resonance imaging (MRI) with minimally invasive interventional diagnostic and therapeutic technologies. Through real-time dynamic imaging guidance, magnetic compatibility of instruments, and multiparametric functional assessment, these techniques enable precise diagnosis and targeted treatment of lesions throughout the body. Leveraging MRI' s core strengths of high soft-tissue resolution, multiparametric functional imaging, real-time monitoring, and absence of ionizing radiation, MRI-guided interventions offer unique value in complex areas such as the brain and liver dome, where traditional CT or ultrasound guidance may fall short. They are widely applied in diagnostic and therapeutic scenarios, including percutaneous biopsy and tumor ablation treatments such as radiofrequency, microwave, cryotherapy, and focused ultrasound, as well as neuromodulation. However, current clinical applications face challenges such as significant variability in equipment, lack of standardized procedures, and inadequate management of complications, leading to inconsistent therapeutic outcomes and restricted application of the technology. To address these issues, the MRI Interventional Expert Group under the Chinese College of Interventional Physicians, in collaboration with multidisciplinary experts, has developed this consensus statement. It systematically standardizes the indications and contraindications, selection criteria for equipment and instruments, requirements for operating room management, detailed procedural steps, perioperative quality control measures, and prevention and management strategies for various complications. The aim is to provide standardized guidance for clinical practice, enhance the safety and efficacy of diagnosis and treatment, and promote the standardized application of this technology.
Chinese Nutrition Society Branch of Developmental Disorders and Nutritional Therapy
Zhonghua Nei Ke Za Zhi
· 2026 Apr · PMID 41942318
·
Publisher ↗
Autism spectrum disorder (ASD) is a severe neurodevelopmental condition among children in China, with a prevalence of approximately 1.8%. In addition to core features-including deficits in language and communication, ste...Autism spectrum disorder (ASD) is a severe neurodevelopmental condition among children in China, with a prevalence of approximately 1.8%. In addition to core features-including deficits in language and communication, stereotyped behaviors, and restricted interests-many patients present with dietary imbalance, nutritional deficiencies, gastrointestinal symptoms, and gut dysbiosis. Dietary patterns influence neurodevelopment and nervous system function through the gut-brain axis. Over recent years, dietary interventions have been increasingly incorporated into comprehensive ASD management and have demonstrated benefits in alleviating gastrointestinal disturbances and specific ASD-related symptoms. However, given the high heterogeneity of ASD, treatment responses vary considerably, and no standardized or widely accepted intervention strategy has been established. Based on available scientific evidence and clinical practice, this consensus proposes a framework and provides recommendations for dietary intervention in ASD. The core recommendations include recognizing dietary intervention as a fundamental component of ASD treatment; advocating for a balanced and healthy diet while limiting high-sugar and ultra-processed foods; and implementing specific dietary approaches in combination with individualized nutritional supplementation according to coexisting multisystem symptoms. The aim of this consensus was to provide clinical guidance for healthcare professionals, promote the application of dietary interventions, and improve clinical outcomes and prognosis for individuals with ASD.
Zhonghua Nei Ke Za Zhi
· 2026 Mar · PMID 41834621
·
Publisher ↗
A retrospective analysis was conducted on nine patients with active duodenal diverticular bleeding for whom initial gastroscopic hemostasis had failed between 2016 and 2024. All patients subsequently underwent duodenosco...A retrospective analysis was conducted on nine patients with active duodenal diverticular bleeding for whom initial gastroscopic hemostasis had failed between 2016 and 2024. All patients subsequently underwent duodenoscopic hemostatic interventions. Primary outcomes were the technical success rate and complication rate. Secondary outcomes comprised the endoscopic hemostatic techniques employed, anesthesia type, changes in hemoglobin levels, and the need for salvage arterial embolization or surgery. The technical success rate for duodenoscopic hemostasis was 8/9. The hemostatic modalities applied under duodenoscopy included clip application, electrocoagulation combined with clip placement, argon plasma coagulation, hemostatic powder spray, epinephrine injection combined with clipping, and epinephrine injection combined with electrocoagulation and clip placement. Three patients underwent the procedure under intravenous general anesthesia, while six were managed under conscious sedation. One patient experienced persistent hematemesis and melena after hemostatic powder spray application, representing a treatment failure; the following day, the patient underwent successful interventional radiology-guided embolization. No procedure-related complications occurred in the successfully treated cases. Postoperative hemoglobin levels stabilized in all eight patients who achieved technically successful hemostasis. Duodenoscopic hemostasis represents a safe and effective therapeutic approach for patients with active duodenal diverticular hemorrhage for whom initial gastroscopic hemostasis has failed.
Peng SH, Yao Y, Zhang GK
… +8 more, Luan Z, Peng LH, Ren RR, Chen Y, Zhang HW, Wu JL, Wang SF, Sun G
Zhonghua Nei Ke Za Zhi
· 2026 Mar · PMID 41834620
·
Publisher ↗
Leveraging data from the UK Biobank, this study investigated the association between adverse childhood experiences (ACEs) and anxiety/depression comorbidity among patients with irritable bowel syndrome (IBS). Whether any...Leveraging data from the UK Biobank, this study investigated the association between adverse childhood experiences (ACEs) and anxiety/depression comorbidity among patients with irritable bowel syndrome (IBS). Whether any potential association was specific to the IBS population was also evaluated. This was a retrospective case-control study. The data extraction cutoff date was October 6, 2023. A total of 11 027 patients with diagnosed IBS were included as the case group for primary analysis, and 144 536 non-IBS participants from the same period were included as the control group for specificity verification. Multivariate logistic regression models were used to assess the association between ACEs and anxiety/depression, adjusting for potential confounding factors, including age, sex, adverse life events in adulthood, smoking, alcohol consumption, body mass index (BMI), socioeconomic status, and overall health. Subgroup analyses were further conducted stratified by age and sex. Finally, interaction analyses were performed to test whether the impacts of ACEs differed between the IBS and control groups. The prevalence of comorbid anxiety or depression among the 11 027 patients with IBS was 32.09%. Multivariate analysis revealed that compared with patients with no history of ACEs, those reporting two or more ACEs had a 97% increased risk of comorbidity (=1.97, 95% 1.73-2.24). Each one-point increase in the total ACE score was associated with a 22% increased risk of comorbidity (=1.22, 95% 1.15-1.29). Among specific ACE types, emotional neglect (=1.90, 95% 1.66-2.19) and emotional abuse (=1.71, 95% 1.52-1.92) showed the strongest associations with comorbid anxiety/depression. Subgroup analyses indicated that these associations remained statistically significant across sexes, as well as in participants aged both 60 years and older and younger than 60 years. Interaction analyses revealed that the risk for anxiety/depression risk associated with ACEs did not differ significantly between the IBS and control groups; each one-point increase in the total ACE score was associated with a similar increase in risk in the IBS group (=1.22, 95% 1.15-1.29) and the control group (=1.24, 95% 1.21-1.27), with no statistically significant difference in effect size. ACEs, particularly emotional trauma, are robustly associated with anxiety and depression comorbidity among patients with IBS. Although the association appears consistent between IBS patients and the general population, IBS patients with a history of emotional trauma exhibit a higher prevalence of psychological comorbidity. Thus, they represent a high-risk group that warrants clinical prioritization.
Ma LL, Li CL, Zhang YX
… +3 more, Suo BJ, Zhou LY, Song ZQ
Zhonghua Nei Ke Za Zhi
· 2026 Mar · PMID 41834619
·
Publisher ↗
To evaluate the utility of genotypic resistance testing for specific antibiotics in both treatment-naïve and rescue patients with infection, providing a basis for the rational selection of patients suitable for individu...To evaluate the utility of genotypic resistance testing for specific antibiotics in both treatment-naïve and rescue patients with infection, providing a basis for the rational selection of patients suitable for individualized therapy. This was a single-center cross-sectional study performed between January 2024 and July 2025 involving 385 patients with active infection. Participants were stratified into treatment-naïve or previously treated cohorts according to their eradication history. During endoscopy, paired biopsies were obtained from corresponding sites in the gastric antrum and body; one specimen was used for the qPCR-based detection of mutations in the 23S rRNA and gyrA genes, while the other was reserved for culture with antimicrobial susceptibility testing to determine minimum inhibitory concentrations (MICs). Resistance was interpreted according to EUCAST (v.15.0) breakpoints. Categorical variables were compared using the test or Fisher's exact test. Agreement between genotypic and phenotypic resistance was assessed using the concordance rate and the statistic. Genotypic resistance rates for clarithromycin and levofloxacin increased stepwise with previous treatment exposure. Clarithromycin genotypic resistance rates in the treatment-naïve, retreatment, and refractory groups were 50.7% (109/215), 75.7% (53/70), and 93.8% (91/97), respectively (=59.01, 0.001). For levofloxacin, the respective genotypic resistance rates were 35.3% (76/215), 58.6% (41/70), and 75.3% (73/97) (=45.26, 0.001). Meanwhile, the dual genotypic resistance rates reached 22.8% (49/215), 48.6% (34/70), and 70.1% (68/97) (=65.53, 0.001), respectively. High concordance (89%-94%) and agreement (=0.58-0.86) were observed between genotypic and phenotypic resistance. While the genotypic resistance rates of to clarithromycin and levofloxacin were relatively low in treatment-naïve patients, they were significantly elevated in rescue patients. The high agreement with phenotypic resistance suggested that PCR-based genotypic resistance testing provides a viable alternative to bacterial culture and phenotypic susceptibility testing and is suitable for patients undergoing initial treatment.
Tao JN, Wang XH, Ma ZQ
… +4 more, Gao Q, Zhan YH, Ren HJ, Wei SH
Zhonghua Nei Ke Za Zhi
· 2026 Mar · PMID 41834618
·
Publisher ↗
To analyze the trend changes and risk factors associated with infection in the Qinghai region from 2019 to 2025, thereby enriching regional epidemiological data for infection. This retrospective study included patient...To analyze the trend changes and risk factors associated with infection in the Qinghai region from 2019 to 2025, thereby enriching regional epidemiological data for infection. This retrospective study included patients who initially presented at Qinghai University Affiliated Hospital with upper gastrointestinal symptoms and underwent C urea breath testing for suspected infection. Collected data included participant demographics (name, gender, age, ethnicity, altitude of residence), medical history, and C urea breath test results. Count data were statistically described using case numbers and composition ratios. Trends in the composition ratio of positivity were plotted, while Chi-square tests and logistic regression models were used to identify influencing factors and risk factors for infection in this region. A total of 19 344 cases were included as the research subjects. The results showed that the overall composition ratio for positivity from 2019 to 2025 was 49.64% (9 602/19 344), with an increasing trend from 2019 to 2021, peaking at 55.12% (2 557/4 639) in 2021, before declining to a minimum of 42.00% (753/1 793) in 2025. This trend remained consistent across sexes. The composition ratio showed a general downward trend in populations residing in the plateau area (altitude>2 500 m) and those aged ≥18 years. Statistically significant differences in the composition ratio for positivity were noted between male (50.59%; 4 852/9 591) and female (48.70%; 4 750/9 753) populations (=6.88, =0.009). At 54.93% (2 396/4 362), the composition ratio for positivity was significantly higher in the 18-40 age group than in the other groups (=69.88, 0.001). The constituent ratios for Han, Tibetan, and Hui populations were 48.40% (7 315/15 115), 56.37% (1 346/2 388), and 51.11% (941/1 841), respectively, with statistically significant differences observed among these groups (=54.16, 0.001). Statistically significant differences (=6.19, =0.013) in composition ratios were also recorded between plateau (54.08%; 444/821) and non-plateau (49.35%; 2 157/4 371) populations. The factors influencing infection in individuals with digestive system symptoms in this region were gender, age, ethnicity, and altitude. The risk factors included altitude>2 500 m (=1.198, =0.019), male sex (=1.211, =0.001), Tibetan(=1.371, <0.001) Hui ethnicity (=1.112, =0.033), and age 18-40 years (=1.320, =0.028). The overall composition ratio for positivity (detection rate) among people with upper gastrointestinal symptoms in this region from 2019 to 2025 was 49.64% (9 602/19 344), showing an initial upward trend before declining. This suggested that health awareness and socioeconomic conditions gradually improved in this region. This study further enriches the epidemiological data on infection in the Qinghai region, and has certain clinical significance for guiding prevention strategies for infection and the screening of key populations in this area.
Committee of Tumor Ablation, the Chinese College of Interventionalists, Committee of Ablation Therapy in Oncology, Chinese Anti-Cancer Association, Expert Committee on Ablation Therapy, Chinese Society of Clinical Oncology (CSCO)
Zhonghua Nei Ke Za Zhi
· 2026 Mar · PMID 41834617
·
Publisher ↗
Ablation technology represents a fundamental approach to the management of solid tumors, with cryoablation serving as a particularly effective modality due to its established therapeutic efficacy, minimally invasive natu...Ablation technology represents a fundamental approach to the management of solid tumors, with cryoablation serving as a particularly effective modality due to its established therapeutic efficacy, minimally invasive nature, lower complication rates, and broad clinical utility. China has pioneered this field through the development of a next-generation cold and hot co-ablation system that integrates low-temperature freezing with intense thermal ablation, thereby enhancing therapeutic versatility. Its efficacy and safety profile have been rigorously validated in the context of hepatocellular carcinoma. However, compared to conventional thermal ablation techniques, such as microwave, radiofrequency, and standalone cryoablation, the factors influencing the success of combined cold and hot co-ablation therapy are significantly more complex. This complexity is further intensified when targeting liver cancers situated in anatomically challenging regions, including areas adjacent to the diaphragm, hepatic hilum, gastrointestinal tract, gallbladder, and heart. To ensure the judicious application of this advanced composite ablation technology in hepatic malignancies, a comprehensive expert consensus has been meticulously established through the collaborative efforts of experts from the Committee of Ablation Therapy in Oncology, the Chinese Anti-Cancer Association, the Expert Committee on Ablation Therapy, the Chinese Society of Clinical Oncology (CSCO), and the Committee of Tumor Ablation, the Chinese College of Interventionalists.