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Tohoku J. Exp. Med. [JOURNAL]

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Adipose-derived Mesenchymal Stem Cells-Derived Exosomes Alleviate LPS-Induced Hepatocyte Injury in Sepsis by Inhibiting the JAK2/STAT3 Signaling Pathway.

Yi X, Lin T, Shen X … +6 more , Liu B, Mao H, Zheng M, Zhou F, Ding Y, Jin Y

Tohoku J Exp Med · 2026 Jun · PMID 41638672 · Publisher ↗

The severity of sepsis-induced hepatic injury severely impacts disease progression and prognosis. Hence, this study investigates the role of adipose-derived mesenchymal stem cells (ADSCs)-derived exosomes (ADSCs-exo) in... The severity of sepsis-induced hepatic injury severely impacts disease progression and prognosis. Hence, this study investigates the role of adipose-derived mesenchymal stem cells (ADSCs)-derived exosomes (ADSCs-exo) in mitigating hepatic injury during sepsis. An in vitro model of sepsis-induced hepatic injury was established by stimulating HepG2 cells with lipopolysaccharide (LPS). ADSCs were either co-cultured with LPS-injured HepG2 cells or used to isolate exosomes for subsequent treatment. The characteristics of ADSCs-derived exosomes were identified using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blot. ADSCs-exo uptake by hepatocytes was assessed via PKH67 labeling. Cell viability, apoptosis, and lactate dehydrogenase (LDH) release were evaluated using Cell Counting Kit-8, flow cytometry, and commercial assays, respectively. The involvement of the janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was further investigated. Both ADSCs and ADSCs-exo notably attenuated LPS-induced hepatocyte injury, as evidenced by lowered LDH release, enhanced cell viability, and suppressed apoptosis. ADSCs-exo were internalized by HepG2 cells. Treatment with ADSCs-exo led to a notable downregulation of phosphorylated JAK2 and STAT3. Moreover, pharmacological activation of the JAK2/STAT3 pathway partially reversed the protective effects of ADSCs-exo. Collectively, ADSCs-exo alleviate LPS-induced hepatocyte injury by inhibiting activation of the JAK2/STAT3 signaling pathway. These findings underscore the potential of ADSCs-exo as a promising cell-free therapeutic strategy for sepsis-associated liver injury.

Transcription Factor 21 Inhibits Prostate Cancer Progression via Transcriptional Repression of PSAT1.

Wang S, Wang Q, Wang Y … +1 more , Shao X

Tohoku J Exp Med · 2026 Feb · PMID 41638670 · Publisher ↗

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TAL1 Suppresses High-Grade Serous Ovarian Cancer Progression by Transcriptionally Inhibiting TPI1-Mediated Glycolysis.

Zhao N, Wang Y, Gao W … +1 more , Zhou C

Tohoku J Exp Med · 2026 Feb · PMID 41638669 · Publisher ↗

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Erythropoietin Hydrogel Combined with Open Decompression is Effective in Treating the Rabbit Model of Osteofascial Compartment Syndrome after a Deinagkistrodon Acutus Bite.

Zhang W, He H, Zhu J … +1 more , Yang F

Tohoku J Exp Med · 2026 Jan · PMID 41605674 · Publisher ↗

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Targeting Cystatin SN Inactivates AKT Pathway to Decrease Cell Proliferation, Migration, and Invasion in Thyroid Cancer.

Li Y, Liu Z, Wan J

Tohoku J Exp Med · 2026 Jan · PMID 41605673 · Publisher ↗

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DLGAP1-AS1 Promotes the Progression of Esophageal Squamous Cell Carcinoma via the miR-628-5p/TMEM33/Notch Pathway.

Li Y, Yu H, Wang J … +1 more , Kang K

Tohoku J Exp Med · 2026 Jan · PMID 41605672 · Publisher ↗

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miR-103-3p Delivered by Circulating Extracellular Vesicles Contributes to Anesthesia/Surgery-Induced Postoperative Delirium-Like Behaviors and Neuroinflammation in Aged Mice.

Li Y, Yan X, Guo Y … +2 more , Ren X, Zhou X

Tohoku J Exp Med · 2026 Jan · PMID 41565267 · Publisher ↗

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From Carbonic Anhydrase 12 to TGFβ1/Smad Pathway: A Key Mechanism for Isoorientin in Pulmonary Fibrosis Therapy.

Xue T, Liang F, Ding Z

Tohoku J Exp Med · 2026 Jan · PMID 41565266 · Publisher ↗

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Roles and Therapeutic Application of Vasohibin-2 in Cancers.

Suzuki Y, Sato Y

Tohoku J Exp Med · 2026 Jan · PMID 41565265 · Publisher ↗

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Concurrent Thyroid Tumor in an Elderly Patient with Giant Cell Arteritis: A Case Report.

Migita K, Yamane H, Ifuku K … +7 more , Mori F, Yamasaki K, Yoshida S, Matsumoto H, Kawakami A, Otsubo R, Isomoto I

Tohoku J Exp Med · 2026 Jan · PMID 41565264 · Publisher ↗

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Associations of Psychological Distress with Esophageal Functional Metrics in Patients with Refractory Reflux-Like Symptoms: A Retrospective Study.

Lou L, Huang Y, Chen D … +4 more , Mo G, Yang W, Song G, Yang J

Tohoku J Exp Med · 2026 Mar · PMID 41535011 · Publisher ↗

The primary objective of this study was to investigate the established correlations between psychological factors (anxiety, depression, and sleep quality) and esophageal physiological parameters. Additionally, this resea... The primary objective of this study was to investigate the established correlations between psychological factors (anxiety, depression, and sleep quality) and esophageal physiological parameters. Additionally, this research aimed to examine the distribution patterns of these psychological factors across distinct subgroups of GERD symptom presentations. Retrospective analysis included 75 patients aged 18-70 with persistent reflux symptoms despite 8 weeks of proton pump inhibitor (PPI) therapy. Evaluations included esophagogastroduodenoscopy, high-resolution manometry, 24-hour pH-impedance monitoring, and psychological assessments (SAS, SDS, PSQI). Patients were grouped into refractory gastro-esophageal reflux disease (rGERD), functional heartburn (FH), and reflux hypersensitivity (RH). MNBI, PSPW-I, and EGJ-CI were compared, and correlations with psychological and sleep parameters were analyzed. Distal MNBI was significantly lower in rGERD (1177.91 ± 707.22 Ω) vs. FH (1995.77 ± 476.02 Ω) and RH (2062.35 ± 509.93 Ω) (P < 0.001). Anxiety prevalence was 85.7% in rGERD, 64.7% in FH, and 67.5% in RH (P = 0.302); depression affected 78.6% of rGERD, 70.8% of FH, and 72.9% of RH patients (P = 0.942). Poor sleep quality was present in > 80% of all groups. PSPW-I negatively correlated with anxiety (r = -0.181, P < 0.05) and depression (r = -0.158, P < 0.05), as did proximal MNBI with depression (r = -0.175, P < 0.05). A distal MNBI cutoff of 1531 Ω distinguished rGERD from FH/RH with 71.4% sensitivity and 87.5% specificity (AUC = 0.80). Anxiety, depression and poor sleep quality may reduce the efficacy of PPI. Distal MNBI effectively differentiates rGERD from FH/RH.

Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.

Li B, Kumada K, Shimada M … +29 more , Shirota H, Tokunaga H, Yamaguchi-Tanaka M, Inoue C, Yamazaki Y, Yamamura A, Furukawa T, Komine K, Ogishima S, Tamahara T, Saito S, Shimizu R, Iikubo M, Yamauchi K, Saito T, Fujimaki SI, Abe Y, Nakamura N, Ota H, Nagami F, Kinoshita K, Nakazawa T, Motohashi H, Ishii N, Ishioka C, Harigae H, Tominaga T, Yaegashi N, Yamamoto M

Tohoku J Exp Med · 2026 Jan · PMID 41535009 · Publisher ↗

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Role of MALAT1 in the Progression of ACLF via the miR-141-3p/TGFB2 Axis and Its Association with Patient Prognosis.

Qiao Y, Wu D, Jiang H … +2 more , Li Y, Zhang D

Tohoku J Exp Med · 2026 Jan · PMID 41535008 · Publisher ↗

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Clinical Diagnostic Value of miR-142-3p in Pediatric Acute Respiratory Distress Syndromes and Its Effects on Human Lung Epithelial Cells.

Yan W, He J, Zhou Y … +1 more , Zhu J

Tohoku J Exp Med · 2026 Jan · PMID 41535007 · Publisher ↗

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Embelin Ameliorates DSS-Induced Ulcerative Colitis by Concurrent Inhibition of TREM-1 and PI3K/AKT Signaling Pathways.

Yu J, Liu Z, Li J … +2 more , You L, Huang Y

Tohoku J Exp Med · 2026 Jan · PMID 41500610 · Publisher ↗

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HSPA1B Overexpression Induces Benign Prostatic Hyperplasia Through Enhancing Endoplasmic Reticulum Stress to Promote NLRP3 Inflammasomes-Mediated Pyroptosis.

Yu X, Tan H, Gao Y … +3 more , Wang S, Qiu D, Zhu Y

Tohoku J Exp Med · 2026 Jan · PMID 41500609 · Publisher ↗

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Ginsenoside Rd Ameliorates Doxorubicin-Induced Cardiomyocyte Injury by Regulating the MIR100HG/miR-498/SMURF2 Axis in vitro.

Zhang Q, Liu T, Yu X … +7 more , Liu B, Zou Y, Yin J, Wang L, Liu B, Huang L, Dai R

Tohoku J Exp Med · 2026 Jan · PMID 41500608 · Publisher ↗

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