Searches
/
European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes[JOURNAL]
European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes[JOURNAL]
Sun
200 papers
Two-Stage Fixation in a Rat Model of the Induced Membrane: A Novel Surgical Technique.
Pfister G, Venant J, Mathieu L … +2 more , Collombet JM, Durand M
Eur Surg Res · 2026 Jul · PMID 42397762 · Publisher ↗
Introduction In the context of high-energy trauma or ballistic injury, wound healing is often compromised by underlying structural damage such as bone loss, infection, or instability. The induced membrane technique (IMT)...
Introduction In the context of high-energy trauma or ballistic injury, wound healing is often compromised by underlying structural damage such as bone loss, infection, or instability. The induced membrane technique (IMT), a two-stage approach for segmental bone defects, is frequently used in the management of chronic infected wounds. Although a change in osteosynthesis is routinely performed between stages in clinical settings, no preclinical animal model has reproduced this key surgical step. We present a novel surgical technique in rats combining a reinforced polymethylmethacrylate (PMMA) spacer with a Kirschner wire during the first stage, followed by plate osteosynthesis during the second stage. This represents the first reported animal model of IMT that integrates a staged change in fixation. Methods Eleven Sprague Dawley rats underwent a 5-mm femoral bone defect creation stabilized with an intramedullary Kirschner wire and a PMMA spacer (stage one). Four weeks later, the spacer and wire were removed, and internal fixation was achieved using a locking plate system, after grafting the defect with cancellous bone (stage two). Clinical monitoring, radiographic imaging, and postmortem micro-CT analysis at 10 weeks post-second surgery assessed model feasibility and bone regeneration. All animals survived and maintained satisfactory weight and clinical status throughout the protocol. Conclusion This is the first reproducible animal model of IMT incorporating a staged change in osteosynthesis, closely mimicking clinical management of chronic bone wounds. The technique offers a robust preclinical platform for studying the influence of fixation methods on membrane properties and bone healing. It is particularly relevant for translational research in wound-associated bone defects and infection control.
Does treatment of jaundice matter before pancreaticoduodenectomy?: Results from an international multicentre Recurrence After Whipple (RAW) study.
Das B, Robb HD, Bobotis S … +6 more , Alghazawi LOK, Ashrafian H, Pai M, Fehervari M, Aroori S, Spalding D
Eur Surg Res · 2026 May · PMID 42160230 · Publisher ↗
OBJECTIVE: The management of jaundice before pancreaticoduodenectomy (PD) remains controversial. We aimed to analyse the clinical outcomes of jaundiced patients in a large cohort of PD patients stratified by treatment pa...
OBJECTIVE: The management of jaundice before pancreaticoduodenectomy (PD) remains controversial. We aimed to analyse the clinical outcomes of jaundiced patients in a large cohort of PD patients stratified by treatment pathway. METHODS: Data was collected from the Recurrence After Whipple's (RAW) study - an international, multicentre, retrospective cohort study of PD patients. Patients that underwent PD with subsequent histology confirmed pancreatic head ductal adenocarcinoma, ampullary adenocarcinoma, and distal cholangiocarcinoma were included in the RAW study. Patients were stratified into three groups by management of preoperative jaundice. RESULTS: Patients (n = 1,172) were classified into three groups: surgery while jaundiced (n = 109), surgery after successful preoperative biliary drainage (PBD) (n = 777) and not jaundiced (n = 286). Jaundice was an independent predictor of poor survival, whether treated (HR 1.45, CI 1.20-1.76) or untreated (HR 1.55, CI 1.16-2.09) pre-operatively. On multivariate analysis, PBD was associated with improved disease-free survival (HR 0.75, CI 0.58-0.97) but not overall survival (HR 0.93, CI 0.72-1.20) relative to the untreated jaundiced population. PBD was associated with a reduced, but statistically non-significant, risk of PD-related complications (OR 0.63 CI 0.39 - 1.02; p = 0.059). CONCLUSIONS: We observed a non-significant trend towards reduced perioperative complications and improved disease-free survival following PBD prior to PD.
The Application of Platysma Myocutaneous Flap in Tracheostomy after Total Laryngectomy: A Novel Surgical Technique.
Cao C, Wei F, Deng J … +2 more , Chai L, Wang Z
Eur Surg Res · 2026 · PMID 42030215 · Full text
INTRODUCTION: Here we presented a new surgical technique for tracheostomy using the platysma myocutaneous flap after total laryngectomy and analyzed its results and follow-up data. METHODS: In this innovative technique,...
INTRODUCTION: Here we presented a new surgical technique for tracheostomy using the platysma myocutaneous flap after total laryngectomy and analyzed its results and follow-up data. METHODS: In this innovative technique, longitudinal incisions are made on the posterior tracheal wall with a platysma myocutaneous flap for tracheostomy. The outcomes and analyses of 168 patients who underwent tracheostomy (from December 2006 to June 2021) were recorded. RESULTS: The incidence of post-tracheostomy tracheal stenosis was 2.38%, which is much lower than that of conventional surgery. Stoma size was not affected by body mass index, smoking, alcohol consumption, diabetes, and number of resected tracheal cartilage rings (p > 0.05). Patients who underwent this surgery had reduced psychological problems and increased physical appearance satisfaction. CONCLUSION: This technique is easily reproducible and suitable for patients with lower incidence of tracheal stenosis and higher satisfaction.
New Perfusion and Preservation Strategies for Donor Hearts.
Hettlich VH, Aubin H, Scherner M … +3 more , Ramadani B, Lichtenberg A, Boeken U
Eur Surg Res · 2026 · PMID 41973639 · Full text
BACKGROUND: Several systems for organ procurement and transportation are available in heart transplantation. Hypothermic storage of the cardioplegic heart has been the global standard since the 1980s and provides consist...
BACKGROUND: Several systems for organ procurement and transportation are available in heart transplantation. Hypothermic storage of the cardioplegic heart has been the global standard since the 1980s and provides consistently reliable outcomes. However, ischemic time remains limited to approximately 4-5 h. SUMMARY: Recent preservation strategies aim to extend ischemic tolerance. This has been demonstrated for both modified hypothermic systems (e.g., SherpaPak, VitalPack) and machine perfusion devices (e.g., OCS, XVIVO). Beyond clinical performance, system selection is strongly influenced by economic factors. While conventional hypothermic storage is fully reimbursed, the substantially higher costs of advanced systems are typically covered only within the framework of clinical studies or must be financed by transplant centers. KEY MESSAGES: Hypothermic storage remains the standard method with proven long-term reliability, but is limited by restricted ischemic time. Novel preservation technologies extend ischemic tolerance and may improve transplantation logistics; however, their widespread implementation is currently limited by high costs and restricted reimbursement.
Use of Human Amnion/Chorion Membrane as a Protective Barrier in Complicated Diverticulitis Patients Undergoing Colorectal Resections.
Das B, Choat D, Jrebi N … +1 more , Bardin M
Eur Surg Res · 2026 · PMID 41861042 · Full text
INTRODUCTION: Anastomotic leaks are a serious complication of colorectal surgery, particularly in patients undergoing colectomy for complicated diverticulitis. Dehydrated human amnion/chorion membrane (DHACM) allografts...
INTRODUCTION: Anastomotic leaks are a serious complication of colorectal surgery, particularly in patients undergoing colectomy for complicated diverticulitis. Dehydrated human amnion/chorion membrane (DHACM) allografts are FDA-regulated, non-viable cellular allografts derived from donated human placentas. This tissue is rich in cytokines and growth factors critical in wound healing and tissue growth. Animal models have demonstrated the benefits of these grafts for anastomotic healing in terms of increased bursting pressures, neoangiogenesis, fibroblast activity, collagenization, and epithelialization, as well as decreased inflammation. This study evaluated real-world outcomes associated with DHACM use as a protective barrier wrapped around the anastomotic site in patients undergoing colorectal resection for complicated diverticulitis. METHODS: This retrospective, multicenter study analyzed consecutive adult patients undergoing left-sided colectomy with primary colorectal anastomosis and DHACM application, between January 2016 and June 2024. Patients with uncomplicated diverticulitis or receiving protective stoma were excluded. The primary outcome was anastomotic leak incidence within 30 days of surgery. Secondary outcomes included reoperation, readmission, length of stay, and mortality. Outcomes were summarized descriptively. RESULTS: The study included 178 complicated diverticulitis patients with left-sided colectomy and no protective stoma. Three patients (1.7%) experienced an anastomotic leak, including two grade B leaks managed with antibiotics and one grade C leak requiring reoperation. The 30-day all-cause readmission rate was 3.9% (7/178), the median length of stay was 2 days and only 3 patients (1.7%) returned to surgery. CONCLUSIONS: In this real-world cohort of complicated diverticulitis patients undergoing colectomy, low rates of anastomotic leak, readmission, and reoperation were observed following application of DHACM around the anastomosis. These findings suggest DHACM may be a promising adjunct to support anastomotic healing in this high-risk population. Controlled prospective studies are warranted to confirm these observations.
Erratum.
Eur Surg Res · 2026 · PMID 41855300 · Full text
The article "Exploring an Alternative Preoperative Sentinel Lymph Node Mapping Method Using a Magnetic Tracer and Magnetic Resonance Imaging for Melanoma Patients: SCARLETT Study Protocol" [Eur Surg Res 2026;67:30-37; ht...
The article "Exploring an Alternative Preoperative Sentinel Lymph Node Mapping Method Using a Magnetic Tracer and Magnetic Resonance Imaging for Melanoma Patients: SCARLETT Study Protocol" [Eur Surg Res 2026;67:30-37; https://doi.org/10.1159/000549828] by Aldenhoven et al. was published with the wrong open access license. The correct license of the article is CC-BY.The original article has been updated.
Erratum.
Eur Surg Res · 2026 · PMID 41849631 · Full text
The article "Simultaneous Liver-Kidney Transplantation versus Liver Transplantation in End-Stage Liver Disease Patients with Kidney Dysfunction" [Eur Surg Res. 2026;67:46-55; https://doi.org/10.1159/000550008] by Bouari...
The article "Simultaneous Liver-Kidney Transplantation versus Liver Transplantation in End-Stage Liver Disease Patients with Kidney Dysfunction" [Eur Surg Res. 2026;67:46-55; https://doi.org/10.1159/000550008] by Bouari et al. was published with the wrong open access license. The correct license of the article is CC-BY.The original article has been updated.
Erratum.
Eur Surg Res · 2026 · PMID 41849620 · Full text
The article "Desensitization Strategies in Immunized Heart Transplant Recipients" [Eur Surg Res. 2026;67:1-9; https://doi.org/10.1159/000549669] by Goerler et al. was published with the wrong open access license. The cor...
The article "Desensitization Strategies in Immunized Heart Transplant Recipients" [Eur Surg Res. 2026;67:1-9; https://doi.org/10.1159/000549669] by Goerler et al. was published with the wrong open access license. The correct license of the article is CC-BY.The original article has been updated.
Retraction Statement.
Eur Surg Res · 2026 · PMID 41642743 · Full text
The authors' accepted manuscript "Is Methylene Blue a Reliable Substitute in Sentinel Lymph Node Biopsy? A Systematic Review across Oncologic Sites" [Eur Surg Res. 2025; https://doi.org/10.1159/000549037] by Saurabh Raj,...
The authors' accepted manuscript "Is Methylene Blue a Reliable Substitute in Sentinel Lymph Node Biopsy? A Systematic Review across Oncologic Sites" [Eur Surg Res. 2025; https://doi.org/10.1159/000549037] by Saurabh Raj, Rudrakshi Mahaldar, and Shahrukh Memon has been retracted by the Publisher and the Editor on the authors' behalf.After peer review, the accepted, unedited manuscript was published online as Early View. Before the final Version of Record was published, concerns were raised about the validity of references 4, 6, 7, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 40 and 41 of the manuscript.The corresponding author stated that errors arose due to their use of AI-assisted tools and requested that their manuscript be withdrawn from European Surgical Research. Consequently, the published author's accepted manuscript has been retracted.Saurabh Raj agrees to this retraction, Rudrakshi Mahaldar and Shahrukh Memon have not responded to our correspondence about this retraction.
Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.
Dere UA, Altintas F, Albuz B … +6 more , Çil N, Kuzucu P, Avci E, Senol H, Koluman A, Coskun ME
Eur Surg Res · 2026 · PMID 41474651 · Full text
INTRODUCTION: Wound healing is a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Despite promising results with platelet-rich plasma (PRP) and synthetic scaffolds used...
INTRODUCTION: Wound healing is a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Despite promising results with platelet-rich plasma (PRP) and synthetic scaffolds used separately, their combined in vivo effects remain insufficiently investigated. This experimental study presents the first results on a composite wound dressing integrating PRP, rich in growth factors, with electrospun polyvinyl alcohol (PVA) nanofibers, a biocompatible and stable polymer. METHODS: Full-thickness skin defects (1 × 1 cm2) were created in 21 adult female Sprague-Dawley rats and divided into three groups: control, PVA, and PRP/PVA. Wound healing was assessed histologically and biochemically on days 7 and 14, including fibroblast growth factor-2 (FGF-2) measurement. RESULTS: The PRP/PVA group showed enhanced epithelialization and angiogenesis compared to other groups (p < 0.05), along with higher FGF-2 levels. CONCLUSION: The relatively small sample size, absence of a PRP-only group, and short observation period limit the generalizability of these findings. Within these constraints, the results indicate a potential synergistic role of PRP and PVA scaffolds in promoting wound repair, supporting further studies with larger cohorts and standardized PRP preparation before clinical translation.
Exploring the Impact of an Artificial Intelligence-Based Intraoperative Image Navigation System in Laparoscopic Surgery on Clinical Outcomes: A Protocol for a Multicenter Randomized Controlled Trial.
Kitaguchi D, Fuse N, Wakabayashi M … +6 more , Kosugi N, Ishikawa Y, Hayashi K, Hasegawa H, Takeshita N, Ito M
Eur Surg Res · 2026 · PMID 41452791 · Full text
INTRODUCTION: Artificial intelligence (AI), particularly deep learning-based computer vision technology, has been used in surgery as real-time intraoperative navigation; however, its clinical relevance remains unclear. T...
INTRODUCTION: Artificial intelligence (AI), particularly deep learning-based computer vision technology, has been used in surgery as real-time intraoperative navigation; however, its clinical relevance remains unclear. To address this gap, well-designed randomized controlled trials (RCTs) are necessary to evaluate the effects of these systems by comparing surgical outcomes with and without their use. In this study, we will investigate a deep learning-based intraoperative image navigation system that operates in real time and uses semantic segmentation to help identify the ureter and autonomic nerves during laparoscopic colorectal surgery. We propose a multicenter RCT to compare the procedure of using this system against those that do not. METHODS: The ImNavi trial is a Japanese multicenter RCT involving 1:1 randomization between the use and nonuse of the deep learning-based intraoperative image navigation system. The participating institutions will include three high-volume centers with sufficient laparoscopic colorectal surgery caseloads (>100 cases/year), including one national cancer center and two university hospitals in Japan. All patients will provide written informed consent. Patients aged between 18 and 80 years scheduled to undergo laparoscopic left-sided colorectal resection will be included in the study. The primary outcome is the time required for each target organ, including the ureter and autonomic nerves, to be recognized by the surgeon after its initial appearance on the monitor. Secondary outcomes include intraoperative target organ injuries, intraoperative complications, operation time, blood loss, duration of postoperative hospital stay, postoperative complications within 30 days, postoperative male erectile and ejaculatory dysfunction 1 month post surgery, surgeon's confidence in recognizing each target organ, and the postoperative fatigue of the primary surgeon. CONCLUSION: The impact of AI-based surgical applications on clinical outcomes beyond numerical expression will be explored from diverse viewpoints while evaluating quantitative items, including intraoperative complications and operation time, as secondary endpoints. The findings of this RCT can contribute to advancing research in the domain of AI in surgery.
Brachial Plexus Blockage versus General Anesthesia for Upper Extremity Surgery: A Systematic Review and Meta-Analysis.
Llombart-Blanco R, Benlloch M, Mariscal G … +5 more , Vera P, Polevoi E, Dway A, Barrios C, Llombart-Ais R
Eur Surg Res · 2026 · PMID 41428588 · Full text
INTRODUCTION: This meta-analysis investigated differences in rebound pain and opioid consumption when using brachial plexus blockade (BPB) versus general anesthesia (GA) for upper limb surgery. METHODS: Four databases we...
INTRODUCTION: This meta-analysis investigated differences in rebound pain and opioid consumption when using brachial plexus blockade (BPB) versus general anesthesia (GA) for upper limb surgery. METHODS: Four databases were searched. Odds ratios (OR), mean differences (MD), and standard mean differences (SMD) with 95% confidence intervals (CIs) were calculated. Outcomes included were pain, opioid consumption, adverse events, and discharge time. The risk of bias was assessed. RESULTS: Nine clinical trials involving 487 patients were included. BPB resulted in significantly lower pain scores within 2 h postoperatively (MD -4.57, 95% CI -5.76 to 3.38; participants = 263; studies = 5; I2 = 0%; p < 0.00001) but not from 6 to 24 h. Opioid consumption (mg) was lower in the BPB group in the first 24 h (SMD -0.85, 95% CI -1.41 to -0.29; participants = 188; studies = 3; I2 = 67%; p < 0.003). BPB was associated with fewer postoperative nausea/vomiting events (OR 0.19, 95% CI 0.10-0.33; participants = 326; studies = 6; I2 = 45%; p < 0.00001) and shorter hospital stay (SMD -1.20, 95% CI -1.73 to -0.66; participants = 213; studies = 4; I2 = 69%; p < 0.0001). There was no difference in the number of patients not requiring opioids from 24 to 48 h. CONCLUSIONS: BPB provided superior pain control at 2 h postoperatively and was associated with reduced opioid use, fewer adverse events, and shorter discharge time. No significant differences in pain scores were observed at 6-24 h or beyond 24 h, likely due to block wear-off. Despite this limitation, BPB still offered perioperative advantages over GA.
Retraction Statement.
Eur Surg Res · 2025 · PMID 41406051 · Publisher ↗
Abstract loading — click title to view on PubMed.
Simultaneous Liver-Kidney Transplantation versus Liver Transplantation in End-Stage Liver Disease Patients with Kidney Dysfunction.
Bouari S, Fang Y, van de Wetering J … +13 more , de Meijer VE, Pol RA, Berger SP, Polak WG, Blokzijl H, de Vries APJ, Coenraad MJ, Lam HD, de Vries DK, Porte RJ, den Hoed CM, IJzermans JNM, Minnee RC
Eur Surg Res · 2026 · PMID 41396967 · Full text
INTRODUCTION: The role of simultaneous liver-kidney transplantation (SLKT) in end-stage liver disease patients with varying kidney dysfunction remains unclear. This study aims to compare clinical outcomes of SLKT recipie...
INTRODUCTION: The role of simultaneous liver-kidney transplantation (SLKT) in end-stage liver disease patients with varying kidney dysfunction remains unclear. This study aims to compare clinical outcomes of SLKT recipients with those undergoing liver transplant alone (LTA) with comparable kidney dysfunction. METHODS: This retrospective cohort study included the SLKT cohort (n = 52) from the Dutch Organ Transplantation Registration and the LTA cohort (n = 829) from Erasmus Medical Center between 2000 and 2020. Patients were stratified by pretransplant renal function (chronic kidney disease [CKD] stages 3b-5) and pretransplant renal replacement therapy (RRT) status. Patient and graft survival, and renal function were compared across renal function strata. RESULTS: Across CKD stages 3b and 4, there was no statistically significant difference in overall survival rates (p = 0.59 and p = 0.23, respectively). For patients with CKD stage 5 or RRT, patient survival rates at 1, 3, and 5 years posttransplant were significantly lower in the LTA group (60.3%, 51.7%, and 51.7%, respectively) compared to the SLKT group (90.0%, 90.0%, and 80.8%, p = 0.048). Death-censored liver graft survival rates at 1, 3, and 5 years were also significantly lower in the LTA group (59.8%, 49.9%, and 49.9%) versus SLKT group (86.4%, 86.4%, and 77.0%, p = 0.048). Cox proportional hazards model confirmed the association between SLKT and improved patient survival (HR 0.31, 95% CI: 0.10-0.98, p = 0.046). CONCLUSION: For patients with CKD stage 5 or those on pretransplant RRT, SLKT was associated with better survival outcomes compared to LTA. Primary etiology of liver disease and severity of kidney dysfunction should be considered when determining SLKT eligibility. Due to the limited group size, these findings should be interpreted with caution and further validated.
Immunotherapy for Solid Tumours: Current Clinical Landscape and Future Directions.
van Diepen AE, Kucukcelebi S, de Vos-Geelen J … +1 more , Kooreman NG
Eur Surg Res · 2026 · PMID 41379722 · Full text
BACKGROUND: Cancer immunotherapy has transformed the therapeutic landscape of oncology by harnessing the body's immune system to recognise and eliminate malignant cells. In certain tumour types, such as melanoma and non-...
BACKGROUND: Cancer immunotherapy has transformed the therapeutic landscape of oncology by harnessing the body's immune system to recognise and eliminate malignant cells. In certain tumour types, such as melanoma and non-small cell lung cancer, immune-based therapies have led to durable clinical responses and significantly improved survival. These successes have fuelled the rapid integration of immunotherapeutic approaches into standard treatment regimens. However, their effectiveness in the majority of solid tumours remains limited. Several biological and physical barriers underlie this limited efficacy. A major challenge is the immunosuppressive nature of the tumour microenvironment (TME), which hampers effective immune cell infiltration and function. In many solid tumours, chronic inflammation, poor antigen presentation, a low mutational burden, and the presence of suppressive myeloid and stromal cells create an environment resistant to immune activation. In addition, high intra-tumoral pressure and abnormal vasculature further restrict drug delivery and immune cell trafficking, particularly in desmoplastic cancers such as pancreatic and prostate cancer. SUMMARY: Recent advances in immuno-oncology have focused on strategies to overcome these barriers and convert "cold" tumours, those lacking immune cell infiltration, into "hot," immune-inflamed tumours. Despite this progress, clinical translation has proven to be complex, with mixed results across various tumour types. While some patients derive long-term benefit from immunotherapy, others exhibit primary or acquired resistance, underscoring the need for better patient stratification and predictive biomarkers. KEY MESSAGES: This review provides a comprehensive overview of the evolving field of immunotherapy for solid tumours, discussing key mechanisms of immune resistance, the role of the TME, and the multifactorial nature of therapeutic failure. It highlights the importance of understanding tumour-immune interactions in their full biological context, and explores current thinking on how to reshape the immune landscape of solid tumours. By addressing both immunological and physical barriers, future approaches may broaden the benefit of immunotherapy beyond its current scope, ultimately improving outcomes for patients with traditionally treatment-resistant cancers.
Predictive Factors for Infectious Complications after Robotic Gastrectomy for Gastric or Esophagogastric Junction Cancer.
Kaida S, Takebayashi K, Otake R … +7 more , Fukuo A, Nitta N, Mori H, Maehira H, Kojima M, Miyake T, Tani M
Eur Surg Res · 2026 · PMID 41363673 · Full text
INTRODUCTION: Robotic gastrectomy offers perioperative advantages such as reduced blood loss and faster recovery; however, infectious complications remain a significant concern. In this study, we aimed to identify the pr...
INTRODUCTION: Robotic gastrectomy offers perioperative advantages such as reduced blood loss and faster recovery; however, infectious complications remain a significant concern. In this study, we aimed to identify the predictive factors for postoperative infectious complications following radical robotic gastrectomy in patients with gastric or esophagogastric junctional cancer. METHODS: This retrospective single-center study analyzed data from 155 patients with gastric or esophagogastric junction cancer who underwent curative robotic gastrectomy between December 2017 and April 2025 to identify predictive factors for postoperative infectious complications. Twenty-two variables, including nutritional indices and surgical factors, were evaluated. RESULTS: A total of 18 patients developed Clavien-Dindo grade II-IIIa infectious complications. Infectious complications included pneumonia (n = 5, 3.2%), intra-abdominal abscess (n = 5, 3.2%), anastomotic leakage (n = 3, 1.9%), cholecystitis (n = 2, 1.2%), nonocclusive mesenteric ischemia (n = 1, 0.6%), bile leakage (n = 1, 0.6%), and sepsis (n = 1, 0.6%). The number of patients with complications and American Society of Anesthesiologists Physical Status (ASA-PS) class ≥3 (p = 0.006) and preoperative smoking (p = 0.012) was higher than that among patients without complications. Although hemoglobin levels (p = 0.041) and lymphocyte-to-monocyte ratios (p = 0.017) were lower in patients with complications, the platelet-to-lymphocyte ratios (p = 0.034) were higher. Multivariate analysis revealed that current smoking (odds ratio, 3.21; 95% confidence interval, 1.24-18.21) and ASA-PS class of ≥3 (odds ratio, 3.8; 95% confidence interval, 1.18-7.52) were identified as predictors of infectious complications. CONCLUSION: Robotic gastrectomy offers technical advantages, but optimizing patient-specific risk is essential for the best outcomes. Preoperative smoking and a high ASA-PS class were independent predictors of infectious complications following robotic gastrectomy. Enhanced perioperative management targeting these risk factors may reduce postoperative morbidity.
Desensitization Strategies in Immunized Heart Transplant Recipients.
Goerler A, Kruszona S, Aburahma K … +6 more , de Manna ND, Salman J, Ruhparwar A, Avsar M, Schmack B, Ius F
Eur Surg Res · 2026 · PMID 41363670 · Full text
BACKGROUND: Allosensitization, defined as the presence of anti-HLA antibodies before transplantation, prolongs the waiting list time and increases the waiting list mortality in patients awaiting heart transplantation. Tr...
BACKGROUND: Allosensitization, defined as the presence of anti-HLA antibodies before transplantation, prolongs the waiting list time and increases the waiting list mortality in patients awaiting heart transplantation. Treatment protocols have been developed to reduce the load of preformed anti-HLA antibodies (pfDSAs), defined as desensitization, and allow safe transplantation across the anti-HLA antibody barrier. Aim of this review was to give an overview on the actual desensitization strategies in heart transplantation. SUMMARY: Desensitization can be performed before transplantation or at the time of transplantation when a donor offer becomes available. Treatment protocols should include drugs and interventions that clear pfDSA, target antibody production, and mitigate antibody-mediated graft damage. By now, several transplant centers have developed their own protocols, with optimal graft survival, freedom from antibody-mediated rejection and from coronary allograft vasculopathy, without any significant adverse events. The evolution of the immunoassays for pfDSA detection has allowed a better precision in pfDSA characterization, such as measurement of titer and complement-binding capacity. These refinements have permitted crossing acceptable pfDSA without any need of desensitization. KEY MESSAGES: Crossing the HLA barrier is feasible and safe in heart transplantation. The complexity and redundancy of the immune pathways requires the identification of the appropriate therapy for each patient. Desensitization protocols should include more than one drug and intervention.
Exploring an Alternative Preoperative Sentinel Lymph Node Mapping Method Using a Magnetic Tracer and Magnetic Resonance Imaging for Melanoma Patients: SCARLETT Study Protocol.
Aldenhoven L, Frotscher C, Körver-Steeman R … +10 more , Martens MH, Spiekerman van Weezelenburg MA, van Kuijk SMJ, Kuburic D, Janssen A, Vissers YLJ, van Haaren ERM, Quaedvlieg P, Beets GL, van Bastelaar J
Eur Surg Res · 2026 · PMID 41363668 · Full text
INTRODUCTION: Sentinel lymph node biopsy (SLNB) plays a critical role in the clinical management of malignant melanoma. The current standard of care involves the preoperative injection of a Technetium-labeled (99mTc) col...
INTRODUCTION: Sentinel lymph node biopsy (SLNB) plays a critical role in the clinical management of malignant melanoma. The current standard of care involves the preoperative injection of a Technetium-labeled (99mTc) colloidal nanomaterial to facilitate lymphatic mapping. During surgery, patent blue (PB) is administered to enhance visualization of the lymphatic pathways. However, this dual-tracer approach presents notable drawbacks, including patient exposure to ionizing radiation and logistical challenges stemming from the short half-life of (99mTc). Superparamagnetic iron oxide nanoparticles (SPIO) have emerged as a nonradioactive alternative. Used in conjunction with a handheld magnetometer system (Magtrace® and Sentimag®, Endomagnetics Ltd.), SPIO enables SLN detection without the need for nuclear medicine infrastructure. In clinical studies involving breast cancer patients, SPIO has demonstrated non-inferiority to the conventional 99mTc and PB protocol. Given these findings, SPIO is hypothesized to offer equivalent performance in melanoma patients. This study is designed to evaluate the non-inferiority of preoperative magnetic resonance imaging (MRI) using SPIO compared to traditional lymphoscintigraphy and single-photon emission computed tomography/computed tomography with 99mTc for SLN identification in melanoma. Additionally, the study assesses the non-inferiority of intraoperative SLNB using SPIO and the Sentimag® device relative to the current gold standard based on 99mTc. METHODS: A prospective, single-arm, non-inferiority study will be conducted at the Department of Surgical Oncology, Zuyderland Medical Center, Sittard, the Netherlands. The study will enroll 140 adult patients diagnosed with stage I-II primary melanoma who are scheduled to undergo wide local excision and SLNB. All participants will undergo lymphatic mapping using both Magtrace® and 99mTc. The MRI protocol, previously evaluated in a pilot study, was demonstrated to be feasible. Implementation of the MRI protocol will proceed if non-inferiority is established within a predefined margin of 5%. CONCLUSION: Elimination of radiation exposure is beneficial for both patients and healthcare personnel. Moreover, logistic challenges will be eliminated as SPIO can be injected several days before surgery, immediately followed by MRI scanning. Scheduled surgeries will not be jeopardized by preoperative logistics and procedures. It will increase hospital-oriented productivity, patient-friendliness and comfort as surgical delays are avoided.
Is Methylene Blue a Reliable Substitute in Sentinel Lymph Node Biopsy? A Systematic Review Across Oncologic Sites.
Raj S, Mahaldar R, Memon S
Eur Surg Res · 2025 Nov · PMID 41199536 · Publisher ↗
BACKGROUND: Sentinel lymph node biopsy (SLNB) is a pivotal technique for evaluating regional lymphatic spread in breast, melanoma, and gynecologic malignancies. It minimizes surgical morbidity by avoiding complete lympha...
BACKGROUND: Sentinel lymph node biopsy (SLNB) is a pivotal technique for evaluating regional lymphatic spread in breast, melanoma, and gynecologic malignancies. It minimizes surgical morbidity by avoiding complete lymphadenectomy in early-stage disease. The standard dual-tracer approach-combining a radiocolloid such as technetium-99m with a blue dye like patent blue or isosulfan blue-has high sensitivity but is not universally accessible. Radiocolloids require nuclear medicine facilities' licensing and pose logistical burdens, while patent blue may provoke allergic reactions, including anaphylaxis. These limitations are particularly pronounced in low- and middle-income countries (LMICs), where access and affordability are ongoing challenges. Methylene blue (MB), a low-cost, widely available dye, has gained traction as an alternative tracer, offering a safer and more feasible option for SLNB in resource-limited settings. OBJECTIVE: This systematic review evaluates the diagnostic accuracy, detection reliability, and safety profile of methylene blue dye in SLNB across diverse oncologic sites, emphasizing comparing outcomes with traditional dual-tracer approaches. METHODS: A systematic review of PubMed, Embase, Scopus, and Cochrane Library was conducted for studies published from 2000 to 2025. Inclusion criteria comprised clinical studies utilizing MB for SLNB in breast, melanoma, gynaecological, or other solid tumours, reporting outcomes such as detection rate, false-negative rate, or tracer-related complications. Data were extracted and synthesized descriptively. Where possible, pooled performance metrics were calculated. RESULTS: Twenty-five studies encompassing 5,240 patients were included. The pooled sentinel node detection rate using MB alone was 84.5% (72.0-96.2%), with a false-negative rate of 8.6%. When MB was combined with radiocolloid, detection rates improved to 96.1%, and false-negative rates dropped below 5%. Adverse effects were rare, with skin necrosis in fewer than 2% of cases and no serious allergic events reported. Most studies focused on breast cancer (18/25), while data on melanoma and gynecologic cancers were comparatively limited. CONCLUSION: Methylene blue is a viable alternative for SLNB, particularly in environments where dual-tracer methods are impractical. Though slightly less sensitive than dual-tracer techniques, MB offers substantial advantages in cost, safety, and accessibility. Further multicenter studies and long-term outcomes are needed to support its broader adoption in global oncology practice.
Outcomes of En Bloc Kidney Transplants from Small Deceased Pediatric Donors to Adult Recipients: A Single-Center Experience.
Yan H, Kal-van Gestel J, Fang Y … +4 more , van de Wetering J, Kimenai HJAN, de Bruin RWF, Minnee RC
Eur Surg Res · 2025 Sep · PMID 40999819 · Publisher ↗
Introduction The shortage of donor grafts for kidney transplantation remains a critical challenge. En bloc kidney transplantation (EBKT) from small deceased pediatric donors can potentially expand the donor pool. This st...
Introduction The shortage of donor grafts for kidney transplantation remains a critical challenge. En bloc kidney transplantation (EBKT) from small deceased pediatric donors can potentially expand the donor pool. This study aimed to investigate the safety of pediatric-donor EBKT in adults compared with the standard deceased kidney transplantation (SDKT). Methods This retrospective study was performed to compare outcomes after pediatric-donor EBKT (n = 17; donor weight, 9.8 4.0 kg) and SDKT (n = 72; donor weight, 79.6 18.4 kg) in adult recipients at our center. Outcomes of EBKT from donors weighing 10 kg were compared with those from donors weighing ≥10 kg. The primary outcome was death-censored graft survival. Secondary outcomes included patient survival, serum creatinine, and the incidence of postoperative complications. Results The death-censored graft survival rates at 1, 5, and 10 years were 0.86 ± 0.09, 0.86 ± 0.09, and 0.86 ± 0.09, respectively, for pediatric-donor EBKTs, and 0.84 ± 0.05, 0.76 ± 0.07, and 0.64 ± 0.13, respectively, for SDKTs (P > 0.05). The patient survival rates at 1, 5, and 10 years were 0.93 ± 0.06, 0.67 ± 0.16, and 0.24 ± 0.20, respectively, for pediatric-donor EBKTs, and 0.86 ± 0.04, 0.60 ± 0.08, and 0.42 ± 0.10, respectively, for SDKTs (P > 0.05). No significant differences were observed between pediatric-donor EBKT and SDKT groups in postoperative complications (P > 0.05). Subgroup analysis of pediatric-donor EBKT by donor body weight revealed no significant differences (P > 0.05) in long-term graft and patient survival. Conclusion Pediatric-donor EBKT in adults is a safe approach, with outcomes comparable to those of SDKT in our study. Moreover, EBKT from donors weighing <10 kg demonstrated comparable long-term graft and patient survival to that from donors weighing ≥10 kg. Considering the small sample size and the increased mortality observed over time, further research involving larger cohorts is necessary to validate these findings and to refine criteria for optimal recipient selection.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe