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Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology[JOURNAL]
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology[JOURNAL]
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200 papers
Application value of generative artificial intelligence in the field of stomatology.
Ye Y, Zeng W, Chen J … +1 more , Liu L
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610079 · Full text
OBJECTIVES: This study aims to compare and analyze three types of generative artificial intelligence (GAI) and explore their application value and existing problems in the field of stomatology in the Chinese context. MET...
OBJECTIVES: This study aims to compare and analyze three types of generative artificial intelligence (GAI) and explore their application value and existing problems in the field of stomatology in the Chinese context. METHODS: A total of 36 questions were designed, covering all the professional areas of stomatology. The questions encompassed various aspects including medical records, professional knowledge, and translation and editing. These questions were submitted to ChatGPT4-turbo, Gemini (2024.2) and ERNIE Bot 4.0. After obtaining the answers, a blinded evaluation was conducted by three experienced oral medicine physicians using a four-point Likert scale. The value of GAI in various application scenarios was evaluated. RESULTS: Gemini scored 45, ERNIE Bot scored 38, and ChatGPT scored 33 for clinical documentation and image production. For research assistance, Gemini achieved 45, ERNIE Bot had 39, and ChatGPT scored 35. Teaching assistance capabilities were rated at 54 for ERNIE Bot, 50 for Gemini, and 48 for ChatGPT. In patient consultation and guidance, Gemini scored 78, ERNIE Bot scored 59, and ChatGPT scored 48. Overall, the total scores were 218, 190, and 164 for Gemini, ERNIE Bot, and ChatGPT, respectively. Among GAI applications, the top scoring categories were article translation and polishing (26), patient-doctor communication documentation (23), and popular science content creation (23). The lowest scoring categories were literature search and reporting (13) and image generation (12). CONCLUSIONS: In the Chinese context, the application value of GAI is the highest for Gemini, followed by ERNIE Bot and ChatGPT. GAI shows significant value in translation, patient-doctor communication, and popular science writing. However, its value in literature search, reporting, and image generation remains limited.
Application of intraoral scanning registration implant robot in dental implant surgery.
Jin N, Qiao B, Zhu L … +6 more , Meng F, Lin Q, Li L, Xing L, Zhao R, Zhang H
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610078 · Full text
OBJECTIVES: This paper aims to investigate the application of intraoral scanning and cone beam computed tomography (CBCT) registration implant robot in dental implant surgery. METHODS: The data of 40 cases with dental de...
OBJECTIVES: This paper aims to investigate the application of intraoral scanning and cone beam computed tomography (CBCT) registration implant robot in dental implant surgery. METHODS: The data of 40 cases with dental defect of robot-assisted implantation from November 2023 to May 2024 were retrospectively analyzed. Before the operation, the intraoral scan data and CBCT data of the positioning markers were automatically fused with the initial CBCT images, and the registration error was calculated. The average registration error of positioning markers was determined during the operation, and the implantation accuracy was analyzed after the operation. RESULTS: The intraoral scan data and CBCT data of 40 patients with dental defect wearing positioning markers were successfully registered with the initial CBCT image, and the registration errors were (0.157±0.026) mm and (0.154±0.033) mm, respectively. Statistical analysis showed no statistical significance between them. The registration errors of the marker was (0.037 3±0.003 6) mm. A total of 55 implants were performed, and the total deviations of the implant point and the apical point were (0.78±0.41) and (0.89±0.28) mm, respectively. The transverse deviations of the implant point and the apical point were (0.44±0.36) and (0.58±0.25) mm, respectively. The depth deviations of the implant point and the apical point were (0.51±0.32) and (0.54±0.36) mm, respectively. The deviation of the implant angle was 1.24°±0.67°. CONCLUSIONS: The fusion technology based on intraoral scanning and CBCT registration can meet the accuracy requirements of preoperative registration of oral implant robots. The technology increases the choice of registration methods before robot-assisted dental implant surgery and reduces the multiple radiation exposuresof the patient.
Prospective study on the localization of anterolateral thigh perforator vessel based on mixed reality and artificial algorithm.
Liu Y, Tang X, Wu J … +4 more , Zhou L, Wu S, Qu Y, Wu X
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610077 · Full text
OBJECTIVES: This paper aims to construct a system integrating mixed reality technology with artificial algorithm and to evaluate its effectiveness in vascular localization during anterolateral thigh perforator flap surge...
OBJECTIVES: This paper aims to construct a system integrating mixed reality technology with artificial algorithm and to evaluate its effectiveness in vascular localization during anterolateral thigh perforator flap surgery to provide new insights for clinical practice. METHODS: Twenty patients undergoing anterolateral thigh perforator flap repair were selected. After attaching positioning devices on the lower limb, CT angiography (CTA) scans were performed. The 2D data obtained were converted into a 3D model of the positioning device and vessels. Mixed reality technology was utilized to achieve 3D visualization of perforator vessels. An artificial algorithm was developed in HoloLens 2 to match the positioning device automatically with its 3D model intraoperatively to overlap the perforator vessels with their 3D models. The number of perforator vessels identified within the flap harvesting area and the actual number detected during surgery were recorded to calculate the accuracy rate of vessel identification based on CTA data reconstruction. The distance between the perforator vessel exit points located by the system and the actual exit points was measured, and the error values were calculated. The surgical time required for the system to harvest the anterolateral thigh perforator flap was documented and compared with the surgical time required by conventional methods. The clinical applicability of the system was discussed. RESULTS: The CTA data reconstruction identified 30 perforator vessels, while the actual number found during surgery was 32, resulting in an identification accuracy rate of 93.75%. The average distance between the perforator vessel exit points located by the system and the actual exit points was (1.65±0.52) mm. The average surgical time for flap harvesting with the assistance of the system was (43.45±4.6) min compared with (57.6±7.9) min required by conventional methods. All perforator flaps survived the procedure. One case of flap infection occurred seven days postoperatively, and one case of partial flap necrosis was treated with symptomatic therapy, resulting in delayed healing. CONCLUSIONS: The system constructed in this paper can achieve 3D visualization of perforator vessels through mixed reality technology and improve the accuracy of perforator vessel localization using artificial algorithms, hence demonstrating potential application in anterolateral thigh perforator flap harvesting surgeries.
Application of digital model of mixed reality dynamic tracking technique in oral and maxillofacial surgery: a basic research.
Zhao S, Li C, Zhang Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610076 · Full text
OBJECTIVES: This paper aims to explore the application value of mixed reality in oral and maxillofacial surgery and to conduct dynamic tracking using an model. METHODS: By collecting preoperative enhanced CT data of pat...
OBJECTIVES: This paper aims to explore the application value of mixed reality in oral and maxillofacial surgery and to conduct dynamic tracking using an model. METHODS: By collecting preoperative enhanced CT data of patients, rebuilding 3D digital model, combined with 3D printing technology, dynamic tracking of lesions was realized in the model, and the efficiency of different registration methods was compared. RESULTS: The 3D visualized head and neck model was obtained by combining multiple anatomical models, and dynamic tracking was completed . The average tracking time of the facial mark recognition method was T45°=3.67 frames, T90°=10.67 frames, and T total=12 seconds 28 frames (30 frames per second). The average tracking time of QR code recognition method was T45°=1.67 frames, T90°=2.33 frames, and T total=11 seconds 13 frames (30 frames per second). CONCLUSIONS: The combination of MR technology and 3D printing technology can realize the dynamic tracking of lesions , which lays a foundation for the clinical application of MR technology to implement precise, personalized surgical programs.
Construction and verification of prediction model for postoperative hypokalemia in patients with oral cancer.
Wang G, Bi X, Tang X
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610075 · Full text
OBJECTIVES: This study aimed to explore the risk factors of postoperative hypokalemia in patients with oral cancer and to provide a basis for preventing and controlling postoperative hypokalemia. METHODS: We included 366...
OBJECTIVES: This study aimed to explore the risk factors of postoperative hypokalemia in patients with oral cancer and to provide a basis for preventing and controlling postoperative hypokalemia. METHODS: We included 366 patients undergoing oral cancer surgery in the Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University from January 2022 to August 2022. Univariate and multivariate analyses were used to determine the risk factors of postoperative hypokalemia. The receiver operation characteristic (ROC) curve was used to quantify the effectiveness of the factors. A nomogram of the risk factors for postoperative hypokalemia in oral cancer patients was developed and validated. RESULTS: A total of 224 patients (61.20%) had postoperative hypokalemia, the lowest serum potassium level (3.50±0.35) mmol/L on the 4th day after surgery, and the highest incidence of hypokalemia (54.68%). Variables with <0.05 in the univariate analysis were quantified by ROC curve followed by multivariate logistic regression analysis. Results showed an independent correlation with postoperative hypokalemia as follows: preoperative serum potassium<3.87 mmol/L (=0.008), preoperative serum calcium<2.31 mmol/L (=0.033), preoperative PNI<49.16 (=0.032), postoperative drainage volume>264.25 mL (=0.002). The above variables were constructed into a postoperative hypokalemia risk nomogram and verified, and a good degree of fit was found. CONCLUSIONS: The independent risk factors for postoperative hypokalemia in patients with oral cancer were as follows: preoperative serum potassium<3.87 mmol/L, preoperative serum calcium<2.31 mmol/L, preoperative PNI<49.16, and postoperative drainage volume>264.25 mL. Clinical attention should be paid to managing the above high-risk patients. Preventive potassium supplementation should be performed as soon as possible to reduce hypokalemia occurrence.
Clinical study of the effect of the metal precrown restoration in the first deciduous molar on the composite resin filling in the second deciduous molar.
Wang C, Zhang Y
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610074 · Full text
OBJECTIVES: The effect of metal precrown restoration of distal proximal maxillofacial caries in the first deciduous molar on the composite resin filling of mesio-adjacent maxillofacial caries in the second deciduous mola...
OBJECTIVES: The effect of metal precrown restoration of distal proximal maxillofacial caries in the first deciduous molar on the composite resin filling of mesio-adjacent maxillofacial caries in the second deciduous molar was investigated. METHODS: A total of 80 children aged 4-8 who visited our clinic were selected, and 120 teeth were examined. Two consecutive deciduous molars in one jaw were considered a single case when the distal proximal maxillary surface of the first deciduous molar and the mesial proximal maxillary surface of the second deciduous molar simultaneously had caries. The teeth were randomly divided into two groups: group A (68 cases), in which the first and second molars were repaired with composite resin, and group B (52 cases), in which the first deciduous molar was repaired with metal precrown after composite resin filling and the second deciduous molar was filled with composite resin. The two groups were compared in terms of the success rate of composite resin filling in the second deciduous molar. RESULTS: At 3 months, no significant difference (>0.05) was found between groups A (92.65%) and B (96.15%). At 6 months, no significant difference (>0.05) was observed between groups A (89.71%) and B (94.23%). At 12 months, statistically significant difference (<0.05) was found between groups A (73.53%) and B (88.46%); At 24 months, statistically significant difference (<0.05) was found between groups A (66.18%) and B (86.54%). CONCLUSIONS: Compared with composite resin filling of the first deciduous molar, the metal precrown restoration of the first deciduous molar can improve the success rate of composite resin filling of the second deciduous molar.
Immediate implantation of simple taper retentive implants in chronic apical infected teeth in the posterior region: a 5-year clinical observation.
Zhang X, Wei S, Yu F … +5 more , Wu H, Cao L, Cao N, Wei H, Guo S
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610073 · Full text
OBJECTIVES: This study aims to evaluate the mid- and long-term clinical efficacies of simple taper retentive implants for immediate placement in chronic apical infected teeth in the posterior region. METHODS: A total of...
OBJECTIVES: This study aims to evaluate the mid- and long-term clinical efficacies of simple taper retentive implants for immediate placement in chronic apical infected teeth in the posterior region. METHODS: A total of 36 patients with 41 simple taper retentive implants were included in the study conducted. These patients underwent immediate implant treatment for teeth with chronic apical infection in the posterior region. The soft and hard tissues surrounding the implants were assessed and documented over a period of 5 years following the completion of crown restoration. RESULTS: During the 5 years follow-up period, one implant failed with mobility, and the implant survival rate was 97.6%. The mean marginal bone resorption was (-0.74±1.03) mm from the immediate post-implant placement to the immediate post-crown restoration, and the difference in marginal bone heights between the two time points was statistically significant (<0.05). The mean marginal bone resorption was (-0.21±0.70) mm from the immediate post-crown restoration to the 5-year post-crown restoration, and the difference in marginal bone height between the two time points was not statistically significant (>0.05). No significant difference (>0.05) was observed in bone resorption between mesial and distal, maxillary and mandibular, different tooth positions, and different implant lengths. The soft tissue surrounding the implants remained healthy at the 5 years follow-up period, one implant exhibited peri-implantitis, and no mechanical complications were observed. The overall satisfaction of patients was good. CONCLUSIONS: Immediate placement of simple taper retentive implants after thorough debridement of chronic infected alveolar socket in the posterior region can achieve good mid- and long-term clinical outcomes after 5 years of loading. The soft and hard tissues were maintained in a steady state, which expanded the indications for immediate implantation.
Assessment of the efficacy and analysis of prognostic factors of flap division for postoperative airway obstruction following posterior pharyngeal flap.
Li Y, Shi B, Li J
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610072 · Full text
OBJECTIVES: Flap division is the primary method for treating postoperative airway obstruction following pharyngeal flap surgery. However, a discussion on the treatment effectiveness and prognosis of this surgery is lacki...
OBJECTIVES: Flap division is the primary method for treating postoperative airway obstruction following pharyngeal flap surgery. However, a discussion on the treatment effectiveness and prognosis of this surgery is lacking. Therefore, this study aims to explore the effectiveness of flap division in improving airway obstruction and hyponasality after pharyngoplasty and to analyze the risk factors for postoperative complications. METHODS: A retrospective review was conducted on the data of all patients who underwent flap division following pharyngeal flap for airway obstruction at our institution. Pre- and post-operative assessments of ventilation, speech, and related factors were performed using the nasal obstruction symptom evaluation scale, speech evaluation scale, nasopharyngeal fiberscope, and lateral cephalometric radiographs. A nasopharyngeal fiberscope was utilized to observe the airway port of the patients, velopharyngeal closure, and the mobility of the lateral pharyngeal walls. Lateral cephalometric radiographs were employed to evaluate the patient's maxillomandibular relationship and adenoid dimensions. A logistic regression model incorporating univariate analysis and multivariate analyses was established to identify the prognostic factors influencing the occurrence of persistent postoperative airway obstruction and hypernasality. RESULTS: Among the 63 patients, 56 patients (88.9%) experienced a reduction in the severity of airway obstruction postoperatively but 20 patients (31.7%) still presented with moderate-to-severe airway obstruction. Age at surgery (=0.023) and adenoid hypertrophy (=0.003) were significantly associated with persistent postoperative airway obstruction. All 39 individuals exhibiting preoperative hyponasality demonstrated effective resolution after flap division, and 11 patients (17.5%) experienced mild hypernasality postoperatively. Unilateral port obstruction (=0.004) and BMI (=0.027) were identified as potential independent factors influencing the development of postoperative hypernasality. CONCLUSIONS: Flap division is an effective measure for improving postoperative airway obstruction and hyponasality following pharyngeal flap, although some patients may continue to experience persistent airway obstruction and develop hypernasality after division. Age at surgery and adenoid hypertrophy are prognostic factors for persistent airway obstruction following flap division. Unilateral/bilateral nasal airway obstruction and BMI are related factors for post-operative hypernasality.
Effect of symmetrical bone repair of nasal alar base on nasal deformity after unilateral cleft lip surgery.
Jian J, Jing B, Yang C … +2 more , Shi B, Li C
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610071 · Full text
OBJECTIVES: This study aimed to compare the impacts of undertaking symmetrical bone repair of the nasal alar base combined with nasolabial deformity repair versus nasolabial deformity repair alone on the improvement in n...
OBJECTIVES: This study aimed to compare the impacts of undertaking symmetrical bone repair of the nasal alar base combined with nasolabial deformity repair versus nasolabial deformity repair alone on the improvement in nasal deformity of patients with unilateral cleft lip and alveolar cleft. METHODS: Fifty patients presenting with unilateral cleft lip and alveolar cleft were evaluated. Among them, 20 underwent nasolabial deformity repair solely (non-bone grafting group), whereas 30 patients received bone repair in conjunction with nasolabial deformity repair (bone-repair group). Preoperative measurements and one-year follow-up results were assessed through photographic anthropometric analysis. According to the Farkas anthropometric standard, the nasal anatomic landmarks were located, and 10 nostril indicators were measured. The operative effects of two groups were compared. RESULTS: In contrast to the non-bone-grafting group, the nasal deformity of patients in the bone-repair group demonstrated significant improvement one year post-operation. The symmetry parameters of the nasal columella more closely approximated 1, the columella deviation angle more closely approached 90°, and the sub-alare inclination angle and the inclination angle of the nasal alar were smaller (<0.05). CONCLUSIONS: The accomplishment of symmetrical bone repair of the nasal alar base is conducive to enhancing nasal deformity after cleft-lip surgery in patients with unilateral cleft lip and alveolar cleft. This strategy has a positive influence on nasal symmetry, the morphology of the nasal alar, and nasal base deformity.
Role of fatty acid metabolism-related genes in periodontitis based on machine learning and bioinformatics analysis.
Chen Y, Zhao A, Yang H … +4 more , Yang X, Cheng T, Rao X, Li Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610070 · Full text
OBJECTIVES: This study aims to investigate the role of genes related to fatty acid metabolism in periodontitis through machine learning and bioinformatics methods. METHODS: Periodontitis datasets GSE10334 and GSE-16134 w...
OBJECTIVES: This study aims to investigate the role of genes related to fatty acid metabolism in periodontitis through machine learning and bioinformatics methods. METHODS: Periodontitis datasets GSE10334 and GSE-16134 were downloaded from the GEO database, and the fatty acid metabolism-related gene sets were obtained from the GeneCards database. Differentially expressed fatty acid metabolism-related genes (DEFAMRGs) in periodontitis were screened using the "limma" R package. Functional enrichment and pathway analyses were conducted. Recursive Feature Elimination, Least Absolute Shrinkage and Selection Operator, and Boruta algorithm were used to determine hub DEFAMRGs and construct diagnostic models with internal and external validation. Subtypes of periodontitis related to hub DEFAMRGs were constructed using consistency clustering analysis. CIBERSORT was used to analyze immune cell infiltration in gingival tissues and explore the correlation between hub DEFAMRGs and immune cells. RESULTS: A total of 113 periodontitis DEFAMRGs were screened out as a result. The enrichment analysis results indicate that DEFAMRGs are mainly associated with immune inflammatory responses and immune cell chemotaxis.Finally, 8 hub DEFAMRGs (BTG2, CXCL12, FABP4, CLDN10, PPBP, RGS1, LGALSL, and RIF1) were identified and a diagnostic model (AUC=0.967) was constructed, based on which periodontitis was divided into two subtypes. In addition, there is a significant correlation between hub DEFAMRGs and different immune cell populations, with mast cells and dendritic cells showing higher correlation. CONCLUSIONS: This study provides new insights and ideas for the occurrence and development mechanism of periodontitis and proposes a diagnostic model based on hub DEFAMRGs to provide new directions for diagnosis and treatment.
Effect of silencing Ras homolog family member C on proliferation, invasion, and migration of salivary adenoid cystic carcinoma.
Yu W, Zhao P, Shao Y … +6 more , Xu Y, Xu J, Xie L, Yu C, He Q, Chen Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610069 · Full text
OBJECTIVES: This study aimed to investigate the effects of silencing Ras homolog family member C (RhoC) on the proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT) of salivary adenoi...
OBJECTIVES: This study aimed to investigate the effects of silencing Ras homolog family member C (RhoC) on the proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT) of salivary adenoid cystic carcinoma (SACC) and its molecular mechanisms. METHODS: A total of 27 SACC lesions and normal salivary gland tissues that were surgically resected at Qingdao Municipal Hospital from January 1, 2019 to March 1, 2024 were selected, and the expression levels of RhoC were detected by Western blot and immunohistochemistry. Three small interfering RNA (siRNAs) were designed to target the RhoC gene sequence, transfected into SACC-LM and SACC-83 cell lines, and evaluated for transfection efficiency. The protein expression levels of RhoC, Rho-associated protein kinase-1 (ROCK1), p38 mitogen-activated protein kinase (p38MAPK), phosphorylated-p38MAPK (p-p38MAPK), twist family bHLH transcription factor 1 (TWIST1), E-cadherin, N-cadherin, and Vimentin were compared using Western blot. CCK-8 assay, flow cytometry, transwell invasion assay, and wound healing assay were conducted to assess the differences in cell proliferation, apoptosis, invasion, and migration abilities among the groups. Bioinformatics methods were also used to predict possible upstream micro RNAs (miRNAs) of RhoC and their expression levels in SACC. Moreover, dual-luciferase reporter gene experiments were performed to verify the binding sites of miR-138-5p and RhoC. RESULTS: RhoC was highly expressed in SACC (<0.05). After silencing RhoC, the test group showed a significant decrease in the expression level of ROCK1, p-p38MAPK, TWIST1, N-cadherin, and Vimentin, as well as a significant increase in the expression level of E-cadherin (<0.05). No significant difference in the expression level of p38MAPK was observed (>0.05). The cell proliferation, invasion, and migration ability decreased in the test group, whereas the apoptosis rates significantly increased (<0.05). miR-138-5p was lowly expressed in SACC, and miR-138-5p mimic can significantly downregulated the luciferase activity of 293T cells after transfection with a RhoC wild-type plasmid (<0.05). CONCLUSIONS: RhoC is highly expressed in SACC, and RhoC silencing may target the downstream ROCK1/p38MAPK/TWIST1 signaling pathway, thereby inhibiting the proliferation, invasion, migration, and EMT of SACC while promoting its apoptosis. On the contrary, miR-138-5p is lowly expressed in SACC and is a potential upstream gene of RhoC, and there may be binding sites between the two genes.
Differences in near-infrared fluorescence imaging and histological analysis of cheek mucosa in golden hamsters with different pathological states.
Xie D, Shan D, Zhang L … +3 more , Chen S, Na Y, Wang Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610068 · Full text
OBJECTIVES: To explore and analyze the feasibility of using indocyanine green (ICG) near-infrared fluorescence (NIF) imaging technology for the early diagnosis of oral potential malignant disorders and oral squamous cell...
OBJECTIVES: To explore and analyze the feasibility of using indocyanine green (ICG) near-infrared fluorescence (NIF) imaging technology for the early diagnosis of oral potential malignant disorders and oral squamous cell carcinoma. METHODS: 7,12-Dimethylbenz[a]anthracene in acetone solution was used to induce various pathological models of buccal mucosal lesions (mild/moderate dysplasia, severe dysplasia, squamous cell carcinoma) in golden hamster. ICG-NIF was conducted for the quantitative analysis of the fluorescence signal of lesion tissue, and evaluation of the diagnostic and discriminative capabilities of the ICG-NIF technology for mucosal lesions in various pathological states. Immunohistochemical staining was perform to examine the microvessel density (MVD) and microlymphatic vessel density (MLVD) of mucosa in various pathological states and explore the histological reasons underlying the differences in fluorescence signals. RESULTS: The results of ICG-NIF fluorescence quantitative analysis reveal the higher fluorescence intensity of mucosal lesions in the experimental group compared with that of the normal mucosa on the control side, with statistical differences (<0.05). Moreover, the more severe the malignancy of mucosal lesions in the experimental group, the higher the fluorescence intensity. According to histopathological analysis, the malignant progression of mucosal lesions in golden hamsters was accompanied with an increase in MVD (<0.05) and a decrease in MLVD (<0.05). CONCLUSIONS: The abnormal proliferation of mucosal lesions in golden hamsters exhibits a difference in ICG-NIF fluorescence signal compared with normal mucosal tissue. Fluorescence quantitative analysis methods can provide assistance in differentiation and show potential for clinical applications.
Hierarchical evolution of bone biomimicry and osteo-coagulo-immunomodulation induced by the size of biological hydroxyapatite.
Xu J, Zhao Y, Liu H … +2 more , Yin J, Chen Z
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610067 · Full text
Biological hydroxyapatite (BHA) is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity. The clinical application of mateiral size is based on the principle of bone...
Biological hydroxyapatite (BHA) is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity. The clinical application of mateiral size is based on the principle of bone defect area adaptation, which contributes to diversity of BHA sizes. However, different sizes correspond to different hierarchical levels of bone biomimicry. As the size changes, the bone biomimicry hierarchy evolves accordingly and influences the process of bone repair and regeneration through osteo-coagulo-immunomodulation, leading to unstable bone graft outcomes. Therefore, this paper reviews the size effect of clinical BHA, analyzes the multilevel structure of natural bone, proposes the evolution of bone biomimetic hierarchy triggered by the size of BHA, and further analyzes the size-media-ted osteo-coagulo-immunomodulation. Based on the hierarchical levels of bone and its osteo-coagulo-immunomodulation effect, we provide a new understanding of the biological principle of the size effect of biomaterials and a theoretical basis for the basic research and clinical application of different size BHA materials.
Research progress in problem-solving nickel-titanium rotary instrument in endodontics.
Cui C, Quan J, Wei X
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610066 · Full text
Root canal therapy is the primary treatment method for pulpal and periapical diseases. Various advanced endodontic instruments for mechanical preparation have been marketed. The emergence of nickel-titanium rotary instru...
Root canal therapy is the primary treatment method for pulpal and periapical diseases. Various advanced endodontic instruments for mechanical preparation have been marketed. The emergence of nickel-titanium rotary instruments has greatly improved the efficiency of root canal preparation. New demands have been put forward for nickel-titanium rotary instruments as a result of the deepening of clinicians' awareness of root canal anatomy system as well as the purpose and prognosis of root canal treatment. These clinical-oriented demands accelerate instrument reform and innovation. This work presents new marketed nickel-titanium systems and discusses the advantages and limitations of these systems and how they perform in terms of the efficiency and outcome of root canal preparation.
Design strategy of hydrogel wound dressings based on oral special environment.
Xu R, Pan Z, Zou D
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Dec · PMID 39610065 · Full text
Oral wounds caused by injuries, surgeries, diseases, and chemical irritations bring pain to the patient and increase the risk of infection. Effective wound protection and repair are crucial for improving patients' qualit...
Oral wounds caused by injuries, surgeries, diseases, and chemical irritations bring pain to the patient and increase the risk of infection. Effective wound protection and repair are crucial for improving patients' quality of life and maintaining oral health. Wound dressings provide ideal healing conditions by isolating the wound from the oral environment. However, in the highly moist, microbiologically rich environment of the oral cavity, maintaining the stability of wound dressings remains a considerable challenge. Hydrogels show promising prospects for oral applications and are gradually becoming a research hotspot for addressing the challenges of oral wound protection and repair due to their excellent biocompatibility and versatile performance. In this paper, the current design strategies of hydrogel wound dressings that overcome the unique oral environment, achieve sustained adhesion and fulfill their functions are reviewed to provide new insights for the design of ideal oral wound barrier materials.
Reamer-scraping and implant-pushing technique for transcrestal sinus floor elevation.
Peng P, Wang L, Xu M … +5 more , Zheng Z, Zhao R, Xiao K, Zhou Y, Yu K
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Oct · PMID 39304514 · Full text
Transcrestal maxillary sinus floor elevation is an effective method to solve the problem of insufficient bone height in the posterior maxillary region. However, current methods, such as osteotome sinus floor elevation, c...
Transcrestal maxillary sinus floor elevation is an effective method to solve the problem of insufficient bone height in the posterior maxillary region. However, current methods, such as osteotome sinus floor elevation, cushioned grind-out technique, Smart Drill technique, etc., require specialized surgical tool boxes. In this article, we introduce a new method of transcrestal maxillary sinus elevation that uses built-in reamers of various implant systems to scrap residual bone at the sinus floor and uses the implant to push the sinus membrane during implant placement. This technique is easy to operate and time saving and has a low rate of sinus membrane perforation. After a one-year follow-up observation of 146 people and 175 implants, the endo-sinus bone gains were 5.00 (4.70, 5.30) mm and 2.10 (1.40, 2.70) mm in the group of 3 mm≤residual bone height (RBH)<5 mm and the group of 5 mm≤RBH<8 mm, respectively, which can meet the clinical requirements of implant stability. This technique is suitable in generalizing dental implantation.
Burkitt lymphoma manifested by initial oral and maxillofacial lesions: a case report in a child patient and review of related articles.
Wu H, Zhao W, Yang X … +3 more , Li X, Zhang Y, Song A
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Oct · PMID 39304513 · Full text
Burkitt lymphoma is a highly aggressive B-cell lymphoma and the fastest proliferating human malignant tumor. If the disease is found in the early stage, the patient could have a high possibility to be cured successfully,...
Burkitt lymphoma is a highly aggressive B-cell lymphoma and the fastest proliferating human malignant tumor. If the disease is found in the early stage, the patient could have a high possibility to be cured successfully, whereas the prognosis is poor in the late stage. Burkitt lymphoma can occur in children and adults, and it is categorized as local (Africa), sporadic, and immunodeficiency associated type. Sporadic Burkitt lymphoma mainly affects children and adolescents, and the most common initial sites are abdominal organs and lymph nodes. Sporadic Burkitt lymphoma manifested by initial oral and maxillofacial lesions is relatively rare. Here, a case of pediatric sporadic Burkitt lymphoma, with oral and maxillofacial lesions as the first symptoms, was reported. The patient was treated in the Department of Periodontology, Shandong University School and Hospital of Stomatology. After timely checkup was provided, the patient was transferred to another hospital and had good results. In this article, an incidence of Burkitt lymphoma, with oral and maxillofacial lesions as the first symptom, was reviewed to provide reference for oral clinicians to achieve early diagnosis and treatment of patients with Burkitt lymphoma with oral diseases and improve the success rate of treatment.
One case of Rosai-Dorfman disease misdiagnosed as facial inflammation.
Chen Y, Ma W, Nie G … +2 more , Li M, Cui Q
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Oct · PMID 39304512 · Full text
Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis. The etiology and pathogenesis of RDD have not been fully explained, and its occurrence is even rarer in the maxillofacial region. This paper report...
Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis. The etiology and pathogenesis of RDD have not been fully explained, and its occurrence is even rarer in the maxillofacial region. This paper reported a patient who was first misdiagnosed as facial inflammation caused by oral disease and finally diagnosed as RDD. Clinical features, diagnosis, treatment, and prognosis were discussed based on the literature. This work provides reference for future diagnosis and differentiation of RDD in cheek.
Localized juvenile spongiotic gingival hyperplasia: a case report.
Yang J, Zeng X, Wu Y … +1 more , Zhao H
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Oct · PMID 39304511 · Full text
Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a kind of gingival hyperplasia with unique pathological manifestations. Its clinical manifestations are atypical, and the etiology and pathogenesis are unclea...
Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a kind of gingival hyperplasia with unique pathological manifestations. Its clinical manifestations are atypical, and the etiology and pathogenesis are unclear. No case report was reported in China. The diagnosis of this disease mainly relies on pathological testing, and recurrence may occur after treatment. The best treatment method still lacks medical evidence. This paper reports a case of LJSGH in a teenager and summarizes its clinical, pathological, and treatment through literature review. This work provides a reference for the diagnosis and treatment of this disease.
Analysis of factors affecting bone volume changes after immediate implantation in the maxillary central incisor.
Yang H, Shi R, Liu Y … +3 more , Shi Y, Zhang S, Lan J
Hua Xi Kou Qiang Yi Xue Za Zhi · 2024 Oct · PMID 39304510 · Full text
OBJECTIVES: This study aimed to evaluate the clinical outcomes of immediate implantation of single maxillary central incisor and explore factors affecting post-implant bone volume. METHODS: Clinical data and imaging reco...
OBJECTIVES: This study aimed to evaluate the clinical outcomes of immediate implantation of single maxillary central incisor and explore factors affecting post-implant bone volume. METHODS: Clinical data and imaging records from pre-surgery, the day of surgery, and 6 months post-surgery of 100 patients (100 implants) with non-salvageable maxillary central incisors who underwent immediate implantation were collected. Bone thickness at the cervical, middle, and apical regions of the implant's labial and palatal sides were measured immediately post-surgery and at 6 months, and bone volume changes were observed. A regression analysis model was used to assess predictive factors for labial and palatal bone plate thickness. RESULTS: At 6 months post-surgery, the labial bone thicknesses at the cervical, middle, and apical regions were 2.35, 2.29, and 3.28 mm, respectively, and those of the palatal side were 0.00, 2.40, and 6.05 mm, respectively. The cervical region had the highest alveolar crest collapse rates, with 32.87% on the labial side and 62.20% on the palatal side. The regression model indicated that factors influencing the thickness of bone at the cervical labial side of the implant included initial bone thickness, the implant center to adjacent tooth center angle, implant diameter, and the type of implant closure (<0.05). The initial bone thickness on the palatal side was the sole predictor for bone thickness on the palatal side (<0.05). CONCLUSIONS: Immediate implantation of single maxillary central incisors yields effective clinical results. The thickness of new bone around the implant is influenced by multiple factors. A comprehensive consideration of these factors in the planning of immediate implantation is necessary to achieve optimal therapeutic outcomes.
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