J Med Food [JOURNAL]
Sun
200 papers
Diet Quality Assessment Using the Korean Healthy Eating Index in Relation to Alcohol Consumption Patterns in Korean Adults.
Choi MK, Bae YJ
J Med Food · 2025 Oct · PMID 41103248 · Publisher ↗
Previous studies have reported associations between alcohol consumption patterns and diet quality. However, this study expanded previous knowledge by investigating the relationship between alcohol consumption patterns-ca...
Previous studies have reported associations between alcohol consumption patterns and diet quality. However, this study expanded previous knowledge by investigating the relationship between alcohol consumption patterns-categorized by frequency and amount of alcohol consumption-and diet quality, assessed by using the Korean Healthy Eating Index (KHEI), among Korean adults aged 30-64 years. A total of 7885 adults (3469 men and 4416 women) from the 2019-2021 Korea National Health and Nutrition Examination Survey were included. Drinking patterns were classified based on frequency and quantity, and their association with diet quality was compared to that of abstainers. In both men and women, infrequent heavy drinkers, more frequent moderate/light drinkers, and more frequent heavy drinkers had significantly lower scores for total and fresh fruit intake, and higher scores for calories from sweets and beverages than abstainers. Among women, the odds of being in the lowest KHEI quartile (Q1) compared to the highest (Q4) were significantly higher for infrequent heavy drinkers (adjusted odds ratio [AOR] = 1.61; 95% confidence interval [CI]: 1.08-2.39), more frequent moderate/light drinkers (AOR = 1.65; 95% CI: 1.05-2.58), and more frequent heavy drinkers (AOR = 2.54; 95% CI: 1.44-4.49). These findings suggest that frequent drinking and higher intake per occasion are associated with lower consumption of fresh fruit and poorer overall diet quality. In women, both frequent drinking and high consumption during infrequent drinking occasions were more strongly associated with poor diet quality, highlighting the need for stricter dietary guidance related to alcohol consumption.
Functional-Diet Potential of Black Cumin-Enriched Acha-Based Cookies on -Infected Diabetic Mice.
Nwanna EE, Olanrewaju BT, Oyeleye IS … +2 more , Ojueromi OO, Oboh G
J Med Food · 2026 Jul · PMID 41084305 · Publisher ↗
The prevalence of diabetes and malaria remains high in developing countries despite remarkable progress in the health sector. Functional food remedies with acha grains and black cumin have been used locally to treat/mana...
The prevalence of diabetes and malaria remains high in developing countries despite remarkable progress in the health sector. Functional food remedies with acha grains and black cumin have been used locally to treat/manage type 2 diabetes (T2D) and malaria separately. However, this study sought to assess the comorbidity and the ameliorative potential of black cumin-enriched acha-based cookies in infection in diabetic mice. High-fat diet fed mice of 20-25 g were grouped into eight groups ( = 8), while a single dose of streptozotocin (35 mg/kg) was intraperitoneally administered to induce T2D. After this, the NK65 strain of was used to infect the mice, and the infected diabetic mice were fed with the formulated cookies for 14 days, and the percentage (%) parasitemia suppression and blood glucose levels were evaluated at 3-day intervals in the morning. The effect of the cookies on pancreatic α-amylase, α-glucosidase, endogenous antioxidant enzymes (superoxide dismutase), catalase, glutathione peroxidase activities, reduced glutathione level, and inflammatory nuclear factor kappa-light-chain-enhancer and interleukin-10 markers was determined. The result of the malaria-infected diabetic mice fed with a fortified cookies diet indicates a reversal of damage incurred compared with the negative control group. This shows that black cumin-enriched acha-based cookies could be a promising nutraceutical therapy in T2D-malaria pathology.
Influence of Bean Flour () on Cardiac Remodeling after Acute Myocardial Infarction in Rats.
Vieira NM, Monte MG, Balin PDS … +12 more , Campos DHS, Cabral Filho RP, Fujimori ASS, Ribolla PEM, Alonso DP, Correa CR, Azevedo PS, Polegato BF, Paiva SAR, Zornoff LAM, Okoshi K, Minicucci MF
J Med Food · 2026 Jul · PMID 41083422 · Publisher ↗
Despite the introduction of new drugs, cardiac remodeling (CR) following myocardial infarction (MI) is still associated with increased mortality. Therefore, the search for new therapeutic strategies and bioactive compoun...
Despite the introduction of new drugs, cardiac remodeling (CR) following myocardial infarction (MI) is still associated with increased mortality. Therefore, the search for new therapeutic strategies and bioactive compounds capable of attenuating CR is highly relevant. Although the underlying mechanisms are not fully understood, growing evidence suggests that oxidative stress regulation and modulation of the intestinal microbiota may contribute to the cardioprotective effects of bean consumption in cardiovascular diseases. We investigated the influence of bean flour on CR and intestinal microbiota after MI. Male Wistar rats underwent experimental infarction or sham surgery and were allocated into (1) Sham fed a standard diet (C = 18); (2) MI fed a standard diet (I = 22); and (3) MI fed a diet with bean flour (IB = 28) 15%. After 3 months were submitted to functional, morphometric, and biochemical study. The average infarct size was 38% for the I group and 40% for the IB group, there being no difference between the groups. The MI groups presented morphological changes and functional variables compared with C. Beans did not attenuate these changes, however, microbiota, the S24-7 Bacteroides, and the Halobacteriaceae firmicutes had reduced abundance after the MI in IB group. The supplementation of bean flour modulates the intestinal microbiota after MI. However, it does not attenuate the CR process following MI.
Tea from Pods with Seeds of (Jucá) Does Not Attenuate Inflammatory Reaction of Acute Colitis in Rats.
Fagiani MAB, Andrade APM, Pereira ACP … +10 more , Zulli AS, Estopa BME, Rosa BLG, Mello FA, Gonçalves GV, Ferreira IB, Pereira LG, Genaro SC, Santarém CL, Lenquiste SA
J Med Food · 2026 Jul · PMID 41060827 · Publisher ↗
This study aimed to evaluate the effects of Jucá tea for curative treatment in rats with acute colitis. A total of 40 male rats ( = 10 per group) were fed a commercial ration and filtered water, wherein one group receiv...
This study aimed to evaluate the effects of Jucá tea for curative treatment in rats with acute colitis. A total of 40 male rats ( = 10 per group) were fed a commercial ration and filtered water, wherein one group received Jucá tea by gavage. The rats were divided into the following groups: control, colitis control, drug control receiving sulfasalazine, and Jucá group, where the rats received an intermediate dose of the fruit (285 mg/kg/day). The disease activity index, macroscopic damage score of the large intestine (LI), histopathological analysis of the LI, biochemical examinations, and antioxidant measurements were performed. The group that received Jucá tea exhibited reduced water and feed consumption ( = .000) and presented a higher index of disease activity on days 1 ( = .000) and 7 ( = .004). Additionally, this group presented more severe intestinal lesions on histopathological evaluation of the total damage score ( = .017). The intestinal crypts were not negatively affected by tea consumption ( = .001). Jucá did not cause hepatic alterations in rats, as verified by alanine aminotransferase measurement ( = .04), but lowered albumin levels ( = .00). Jucá tea alters the dietary consumption in animals, is implicated in intestinal damage, and does not soften the inflammatory process caused by colitis. Jucá does not induce hepatotoxicity.
Almond Consumption on HDL Cholesterol and CVD Risk Factors in Adults with High Cholesterol: A Randomized, Comparator-Controlled Trial.
Doma KM, Moulin M, Crowley DC … +2 more , Guthrie N, Lewis ED
J Med Food · 2025 Dec · PMID 41060820 · Publisher ↗
Dietary modifications are recommended for individuals with hypercholesterolemia to reduce cardiovascular disease (CVD) risk. While almonds have been shown to improve certain CVD risk factors, the effects of almonds on hi...
Dietary modifications are recommended for individuals with hypercholesterolemia to reduce cardiovascular disease (CVD) risk. While almonds have been shown to improve certain CVD risk factors, the effects of almonds on high-density lipoprotein cholesterol (HDL-C) are less clear. This study aimed to determine the quantity of almonds that would provide optimal increases in HDL-C in a population with hypercholesterolemia. Participants were randomized ( = 25/group) to low-dose almond (LDA; 1.5 oz/day), high-dose almond (HDA; 2.5 oz/day), or nut-free diet (NFD; cookies isocaloric to LDA) for 16 weeks. Change in HDL-C (primary outcome), Framingham Risk Score (FRS), blood pressure (BP), apolipoproteins, anthropometrics, and serum α-tocopherol were assessed at baseline and weeks 4, 8, 12, and 16. There were no significant differences in HDL-C between groups; however, there were reductions in FRS of 1.4% and 0.6% from baseline at week 16 in the HDA and LDA groups ( ≤ .05), respectively, while the NFD group had a 1.0% decrease ( = .14). There were decreases of 4.7 mmHg, 4.1 mmHg, 5.1 mmHg, and 3.8 mmHg in systolic BP for the HDA group after 4, 8, 12, and 16 weeks, respectively ( ≤ .06), which was significantly lower than the NFD group from baseline at week 8. The NFD group had increases in sagittal abdominal diameter of 4.0% and 2.7% after 4 and 8 weeks ( ≤ .05), respectively, whereas the almond groups did not. Findings suggest almond consumption may support dietary strategies for improving CVD risk factors in adults with hypercholesterolemia.
Antibacterial Activity of Hibiscus Acid Alone and Combined with Chloramphenicol in CD-1 Mice Infected with Multidrug-Resistant Enterohemorrhagic and Typhimurium.
Portillo-Torres LA, Mercado-Monroy J, Bernardino-Nicanor A … +4 more , Gómez-Aldapa CA, González-Cruz L, Rangel-Vargas E, Castro-Rosas J
J Med Food · 2026 Jul · PMID 41026582 · Publisher ↗
The antibacterial effect of chloramphenicol, hibiscus acid, and a mixture of hibiscus acid and chloramphenicol against antibiotic-resistant enterohemorrhagic (EHEC) and Typhimurium (ST) was determined in Caesarean-Deri...
The antibacterial effect of chloramphenicol, hibiscus acid, and a mixture of hibiscus acid and chloramphenicol against antibiotic-resistant enterohemorrhagic (EHEC) and Typhimurium (ST) was determined in Caesarean-Derived (CD)-1 mice. Hibiscus acid was isolated from calyces. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of chloramphenicol (CH), hibiscus acid (HA), and mixtures of HA/CH were determined for EHEC and ST. 11 groups of six mice each were formed. Four groups were inoculated orally with 4 log Colony forming units (CFU) of ST, four groups were inoculated with 4 log CFU of EHEC, and the remaining three groups were not inoculated. Six hours post inoculation, the mice in some groups received, via the oral route, solutions of hibiscus acid (7 mg/mL), chloramphenicol (82 µg/mL), a mixture of HA/CH (5.7 mg/mL HA and 4 µg/mL CH), or isotonic saline solution. The MIC and MBC values were between 7 and 5 mg/mL for hibiscus acid, between 17.6 and 82 µg/mL for chloramphenicol, and between 4.2 mg/mL/0.3 µg/mL and 5.7 mg/mL/0.4 µg/mL (concentration of hibiscus acid/concentration of chloramphenicol) or HA/CH. EHEC and ST were not detected in the feces of mice that were administered hibiscus acid alone or in mixture with chloramphenicol. By contrast, pathogens were isolated from the feces of untreated mice and those treated with chloramphenicol alone throughout the study.
Curcumin Inhibits Bisphenol A-Induced Fat Mass Gain by Enhancing White Adipose Tissue Browning via Modulating Gut Microbiota-Dependent Bile Acid Metabolism in CD-1 Mice.
Chen X, Zou J, Cao Z … +6 more , Hong T, Zhang H, Yang J, Mai H, Li X, Feng D
J Med Food · 2025 Dec · PMID 41026579 · Publisher ↗
Chronic exposure to low-dose bisphenol A (BPA) has emerged as a pressing worldwide public health concern. Our previous work demonstrated that low-dose BPA exposure caused gut microbiota dysbiosis and liver fat accumulati...
Chronic exposure to low-dose bisphenol A (BPA) has emerged as a pressing worldwide public health concern. Our previous work demonstrated that low-dose BPA exposure caused gut microbiota dysbiosis and liver fat accumulation. Curcumin is a polyphenol extracted from the rhizome of turmeric and has an inhibitory effect on liver fat accumulation and obesity. This study aimed to investigate the protective effects of curcumin against BPA-induced fat mass gain and obesity and gut microbiota-dependent bile acid (BA) metabolic mechanism. Male CD-1 mice were fed a diet containing a low dose of BPA (50 µg/kg/day) with or without 0.1% w/w curcumin for 24 weeks. Curcumin supplementation markedly decreased the fat mass of inguinal white adipose tissue (iWAT) and the ratio of iWAT weight to body weight in BPA-exposed mice. Curcumin-treated mice exhibited decreased Firmicutes/Bacteroidetes ratio and increased relative abundance of , and , which are related to BA metabolism. Moreover, serum levels of lithocholic acid, the most potent activator of Takeda G protein-coupled receptor 5 (TGR5), and TGR5 expression in iWAT were significantly increased following curcumin intervention. Activation of TGR5 elevated cyclic adenosine monophosphate levels, subsequently up-regulating the expression of iodothyronine deiodinase 2 and fibroblast growth factor 21. These changes increased the expression of uncoupling protein 1 (UCP1), ultimately leading to enhanced iWAT browning and reduced fat mass in iWAT. These results indicated that curcumin suppressed BPA-induced fat mass gain by enhancing iWAT browning by activating gut microbiota-BA-TGR5/UCP1 pathways, supporting its potential as a nutritional therapy for BPA-induced obesity.
Whole Montmorency Tart Cherry Smoothie Improves Disease Activity Index in Rat Model of DSS-Induced Ulcerative Colitis by Downregulating the Janus Kinase 1 and Interleukin-17A.
Coronel J, Toc M, Guice J … +5 more , Raggio A, Keenan MJ, Greenway F, Coulon D, Losso JN
J Med Food · 2025 Dec · PMID 41022545 · Publisher ↗
Montmorency tart cherries (TC; ) are a good source of anti-inflammatory flavonoids. The aim of this research was to evaluate the protective effect of TC against ulcerative colitis (UC) in a rat model. The anthocyanin pro...
Montmorency tart cherries (TC; ) are a good source of anti-inflammatory flavonoids. The aim of this research was to evaluate the protective effect of TC against ulcerative colitis (UC) in a rat model. The anthocyanin profile and content of TC were analyzed by UHPLC-PDA-MS. Rats were randomly assigned to one of eight groups ( = 6 in each group). UC was induced by adding 4% dextran sulfate solution (DSS) to the drinking water for 5 days. For the prevention, intervention, or treatment group, TC was administered orally in one or two servings (155 or 310 g of cherries/70 kg body weight/day) for 2 weeks prior to DSS administration, during the DSS administration, or after the DSS administration. Cytokines were determined by multiplex bead assay. Cyanidin-3-glucosyl-rutinoside and cyanidin-3-rutinoside were the major anthocyanins in TC extracts. TC at one or two servings reduced leukocyte infiltration in the colon. TC, as a prevention, intervention, or treatment, significantly reduced the secretion of myeloperoxidase, interleukin (IL)-6, IL-12/p40, IL-17A, tumor necrosis factor-α (TNF-α), and Janus kinase 1 (JAK1) and increased the secretion of anti-inflammatory IL-10 and JAK3. IL-1β was not significantly reduced by TC. Whole TC improved intestinal barrier function/disease activity index in UC by inhibiting IL-17A, IL-6, IL-12/p40, JAK1, and TNF-α and increasing IL-10 and JAK3 in UC rat models. TC was not inflammatory in control rats. TC has clinical potential for the treatment of UC.
Ginseng Berry Concentrate Alleviates Fatigue in Humans: A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial.
Nam HJ, Park SH, Kim A … +5 more , Kim SH, Park JH, Jeong HW, Sohn JH, Joa KL
J Med Food · 2025 Dec · PMID 41022533 · Publisher ↗
Ginseng berry concentrate (GBC) is known to effectively reduce fatigue; however, its effects on fatigue in humans remain poorly understood. In this study, we aimed to evaluate the antifatigue effects of GBC in participan...
Ginseng berry concentrate (GBC) is known to effectively reduce fatigue; however, its effects on fatigue in humans remain poorly understood. In this study, we aimed to evaluate the antifatigue effects of GBC in participants who experienced fatigue in their daily lives. Eighty-eight participants aged 30-64 years with checklist individual strength (CIS) scores above 76 were randomly assigned to receive either four capsules of GBC (1000 mg; = 44) or placebo ( = 44) daily for 8 weeks. GBC treatment alleviated fatigue symptoms in participants experiencing daily fatigue, as indicated by improvements in numeric rating scale (NRS) and CIS-physical activity scores, which were associated with lower resting lactic acid levels, a known fatigue indicator. Furthermore, in a subgroup analysis excluding 14 participants taking musculoskeletal drugs, GBC treatment alleviated fatigue as evidenced by lower total scores for fatigue questionnaires, including CIS, fatigue severity scale, and NRS, as well as by lower resting lactic acid levels. Collectively, these results demonstrate the safety and efficacy of GBC for ameliorating fatigue symptoms in individuals with fatigue.
Comparison of Blood Parameters Between Omnivores and Lacto-Ovo Vegetarians Post-COVID-19: A Pilot Study Done in a Country City in the South of Brazil.
Santana Quinto B, Bertolassi MA, Março PH
J Med Food · 2025 Nov · PMID 41020704 · Publisher ↗
Among the most significant comorbidities associated with the progression of COVID-19 to more severe stages, studies have reported a high prevalence of overweight and obesity, often resulting in complications that require...
Among the most significant comorbidities associated with the progression of COVID-19 to more severe stages, studies have reported a high prevalence of overweight and obesity, often resulting in complications that require hospitalization and intensive care. As obesity can, in many cases, be linked to lifestyle, dietary habits may influence physiological parameters, particularly in the period following viral infections such as COVID-19. This pilot study aimed to compare the blood parameters of individuals with different dietary patterns (omnivores and lacto-ovo vegetarians) after COVID-19 infection using principal component analysis (PCA). All participants were residents of the same city (Campo Mourão, Paraná State, Brazil) and were infected during a similar time period (January 2022 ± 2 months). Blood analysis data were collected from 20 volunteers, all evaluated at the same clinical analysis laboratory. The parameters assessed included leukocytes, red blood cells, hemoglobin, hematocrit, erythrocytes, platelets, total cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, low-density lipoprotein (LDL) cholesterol, glucose, ferritin, vitamin B12, vitamin D, vitamin C, and calcium. PCA results indicated distinct differences in blood profiles between most lacto-ovo vegetarians and omnivores. Lacto-ovo vegetarians were associated with higher levels of HDL cholesterol, ferritin, glucose, platelets, and hematocrit, while omnivores showed higher levels of LDL cholesterol, total cholesterol, vitamin B12, vitamin D, and hemoglobin. Among the parameters evaluated, only vitamin D showed a statistically significant difference between the groups ( < .05). These preliminary findings suggest that dietary patterns may influence certain blood parameters in the post-COVID-19 recovery period. Further research with a larger sample size is needed to confirm these associations and to better understand the potential role of diet in postinfection metabolic responses.
Wild Cordyceps Polysaccharides Alleviate Atherosclerosis by Attenuating Macrophage Cholesterol Accumulation Through the PPARγ-LXRα-ABCA1/ABCG1 Pathway.
Liu S, Yang C, Zhou X … +5 more , Yang X, Li X, Li Y, Bai J, Yang J
J Med Food · 2025 Nov · PMID 40982245 · Publisher ↗
Cordyceps has been clinically used to treat atherosclerosis (AS) since the 1980s. However, the active components responsible for its effects and the underlying mechanisms remain poorly understood. In this study, we aimed...
Cordyceps has been clinically used to treat atherosclerosis (AS) since the 1980s. However, the active components responsible for its effects and the underlying mechanisms remain poorly understood. In this study, we aimed to explore the anti-AS effects and mechanisms of action of wild Cordyceps polysaccharides (WCP). The molecular weight, monosaccharide composition, and structural characteristics of WCP were analyzed. Furthermore, the anti-AS effects of WCP were evaluated using apolipoprotein E knockout () mice fed high-fat diets. The mechanisms underlying WCP's anti-atherosclerotic activity were elucidated in mice and oxidized low-density lipoprotein-loaded RAW264.7 macrophages. We found that WCP is composed of galactose, glucose, and mannose, with a molar ratio of 1:1.1:1.2. The average molecular weights of WCP are 1486 and 26 kDa. WCP significantly attenuated the progression of AS, as evidenced by reduced plaque formation in the aortic root valve area. Notably, WCP reduced cholesterol accumulation in macrophages by upregulating the expression of ATP-binding cassette transporter protein 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1), both and . Importantly, we identified peroxisome proliferator-activated receptor-gamma (PPARγ) as a critical target of WCP in macrophages, as confirmed by siRNA knockdown experiments. The ability of WCP to enhance the expression of cholesterol efflux-related genes in macrophages was markedly diminished upon suppression of PPARγ expression. In conclusion, our findings suggest that WCP mitigates the development of AS by activating the PPARγ-liver X receptor alpha (LXRα)-ABCA1/ABCG1 pathway, thereby reducing cholesterol accumulation in macrophages. This study provides new insights into how Cordyceps polysaccharide exerts anti-atherosclerotic effects and highlights its potential as a therapeutic agent for AS.
Comparing the Bioavailability of Two Seawater-Derived Magnesium Preparations.
McFarlin BK, Paschall AL, Kelly ME … +1 more , Womack SM
J Med Food · 2025 Dec · PMID 40955524 · Publisher ↗
Magnesium deficiency is a common problem worldwide; however, existing magnesium dietary supplement sources require large doses to overcome low bioavailability. Previously research has established that seawater contains m...
Magnesium deficiency is a common problem worldwide; however, existing magnesium dietary supplement sources require large doses to overcome low bioavailability. Previously research has established that seawater contains magnesium in addition to 72 other trace and ultratrace minerals, resulting in better bioavailability than traditional magnesium sources. The purpose of the present study was to compare the bioavailability of magnesium obtained from two different seawater processing methods (hydroxide vs. citrate). In a double-blind manner, healthy, young men and women ( = 20) completed three trials using a crossover design: placebo (maltodextrin), seawater magnesium citrate (Aquamin®-Mg; min 10% elemental magnesium), and seawater-derived magnesium hydroxide (Aquamin®-MgTg; min 33% elemental magnesium). Total magnesium doses were standardized on the Recommended Daily Allowance (RDA) for elemental magnesium. An incremental, 18-h urine magnesium excretion test was used to assess relative magnesium bioavailability. The urine uptake was verified by short-term serum magnesium measurements (1- and 2-h postingestion). Serum and urine magnesium concentration were analyzed in triplicate using a colorimetric assay. We found that both seawater-derived magnesium preparations significantly increased magnesium absorption compared with placebo (>97% change) but did not differ from each other when standardized on magnesium dose. The magnesium hydroxide form may be particularly useful since its greater magnesium content allows for ingestion of smaller total quantities compared to soluble magnesium citrate.
Cardiovascular Evaluations of a Mixed Extract of and Pall. (USCP-GVH-014): A 12 Weeks Clinical Perspective.
Chai H, Son J, Song S … +5 more , Cha MR, Oh B, Kim S, Lee HG, Kim SA
J Med Food · 2025 Dec · PMID 40928999 · Publisher ↗
and Pall. are traditionally used to manage cardiovascular health. However, clinical evidence evaluating standardized extracts for specific cardiovascular benefits is still evolving. This study aimed to evaluate its effi...
and Pall. are traditionally used to manage cardiovascular health. However, clinical evidence evaluating standardized extracts for specific cardiovascular benefits is still evolving. This study aimed to evaluate its efficacy and safety of a mixed extract of and Pall. (USCP-GVH-014) for improving cardiovascular function in adults with early-stage vascular health decline. This 12-week, single-center, single-arm, prospective exploratory clinical trial enrolled 30 adults with at least two risk factors. Participants consumed USCP-GVH-014 (1200 mg/day), and outcomes included systolic blood pressure (SBP), carotid intima-media thickness (CIMT), lipid metabolism markers, and inflammatory markers, which were assessed at baseline, 6 weeks, and 12 weeks. USCP-GVH-014 significantly reduced SBP over time ( = .013), particularly at 12 weeks ( = .007). Total cholesterol significantly decreased at 6 weeks ( = .035), though the effect was not sustained at 12 weeks. Low-density lipoprotein cholesterol demonstrated a significant overall reduction ( = .031), but post-hoc comparisons did not confirm the significance between specific time points. CIMT significantly decreased after 12 weeks ( < .001). Additionally, improvements were observed in mean arterial pressure ( = .008), pulse pressure ( = .04), heart rate ( = .013), and right pulse wave velocity ( = .043). No serious adverse events related to the product were reported. USCP-GVH-014 may enhance vascular health by lowering SBP, reducing CIMT, and modulating lipid metabolism, highlighting its potential as a functional ingredient for cardiovascular health support.
Salmon Nasal Cartilage-Derived Proteoglycans Alleviate Cartilage Degeneration in Osteoarthritis by Modulating Inflammation and Apoptosis.
Kim J, Park J, Park SH … +5 more , Gwon Y, Kim J, Nakano H, Okazaki T, Lee M
J Med Food · 2025 Nov · PMID 40899317 · Publisher ↗
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage damage, inflammatory responses, and apoptosis of chondrocytes. In this study, we investigated the therapeutic potential p...
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage damage, inflammatory responses, and apoptosis of chondrocytes. In this study, we investigated the therapeutic potential properties of proteoglycans (PG) extracted from salmon nasal cartilage in both (HTB-94 human chondrocytic cells) and (monosodium iodoacetate-induced OA rat model) approaches. Rats were treated with PG, and key parameters related to cartilage integrity, inflammation, and apoptosis were evaluated. Our results showed that PG treatment significantly improved cartilage structure and decreased inflammation, as evidenced by decreased levels of PGE and nitric oxide, as well as reduced expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1, and interleukin-6. PG also downregulated matrix metalloproteinases while increasing tissue inhibitors of metalloproteinases, preserving cartilage integrity. Additionally, apoptotic signaling pathways including JNK/c-Fos/c-Jun and FADD/capase-8/caspase-3 were attenuated, and the Bax/Bcl-2 ratio was favorably modulated by PG. These findings suggest that PG can protect articular cartilage by mitigating inflammation, preserving cartilage degradation, and preventing chondrocyte apoptosis. This study supports the potential therapeutic role of PG as a promising treatment option for OA, providing both anti-inflammatory and chondroprotective effects.
pb2441 Ameliorates Hepatic Steatosis by Decoupling Liver and Fat Tissue Lipid Accumulation in a High-Fat Diet-Fed Mouse Model.
Lee JY, Park SS, Cho IK … +2 more , Moon KS, Cho Y
J Med Food · 2025 Dec · PMID 40899311 · Publisher ↗
Nonalcoholic fatty liver disease (NAFLD) is a global health issue, often associated with gut dysbiosis. In recent years, probiotics have gained attention as potential therapeutic agents for NAFLD. This study explored the...
Nonalcoholic fatty liver disease (NAFLD) is a global health issue, often associated with gut dysbiosis. In recent years, probiotics have gained attention as potential therapeutic agents for NAFLD. This study explored the effects of a single strain, with high surfactin secretion, on C57BL/6 mice fed a high-fat diet (HFD), a model for NAFLD, for 13 weeks. We conducted efficacy assays over 13 weeks on liver fat accumulation and gut microbiome modulation. supplementation reduced body weight gain and fat accumulation in the liver, but not in adipose tissues. This indicates a decoupling of hepatic and adipose lipid accumulation-meaning that lipid reduction occurred selectively in the liver, independent of changes in peripheral fat storage. Hepatic steatosis and liver enzyme levels were significantly improved. The supplementation largely maintained or amplified the bacterial abundance shifts caused by the HFD. Only seven-including , , and -out of 53 bacterial genera which were significantly changed by HFD were restored to normal levels by the supplementation. These three genera are commonly regarded as beneficial for human health due to their roles in gut barrier integrity, immune modulation, and metabolic regulation. In contrast, despite these limited changes in bacterial composition, bacterial enzyme analysis suggested significant metabolic modulation by supplementation. A single strain of , instead of a mixture of multiple bacterial strains, can prevent hepatic steatosis without affecting fat tissue weight, underscoring its potential as a targeted therapeutic option through microbiome modulation of a few beneficial bacteria.
Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice.
Koo J, Lee C, Kim J … +3 more , Gwon Y, Lim W, Lim TG
J Med Food · 2025 Dec · PMID 40865543 · Publisher ↗
Hair loss is characterized by reduced hair thickness, decreased density, and delayed growth and is associated with factors such as aging, stress, and environmental influences. This study investigated the effects of Gly-P...
Hair loss is characterized by reduced hair thickness, decreased density, and delayed growth and is associated with factors such as aging, stress, and environmental influences. This study investigated the effects of Gly-Pro-Val-Gly-Pro-Ser low molecular weight fish collagen peptide (FC) on improving hair health and alleviating hair loss. Human dermal papilla cells and C57BL/6 mice were used as experimental models. Mice were administered FC at doses of 200, 400, and 800 mg/kg body weight, followed by protein and RNA analyses and histological evaluations. The results showed that FC significantly increased the expression of vascular endothelial growth factor, PCNA, Hepatocyte growth factor, endothelial growth factor, and insulin-like growth factor 1, which play essential roles in hair follicle growth and regeneration. Additionally, FC administration reduced the expression of specific proteins negatively associated with hair health. Histological and morphological analyses revealed that FC enhanced hair follicle size, density, and overall hair quality. These findings suggest that FC may promote hair growth and regeneration.
A Combination of Fruit Rind and Seed Extracts Ameliorates Obesity in High-Fat Diet-Fed Rats via the AMPK Pathway.
Kim S, Kundimi S, Rao T … +3 more , Veeramachaneni S, Ramanathan G, Koo YK
J Med Food · 2025 Nov · PMID 40865057 · Publisher ↗
In the present study, we investigated the anti-obesity effects of LN19183, a combination of extracts of fruit rind and seed, and . Oil Red O staining and Western blotting were performed on 3T3-L1 adipocytes to examine...
In the present study, we investigated the anti-obesity effects of LN19183, a combination of extracts of fruit rind and seed, and . Oil Red O staining and Western blotting were performed on 3T3-L1 adipocytes to examine the inhibitory effects on lipid accumulation and the underlying mechanisms. Additionally, LN19183, along with a high-fat diet, was administered to rats for 28 days, and body weight and serum biochemical profiles were assessed. study results showed that LN19183 significantly reduced lipid accumulation in a dose-dependent manner. Moreover, treatment with LN19183 regulated the expression of markers of adipogenesis (PPAR-γ, C/EBPβ, SREBP-1, FABP4, FAS), lipolysis (ACYL, PPARα, CPT-1), and thermogenesis (PGC-1, UCP-1) by adiponectin, leptin, AMPK, and ACC. In vivo, LN19183 administration significantly reduced body weight, serum triglycerides, leptin, glucose and adipose weight. Our study was the first to reveal the anti-obesity effects of LN19183 through adipogenesis and lipolysis, supporting its potential as a nutraceutical for reducing body fat.
Antioxidant Properties of Mexican Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.
Bautista-Montero Z, Meneses ME, Martínez-Carrera D … +14 more , Sánchez-Tapia M, Hernández-Acosta J, Torres N, Bonilla M, Castillo I, Petlacalco B, Fernández N, Morales A, Martínez W, Coutiño-Hernández D, Aliphat M, Sánchez M, Tovar AR, Pérez-Herrera A
J Med Food · 2025 Nov · PMID 40833846 · Publisher ↗
Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom () contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and pre...
Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom () contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties. We assessed the effect of standardized -1 and -2 extracts (1%) consumed by obese C57BL/6 mice fed with a high-fat and sugar diet (HFSD), on weight increase, serum parameters, liver lipid accumulation, and the expression of antioxidant genes (glutathione peroxidase 1, catalase [CAT], superoxide dismutase [SOD] 1, SOD2) and proteins (CAT, SOD2, nuclear factor erythroid 2-related factor 2) in the liver. Fifty-six male C57BL/6 mice were randomized into seven groups involving the control and treatments during 17 weeks, as well as using metformin (Met, 250 mg/kg/day) as a reference drug. Serum lipids and glucose levels decreased in mice groups consuming extracts and metformin, in comparison with the HFSD group, as follows: total cholesterol (-11.8% to -35.7%), triglycerides (-8.3% to -24.8%), low-density lipoprotein cholesterol (-19.6% to -51.6%), and glucose (-3.1% to -25.7%). -1 and -2 extracts showed antioxidant properties and prevented lipid accumulation in the liver. The expression of antioxidant genes and proteins was significantly higher ( < .001) in the mice groups consuming extracts, as compared to the HFSD group. This evidence showed that -1 and -2 extracts prevented oxidative stress in the model of obesity induced by an HFSD.
Counteracted Severity Action of Juice on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats Through Inflammatory and Oxidative Stress Indicator Depletion.
Ayari A, Jedidi S, Arrari F … +2 more , Dakhli N, Sebai H
J Med Food · 2025 Oct · PMID 40831389 · Publisher ↗
Beetroot has been traditionally used in folk medicine to treat various gastrointestinal disorders and is commonly consumed for its high antioxidant content. The primary objective of this study is to demonstrate, for the...
Beetroot has been traditionally used in folk medicine to treat various gastrointestinal disorders and is commonly consumed for its high antioxidant content. The primary objective of this study is to demonstrate, for the first time, the potential therapeutic effects of beetroot juice (BJ) in a rat model suffering from ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). In addition, the study aims to identify the bioactive compounds in beetroot responsible for these effects. UC was induced in rats through the oral administration of DSS dissolved in drinking water (5%) during the final week of a 21-day treatment with BJ (5 and 10 mL/kg body weight) and compared to a reference drug, mesalazine. Phytochemical analysis revealed that BJ is a rich source of secondary metabolites such as polyphenols, flavonoids, soluble sugars, and betalains. The pretreatment with BJ significantly and dose-dependently reduced DSS-induced colonic mucosa lesions and associated histopathological alterations. The protective effects of BJ on the colonic mucosa were closely linked to its ability to mitigate oxidative damage, inflammatory injury, and biochemical imbalances. Specifically, BJ counteracted DSS-induced lipid peroxidation and restored levels of both enzymatic and nonenzymatic antioxidants. Moreover, BJ significantly decreased the levels of inflammatory markers and cytokines in plasma and colonic mucosa, while enhancing plasma scavenging activity and maintaining the homeostasis of intracellular mediators such as hydrogen peroxide, free iron, and ionizable calcium. These findings supported the use of BJ as a complementary approach for managing UC and underscore the need for further investigation into its potential clinical applications.
Heat-Modified Cornstarch by a Homemade Process with Glucose Extended-Release for Possible Dietary Treatment of Glycogen Storage Diseases.
Calderón de la Barca AM, Olivarría-Flores G, Cota-Ojeda AL … +1 more , Olivares-Sandoval IZ
J Med Food · 2025 Oct · PMID 40794520 · Publisher ↗
Glycogen storage diseases are genetic disorders involving glycogen storage or release. The cost of the modified starch (trademark Glycosade®) for treatment sometimes is not feasible, and patients are treated with oral un...
Glycogen storage diseases are genetic disorders involving glycogen storage or release. The cost of the modified starch (trademark Glycosade®) for treatment sometimes is not feasible, and patients are treated with oral uncooked cornstarch every 3 h. Our aim was to modify cornstarch at the lab and to translate it to a homemade process to extend glucose uptake for at least 5 h. We measured the transition phase of available cornstarch at low moisture. Then, cornstarch was heat-treated in a laboratory convection oven at 90, 95, and 100°C for 2 and 5 h and analyzed for hydrolysis and digestibility in comparison to Glycosade® by a cluster analysis. We replicated conditions in a kitchen roasting oven. A trial with 19 fasted healthy adults evaluated glucose after intake of 100 g/300 mL for 5 h. There were no phase transitions at 30% moisture, up to 100°C. At the lab, optimum conditions were 5 h at 90°C, with similar behavior to Glycosade®, and 95°C for 2 h in the kitchen roasting oven. The glucose levels of participants were maintained (106 to 95 mg/dL) along 5 h. In conclusion, euglycemia was prolonged at least 5 h after our product dosing as breakfast. The modified cornstarch could be prepared at home and used in patients with glycogen storage diseases, after clinical assessment.
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