Tohoku J. Exp. Med. [JOURNAL]

Hamartomas are abnormal tissue growths that can occur in various organs including the sinonasal tract. In this region, they are categorized into four subtypes, with respiratory epithelial adenomatoid hamartoma (REAH) bei... Hamartomas are abnormal tissue growths that can occur in various organs including the sinonasal tract. In this region, they are categorized into four subtypes, with respiratory epithelial adenomatoid hamartoma (REAH) being the most frequently reported. However, seromucinous hamartomas (SMHs) are rare, and only a limited number of case reports are available. This paper presents a case of an SMH located in the posterior nasal septum in a 45-year-old woman. The lesion was successfully excised in an outpatient procedure without complications. A pathological examination confirmed the diagnosis of SMH. At the three-month postoperative follow-up examination, no recurrence was observed and complete wound healing was noted, leading to the conclusion of follow-up. The continued accumulation of cases is needed to enhance the understanding of SMH, and it is important to recognize SMH as a potential differential diagnosis for tumorlike lesions in the sinonasal area. Although patient factors such as lesion location and comorbidities may influence treatment decisions, outpatient surgery can be a cost-effective option for SMHs when en bloc resection is feasible.

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HuangxueYishen Decoction Attenuates Chronic Kidney Disease: Associated with Inhibition of p38 MAPK Pathway Phosphorylation Activation.

Qian X, Chen Y, Zhou L … +4 more , Li X, Jin S, Zhao J, Lin S

Tohoku J Exp Med · 2026 Feb · PMID 41741143 · Publisher ↗

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Expression of Periostin in Congenital and Acquired Middle Ear Cholesteatoma.

Kitaya S, Ikeda R, Suzuki J … +12 more , Oshima H, Nomura Y, Kusano Y, Sato T, Kawase T, Ise K, Murakami K, Nakamura Y, Sasano H, Izuhara K, Ohta N, Katori Y

Tohoku J Exp Med · 2026 Feb · PMID 41708094 · Publisher ↗

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Targeting the METTL3-METTL14 Complex Alleviates Macrophage-Mediated Inflammation.

Zhou G, Wang B, Wang P … +11 more , Li Y, Ran X, Liu Y, Xu Y, Zheng L, Li C, Wang H, Liu S, Wu J, Zheng X, Zheng Y

Tohoku J Exp Med · 2026 Feb · PMID 41708093 · Publisher ↗

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Potential Treatment of Xuanyijing Prescription Against Dermatophytosis Caused by Trichophyton Rubrum.

Li Y, Xie J, Liao M

Tohoku J Exp Med · 2026 Feb · PMID 41708092 · Publisher ↗

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Autoantibodies and B Cells in Takayasu Arteritis and Giant Cell Arteritis: Comparative Insights into Large-Vessel Vasculitis.

Shirai T

Tohoku J Exp Med · 2026 Mar · PMID 41672504 · Publisher ↗

Large-vessel vasculitis (LVV) encompasses Takayasu arteritis (TAK) and giant cell arteritis (GCA), both characterized by granulomatous inflammation of large arteries. While these diseases have distinct clinical features,... Large-vessel vasculitis (LVV) encompasses Takayasu arteritis (TAK) and giant cell arteritis (GCA), both characterized by granulomatous inflammation of large arteries. While these diseases have distinct clinical features, the emergence of large-vessel GCA (LV-GCA) highlights an area of overlap with late-onset TAK. Although T cell- and macrophage-driven inflammation represents a shared hallmark, the contribution of B cells and autoantibodies remains less clearly defined. This review comparatively summarizes B cell mediated responses and autoantibody involvement in TAK and GCA. TAK demonstrates significant B cell activity, evidenced by B cell infiltration and the presence of tertiary lymphoid organs (TLOs) within the arterial wall. Importantly, specific autoantibodies, such as anti-endothelial protein C receptor (EPCR) and anti-scavenger receptor class B type I antibodies, have been identified. Anti-EPCR antibodies specifically associate TAK with coexisting ulcerative colitis, suggesting a shared aberrant immune pathway. In contrast, cranial GCA is primarily T cell-driven and contains relatively few B cells. However, aortic lesions in LV-GCA exhibit extensive B cell and plasma cell infiltration, including TLOs, indicating that this subtype shares key B cell mediated responses with TAK. Despite this immunological convergence, the specific autoantibody profiles appear distinct and remain incompletely characterized. Taken together, B cell and autoantibody responses are more pronounced and functionally relevant in TAK, show intermediate involvement in LV-GCA, and are least prominent in cranial GCA. These differences provide critical insights for LVV subtyping and underscore the need for further elucidation of the pathomechanisms underlying TAK, late-onset TAK, LV-GCA, and cranial GCA to enable personalized therapeutic strategies.

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