Advances In Mind-body Medicine[JOURNAL]
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200 papers
Cerebro-Haemodynamic Changes in Type 2 Diabetes Mellitus Following Yoga Intervention: A Pilot Study.
Mahadevappa V, Chidanand K, Amit K … +2 more , Krishna D, Singh D
Adv Mind Body Med · 2025 Winter · PMID 40064005
INTRODUCTION: Cerebral haemodynamics is highly compromised in Type 2 Diabetes Mellitus (T2DM). T2DM reduces cerebral blood flow and increases vascular resistance as the duration of the disease increases. Yoga, a holistic...
INTRODUCTION: Cerebral haemodynamics is highly compromised in Type 2 Diabetes Mellitus (T2DM). T2DM reduces cerebral blood flow and increases vascular resistance as the duration of the disease increases. Yoga, a holistic method of healing is known to influence cerebral haemodynamics. AIM: This study aimed to evaluate the effect of an integrated approach of yoga therapy on cerebral haemodynamics in T2DM patients. STUDY METHOD: Participants who met the inclusion criteria were randomly divided into yoga and control groups. The yoga group underwent 14 days of intensive diabetes-specific yoga intervention along with their standard medications, whereas the control group continued with their standard medications alone. A Transcranial Doppler instrument was used to assess the Peak systolic velocity, mean blood flow velocity, end diastolic velocity, pulsatility index, and resistance index of the middle cerebral artery on days 1 and 14. RESULTS: 20 participants (15 male and 5 female) completed the study among which 10 participants were in the yoga group (mean age: 51.0 ± 5.6 years) and the other 10 participants in the control group (mean age: 50.6 ± 4.0 years). With 14 days of yoga intervention in T2DM, both within- and between-subjects effects on cerebral haemodynamic parameters were non-significant. However, an increasing trend in the mean blood flow velocity (P = .07) and a reduction in the resistance index (P = .89) of the middle cerebral artery in the yoga group were noted. CONCLUSION: This study suggests that yoga intervention may help improve cerebral haemodynamics in people, although the change was non-significant. This may encourage medical professionals to explore the therapeutic benefits of yoga on vascular and metabolic disorders with a larger sample size and longer duration of intervention.
Tension and Trauma Releasing Exercises for People with Multiple Sclerosis: A Randomized Controlled Trial.
Skovgaard L, Trénel P, Hanehøj K … +1 more , Lynning M
Adv Mind Body Med · 2025 Winter · PMID 40064004
CONTEXT: Some studies suggests that mind-body therapies may be helpful for people with multiple sclerosis (PwMS) for symptom management. PwMS have reported benefits from Tension and Trauma Releasing Exercises (TRE); howe...
CONTEXT: Some studies suggests that mind-body therapies may be helpful for people with multiple sclerosis (PwMS) for symptom management. PwMS have reported benefits from Tension and Trauma Releasing Exercises (TRE); however, only limited research exists on the potential benefits of TRE. OBJECTIVE: The study intended to determine whether an eight-week intervention of Tension and Trauma Releasing Exercises (TRE), a mind-body therapy, could primarily reduce fatigue and secondarily decrease other MS-related symptoms and to explore new, experimental outcome measures-sleep, hand motor function, gait function, cognitive function, or mood-for use in future research on TRE for PwMS. DESIGN: The research team performed a randomized controlled trial (RCT). SETTING: The study took place at the Danish MS Society in Valby, Denmark. PARTICIPANTS: Participants were 28 members of the society who had an MS diagnosis and lived in the Copenhagen area. INTERVENTION: The research team performed simple randomization to allocate participants to the intervention and control groups. The intervention group received eight sessions of TRE and performed TRE daily at home, while the control group continued their usual care only. OUTCOME MEASURES: The primary outcome measure was self-reported fatigue measured via the Modified Fatigue Impact Scale (MFIS) at baseline and postintervention. Daily self-reported levels of nine MS-related symptoms as well as stress levels were obtained as secondary endpoints, using a digital tool, the MS PRO. For explorative purposes, daily measures of sleep duration and quality were obtained, via the Fitbit Charge 3 activity tracker. Finally, smartphone-based measurements of hand motor function, gait, cognition, and mood were obtained via the Floodlight Open (FLO) app. RESULTS: On primary outcomes, no significant differences between the TRE intervention group and the control group were detected at follow-up in the unadjusted analyses. However, when adjusted for imbalance in covariates, significant group differences were obtained in the MFIS total score (P = .03) as well as marginal significance in the MFISphys score (P = .06). The TRE intervention significantly reduced reported levels of spasticity and pain across the whole intervention period, and it showed a significant effect of gradual improvement in the 5 U-turn test over the study period. CONCLUSIONS: Positive effects on both primary and secondary outcomes from the TRE intervention were seen when adjusting for covariate imbalance. Therefore, it cannot be ruled out that TRE significantly improves fatigue in people with MS. Furthermore, the current study underlines the potential effect of bias-adjustment, when covariate imbalance is present. However, further research is needed to confirm the positive effects.
Effect of Vakrasana on Blood Glucose Levels in Type 2 Diabetes Mellitus: A Randomized Controlled Study.
Tamilselvi G, Mooventhan A, Iswarya S … +2 more , Nivethitha L, Venkateshwaran ST
Adv Mind Body Med · 2024 Fall · PMID 39447125
BACKGROUND: Diabetes mellitus is one of the most prevalent metabolic diseases. Literature suggests that yoga including a group of asanas reduces blood glucose and glycated hemoglobin levels in type 2 diabetes mellitus (T...
BACKGROUND: Diabetes mellitus is one of the most prevalent metabolic diseases. Literature suggests that yoga including a group of asanas reduces blood glucose and glycated hemoglobin levels in type 2 diabetes mellitus (T2DM). However, to the best of our knowledge, no known study evaluated the effects of a single asana (i.e., Vakrasana) in T2DM. OBJECTIVE: This study aimed to determine the effect of Vakrasanana on blood glucose levels in T2DM patients. MATERIALS AND METHODS: Sixty T2DM patients aged 51.12 ± 6.43 years were randomly (1:1 ratio) allocated to yoga group (YG) and control group (CG). YG was asked to perform only one session of Vakrasana, while the CG was on rest in a sitting posture for 10 minutes. Random blood glucose (RBG) levels were assessed before and after the intervention. RESULTS: Within-group analysis showed a significant reduction in RBG levels in YG (P < .001; Effect size (d) = 0.203), while a significant increase in RBG was observed in CG (P < .001; Effect size (d) = 0.077), compared to the respective pre-test assessments. Whereas the between-groups analysis did not show a significant difference in RBG levels between the two groups (z = 1.597; P = 0.110). However, YG had a small effect size (Effect size (d) = 0.288) in reducing RBG levels compared to CG. CONCLUSION: Ten minutes of Vakrasana has some positive effect in reducing blood glucose levels, unlike rest in sitting posture in patients with T2DM. However, further studies are required to validate the findings of this study.
Comprehensive In-Patient Neuro-rehabilitation: Harnessing Yoga's Potential - A Pilot Study in Germany.
Ashwini BC, Nagarathna R, Garner C … +2 more , Bilagi A, Palukuru S
Adv Mind Body Med · 2024 Fall · PMID 39447129
BACKGROUND: Neurological diseases require rehabilitation due to the disabling effects they induce, yet cost and therapist availability make long-term therapy difficult. However, innovative, cost-effective strategies that...
BACKGROUND: Neurological diseases require rehabilitation due to the disabling effects they induce, yet cost and therapist availability make long-term therapy difficult. However, innovative, cost-effective strategies that cater to patients' physical and mental requirements are vital to address this gap in care. Incorporating Yoga into in-patient neuro-rehabilitation holds promise as a complementary approach to enhance physical and mental recovery for individuals in a German neurological rehabilitation hospital. This study explores the potential benefits of integrating Yoga within the multimodal care framework, shedding light on its role in improving patient outcomes and overall well-being. OBJECTIVES: To study the effect of integrated yoga therapy and multimodal rehabilitation techniques in the neuro-rehabilitation of Multiple Sclerosis, Stroke, and others in an in-patient setting. DESIGN AND SETTING: A single group pre-post study was conducted at a neurological rehabilitation centre- KWA-Klinik, Stift Rottal, Bad Griesbach, Germany. Twenty patients (11 female and nine male, age 54.4 ± 9.50 years) with different neurological diseases (12-Multiple Sclerosis, 3-Stroke, 5- others) volunteered to participate in the study. INTERVENTION: The integrated yoga intervention was designed by experts from Yoga and neurology to suit neuro-rehabilitation patients. Yoga intervention included Breathing practices, yogic loosening practices, Rapid breathing (Kapalabhati), Alternate nostril breathing (Nadishuddi Pranayama), Physical postures (Asanas), and Relaxation techniques. Participants underwent yoga training for one hour daily, five days a week, for three weeks, along with other conventional rehabilitation procedures. OUTCOME MEASURES: The Pain Analog Scale and Spasticity Analog Scale were used to determine the extent of the problem. Barthel Index, Timed up and go Test, and Hand Grip Strength were used to determine the baseline functioning of a patient. Hospital Anxiety and Depression Scale (HADS) to assess anxiety and depression symptoms in patients.WHOQOL-BREF questionnaire used to assess QoL. RESULTS: There was a significant reduction in pain (66.97%, P = .001), spasticity (64.47%, P = .001), and anxiety scores (29.05%, P = .02). There is no significant decrease in depression scores (21.86%, P = .065). Improvement in Barthel index (10.38%, P < .001), timed up and go Test (11.63%, P = .001), and physical (4.92%, P = .031), psychological (4.79%, P = .036) and environmental domains (9.12%, P = .001) of WHOQOL-BREF. The results indicate that yoga therapy can effectively address common and debilitating symptoms associated with neurological disorders. Along with the improvement in daily living activities, mobility, and overall quality of life for patients with neurological conditions. CONCLUSION: Incorporating Yoga into the neuro-rehabilitation regimen for in-patients at a German neurological rehabilitation hospital has proven both achievable and advantageous. The seamless inclusion of yoga sessions within the structured rehabilitation schedules demonstrates the practicality of this integration. Future studies should focus on exploring the long-term effects of Yoga in comparison with other complementary therapies in neuro-rehabilitation.
Integrated Yoga and Naturopathy Intervention on Glycemic Profile and Autonomic Variables in Co-Existence of Diabetes Mellitus with Hypertension: A Two-Arm Observational Study.
Mohan SL, Sujatha KJ, Shetty P … +1 more , Nanjeshgowda HL
Adv Mind Body Med · 2024 Fall · PMID 39447128
BACKGROUND: Diabetes Mellitus coexisting with hypertension has received significant global attention and remains a public health challenge in the past two decades. The states of hyperinsulinemia and insulin resistance ha...
BACKGROUND: Diabetes Mellitus coexisting with hypertension has received significant global attention and remains a public health challenge in the past two decades. The states of hyperinsulinemia and insulin resistance have been postulated as causes or consequences of hypertension. Evidence shows that alternative systems of medicine can play a significant role in achieving glycemic control. This study aimed to compare and evaluate the impact of yoga and naturopathy-based lifestyles on patients with diabetes mellitus and diabetes mellitus with hypertension. METHODS: Sixty subjects were recruited into two groups, group 1 (diabetes mellitus with hypertension) and group 2 (diabetes mellitus) based on the inclusion and exclusion criteria. Both the groups underwent naturopathy and yoga intervention for ten days. The glycemic profile and heart rate variability (HRV) of the patients were assessed at the baseline and 10 days after the intervention. RESULTS: Study resulted in a significant change in both time domain and frequency domain variables (HRV, FBS, and PPBS) in both group 1 and group 2 (P < .05, for all) but the mean difference was more in group 2 with a significant difference between the two groups, P < .05. The diastolic blood pressure significantly decreased only in group 2, whereas the systolic blood pressure decreased in both groups without any difference between the two groups. CONCLUSION: The results of the present study show that integrated yoga and naturopathy management significantly help in glycemic control and autonomic functions in both groups.
Therapeutic Applications of Neem (Azadirachta indica): A Narrative Review.
Mehnaz S, Shamsi Y, Akhtar MW … +2 more , Mohanty S, Ahmad S
Adv Mind Body Med · 2024 Fall · PMID 39447127
It is no surprise that nature has provided us with many therapeutic compounds for thousands of years. Throughout history, plants and their derivatives have been used orally and locally to treat most of the diseases. In a...
It is no surprise that nature has provided us with many therapeutic compounds for thousands of years. Throughout history, plants and their derivatives have been used orally and locally to treat most of the diseases. In addition to providing a wealth of health benefits, Azadirachta indica stands out among all of them as one of the most universal and prolific trees. Since antiquity, this medicinal plant has been used in the Unani System of Medicine as well as in other traditional systems of medicine (Ayurveda, Homeopathic, Chinese, and European "Materia Medica") to treat a wide range of diseases. Almost every part of the tree can be used as medicine, including its leaves, flowers, seeds, fruits, roots, and bark, both locally and systemically after being properly processed in pharmaceutical industries. Apart from treating various skin ailments like dermatitis, eczema, acne, and fungal and bacterial infections, it also exhibits anti-malarial, anticancer, antifertility, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, neuroprotective, and wound healing properties. In modern times, it is also used in cosmetics, toiletries, and pharmaceutical products. The purpose of this review is to gather all the information available about Azadirachta indica, including its distribution, botanical description, commercial use, and medicinal properties.
Effective Management of Type-2 Diabetes Mellitus with Unani Medications: A Case Report.
Nasir F, Itrat M, Shahabuddin F … +1 more , Nikhat S
Adv Mind Body Med · 2024 Fall · PMID 39447126
INTRODUCTION: Diabetes mellitus (DM) presents a formidable global health challenge, with conventional treatments often accompanied by limitations and adverse effects. Moreover, accessibility and affordability of conventi...
INTRODUCTION: Diabetes mellitus (DM) presents a formidable global health challenge, with conventional treatments often accompanied by limitations and adverse effects. Moreover, accessibility and affordability of conventional treatments remain barriers for many individuals, particularly in low-resource settings. Hence, there is a compelling need to explore alternative therapeutic modalities, such as Unani medicine, which offer the potential for effective management of type 2 diabetes mellitus (T2DM) while potentially mitigating these drawbacks. CASE PRESENTATION: A 35-year-old female patient presented with symptoms including fatigue, increased thirst, frequent urination, and a burning sensation in both feet. Her medical history revealed Type 2 Diabetes Mellitus (T2DM), with fasting blood glucose (FBS) levels at 276 mg/dl, postprandial blood glucose levels (PPBS) at 380 mg/dl, and a glycated haemoglobin percentage (HbA1c) of 11.2%. Initially prescribed with a combination of glimepiride (1mg) and metformin (500mg) twice daily, she discontinued the treatment due to discomfort. The patient was diagnosed with Dhayābῑtus Shakari and subsequently treated with Unani medications including Qurs Ziabetus (tablets), Zulal Ziabetus (decant), Safoof Darchini (powder), and Arq Zeera (distillate), commonly used in Unani Medicine for T2DM. Additionally, she received dietary recommendations and was advised to engage in a daily 30-minute walk. The patient underwent follow-up assessments every 2 weeks for a total of 12 weeks. Over this period, the patient exhibited positive responses to treatment, evidenced by notable improvements in glycaemic control. Specifically, fasting blood glucose (FBS) levels decreased to 139 mg/dl, postprandial blood glucose (PPBS) levels dropped to 179 mg/dl, and glycated hemoglobin percentage (HbA1c) decreased to 8.7%. Additionally, there was a significant amelioration in overall symptoms, as evaluated through the Asian Diabetes Quality of Life questionnaire scores and Diabetic Neuropathy Symptom score. At baseline, the AsianDQOL score indicated poor quality of life at 47, which notably improved to 85 post-treatment, indicating a shift towards a good quality of life. Furthermore, the Diabetic Neuropathy Symptom score reduced from 3 at baseline to 0 at the conclusion of treatment, indicative of alleviated pain and burning sensation in the feet. CONCLUSION: This case report highlights the potential effectiveness of Unani medications in managing T2DM, suggesting its viability as a treatment option within a comprehensive diabetes management strategy. The patient's positive response underscores Unani medicine's potential not only as a complementary treatment but also as an integrative approach. However, to substantiate these findings and explore the integration of Unani treatments with conventional therapies, further research, including controlled clinical trials, is imperative. Emphasizing the importance of a multidisciplinary approach, future studies should investigate the mechanisms of action, safety profile, and long-term efficacy of Unani medicine in T2DM management to optimize diabetes care.
Conversation with Greg Cumberford, Vice President, Science and Regulatory Natures Crops International.
Cumberford G, Baker S
Adv Mind Body Med · 2024 · PMID 39213493
Abstract loading — click title to view on PubMed.
Significant Response to Integrated Yoga and Naturopathy Therapies in Post-COVID-19 Neuropathy: A Case Report.
Boopalan D, Vijayakumar V, Ravi P … +1 more , Kuppusamy M
Adv Mind Body Med · 2024 · PMID 39213492
BACKGROUND: The Coronavirus disease (COVID-19) pandemic has been accompanied by a diverse array of neurologic complications attributed to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These comp...
BACKGROUND: The Coronavirus disease (COVID-19) pandemic has been accompanied by a diverse array of neurologic complications attributed to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These complications vary widely, encompassing symptoms such as fatigue, headaches, concentration disturbances, and polyneuropathy-related complaints. Considering the multifaceted nature of these neurological manifestations, exploring alternative and complementary treatment modalities, such as integrated Yoga and Naturopathy interventions, is crucial for enhancing patient outcomes and quality of life. This case report delves into the potential efficacy of such interventions in managing post-COVID neurological complications. CASE PRESENTATION: A 60-year-old male patient presented with peripheral sensory and motor disturbances following a COVID-19 infection. He experienced symptoms such as numbness, pain, and difficulty gripping objects in his right upper limb, emerging 12 weeks after contracting the virus. Clinical examination revealed hypoesthesia and pallhypesthesia in the affected hand. After the onset of neurological symptoms, the patient underwent a 14-day integrated regimen of Yoga and Naturopathy interventions. Clinical and electrophysiological examinations, including nerve conduction studies and grip strength measurements, were conducted before and after the intervention period. RESULTS: After the 14-day integrated Yoga and Naturopathy intervention, the patient demonstrated notable improvements in both subjective and objective measures of neurological symptoms. These improvements suggest a positive response to the treatment regimen and underscore the potential efficacy of integrated, holistic approaches in alleviating post-COVID neurological complications. CONCLUSION: These findings suggest a potential role for integrated Yoga and Naturopathy as effective complementary modalities in managing post-COVID neurological sequelae. However, further empirical studies are warranted to corroborate these findings and explain the broader therapeutic benefits of such interventions in the context of post-COVID-19 disease.
Etiopathogenesis and Management of Prameha Poorvaroopa (Prediabetes), Prameha and Madhumeha (Diabetes Mellitus): An Ancient Perspective.
Kurian J, Bilagi A, Deo G
Adv Mind Body Med · 2024 · PMID 39213491
BACKGROUND: Prameha was identified in 1552 BCE as a Maharoga (major disease), one of the eight grave diseases of Ancient medical history. Initial days of recognition labeled Prameha as a rich man's disease, as found prev...
BACKGROUND: Prameha was identified in 1552 BCE as a Maharoga (major disease), one of the eight grave diseases of Ancient medical history. Initial days of recognition labeled Prameha as a rich man's disease, as found prevalent among people of higher socio-economic background. This fact was thereby linked with the diagnosis of diabetes and the invention of iron in the Iron Age, as wealthy part of the population who initiated consumption of newly harvested rice and wheat were found majorly diagnosed. Gradually, with the knowledge sought from Rigveda, Atharvaveda, Ayurveda, and Samhitas, the causes and types were identified, and further search conducted in Ayurveda resulted in denominating Prameha based on the body constitution and predominant dosha with its etiology in lifestyle and dietary factors, which, in the current scenario is known as diabetes mellitus. OBJECTIVE: The objective of the current review is to find out and collate the information sought from published ancient literature on the origin and classification of Prameha with etiological factors. METHOD: Articles published between 1982 and 2021 in scientific domain was searched using several keywords in PubMed, Google Scholar, and Google, to find treatment approaches adopted by ancient medics to manage Prameha, Madhumeha, and Prameha Poorvaroopa. Classical literature was reviewed to understand the traditional approaches applied in the context of scientific interpretations. Content of this scriptural review was derived mainly from Rigveda, Atharvaveda, Ayurveda, Sushrutha Samhita, Charaka Samhita, Bhela Samhita, Harita Samhita, and Papillad Samhita. SUMMARY: The finding of this study brings hope for further studies evidencing advantages in adopting the ancient wisdom while devising a strategy for the management of Prameha from a modern perspective.
Effect of Yoga and Naturopathy in a Patient with Appendicitis: A Case Report.
Shahana K, Mooventhan A, Menaga S … +2 more , Kayelarasi CA, Soundarapandian P
Adv Mind Body Med · 2024 · PMID 39213490
Appendicitis is the most common condition that affects approximately 233 cases/100 000 people. In general, conventional treatments can often involve invasive procedures, the patients seek alternative therapies for a vari...
Appendicitis is the most common condition that affects approximately 233 cases/100 000 people. In general, conventional treatments can often involve invasive procedures, the patients seek alternative therapies for a variety of reasons, such as preserving the anatomical and functional integrity of the body, fear of surgery, financial issues, etc. A 21-year-old female was diagnosed with appendicitis in October 2015 using ultrasonography of the abdomen visited our hospital. She underwent conventional management for pain in a private hospital for 2-days. Then, she was admitted to a yoga and naturopathy hospital with the symptoms of poor appetite, nausea, vomiting, and diarrhea. The patient received yoga and naturopathy treatments such as warm water enema, cold hip bath, cold abdomen pack, gastro hepatic pack, direct mud application to the abdomen, mud pack to abdomen and eyes, fasting therapy, pranayama and relaxation techniques for 1 week. The patient was advised to undergo ultrasonography of the abdomen after 1 week of treatment. The results showed no sign of appendicitis [i.e., a) no inflammation, b) no dilation of bowel, and c) Bowel movements are seen) compared to the pre-test assessments [i.e., a) evidence of long tubular oedematous, aperistaltic structure with perilesional inflammatory changes, b) Severe probe tenderness, and c) Appendicitis measures 8 mm in size suggestive of acute appendicitis] was noted in the ultrasonography report. In addition, the patient did not report any serious adverse events during the study period. This result suggests that yoga and naturopathy systems of medicine, in addition to conventional pain management during acute (painful) conditions might be useful in cases of appendicitis. However, as the result is based on a single case, further studies with a larger sample size are recommended to warrant the results of this study.
Effects of the Laying on of Hands on Stress, Depression, Fatigue, and Quality of Life in Oncology Patients: A Randomized, Double-Blind Clinical Trial.
Carneiro ÉM, Oliveira LFA, de Fátima Borges M … +1 more , Rodrigues de Oliveira L
Adv Mind Body Med · 2024 · PMID 39213489
CONTEXT: Complementary medicine through the laying on of hands (LOH) is commonly integrated with conventional medicine in cancer patients to improve symptoms. However, studies evaluating the effects of the LOH with Spiri...
CONTEXT: Complementary medicine through the laying on of hands (LOH) is commonly integrated with conventional medicine in cancer patients to improve symptoms. However, studies evaluating the effects of the LOH with Spiritual connection (LHSP) on oncology patients are lacking. OBJECTIVE: This study aimed to investigate the effects of LHSP, and LOH without Spiritual connection (LHW) compared to a control group on the outcomes of oncology patients undergoing chemotherapy. DESIGN: It is a randomized, double-blinded clinical trial. SETTING: The study took place at the Center for Integrative and Complementary Practices of the Federal University of Triangulo Mineiro, MG, Brazil. PARTICIPANTS: Participants were aged ≥18 years with a diagnosis of cancer undergoing parenteral chemotherapy. Those who were unable to understand the questionnaires or were absent during the three therapy sessions were excluded. INTERVENTION: Using block randomization, eligible patients were allocated to one of the following groups: LHSP, receiving LOH by Spiritist "passe"; LHW, receiving LOH with healing intent; and a control group exposed to sham without LOH. Each intervention lasted 5 minutes. Patients were evaluated by a blinded researcher at baseline, at eight, and ten weeks. OUTCOME MEASURES: The outcomes, including stress, anxiety, depression, pain, fatigue, quality of life, vital signs, and adverse effects, were compared among groups. RESULTS: A total of 90 patients with cancer were randomized. After 10 weeks, the LHSP differed significantly from the control for depression (Cohen's d = 1.24), nausea/vomiting (Cohen's d = 0.71), and loss of appetite symptoms (Cohen's d = 0.71); and also to the LHW and control for adverse events (P = 0.023). There were significant differences in depression (Cohen's d = 1.37) and loss of appetite symptoms (Cohen's d = 0.71) between LHW and control. Furthermore, the LHSP and LHW differed significantly from the control for depression (Cohen d = 0.83 and Cohen d = 1.19, respectively) and for stress (Cohen d = 0.62 and Cohen d = 0.74, respectively) in patients with solid tumors. CONCLUSIONS: The present results suggest that LOH treatments can improve the mental and physical symptoms, thus maintaining the quality of life in oncology patients during chemotherapy. However, LHSP was more effective in controlling physical symptoms and safer than LHW and control groups. Further studies exploring biological markers, treatment response, and longer follow-up periods are required across different cancer types.
Mechanism of Thunder-Fire Moxibustion in the Treatment of Meibomian Gland Dysfunction Induced by High-Fat Diet.
Gu Y, Yin J, Shen H … +2 more , Gao W, Wei W
Adv Mind Body Med · 2024 · PMID 39213488
OBJECTIVE: An investigation into whether Thunder-Fire Moxibustion improves Meibomian Gland Dysfunction by activating peroxisome proliferator-activated receptor gamma (PPARγ)-related signaling pathway. METHODS: C57BL/6 mi...
OBJECTIVE: An investigation into whether Thunder-Fire Moxibustion improves Meibomian Gland Dysfunction by activating peroxisome proliferator-activated receptor gamma (PPARγ)-related signaling pathway. METHODS: C57BL/6 mice were randomly divided into a Control Group (CG), model group (MG), Experimental Group (EG), Treatment Group (TG), and GW9662 (GW), with 10 mice in each group. The obstruction of the meibomian gland opening, tear film rupture time, and corneal fluorescein sodium staining were observed. The morphology of the meibomian gland was observed by HE staining. Observations of oil red staining were made on the meibomian gland to determine its oil content. The expression levels of PPARγ, NF-κB p65, Phospho-NF-κB p65 (p-NF-κB), and IL-6 in the meibomian gland were detected by Western blot. The expression of PPARγ, NF-κB p65, p-NF-κB p65, and IL-6 in the meibomian gland was examined by immunofluorescence staining. RESULTS: The results showed that compared to the Control Group, the Model Group mice exhibited an increased Meibomian Gland Orifices Score (MGOS) (P < .01), an increased MG corneal staining (P < .01), a shorter tear film break-up time (P < .01), eyelid atrophy, disordered arrangement of meibomian gland cells, the presence of a large number of immature adipocytes, varying degrees of cellular inflammation and infiltration, a significant reduction in meibomian gland tissue lipids, decreased expressions of MGPPARγ and NF-κB (P < .01), and elevated expressions of phosphorylated NF-κB and IL-6 (P < .01). However, Western medicine, antagonists, and thunder-fire moxibustion were all able to reverse these phenomena observed in the Model Group mice (P < .01), with thunder-fire moxibustion exhibiting the most significant effect (P < .01). CONCLUSION: The thunder-fire moxibustion can induce the differentiation of meibomian gland cells, thereby improving the inflammation response.
A Study to Understand Challenges and Factors that Influence Effective Yoga Interventions for Presbyopia using CLARIFY Guidelines.
Shetty L, Kamath YS, K A … +2 more , Reddy GG, Pentapati KC
Adv Mind Body Med · 2024 · PMID 39213487
The demand for treating diseases using yoga therapy, a Complementary and Alternative Medicine (CAM) treatment, has increased globally. An increase in the research in this yoga area from fewer than 10 research publication...
The demand for treating diseases using yoga therapy, a Complementary and Alternative Medicine (CAM) treatment, has increased globally. An increase in the research in this yoga area from fewer than 10 research publications per year in the 1990s to at least 20 per year after 2010 is evidence of this change in treatment needs over time. The beneficial effect of yoga therapy has been limited to practice in acute care despite its remarkable success in this domain. This is due to many factors that impact the therapy's effectiveness, irrespective of disease indications. However, the prime challenges for its effectiveness lie with the reliability of the yoga trial outcome and reporting. There is a great need to reevaluate the yoga trials' reporting for the reliability of their outcome. This study attempts to address the issue by studying challenges for presbyopia with yoga interventions. Among many indications, progressive vision loss (presbyopia), which occurs due to refractive errors in the ocular region, has scope to be treated effectively with yoga therapies. However, trials for yoga interventions for treating refractive errors have not been studied well. This study was conducted to understand the challenges in yoga therapy trials and its potential to treat presbyopia. The CLARIFY guidelines were used to understand the challenges and factors that impact effective treatment in the current research landscape. We found that trials conducted are not in compliance with the reporting guidelines. Adaptation of CLARIFY guidelines is essential to produce reliable evidence to prescribe yoga therapies to treat refractive errors.
Effect of Yoga and Naturopathy-Based Lifestyle Intervention on Inflammatory Markers on Obese Individuals: A Prospective Randomized Controlled Trial.
Shetty P, Shetty GB, Ashwin VP … +3 more , Yall DR, Rajany T, Nanjeshgowda HL
Adv Mind Body Med · 2024 · PMID 39213486
BACKGROUND: Obesity is characterized by abnormal accumulation of fat in adipose tissue. It is a major risk factor for metabolic syndrome caused by chronic inflammatory changes. Naturopathy and yogic intervention are a ho...
BACKGROUND: Obesity is characterized by abnormal accumulation of fat in adipose tissue. It is a major risk factor for metabolic syndrome caused by chronic inflammatory changes. Naturopathy and yogic intervention are a holistic approach. So, the present study aims to assess the effect of naturopathy and yogic intervention on inflammatory markers among obese individuals. METHODS: In this randomized controlled trial, 262 subjects were recruited and randomized into either an experimental or control group with 131 subjects in each group aged 35 ± 9.6 years in experimental and 39.3 ± 9.6 years in control group. The experimental group received 10 days of naturopathy and yogic treatment. The control group didn't receive any naturopathy or yogic treatment. Complete blood count (CBC) was tested at baseline and after 10 days of intervention. RESULTS: The study showed a significant reduction in white blood cells (WBC), Neutrophils, and Lymphocytes with mean values of 1.63 ± 0.38, 1.14 ± 0.25, 0.4 ± 0.09 and an increase in Platelet lymphocyte ratio (PLR) with mean value 19.84 ± 4.97 respectively with a P < .001 in experiment group when compared to the control group. The experimental group also showed a reduction in Platelet and Neutrophil lymphocyte ratio (NLR) with a mean value of 11.28 ± 3.5 & 0.18 ± 0.03 with a P = .01 when compared to the control group. CONCLUSION: Obesity being a major risk factor for metabolic syndrome could be safely and effectively treated with naturopathy and yogic intervention by alleviating the inflammatory markers.
The Association of Relational Spirituality in an EcoMeditation Course with Flow, Transcendent States, and Professional Productivity.
Church D, Vasudevan A, De Foe A
Adv Mind Body Med · 2024 · PMID 39213485
BACKGROUND: Relational spirituality-a sense of oneness with, or personal connection to, a higher power or greater consciousness-has been associated with positive health outcomes in prior research. An evidence-based medit...
BACKGROUND: Relational spirituality-a sense of oneness with, or personal connection to, a higher power or greater consciousness-has been associated with positive health outcomes in prior research. An evidence-based meditation method called EcoMeditation produces significant improvements in psychological health as well as physiological function. OBJECTIVES: This study places EcoMeditation in the context of relational spirituality to evaluate changes in psychological symptoms and professional productivity associated with transcendent states of consciousness, including those characterized as "flow" and "nonduality." METHODS: Participants (n = 41) were drawn from a convenience sample taking a 21-day online course in which they practiced EcoMeditation along with exercises designed to cultivate personal and relational spirituality. They were assessed pre, post, and at six-month follow-up. RESULTS: Significant reductions in anxiety, depression, and post-traumatic stress disorder (PTSD) were found post-test. These were accompanied by significant increases in happiness, flow, transcendent experiences, and professional-personal productivity. Follow-up indicated that gains in happiness, transcendent experiences, nonduality, and professional-personal productivity were maintained over time. CONCLUSIONS: In addition to the improvements in psychological symptoms identified in previous studies, EcoMeditation in the context of relational spirituality was associated with increases in nondual and transcendent states, as well as greater productivity. Although activities such as meditation are usually associated with elevated consciousness in altered states, they may also produce enhanced productivity and performance in everyday life.
Case Report of 11 Years of Severe Malabsorption, Muscular Atrophy, Seizures, and Immunodeficiency Resolved After Proximal Intercessory Prayer.
Romez C, da Silva AC, Corneliussen C … +2 more , Cunha G, Brown JW
Adv Mind Body Med · 2024 · PMID 38837782
We present the case of 11 years of severe malabsorption, muscular atrophy, seizures, and immunodeficiency resolved after proximal intercessory prayer (PIP). A male infant suffered from severe abdominal pain and impaired...
We present the case of 11 years of severe malabsorption, muscular atrophy, seizures, and immunodeficiency resolved after proximal intercessory prayer (PIP). A male infant suffered from severe abdominal pain and impaired development with the introduction of solid food at age five months. The patient had previously appeared healthy, having been born to term and breastfed. Neocate and total parenteral nutrition (TPN) were prescribed, and the former was removed due to abdominal pain and diarrhea. Ultimately, the patient became completely dependent on TPN. It was concluded that he suffered from chronic, idiopathic, severe malabsorption. Development of neutropenia, hypogamma-globulinemia, and hypotonia was recorded. Medical records document atrophy and progressive deterioration of muscular symptoms. At five years of age, frontal lobe epilepsy was detected. Over the course of the disease, several genetic tests were performed. Doctors tried unsuccessfully to diagnose an underlying condition, with various mitochondriopathies and Shwachman-Diamond syndrome suggested as possible causes, but no prognosis of recovery was given. Eleven years following the initial presentation of symptoms, proximal intercessory prayer (PIP) was administered in a single session. The patient reported no unusual sensations during prayer. However, oral feedings were immediately tolerated without discomfort from that time onward. Post-PIP medical records indicate discontinuation of TPN, seizures, and seizure medications. Progressive improvement in the hematological disorders, BMI, and muscular symptoms was also observed. The present case report describes a novel association between PIP and the lasting resolution of multiple symptoms likely related to a genetic disorder. The results inform ongoing discussions about faith-based practices in health care and suggest the need for additional studies of PIP on health outcomes.
The Effect of Massage on Maternal Role Adaptation in Mothers with Premature Infants.
Shoghi M, Bozorgzad P, Mohammadi R … +1 more , Bagherian M
Adv Mind Body Med · 2024 · PMID 38837781
BACKGROUND: Accepting and adapting the maternal role by mothers with premature infants is complicated. Active participation of mothers in neonate massage may facilitate this process. PRIMARY STUDY OBJECTIVE: Determining...
BACKGROUND: Accepting and adapting the maternal role by mothers with premature infants is complicated. Active participation of mothers in neonate massage may facilitate this process. PRIMARY STUDY OBJECTIVE: Determining the effect of massage on maternal role adaptation in mothers of premature infants admitted to the neonatal intensive care unit (NICU). METHODS/DESIGN: A non-parallel quasi-experimental study with a sequential sampling method. SETTING: This study was done in the NICU of Imam Ali Hospital in Amol City, Iran. PARTICIPANTS: 90 mothers of premature infants hospitalized in the NICU participated in this study. INTERVENTION: The mothers in the intervention group after receiving two training sessions massaged their infant for 15 minutes daily from the third day of hospitalization for 5 consecutive days. PRIMARY OUTCOME MEASURES: A maternal role adaptation questionnaire was used. Participants completed the maternal role adaptation questionnaire 3 times: before, on the fifth day, and 14 days after the first day of intervention. The maternal role adaptation questionnaire was used to assess the maternal role adaptation. The participants of the control group also filled out the questionnaire at similar time. RESULTS: The mean scores of maternal adaptation were significantly different between the two control groups (5th day and 14th day) and intervention (day 5: 136.88 ± 10.062 (P = .025); day 14: 151.93 ± 6 (P < .001)). Maternal role adaptation showed an upward trend in the two groups during the 14 days of study, but this trend was significantly higher in the intervention group over time, compared to the control group. CONCLUSION: Massage of premature infants facilitates the adaptation to maternal role. It is recommended, along with other nursing interventions, to empower mothers with premature neonates admitted to the NICU.
Therapeutic Potential of Recreation on Non-Motor Symptoms in Parkinson's Disease: A Literature Review.
Gharpure V, Parab S, Ryain A … +1 more , Ghosh A
Adv Mind Body Med · 2024 · PMID 38837780
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder of the central nervous system. Non-motor symptoms (NMSs) such as anxiety, depression, sleep disorders, autonomic dysregulation, and sensory...
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder of the central nervous system. Non-motor symptoms (NMSs) such as anxiety, depression, sleep disorders, autonomic dysregulation, and sensory impairments are as debilitating as motor symptoms and negatively impact an individual's quality of life. While the majority appear in the prodromal stage, a few NMSs, like anxiety and hallucinations can also occur as a side effect of dopaminergic drugs. Physical activity-based recreation has emerged as a newer non-pharmacological approach to managing NMS in PD. However, there is a paucity of literature proving its efficacy in reducing NMS burden. PRIMARY OBJECTIVE: The objective of the present review is to summarise evidence on the efficacy of physical activity-based recreation to manage NMSs in PD. METHODS: A literature search was conducted in PubMed, CINAHL, and Cochrane Library databases. Fifty studies including randomized controlled trials, systematic reviews, and cohort studies published between 2012-2022 were reviewed thoroughly as per Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Scoping Review (PRISMA-ScR) guidelines. SETTING: India. PARTICIPANTS: Individuals with PD. RESULTS: Three out of eight studies, one fair quality (level IIa) and two high-quality studies (level Ib and Ia respectively) observed the effects of dance on NMS, two high-quality studies (level Ib) examined the effects of Tai-chi, two high-quality studies (level Ia and Ib respectively) examined the effect of Qigong while the remaining one high-quality study (level Ia) assessed the effects of Yoga. CONCLUSION: Review findings indicate that yoga and Tai-chi followed by Qigong and dance are effective therapeutic adjuncts to regular physiotherapy interventions in alleviating NMSs in individuals with PD.
Nutritional Management of Hashimoto's Thyroiditis: A Case Report.
Whitfield M, Hollywood JB, Keister A
Adv Mind Body Med · 2024 · PMID 38837779
INTRODUCTION: Hashimoto's thyroiditis (HT) is prevalent in about 1 in 1000 people. A 39-year-old female diagnosed with HT was having unsuccessful symptom resolution with conventional thyroxine (T4) replacement therapy. I...
INTRODUCTION: Hashimoto's thyroiditis (HT) is prevalent in about 1 in 1000 people. A 39-year-old female diagnosed with HT was having unsuccessful symptom resolution with conventional thyroxine (T4) replacement therapy. In 60 days, there was a remarkable reduction of thyroid antibodies (Ab), improvement of thyroid hormones, and cardiometabolic biomarkers following a Paleolithic diet (PD). CASE DESCRIPTION: A patient unable to lose weight or alleviate gastrointestinal and neurological symptoms after maintaining clinical thyroid stimulating hormone (TSH) levels through conventional T4 medication therapy saw significant reductions in thyroglobulin (47.5%) and thyroid peroxidase (28.9%) Abs, and significant improvement in TSH (36.4%) total T4 (21.5%) and total T3 (33.3%) after 60-day treatment intervention with the PD. Improvements were also seen in HDL (31.6%), LDL (8.9%), total cholesterol (14.9%), and weight (11.5%). The client adhered to a weekly step process of avoidance of foods that have known hypersensitivities and consumed high-quality fats, fermented foods, filtered water, and green tea, and took a daily nutritional supplementation of vitamin D used in conjunction with a homemade turmeric spice blend. Upon final follow-up, the client had a remarkable reduction in symptoms. CONCLUSION: The Paleolithic diet may be used as a nutritional therapeutic protocol in those with HT with who have complications reducing weight and alleviating gastrointestinal and neurological symptoms no adverse events. Future research should be performed on larger, more diverse populations to develop population-based clinical practice guidelines. Specific areas of research, such as the long-term effects of the PD on HT, comparisons with conventional treatments, and exploring the mechanisms by which PD influences HT symptoms and markers will be beneficial to this research.
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