Nayak M, Prabhu SS, Sreedhar D
… +3 more, Muragundi PM, Janodia MD, Ligade VS
J Cutan Aesthet Surg
· 2025 · PMID 40212433
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OBJECTIVES: Cosmetics have become a part of the daily grooming routine. The majority of women utilize cosmetics to some extent without much knowledge about their side effects. Adverse reactions can occur immediately afte...OBJECTIVES: Cosmetics have become a part of the daily grooming routine. The majority of women utilize cosmetics to some extent without much knowledge about their side effects. Adverse reactions can occur immediately after the application of the product or during their long-term usage. Adverse reactions related to cosmetics go unnoticed and under-reported. Women are most likely affected by adverse reactions compared with men. This study aimed to analyze the awareness level among Indian women regarding adverse reactions caused by cosmetic products. MATERIAL AND METHODS: A cross-sectional study was performed among South Indian women from March 2021 to July 2022. A sample of 400 each, working women (WW) and nonworking women (NW), was selected using the snowball technique, and data were collected using a self-administered questionnaire through Google Forms. Data were analyzed by using Statistical Package for Social Sciences (SPSS) version 21 and descriptive statistics were applied. RESULTS: In total, 791 (98.8%) participants used various cosmetic products. A total of 163 (41.1%) WW and 139 (35.1%) NW experienced adverse effects due to the use of cosmetic products. Skincare products cause more adverse reactions compared with other cosmetic products. The primarily affected body site was the face. The majority of respondents solved their adverse reactions problem by adopting self- medication. CONCLUSION: A significant percentage of the respondents experienced adverse side effects due to the usage of cosmetics. Awareness regarding the possibility of cosmetic-induced adverse effects, as well as the proper use of cosmetics to reduce these adverse effects is imperative. Implementation and appropriate application of cosmetovigilance can aid in limiting or eliminating the presence of dangerous substances in cosmetics and also helps in decreasing adverse events.
J Cutan Aesthet Surg
· 2025 · PMID 40212431
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OBJECTIVES: Numerous studies have been conducted on the clinical efficacy of immunotherapeutic agents in the treatment of cutaneous warts showing variable results. The present study aimed to compare the clinical efficacy...OBJECTIVES: Numerous studies have been conducted on the clinical efficacy of immunotherapeutic agents in the treatment of cutaneous warts showing variable results. The present study aimed to compare the clinical efficacy and safety of intralesional tuberculin purified protein derivative (PPD) and Vitamin D therapy in recurrent and recalcitrant extra-genital cutaneous warts. MATERIAL AND METHODS: This study was conducted as a prospective, randomized, comparative, and single-blind study. A total of 104 patients were randomly distributed into two treatment groups: Group A (Tuberculin PPD, = 53) and Group B (Vitamin D, = 51). Each patient in Group A received an intralesional injection of 0.1 mL tuberculin PPD (5 Tuberculin Units), while each patient in Group B received an intralesional injection of 0.2 mL Vitamin D (Cholecalciferol containing 120,000 IU). The injections were given at the initial visit (week 0) and after every 2 weeks for a maximum of four sessions (weeks 2, 4, and 6). The largest wart was selected for intralesional therapy. The categorization of clinical response was done based on the percent reduction in the size of warts into complete (appearance of normal skin), marked (>50% reduction), moderate (<50% reduction), and inadequate (no change in warts) responses. Adverse effects (if any) were recorded during each patient visit. The final response was evaluated at 6 months follow-up from the last treatment session. RESULTS: Regarding the response of patients to tuberculin PPD therapy, out of a total of 53 patients, 40 (75.5%) showed a complete response. Regarding the response of patients to Vitamin D therapy, out of a total of 51 patients, 36 (70.6%) showed a complete response. However, the difference in the response to the treatment between the two groups was statistically insignificant ( = 0.402). CONCLUSION: Both intralesional tuberculin PPD and Vitamin D are effective and safe in the treatment of all recurrent and recalcitrant extra-genital cutaneous warts.
Singh Y, Rajamohanan RR, Vasudevan S
… +1 more, Kuruvila S
J Cutan Aesthet Surg
· 2025 · PMID 40212430
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OBJECTIVES: The objective of this study was to determine the effectiveness of intralesional injection of bleomycin in the management of difficult-to-treat and resistant cutaneous warts. MATERIAL AND METHODS: A total of 5...OBJECTIVES: The objective of this study was to determine the effectiveness of intralesional injection of bleomycin in the management of difficult-to-treat and resistant cutaneous warts. MATERIAL AND METHODS: A total of 54 patients were enrolled in the study, of whom 52 completed it. We administered 0.1% bleomycin over the warts and conducted follow-up at 4, 8, and 12 weeks. If the warts were not completely clear, we administered the next dose of intralesional bleomycin at each visit until the third visit. If the lesions resolved at the third visit, we conducted a telephonic interview for the next follow-up at the end of 12 weeks to record any recurrence of warts and residual side effects. RESULTS: Out of 54 patients enrolled in the study, two were lost to follow-up. About 49 (94.2%) patients had clearance of warts at the end of the study period. About 45 (86.5%) patients had complete resolution of lesions after the first session. Three patients achieved complete clearance after the second treatment session. One patient achieved complete clearance at the end of the 12 week. One patient showed a partial response at the end of the 12-week treatment. There was no response for two patients at the end of 12 weeks. Two patients were lost to follow-up. CONCLUSION: The present study demonstrates that intralesional bleomycin is an efficient and safe treatment option in the management of resistant and difficult-to-treat warts.
J Cutan Aesthet Surg
· 2025 · PMID 40212429
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Metastatic or cutaneous Crohn's disease (MCD) is a rare manifestation of Crohn's disease and presents with ulcers, nodules, edema, fissures, and fistula. The genital involvement is seen in almost 50% patients and linear...Metastatic or cutaneous Crohn's disease (MCD) is a rare manifestation of Crohn's disease and presents with ulcers, nodules, edema, fissures, and fistula. The genital involvement is seen in almost 50% patients and linear ulcers (knife-cut ulcers) are characteristic clinical features. The histopathological findings of skin lesions are similar to gastrointestinal involvement and are diagnostic. The treatment options for the management of MCD include topical and oral steroids, oral metronidazole, as well as immunosuppressants such as methotrexate, azathioprine, cyclosporine, and tumor necrosis factor alpha inhibitors. We present three cases of MCD who were treated with platelet-rich fibrin therapy as adjuvant and resulted in rapid healing of ulcers.
J Cutan Aesthet Surg
· 2025 · PMID 40212428
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Bicalutamide is a non-steroidal androgen receptor antagonist that exerts anti-androgenic effects on peripheral tissues. It has been recently of interest in female pattern hair loss and has led to the off-label use of thi...Bicalutamide is a non-steroidal androgen receptor antagonist that exerts anti-androgenic effects on peripheral tissues. It has been recently of interest in female pattern hair loss and has led to the off-label use of this drug for the improvement of Sinclair grading in such patients. This review aims to discuss the pharmacological properties along with indications, contraindications, and safety profile of bicalutamide for its use in dermatological research.
Asher CM, Oluboyede D, Mario AI
… +1 more, Malata CM
J Cutan Aesthet Surg
· 2025 · PMID 40212427
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Forehead defects pose a reconstructive challenge and multiple revisions are often required to achieve satisfactory outcomes. The case history of a 20-year-old woman undergoing radical resection of a forehead malformatio...Forehead defects pose a reconstructive challenge and multiple revisions are often required to achieve satisfactory outcomes. The case history of a 20-year-old woman undergoing radical resection of a forehead malformation and reconstruction with an anterolateral (ALT) free flap is described. Although free tissue transfer with an ALT was successful, its color and texture mismatch were unacceptable to the patient. The esthetic result and patient satisfaction were improved by subsequent tissue expansion of the contralateral forehead, removal of the free flap and advancement of the contralateral forehead skin. Complex reconstructions utilize a breadth of techniques. We illustrate a dynamic use of the reconstructive ladder, implementing a descending approach to achieve a satisfactory reconstruction objectively and subjectively from the patient perspective.
J Cutan Aesthet Surg
· 2025 · PMID 40212426
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Earlobe keloids are a common condition with varied and cross-specialty presentation. The condition is often recalcitrant and difficult to treat on account of its location. Frequent recurrences following excision is often...Earlobe keloids are a common condition with varied and cross-specialty presentation. The condition is often recalcitrant and difficult to treat on account of its location. Frequent recurrences following excision is often frustrating for the patient and the surgeon. Application of pressure along with intra operative and postoperative intralesional steroids is a popular choice and is in vogue by surgeons and dermatologists. However, considering the uniqueness of the structure for every individual, it is often difficult to ensure one size fits all when using pressure therapy as an adjunct. We designed a simple polymethyl methacrylate (PMMA) dental prosthesis to ensure comfortable yet effective constant pressure over the lesion to ensure complete aesthetic outcome without recurrence in an operated earlobe keloid.
Litaiem N, Fazzani M, Ben Kahla M
… +6 more, Aounallah A, Bel Hadj Mabrouk E, Kandara H, Ennayfer R, Boukhris I, Zeglaoui F
J Cutan Aesthet Surg
· 2025 · PMID 40212425
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OBJECTIVES: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicles. Guidelines for the management of HS in North Africa are lacking. We aimed to develop the Tunisian consensus for the manag...OBJECTIVES: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicles. Guidelines for the management of HS in North Africa are lacking. We aimed to develop the Tunisian consensus for the management of HS using the conventional Delphi method. MATERIAL AND METHODS: A multidisciplinary panel of 33 experts in the management of HS was selected. A two-round Delphi method was conducted. The first questionnaire consisted of 134 items generated based on a review of the latest international guidelines in the management of HS. RESULTS: Among the 134 items proposed in the first round, 73 have reached a consensual agreement (median ≥7, and 70% or more responses were ≥7). An agreement was reached for 32 items proposed in the second round. A management algorithm was developed based on consensual items. CONCLUSION: The results of this consensus represent a key step in improving the management of patients with HS in North Africa.
J Cutan Aesthet Surg
· 2025 · PMID 40212424
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The eutectic mixture of local anesthetics (EMLAs) is an anesthetic cream frequently used by dermatologists for various aesthetic procedures on a daily basis. Although side effects of EMLA are usually mild local skin reac...The eutectic mixture of local anesthetics (EMLAs) is an anesthetic cream frequently used by dermatologists for various aesthetic procedures on a daily basis. Although side effects of EMLA are usually mild local skin reactions, rare complications such as methemoglobinemia, central nervous system toxicity, and cardiotoxicity can occur. Herein, we are reporting a case of anaphylactic shock to topical application of EMLA.
J Cutan Aesthet Surg
· 2025 · PMID 40212422
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Sebaceous cyst excision is a commonly performed outpatient surgery. Patients are often concerned about intraoperative pain associated with multiple pricks while injecting local anesthesia. Injection of an anesthetic agen...Sebaceous cyst excision is a commonly performed outpatient surgery. Patients are often concerned about intraoperative pain associated with multiple pricks while injecting local anesthesia. Injection of an anesthetic agent with a single prick is reassuring to the patient and encourages the patient to cooperate with the surgeon during the rest of the procedure.
Chauhan K, Tandon M, Kumar A
… +2 more, Taneja N, Hamid SAT
J Cutan Aesthet Surg
· 2025 · PMID 40212421
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Initially, the application of the follicular unit excision (FUE) technique for hair transplantation faced a challenge due to a significant occurrence of hair follicle damage. However, advancements in techniques, punch de...Initially, the application of the follicular unit excision (FUE) technique for hair transplantation faced a challenge due to a significant occurrence of hair follicle damage. However, advancements in techniques, punch designs, and tools have successfully addressed this issue. The integration of motorized equipment featuring rotation, roto-oscillation, oscillation, vibration, suction, and hydration has significantly improved the successful harvesting of grafts. More recently, the adoption of robotic technology for both graft extraction and incision is becoming increasingly common in FUE procedure. Given the wide range of available devices and technologies, hair transplant surgeons may find it challenging to select the most suitable option for their specific practices. The advancements in techniques, punch shapes, and motorized devices have played a key role in reducing the rate of follicle damage and increasing the speed of FUE procedures. It is crucial for hair restoration surgeons to stay informed about the various accessible devices and understand how these tools can be customized to suit the unique hair and skin characteristics of each patient.
J Cutan Aesthet Surg
· 2025 · PMID 40212419
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OBJECTIVES: Dark circles are one of the most common aesthetic concerns in India. While several treatment options exist, none address both volume deficiency and skin quality simultaneously. We felt that fat grafting and n...OBJECTIVES: Dark circles are one of the most common aesthetic concerns in India. While several treatment options exist, none address both volume deficiency and skin quality simultaneously. We felt that fat grafting and nanofat provided a novel treatment option to address both aspects of dark circles in one treatment. MATERIAL AND METHODS: Patient records were examined from 2017 to 2021. A total of 28 patients were identified as having undergone fat grafting and nanofat for dark circles specifically. The patients were analyzed for age, gender, volumes injected, and outcomes based on patient self-assessment. RESULTS: A total of 36 patients underwent fat grafting ranging from the age of 20 to 40 (average 31). All procedures were done under local anesthesia as day care procedures. The volumes injected range from 2 cc/side to 8 cc/side, with an average of 4.36 cc. Using the Likert scale, 28 (77%) rated their results as very satisfied. Six (17%) rated it as satisfied. One rated it as neutral and two rated it as average, and underwent a second session of fat grafting where another 2 cc was injected per side. CONCLUSION: Fat grafting and nanofat are an exciting treatment option for the treatment of dark circles, which is usually regarded as a recalcitrant problem. It has the advantages of addressing both volume and skin quality, being a single-stage procedure, and producing comparatively long-lasting results.
J Cutan Aesthet Surg
· 2025 · PMID 40027542
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This organic model can help develop essential skills required for vitiligo surgery in an affordable and sustainable manner. This study introduces an organic bench model using vegetables to teach and learn vitiligo surger...This organic model can help develop essential skills required for vitiligo surgery in an affordable and sustainable manner. This study introduces an organic bench model using vegetables to teach and learn vitiligo surgery techniques. By using cucumbers , various techniques of dermabrasion and skin grafting were practiced. The model offers a versatile, cost-effective alternative to traditional simulators, enhancing practical skill acquisition.
Bhingradia YM, Gupta S, Ghia D
… +10 more, Shah S, Patel NK, Salim T, Kumari P, Vasudevan B, Shah S, Jain N, Borkhatariya PB, Mitra D, Prasad D
J Cutan Aesthet Surg
· 2025 · PMID 40027541
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Vitiligo is a chronic skin disorder characterized by the loss of melanocytes, leading to depigmented patches on the skin. The global lifetime prevalence of vitiligo diagnosed by a physician or dermatologist was estimated...Vitiligo is a chronic skin disorder characterized by the loss of melanocytes, leading to depigmented patches on the skin. The global lifetime prevalence of vitiligo diagnosed by a physician or dermatologist was estimated at 0•36% in the general population, 0•67% in the adult population adults, and 0•24% in the child population. Vitiligo prevalence was higher in adults than in children across all regions. Central Europe and south Asia reported the highest prevalence 0•52% and 0•52%, respectively, in the general population. Vitiligo significantly impacts patients' quality of life, causing psychological distress and social stigmatization. While medical treatments such as corticosteroids and phototherapy exist, they often fail to achieve satisfactory repigmentation, particularly in extensive or recalcitrant cases. In recent years, surgical interventions have gained prominence as effective alternatives for managing vitiligo. Techniques such as autologous melanocyte transplantation, suction blister grafting, split-thickness skin grafting, and punch grafting offer promising repigmentation results. However, the lack of standardized protocols and guidelines for vitiligo surgery presents challenges in patient selection, procedural approaches, and post-operative care. This study aims to review current surgical techniques, assess patient-specific factors influencing surgical success, and evaluate long-term outcomes, including repigmentation rates and patient satisfaction. Key factors include disease stability, lesion characteristics, and the involvement of exposed areas. Moreover, the study emphasizes the importance of post-operative adjuvant therapy, such as topical tacrolimus and excimer therapy, to enhance surgical outcomes. By establishing evidence-based protocols for vitiligo surgery, this study seeks to improve treatment efficacy and patient care, addressing gaps in current practices and advancing the field toward more consistent and successful outcomes in vitiligo management.
J Cutan Aesthet Surg
· 2025 · PMID 40027540
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Sclerotherapy has been commonly used for the treatment of arteriovenous (AV) malformation as a stand-alone technique or with surgical excision of the nidus. However, it can cause surrounding tissue necrosis and scarring....Sclerotherapy has been commonly used for the treatment of arteriovenous (AV) malformation as a stand-alone technique or with surgical excision of the nidus. However, it can cause surrounding tissue necrosis and scarring. The lip is one of the most uncommon sites for AV malformation. Lip esthesis is of paramount importance. Hence, its reconstruction becomes a difficult task due to its specialized nature. In our technique, we have combined a labial mucosal advancement flap to reconstruct a scarred lip with dermofat grafting to provide an acceptable contour. Therefore, we have combined the principles of reconstruction of the lip with the aesthetic domain in a single stage to replicate a pinkish-red, smooth, and pliable lip with a pout.