J Med Food [JOURNAL]
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200 papers
Anthocyanin-Containing Rose Petal Extract for Photoaging Improvement: A 12-Week Double-Blind Placebo-Controlled Clinical Trial.
Kim HN, Park M, Won K … +6 more , Park Y, Oh M, Lee J, Lee M, Lim TG, Lim W
J Med Food · 2026 Apr · PMID 41788052 · Publisher ↗
Skin photoaging, characterized by wrinkles, loss of elasticity, dryness, and pigmentation, is primarily driven by UV-induced oxidative stress, inflammation, and degradation of extracellular matrix proteins. Polyphenol-ri...
Skin photoaging, characterized by wrinkles, loss of elasticity, dryness, and pigmentation, is primarily driven by UV-induced oxidative stress, inflammation, and degradation of extracellular matrix proteins. Polyphenol-rich botanicals, particularly anthocyanin-containing Jacq. petals, have shown promising antioxidant and collagen-supportive properties in preclinical studies, yet clinical evidence has been lacking. This randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of a standardized petal extract (RPE; NOVAROSE) in 100 healthy men and women aged 25-65 years over 12 weeks. Participants received one tablet per day containing 300 mg of RPE or placebo. Skin parameters were assessed at baseline, week 6, and week 12 using validated instruments. RPE supplementation significantly improved wrinkle indices, skin roughness, elasticity, dermal density, and sagging compared with placebo. Additionally, RPE increased hydration, reduced transepidermal water loss, and decreased stratum corneum desquamation, reflecting enhanced barrier and renewal functions. Additionally, RPE significantly improved skin hydration and barrier function, as evidenced by increased hydration, reduced transepidermal water loss, decreased stratum corneum desquamation, and enhanced skin brightness (L*). Compliance exceeded 95%, and no serious adverse events were reported. These findings provide the first clinical evidence that anthocyanin-containing RPE supplementation yields meaningful improvements in both structural and functional markers of skin health. RPE is a safe, plant-based nutraceutical with potential as a systemic oral strategy for managing photoaging.
Suppressive Effect of Ramat. on Type I Hypersensitivity Reactions and Its Molecular Mechanism.
Mitsuda Y, Kotani S, Wada M
J Med Food · 2026 Mar · PMID 41778644 · Publisher ↗
Ramat. (CM) has long been valued as both an ornamental plant and also for its medicinal and culinary uses. In Japanese folk medicine, a decoction of CM capitulum (CMC) is taken to relieve hay fever symptoms. Previous stu...
Ramat. (CM) has long been valued as both an ornamental plant and also for its medicinal and culinary uses. In Japanese folk medicine, a decoction of CM capitulum (CMC) is taken to relieve hay fever symptoms. Previous studies have confirmed the anti-type I hypersensitivity activity of CMC, although its mechanism of action remains unclear. This study reports that two dried CMC extracts-Hachinohegiku capitulum extracts (HCE) and Abokew capitulum extracts (ACE)-among three edible CM cultivars tested, significantly inhibited passive cutaneous anaphylaxis (PCA), an model of type I hypersensitivity. In mast cell model RBL-2H3 cells, all three extracts, HCE, ACE, and Enmeiraku capitulum extracts (ECE) suppressed antigen-antibody-induced increases in intracellular Ca concentration and degranulation in a concentration-dependent manner. The strength of inhibition correlated with the degree of PCA suppression. Activation of PLCγ1, a key protein in the antigen-antibody signaling cascade, was significantly inhibited only by ACE, which showed the strongest PCA inhibition. Both HCE and ACE significantly reduced Akt activation, whereas ECE, which lacked significant PCA activity, did not inhibit either protein. The degree of protein-activation inhibition corresponded with suppression of Ca elevation, degranulation, and PCA response. These findings suggest that inhibition of PLCγ1 and Akt activation underlies the anti-type I hypersensitivity effects of HCE and ACE.
Nowarta110 Displays Antiviral Properties Against Coxsackievirus B and Herpes Simplex Virus 2.
Sin J, Tran HA, Hoang TX … +4 more , Nguyen AK, Akbarpour F, Han B, Hoang BX
J Med Food · 2026 Aug · PMID 41778632 · Publisher ↗
Nowarta110 is a novel fig extract and colloidal silver therapeutic composition initially designed to treat plantar warts caused by human papilloma virus (HPV). In a recent study, we also demonstrated that our nutraceutic...
Nowarta110 is a novel fig extract and colloidal silver therapeutic composition initially designed to treat plantar warts caused by human papilloma virus (HPV). In a recent study, we also demonstrated that our nutraceutical formulation exhibits potent antitumoral activity in mice xenografted with HPV-transformed cells. Fig extracts have been shown to provide antiviral effects toward a number of viruses; thus, to explore Nowarta110's potential antiviral activity, we evaluated its impact on models of both Coxsackievirus B (CVB) and herpes simplex virus type 2 infections. We found that Nowarta110 significantly reduced infection of human cells with both CVB and herpes simplex virus 2. In all, these findings demonstrate that Nowarta110 possesses antiviral properties against a broad range of viruses. Thus, further studies interrogating its antiviral therapeutic potential are warranted.
Nutrigenomic Insights and Cardiovascular Benefits of Jujube Tree ( L.).
Alla C, Lucau-Danila A, Mehiou A … +5 more , Akissi ZLE, Hilbert JL, Legssyer A, Sahpaz S, Ziyyat A
J Med Food · 2026 Aug · PMID 41778631 · Publisher ↗
has traditionally been used as a phytotherapeutic agent for cardiovascular, metabolic, immune, nervous, and reproductive health. In this study, a multidisciplinary approach combining nutrigenomic analyses, cardiovascula...
has traditionally been used as a phytotherapeutic agent for cardiovascular, metabolic, immune, nervous, and reproductive health. In this study, a multidisciplinary approach combining nutrigenomic analyses, cardiovascular physiology experiments, and phytochemical and ethnobotanical data was employed to investigate the effects of aqueous extract (ZLex). ZLex significantly upregulated genes involved in nitric oxide synthesis (, ), smooth muscle relaxation, and angiotensin degradation, correlating with reductions in systolic, diastolic, and mean arterial blood pressure. In addition, ZLex modulated key neurotransmission-related genes (, , ), supporting its potential anxiolytic and neuroprotective actions. Immune modulation was indicated by the upregulation of genes associated with anti-inflammatory and antimicrobial responses. Metabolic benefits were linked to the regulation of genes involved in glucose and lipid metabolism, mitochondrial function, and body weight control. Positive effects on reproductive health were suggested by the induction of genes implicated in spermatogenesis. These effects are likely mediated by bioactive constituents such as rutin, kaempferol-3-O-rutinoside, 3',5'-di-C-β-glucopyranosylphloretin, a quercetin dirhamnosyl-galactoside, and myricetin-3-O-rutinoside. Altogether, the findings provide mechanistic support for the traditional use of and highlight its therapeutic potential in managing hypertension and other chronic disorders, including diabetes, obesity, and anxiety.
, , and Extracts Protect Against Dexamethasone-Induced Muscle Atrophy Through the Activation of the AKT/mTOR Pathway.
Jang E, Lee TB, Choi S … +5 more , Tonini L, Nam DY, Jung JY, Choi HJ, Ahn C
J Med Food · 2026 Mar · PMID 41758244 · Publisher ↗
Degenerative muscle atrophy leads to reduced muscle mass, strength, and function, increasing the risk of falls and impairing quality of life. While plant-derived compounds possess anti-inflammatory and antioxidant proper...
Degenerative muscle atrophy leads to reduced muscle mass, strength, and function, increasing the risk of falls and impairing quality of life. While plant-derived compounds possess anti-inflammatory and antioxidant properties, their capacity to mitigate muscle atrophy has not been fully explored. This study aimed to evaluate the protective effects of extracts against dexamethasone-induced muscle atrophy. In vivo experiments were conducted using a dexamethasone-induced muscle injury model in mice. Following induction of muscle atrophy, plant extracts were administered for two weeks. Muscle strength was assessed using a grip strength meter, and histological analysis was performed on the gastrocnemius tissues. All three extracts significantly restored grip strength and preserved muscle fiber size. At the molecular level, the extracts suppressed FoxO3a-mediated expression of the atrophy-related genes MuRF1 and MAFbx, while enhancing phosphorylation of Akt and mTOR. Myogenic markers MyoD and Myogenin were also upregulated. Furthermore, similar protective effects were observed in dexamethasone-treated C2C12 myotubes, including recovery of myotube diameter. Mechanistically, the extracts inhibited catabolic signaling through downregulation of FoxO3a and promoted myogenesis via activation of the Akt/mTOR pathway. These findings support the potential therapeutic application of extracts for the prevention and treatment of muscle atrophy.
Anticoagulant Effects of Albiflorin via Factor Xa Inhibition.
Du XX, Jeong YH, Han G … +1 more , Bae JS
J Med Food · 2026 Mar · PMID 41665895 · Publisher ↗
Albiflorin (AF), a primary bioactive compound from the roots of Pall. (Peony), demonstrates anti-inflammatory, antioxidant, and cytoprotective effects. This study aims to investigate the antithrombotic potential of AF a...
Albiflorin (AF), a primary bioactive compound from the roots of Pall. (Peony), demonstrates anti-inflammatory, antioxidant, and cytoprotective effects. This study aims to investigate the antithrombotic potential of AF and clarify its mechanisms of action. Its anticoagulant effects were assessed via activated partial thromboplastin time, prothrombin time, thrombin, and factor Xa (FXa) activities, as well as fibrin formation and platelet aggregation. Additionally, the effect of plasminogen activator inhibitor type 1 and tissue-type plasminogen activator was evaluated in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells (HUVECs). Our experiments revealed that AF exhibited antithrombotic activity comparable to that of rivaroxaban, a well-established direct FXa inhibitor, particularly in suppressing FXa activity and platelet aggregation induced by adenosine diphosphate (ADP) and U46619, a synthetic thromboxane A2 analog. AF also reduced the surface expression of P-selectin, inhibited phosphorylation of myristoylated alanine-rich C kinase substrate, and decreased PAC-1 activation following ADP or U46619 stimulation. Furthermore, AF enhanced nitric oxide production while preventing excess endothelin-1 release in HUVECs exposed to these agonists. experiments in mouse models of arterial and pulmonary thrombosis demonstrated that AF is a potent anticoagulant and antithrombotic agent. These findings indicate that AF could serve as a promising lead compound for developing innovative anti-FXa and antiplatelet therapeutics.
Stimulatory Effects of (+)-Epicatechin on Mitochondrial Biogenesis and Function in Skeletal Muscle of Aged Rats: Underlying Mechanisms.
Ramirez-Sanchez I, Ordoñez-Razo R, Najera V … +2 more , Ceballos G, Villarreal F
J Med Food · 2026 Aug · PMID 41636765 · Publisher ↗
Mitochondrial dysfunction affects skeletal muscle (SkM) function and is critical in the etiology of age-related sarcopenia. The sirtuin 1-PGC1α pathway is a key regulator of mitochondrial mass, structure, and function. H...
Mitochondrial dysfunction affects skeletal muscle (SkM) function and is critical in the etiology of age-related sarcopenia. The sirtuin 1-PGC1α pathway is a key regulator of mitochondrial mass, structure, and function. However, pathway activity decreases with aging. Cacao flavanols show promise in their ability to activate mitochondrial pathways. We evaluated the capacity of the flavanol (+)-epicatechin (+Epi) to stimulate such a pathway and favorably impact mitochondrial and oxidative stress (OS)-associated endpoints in aged SkM. Using 23-month-old male Sprague-Dawley rats, an 8-week oral administration of +Epi (1 mg/kg/day) was implemented, and results were compared versus vehicle-treated controls. Assessments included the nicotinamide adenine dinucleotide (NAD)/sirtuin 1/PGC1α pathway, acetylated proteins levels, mitochondrial function and biogenesis, as well as OS-related endpoints in SkM. +Epi increased the NAD/NADH ratio, activation of sirtuin 1, the deacetylation of nuclear protein content, including that of PGC1α. Also, +Epi induced increases of TFAM and NRF1 mRNA levels, deacetylation of mitochondrial complex I and V, increases in complex I activity, sirtuin 3, complexes I and V, mitofilin, and TFAM protein levels. SkM citrate synthase activity and ATP content increased with +Epi. OS markers in proteins and lipids were reduced, while buffering systems (superoxide dismutase 2 and catalase protein and activities) increased. In white blood cells, we documented serial reductions in mitochondrial DNA content and citrate synthase activity with aging, which were either fully or partially reversed with +Epi. Results demonstrate that +Epi treatment yields positive effects on mitochondrial biogenesis and function, leading to decreased OS and improved SkM bioenergetics in aged rats.
Enhanced Proliferation and Activation of Natural Killer Cells by Deer Antler Velvet Extract, YC-1101, and Its Synergistic Antitumor Effects in CT26 Syngeneic Mouse Model.
Lee JY, Lee J, Yeon D … +9 more , Yoon JS, Hwang SH, Baek SH, Park KH, Song A, Jeong J, Seo JW, Kang J, Park HJ
J Med Food · 2026 Mar · PMID 41636761 · Publisher ↗
Deer antler velvet ( L.) is a traditional material in oriental medicine, extensively utilized for its anti-aging, antioxidant, and immune-boosting properties. Our prior research revealed that enzyme-derived deer antler v...
Deer antler velvet ( L.) is a traditional material in oriental medicine, extensively utilized for its anti-aging, antioxidant, and immune-boosting properties. Our prior research revealed that enzyme-derived deer antler velvet extract (YC-1101) stimulated the immune system by activating macrophages and augmenting splenocyte proliferation. In this study, we investigated the effect of YC-1101 on the proliferation, activation, and cytotoxicity of natural killer (NK) cells, emphasizing activation-receptor upregulation, cytokine secretion, and antitumor efficacy. Our findings demonstrated that YC-1101 treatment markedly enhanced NK cell proliferation in a dose-dependent and time-dependent manner by preserving mitochondrial function. NK cells expanded through YC-1101 treatment exhibited a significant increase in surface expression of activating NK receptors, NKG2D, and NKp44. Additionally, levels of immune-related cytokines like tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor were substantially elevated in the YC-1101-treated group compared with control. Notably, NK cell activation induced by YC-1101 intensified cytotoxicity against various cancer cell lines, and combining YC-1101 with immune checkpoint inhibition synergistically enhanced antitumor activity. Collectively, our results indicate that integration of YC-1101 with expanded NK cells could be a promising approach to augment cancer treatment efficacy.
Structure-Guided Preference Feeding Behavioral Responses of Coumarin Analogs in .
Kim AT, Park Y
J Med Food · 2026 Aug · PMID 41578619 · Publisher ↗
Coumarins are a group of naturally occurring phytochemicals found in various plants with many bioactivities. Recently, it was reported that esculetin (6,7-dihydroxycoumarin) reduced food preference behavior of dependent...
Coumarins are a group of naturally occurring phytochemicals found in various plants with many bioactivities. Recently, it was reported that esculetin (6,7-dihydroxycoumarin) reduced food preference behavior of dependent on the human µ-opioid receptor (MOPR). Thus, this study investigated the structure-activity relationships (SAR) of 17 coumarin analogs using a food preference assay in . While the parent compound, coumarin, and single substitutions at C3, C5, C7, or C8 had no effect, modifications at C4 and C6 were critical for modulating this behavior. Specifically, 4-hydroxycoumarin, 4-methylcoumarin, 6-hydroxycoumarin, 4-hydroxy-6-methylcoumarin, 6,7-dihydroxycoumarin (esculetin), 7-hydroxy-6-methoxycoumarin (scopoletin), and several di-substituted derivatives significantly reduced the preference index, which was abolished in (opioid receptor homolog) knockout strains. Additional determination of preference behaviors was conducted with a strain carrying the human MOPR, which showed results comparable to the wildtype, except for 4-hydroxy-6-methylcoumarin and scopoletin. This work demonstrates the potential antagonistic effects of selected coumarins and the utility of as an model for SAR studies targeting human MOPR.
Black Raspberry and Turcz. Extract Mixture (BLB301) Alleviates Dexamethasone-Induced Muscle Atrophy by Modulating Oxidative Stress and Protein Turnover Pathways.
Park J, Jun W
J Med Food · 2026 Mar · PMID 41574595 · Publisher ↗
This study aimed to evaluate the protective effects of black raspberry (), shady Jerusalem sage ( Turcz.), and their combination (BLB301) on dexamethasone-induced muscle atrophy using both cellular and animal models. In...
This study aimed to evaluate the protective effects of black raspberry (), shady Jerusalem sage ( Turcz.), and their combination (BLB301) on dexamethasone-induced muscle atrophy using both cellular and animal models. In the former, the cytotoxicity and mRNA expression of key anabolic and catabolic markers were evaluated in C2C12 cells subjected to hydrogen peroxide (HO)-induced oxidative stress and treated with the extracts. In the latter, male ICR mice were assigned to the following groups: control (CON), dexamethasone injection (DEX), and DEX receiving 100 mg/kg, 200 mg/kg, or 400 mg/kg BLB301. C2C12 cells treated with BLB301 exhibited higher scavenging activity and expression than the CON and DEX cells. The mice in the DEX group exhibited significantly lower body weight (b.w.), grip strength, and muscle-to-b.w. ratios and higher oxidative stress and catabolic marker (myostatin, atrogin-1, and MuRF1) expression levels than those in the other groups. BLB301 mitigated the foregoing effects in a dose-dependent manner by increasing the antioxidant enzyme activity and decreasing the malondialdehyde levels. It also upregulated key anabolic pathways (PI3K/Akt/mTOR/S6K1) and muscle-specific transcription factors (Myf5, MyoD, and myogenin). BLB301 also downregulated the catabolic markers and restored the balance between protein synthesis and degradation. Therefore, BLB301 alleviates dexamethasone-induced muscle atrophy by modulating oxidative stress and by promoting and inhibiting anabolic and catabolic pathways, respectively. The findings of this study demonstrate the potential of BLB301 as a therapeutic agent for muscle-wasting conditions.
Inhibitory Effects of Hibiscus Acid on Foodborne Bacteria: A Comprehensive Analysis of the Viability, Motility, and Membrane Disruption of Enterohemorrhagic , Typhimurium, and .
Portillo-Torres LA, Bernardino-Nicanor A, Gómez-Aldapa CA … +4 more , Gonzalez-Cruz L, Rangel-Vargas E, Torres-Vitela MR, Castro-Rosas J
J Med Food · 2026 Aug · PMID 41386811 · Publisher ↗
Hibiscus acid has antimicrobial activity against pathogenic bacteria; however, the mechanism of action against these bacteria has not been completely identified. The effect of hibiscus acid on the viability, motility, an...
Hibiscus acid has antimicrobial activity against pathogenic bacteria; however, the mechanism of action against these bacteria has not been completely identified. The effect of hibiscus acid on the viability, motility, and cell membrane of multidrug-resistant enterohemorrhagic , Typhimurium, and was determined. Cell viability was determined by the pour plate technique, and motility was determined by phase contrast microscopy. Acridine orange/ethidium bromide fluorescent staining was performed using a fluorescence microscope to observe live and dead cells. Bacterial cell damage was analyzed by scanning electron microscopy. Finally, nucleotide leakage (DNA and RNA) was evaluated by measuring absorbance at 260 nm using a UV-VIS spectrophotometer. Hibiscus acid treatments (minimum inhibitory concentration [MIC], minimum bactericidal concentration [MBC], 10× minimum inhibitory concentration [10× MIC]) significantly decreased the viable cell counts of the three pathogenic bacterial strains in a time-dependent manner. Hibiscus acid at concentrations of MIC, MBC, and 10× MIC inhibited the motility of bacteria and caused lysis of the bacterial cell membrane. The damage to the membrane was greater as the concentration of hibiscus acid increased. High red fluorescence was found in the cells treated with hibiscus acid at the MIC and 10× MIC, and the release of intracellular material was observed after 2 h of treatment with the three pathogenic bacteria studied. The antimicrobial effect of hibiscus acid was due to the alteration of the membrane permeability of the three pathogenic bacteria studied. Hibiscus acid may represent an alternative to antibiotics for the treatment or prevention of infectious bacterial diseases.
Protects Against Binge-Drinking Alcohol-Induced Liver Injury by Preserving the Intestinal Barrier Integrity.
Kim MC, Kim HR, Kang EJ … +10 more , Noh JR, Choi JH, Choi YK, Lee IB, Choi DH, Seo YJ, Park JS, Oh WK, Kim YH, Lee CH
J Med Food · 2025 Dec · PMID 41364607 · Publisher ↗
Alcoholic liver injury (ALI) is a prevalent and severe form of liver disease that lacks specific therapies, relying instead on supportive care. In ALI, gut epithelial tight junction proteins are compromised, leading to i...
Alcoholic liver injury (ALI) is a prevalent and severe form of liver disease that lacks specific therapies, relying instead on supportive care. In ALI, gut epithelial tight junction proteins are compromised, leading to increased intestinal permeability and the translocation of endotoxins, such as lipopolysaccharides (LPS), into the bloodstream, thereby aggravating liver injury. The plant (SA), part of the family, is recognized for its anti-inflammatory and antioxidant effects but has not yet been studied for potential efficacy in mitigating ALI. In this study, we induced ALI in mice by administering high oral doses of ethanol following pretreatment with or without SA. The SA-treated mice exhibited significantly lower levels of plasma alanine aminotransferase and aspartate aminotransferase, markers indicative of reduced liver damage. Despite observing no notable changes in hepatic fat accumulation or expression of alcohol metabolism-related genes, we found that the SA group exhibited a marked reduction in terminal transferase dUTP nick end labeling-positive hepatocytes and reactive oxygen species within the mitochondrial fraction of liver tissue. Additionally, SA preserved intestinal barrier integrity by upregulating genes associated with tight junctions in the ileum and colon, resulting in lower LPS levels in the blood. Complementary studies with Caco-2 cells further showed that SA pretreatment protected against LPS-induced tight junction disruption by inhibiting NF-κB pathway activation. Collectively, our findings indicate that SA protects against ALI by supporting gut barrier integrity, thereby limiting LPS translocation and hepatic oxidative stress. This study underscores the potential of SA as a therapeutic agent targeting the gut-liver axis.
Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate.
Coman MM, Torbidoni-Baldassari B, Occhigrossi L … +4 more , Deiana G, Silvi S, Verdenelli MC, Napolioni V
J Med Food · 2026 Jul · PMID 41335484 · Publisher ↗
Probiotic supplementation is gaining attention for its role in maintaining health and enhancing the quality of life of the elderly. Leukocyte telomere length (LTL) is a biomarker of cellular aging, with shorter LTL assoc...
Probiotic supplementation is gaining attention for its role in maintaining health and enhancing the quality of life of the elderly. Leukocyte telomere length (LTL) is a biomarker of cellular aging, with shorter LTL associated with cardiovascular morbidity and mortality. This study explored whether probiotics could counteract LTL attrition in an ethnically homogeneous cohort of older adults over a 6-month period. Samples were selected from the PROBIOSENIOR trial, a randomized, double-blind, placebo-controlled study involving 46 participants (≥60 years). Participants were randomized to receive either SYNBIO® probiotics (5 × 10 CFU/daily dose) or a placebo for 6 months. Genomic DNA was extracted from blood samples at baseline, and 6 months later, LTL measures were obtained via quantitative PCR. A general linear model assessed the "treatment x time" interaction as the main outcome. LTL was successfully assessed for all participants ( = 46 × 2 time points). Statistical analysis revealed a significant "treatment x time" interaction ( = .034), indicating a reduced LTL attrition rate in the probiotic group compared with the placebo group. A 6-month supplementation with SYNBIO probiotics significantly reduced LTL attrition in an ethnically homogeneous cohort of elderly adults. These findings suggest that probiotics may serve as a simple and effective intervention to mitigate cellular aging and promote healthy aging.
Effects of Standardized Herbal Extract of , , and (EstroG-100®) on Physical Fatigue and Oxidative Stress and .
Han YY, Oh JH, Kim JM … +5 more , Kim BM, Park CS, Lee YW, Lee M, Lee J
J Med Food · 2025 Dec · PMID 41288471 · Publisher ↗
EstroG-100®, a functional ingredient blend that has been used for menopausal health in women. However, detailed studies on its effects and their underlying mechanisms have been lacking. Herein, we evaluated the antifatig...
EstroG-100®, a functional ingredient blend that has been used for menopausal health in women. However, detailed studies on its effects and their underlying mechanisms have been lacking. Herein, we evaluated the antifatigue effects of EstroG-100 using C2C12 cells exposed to oxidative stress and mice subjected to a forced swimming test. EstroG-100 significantly increased the viability and adenosine triphosphate (ATP) content of C2C12 cells under oxidative stress, while notably inhibiting the generation of reactive oxygen species. EstroG-100 tended to prolong the forced swimming time in mice. It also significantly inhibited the serum lactate dehydrogenase activity, increased intramuscular glycogen content, and upregulated the expression of peroxisme proliferator-activated receptor ( and uncoupling protein ( genes involved in β-oxidation of fatty acids. Furthermore, EstroG-100 significantly increased the activities of antioxidant enzymes, including catalase, superoxide dismutase, glutathione -transferase, and glutathione levels, and decreased the malondialdehyde levels in the liver. These results indicate that EstroG-100 may contribute to recovery from physical fatigue by enhancing the antioxidant activity to alleviate oxidative stress and improving muscle function via modulation of glycogen and fatty acid metabolism.
Chemical Profile and Anti-Obesity Effect of Roem Vinegar in Diet-Induced Obese Mice.
Pan JH, Kim DE, Oh YJ … +3 more , Kim JK, Heo W, Lee JJ
J Med Food · 2025 Nov · PMID 41239751 · Publisher ↗
Obesity represents a major global health concern and is strongly associated with metabolic conditions, including fatty liver disease and cardiovascular disorders. Recent attention has focused on dietary strategies, parti...
Obesity represents a major global health concern and is strongly associated with metabolic conditions, including fatty liver disease and cardiovascular disorders. Recent attention has focused on dietary strategies, particularly bioactive-rich plant-based interventions, to mitigate obesity-related complications. This study aimed to evaluate the anti-obesity effects of vinegar derived from , a medicinal plant with known phytochemical benefits. The physicochemical properties, antioxidant activity, and metabolic effects of vinegar (LV) were assessed through assays using 3T3-L1 adipocytes and an high-fat diet-induced obesity mouse model. LV significantly reduced lipid accumulation in adipocytes. In mice, LV administration attenuated body weight gain, reduced white adipose tissue mass, improved serum lipid profiles, and lowered cardiovascular risk indices. Furthermore, LV exhibited dose-dependent antioxidant activity and modulated key metabolic genes in the liver. These findings suggest that LV may be a functional dietary agent for managing obesity and improving metabolic health.
Clinical Benefits of (BOSMAX®) in Early Knee Osteoarthritis: A Randomized, Placebo-Controlled, Double-Blind Study.
Jayaram M, Kim J, Baek KS … +7 more , Jung H, Kim J, M K P, T S C, H B S, Ramaiah V, S P
J Med Food · 2025 Nov · PMID 41220252 · Publisher ↗
Osteoarthritis (OA) is a major cause of pain and reduced mobility in older adults, with few effective treatments currently available. This randomized, double-blind, placebo-controlled trial evaluated the efficacy and saf...
Osteoarthritis (OA) is a major cause of pain and reduced mobility in older adults, with few effective treatments currently available. This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of extract (BOSMAX®), a botanical anti-inflammatory agent, in participants with non/mild OA. A total of 150 adults aged 40-75 were randomized to receive either BOSMAX® or a placebo daily for 90 days. Primary outcome measures included WOMAC scores, visual analog scale (VAS) for pain, and Lequesne Functional Index; secondary endpoints were SF-36 scores, tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). Significant improvements were observed in the BOSMAX® group compared with the placebo. The mean total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores decreased significantly at days 30 (-6.28), 60 (-15.24), and 90 (-24.55; < .05). WOMAC sub-scores (pain, stiffness, and function) and VAS pain scores also showed significant reductions at days 60 and 90. Lequesne Index scores improved progressively (-1.37, -2.93, and -4.53 at days 30, 60, and 90, respectively; < .05). TNF-α and hs-CRP levels decreased significantly (-104.75 ng/L and -5.67 ng/mL, respectively; < .05) at day 90. However, no significant changes were observed in SF-36 scores. Both treatments exhibited good tolerability, with only one mild and unrelated adverse event reported. Vital signs, physical exams, and laboratory parameters remained clinically unchanged. BOSMAX® significantly improved knee-joint symptoms and inflammatory markers over 90 days in individuals with non/mild OA, supporting its potential as a safe therapeutic option.
Water Extract Inhibits Neuroinflammation Through the p38 MAPK Signaling Pathway in a Systemic LPS-Injection Mouse Model.
Kim JE, Go J, Park HY … +9 more , Min KS, Seo YJ, Lee IB, Park JS, Cho HJ, Kim HS, Oh WK, Kim KS, Lee CH
J Med Food · 2025 Nov · PMID 41204659 · Publisher ↗
Immune responses occurring in the central nervous system as a result of infection or exposure to toxins are referred to as neuroinflammation. It is heavily involved in the pathogenesis of neurodegenerative conditions of...
Immune responses occurring in the central nervous system as a result of infection or exposure to toxins are referred to as neuroinflammation. It is heavily involved in the pathogenesis of neurodegenerative conditions of the brain. In the present study, we investigated the effects of a water extract of (HJW) on neuroinflammation and its fundamental mechanisms in lipopolysaccharide (LPS)-treated BV-2 murine microglial cells and in a mouse model. HJW inhibited LPS-induced secretion of nitric oxide, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α), as well as the mRNA expression of in BV-2 cells. In the group co-administered with HJW, 24 h after LPS administration, a significant downregulation of expression occurred in the cerebral cortex, as well as in TNF-α and IL-6 in the blood. In the group co-administered HJW, microglial activation was effectively suppressed in the cerebral cortex after 24 h of LPS injection and in the hippocampus after 24 h. LPS-induced elevation of phospho-p38 was significantly reduced by administration of HJW to the hippocampus of mice and to BV-2 cells. Furthermore, HJW effectively alleviated cognitive deficits induced by repeated LPS injections in a novel object recognition test. These findings suggest that HJW may offer therapeutic benefits as a natural extract for treating neuroinflammation, thereby enhancing memory and cognitive functions.
Exploring the Biomedical Potential of : A Comprehensive Review of Botanical, Phytochemical, and Pharmacological Aspects.
Albuquerque ER, Braga FA, Martins GB … +8 more , Silva EP, Negrini KS, Yoshitani CME, Kluck AJ, Garnier LP, Silva GRD, Ribeiro-Paes JT, Lívero FADR
J Med Food · 2026 Jul · PMID 41151096 · Publisher ↗
, Cactaceae, is a plant native to temperate and tropical regions. Its leaves and fruits are utilized in food and traditional medicine due to their therapeutic and nutritional properties, which have garnered interest in b...
, Cactaceae, is a plant native to temperate and tropical regions. Its leaves and fruits are utilized in food and traditional medicine due to their therapeutic and nutritional properties, which have garnered interest in both pharmaceutical and food industries. This review provides an overview of the current biomedical research on , encompassing botanical and phytochemical aspects, traditional uses, nutritional evidence, and preclinical pharmacological studies, and toxicological evaluation. Scientific articles were sourced from databases such as PubMed, Science Direct, SciELO, and Web of Science. Saponins, phenolic compounds, and alkaloids emerge as the main bioactive substances within . Nutritionally, its leaves and fruits are valued for their high protein and fiber content. In traditional medicine, its leaves are employed to address various ailments, including headache, gastric pain, hemorrhoids, atopic dermatitis, inflammation, hypertension, diabetes, and cancer. studies on the species have demonstrated antioxidant, cytotoxic, and antimicrobial activity, along with the ability to inhibit the enzyme acetylcholinesterase. research corroborates its diuretic, antihypertensive, antiobesity, and molluscicidal effects. However, there is limited investigation into its toxicity, and notably, no reports of clinical studies with the species were found. In conclusion, while promising effects of have been reported, further research is warranted to substantiate its efficacy in folk medicine as an anticancer, antidiabetic, and antihypertensive agent.
Green Synthesis, Chemical Characterization, and Antiproliferative Effect of Gold Nanoparticles Using Methanolic Extracts of L. Peels.
Alcátar-Ramírez OY, Mendoza-Espinoza JA, Fragoso-Serrano M … +2 more , López-Barrera JA, Pérez-Flores LJ
J Med Food · 2026 Jul · PMID 41144301 · Publisher ↗
The article's aim was thus to evaluate the antiproliferative activity of gold nanoparticles associated with the methanolic extract of in human breast cancer cell line (MCF-7), cervical cancer tissue (HeLa), and colorect...
The article's aim was thus to evaluate the antiproliferative activity of gold nanoparticles associated with the methanolic extract of in human breast cancer cell line (MCF-7), cervical cancer tissue (HeLa), and colorectal cancer cell line (HCT-116) cancer cell lines. The methanolic extract showed the presence of polyphenols and organic acids related to anticancer properties. In relation to the gold nanoparticles functionalized with the methanolic extract of peels, these nanoparticles showed significant cytotoxic activity () in the HCT-116 cell line at 72 h after exposure to these. We consider this the first contribution to the use of the methanolic extract of for the green synthesis of gold nanoparticles. In conclusion, the green synthesis of gold nanoparticles associated with methanolic peel extract may be an interesting option for the search for new cancer treatments.
The Effect of Fruit Extract for Antioxidant and Anti-Melanogenic Activities and Phytochemical Profiling Using LC-MS Analysis.
Tangpudtasiri P, Wiriyakun N, Niwaspragrit C … +4 more , Amornlerdpison D, Namchaiw P, Ratanachamnong P, Jaisin Y
J Med Food · 2025 Oct · PMID 41144290 · Publisher ↗
( Blume is commonly found in Southern and Eastern Asia, including Thailand. This plant is commonly known as "Carabao teats" in English and "Pee Puan" in Thai. Even though hyperpigmented skin is generally a harmless condi...
( Blume is commonly found in Southern and Eastern Asia, including Thailand. This plant is commonly known as "Carabao teats" in English and "Pee Puan" in Thai. Even though hyperpigmented skin is generally a harmless condition, it is often a cosmetic concern. Ultraviolet exposure seems to be the primary contributing factor. In this study, we investigated the bioactive constituents of the ethanol extract of fruits and evaluated their anti-melanogenic effects and tyrosinase inhibition in B16F10 mouse melanocyte cells (B16F10 melanoma cells) induced by α-melanocyte-stimulating hormone (α-MSH). This extract included phenolic and flavonoid components, as well as secondary metabolites demonstrated using LC-MS analysis, including betaine, hydroquinone, kojic acid, nicotinamide, quercetin, cysteamine, neoagarobiose, gallic acid, and cinnamic acid. Based on its antioxidant constituents and preliminary antioxidant screening, the extract possessed free radical scavenging capability by effectively scavenging DPPH and nitric oxide (NO) radicals with an IC of 7.05 and 16.56 mg/mL, respectively. The extract inhibited melanin production by 123.2 ± 3.3% and tyrosinase activity by 134 ± 4.23% in α-MSH-stimulated B16F10 cells, suggesting that the observed anti-melanogenic capability arises from the combined action of several bioactive substances. Taken together, this present study demonstrates that fruits have potential as a natural anti-melanogenic remedy and supports its further development for applications in the treatment of hyperpigmentation.
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