Tohoku J. Exp. Med. [JOURNAL]

Tinnitus is a common disorder that influences the quality of life. This study aimed to investigate its neurological underpinnings by employing resting-state functional magnetic resonance imaging (rs-fMRI). Fifty-eight pa... Tinnitus is a common disorder that influences the quality of life. This study aimed to investigate its neurological underpinnings by employing resting-state functional magnetic resonance imaging (rs-fMRI). Fifty-eight patients with tinnitus and 52 healthy controls (HCs) were enrolled and underwent rs-fMRI. The fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and seed-based functional connectivity (FC) were used to detect disparities in the brains of the two groups. Comparison analyses were adjusted by family wise error (FWE) correction. Compared with HCs, patients with tinnitus showed decreased fALFF levels in left middle temporal gyrus (MTG.L) (P = 0.053) and the left middle occipital gyrus (MOG.L) (P = 0.073), as well as a reduced ReHo level in right fusiform gyrus (FFG.R) (P = 0.049, P = 0.735). Moreover, patients with tinnitus had lower FC in MTG.L with left thalamus (THA.L) (P = 0.052, P = 0.395) and right thalamus (THA.R) (P = 0.012, P = 0.107), reduced FC between MOG.L and left dorsolateral superior frontal gyrus (SFGdor.L) (P = 0.003), and decreased FC between FFG.R and the right middle frontal gyrus (P = 0.1). Receiver operating characteristic curve analyses showed that MTG.L (fALFF), MOG.L (fALFF), FFG.R (ReHo), FC between MTG.L and THA.L, FC between MTG.L and THA.R, and FC between MOG.L and SFGdor.L, all showed acceptable ability to discriminate patients with tinnitus and HCs, with most of the area under the curves greater than 0.7. In conclusion, patients with tinnitus show notable disturbances in neural activity in non-auditory brain areas, specifically in the prefrontal cortex.

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NPSR1-AS1 Promotes Colorectal Cancer Cell Proliferation by Upregulating YRDC Expression via Interaction with miR-365b-3p.

Li G, Wang Y, Lu Y … +4 more , Chen W, Kang X, Han Z, Liu M

Tohoku J Exp Med · 2025 Dec · PMID 41443889 · Publisher ↗

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miR-142-3p as A Biomarker for Diagnosis and Prognosis of Acute Ischemic Stroke and Its Association with the Inflammation and Severity.

Zhang Y, Tong Z, Wang Y … +3 more , Guo Z, Li W, Huang Y

Tohoku J Exp Med · 2025 Dec · PMID 41443888 · Publisher ↗

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Matrine Inhibits Proliferation and Migration of Esophageal Cancer Cells by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.

Liu B, Wu P, Li X … +2 more , Liu F, Lv Y

Tohoku J Exp Med · 2025 Dec · PMID 41407357 · Publisher ↗

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Three-Month Functional Exercise Reduces Upper Limb Lymphedema After Breast Cancer Surgery: A Prospective Randomized Controlled Trial.

Hu M, Yang L, Han J … +4 more , Zhu W, Yang S, Wang X, Chen X

Tohoku J Exp Med · 2025 Dec · PMID 41371689 · Publisher ↗

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Avoiding Open-Skull Biopsy in Osteomyelitis-Pachymeningitis with Severe Recurrent Temporal Swelling: An Experience of SAPHO syndrome with Increased Serum IgG4 and Its Literature Review.

Sakaji K, Shijo T, Umezawa S … +4 more , Ono H, Fujino H, Misu T, Aoki M

Tohoku J Exp Med · 2025 Dec · PMID 41371688 · Publisher ↗

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Aberrant Expression of lncRNA TTC28-AS1/miR-767-5p in Allergic Rhinitis and Its Potential Effect on the Disease Progression.

Kan D, Ran L, Yu Y … +4 more , Huang Y, Lou G, Wu J, Pan Y

Tohoku J Exp Med · 2025 Dec · PMID 41371687 · Publisher ↗

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Verification of Causal Relationships Between Nurses' Job Satisfaction and Intention to Leave: A Three-Wave Longitudinal Panel Study in Japan.

Takahashi M, Asakura K, Takada N … +2 more , Sugiyama S, Hara Y

Tohoku J Exp Med · 2025 Dec · PMID 41338967 · Publisher ↗

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Capillary Leak Syndrome and Inflammatory Bowel Diseases Like-Symptoms in Leigh Syndrome.

Numata-Uematsu Y, Shibuya M, Katata Y … +6 more , Oikawa Y, Takezawa Y, Murayama K, Ohtake A, Kikuchi A, Uematsu M

Tohoku J Exp Med · 2025 Dec · PMID 41338966 · Publisher ↗

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The Validation of the Effectiveness of Guidelines and the New Reimbursement Scheme for the Prevention of Secondary Hip Fractures in Japan - Current Status of Examination and Medication for Inpatients with Hip Fracture.

Abe K, Tarasawa K, Kato D … +2 more , Fushimi K, Fujimori K

Tohoku J Exp Med · 2025 Dec · PMID 41338965 · Publisher ↗

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Artificial Intelligence for Breast Carcinoma Detection in Histopathological Images Based on Single Shot Multibox Detector in Intraoperative Rapid Diagnosis.

Yamaguchi-Tanaka M, Sasaki T, Uemura K … +8 more , Tajima Y, Kato S, Asakura T, Takagi K, Yamazaki Y, Masamune A, Miyata T, Suzuki T

Tohoku J Exp Med · 2025 Dec · PMID 41338964 · Publisher ↗

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Surgical Outcomes of Patients Undergoing Ureteroscopic Holmium Laser Lithotripsy and Patient Satisfaction after Implementation of An Enhanced Recovery after Surgery Protocols.

Peng Y, Rao M, Zhu J

Tohoku J Exp Med · 2025 Nov · PMID 41297943 · Publisher ↗

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Association of TMEM106B Gene rs1990622 Polymorphism with Cognitive Impairment in Adolescents with Depressive Disorder.

Zhang C, Deng K

Tohoku J Exp Med · 2026 Jan · PMID 41297942 · Publisher ↗

Genetic variations may serve as a critical factor in depressive cognitive impairment development. The study aimed to investigate the association between the TMEM106B gene rs1990622 polymorphism and cognitive impairment i... Genetic variations may serve as a critical factor in depressive cognitive impairment development. The study aimed to investigate the association between the TMEM106B gene rs1990622 polymorphism and cognitive impairment in individuals with depression. A total of 700 participants were enrolled in this study, comprising 350 adolescent depression patients without cognitive impairment (control group) and 350 adolescent depression patients with cognitive impairment (cognitive impairment group). Depressive symptom severity was evaluated with the Hamilton Depression Rating Scale (HAMD-17), and cognitive dysfunction was screened using the Montreal Cognitive Assessment-Beijing version (MoCA-BJ). Genotyping of TMEM106B rs1990622 was performed using the Sanger sequencing method, while the expression of TMEM106B was measured by RT-qPCR. Logistic regression identified risk factors for cognitive impairment in adolescent depression. Individuals carrying the GA (P = 0.014, OR = 1.568, 95% CI:1.093-2.251) and AA (P < 0.001, OR = 2.455, 95% CI:1.630-3.699) genotype at the TMEM106B rs1990622 locus exhibited an increased risk of cognitive impairment, suggesting that the A allele may serve as a risk factor for cognitive impairment in this population (P < 0.001, OR = 1.629, 95% CI:1.319-2.012). Depression patients with the AA genotype demonstrated the poorest cognitive performance. Furthermore, the expression level of the TMEM106B gene was significantly higher in the cognitive impairment group. Educational attainment, the GA and AA genotypes at rs1990622, and TMEM106B expression levels were identified as independent risk factors for depressive cognitive impairment. The TMEM106B rs1990622 variant may significantly impact cognitive impairment in depression patients.

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Solitary Lymph Node Metastasis of Sigmoid Colon Cancer to Posterior Site of Inferior Vena Cava: A Case Report.

Sai Y, Saito R, Sato M … +12 more , Takido N, Okada K, Inoue C, Ogasawara H, Shono Y, Matsumura M, Sasaki K, Fujio A, Tokodai K, Ohnuma S, Unno M, Kamei T

Tohoku J Exp Med · 2025 Nov · PMID 41260703 · Publisher ↗

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Work Conditions Leading to Job Retention among individuals with Neurodevelopmental Disorders.

Yoshida T, Mashiko H, Ohira T

Tohoku J Exp Med · 2025 Nov · PMID 41260702 · Publisher ↗

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Curdione Suppresses Non-Small Cell Lung Cancer Growth by Inducing Ferroptosis.

Che Z, Yao Y, Zhang S

Tohoku J Exp Med · 2025 Nov · PMID 41224330 · Publisher ↗

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Tohoku J. Exp. Med. [JOURNAL]

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