J Med Biogr
· 2025 Aug · PMID 39193791
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Jean-Nicolas Marjolin was a 19th century French anatomist and surgeon. Although not strictly speaking a pivotal figure in history of medicine, he deserves to be known for at least three reasons. He (more or less accurate...Jean-Nicolas Marjolin was a 19th century French anatomist and surgeon. Although not strictly speaking a pivotal figure in history of medicine, he deserves to be known for at least three reasons. He (more or less accurately) described a type of ulcer which is nowadays referred to as Marjolin's ulcer (1828); he had the privilege of operating on the world-famous Charles-Maurice de Talleyrand-Périgord for an anthrax (1838); and a rose has been named after him since 1860.
J Med Biogr
· 2025 May · PMID 39183568
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Daniel Webster (1782-1852) was one of the most impactful United States political figures of the early and mid-nineteenth century. He served in Congress and as the Secretary of State for three Presidents. He died in Octob...Daniel Webster (1782-1852) was one of the most impactful United States political figures of the early and mid-nineteenth century. He served in Congress and as the Secretary of State for three Presidents. He died in October of 1852 and his autopsy appeared in the medical literature. Historians have reported that his cause of death was either related to a traumatic head injury he sustained in May of 1852 or from complications of alcoholic cirrhosis. In this manuscript, we will review Webster's medical history and autopsy to determine his cause of death.
J Med Biogr
· 2025 May · PMID 39183561
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The famous French scientist, Emile Roux, was previously discovered to have been secretly married to an English woman, Rose Anna Shedlock, one of the first women medical school students in Britain and Europe. Emile and Ro...The famous French scientist, Emile Roux, was previously discovered to have been secretly married to an English woman, Rose Anna Shedlock, one of the first women medical school students in Britain and Europe. Emile and Rose most likely met while in medical school in Paris, although for very different reasons, neither graduated. It was previously suggested that Rose left medical school after only a few years, although we present new evidence that that she was still a medical student four years later when she would have been near completion. Regardless, Rose moved back to England prior to taking her qualifying exams, where we found she lived at a girl's boarding school where one of her sisters was head mistress. In the following year, Emile travelled to London where he and Rose were married in a quiet civil ceremony. Soon after the wedding, Emile returned to Paris where he began working as an assistant to Louis Pasteur. In a tragic twist of fate, Rose died a year later in Madeira, which we have now noted was within days of when Emile performed his breakthrough experiments that led to the creation of vaccines in the laboratory.
J Med Biogr
· 2025 May · PMID 39183560
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The work of the serial killers William Burke and William Hare, immigrant Ulstermen who came to Scotland in 1818, is well known. When they were finally caught, having murdered 16 people and sold their bodies for dissectio...The work of the serial killers William Burke and William Hare, immigrant Ulstermen who came to Scotland in 1818, is well known. When they were finally caught, having murdered 16 people and sold their bodies for dissection, Hare turned King's evidence and after a dramatic trial Burke was hanged in January 1829. The notoriety of the case resulted in a crowd for Burke's public execution that is generally regarded as the largest that ever assembled in Edinburgh for a hanging, being estimated at between 25,000 and 35,000 people. A contemporary journal kept by a medical student named Thomas Hume was recently acquired by The Royal College of Surgeons of Edinburgh. It contains new information regarding a contingent of immigrant Irishmen who were present at the hanging. In the lead-up to the execution, they took up a position in front of the gallows and tried to prevent any non-Irish from approaching the area immediately in front of the gallows, a futile aim given the huge, rapidly accumulating mob. On being questioned by Hume on their motives, they said it was bad enough for Burke, 'the poor devil', to be hanged, but they feared he would be mocked and denigrated by the crowd and so they were there to keep the crowd away from him as much as they could. The Irish in Scotland at that time were a marginalised and ghettoised group who saw Burke as one of their own. Therefore, they most likely saw it as their duty to at least try and protect him during, in their view, his final and most harsh mistreatment by a society that had habitually mistreated him and them.
J Med Biogr
· 2025 May · PMID 39155591
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Wu Mengchao had been engaged in basic and clinical research in hepatobiliary surgery since the 1950s and is recognised as the founder and pioneer of hepatobiliary surgery in China. In his career of over 60 years, Wu perf...Wu Mengchao had been engaged in basic and clinical research in hepatobiliary surgery since the 1950s and is recognised as the founder and pioneer of hepatobiliary surgery in China. In his career of over 60 years, Wu performed over 16,000 operations and made numerous breakthroughs in hepatobiliary surgery, liver cancer signal transduction, immunotherapy and molecular pathology research. Wu's series of achievements have driven the innovative development of basic theoretical research on the liver in China, establishing it as a long-term international leader in the field of hepatobiliary surgery. This biography elucidates Wu's outstanding contributions to the establishment and development of Chinese hepatobiliary surgery.
J Med Biogr
· 2025 Aug · PMID 39155590
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Miss Isabella "Ella" Barbour Pirrie (1857-1929) made substantial contributions to nursing through her work in Belfast and Edinburgh. Born to a notable medical family, Pirrie's inclination toward nursing was influenced by...Miss Isabella "Ella" Barbour Pirrie (1857-1929) made substantial contributions to nursing through her work in Belfast and Edinburgh. Born to a notable medical family, Pirrie's inclination toward nursing was influenced by her father's profession. She trained at the Liverpool Royal Infirmary and was mentored by Florence Nightingale, whose guidance shaped her nursing philosophy and practices. Notably, Pirrie's role in the Belfast Union Workhouse Infirmary was transformative; she championed the implementation of standardized nursing uniforms, enhancing the professional standing and recognition of nurses. Her efforts led to the establishment of a formal nursing training program in Belfast, despite facing significant resistance and challenges. In 1894, Pirrie moved to Edinburgh to become the First Matron at the Lady Grisell Baillie Memorial Hospital. Her tenure there was marked by significant advancements in nursing education, including the establishment of a community and district nursing department. By the end of her service, over 140 nurses had been trained, with many pursuing international missions. Despite her resignation in 1914 due to health issues, Pirrie continued her work as the superintendent of the Deaconess Rest Home in Edinburgh until her death in 1929. Her legacy is commemorated by a statue at Belfast City Hospital and a plaque at Greyfriars' Charteris Sanctuary, reflecting her profound impact on nursing education and the professionalization of the field.
J Med Biogr
· 2025 May · PMID 39155577
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Culture collections originated in the 19th century, but it was not until 1962 that the first international conference was held at the National Research Council in Ottawa, Canada. Microbes-like epidemics-know no borders....Culture collections originated in the 19th century, but it was not until 1962 that the first international conference was held at the National Research Council in Ottawa, Canada. Microbes-like epidemics-know no borders. Collectors were concerned with public health as well as science. For the 1962 meeting, 266 scientists came from 25 countries. They recommended a special section for collections within the International Association of Microbiological Societies. By 1970, it became the World Federation of Culture Collections, which still coordinates collections worldwide. Canadian microbiologist Stanley Morris Martin (1920-2007) who had handled local arrangements for the Ottawa meeting became the inaugural president, serving from 1970 to 1976. Originally an expert on enzymes, Martin embraced his role within the international network and championed peaceful uses of microbes and the establishment of collections in developing countries. But after his retirement, he seemed to disappear. Drawing upon scientific contributions, newspapers, and interviews, this article explores the conference, its programme, challenges, and legacy. It also tracks the long-forgotten career of Stanley Martin.
J Med Biogr
· 2025 May · PMID 39155572
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The mastery of medical sciences, pharmacy, and botany can be seen in the records of Andalusian scientists. This descriptive-analytical research introduces one of the scientists of the 10th and 11th centuries AD. Medical...The mastery of medical sciences, pharmacy, and botany can be seen in the records of Andalusian scientists. This descriptive-analytical research introduces one of the scientists of the 10th and 11th centuries AD. Medical knowledge and its affiliates are taken from the medical heritage of ancient civilizations. Andalusian scientists changed Andalusia's agricultural and economic situation by adopting new agricultural methods, especially irrigation and planting of medicinal plants. The name of Ibn Wāfid shines among Andalusian scholars. He was one of the theorists in the field of pharmacology in the Middle Ages. His practical method of treating patients is remarkable. His therapies tend to use nutritional methods more than prescribing drugs. He preferred single medications to compound ones. He insisted on curing diseases through hydrotherapy in mineral springs. While working in botany, Ibn Wāfid also specialized in medicine and pharmacy. He also benefits from the experiences of his master Zahrāwi while using the works of Galen, Aristotle, and Dioscorides. One of his honours was the establishment of several botanical gardens for the kings of the time. Ibn Wāfid's attempt at the flourishing of pharmacology, botany, and medicine can be considered a significant contribution to the visibility of these sciences in Medieval Andalusia.
J Med Biogr
· 2025 May · PMID 39150457
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Elvis Presley (1935-1977) is an iconic figure in modern pop culture. Although many of his medical conditions have been the subject of extensive speculation, less is known about his ophthalmological problems, including st...Elvis Presley (1935-1977) is an iconic figure in modern pop culture. Although many of his medical conditions have been the subject of extensive speculation, less is known about his ophthalmological problems, including steroid-induced glaucoma caused by a life-long use of steroids, both prescribed and self-administered, and secondary angle closure glaucoma most likely due to anterior uveitis. Further, he had an episode of acute angle closure glaucoma in 1971 that was treated with a subconjunctival injection of a mydriatic agent or, less likely, a paracentesis combined with an iridotomy. David Meyer, MD, was Presley's main ophthalmologist from 1971 until the latter's death in 1977.
J Med Biogr
· 2025 May · PMID 39150324
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Treatment of castration-resistant prostate cancer is and has been a challenge. In 1957, the chemist Imre Könyves came to Sweden as a refugee from Hungary and started to work at AB Leo, a pharmaceutical company in Helsing...Treatment of castration-resistant prostate cancer is and has been a challenge. In 1957, the chemist Imre Könyves came to Sweden as a refugee from Hungary and started to work at AB Leo, a pharmaceutical company in Helsingborg. In 1961, he started to synthesize compounds where the oestrogens were linked to a mustard group by a carbamate. This resulted in estramustine phosphate, which was initially tested against mammary cancer with disappointing results. He then started a cooperation with urology professor Gösta Jönsson, Head of the Department of Urology at the Lund University Hospital, to test estramustine phosphate against prostate cancer. Jönsson started clinical estramustine phosphate tests in 1966. His studies were one-armed and consecutive, with a "favourable response" in 83% of previously untreated patients. These favourable results could not be reproduced in later randomized controlled studies suggesting that estramustine phosphate as primary treatment was not better than conventional estrogenic treatment. Even if the results of Gösta Jönsson's studies could not be confirmed, the subsequent randomized studies of estramustine phosphate may hide the desired action of estramustine phosphate in a subgroup of patients. It has still not been elucidated whether estramustine phosphate has effects in this subgroup of patients with ostrogen-resistant prostate cancer.
J Med Biogr
· 2025 Aug · PMID 39150322
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The transition of the Stomatology Clinic into the Department of Maxillofacial Surgery at the Medical Academy Carl Gustav Carus in Dresden shows how healthcare evolved in East Germany after the Second World War. Founded i...The transition of the Stomatology Clinic into the Department of Maxillofacial Surgery at the Medical Academy Carl Gustav Carus in Dresden shows how healthcare evolved in East Germany after the Second World War. Founded in 1954 to tackle medical staff shortages, the department grew and specialised over time, becoming a key hub for surgical dentistry in Saxony. Through structural changes, it became a semi-autonomous unit, emphasising patient care and research. By 1983, it evolved into a full Section of Stomatology, streamlining care and training, enhancing expertise and promoting collaboration. Overall, this transformation reflects a significant shift in dental healthcare and academic leadership, shaping surgical dentistry in the region.
J Med Biogr
· 2025 May · PMID 39150309
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Although there had been many previous inklings, the field of xenobiotic metabolism (as we know it today) began with an experiment reported in the 1841 literature proclaiming that the ingestion of benzoic acid led to the...Although there had been many previous inklings, the field of xenobiotic metabolism (as we know it today) began with an experiment reported in the 1841 literature proclaiming that the ingestion of benzoic acid led to the subsequent excretion of hippuric acid in human urine. A metabolic transformation undertaken by a living organism. One worker involved in the early stages of this discovery was Wilhelm Keller, although very little information about him is readily available. Hopefully, this article will go some way to counter this dearth and also highlight Keller's pioneering contribution in the development of the fields of drug metabolism and xenobiochemistry.
J Med Biogr
· 2025 May · PMID 39140800
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Johann Alexander Vogelsang, a pioneering figure in maxillofacial surgery, played an important role in developing this field in East Germany, particularly in Dresden. Born in 1890, Vogelsang pursued dentistry against his...Johann Alexander Vogelsang, a pioneering figure in maxillofacial surgery, played an important role in developing this field in East Germany, particularly in Dresden. Born in 1890, Vogelsang pursued dentistry against his family's wishes, studying at several German universities before his education was interrupted by the First World War. His experiences treating facial injuries during the war significantly influenced his professional focus. After the war, he worked in Dresden, advancing maxillofacial surgery and overcoming significant challenges posed by the rise of National Socialism. Despite political repression, he continued his work, later contributing to the war effort in the Second World War. Postwar, Vogelsang was instrumental in rebuilding Dresden's dental medical infrastructure and establishing educational programs. His legacy endures through the institutions he helped build and the advancements he made in the field. This article chronicles his life, highlighting his contributions to dental and maxillofacial surgery and his lasting impact on medical practice and education in Dresden.
J Med Biogr
· 2025 May · PMID 39129379
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The Indian journey of assisted reproductive therapy began in Calcutta on 3 October 1978, when Dr Subhas Mukhopadhyay discovered the technique of in vitro fertilisation (IVF) only 67 days following the birth of the world'...The Indian journey of assisted reproductive therapy began in Calcutta on 3 October 1978, when Dr Subhas Mukhopadhyay discovered the technique of in vitro fertilisation (IVF) only 67 days following the birth of the world's first IVF baby, Louise Brown in the United Kingdom by Edwards and Steptoe. While Edwards won the Nobel Prize in 2010 for his groundbreaking work, Mukhopadhyay, the man behind the genesis of 'Durga', India's first IVF baby, never received any recognition. Instead, he faced severe humiliation from his peers. His colleagues and the government dismissed his claims and unable to live with dishonour and disgrace, he tragically took his life on 19 June 1981. Today his innovative techniques of cryopreservation, gonadotropin stimulation and transvaginal oocyte retrieval are used worldwide across millions of fertility clinics, helping childless couples live the dream of parenthood.
J Med Biogr
· 2025 Feb · PMID 39119635
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At first glance, Martin Heinrich Corten's biography appears to be the classic story of a German physician persecuted by the Nazis. Because of his "Jewish descent," Corten lost his position as a pathologist in Berlin and...At first glance, Martin Heinrich Corten's biography appears to be the classic story of a German physician persecuted by the Nazis. Because of his "Jewish descent," Corten lost his position as a pathologist in Berlin and later his license to practice medicine. Emigration failed. But Corten was not a typical Nazi victim. In 1933, he applied for membership in the Nazi Party, and during the last two years of the war he collaborated with the Gestapo as the Hamburg representative of the "Reich Association of Jews in Germany." Although he tried to provide basic welfare and health care for Hamburg's remaining Jewish population, he was heavily involved in the deportation of Jewish citizens to concentration and extermination camps. After the war, Corten thus came into conflict with the Jewish community and lost his position as medical director of the Jewish Hospital in Hamburg. He became a "double outcast" and was unable to re-establish himself in academia. His biography, however, is a vivid example of how the line between victim and perpetrator can be blurred.
J Med Biogr
· 2025 May · PMID 39118314
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The papers from George Blair's war service as a prisoner of the Japanese in the Second World War are unusually complete. It is a valuable record because it is representative of those young doctors who provided most of th...The papers from George Blair's war service as a prisoner of the Japanese in the Second World War are unusually complete. It is a valuable record because it is representative of those young doctors who provided most of the medical care in the camps, and also because the Taiwan camps are not well documented in the literature.
J Med Biogr
· 2025 Feb · PMID 39118312
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Catherine Chisholm BA MB ChB MD FRCP CBE (1879-1952) is celebrated as the first woman to qualify in medicine from Manchester University in 1904 and is remembered for founding the Manchester Babies Hospital in 1914 (later...Catherine Chisholm BA MB ChB MD FRCP CBE (1879-1952) is celebrated as the first woman to qualify in medicine from Manchester University in 1904 and is remembered for founding the Manchester Babies Hospital in 1914 (later renamed in 1935 as the Duchess of York Hospital for Babies). She was indefatigable in her pursuit to improve the education and status of women doctors; the first woman member and president of the British Paediatric Society; first woman president of the Manchester Medical Society and was mainly responsible for establishing the Medical Women's Federation in 1917. Her career was a complex mixture of medical and social networks that linked her work as a children's physician to the Manchester Public Health Committee, Liberal politics and feminist groups. These networks played an important role in Dr Chisholm's successful career and are at the centre of this paper.
J Med Biogr
· 2025 Feb · PMID 39091059
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Kashmir's oldest Neolithic settlement dates back to 3000 BC. It stood as the centre of Buddhism and Hinduism for centuries, till the arrival of Islam in thirteenth century. Although Muslims ruled Kashmir under different...Kashmir's oldest Neolithic settlement dates back to 3000 BC. It stood as the centre of Buddhism and Hinduism for centuries, till the arrival of Islam in thirteenth century. Although Muslims ruled Kashmir under different empires for about four centuries and ever since there has always been a significant Muslim populace in Kashmir with or without Muslim rule, yet the literature about the history of health care in Kashmir and particularly the history about Muslim contributions to healthcare is sparingly limited. This paper aims at a) historical contextualization of healthcare in Kashmir, b) finding Muslim rulers` contributions if any to the healthcare system and c) exploring places of healing 'shafa-khanas' in Kashmir. In order to achieve these objectives, the methods used were data collection through locating key historical resources, by searching local libraries and bookshops and searching online academic databases, thereafter, subjecting the collected data to thematic analysis. Three themes emerged during data analysis, which corresponds to the objectives of this paper, these are a) 'Historical context of healthcare in Kashmir', b) 'Muslim contributions to healthcare in Kashmir' and c) 'Places of healing 'Shafa-khanas' in Kashmir'. The analysis shows that healthcare during Muslim rule was integrative, progressive, robust, indigenous, specialized, and efficient/accommodative. We conclude that though 'shafa-khanas' existed in medieval Kashmir, there is however not much literature available.