Quality Of Life Research[JOURNAL]
Sun
200 papers
Understanding quality of life in chronic non-cancer pain: untangling the associations between medication use, psychosocial functioning, and stigma.
Vanbavinckhove J, Van Alboom M, Baert F … +6 more , Ceuterick M, Pype P, Boussery K, Bracke P, Morlion B, Goubert L
Qual Life Res · 2026 Jun · PMID 42249982 · Publisher ↗
PURPOSE: To explore the relationships between pain medication use and quality of life in individuals with chronic non-cancer pain (CNCP), with a focus on three domains: pain severity, well-being and psychosocial function...
PURPOSE: To explore the relationships between pain medication use and quality of life in individuals with chronic non-cancer pain (CNCP), with a focus on three domains: pain severity, well-being and psychosocial functioning, and stigma experiences. METHODS: A secondary analysis was conducted using cross-sectional data from an online Belgian survey. The sample consisted of 332 participants with CNCP (M = 54 years; 82% women; 18% men). Participants were categorized into four groups: individuals taking (1) no medication, (2) non-opioids, (3) mild/weak opioids, or (4) strong opioids. Pain grades were assigned using the Graded Chronic Pain Scale. Distribution of frequencies and Spearman's correlation were calculated for pain severity, while (multivariate) analysis of variance was used for all psychosocial outcomes. RESULTS: Participants classified in higher pain grades were more likely to use stronger opioids. Significant differences emerged between medication groups in well-being and functioning, as well as stigma experiences. Specifically, individuals in the strongest opioid group reported the highest levels of pain interference, social isolation, enacted and internalized stigma, alongside the lowest levels of physical functioning and social participation. After controlling for pain severity, only differences between medication groups in pain interference and physical functioning remained significant. In contrast, pain severity showed significant main effects across all outcomes: pain interference, physical functioning, social participation, social isolation, depressive symptoms, anxiety, and overall stigma. CONCLUSION: This study emphasizes the need for a multidisciplinary treatment approach, given that both pain severity and opioid use were associated with poorer quality of life among individuals with CNCP.
Listening to patients after surgery: are ePRO alerts the missing link?
Prisciandaro E, Di Maio M, Pompili C
Qual Life Res · 2026 Jun · PMID 42249979 · Publisher ↗
Abstract loading — click title to view on PubMed.
Psychometric performance of the experimental EQ-HWB-9 and EQ-5D-5L in the general Chinese population.
Zhou T, Hu H, Fan J … +3 more , Mao Z, Zhang T, Wang P
Qual Life Res · 2026 Jun · PMID 42249192 · Publisher ↗
OBJECTIVES: This study aimed to investigate the psychometric properties of the experimental version of the EuroQol Health and Wellbeing (EQ-HWB) nine instrument (EQ-HWB-9) (2022) version and to compare its measurement pe...
OBJECTIVES: This study aimed to investigate the psychometric properties of the experimental version of the EuroQol Health and Wellbeing (EQ-HWB) nine instrument (EQ-HWB-9) (2022) version and to compare its measurement performance with that of the EQ-5D-5L in the general Chinese population. METHODS: Data were collected through a national online survey with a representative sample of the general population across different geographical regions in China (N = 1037). The survey included the EQ-HWB-9, the EQ-5D-5L, and sociodemographic information, etc. The level sum score (LSS) was analyzed as the primary outcome for comparisons between the EQ-HWB-9 and EQ-5D-5L, whereas index scores were secondary given EQ-HWB-9 used the UK pilot value set while the EQ-5D-5L used the China's. Analyses included Bland-Altman agreement, response distribution, Spearman correlations for convergent validity, and known-group validity using effect sizes and sensitivity using relative efficiency (RE). RESULTS: The Bland‒Altman plot indicated good agreement between the LSS of the instruments. The ceiling effect for the EQ-HWB-9 (6.0%) was much lower than that for the EQ-5D-5L (31.2%), and no floor effect was observed. Moderate to strong correlations were shown for most overlapping items of the EQ-HWB-9 and EQ-5D-5L. In the comparison of known-group validity, both instruments demonstrated comparable performance in distinguishing between groups in terms of sex, age, health status, and disease status. For the overall health-related known groups, the EQ-HWB-9 seems to be more sensitive than the EQ-5D-5L in identifying differences. CONCLUSION: The EQ-HWB-9 shows good psychometric performance in the general Chinese population. Compared with the EQ-5D-5L, its reduced ceiling effect and comparable known-group validity support the potential application as a complementary instrument.
Health-related quality of life in older survivors of melanoma: a SEER-MHOS study.
Shan DM, Irwin L, Allaire BT … +3 more , Mochel MC, Maher ME, Jensen RE
Qual Life Res · 2026 Jun · PMID 42247192 · Full text
PURPOSE: Melanoma, which accounts for only 1% of skin cancers, causes the majority of skin cancer-related deaths and morbidity. Health-related quality of life (HRQOL) outcomes in melanoma survivors have not been well-des...
PURPOSE: Melanoma, which accounts for only 1% of skin cancers, causes the majority of skin cancer-related deaths and morbidity. Health-related quality of life (HRQOL) outcomes in melanoma survivors have not been well-described. Given increasing melanoma survivorship in recent years, there is a need to describe and quantify HRQOL outcomes in a U.S. population-based sample of melanoma cancer survivors. This study aims to characterize HRQOL in melanoma survivors based on stage of diagnosis, demographic factors, and clinical characteristics. MATERIALS AND METHODS: This cross-sectional cohort study used data from the Surveillance, Epidemiology, and End Results Medicare Health Outcomes Survey (SEER-MHOS) to identify 2955 Medicare beneficiaries diagnosed with melanoma between 1998 and 2019. HRQOL was assessed using physical (PCS) and mental (MCS) component summary scores from the Veterans Rand (VR-12), along with CDC Healthy Days. We created matched non-cancer comparison groups using 1:1 propensity score matching based on covariates including sex, age, race, education, marital status, BMI, region, and medical comorbidities. RESULTS: Less than 10% of the study population had advanced melanoma (N = 253). Advanced melanoma survivors were more likely to be non-White (5.9 vs. 3.4%; p < 0.04) and to lack a high school diploma (11.7 vs. 7.7%; p < 0.05) compared to those with localized melanoma. They also reported lower mean PCS (38.3 vs. 41.6; p < 0.05) and MCS (51.9 vs. 54.0; p < 0.05) scores compared to localized melanoma survivors, and lower mean PCS scores compared to the matched non-cancer group (38.3 vs. 42.0; p < 0.05). Furthermore, advanced melanoma survivors reported more physically unhealthy (8.3 vs. 4.8; p < 0.05) and activity limitation days (12.5 vs. 8.4; p < 0.05) compared to the matched non-cancer group. CONCLUSION: Individuals with advanced melanoma experience poorer physical and mental health than those with localized melanoma. The difference in physical health remains significant and is clinically meaningful when comparing advanced melanoma survivors to matched non-cancer individuals. These findings underscore the value of early melanoma detection and targeted psychosocial interventions for cancer survivors.
Cosmin reporting guideline for studies on measurement properties of patient-reported outcome measures and its explanation and elaboration document: translation into Brazilian Portuguese.
de Arruda GT, Terwee CB, Driusso P … +2 more , Avila MA, Mokkink LB
Qual Life Res · 2026 Jun · PMID 42247174 · Full text
PURPOSE: The COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document have been published to guide researchers in reporting studies on measurement properties of patient-reported outcome measures (PROMs)....
PURPOSE: The COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document have been published to guide researchers in reporting studies on measurement properties of patient-reported outcome measures (PROMs). We aimed to translate the COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document to report studies on measurement properties of PROMs into Brazilian Portuguese. METHODS: We followed an adapted four-step methodology, including artificial intelligence (AI) forward-translation and back-translation, and appraisal of all written reports by the developers/committee. RESULTS: The AI produced uncommon terms, later standardized to usual Brazilian Portuguese expressions. Back-translation showed minor discrepancies without altering meaning. Expert review corrected grammar and refined terminology. CONCLUSION: The COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document have been translated into Brazilian Portuguese and can overcome language barriers and guide Brazilian-speaking researchers, clinicians, patients, and policymakers in reporting studies on measurement properties of PROMs. Both documents are available on the COSMIN website.
Measurement properties of the USER-Participation Restriction subscale and PROMIS Ability to Participate in Social roles and Activities in in- and outpatient rehabilitation populations.
Mourits BMP, Scholten EWM, de Graaf JA … +11 more , Smeets RJEM, Nachtegaal J, de Boer CE, van Nes IJW, Reneman MF, Oosterveer DM, Valk-Kleibeuker L, Agterhof EWJ, Roorda LD, Visser-Meily JMA, Post MWM
Qual Life Res · 2026 Jun · PMID 42247168 · Full text
PURPOSE: Participation is a key rehabilitation outcome. However, there is limited evidence on the measurement properties of patient-reported outcome measures (PROMs) that assess participation in rehabilitation settings....
PURPOSE: Participation is a key rehabilitation outcome. However, there is limited evidence on the measurement properties of patient-reported outcome measures (PROMs) that assess participation in rehabilitation settings. Therefore, this study evaluated the test-retest reliability and responsiveness of two widely used PROMs: the Utrecht Scale for Evaluation of Rehabilitation - Participation (USER-P) Restriction subscale and the Patient-Reported Outcomes Measurement Information System Ability to Participate in Social Roles and Activities 4-item short form (PROMIS-APS-SF) in inpatient and outpatient settings. METHODS: In this multicentre prospective cohort study, inpatients and outpatients completed PROMs at the start of rehabilitation (T0), after six months (T1), and two weeks thereafter (T2). Test-retest reliability (T1-T2) was evaluated using intraclass correlation coefficients (ICCs), Bland-Altman plots, and the smallest detectable change (SDC). Responsiveness (T0-T1) was examined using effect sizes, area under the curve (AUC), and the minimal important change (MIC) based on the Global Rating of Change scale. RESULTS: A total of 553 patients completed PROMs at T0-T1, of whom 168 also completed them at T2. Scores on both PROMs demonstrated sufficient test-retest reliability (ICC > 0.70) across both rehabilitation settings. Moderate to large effect sizes were found, except for the PROMIS-APS-SF scores in inpatients, which showed a small effect size. The USER-P Restriction scores achieved sufficient AUC values for inpatients (0.71) and outpatients (0.72). At group level, MIC values exceeded the SDC for both PROMs, but only few did at individual level. CONCLUSION: Scores on both PROMs appeared appropriate for evaluating participation outcomes at group level within rehabilitation settings, with the USER-P Restriction scores showing better responsiveness among inpatients. However, the use of these scores for evaluating individual participation goals seems limited.
Measuring quality of life in autistic children and young people: comparing the performance of common generic health related quality of life instruments.
Constable L, O'Loughlin R, Jones R … +3 more , Hiscock H, Dalziel K, Quality of Life in Kids: Key evidence to strengthen decisions in Australia (QUOKKA) project team
Qual Life Res · 2026 Jun · PMID 42247163 · Full text
PURPOSE: To assess the comparative measurement performance of commonly used paediatric health related quality of life (HRQoL) instruments in autistic children. METHODS: The sample was 510 autistic children aged 5-18 year...
PURPOSE: To assess the comparative measurement performance of commonly used paediatric health related quality of life (HRQoL) instruments in autistic children. METHODS: The sample was 510 autistic children aged 5-18 years from the Australian Paediatric Multi-Instrument Comparison study. The psychometric performance of the PedsQL, EQ-5D-Y-5L, EQ-5D-Y-3L, CHU9D and KIDSCREEN-27 instruments was compared. Psychometric attributes assessed included acceptability (ease/difficulty completing), feasibility (time to complete), test-retest reliability, floor/ ceiling effects, convergent validity and known-groups validity (measured through schooling, special health care needs (SHCN), and the strengths and difficulties questionnaire (SDQ)). Sub-group analysis by reporter type (child vs. caregiver), child age (5-12 vs. 13-18 years) and child gender (male vs. female) was conducted. RESULTS: All measures demonstrated similarly good acceptability, feasibility, and convergent validity. Only the PedsQL, EQ-5D-Y-5L and EQ-5D-Y-3L demonstrated test-retest reliability (intraclass correlation coefficient 0.56-0.60). No floor or ceiling effects were found in the total sample however, ceiling effects for the EQ-5D-Y-3L were noted in 13-18 year olds (19.1%), males (15.6%), and children who self-reported (15.0%). For known-groups validity (Cohen's d > 0.5), only the EQ-5D-Y-5L differentiated between children in mainstream and specialist schools, only the CHU9D and PedsQL differentiated between children with and without SHCNs, and all measures differentiated between children with and without behavioural difficulties as per the SDQ. CONCLUSION: The PedsQL and EQ-5D-Y-5L were the strongest performing measures in autistic children. As performance varied by reporter type, child age, and child gender, those selecting a measure should assess evidence in their intended population of use.
Interventions to improve adolescents' sense of coherence and social support on quality of life and gingivitis: a cluster-randomised clinical trial.
Vettore MV, de Figueiredo Meira G, Castilho AVSS … +5 more , Mendes RG, Ortiz FR, Sfreddo CS, Ardenghi TM, de Carvalho Sales Peres SH
Qual Life Res · 2026 Jun · PMID 42247077 · Full text
PURPOSE: to evaluate two interventions to improve sense of coherence (SOC) and social support on oral health-related quality of life (ORHQoL), health-related quality of life (HRQoL), dental biofilm and bleeding on probin...
PURPOSE: to evaluate two interventions to improve sense of coherence (SOC) and social support on oral health-related quality of life (ORHQoL), health-related quality of life (HRQoL), dental biofilm and bleeding on probing (BOP) among adolescents. METHODS: A cluster-randomised school-based clinical trial was conducted with 254 adolescents aged 15-16 years from four secondary schools in Brazil. The SOC intervention group (SOC-G) included seven 60-minute sessions aimed at developing and empowering positive attitudes, personal skills and coping strategies. The SOC plus social support intervention group (SOC/SS-G) comprised face-to-face and online meetings between participants and high school students to enhance social support, along with the SOC intervention. RESULTS: Mixed-effects models revealed significant effects of SOC-G and SOC/SS-G on SOC, social support, self-esteem, dental biofilm, BOP, OHRQoL and HRQoL at three-month follow-up. Structural equation modelling showed direct effects of interventions on dental biofilm and HRQoL. Interventions indirectly predicted ORHQoL via SOC change. Social support change mediated the effect of the interventions on BOP. CONCLUSION: The present findings suggest that interventions aiming to enhance SOC and social support can positively impact quality of life and periodontal clinical outcomes among adolescents. BRAZILIAN REGISTER OF CLINICAL TRIALS (REBEC): Identifier: RBR-3rxj6y6.
Correction: Mixed-Methods to Define Meaningful Change using Exit Interview and Clinical Trial Data in Patients with Tenosynovial Giant Cell Tumor (TGCT).
Gelhorn HL, Cutts KN, Harrow B … +9 more , Tait C, Saunders A, Fikre T, Han Y, Zeringo NA, Van De Sande M, Tap W, Gelderblom H, Bernthal N
Qual Life Res · 2026 May · PMID 42176240 · Full text
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Correction: Moving beyond global scores: the added value of clinical dimensions for assessing HRQoL in mental disorders.
Ki Y, McAleavey AA, Moger TA … +1 more , Moltu C
Qual Life Res · 2026 May · PMID 42133188 · Full text
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Health-related quality of life domains relevant to people in Europe undergoing cancer treatment: a systematic review of qualitative research.
Lizano-Barrantes C, Amat-Fernandez C, Garin O … +22 more , Pardo Y, Périz-Colón Ó, Saint-Jean PN, Rojas-Concha L, Thong M, Apolone G, Brunelli C, Caraceni A, Couespel N, Bos N, Groenvold M, Kaasa S, Ciliberto G, Lombardo C, Pietrobon R, Pravettoni G, Sirven A, Vachon H, Gilbert A, Velikova G, Ferrer M, EUonQoL Working Group
Qual Life Res · 2026 May · PMID 42132971 · Full text
PURPOSE: To identify and synthesize evidence from European qualitative studies on cancer-related quality of life outcomes, needs, experiences, preferences, and concerns of people undergoing cancer treatment in the last d...
PURPOSE: To identify and synthesize evidence from European qualitative studies on cancer-related quality of life outcomes, needs, experiences, preferences, and concerns of people undergoing cancer treatment in the last decade. METHODS: Systematic review ( https://www.crd.york.ac.uk/PROSPERO , CRD42024575065) of European studies using qualitative methodology, assessing constructs related to HRQoL, and involving adults receiving cancer treatment. The search was performed in PubMed and Scopus from January 2013 to July 2024. Titles, abstracts, and full texts screening, data extraction and risk of bias assessment were conducted independently by two researchers. The main outcomes were the themes reported in each study. The thematic analysis was performed by organizing the themes of the studies into categories. RESULTS: Out of 18,256 articles initially identified, 36 met the inclusion criteria: 21 with generic and 15 with specific objectives. Five categories encompassing 110 themes were identified from the generic studies: Psychological Function (n = 41), Clinical Management (n = 26), Symptoms and Physical Function (n = 18), Social Function (n = 16), and Life Disruption (n = 9). Eleven studies with specific objectives focused on clinical management with all their themes fitting within the categories identified in the generic studies. CONCLUSIONS: Results showed the predominance of psychological function and clinical management themes. Symptoms and physical function, social function, and life disruption maintained their importance within the classical HRQoL framework. The emergence of clinical management is consistent with the growing patient-centered care approach, suggesting the need to integrate this content into the evaluation of patients undergoing cancer treatment. LIMITATIONS: most European countries were not represented, and publication bias could hide traditional domains.
Do non-responders of a geriatric screening questionnaire face lower one-year survival compared to responders? A retrospective cohort study.
Carlson KH, Duval L, Grove BE … +7 more , Menzel CB, Snyder C, Ryg J, Schrøder JH, Aiyegbusi OL, Grytnes R, Schougaard LMV
Qual Life Res · 2026 May · PMID 42070215 · Full text
PURPOSE: A geriatric screening questionnaire was implemented in 2020 at the Department of Oncology, Gødstrup Hospital, Denmark, to identify frailty and individualize cancer care for all patients aged ≥ 60 years. However,...
PURPOSE: A geriatric screening questionnaire was implemented in 2020 at the Department of Oncology, Gødstrup Hospital, Denmark, to identify frailty and individualize cancer care for all patients aged ≥ 60 years. However, not all patients answered. The primary aim of this study was to investigate the association between response status to the geriatric screening questionnaire and one-year survival. A secondary aim was to compare one-year survival according to the responders’ frailty status. METHODS: We conducted a retrospective cohort study including all patients with cancer aged ≥ 60 who were enrolled in the geriatric screening between August 2020 and October 2023. The survival curves for responders and non-responders and across the patients’ frailty status were visualized using Kaplan–Meier plots. The associations were analyzed using logistic regression adjusted for potential confounders. RESULTS: In total, 702 patients were included. Among these, 28.1% were non-responders, 46.7% were classified as high risk of frailty, and 25.2% as low risk of frailty. The non-responders had the lowest survival, which declined rapidly in the first 100 days. Survival was similarly lower among non-responders and responders at high risk of frailty, compared to responders at low risk. When adjusted for cohabiting status, age, and cancer type, the odds ratio of survival among non-responders compared to responders was 0.63 (95%CI: 0.42;0.92). CONCLUSION: The non-responders had the lowest survival, comparable to patients at high risk of frailty among the responders. Their survival declined rapidly suggesting that non-response may signal vulnerability and warrant closer clinical attention or early supportive care.
Quality of life among women of reproductive age during the accumulation of multiple chronic conditions.
Baneshi MR, Dobson A, Mishra GD
Qual Life Res · 2026 May · PMID 42070208 · Full text
PURPOSE: We examined the temporal association between the number of chronic conditions and health-related quality of life (HRQOL) among women of reproductive age and assessed how individual conditions affected specific H...
PURPOSE: We examined the temporal association between the number of chronic conditions and health-related quality of life (HRQOL) among women of reproductive age and assessed how individual conditions affected specific HRQOL dimensions. METHODS: Data from 9323 women born between 1973 and 1978 who participated in the Australian Longitudinal Study on Women’s Health and had no chronic health condition at the baseline survey were analysed. Linear mixed-effects models examined the temporal association between the number of conditions and SF-36 HRQOL and also compared HRQOL between women with and without six conditions: musculoskeletal disorders, diabetes, asthma, endometriosis, uterine fibroids, and cancer. RESULTS: Women who remained free of conditions during ages 18 to 49 maintained stable physical component scores (PCS) and improved mental component scores (MCS). Accumulating conditions was associated with declining scores, more in PCS than MCS. The largest and smallest decline per an additional condition was observed in role physical (6.5 points; 95% CI 6.0, 7.0) and mental health (1.2 points; 0.9, 1.5). Within-group analysis found that all conditions were associated with PCS decline. Effects on MCS varied by condition and outcome. Between-group comparisons revealed that women with musculoskeletal disorders, diabetes, or asthma had lower PCS and MCS scores than women without those conditions. Endometriosis, uterine fibroids, and cancer showed smaller and more dimension-specific reductions. CONCLUSION: Women who did not develop chronic conditions maintained their PCS scores and had improvements in MCS scores. This underscores the value of preventing chronic conditions in early and mid-adulthood for maintaining physical and mental well-being.
Reliability and validation of the German WHOQOL-BREF in adults with congenital heart disease.
Schröder D, Nebel L, Le Butt TR … +5 more , Sadlonova M, Herrmann-Lingen C, Krause U, Broschmann D, Dellas C
Qual Life Res · 2026 May · PMID 42070205 · Full text
PURPOSE: Quality of Life (QoL) is a key outcome in adults with congenital heart disease (ACHD). While the WHOQOL-BREF is broadly applied, its psychometric properties have not been systematically assessed in German-speaki...
PURPOSE: Quality of Life (QoL) is a key outcome in adults with congenital heart disease (ACHD). While the WHOQOL-BREF is broadly applied, its psychometric properties have not been systematically assessed in German-speaking ACHD. This study aimed to evaluate the reliability and validity of the German WHOQOL-BREF in this population. METHODS: Descriptive statistics and item characteristics were calculated. Internal consistency was examined using Cronbach’s α and item-rest correlations. Construct validity was assessed with confirmatory factor analysis (CFA) of the original four-domain model. Known-groups validity was evaluated by comparing QoL scores across NYHA class, arrhythmia, and heart failure status. Associations between WHOQOL-BREF domains and the global items of quality of life and general health were examined using regression models. RESULTS: A total of 846 ACHD patients participated (mean age = 33.08 ± 12.0 years, 45.3% female); after excluding cases with excessive missing responses, 805 remained for analysis. Internal consistency ranged from acceptable to good (Cronbach’s α = 0.69–0.84). CFA confirmed the four-factor structure with good model fit (CFI = 0.993, RMSEA = 0.036, SRMR = 0.045). Known-groups comparisons showed lower QoL scores in patients with higher symptom burden. Regression analyses demonstrated that psychological and physical domains were the strongest factors of global QoL and health, explaining up to 47.4% and 44.8% of the variance. CONCLUSION: The German WHOQOL-BREF demonstrates good psychometric properties in ACHD and provides a robust tool for multidimensional QoL assessment, though the social domain shows limitations.
The association of food insecurity with psychological distress and health-related quality of life in the general adult population of Lebanon.
Kharroubi SA, Ballout R, Al Sayah F
Qual Life Res · 2026 May · PMID 42070201 · Publisher ↗
PURPOSE: The socio-economic situation in Lebanon has been dramatically deteriorating over the years affecting food insecurity (FI), psychological distress, and health-related quality of life (HRQoL). Therefore, the objec...
PURPOSE: The socio-economic situation in Lebanon has been dramatically deteriorating over the years affecting food insecurity (FI), psychological distress, and health-related quality of life (HRQoL). Therefore, the objectives of the study are to estimate the prevalence and severity of FI among Lebanese residents; evaluate the association between FI and psychological distress; and examine the association between FI and HRQoL. METHODS: A cross-sectional study was conducted among residents of Lebanon aged 18 years or older in 2024. The final sample included 519 participants. The Food Insecurity Experience Scale, Beirut Distress Scale (BDS), and EQ-5D-5 L were used to assess FI, distress, and HRQoL levels, respectively. The questionnaire also included sociodemographic and general health-related questions. Regression analysis was applied to explore the association of FI with psychological distress and HRQoL after adjustment for relevant covariates. RESULTS: 14.3% of the participants exhibited moderate to severe FI. A moderate level of HRQoL was shown with a mean of 74.18 (SD = 19.0) for the EQ-VAS. Moreover, FI was significantly associated with HRQoL and psychological distress. FI (B = 5.183), age (B = 0.092), gender (B = 3.998), employment status (B = 0.558), and job loss (B = 6.021), were significant predictors of the BDS (p < 0.05). Whereas FI (B = - 8.490), age (B = - 0.461), job loss (B = - 4.659), and household income (B = 1.466) were significant predictors of EQ-VAS (p < 0.05). CONCLUSION: FI was associated with poorer mental health and lower HRQoL among Lebanese residents. This highlights the impact of the socio-economic crisis and provides data that could guide efforts to improve population health, especially for NGOs that are providing support to local communities.
A pilot study of body-mind-spirit group therapy on sleep and quality of life in individuals with visual impairment.
Liu CR, Tseng MY, Sharma D … +4 more , Hsieh WD, Liu WS, Chang CS, Jou JH
Qual Life Res · 2026 May · PMID 42070200 · Full text
PURPOSE: This study evaluated the feasibility and preliminary effects of body–mind–spirit (BMS) group therapy—integrating Eastern gratitude philosophies with Western psychotherapy—on sleep and quality of life (QoL) among...
PURPOSE: This study evaluated the feasibility and preliminary effects of body–mind–spirit (BMS) group therapy—integrating Eastern gratitude philosophies with Western psychotherapy—on sleep and quality of life (QoL) among adults with visual impairment (VI). METHODS: A quasi-experimental study recruited 30 adults with VI (mean age 61.5 ± 11.4 years, range 26–78; 53.3% female). The experimental group received 10 weekly 130-min BMS sessions; the control group received usual care. QoL was assessed using the WHOQOL-BREF, and sleep was measured through accelerometry (XA-5) and self-reports. RESULTS: Compared with the comparison group, the intervention group showed significant improvements in overall QoL (p = 0.01, d = 0.58), with the most robust effect observed in physical health (d = 0.71). While objective sleep metrics remained statistically unchanged, the experimental group reported moderate improvements in sleep latency (d = −0.32; 23% reduction) and increased satisfaction. Data stability was influenced by a perceived lack of security in wearable devices. Notably, longer sleep duration correlated with better psychological well-being (p = 0.01), while lower gains among younger participants were linked to significantly shorter baseline sleep duration associated with their occupations. CONCLUSION: BMS therapy is feasible and may enhance QoL and subjective sleep through improved emotional regulation. Although “circadian hardwiring” may limit physiological reset, BMS offers a psychological buffer against sleep dissatisfaction. Future trials should integrate circadian-focused strategies and address cultural conservatism regarding sensitive QoL dimensions. TRIAL REGISTRATION: IRB of Taipei City Hospital (TCHIRB-11107010); ClinicalTrials.gov (NCT07105761); Registration date: 13 August 2025.
Severe neonatal complications and long-term health-related quality of life in very preterm and/or very low birth weight survivors: evidence from the Dutch Project on preterm and small for gestational age cohort.
Bolbocean C, van Dommelen P, van der Pal S
Qual Life Res · 2026 May · PMID 42070199 · Full text
BACKGROUND: Understanding the impact of severe neonatal complications such as Bronchopulmonary Dysplasia (BPD), Intraventricular Hemorrhage (IVH), or Necrotizing Enterocolitis (NEC) on adult health-related quality of lif...
BACKGROUND: Understanding the impact of severe neonatal complications such as Bronchopulmonary Dysplasia (BPD), Intraventricular Hemorrhage (IVH), or Necrotizing Enterocolitis (NEC) on adult health-related quality of life (HRQoL) beyond the effect of prematurity itself is significant for health economic evaluation and policy. OBJECTIVE: Analyze the independent associations of BPD, IVH, NEC and multiple birth status with preference-based HRQoL utility scores in adulthood for survivors in the Dutch Project on Preterm and Small-for-gestational-age infants (POPS) a national cohort born in 1983. METHODS: Exposures were documented neonatal BPD, severe IVH (grades 3–4), NEC, and multiple birth status. HRQoL data were available for n = 644 (19 y), n = 314 (28 y), and n = 370 (35 y). Using multivariable linear regression adjusted for confounders, we assessed the association between each exposure and HRQoL utility scores and optimal functioning. Analyses incorporated inverse probability weighting to adjust for potential attrition bias. We conducted comprehensive sensitivity analyses including best-case/worst-case imputation scenarios, comparison of IPW-weighted versus unweighted estimates, and post-hoc power calculations. RESULTS: After adjustment for confounders, severe IVH (grade 3/4) was the only neonatal complication independently associated with significant and persistent decrements in overall preference-based HRQoL, with utility score reductions at 19 years (HUI3: β = − 0.08, p = 0.05), 28 years (HUI3: β = − 0.13, p = 0.01), and 35 years (SF-6D: β = − 0.07, p = 0.04). These findings were robust to IPW adjustment for attrition (all |∆β| < 0.02) and fell within plausible bounds established by best-case/worst-case sensitivity analyses. CONCLUSION: Severe IVH was associated with significant and clinically meaningful utility decrements that persisted into the fourth decade of life.
Association between child ADHD and caregivers' mental health and health-related quality of life: results from a population-based study.
Le HND, Yee R, Dona SWA … +1 more , Silk T
Qual Life Res · 2026 May · PMID 42070196 · Full text
PURPOSE: To explore (1) the association between child attention-deficit/hyperactivity disorder (ADHD)/ADHD symptoms and their caregivers’ health-related quality of life (HRQoL)/HRQoL dimensions and their mental health, a...
PURPOSE: To explore (1) the association between child attention-deficit/hyperactivity disorder (ADHD)/ADHD symptoms and their caregivers’ health-related quality of life (HRQoL)/HRQoL dimensions and their mental health, and (2) the factors that may influence caregivers’ HRQoL. METHODS: Data were drawn from the population-based Longitudinal Study of Australian Children (LSAC) at the cross-sectional Child Health CheckPoint data collection. ADHD was parent-reported of the child’s ADHD diagnosis at 10–11 years. ADHD symptoms were measured using the Strengths and Difficulties inattention-hyperactivity subscale (e.g. score > 8). Caregivers’ HRQoL was measured using the Assessment of Quality of Life 8 Dimensions (AQoL-8D) at children aged 11–12 years. Caregivers’ mental health was measured using the Kessler 6. Multivariable linear regression analysis was used to estimate the association between children’s ADHD/ADHD symptoms and caregivers’ HRQoL and mental health. RESULTS: Child ADHD was associated with poorer caregivers’ mental health (mean difference = – 1.310, 95% CI − 2.439, − 0.181). Caregiver mental health attenuated the positive association between child ADHD and caregiver HRQoL (mean difference = 0.049, 95% CI − 0.008, 0.107). Child behavioural issues and financial hardship were associated with lower caregivers’ HRQoL, while high relationship quality or level of education was associated with better HRQoL. CONCLUSION: This study confirms the association between child ADHD and poor caregivers’ mental health, but not caregivers’ HRQoL, once caregivers’ mental health was accounted for. Child behavioural issues and financial hardship were associated with reduced caregivers’ HRQoL. Future policy or service development for families of children with ADHD may consider these factors in tandem with ADHD.
Factors associated with preoperative health-related quality of life in patients undergoing lumbar spine surgery: a multi-ethnic Asian cohort.
Li X, Chern CWJ, Teo AQA … +5 more , Tan JHJ, Vasan Thakumar A, Luo N, Hey HWD, Cheng LJ
Qual Life Res · 2026 May · PMID 42070195 · Full text
OBJECTIVE: To examine sociodemographic, clinical, and healthcare-related factors associated with preoperative health-related quality of life (HRQoL) among patients undergoing surgery for degenerative lumbar spine conditi...
OBJECTIVE: To examine sociodemographic, clinical, and healthcare-related factors associated with preoperative health-related quality of life (HRQoL) among patients undergoing surgery for degenerative lumbar spine conditions in a multi-ethnic Asian population. METHODS: This cross-sectional study used baseline data from the Spine PROM Surgery Registry, including 1194 patients scheduled for surgery within a Singapore healthcare cluster between 2017 and 2022. HRQoL was measured using the EQ-5D-3L, with utility scores crosswalked to the EQ-5D-5L index using the van Hout crosswalk. Hierarchical linear regression assessed factors associated with HRQoL across three blocks: sociodemographic, clinical, and healthcare/lifestyle. Multivariable logistic regression identified factors associated with reporting problems within each EQ-5D dimension. RESULTS: Mean age was 58.1 years (SD 16.1); 51.5% were female. Mean EQ-5D-5L index was 0.43 (SD 0.38). Pain/discomfort (93.6%) and usual activities problems (84.3%) were most commonly reported. Lower EQ-5D scores were independently associated with non-outpatient presentation (β = -0.37), non-Chinese ethnicity (e.g., Malay: β = -0.10), secondary education (β = -0.15), and accident/trauma history (β = -0.11). Dimension-level analyses showed secondary education was associated with higher odds of problems in mobility (OR = 2.72), self-care (OR = 1.87), usual activities (OR = 1.80), and anxiety/depression (OR = 1.97). Non-outpatient presentation was associated with markedly higher odds of self-care problems (OR = 2.98). CONCLUSIONS: Patients awaiting lumbar spine surgery appear to have impaired preoperative HRQoL. Although the modest explained variance limits robust risk prediction, preoperative profiles may still help inform clinical discussions and shared decision-making. Non-outpatient presentation may help identify patients who could benefit from enhanced preoperative support, although this requires prospective validation. Differences by ethnicity and education suggest opportunities for culturally tailored counselling. EQ-5D dimension profiles may indicate targets for prehabilitation and provide Singapore-based benchmark data for a lumbar spine surgery cohort for patient-centred care, service benchmarking, and health technology assessment.
WOMAC-based recovery after total knee arthroplasty in a multiethnic Asian cohort: a 5-year registry-based study of interval-specific predictors of improvement.
Teow EL, Zhang X, Tan WLB … +9 more , Kong CH, Sivasubramanian H, Li X, Tan MKL, Liau ZQG, Bansback N, Luo N, Tam WSW, Cheng LJ
Qual Life Res · 2026 May · PMID 42070194 · Full text
BACKGROUND: Patient-reported outcomes (PROs) after total knee arthroplasty (TKA) are well-documented in Western populations, but long-term recovery and its determinants in multiethnic Asian populations remain poorly unde...
BACKGROUND: Patient-reported outcomes (PROs) after total knee arthroplasty (TKA) are well-documented in Western populations, but long-term recovery and its determinants in multiethnic Asian populations remain poorly understood. We aimed to characterise 5-year WOMAC recovery after TKA and to identify patient, clinical, and surgical factors associated with the odds of improvement at each consecutive postoperative interval in a multiethnic Asian cohort. METHODS: This registry-based cohort study used prospectively collected data from a tertiary hospital in Singapore. We included 4964 consecutive cases with osteoarthritis undergoing primary TKA between December 1, 2008, and December 31, 2023. The primary outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total and subscale scores, measured at baseline and at 6 months, 1, 2, and 5 years postoperatively. RESULTS: The mean (SD) total WOMAC score improved from 38.6 (15.1) at baseline to 7.5 (9.2) at 5 years. The greatest improvement occurred within the first 6 months (mean change, 27.6 points; P value < .001). In multivariable interval-specific analyses, older age (≥ 75 years; OR 0.55, 95% CI 0.39-0.79) and the presence of one or more comorbidities (OR 0.83, 95% CI 0.71-0.96) were independently associated with lower odds of long-term improvement. Interval-specific associations with ethnicity were also observed for pain and stiffness. CONCLUSIONS: In this large, multi-ethnic Asian cohort, TKA was associated with substantial and durable WOMAC improvements, primarily within the first 6 months. Interval-specific predictors of improvement were dominated by patient-level factors, notably age, comorbidity, and ethnicity, while surgical variables showed limited association. These findings support the potential value of patient-centred risk stratification and culturally responsive perioperative care in optimising long-term outcomes.
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