J Cancer Res Ther [JOURNAL]
Sun
200 papers
Erratum: A multimodal intelligent model for the noninvasive prediction of vascular endothelial growth factor expression and prognostic stratification in breast cancer: A multicenter retrospective study.
J Cancer Res Ther · 2026 May · PMID 42241179 · Publisher ↗
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Erratum: Consensus from the Asian conference on tumor ablation working group on image-guided thermal ablation for lung tumor: 10 key questions and answers.
J Cancer Res Ther · 2026 May · PMID 42241178 · Publisher ↗
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Cryoablation for plantar alveolar soft part sarcoma: A case report.
Zhu B, Liu Y, Li J … +3 more , Diao L, Wang J, Yang W
J Cancer Res Ther · 2026 May · PMID 42241177 · Publisher ↗
Superficial tumors cause pain and bleeding. Treatment not only involves tumor control but must also provide symptom relief and repair tissues. Cryoablation is a safe, effective, and minimally invasive technique used to t...
Superficial tumors cause pain and bleeding. Treatment not only involves tumor control but must also provide symptom relief and repair tissues. Cryoablation is a safe, effective, and minimally invasive technique used to treat malignant tumors. It offers unique advantages in managing superficial tumors. It destroys tumor cell structure via low temperatures, induces necrosis and sloughing of tumor tissue, and reduces tumor burden. Additionally, it enhances the repair of local tissues, promotes wound healing, and improves the patient's quality of life. We report a case of a patient with exophytic alveolar soft part sarcoma on the left foot with multiple metastases. The lesion persisted after radiotherapy, rendering the patient immobile due to pain and bleeding. Following cryoablation, the lesion completely necrotized and sloughed off. Local healing was good, walking was restored, and quality of life improved significantly. Thus, the potential therapeutic benefits of cryoablation against superficial tumors are highlighted.
Efficacy and safety of Xihuang pill/capsule as adjuvant therapy for lung cancer: A systematic review and meta-analysis.
Guan Y, Xiao J, Wang J … +3 more , Liang J, Xie Q, Ye X
J Cancer Res Ther · 2026 May · PMID 42241176 · Publisher ↗
Xihuang Pill/Capsule is a traditional Chinese medicine used to treat cancers, such as breast and lung cancer. This study aimed to evaluate the safety of Xihuang Pill/Capsule and its effect as an adjuvant treatment for lu...
Xihuang Pill/Capsule is a traditional Chinese medicine used to treat cancers, such as breast and lung cancer. This study aimed to evaluate the safety of Xihuang Pill/Capsule and its effect as an adjuvant treatment for lung cancer. A systematic literature search of the Wanfang, VIP, CNKI, Sinomed, PubMed, Embase, Web of Science, and MEDLINE Complete databases was performed to identify randomized controlled trials (RCTs) of Xihuang Pill/Capsule for the adjuvant treatment of lung cancer. Data from the RCTs meeting the inclusion criteria were extracted, assessed for quality using the Cochrane Risk of Bias tool, and statistically analyzed using RevMan version 5.4 software. A total of 23 RCTs (1814 participants) were included. The primary outcomes revealed that Xihuang Pill/Capsule combined with other therapies may increase the objective response rate (ORR; risk ratio [RR] =1.45, 95% confidence interval [CI] [1.33, 1.58], P < 0.00001) and disease control rate (DCR; RR = 1.18, 95% CI [1.12, 1.23], P < 0.00001), and subgroup analyses comparing the ORR and DCR of the different medication forms supported these findings. As secondary outcomes, tumor markers, Karnofsky Performance Status (KPS), T-cell subsets, and most adverse events improved after using Xihuang Pill/Capsule. Based on existing clinical evidence, Xihuang Pill/Capsule combined with conventional therapies improves tumor prognosis, patients' quality of life, and immune function in lung cancer and alleviates some adverse events associated with other antitumor therapies.
Extracellular volume fraction determined by equilibrium contrast-enhanced dual-energy CT as a diagnostic indicator in patients with renal masses.
Tan Y, Dan H, Yang L … +3 more , Zhang Y, Wang L, Zhang J
J Cancer Res Ther · 2026 May · PMID 42241175 · Publisher ↗
PURPOSE: This study aimed to evaluate the feasibility of equilibrium contrast-enhanced dual-energy computed tomography (DECT) compared with tumor single-energy CT (SECT) to calculate the extracellular volume (ECV) fracti...
PURPOSE: This study aimed to evaluate the feasibility of equilibrium contrast-enhanced dual-energy computed tomography (DECT) compared with tumor single-energy CT (SECT) to calculate the extracellular volume (ECV) fraction for differentiation between benign and malignant renal masses. METHODS: The sample included 77 patients with renal masses who underwent DECT between March 2019 and July 2021. Unenhanced and 120-kVp equivalent images were used to calculate tumor SECT-derived ECV fractions. Iodine density images were obtained from equilibrium-phase DECT for calculating DECT-derived ECV fractions. Relationships between SECT- and DECT-derived ECV fractions were examined by Pearson correlation analysis. Consistency between the SECT- and DECT-derived ECV fractions was evaluated using the intraclass correlation coefficient and Bland-Altman analyses. The discrimination performance of ECV for malignant and benign renal masses was compared using the independent sample t-test and receiver operating characteristic curve analysis. RESULTS: The SECT- and DECT-derived ECV fractions were strongly correlated ( r = 0.756, P < 0.001). The Bland-Altman plot of the SECT- and DECT-derived ECV fractions revealed a small bias (-1.6%). The ECV fraction was significantly higher for malignant renal masses than for benign masses (SECT, P < 0.001; DECT, P < 0.001). The area under the curve of DECT-ECV and SECT-ECV was 0.948 and 0.921, respectively. The sensitivity of DECT-ECV and SECT-ECV was 93.65% and 90.48%, respectively, while the specificity was 85.71% and 85.71%, respectively. CONCLUSIONS: Our findings show good correlation between DECT-ECV and SECT-ECV. The ECV fraction determined by equilibrium contrast-enhanced DECT is a potential new imaging marker for differentiating malignant from benign renal masses.
Enhancing non-invasive colorectal cancer screening with stool DNA methylation markers and light gradient-boosting machine learning.
Zhu G, Zhu Y, Lu Z … +6 more , Zheng L, Feng X, Zhu R, Wang X, Xu X, Huang L
J Cancer Res Ther · 2026 May · PMID 42241174 · Publisher ↗
OBJECTIVE: This study evaluated the effectiveness of stool DNA methylation markers Cannabinoid Receptor Type 1 (CNRIP1), Secreted Frizzled-Related Protein 2 (SFRP2), and Vimentin (VIM), along with Fecal Occult Blood Test...
OBJECTIVE: This study evaluated the effectiveness of stool DNA methylation markers Cannabinoid Receptor Type 1 (CNRIP1), Secreted Frizzled-Related Protein 2 (SFRP2), and Vimentin (VIM), along with Fecal Occult Blood Testing (FOBT), in the non-invasive screening for colorectal cancer (CRC), further integrating these markers with the Light Gradient Boosting Machine (LightGBM) machine learning (ML) algorithm. METHODS: The study analyzed 100 stool samples (50 CRC, 50 normal) to assess the methylation status of CNRIP1, SFRP2, and VIM gene promoters. FOBT was performed in parallel. Diagnostic performance was assessed using Receiver Operating Characteristic (ROC) curve analysis, and a LightGBM-based ML model was developed, incorporating methylation markers and FOBT results. RESULTS: ROC analysis demonstrated that SFRP2 had the highest diagnostic accuracy with an area under the curve (AUC) of 0.87 (95% confidence interval [CI]: 0.794-0.946) and a sensitivity of 0.88. CNRIP1 and VIM also showed substantial screening effectiveness, with AUC values of 0.83 and 0.80, respectively. FOBT, in comparison, had a lower predictive value with an AUC of 0.67. The LightGBM-based ML model significantly outperformed individual markers, achieving a high AUC of 0.95 (95% CI: 0.916-0.991). However, the sensitivity of the ML model was 0.78, suggesting a need for improvement in correctly identifying all CRC cases. CONCLUSION: Stool DNA methylation markers CNRIP1, SFRP2, and VIM exhibited high sensitivity in non-invasive CRC screening. The integration of these biomarkers with the LightGBM ML algorithm enhanced diagnostic accuracy, offering a promising approach for early CRC detection.
Combining partial splenic embolization with hepatic artery infusion chemotherapy in the management of chemotherapy-induced hypersplenism in patients with colorectal cancer liver metastases.
Liu B, Gao S, Zheng H … +15 more , Guo J, Kou F, Liu S, Zhang X, Feng A, Wang X, Cao G, Chen H, Liu P, Xu H, Gao Q, Yang R, Xu L, Wu D, Zhu X
J Cancer Res Ther · 2026 May · PMID 42241173 · Publisher ↗
BACKGROUND: While partial splenic artery embolization (PSE) has been effectively employed in treating portal hypertension, cirrhosis, and idiopathic thrombocytopenia, its combination with hepatic artery infusion chemothe...
BACKGROUND: While partial splenic artery embolization (PSE) has been effectively employed in treating portal hypertension, cirrhosis, and idiopathic thrombocytopenia, its combination with hepatic artery infusion chemotherapy (HAIC) for the management of chemotherapy-induced hypersplenism (CIH) has not been previously explored. This retrospective study aims to provide clinical insights into this potential therapeutic approach. MATERIALS AND METHODS: We conducted a retrospective analysis involving patients with colorectal cancer liver metastases (CRLM) who received PSE in conjunction with HAIC (utilizing the FOLFOX regimen) to manage thrombocytopenia due to hypersplenism. Tumor response assessment followed the response evaluation criteria in solid tumors, while adverse reactions were categorized using the Common Terminology Criteria for Adverse Events (version 5.0). The primary objective was to attain a platelet (PLT) count of 100 × 10 9 /L, with secondary objectives encompassing evaluation of adverse events related to the combined therapy and its efficacy against liver metastases. RESULTS: From January 2018 to May 2023, 20 patients with CRLM and CIH were consecutively enrolled in this investigation, each undergoing PSE and HAIC. In total, PSE was performed 25 times. Median pre- and post-PSE PLT counts were 51 × 10 9 /L and 116 × 10 9 /L, respectively, with 80% of participants reaching the primary endpoint of a PLT count of ≥100 × 10 9 /L. Abdominal pain emerged as the most frequent postoperative complication, affecting 11 patients (44%). The objective response rate stood at 25%, while the disease-control rate was reported at 80%. The median progression-free survival was measured at 3.9 months, with a median overall survival of 13.8 months. CONCLUSION: The combination of PSE and HAIC (FOLFOX regimen) represents a safe and effective strategy for managing CIH and CRLM, demonstrating favorable outcomes in PLT count restoration and disease control.
Association between lipid metabolism and lung adenocarcinoma: Evidence from Mendelian randomization and tissue microbiome analysis.
Chen Q, Xu Z, Zheng T … +2 more , Pang H, He Z
J Cancer Res Ther · 2026 May · PMID 42241172 · Publisher ↗
BACKGROUND: Tissue-resident microbiota play an important role in lung cancer development. This study aimed to characterize the microbiota profile associated with fatty acid metabolism and related genes and examine its ef...
BACKGROUND: Tissue-resident microbiota play an important role in lung cancer development. This study aimed to characterize the microbiota profile associated with fatty acid metabolism and related genes and examine its effect on treatment outcomes in lung cancer. METHODS: Genome-wide association data on saturated fatty acid ratio, total cholesterol, and linoleic acid ratio were analyzed with lung adenocarcinoma as the outcome. Mendelian randomization (MR) and multivariable MR using significant single nucleotide polymorphisms assessed causal effects with sensitivity analyses. TCGA and GEO microbial data were explored via GSEA, STRING, and CIBERSORT, and Bacillus velezensis was validated in tumor tissue by quantitative polymerase chain reaction. RESULTS: MR identified saturated fatty acids and total cholesterol as risk factors for lung adenocarcinoma (LUAD), while linoleic acid was protective. Microbial profiling showed distinct tumor versus adjacent tissue communities, with Bacillus velezensis enriched in LUAD. Its abundance was negatively associated with the cholesterol-response pathway (GOBP_CELLULAR_RESPONSE_TO_CHOLESTEROL). Twelve cholesterol-related genes were differentially expressed, and a derived risk model predicted poor prognosis. Among them, GPLD1 exhibited tumor-suppressor characteristics, with lower tumor expression linked to worse survival. GPLD1 is detectable in plasma (~2.8 mg/L) and reduced in lung cancer patients, supporting its potential as a noninvasive biomarker. CONCLUSION: Our findings suggest a causal link between the components of a high-fat diet and LUAD by identifying key genes and microbial communities. Moreover, GPLD1 represents a promising biomarker for the early diagnosis and prognosis of this patient population.
BATF in CD8 + T cells from patients with myelodysplastic syndromes.
Han D, Li Y, Zhong K … +1 more , Shao Z
J Cancer Res Ther · 2026 May · PMID 42241171 · Publisher ↗
BACKGROUND: Myelodysplastic syndromes (MDS) are a group of hematopoietic disorders characterized by bone marrow failure and immune dysregulation. Dysregulated CD8 + T-cell function contributes to the pathogenesis of MDS....
BACKGROUND: Myelodysplastic syndromes (MDS) are a group of hematopoietic disorders characterized by bone marrow failure and immune dysregulation. Dysregulated CD8 + T-cell function contributes to the pathogenesis of MDS. Basic Leucine Zipper ATF-Like Transcription Factor ( BATF ) is a key regulator of T-cell differentiation and exhaustion. This study investigated the role of BATF in CD8 + T cells from MDS patients and its correlation with clinical parameters. METHODS: Twenty-one newly diagnosed MDS patients and healthy controls were enrolled in this study. The expression of BATF , perforin, granzyme B, and TIM-3 in peripheral blood CD8 + T cells was analyzed by flow cytometry. BATF mRNA levels were quantified by real-time PCR. Correlations between BATF expression and clinical data were evaluated statistically. RESULTS: Flow cytometry analysis revealed that BATF protein expression was significantly elevated in CD8 + T cells from higher-risk MDS patients compared with that in lower-risk patients and healthy controls, although BATF mRNA levels showed no significant difference. Functionally, BATF expression was inversely correlated with perforin expression and positively correlated with the exhaustion marker TIM-3. Clinically, BATF expression in CD8 + T cells was negatively correlated with hemoglobin concentration in MDS patients. CONCLUSIONS: Our findings suggest that BATF may promote CD8 + T-cell exhaustion and dysfunction in MDS, potentially contributing to anemia and disease progression. Targeting BATF could represent a novel therapeutic strategy for restoring immune function in MDS.
Prognostic value of sarcopenia in patients undergoing postesophagectomy adjuvant chemotherapy.
Peng H, Gu P, Xu Z … +4 more , Lu D, Peng M, Yang N, Zheng B
J Cancer Res Ther · 2026 May · PMID 42241170 · Publisher ↗
OBJECTIVE: To evaluate the correlation of sarcopenia and systemic inflammation indicators with nutritional status and the prognostic value of sarcopenia in patients undergoing adjuvant chemotherapy after esophageal cance...
OBJECTIVE: To evaluate the correlation of sarcopenia and systemic inflammation indicators with nutritional status and the prognostic value of sarcopenia in patients undergoing adjuvant chemotherapy after esophageal cancer (EC) surgery. MATERIALS AND METHODS: The clinical data of 78 patients with EC who underwent adjuvant chemotherapy after surgery were collected, and the following metrics were calculated: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), fibrinogen/prealbumin ratio (FPR), albumin/fibrinogen ratio, Geriatric Nutritional Risk Index (GNRI), and Prognostic Nutritional Index. RESULTS: Of the 78 patients with EC, 50 (64.10%) were diagnosed with sarcopenia. Logistic regression analysis demonstrated that sarcopenia was significantly associated with cancer embolus, GNRI, FPR, NLR, PLR, and body mass index. Survival analysis showed that patients with sarcopenia had significantly worse overall survival. Univariate and multivariate survival analysis showed that lymphatic metastasis and sarcopenia were independent factors affecting prognosis. CONCLUSION: Sarcopenia is significantly related to lymphatic metastasis, systemic inflammation indicators, and nutritional status. Sarcopenia can serve as a good prognostic factor in patients undergoing adjuvant chemotherapy after EC surgery.
A study on the antitumor effect and mechanism of arsenic trioxide on lung adenocarcinoma.
Zheng Q, Liu H, Zhang Q … +6 more , Guo N, Luo Q, Yang S, Zhang S, Chen X, Li N
J Cancer Res Ther · 2026 May · PMID 42241169 · Publisher ↗
BACKGROUND: Lung adenocarcinoma is a common malignancy that requires new treatments. Arsenic trioxide (ATO) exerts antitumor activity in various cancers; however, its mechanisms of action in lung adenocarcinoma remain un...
BACKGROUND: Lung adenocarcinoma is a common malignancy that requires new treatments. Arsenic trioxide (ATO) exerts antitumor activity in various cancers; however, its mechanisms of action in lung adenocarcinoma remain unclear. METHODS: The 24-h half-maximal inhibitory concentration (IC50) of ATO on human lung adenocarcinoma A549 cells was determined using the Cell Counting Kit-8 assay. Cells were treated with the IC50 concentration in the experimental group, and untreated cells served as the control group. A comparative assessment of cell proliferation, apoptosis, invasion, and migration was performed. Transcriptome sequencing followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to identify differentially expressed genes and enriched pathways. Candidate pathway proteins were validated by western blot analysis. RESULTS: The 24-h IC50 of ATO was 99.12 μmol/L. The ATO-treated group exhibited reduced proliferation, increased apoptosis, and decreased invasion and migration ( P < 0.05) compared with that in the control group. Transcriptome analysis revealed 4,522 upregulated and 4,045 downregulated genes, with enrichment in the mammalian target of rapamycin (mTOR) signaling pathway, base excision repair (BER), and apoptosis pathways. At the protein level, total mTOR expression did not significantly change, whereas phosphorylated mTOR (p-mTOR), APE-1, Bcl-2, and Bcl-XL were downregulated, and cleaved caspase-8 and cleaved caspase-9 were upregulated ( P < 0.05). DISCUSSION: These results indicate that ATO suppresses the malignant phenotype of A549 cells by inhibiting mTOR phosphorylation, downregulating key BER components, and activating the extrinsic and intrinsic apoptotic pathways, providing experimental evidence for further studies of ATO in lung adenocarcinoma therapy.
CEUS features-based nomogram for predicting early recurrence (ER) of microvascular invasion-negative hepatocellular carcinoma.
Shu Q, Liu Y, Pang C … +7 more , Wang Z, Tian X, Wang S, Yan X, Liang P, Yu J, Yu X
J Cancer Res Ther · 2026 May · PMID 42241168 · Publisher ↗
PURPOSE: This study aimed to investigate contrast-enhanced ultrasound (CEUS) and clinical features associated with early recurrence (ER) following surgical resection in patients with microvascular invasion (MVI)-negative...
PURPOSE: This study aimed to investigate contrast-enhanced ultrasound (CEUS) and clinical features associated with early recurrence (ER) following surgical resection in patients with microvascular invasion (MVI)-negative hepatocellular carcinoma (HCC), and to establish a nomogram-based predictive model. METHODS: A total of 146 pathologically confirmed MVI-negative HCC patients were retrospectively enrolled between August 2021 and June 2024. Univariable and multivariable Cox regression analyses were performed based on CEUS and clinicopathologic variables to identify predictors and develop a nomogram for 2-year recurrence probability. Model performance and discriminative ability were evaluated using the concordance index (C-index), receiver operating characteristic curve, and decision curve analysis (DCA). RESULTS: Multivariable Cox analysis identified smooth morphology, intra-tumoral artery, glypican-3 expression, and albumin-bilirubin (ALBI) grade as independent predictors of ER (all P < 0.05). A nomogram incorporating CEUS and clinicopathologic variables was constructed and demonstrated a favorable C-index of 0.768 (95% confidence interval [CI], 0.711-0.817). The model showed strong discriminative ability, with an area under the curve of 0.870 (95% CI, 0.805-0.952), and DCA indicated good clinical utility. The derived risk score effectively stratified patients into high-risk and low-risk groups. Patients in the low-risk group exhibited significantly better prognosis compared with those in the high-risk group ( P < 0.001). CONCLUSIONS: This CEUS- and clinicopathology-based prognostic model accurately identifies high-risk MVI-negative HCC patients and may provide valuable information for optimizing surveillance and intervention strategies.
Thermal ablation versus hepatectomy in patients with liver metastases from RAS-mutated colorectal cancer.
Wen C, Zhou C, Chen S … +3 more , Shen L, Li C, Fan W
J Cancer Res Ther · 2026 May · PMID 42241167 · Publisher ↗
OBJECTIVE: To compare the efficacy and safety of thermal ablation therapy and hepatectomy in patients with RAS-mutated colorectal liver metastases (CRLMs). MATERIALS AND METHODS: A 1:1 propensity score matching (PSM) ana...
OBJECTIVE: To compare the efficacy and safety of thermal ablation therapy and hepatectomy in patients with RAS-mutated colorectal liver metastases (CRLMs). MATERIALS AND METHODS: A 1:1 propensity score matching (PSM) analysis was conducted to categorize patients into thermal ablation and hepatectomy groups with comparable propensity scores. Progression-free survival (PFS) was determined by the Kaplan-Meier method. A Cox regression model was used to examine the prognostic factors. RESULTS: Following PSM analysis, 38 pairs of patients were enrolled into two groups. Before PSM, the median PFS in the thermal ablation group was longer compared with that in the hepatectomy group (14.0 vs. 10.0 months, P = 0.075). A statistically significant difference was observed following PSM, with the median PFS of patients in the thermal ablation group being significantly longer compared with that in the hepatectomy group (13.0 vs. 9.0 months, P = 0.021). The results of the multifactorial analysis of the Cox regression demonstrated that the treatment modality (thermal ablation/hepatectomy) was an independent prognostic factor that affects PFS ( P < 0.05). The postoperative recurrence rates of the two groups were not significantly different before and after PSM. Regarding treatment safety, complications were significantly more prevalent in the hepatectomy group compared with that in the ablation treatment group before PSM ( P = 0.003), whereas no significant difference in complications was observed between the two groups following PSM ( P = 0.169). CONCLUSION: Thermal tumor ablation is a favorable treatment option for patients with RAS-mutated CRLM, particularly for those with tumors of specific size ranges (≤5 cm) and an appropriate tumor burden.
Correlation between super-resolution ultrasound imaging features and microvascular invasion in hepatocellular carcinoma.
Chen C, Li X, An S … +6 more , Pang C, Li M, Zhu Z, Wan M, Zong Y, Liang P
J Cancer Res Ther · 2026 May · PMID 42241166 · Publisher ↗
BACKGROUND: Microvascular invasion (MVI) is a critical histopathological determinant of poor prognosis in hepatocellular carcinoma (HCC). Conventional imaging modalities remain limited in their ability to depict microvas...
BACKGROUND: Microvascular invasion (MVI) is a critical histopathological determinant of poor prognosis in hepatocellular carcinoma (HCC). Conventional imaging modalities remain limited in their ability to depict microvascular architecture or quantify vascular parameters in vivo . Super-resolution ultrasound (SR-US), based on ultrasound localization microscopy (ULM), facilitates the visualization and quantitative assessment of intratumoral microvasculature beyond the diffraction limit, even in deep hepatic lesions. This study aimed to evaluate the clinical feasibility of SR-US in patients with HCC and explore the relationship between quantitative vascular parameters and MVI. METHODS: Patients with pathologically confirmed HCC who underwent preoperative SR-US were prospectively enrolled. Microbubble tracking was performed using ULM to reconstruct super-resolution microvascular maps. Quantitative vascular parameters-including vessel density, flow velocity, complexity, and perfusion index-were extracted. MVI status was obtained from surgical pathology. Comparative analyses were conducted using Student's t-tests and Chi-square tests. RESULTS: SR-US was successfully performed in 70 patients. Quantitative analysis revealed that the complexity of the entire tumor was significantly higher in the non-MVI group than in the MVI group (1.63 ± 0.70 vs. 1.59 ± 0.52, P = 0.024). A similar trend was observed in tumor center complexity (1.57 ± 0.94 vs. 1.51 ± 0.77, P = 0.004). No significant between-group differences were found in perfusion index, microbubble density, or microbubble velocity (all P > 0.05). CONCLUSION: SR-US is a feasible, noninvasive technique for visualizing and quantifying intratumoral microvasculature in human HCC. Its quantitative parameters, particularly complexity, are significantly associated with MVI, demonstrating its potential for preoperative risk stratification in clinical settings.
Heat induces pyroptosis in human normal lung epithelial cells and lung cancer cells via caspase-3/GSDME activation.
Liu P, Sang J, Wang M … +6 more , Wang N, Xu F, Ma J, Xie Q, Wei Z, Ye X
J Cancer Res Ther · 2026 May · PMID 42241165 · Publisher ↗
BACKGROUND: Hyperthermia (including thermal ablation and whole-body hyperthermia) is one of the methods to treat lung tumor. The primary mechanism underlying this method involves causing tumor cell necrosis, apoptosis, a...
BACKGROUND: Hyperthermia (including thermal ablation and whole-body hyperthermia) is one of the methods to treat lung tumor. The primary mechanism underlying this method involves causing tumor cell necrosis, apoptosis, and pyroptosis. Pyroptosis can trigger a series of inflammatory reactions and serves as a contributing factor to lung injury. The objective of this study was to investigate whether hyperthermia can induce pyroptosis of normal lung epithelial cells, while concurrently triggering pyroptosis of lung tumor cells. MATERIALS AND METHODS: The cell lines PC-9 and BEAS-2B used in this study represent lung tumor cells and normal lung epithelial cells, respectively. PC-9 and BEAS-2B cells was simulated with a 45°C thermostatic water bath in vitro . Cell morphological characteristics were observed using microscopy. Gene expressions were evaluated by quantitative real-time PCR and protein expressions were assessed using Western blotting. RESULTS: Heat stress induced morphological features of pyroptosis in BEAS-2B and PC-9 cells and upregulated pyroptosis-related gene expressions ( GSDMD, GSDME, caspase-1, caspase-3, IL-1β , and IL-18 ) in both cells. Also, heat stress resulted in an upregulation of cleaved GSDME but not cleaved GSDMD in BEAS-2B and PC-9 cells and increased cleaved GSDME can be efficiently abrogated by inhibition of caspase-3. CONCLUSION: Heat induces pyroptosis in BEAS-2B and PC-9 cells, and the mechanism of pyroptosis induction is realized through the GSDME/caspase-3 pathway. The results showed hyperthermia can induce pyroptosis of lung cancer cells as well as normal lung epithelial cells at the same time. This might provide a potential target for prevention and treatment of lung injury after hyperthermia.
Percutaneous radiofrequency ablation of ground-glass nodules like lung cancer ~ 5-year follow-up.
Li Y, Feng X, Zhou H … +3 more , Chen J, Chen W, Lin Z
J Cancer Res Ther · 2026 May · PMID 42241164 · Publisher ↗
OBJECTIVE: To explore the clinical efficacy of radiofrequency ablation (RFA) for treating radiologically noninvasive lung cancer (RNILC), defined as ground-glass nodules (GGNs) ≤20 mm in diameter with a consolidation-to-...
OBJECTIVE: To explore the clinical efficacy of radiofrequency ablation (RFA) for treating radiologically noninvasive lung cancer (RNILC), defined as ground-glass nodules (GGNs) ≤20 mm in diameter with a consolidation-to-tumor ratio (CTR) ≤0.25. METHODS: We investigated 24 consecutive patients (12 men and 12 women) with 30 pulmonary GGNs who presented as RNILC and underwent RFA from July 2011 to April 2016. Safety, feasibility, effectiveness, and survival were evaluated. RESULTS: The mean nodule diameter was 9.5 ± 3.6 mm, with a mean CTR of 4.8% ±7.8%. The technical success rate was 100%, and no major complications were observed. The median follow-up period was 65.3 ± 8.2 months, with no nodules showing evidence of disease progression. The 5-year cancer-specific survival and local progression-free survival rates were both 100%. Furthermore, 5-year overall survival was 100.0%. CONCLUSION: RFA treatment for GGNs diagnosed as RNILC was safe and effective, with promising survival rates.
Diagnostic accuracy of dual-phase cone-beam computed tomography for celiac arteriography in patients with hepatocellular carcinoma: Comparison with preoperative dynamic contrast-enhanced magnetic resonance imaging.
Guan W, Hu H, Guo C … +7 more , Yuan H, Xu C, Zheng B, Fan W, Song H, Wang W, Zheng L
J Cancer Res Ther · 2026 May · PMID 42241163 · Publisher ↗
OBJECTIVES: The diagnostic accuracy of dual-phase cone-beam computed tomography (DP-CBCT) via celiac arteriography during transarterial chemoembolization (TACE) was compared with preprocedural dynamic contrast-enhanced m...
OBJECTIVES: The diagnostic accuracy of dual-phase cone-beam computed tomography (DP-CBCT) via celiac arteriography during transarterial chemoembolization (TACE) was compared with preprocedural dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for detecting and characterizing hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A total of 67 patients with HCC were enrolled who underwent TACE. Patients first underwent angiography after catheter placement in the celiac trunk, followed by DP-CBCT scanning. Finally, they received TACE, during which lipiodol was administered to mark the lesion. Lipiodol computed tomography (CT) was acquired one week after TACE and served as a reference for assessing the detection of intrahepatic lesions compared with preoperative DCE-MRI and DP-CBCT. RESULTS: Using lipiodol CT as a reference, 172 HCC tumors were detected, including 167 by DP-CBCT and 136 by DCE-MRI. DP-CBCT showed superior diagnostic performance compared with DCE-MRI, with a higher sensitivity (95.9% vs. 76.7%), specificity (60.0% vs. 20.0%), accuracy (94.9% vs. 75.1%), and comparable precision (98.8% vs. 97.1%), respectively. The average lesion diameter was 33.14 mm in the DP-CBCT portal venous phase and 31.10 mm in the DCE-MRI portal venous phase. Compared with lipiodol CT, DCE-MRI had a different Barcelona Clinic Liver Cancer stage in 20.9% of patients compared with only 1.5% for DP-CBCT. CONCLUSIONS: DP-CBCT administered during celiac arteriography contributes to the accurate diagnosis of HCC.
Association between tissue origin classification and the clinical features and molecular phenotypes of nonsmall cell lung cancer.
Zhou P, Tang R, Liu H … +7 more , Wang N, Guo X, Qi H, Cheng Y, Jiang N, Qiu L, Sun Q
J Cancer Res Ther · 2026 May · PMID 42241162 · Publisher ↗
BACKGROUND: Lung cancer is the most common malignancy in humans and the leading cause of cancer-related deaths worldwide. Nonsmall cell lung cancer (NSCLC), the primary histologic type, is categorized into lung adenocarc...
BACKGROUND: Lung cancer is the most common malignancy in humans and the leading cause of cancer-related deaths worldwide. Nonsmall cell lung cancer (NSCLC), the primary histologic type, is categorized into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma based on immunohistochemical thyroid transcription factor-1 and P40 status. LUAD is morphologically classified into five histological subtypes, based on physician experience, which can lead to confusion among pathologists and clinicians. Histological subtypes serve as crucial markers for lung cancer development and hold significant clinical value for cancer diagnosis, prognosis, and treatment response prediction. AIM: Identifying the various subtypes of NSCLC has become pivotal for enhancing diagnostic standards and patient prognosis. METHODS AND RESULTS: In this study, we proposed a novel classification of NSCLC tissues into five subtypes (bronchial epithelial carcinoma, bronchiolar alveolar carcinoma, alveolar cell carcinoma, secretory adenocarcinoma, and mucinous adenocarcinoma) based on tissue origin. Furthermore, mRNA chip screening and next-generation sequencing revealed that these five subtypes exhibit distinct gene expression patterns and mutation signatures. CONCLUSION: This study proposes a novel NSCLC classification model designed to incorporate gene signatures into tissue origin-based histopathological subtypes, complementing the World Health Organization classification, and enhancing both diagnostic accuracy and clinical practicability.
Development of a nomogram to predict subsyndromal delirium in patients with cancer admitted to the intensive care unit.
Li N, Zha Z, Zhang W … +1 more , Ji H
J Cancer Res Ther · 2026 May · PMID 42241161 · Publisher ↗
BACKGROUND: Subsyndromal delirium (SSD) is a prevalent condition that significantly affects the prognosis of patients with cancer admitted to the intensive care unit (ICU). However, a validated nomogram to predict the ri...
BACKGROUND: Subsyndromal delirium (SSD) is a prevalent condition that significantly affects the prognosis of patients with cancer admitted to the intensive care unit (ICU). However, a validated nomogram to predict the risk of SSD in this vulnerable population remains lacking. METHODS: This study included 258 middle-aged and older patients with cancer admitted to the ICU postoperatively. Logistic regression analysis was conducted to determine risk factors for SSD. These factors were integrated into a nomogram model for prediction. The area under the receiver operating characteristic curve (AUC), calibration plot, and decision curve analysis were used to assess the model's performance. The research adhered to TRIPOD guidelines. RESULTS: A total of 58 patients (22.48%) developed SSD. Multivariate logistic regression identified sex, marital status, American Society of Anesthesiologists grade, hypotension, mechanical ventilation (hours), admission source, and serum potassium as independent risk factors for SSD in middle-aged and older patients with cancer in the ICU. The nomogram constructed from these variables achieved an AUC of 0.837 (95% confidence interval, 0.778-0.897). Internal validation demonstrated strong calibration and high clinical use of the model. CONCLUSION: Middle-aged and older patients with cancer are at increased risk of developing SSD after postoperative transfer to the ICU. The nomogram developed in this study provides an effective tool for clinicians to identify high-risk patients at an early stage.
Chinese expert consensus: Radioactive iodine-125 seed interstitial brachytherapy for retroperitoneal lymph node metastases (2024 edition).
Wang J, Zhang H, Zhang F … +27 more , Guo J, Wang J, Wang Z, Li Y, Huang X, Ye X, Gai B, Li X, Lu J, Gao F, Wang R, Hu X, Yang H, Xiao Y, Niu H, Han X, Jiao D, Li C, Lei G, Shao H, Yu H, Yu Y, Wang G, Chang X, Zhai B, Zhu X, Liang Y
J Cancer Res Ther · 2026 May · PMID 42241160 · Publisher ↗
OBJECTIVE: In order to standardize the operational techniques for 125I seed interstitial brachytherapy for retroperitoneal lymph node metastases, we organized multidisciplinary experts to develop the ". CHINESE EXPERT CO...
OBJECTIVE: In order to standardize the operational techniques for 125I seed interstitial brachytherapy for retroperitoneal lymph node metastases, we organized multidisciplinary experts to develop the ". CHINESE EXPERT CONSENSUS: radioactive iodine 125 seed interstitial brachytherapy for retroperitoneal lymph node metastases (2024 edition)." METHOD: In the development of this consensus, we convened a multidisciplinary panel of leading Chinese medical experts specializing in seeds implantation from the fields of radiation oncology, surgery, interventional radiology, Department of Medical Oncology, ultrasonography, and nuclear medicine. THE PROCESS PROCEEDED AS FOLLOWS: first, a literature search was conducted using keywords such as "iodine 125 seed implantation," "interstitial brachytherapy," "retroperitoneal lymph node metastases," "computed tomography-guided," and "125I seeds." Based on the reviewed literature and extensive clinical experience, the writing committee drafted the initial document. This draft was then distributed to all panel members for broad feedback and suggestions. Finally, a centralized discussion was held to integrate the collective expertise and finalize the consensus statements. RESULT: The main contents of this consensus include indications, contraindications, implantation methods, puncture paths, dosage, surgical procedures, and other key points. CONCLUSION: This consensus document demonstrates a high degree of scientific rigor and practical applicability. It is designed to provide clinical guidance for the implementation of 125I seed brachytherapy for retroperitoneal lymph node metastases. By establishing clear, evidence-based recommendations, it aims to serve as a reliable reference for clinicians, nurses, and medical physicists involved in the procedure. Ultimately, this consensus seeks to enhance the standardization and procedural homogeneity of 125I seed brachytherapy for retroperitoneal lymph node metastases across different clinical settings.
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