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The Journal Of Oral Implantology[JOURNAL]

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A Novel Autologous Root Slice Replantation Technique Applied for Immediate Implantation of Maxillary Central Incisors: A Case Report With 6-Year Review.

Shi S, Zang Y, Kou N … +2 more , Ma G, Zhong W

J Oral Implantol · 2026 Jun · PMID 42242698 · Publisher ↗

This case study describes a novel approach to autologous tooth transplantation combined with immediate implantation. This article presents a 6-year follow-up observation of a 22-year-old male patient who requested oral i... This case study describes a novel approach to autologous tooth transplantation combined with immediate implantation. This article presents a 6-year follow-up observation of a 22-year-old male patient who requested oral implant restoration after a fracture of the maxillary anterior tooth caused by trauma. Treatment involved immediate implantation of the maxillary central incisors using a novel autologous tooth transplantation technique called autologous root slice replantation (ARSR). It avoided the absorption of soft and hard tissues on the labial side after immediate implantation of the maxillary anterior teeth. Moreover, the implant area and its surrounding soft tissues were healthy without obvious inflammation. The ARSR develops the application of autologous tooth transplantation combined with immediate implantation, providing a new solution for esthetic implantation in the anterior teeth area.

Bone Regeneration Techniques for Dental Implant Placement Comparing the Effect of Graft Material on Bone Volume and Long-Term Graft Stability: A Systematic Review.

Hindocha MH, Iqbal O, King EM

J Oral Implantol · 2026 Jun · PMID 42242697 · Publisher ↗

The natural physiological bone resorption following tooth loss often results in reduced bone volume to place dental implants in a restoratively driven position. Bone regeneration procedures such as guided bone regenerati... The natural physiological bone resorption following tooth loss often results in reduced bone volume to place dental implants in a restoratively driven position. Bone regeneration procedures such as guided bone regeneration (GBR), sinus augmentation (SA), and alveolar ridge preservation (ARP) have therefore been developed to promote new bone formation. These procedures utilize bone grafting materials of which there are four types, namely, autogenous, allograft, xenograft, and alloplastic grafts. However, there is still no consensus on which material is superior. This systematic review aimed to analyze the current literature to compare alloplastic bone graft materials with autogenous bone, allograft, and xenograft materials when used in GBR, SA, and ARP to determine which is superior. Electronic searches were performed on MEDLINE, Embase, and CENTRAL, along with manual searches to identify relevant randomized control trials and controlled clinical trials. Fifty-three studies were included. Although variations in the methods used between the studies prevented direct comparisons of the outcomes, overall, alloplastic materials were found to have osteoconductive properties, showing promising results with augmentation and preservation of alveolar ridge volume. Clinical parameters were also largely comparable with other graft materials. Alloplastic materials show promising results, with biphasic calcium phosphate being the most studied at present. There are many potential advantages to alloplastic grafts compared with the other materials; however, due to the lack of high-quality evidence in this review, definitive conclusions on which material is superior was not possible, and further research is required.

Preemptive Analgesia With Steroidal and Nonsteroidal Anti-Inflammatory Drugs in Dental Implant Surgeries: A Systematic Review.

Gomes da Frota E, Bergamaschi CC, Lopes LC … +2 more , de Deus Lages LP, Motta RHL

J Oral Implantol · 2026 Jun · PMID 42242696 · Publisher ↗

This systematic review aimed to evaluate the efficacy and safety of preemptive analgesia using oral steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) in adults undergoing dental implant surgery. A comprehensive... This systematic review aimed to evaluate the efficacy and safety of preemptive analgesia using oral steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) in adults undergoing dental implant surgery. A comprehensive search was conducted in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (via PubMed), Excerpta Medica Database (EMBASE), Virtual Health Library (VHL), Web of Science, and other databases with no restrictions on language or publication date. Randomized clinical trials (RCTs) comparing oral steroidal drugs or NSAIDs with placebo or other anti-inflammatory drugs were included. The primary outcomes were postoperative pain, edema, trismus, discomfort, and use of rescue medication. Pairs of reviewers independently extracted data and assessed the risk of bias. Owing to clinical heterogeneity among the included studies, a narrative synthesis was conducted. Seven RCTs (n = 589 patients) evaluated aceclofenac 100 mg (in combination with acetaminophen), dexamethasone 4 mg, dexketoprofen 25 mg, etoricoxib 90 mg, ibuprofen 600 mg, ketorolac 10 mg, meloxicam 15 mg, nimesulide 100 mg, piroxicam 40 mg, and tenoxicam 20 mg. Favorable results have been reported with etoricoxib 90 mg, ibuprofen 600 mg, and nimesulide 100 mg for controlling postoperative pain and discomfort in single-implant procedures. Meloxicam and tenoxicam have demonstrated efficacy in invasive surgeries involving multiple implants and advanced techniques. Some studies have extended anti-inflammatory use to the postoperative period beyond rescue medication, potentially biasing the interpretation of preemptive efficacy. To date, no adverse drug reactions have been reported. Owing to the heterogeneity in protocols, drug regimens, and outcome measures, definitive conclusions regarding the most effective and safest preemptive agents could not be drawn. Future trials should emphasize methodological standardization and focus on widely used drugs to support evidence-based decisions in implant dentistry.

Recruitment of Rat Bone Marrow-Derived Cells to Dental Implants Immediately After Installation.

Zhang T, Nagasawa M, Koide H … +3 more , Kooanantkul C, Nila T, Uoshima K

J Oral Implantol · 2026 Jun · PMID 42242694 · Publisher ↗

This study investigated the recruitment of bone marrow-derived cells (BMDCs) to the implant surface during the osseointegration process. Green fluorescent protein (GFP)-expressing BMDCs were transplanted into irradiated... This study investigated the recruitment of bone marrow-derived cells (BMDCs) to the implant surface during the osseointegration process. Green fluorescent protein (GFP)-expressing BMDCs were transplanted into irradiated Sprague-Dawley rats to trace BMDCs following tooth extraction healing. After bone marrow transplantation, the control group exhibited maxillary bone cavities only, whereas the experimental group received implants in these cavities bilaterally. At 1, 3, 5, and 24 hours postoperation, samples were prepared for immunohistochemical staining. At 24 hours postimplantation, the cells were collected from the implant sites and analyzed using double fluorescence staining. In the experimental group, the number of GFP-positive cells gradually increased over time and was significantly greater than that in the control group at the 3- and 24-hour time points. At 24 hours after implantation, the cells around the implant surface were analyzed. Hematopoietic stem cell markers and mesenchymal stem cell markers were detected in the GFP-positive cells. These data showed that bone marrow-derived cells are recruited to the implant surface in the rats' maxillae. These findings also suggest that hematopoietic stem cells and mesenchymal stem cells derived from bone marrow are important for the establishment of osseointegration in the rats' maxillae in the very early stages. The limitations of this study include its small sample size and relatively short observation period. Future research should involve an increased number of samples and a longer observation timeline. Furthermore, investigating how these cells undergo differentiation over time is necessary.

Impact of Operator Experience on Accuracy and Procedure Time in Dynamic Navigation, Static-Guided, Freehand Implant Placement: An In Vitro Study.

Inoue K, Hasler O, Struwe M … +4 more , Leontiev W, Dagassan-Berndt D, Kühl S, Herber V

J Oral Implantol · 2026 Jun · PMID 42242693 · Publisher ↗

Dynamic navigation systems offer significant potential to enhance dental implant surgery, particularly for novice surgeons. To compare the accuracy and time consumption of freehand implant surgery (group A), static compu... Dynamic navigation systems offer significant potential to enhance dental implant surgery, particularly for novice surgeons. To compare the accuracy and time consumption of freehand implant surgery (group A), static computer-assisted implant surgery (sCAIS; group B), and dynamic computer-assisted implant surgery (dCAIS; group C) performed by novice and experienced surgeons in vitro. A total of 192 implants (n = 192) were placed in polyurethane mandibular models under simulated clinical conditions by 16 participants, divided into 2 groups. Implants were placed after CBCT-based virtual planning. Postoperative surface scans were superimposed on the preoperative planning data to evaluate the angular and spatial deviations. A linear mixed model analysis, followed by descriptive statistics, was used to determine the influence of experience level, method, and operative site on various accuracy parameters. The applied implant placement methodology showed a statistically significant influence on the angular deviation, the 3D deviation at the base and tip, the bucco-oral and mesial-distal deviation at the implant base (P < .05). The lowest mean angular deviation was recorded in group B with 3.12° (±1.49°). The regions where the implants were placed had a significant influence on the angular deviation parameter (P < .001). The level of experience showed a statistically significant difference in the angular deviation of the placed implants (P < .001) and in the bucco-oral deviation at the implant tip (P = .04). Novice surgeons consistently required significantly more time compared with experienced surgeons. Both CAIS approaches hold potential to improve implant placement outcomes, showing significant improvements over freehand techniques.

Implant Education: Practical Hands-On Training.

Wehrle M, Rutkowski JL

J Oral Implantol · 2026 Jun · PMID 42242692 · Publisher ↗

Abstract loading — click title to view on PubMed.

Placement of Dental Implants and Other Type of Implantations in Patients With Schizophrenia: A Review.

Shah S, Jonas KG, Romanos G

J Oral Implantol · 2026 Jun · PMID 42242690 · Publisher ↗

The treatment of patients diagnosed with schizophrenia exhibiting failing dentition with dental implant placement is understudied. Various factors play a role in treatment success, ranging from bone density to psychiatri... The treatment of patients diagnosed with schizophrenia exhibiting failing dentition with dental implant placement is understudied. Various factors play a role in treatment success, ranging from bone density to psychiatric symptoms, antipsychotic medication, or compromised oral hygiene. It is therefore imperative for a dental practitioner to recognize these factors and understand the clinical efficacy based on previous literature about placing implants in patients with schizophrenia. We reviewed existing literature on dental implant placement in individuals with schizophrenia, resulting in 3 positive cases of 4 total studies. Nondental implant placement was also reviewed, resulting in 2 positive outcomes of 6. It was concluded that if symptoms can be managed, as exhibited in the 2 positive dental implant case studies, individuals with schizophrenia can be good candidates for dental implantation.

Cross-Sectional Study on the Relationship Between Jawbone Types and Trabecular Bone Structures.

Liu H, Zhang Y, Yang Z … +4 more , Chen J, Han Q, Lv J, Zhang Z

J Oral Implantol · 2026 Jun · PMID 42242689 · Publisher ↗

This study investigated the relationship between jawbone types and trabecular bone structures. A total of 38 osseointegrated implants were placed in 33 partially edentulous patients (17 males and 16 females). The bone qu... This study investigated the relationship between jawbone types and trabecular bone structures. A total of 38 osseointegrated implants were placed in 33 partially edentulous patients (17 males and 16 females). The bone quality of the recipient sites was measured in Hounsfield units and classified according to the Norton and Gamble classification. Histomorphometric methods were employed to analyze the structure of trabecular bone, including bone volume fraction (BV/TV), trabecular thickness (Tb. Th), trabecular number, and trabecular separation. The mean values of the four variables in Type I were 52.66 ± 9.75%, 27.31 ± 12.73 µm, 22.77 ± 10.17/mm, and 24.01 ± 10.34 µm, respectively. The mean values for Types II/III were 37.92 ± 11.54%, 45.99 ± 26.71 µm, 11.58 ± 8.16/mm, and 82.39 ± 51.67 µm, respectively. The mean values for Type IV were 33.43 ± 10.32%, 20.27 ± 3.58 µm, 17.16 ± 6.42/mm, and 47.92 ± 29.11 µm, respectively. When comparing Type I with Type IV, BV/TV was the only variable that demonstrated a statistically significant difference (p < .001). In the comparison between Type I and Type II/III, all variables were statistically significant except for Tb. Th (p < .01). When comparing Type II/III with Type IV, Tb. Th was the only variable that showed a statistically significant difference (p < .01). It is crucial to select ideal implant sites before placement, considering the various bone types. Direct quantification of trabecular bone structure in a clinical setting is challenging; therefore, understanding bone types can aid in predicting implantation outcomes by assessing the relationship between bone type and trabecular bone structures.

Benign Paroxysmal Positional Vertigo in Oral Surgery and Implantology: A Review.

Gal EY, De Leon J, Romanos GE

J Oral Implantol · 2026 Jun · PMID 42242688 · Publisher ↗

Benign paroxysmal positional vertigo (BPPV) is a common inner ear disorder characterized by intense dizziness often triggered by sudden head movements. Certain dental and maxillofacial surgeries may induce BPPV due to vi... Benign paroxysmal positional vertigo (BPPV) is a common inner ear disorder characterized by intense dizziness often triggered by sudden head movements. Certain dental and maxillofacial surgeries may induce BPPV due to vibrational trauma from instrumentation, extended hyperflexion of the head, and existing vestibular conditions. This study aimed to analyze certain oral and maxillofacial surgical procedures associated with BPPV and evaluate prevention and treatment strategies. A review of relevant literature was conducted through Google Scholar and an extensive search on PubMed for the period 2005-2020 using the keywords "BPPV" and "benign paroxysmal positional vertigo." Articles were screened up to the 2564th listing, focusing on cases of postsurgical BPPV. Eight studies were included and analyzed, including case reports, retrospective analyses, and literature reviews. The procedures that led to BPPV in these studies include sinus floor elevation, maxillary implant placement, third molar extractions, and orthognathic surgery. Factors that contributed to the development of BPPV include surgical trauma, use of osteotomes, abnormal head positioning, and preexisting vestibular conditions. Although postoperative BPPV is typically self-limiting, treatment may involve physical rehabilitation (Epley maneuver) or pharmacotherapy (benzodiazepines, antihistamines). Analysis of the studies revealed that treatment considerations may include referral to an ear, nose, and throat practitioner for management; careful review of the patient's medical history; proper patient positioning; and cautious use of osteotomes. Although BPPV is a rare complication, surgeons should be aware of its potential implications to mitigate unnecessary development of BPPV and management of the condition. Further research is needed on the optimal prevention, treatment, and patient management strategies.

Guided Bone Regeneration and Connective Tissue Graft With Implant Placement in Critical Bone Defect Ridge: A 10-Year Case Report Follow-Up.

Rosa AJ, Machado AN, Mesquita HS … +7 more , Quinelato V, Crescencio LR, Lourenço ES, Alto RM, Ghiraldini B, Soares MAD, Casado PL

J Oral Implantol · 2026 Apr · PMID 41942138 · Publisher ↗

Implantology plays an important role in oral rehabilitation, but sometimes requires supplementary procedures to restore both functional and aesthetic parameters. The presence of alveolar bone and keratinized soft tissue... Implantology plays an important role in oral rehabilitation, but sometimes requires supplementary procedures to restore both functional and aesthetic parameters. The presence of alveolar bone and keratinized soft tissue is crucial for achieving an aesthetically pleasing result when installing an implant. However, the early loss of a tooth affects the anatomy of the remaining periodontal tissues, making it challenging to achieve the clinical results desired by both the patient and the professional. The rehabilitation of the dental arch with osseointegrated implants enables the improvement of patients' quality of life, complemented by the advent of guided bone regeneration (GBR), which provides an excellent alternative for reestablishing bone tissue, thereby allowing the implant to be fully integrated and maintained during functional loading. The evolution in the development of biomaterials and techniques related to GBR has revolutionized this therapeutic modality, thus facilitating the clinical resolution of cases with tissue deficiencies. This report presents a clinical case description outlining the methods, techniques, and materials of choice for the placement of a single implant, utilizing GBR with bovine xenogeneic bone graft and connective tissue graft via a tunneling technique. The execution of the planned procedures resulted in a satisfactory outcome for the patient. It returned functionality and aesthetics, demonstrating that they are effective alternatives capable of success in cases of bone resorption in critical areas. Guided bone regeneration improved peri-implant tissue maintenance, increasing prognosis during a 10-year follow-up.

Ovoid Emergence Profile Implant Restoration Design for Stabilization and Improvement of Peri-Implant Soft Tissue: Case Series and Technical Report.

Antonaya-Martín JL, Laguna-Martos M, Abad-Abad Á … +3 more , Rivas-Martín N, Fernández-Pascual M, Cascos R

J Oral Implantol · 2026 Apr · PMID 41942136 · Publisher ↗

This case series evaluated the peri-implant soft tissue improvement with an ovoid emergence profile implant restoration design on internal conical connection dental implants. An extrapolished zirconia monolithic 360° ovo... This case series evaluated the peri-implant soft tissue improvement with an ovoid emergence profile implant restoration design on internal conical connection dental implants. An extrapolished zirconia monolithic 360° ovoid design critical contour, like "lollipop," with a similar cement-enamel junction (CEJ) of replaced tooth, was used on an original titanium abutment, CAD/CAM abutment (TiBase), or multiunit abutment, with a minimum height of 3 mm and a concave design, to improve an optimal implant-supported restoration emergence profile that can stimulate peri-implant soft tissues due to the pressure and suction that generate a mechano-transduction response of soft tissue cells. Nine cases were rehabilitated using a full digital workflow and an ovoid emergence profile design, with follow-up at 6 months. A visual comparison was made between the placement photographs and the follow-up appointment photographs to assess the changes in peri-implant soft tissues over each period. In all cases, a visual soft tissue improvement can be appreciated, which seems to be an increase in soft tissue volume and the creation of new papillae. Within the limitations of this case series, it can be concluded that the ovoid emergence profile restoration design can improve peri-implant soft tissue without the need for temporary restorations or peri-implant mucogingival surgery.

Static Strength vs Clinical Reality: Caution in Extrapolating Conometric Advantages.

Ardila CM

J Oral Implantol · 2026 Apr · PMID 41942135 · Publisher ↗

Abstract loading — click title to view on PubMed.

The Regenerative Effects of Amnion-Chorion Membrane on Bone Marrow Derived Stem Cells.

Namli Kilic H, Hamada Y, Imamura K … +2 more , Batra C, Walker CL

J Oral Implantol · 2026 Apr · PMID 41942134 · Publisher ↗

The objective of this in vitro study was to evaluate the possible regenerative effects of dehydrated human amnion chorion membrane (ACM) on cell proliferation, migration, and differentiation/mineralization of bone marrow... The objective of this in vitro study was to evaluate the possible regenerative effects of dehydrated human amnion chorion membrane (ACM) on cell proliferation, migration, and differentiation/mineralization of bone marrow-derived stem cells (BMSCs). The dehydrated human ACM has been commonly used in periodontal regeneration and ridge augmentation procedures due to its membrane properties and growth factors. For the study, commercially available bone marrow-derived stem cells were thawed, cultured, and exposed to different concentrations of amnion-chorion membrane extract (50, 100, 200, 500, and 1000 μg/mL) in mesenchymal stem cell basal media. Cell proliferation was analyzed using the WST-1 assay, migration with the scratch-wound assay, and differentiation/mineralization with Alizarin Red S staining. Two-way ANOVA was used to assess the effects of concentration and time, with pair-wise comparisons made using Fisher protected least significant difference at a 5% significance level. Results showed that the control, 50 μg/mL, and 100 μg/mL groups exhibited lower cell proliferation compared with the 500 μg/mL and 1000 μg/mL groups. Lower concentrations also displayed reduced cell migration compared with the higher concentrations. In the mineralization assay, the control, 200 μg/mL, and 500 μg/mL groups exhibited lower cell mineralization compared with 1000 μg/mL. Temporally, shorter durations showed higher levels of cell migration and lower levels of cell mineralization. Overall, the use of amnion-chorion membrane positively affected cell proliferation, migration, and mineralization, with increased concentrations of amnion-chorion membrane extract yielding greater benefits. This study indicates that amnion-chorion membrane may enhance stem cell activities due to the presence of growth factors in the membrane. These findings are preliminary and must be interpreted cautiously. Further in vivo and clinical studies are necessary to validate these observations.

Particulate Bone Grafts vs Split Bone Cortical Plates: Resorbable and Nonresorbable Membranes in Vertical Augmentation.

Durrani F, Pandey A, M R … +3 more , Shilpi S, Agarwal S, Gawade M

J Oral Implantol · 2026 Apr · PMID 41942133 · Publisher ↗

This study aimed to evaluate vertical bone gain in the anterior edentulous mandible using the split cortical bone plate technique with 2 different graft and membrane combinations: autogenous particulate grafts with titan... This study aimed to evaluate vertical bone gain in the anterior edentulous mandible using the split cortical bone plate technique with 2 different graft and membrane combinations: autogenous particulate grafts with titanium-reinforced polytetrafluoroethylene membrane (T1) and a mixture of autogenous and xenograft particulate grafts with a collagen membrane (Bio-Gide) (T2). Twenty-two patients presenting with severe vertical alveolar ridge atrophy were randomly allocated into 2 equal groups with 11 participants in each group. Cone beam computerized tomography was used to assess vertical bone gain and crestal bone loss at 6 months, 1 year, and 5 years postgrafting. Keratinized tissue width and peri-implant probing depth were also measured at the same intervals to evaluate long-term soft tissue stability and peri-implant health. Whereas both groups demonstrated comparable vertical bone gain, the T1 group exhibited better maintenance of keratinized gingiva. It reduced crestal bone loss over time, suggesting the clinical utility of nonresorbable membranes in enhancing soft and hard tissue outcomes in complex augmentation cases.

Osseodensification in Different-Dimension Dental Implants: A Split-Mouth Clinical Study.

Zahoui A, Bergamo ETP, Coelho PG … +7 more , Benalcázar-Jalkh EB, Alves LMM, Alves Junior MAMA, Witek L, Bonjardim LR, Cheng YC, Bonfante EA

J Oral Implantol · 2026 Apr · PMID 41942132 · Publisher ↗

The purpose of this study was to compare the insertion torque (IT) and temporal implant stability quotients (ISQ) of different-dimension dental implants placed using subtractive drilling (SD) or osseodensification instru... The purpose of this study was to compare the insertion torque (IT) and temporal implant stability quotients (ISQ) of different-dimension dental implants placed using subtractive drilling (SD) or osseodensification instrumentation (OD). Twenty-three patients with edentulous spaces received at least 2 implants. Narrow or regular-diameter implants as well as short or regular-length implants were placed in the anterior or posterior maxilla. A split-mouth model was used with 105 implants placed. After osteotomies were performed following the manufacturer's recommendation, IT was recorded with a torque indicator, and ISQ with resonance frequency analysis was immediately performed after surgery and then weekly up to 6 weeks and at 10 weeks. IT data were analyzed using linear mixed models, whereas ISQ data were analyzed using repeated measures analysis of variance and Tukey tests. Multivariate regression models were used to assess correlations between changes in IT, ISQ, and covariates. The study included 11 females and 12 males (mean age 60.5 ± 14 years). Within the studied cohort, OD was associated with higher IT values than SD across the evaluated implant dimensions and sites. ISQ values were also higher in the OD group during the first 2 weeks. In multivariate regression, increased IT was correlated with implants placed in the anterior maxilla, regular diameter, and use of OD drilling. Whereas the investigated factors did not affect the baseline ISQ value, an increased ISQ during the early healing process was correlated with implants placed in the anterior maxilla and the use of an OD bur. Within the limitations of this study, OD demonstrated higher IT and early ISQ values compared with SD independent of implant dimension or surgical site. These findings suggest a potential impact of drilling technique on early implant stability within the study's parameters. Additional studies with larger and more diverse samples are needed to explore clinical relevance.

Tooth Transplantation and a Root Submergence Technique After Enucleation of Multiple Continuous Radicular Cysts for Implant Treatment: A Case Report.

Katayama N, Ueno D, Ishikawa T

J Oral Implantol · 2026 Apr · PMID 41942129 · Publisher ↗

When a radicular cyst-involved tooth is challenging to save, tooth extraction and cyst enucleation are required. Since only thin facial bone is present on the coronal side of cystic defects, bundle bone loss and continui... When a radicular cyst-involved tooth is challenging to save, tooth extraction and cyst enucleation are required. Since only thin facial bone is present on the coronal side of cystic defects, bundle bone loss and continuity of the cystic cavity after tooth extraction may result in extensive vertical bone defects. To prevent major bone augmentation, the following procedure was performed: the left maxillary incisor (#9), which exhibited apical lesions was extracted, while the right maxillary incisor (#8), despite having a healthy periodontal ligament but being difficult to save, was transplanted into the extraction socket of the left incisor (#9). After 5 months, the bone defect had completely regenerated without any resorption of the facial bone. The regenerated bone could be used for implant placement without exposure to the implant's rough surface. In addition, the alveolar bone and alveolar contour regenerated by the tooth transplantation showed no significant decrease even 2 years after the installation of the final prosthesis, and they maintained their esthetic condition. The results indicate that tooth transplantation with healthy periodontal tissue helps regenerate bone defects.

Gene Expression in Peri-Implant Bone with Severe Bone Loss: A Pilot Study Using Human Biopsies.

Malm MO, Jemt T, Trindade R … +1 more , Stenport VF

J Oral Implantol · 2026 Apr · PMID 41942127 · Publisher ↗

Peri-implant bone loss is a complication around osseointegrated dental implants. In severe cases, it can lead to implant loosening. The etiology and the process of bone loss are still not fully understood. No published s... Peri-implant bone loss is a complication around osseointegrated dental implants. In severe cases, it can lead to implant loosening. The etiology and the process of bone loss are still not fully understood. No published studies have analyzed cytokines in human peri-implant bone biopsies with severe bone loss. This study compares the expression of a selected panel of genetic markers from human bone biopsies and peri-implant crevicular fluid (PICF) surrounding dental implants with severe bone loss with biopsies from unaffected bone in the same patients. Nine patients planned for implant removal due to severe bone loss were included. The PICF samples were collected with paper points from the implant sites. From each patient, 1 sample of bone adjacent to the implant and 1 sample of unaffected bone were harvested. The samples were processed and analyzed with quantitative polymerase chain reaction. Expression of proinflammatory markers and markers for bone resorption and tissue degradation was upregulated in bone loss sites compared with unaffected bone. Although the results from PICF were similar, cautious interpretation is needed due to the pilot characteristics of the study. The results indicate that the immune system is active in inflammation and tissue degradation in the bone surrounding implants with severe bone loss. The gene expression findings from implant sites with severe bone loss reflected the clinical situation well-demonstrated by upregulated bone resorption markers and proinflammatory markers compared with unaffected bone. Further research is required to confirm these findings and explore the factors involved in severe bone loss around dental implants.

Implant Insertion in the Presence of Bone Islands in the Maxillary Sinus: A Case Report.

Xue J, Fang Q, Hu S … +1 more , Tao J

J Oral Implantol · 2026 Apr · PMID 41942126 · Publisher ↗

Bone islands in the maxillary sinus are rare, and no established guidelines exist for implant surgery in their presence. This case report presents an approach to implant surgery utilizing bone islands in the maxillary si... Bone islands in the maxillary sinus are rare, and no established guidelines exist for implant surgery in their presence. This case report presents an approach to implant surgery utilizing bone islands in the maxillary sinus. In this case, we utilized the bone island, performed osteotome sinus floor elevation combined with concentrated growth factor (CGF), and simultaneously inserted a Straumann Soft Tissue Level implant for a 56-year-old male patient. Based on 1-year follow-up examinations and cone beam computed tomography (CBCT) images, the approach yielded favorable outcomes. Utilizing bone islands in the maxillary sinus during implant surgery appears effective, but longer-term follow-up and additional cases are needed to validate this approach.

Comparison of the Mechanical Stability of Different Implant Types in the Atrophic Maxilla of Patients With Bruxism Using Finite Element Analysis.

Manav ÖC, Üçok C, Kocamaz ÖF

J Oral Implantol · 2026 Apr · PMID 41942123 · Publisher ↗

This study aims to evaluate the stress distribution in atrophic maxilla rehabilitation of bruxism patients using various implant types via finite element analysis (FEA). Four implant configurations were modeled: quad zyg... This study aims to evaluate the stress distribution in atrophic maxilla rehabilitation of bruxism patients using various implant types via finite element analysis (FEA). Four implant configurations were modeled: quad zygomatic, zygomatic with transnasal, zygomatic with pterygoid, and subperiosteal implants. A computed tomography-derived 3D anatomical model data was subjected to vertical (1000 N) and oblique (500 N) loading scenarios to simulate forces associated with bruxism. Cortical bone and implant stress values (Pmax, Pmin, and Von Mises) were analyzed. Results indicated that the subperiosteal model exhibited the lowest stress on surrounding bone, whereas the quad zygoma model showed the highest. Models integrating pterygoid or transnasal implants with zygomatic implants demonstrated more homogeneous force distribution and reduced peak stress compared to quad zygoma alone. Model 3 (zygoma + pterygoid) yielded the most balanced stress profile, suggesting reduced mechanical complications under bruxism conditions. Although all stress values remained below physiological thresholds, elevated levels under oblique forces imply heightened risk in bruxism patients. FEA results suggest that combining implant types can optimize load transmission and minimize biomechanical risks, especially in cases with severe maxillary atrophy. These findings support clinical decision-making in selecting implant configurations tailored for patients with parafunctional habits like bruxism.
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