The Journal Of Clinical And Aesthetic Dermatology[JOURNAL]
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200 papers
Severe Nail Psoriasis and Early Psoriatic Arthritis: Illustrative Cases Confirming That Severity of Disease Is Not Solely Dependent on the Extent of Body Surface Area.
Litchman GH, Dasilva DR, Del Rosso JQ
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239848
Nail psoriasis is a chronic inflammatory manifestation frequently associated with cutaneous psoriasis and psoriatic arthritis (PsA). Fingernails and/or toenails may be affected by psoriasis. The management of nail psoria...
Nail psoriasis is a chronic inflammatory manifestation frequently associated with cutaneous psoriasis and psoriatic arthritis (PsA). Fingernails and/or toenails may be affected by psoriasis. The management of nail psoriasis can be challenging due to marked variability in clinical presentation, its chronicity, its frequent refractory nature despite a variety of therapies, and the slow rate of nail plate growth over several months. Unfortunately, the common clinical misdiagnosis as onychomycosis often leads to delay in an accurate diagnosis of nail psoriasis as well as exposure of the patient to topical and/or oral antifungal therapies that are not effective for psoriasis. Traditional treatment options for nail psoriasis often require extended courses of therapy to achieve significant results. Both of these cases were characterized by limited or absent psoriatic skin involvement, with extensive symptomatic psoriatic fingernail dystrophy and presence of PsA. This article describes the use of bimekizumab, a dual interleukin (IL)-17A and IL-17F inhibitor, for the rapid resolution of severe psoriasis in 2 patients with extensively dystrophic fingernail psoriasis and concomitant PsA, both causing marked interference with daily physical functioning and significant psychosocial impairment. Both patients rapidly achieved marked improvement of all signs and symptoms of severe psoriasis involving all affected fingernails and joints, within at least 1 to 3 months. These results add real-world evidence that further highlights the potential for accelerated improvement with specific biologic therapies effective for plaque psoriasis, with both cases supporting the rapid onset and high magnitude of efficacy for symptomatic severe psoriasis presenting with extensive dystrophy of all fingernails and PsA.
Pipeline of Devices and Aesthetics: What Is Left?
Zhou A, Klufas T, Choi E … +1 more , Schlesinger T
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239847
Aesthetic dermatology is experiencing a continued shift toward minimally invasive procedures with the least amount of patient downtime. Herein we focus on the advancements and evolving technologies in the development for...
Aesthetic dermatology is experiencing a continued shift toward minimally invasive procedures with the least amount of patient downtime. Herein we focus on the advancements and evolving technologies in the development for neurotoxins, fillers, exosomes, microneedling, and microcoring devices that are currently available or in development. These treatment advancements offer dermatologists a broader range of tools, enabling more patients to pursue cosmetic treatments with greater comfort and individualized care.
An Analysis of Thyrotropin Levels in Patients With Nonscarring Alopecia: A Single-Center Retrospective Comparative Study.
Alomary SA, Baker NJ, Schell N … +3 more , Ogunleye T, Taylor S, Milbar H
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239846
OBJECTIVE: To compare thyrotropin (TSH) levels across nonscarring alopecia (NSA) subtypes-alopecia areata (AA), telogen effluvium (TE), and androgenetic alopecia (AGA)-in a primary analysis of all patients, a secondary a...
OBJECTIVE: To compare thyrotropin (TSH) levels across nonscarring alopecia (NSA) subtypes-alopecia areata (AA), telogen effluvium (TE), and androgenetic alopecia (AGA)-in a primary analysis of all patients, a secondary analysis of euthyroid patients stratified into low-normal (0.5-2.5 mIU/L) and high-normal (2.5-4.5 mIU/L) categories, and a tertiary analysis of patients with thyroid dysfunction. METHODS: A retrospective chart review was conducted on patients diagnosed with AA, TE, or AGA at a single academic dermatology department between August 2017 and August 2024. TSH values were drawn within 3 months of the initial visit, and patient demographics were extracted from the electronic medical record. Patients with thyroid dysfunction were excluded from the secondary analysis. TSH values within the euthyroid range were stratified into low-normal and high-normal categories. A tertiary analysis of patients with frank thyroid dysfunction was later conducted. Descriptive statistics, Kruskal-Wallis tests, and Bonferroni-corrected pairwise comparisons were performed. RESULTS: Among the 1,411 patients initially identified, most TSH values were within the euthyroid range. In a secondary analysis of 1,291 euthyroid patients, there was no significant difference in TSH distribution across NSA subtypes, including when stratified into low-normal vs high-normal categories. Among patients with thyroid dysfunction (8.5%), those with TE had the highest relative proportions of both hypothyroidism (5.0%) and hyperthyroidism (5.5%). Black or African American patients with AA and TE had lower mean TSH levels than White patients; however, this was not observed in AGA. LIMITATIONS: Limitations of this study include the retrospective design and the potential for incomplete or biased medical records. CONCLUSION: TSH levels among patients with NSA did not vary significantly based on NSA subtype. Racial differences in mean TSH were observed in AA and TE, but the clinical significance remains uncertain.
Exploring the Therapeutic Potential of Topical Honey in Atopic Dermatitis.
Park A, Almatroud L, Wan L … +1 more , Lio P
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239845
Abstract loading — click title to view on PubMed.
Plant Exosome Injection: A New Boost for Postlaser Vascular Repair.
Adel N, Jo YK, Thulesen IV
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239844
BACKGROUND: Microvascular activation is a pivotal early event in oral wound healing, particularly in laser-induced injuries where thermal effects alter endothelial behavior. CD31, a key endothelial adhesion and signaling...
BACKGROUND: Microvascular activation is a pivotal early event in oral wound healing, particularly in laser-induced injuries where thermal effects alter endothelial behavior. CD31, a key endothelial adhesion and signaling molecule, provides a reliable marker for evaluating angiogenic onset, vessel reorganization, and endothelial stability. Plant-derived nanovesicles (PDNVs) have emerged as promising biotherapeutics capable of modulating cellular communication, yet their influence on CD31-mediated vascular remodeling in laser wounds remains largely unexplored. OBJECTIVE: To investigate how 2 distinct PDNV formulations modulate CD31 expression and CD31+ microvascular density in standardized blue diode laser wounds created in rabbit tongue tissue. METHODS: Controlled 450-nm diode laser micro-incisions were produced on rabbit tongues and treated locally with either Exoline or Glow exosomes. Untreated wounds served as controls. Tissue samples were harvested at baseline, Day 3, and Day 7. Histological evaluation focused primarily on CD31 immunohistochemistry to quantify endothelial activation, vessel budding, and remodeling intensity. Additional morphologic assessments supported interpretation of vascular changes. RESULTS: Both PDNV formulations significantly increased CD31+ endothelial structures compared to controls. Exoline induced the highest early CD31 expression, accompanied by dense microvascular sprouting and pronounced endothelial clustering by Day 3. Glow produced a moderate but consistent elevation in CD31 labeling, with more gradual vessel organization. By Day 7, Exoline-treated wounds exhibited mature, well-oriented vessel networks, whereas Glow-treated tissues showed intermediate remodeling. CONCLUSION: PDNVs effectively enhance CD31-mediated angiogenic activation following laser-induced mucosal injury, with Exoline demonstrating the most robust endothelial response. These findings highlight PDNVs as promising modulators of early microvascular remodeling in oral regenerative contexts.
The Treatment of Perioral (Periorificial) Dermatitis With Topical Roflumilast 0.3% Cream: An Illustrative Case Study With Rapid Onset and Prolonged Remission.
Domingues E
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239843
Periorificial dermatitis is a common inflammatory dermatosis most often presenting in adult women around the mouth with a distinctive sparing of the vermilion border. Involvement may also cluster around the eyes and nose...
Periorificial dermatitis is a common inflammatory dermatosis most often presenting in adult women around the mouth with a distinctive sparing of the vermilion border. Involvement may also cluster around the eyes and nose. Steroid use is most commonly implicated in this condition. Treatments include topical and oral antibiotics, sulfur-based creams and cleansers, azelaic acid, and nonsteroidal anti-inflammatory agents. Roflumilast cream, 0.3%, was approved in 2022 for the treatment of chronic plaque psoriasis, including intertriginous areas. Here, we present the case of a 30-year-old female patient who presented with periorificial dermatitis, which cleared in 5 days with once daily roflumilast cream, 0.3%, without adverse events, tolerability concerns, or recurrence 11 months after treatment initiation.
Low-Dose Isotretinoin: An Option for the Treatment of Scalp and Facial Rosacea.
Lillich M, Muse M, Bermudez I … +2 more , Uddin S, Appel J
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239842
Extrafacial rosacea involving the scalp is an uncommon manifestation of acne rosacea, for which evidence-based treatment guidance is limited. With this retrospective study, we aimed to evaluate the effectiveness and tole...
Extrafacial rosacea involving the scalp is an uncommon manifestation of acne rosacea, for which evidence-based treatment guidance is limited. With this retrospective study, we aimed to evaluate the effectiveness and tolerability of low-dose isotretinoin in patients with rosacea involving both the face and scalp. We conducted an observational chart review of adult male patients treated with isotretinoin for this condition at our multisite private practice between 2012 and 2022; 21 patients met inclusion criteria. Treatment courses were short with a low dose (mean cumulative dose: 81.0 mg/kg; mean daily dose: 0.67 mg/kg/day; mean duration: 3.95 months). Complete clinical clearance of facial and scalp disease was achieved in 85.7% of patients, and treatment was well tolerated, with 95.2% of patients completing a full therapeutic course. This study suggests that low-dose, short-duration isotretinoin is a viable and effective systemic treatment option for extrafacial rosacea and may fill an important gap in the management of refractory scalp disease.
Hispanic and Latino Ethnicity and Acculturation: Influences on Skin Cancer Prevention Attitudes and Behaviors.
Andrade LF, Lalama MJ, Abdi P … +6 more , Nousari Y, Godinez G, Tordjman L, Montana D, Beliz CN, Hu S
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239841
Hispanic and Latino (H/L) populations are among the fastest-growing minority groups in the United States (US), projected to collectively reach 27.5% of the population by 2060. Despite a lower melanoma incidence compared...
Hispanic and Latino (H/L) populations are among the fastest-growing minority groups in the United States (US), projected to collectively reach 27.5% of the population by 2060. Despite a lower melanoma incidence compared to non-Hispanic White (NHW) individuals, H/L individuals face disproportionately higher disease burdens, including later-stage diagnoses and worse prognoses. While differences in sun-protective behaviors and UV exposure have been noted between H/L and NHW populations, the role of acculturation-a process by which individuals adopt the cultural norms of a dominant society-remains underexplored in dermatologic health. A cross-sectional survey study was conducted from August 2023 to August 2024 of adult patients capable of providing informed consent and fluent in English or Spanish. The survey included 32 questions covering sociodemographic data, the validated Short Acculturation Scale for Hispanics, and items adapted from prior sun protection behavior studies. A total of 257 responses were collected; 160 respondents (62%) self-identified as H/L, and 141 (55%) were born outside the United States. H/L participants were more likely than non-H/L respondents to avoid peak sun exposure hours (=0.003) and to wear hats (=0.03). Among H/L respondents, higher acculturation scores were significantly associated with increased use of sunglasses (<0.001) and daily water intake (=0.002). However, overall acculturation did not influence 83.3% of surveyed health behaviors. Socioeconomic status was a stronger predictor of sun-protective practices; H/L participants from lower socioeconomic backgrounds were less likely to perform or be aware of self-skin examinations (=0.01) and less likely to wear sunglasses (=0.08). H/L individuals were approximately 20% less likely than non-H/L participants to perform regular self-skin exams (relative risk: 0.81; 95% confidence interval: 0.62-1.05). Contrary to prior assumptions, acculturation to US culture showed limited influence on most sun-protective behaviors among H/L adults in this study. Instead, socioeconomic disparities and occupational exposure-particularly in high UV-risk industries such as agriculture and construction-may contribute more directly to increased melanoma burden in this population. These findings underscore the need for dermatologic public health strategies that consider socioeconomic and occupational risk factors alongside cultural dynamics. Future multicenter studies are recommended to further explore these relationships and to improve skin cancer prevention efforts in H/L communities.
Optimizing Surgical Tray Setup and Instrument Selection in Dermatologic Surgery.
Ceilley RI, Sureshbabu S
J Clin Aesthet Dermatol · 2026 Apr · PMID 42239840
A well-organized surgical tray and deliberate instrument selection are essential components of high-quality dermatologic surgery. Proper setup enhances workflow efficiency, minimizes errors, and supports patient safety....
A well-organized surgical tray and deliberate instrument selection are essential components of high-quality dermatologic surgery. Proper setup enhances workflow efficiency, minimizes errors, and supports patient safety. Moreover, growing attention to cost and sustainability highlights the importance of reducing instrument waste without compromising the quality of care. This article reviews best practices for tray preparation, discusses historical and modern perspectives on instrument selection, and provides practical recommendations for improving efficiency in dermatologic surgery.
Challenges of Treating Recurrent Merkel Cell Carcinoma in the Rural US: A Case Report.
Hillestad CK
J Clin Aesthet Dermatol · 2026 · PMID 42239613
An 80-year-old White male individual presented with a rapidly growing lesion on his left forearm that had been increasing in size for the past 2 months. The patient resides in a northern rural state with limited access t...
An 80-year-old White male individual presented with a rapidly growing lesion on his left forearm that had been increasing in size for the past 2 months. The patient resides in a northern rural state with limited access to dermatology care. The shave biopsy performed indicated Merkel cell carcinoma (MCC). The patient was referred to oncology and surgical oncology. The patient underwent a wide local excision, then adjuvant immunotherapy with pembrolizumab. The patient presented 2 years later with a rapidly growing lesion on the left forearm in the location of the prior surgical scar, and this was found to be recurrent MCC. Two months later, a new lesion developed approximately 7 cm from the most recent surgical incision; this was also found to be MCC. MCC is a rare form of skin cancer that is the most fatal, is more invasive than other types of skin cancer, and has a high rate of mortality. Diagnosis is confirmed by biopsy. Currently, no screening tests are in place regarding MCC or recurrent MCC. Treatment often involves wide local surgical excision and radiation therapy. Adjuvant immunotherapy and targeted therapies are promising treatment options and are continuing to evolve. Patients diagnosed with MCC in rural areas have been found to have decreased life expectancy compared to urban patients. Rural patients often encounter extraneous challenges involving travel, limited access to care, and financial hardship compared to urban patients. Treating rural patients can pose challenges to the clinician involving access to care barriers, nonadherence, patient inducement, and adhering to clinical guidelines to achieve the best outcome.
Quality of Life in Young Adults With Acne.
Ades A
J Clin Aesthet Dermatol · 2026 · PMID 42239612
BACKGROUND: Acne vulgaris is highly prevalent among young adults and is associated with psychosocial distress, yet the relationship between clinical severity and quality of life (QoL) in this population remains incomplet...
BACKGROUND: Acne vulgaris is highly prevalent among young adults and is associated with psychosocial distress, yet the relationship between clinical severity and quality of life (QoL) in this population remains incompletely understood. OBJECTIVE: To evaluate changes in acne severity and dermatology-related QoL among young adults aged 18 to 22 years and to explore whether improvement in clinical grading corresponds with changes in patient-reported outcomes. METHODS: A pre-post observational study was conducted with 16 participants. At baseline (Week 0) and after 8 weeks of treatment, acne severity was assessed using the Global Acne Grading System (GAGS), and QoL was measured with the Dermatology Life Quality Index (DLQI). Descriptive statistics summarized demographic characteristics. Paired -tests compared pre- and post-treatment scores, and correlation analysis examined the relationship between changes in GAGS and DLQI. RESULTS: Both acne severity and dermatology-related QoL significantly improved over the 8-week treatment period; however, changes in GAGS scores were not significantly correlated with changes in DLQI scores, indicating that perceived QoL improvement did not directly mirror clinical acne improvement. CONCLUSION: Among young adults with acne, meaningful improvements in both clinical severity and QoL were observed following routine treatment. The lack of correlation between these changes suggests that QoL might be influenced by factors beyond visible lesion reduction, underscoring the importance of incorporating patient-reported outcomes into acne management.
Case Series: Successful Management of Refractory Plaque Psoriasis With Combined Laser Therapy and Topical Roflumilast in 2 Patients.
Kelly T
J Clin Aesthet Dermatol · 2026 · PMID 42239611
This case series describes the treatment of 2 patients with chronic plaque psoriasis refractory to conventional topical corticosteroid therapy. Both patients declined additional topical and systemic treatments and were s...
This case series describes the treatment of 2 patients with chronic plaque psoriasis refractory to conventional topical corticosteroid therapy. Both patients declined additional topical and systemic treatments and were subsequently treated monotherapy with a 1,064nm neodymium-doped yttrium aluminium garnet laser (Aerolase Neo Elite; Aerolase, Tarrytown, New York). When pruritus returned and worsened, both subjects trialed roflumilast cream 0.3% as combination therapy alongside the ongoing laser treatments. The addition of roflumilast cream greatly improved each of their symptoms, ultimately leading to resolution of pruritus and significant improvement of plaque size and texture.
From Skincare to Skin Fitness: A Performance Framework for Dermatologic Practice.
Cohen R
J Clin Aesthet Dermatol · 2026 · PMID 42028553
Preventive medicine has become the foundation of modern healthcare, emphasizing early intervention and lifestyle modification to avert disease and promote longevity. Despite this paradigm shift, dermatology remains large...
Preventive medicine has become the foundation of modern healthcare, emphasizing early intervention and lifestyle modification to avert disease and promote longevity. Despite this paradigm shift, dermatology remains largely episodic, focused on treating visible pathology rather than conditioning the skin for resilience and disease prevention. This article introduces the concept of skin fitness, a structured, proactive model that applies the principles of physical training-progression, consistency, and recovery-to dermatologic health. By integrating evidence-based topical agents, procedures, and assessment metrics, skin fitness aims to extend "skin span," enhance patient adherence, and position dermatology within the broader preventive and performance-based healthcare framework.
Selected Abstracts from Elevate-Derm Fall Conference 2025.
J Clin Aesthet Dermatol · 2026 · PMID 42028552
Abstract loading — click title to view on PubMed.
Expanding the Topical Therapeutic Landscape for Atopic Dermatitis: A Systematic Review.
Burshtein J, Nahon S, Dasilva DR … +1 more , Litchman G
J Clin Aesthet Dermatol · 2026 Mar · PMID 42027419
BACKGROUND: Atopic dermatitis (AD) is a common chronic inflammatory disease. Despite its global prevalence, the current standard of care has remained unchanged for many years. Historically, first-line agents include topi...
BACKGROUND: Atopic dermatitis (AD) is a common chronic inflammatory disease. Despite its global prevalence, the current standard of care has remained unchanged for many years. Historically, first-line agents include topical corticosteroids (TCS) and topical calcineurin inhibitors (TCIs). However, these agents have significant limitations, including local and systemic adverse effects. In the last several years, novel topical therapeutic agents have been approved by the United States Food and Drug Administration (FDA) and more are being developed. OBJECTIVE: The present review aims to summarize these topical therapeutic advances and report their efficacy and safety relative to the existing armamentarium. METHODS: Three searches were conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Agency for Healthcare Research and Quality Methods Guide for Effectiveness and Comparative Effectiveness Reviews guidelines. These included electronic searches of FDALabel (without date restriction) and PubMed and ClinicalTrials.gov (between April 8, 2020 and April 8, 2025). RESULTS: A total of 52 nongeneric, prescription topical therapeutic agents are currently approved by the FDA for AD, the majority of which are TCS (n=11; 52.4%) and TCIs (n=4; 19.0%). There have been several agents with novel mechanisms of action (n=3; 7.6%) approved by the FDA in recent years, including Janus kinase (JAK) inhibitors, nonsteroidal aryl hydrocarbon receptor (AhR) modulators, and phosphodiesterase 4 (PDE4) inhibitors. CONCLUSION: In the last 5 years, important innovations in the therapeutic landscape of AD have emerged. Treatments include novel JAK inhibitors, AhR modulators, and PDE4 inhibitors. Adopting these therapies as part of clinical care can improve patients' therapeutic outcomes and quality of life.
The Impact of Dupilumab on Psychological Wellbeing in Moderate-to-Severe Atopic Dermatitis Patients: A Phase IV Clinical Trial.
Johnson CE, Elhage KG, Spencer RK … +6 more , Jin JQ, Yeroushalmi S, Davis MS, Hakimi M, Liao W, Bhutani T
J Clin Aesthet Dermatol · 2026 Mar · PMID 42027418
OBJECTIVE: This study aims to prospectively evaluate the emotional impact of dupliumab treatment on patients with atopic dermatitis (AD) using a validated psychometric instrument, the Psychological General Wellbeing (PGW...
OBJECTIVE: This study aims to prospectively evaluate the emotional impact of dupliumab treatment on patients with atopic dermatitis (AD) using a validated psychometric instrument, the Psychological General Wellbeing (PGWB) index. This index is widely used in nondermatologic conditions and assesses self-representations of intrapersonal affective and emotional states reflecting a sense of subjective wellbeing or distress. METHODS: This was a Phase IV, open-label clinical trial using dupilumab for the treatment of moderate-to-severe AD. The primary endpoint was the change in PGWB score at Week 16 of dupilumab treatment compared to baseline. RESULTS: A total of 24 participants completed the study. The change in average PGWB score after 16 weeks of treatment with dupilumab compared to baseline was not statistically significant (5.8±19.7; =0.15). There was significant improvement in PGWB score at Week 52 of treatment (8.5±17.4; =0.03). Mean Eczema Area and Severity Index (EASI) improvements at Weeks 16 and 52 were 60.3% and 76.8%, respectively. Regarding Investigator Global Assessment (IGA), 29.2% and 41.7% of participants achieved a score of 0 or 1 at Weeks 16 and 52, respectively. LIMITATIONS: This study did not have a control arm and was limited by small sample size. CONCLUSION: Treatment with dupilumab for 52 weeks was associated with improvement of psychological wellbeing, suggesting that intervention with this interleukin (IL) 4/IL-13 inhibitor is capable of restoring quality of life in these patients. TRIAL ADMINISTRATION: NCT03667014.
Lichenoid Drug Eruption From Cetirizine Treated With Upadacitinib and Dupilumab.
Song EJ, Chandrasekaran A
J Clin Aesthet Dermatol · 2026 Mar · PMID 42027417
Cutaneous lichenoid drug eruptions (LDE) are a group of relatively uncommon adverse drug reactions characterized by widespread erythematous to violaceous scaly papules that can be difficult to differentiate from idiopath...
Cutaneous lichenoid drug eruptions (LDE) are a group of relatively uncommon adverse drug reactions characterized by widespread erythematous to violaceous scaly papules that can be difficult to differentiate from idiopathic lichen planus. Their increasing prevalence with the use of biologics, tyrosine kinase inhibitors, and immune checkpoint inhibitors has become of particular interest in dermatology. More commonly used medications, including antibiotics, antihypertensives, and nonsteroidal anti-inflammatory drugs, have also been reported to cause LDEs. While the exact pathophysiology of LDE remains to be fully elucidated, certain medications are believed to increase the antigenicity of skin proteins, thereby triggering a T-cell-mediated response via CD8+ cytotoxic T lymphocytes that target basal keratinocytes, while increased interferon γ signaling further amplifies the inflammatory process. Herein, we report a case of LDE induced by an antihistamine (cetirizine) successfully treated with both upadacitinib and dupilumab after failure of systemic corticosteroids.
Mohs Surgeons' Postoperative Care Practices for Secondary Intention Healing: A National Survey.
Silva V, Fronek L, Blalock T … +1 more , Coughlin E
J Clin Aesthet Dermatol · 2026 Mar · PMID 42027416
OBJECTIVE: This paper seeks to characterize Mohs surgeons' postoperative wound care practices for secondary intention healing (SIH) and identify trends in the use of topical agents and perceived clinical outcomes. METHOD...
OBJECTIVE: This paper seeks to characterize Mohs surgeons' postoperative wound care practices for secondary intention healing (SIH) and identify trends in the use of topical agents and perceived clinical outcomes. METHODS: A survey was distributed to American College of Mohs Surgery (ACMS) members to assess demographics, practice settings, wound care preferences, and self-reported outcomes related to SIH. Fisher's exact and χ tests were used to evaluate associations between surgeon characteristics and wound care practices. RESULTS: Petroleum emollients were used by 96.4% of respondents. Topical antibiotics, most commonly mupirocin and gentamicin, were routinely recommended by 36.1% and were associated with higher reported infection rates (=0.034). Antiseptic solutions, particularly dilute acetic acid, were more often used by early-career surgeons (=0.016). Only 10.8% of respondents used topical timolol. Conventional nonadherent dressings were preferred by 91.6% of respondents. Most surgeons reported complete healing within 4 to 8 weeks (72.3%), 95.2% of surgeons indicated infection rates of 5% or less, and 95.2% reported good to excellent cosmetic outcomes. LIMITATIONS: Low response rate and self-reported data limited generalizability. Wound location data were not stratified. CONCLUSION: Postoperative care practices for SIH vary considerably among Mohs surgeons. Despite supporting literature, the use of advanced dressings, antiseptics, and topical timolol remains limited. These findings highlight opportunities for further research and standardization of SIH wound care.
Expanding Insurance Coverage for Wound Supplies for Patients With Hidradenitis Suppurativa.
Bui J, Ntukogu A, Bui JT … +1 more , Negbenebor NA
J Clin Aesthet Dermatol · 2026 Mar · PMID 42027415
Abstract loading — click title to view on PubMed.
A Multicenter Trial Evaluating the Safety and Efficacy of a Serum Containing Plant Adaptogens in Patients With Mild-to-Moderate, Persistent Centrofacial Erythema Associated With Rosacea.
Draelos ZD, Watchmaker J, Nelson DB
J Clin Aesthet Dermatol · 2026 Mar · PMID 42027414
BACKGROUND: Persistent facial erythema is one of the most common subtypes of rosacea, often prompting patients to seek treatment. Characterized by multiple factors including adaptive immune and vascular dysregulation, ge...
BACKGROUND: Persistent facial erythema is one of the most common subtypes of rosacea, often prompting patients to seek treatment. Characterized by multiple factors including adaptive immune and vascular dysregulation, genetics, and environmental influences, skincare measures aimed at reducing erythema and strengthening the skin barrier are fundamental to treatment. Plant adaptogens are rich phytochemicals that promote homeostasis, helping to increase resistance to stress, mitigate inflammation, support the skin barrier, and prevent premature aging. A serum containing plant adaptogens demonstrated significant improvements from baseline in global skin quality in subjects with mild-to-severe facial photodamage over 12 weeks. OBJECTIVE: We sought to evaluate the safety and efficacy of a serum containing plant adaptogens (MYS) in subjects with mild-to-moderate persistent centrofacial erythema. METHODS: A multicenter, open-label trial enrolled male or female subjects 30 to 65 years of age with mild (2) to moderate (3) persistent centrofacial erythema based on a Modified Clinical Erythema grading scale (M-CEA; 0=clear to 4=severe). A subset of subjects enrolled was taking oral or topical medications for rosacea (≥6 months) with breakthrough erythema. Subjects with >5 papules or pustules were excluded from participation. The investigators assessed erythema based on the M-CEA scale and global inflammatory lesions utilizing a 5-point grading scale (0=none to 4=severe) at baseline, 2, 4, 8, and 12 weeks. Subjects assessed erythema, dryness/flaking, itching, stinging, and burning using a 5-point grading scale (0=none to 4=severe) at baseline, 2, 4, 8, and 12 weeks. Subjects also completed self-assessment questionnaires. Digital photography and adverse events (AEs) were captured throughout the study. In addition to the study product (MYS [AM/PM]), subjects used a standardized skincare regimen that included a gentle cleanser, moisturizer, and sunscreen. RESULTS: Fifty-five subjects were enrolled and 51 subjects completed the study: 38 in the Non-Medication Treatment Group (N-MTG) and 13 in the Medication Treatment Group (MTG). Significant mean reductions in the appearance of erythema of -17%, -25%, -32%, and -33% were demonstrated from baseline at Weeks 2, 4, 8, and 12 (all <0.001), respectively, with each group demonstrating significant reductions over 12 weeks. Subject-assessed erythema demonstrated comparable results for both groups combined, with -22%, -30%, -34%, and -35% significant mean reductions occurring from baseline at Weeks 2, 4, 8, and 12 (all <0.001). Significant mean reductions also occurred in papules/pustules at Weeks 4 (-29%), 8 (-43%), and 12 (-58%) (n=34; <0.05). Subjects reported improvements in dryness/flaking, itching, stinging, and burning over the study period. After 12 weeks, subjects (94%) reported that flare-ups were not as intense and their skin looked less blotchy and looked healthier. Subjects (88%) reported feeling less self-conscious about their skin's appearance. One mild, possibly related hypersensitivity reaction on the neck was reported and resolved without sequela. No subject discontinued the study due to an AE. CONCLUSION: Twice-daily use of a serum comprised of plant adaptogens in subjects with mild-to-moderate persistent centrofacial erythema demonstrated significant reductions in the appearance of erythema from baseline as assessed by investigators and subjects over 12 weeks. Significant reductions from baseline also occurred in papules/pustules. Subjects reported decreases in skin sensitivity and healthier-looking skin.
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