J Cancer Res Ther [JOURNAL]
Sun
200 papers
Paraneoplastic syndromes in ovarian cancer: Clinical manifestations, mechanisms and management challenges.
Ray MD, Halder S, Kapoor R
J Cancer Res Ther · 2025 Oct · PMID 41474560 · Publisher ↗
Paraneoplastic syndromes encompass an enigmatic spectrum of clinical manifestations precipitated by various malignancies but not attributable to direct tumor invasion, metastatic dissemination, or hormone secretion from...
Paraneoplastic syndromes encompass an enigmatic spectrum of clinical manifestations precipitated by various malignancies but not attributable to direct tumor invasion, metastatic dissemination, or hormone secretion from the affected organ. In ovarian cancer, a notably heterogeneous malignancy with a predilection for presentation at the advanced stage, paraneoplastic manifestations may arise from multiple organ systems, thereby complicating diagnosis, altering clinical trajectories, and exerting profound impact on both short- and long-term patient outcomes. These phenomena, observed across both epithelial and nonepithelial ovarian tumors, are often mediated through immune cross-reactivity, ectopic hormone secretion, or cytokine dysregulation. Notable manifestations include neurological syndromes, such as cerebellar degeneration, anti-N-methyl-D-aspartate receptor encephalitis, and metabolic disturbances like hypercalcemia, Cushing's syndrome, and thromboembolic states. Despite significant advancements, the diverse clinical presentations of paraneoplastic syndromes continue to pose substantial diagnostic ambiguities, with challenges in surgical planning and operative intricacies. This narrative review aims to elucidate an expansive analysis of the extant data on epidemiological patterns of ovarian cancer-associated paraneoplastic syndromes, their underlying molecular and immunological drivers, and management strategies. The review utilized extensive search across PubMed, EMBASE, Medline, Scopus, and Cochrane Library databases from January 2000 to March 2024. Inclusion criteria included peer-reviewed studies reporting ovarian cancer patients with clinically confirmed paraneoplastic syndromes, definite investigations, and clinical outcomes. Furthermore, it emphasizes the critical importance of multidisciplinary approaches to deliver holistic perioperative care, while addressing the systemic perturbations induced by paraneoplastic processes.
AI-driven precision in prostate brachytherapy: A systematic review of 70 studies.
Pareek V, Dube S, Patil N … +3 more , Johnny C, Mutua F, Bashir B
J Cancer Res Ther · 2025 Oct · PMID 41474559 · Publisher ↗
Artificial intelligence (AI) has transformed prostate brachytherapy by enhancing precision, efficiency, and personalization. This systematic review evaluates 70 peer-reviewed studies from PubMed, Embase, and Web of Scien...
Artificial intelligence (AI) has transformed prostate brachytherapy by enhancing precision, efficiency, and personalization. This systematic review evaluates 70 peer-reviewed studies from PubMed, Embase, and Web of Science, focusing on the applications of AI in imaging, treatment planning, applicator reconstruction, and outcome prediction. Machine learning (ML) and deep learning (DL) techniques, including U-Net and deep reinforcement learning, demonstrate improvements in segmentation (84% sensitivity), dose optimization (20-30% time savings), and quality assurance (25% error reduction). Challenges include limited dataset diversity, generalizability, and clinical integration. This review highlights AI's potential to revolutionize prostate brachytherapy and identifies research gaps necessary for its clinical adoption.
Genetic susceptibility to retinoblastoma: A meta-analysis of single-nucleotide polymorphisms across global populations.
Gupta S, Das D, Nandyala S … +2 more , Roy TK, Tiwari U
J Cancer Res Ther · 2025 Oct · PMID 41474558 · Publisher ↗
The effect of single-nucleotide polymorphisms (SNPs) in Cyclin Dependent Kinase Inhibitor 1A (CDKN1A C/A), Mouse Double Minute 2 (MDM2), 309 T/G methylenetetrahydrofolate reductase (MTHFR) 677 C/T, MTHFR 1298 A/C, and Me...
The effect of single-nucleotide polymorphisms (SNPs) in Cyclin Dependent Kinase Inhibitor 1A (CDKN1A C/A), Mouse Double Minute 2 (MDM2), 309 T/G methylenetetrahydrofolate reductase (MTHFR) 677 C/T, MTHFR 1298 A/C, and Methionine synthase (MTR) 2756 A/G has been investigated in retinoblastoma (RB) with inconsistent results. Therefore, this study aims to conduct a meta-analysis and explore the overall role of these genetic variants with retinoblastoma risk. Literature search was done using PubMed, EMBASE, Cochrane Library, Google, Dogpile, and CBM all studies evaluating the association between CDKN1A or p21 C/A, MDM2 309 T/G, MTHFR 677 C/T, MTHFR 1298 A/C, and MTR 2756 A/G polymorphism and RB risk were included. A total of 1773 patients and 2474 controls were included. To understand these polymorphisms' role in RB risk, pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random or fixed effects model. P values < 0.05 were considered statistically significant. Funnel plots were used to assess publication bias. Our meta-analysis showed a significant association between RB susceptibility to CDKN1A dominant model (OR = 1.518, 95% CI = 1.003-2.298, P = 0.048), MDM2 dominant model (OR = 0.700, 95% CI = 0.542-0.903, P = 0.006) and MTR 2756 A/G all models that is allele model (OR = 4.680, 95% CI = 1.992-10.993, P = 0.000), dominant model (OR = 2.044, 95% CI = 1.511-2.765, P = 0.000), and recessive model (OR = 0.283, 95% CI = 0.122-0.656, P = 0.003). The present meta-analysis suggested that MTR 2756 A/G, MDM2 309 T/G, and CDKN1A polymorphism are associated with the risk of RB.
Reconsidering evidence-based oncology: The need for clinical judgment and contextualized care.
Waghmare CSM
J Cancer Res Ther · 2025 Oct · PMID 41474557 · Publisher ↗
Abstract loading — click title to view on PubMed.
Erratum: Efficacy and safety of the CT-guided co-ablation system in the treatment of malignant melanoma with hepatic metastasis.
J Cancer Res Ther · 2025 Dec · PMID 41474253 · Publisher ↗
Abstract loading — click title to view on PubMed.
Rare recurrent multiple pulmonary sclerosing pneumocytoma with sarcomatoid features: A case report and literature review.
Jiang N, Cheng H, Li J … +1 more , Sun Q
J Cancer Res Ther · 2025 Dec · PMID 41474252 · Publisher ↗
Pulmonary sclerosing pneumocytoma (PSP) is a rare pulmonary tumor of pneumocytic origin, traditionally considered benign and associated with a favorable prognosis. However, accumulating evidence suggests that PSP may exh...
Pulmonary sclerosing pneumocytoma (PSP) is a rare pulmonary tumor of pneumocytic origin, traditionally considered benign and associated with a favorable prognosis. However, accumulating evidence suggests that PSP may exhibit potentially malignant behavior and marked histopathological heterogeneity, which can complicate accurate diagnosis. These features often create diagnostic challenges during preoperative biopsy, intraoperative frozen section analysis, and postoperative histopathological evaluation. Herein, we report a rare case of recurrent, multifocal PSP exhibiting sarcomatoid features and harboring a p.E17K mutation in the AKT1 gene.
Microwave ablation combined with transarterial embolization for retroperitoneal inflammatory myofibroblastic tumor: A case report on complete response.
Zhou C, Chen S, Shen L … +8 more , Qi H, Cao F, Huang T, Xie L, Tan H, Wen C, Wang Y, Fan WJ
J Cancer Res Ther · 2025 Dec · PMID 41474251 · Publisher ↗
Inflammatory myofibroblastoma tumor (IMT) is rare neoplasm that has high recurrence rate and low likelihood of metastasis. Here, we report the efficacy and safety of microwave ablation (MWA) combined with transarterial e...
Inflammatory myofibroblastoma tumor (IMT) is rare neoplasm that has high recurrence rate and low likelihood of metastasis. Here, we report the efficacy and safety of microwave ablation (MWA) combined with transarterial embolization in a patient with unresectable retroperitoneal IMT measuring 89 mm in maximum diameter. Multiple courses of MWA, the last of which was performed under magnetic resonance imaging guidance, and one course of transarterial embolization resulted in complete response without complications. After more than 1.5 years of the last MWA treatment, follow-up showed sustained complete response. This case suggested that the combination of MWA and transarterial embolization is a new option for retroperitoneal IMT. A multicenter and large-sample clinical trial is required to confirm the efficacy and safety of MWA combined with transarterial embolization for retroperitoneal IMT.
CT radiomics-based cluster analysis for predicting invasiveness of stage I lung adenocarcinoma.
Yao T, Jia H, Wei Z … +1 more , Li C
J Cancer Res Ther · 2025 Dec · PMID 41474250 · Publisher ↗
OBJECTIVE: To explore a noninvasive predicting model for identifying patients with stage I lung invasive adenocarcinoma (IAC). METHODS: This study enrolled 289 patients from two medical centers, with 227 and 62 patients...
OBJECTIVE: To explore a noninvasive predicting model for identifying patients with stage I lung invasive adenocarcinoma (IAC). METHODS: This study enrolled 289 patients from two medical centers, with 227 and 62 patients in the training and validation sets, respectively. Patients' chest computed tomography (CT) images were used. The K-means cluster algorithm was employed to group patients into new clusters based on radiomics features. In addition, logistic regression was used to develop prediction models. Diagnostic efficiency was assessed using the area under the receiver operating characteristic curve, along with calibration and decision curve analysis. RESULTS: The K-means cluster algorithm classified patients into cluster 1 (training: 143; validation: 35) and cluster 2 (training: 84; validation: 27). Cluster 2 had a higher proportion of patients with IAC. The optimal model incorporating tumor diameter, tumor type, and cluster labels achieved the best discriminatory performance, with area under the receiver operating characteristic curve values of 0.848 (95% confidence interval: 0.799-0.898) in the training set and 0.744 (95% confidence interval: 0.583-0.905) in the validation set. CONCLUSION: This study proposes a radiomics model that accurately identifies patients with IAC. This prediction tool could aid in personalized risk classification and treatment planning.
The value of reconstruction methods of enhanced computed tomography (CT) images for the assessment of cardiac structural dose in patients undergoing radiotherapy for breast cancer.
Xue B, Song T, Fan X … +2 more , Liu Y, Li L
J Cancer Res Ther · 2025 Dec · PMID 41474249 · Publisher ↗
OBJECTIVE: To explore the evaluation value of different reconstruction methods of enhanced computed tomography (CT) images on the cardiac structure dose in patients undergoing radiotherapy for breast cancer. METHODS: A r...
OBJECTIVE: To explore the evaluation value of different reconstruction methods of enhanced computed tomography (CT) images on the cardiac structure dose in patients undergoing radiotherapy for breast cancer. METHODS: A retrospective analysis of the cardiac structure data of 200 female patients with left-sided breast cancer, who underwent enhanced CT scans was conducted. Image reconstruction was performed with a time interval of 5% of the cardiac cycle (0%-95%), obtaining maximum intensity projection (MIP), minimum intensity projection (MinIP), and average intensity projection (AIP) images. The left ventricle (LV) and the left anterior descending artery (LAD) were delineated on the four types of images. RESULTS: The MinIP, MIP, and AIP images showed larger LAD volumes than enhanced CT images (P < 0.05). Compared with the dose sum, the changes in V5Gy, V30Gy, V40Gy, Dmax, and Dmean for LV on MIP images were all <5% (4.02%, 2.17%, 1.39%, 2.99%, and 1.93%, respectively). The Dmax and Dmean change rates for LV on MinIP images were both <5%, at 2.00% and 4.73%, respectively; the Dmax and Dmean change rates for LV on AIP images were also both <5%, at 3.01% and 3.99%. Compared with the dose sum, only the Dmax change rates for LAD on MIP, MinIP, and AIP images were <5% (all P > 0.05), at 4.96%, 4.01%, and 4.07%, respectively. CONCLUSION: In LV dose-volume assessment, the differences in assessment metrics between MIP images and enhanced CT images are small, indicating that MIP imaging can serve as a supplementary method to enhanced CT imaging for this form of assessment.
Body composition in CT as a predictor of major post-operative complications in patients undergoing definitive surgery for intestinal fistulas.
Wang Y, Li J, Wen P … +2 more , Wang L, Zheng Z
J Cancer Res Ther · 2025 Dec · PMID 41474248 · Publisher ↗
BACKGROUND: Managing intestinal fistulas is complex and challenging due to the development of postoperative complications. It is essential to evaluate the effects of computed tomography (CT) body composition imaging biom...
BACKGROUND: Managing intestinal fistulas is complex and challenging due to the development of postoperative complications. It is essential to evaluate the effects of computed tomography (CT) body composition imaging biomarkers on major postoperative complications in these patients following definitive surgery. METHODS: A total of 88 patients with intestinal fistula, who underwent definitive surgery were retrospectively reviewed. Each body composition index was calculated by dividing the cross-sectional area of the adipose or muscle tissue at the level of the third lumbar vertebra, as identified on a preoperative CT scan, by the square of the height. Postoperative complications were scored according to the Clavien-Dindo classification. RESULTS: Sixteen out of the 88 patients (18.08%) had major postoperative complications. In the univariate analysis, lower quadratus lumborum index (QLI; P = 0.047) and quadratus lumborum areas ([QLA]/body mass index [BMI]; P = 0.023), higher C-reactive protein (CRP; P = 0.036), longer length of stay (LOS; P = 0.002), and fewer preoperative admission histories (P = 0.049), were identified as risk factors. In the multivariable regression analysis, QLI (P = 0.011; odds ratio [OR] = 0.383) and LOS (P = 0.012; OR = 1.006) were identified as independent risk factors for major postoperative complications. Furthermore, QLI, QLA/BMI, CRP, LOS, sex, and age showed the highest area under the curve of 0.815, with a specificity and sensitivity of 64.8% and 93.8%, respectively (P < 0.001). CONCLUSION: Patients with lower QLI and QLA/BMI, longer LOS, and higher CRP were prone to have major postoperative complications.
CT-based delta-radiomics nomogram for predicting post-neoadjuvant chemoradiotherapy lymph node metastasis in esophageal squamous cell carcinoma: A feasibility study.
Zhang B, Yi Y, Kong L … +4 more , Li S, Fu C, Cao Q, Li B
J Cancer Res Ther · 2025 Dec · PMID 41474247 · Publisher ↗
BACKGROUND: This study developed a nomogram using computed tomography (CT)-based delta-radiomics features and clinicopathological factors to predict lymph node metastasis (LNM) in patients with esophageal squamous cell c...
BACKGROUND: This study developed a nomogram using computed tomography (CT)-based delta-radiomics features and clinicopathological factors to predict lymph node metastasis (LNM) in patients with esophageal squamous cell carcinoma (ESCC) receiving neoadjuvant chemoradiotherapy (nCRT). METHODS: This study retrospectively enrolled 170 patients with ESCC receiving nCRT. The delta-radiomics signature model was constructed utilizing least absolute shrinkage and selection operator regression, and the radiomics score (radScore) was determined for each patient. A combined nomogram was established using the radScore and independent influencing factors obtained through univariate and multivariate analyses. The consistency and predictive ability of the nomogram were assessed using the calibration curve and the area under the receiver operating factor curve (AUC). The clinical benefits were assessed using decision curve analysis (DCA). RESULTS: Two predictive models were constructed. The AUC values for the delta-radiomics signature model were 0.881 [95% confidence interval (CI): 0.827-0.935]. According to the univariate and multivariate analyses, the tumor length, tumor differentiation, and radScore were independent factors influencing LNM (P < 0.05). A combined nomogram was constructed from these factors, and the AUC reached 0.938 (95% CI: 0.898-0.979). DCA demonstrated that the clinical benefits of the nomogram for patients across an extensive range were more significant than the radiomics model alone. CONCLUSIONS: This CT-based delta-radiomics nomogram model could benefit LNM in patients with ESCC following nCRT.
Construction of nomograms for survival prediction in high-grade chondrosarcoma based on multivariable analysis: A SEER database study.
Fan X, Li C, Ge H … +3 more , Zhao BA, Yuan Y, Cheng B
J Cancer Res Ther · 2025 Dec · PMID 41474246 · Publisher ↗
BACKGROUND: Chondrosarcoma is the second most common malignant primary bone tumor. Given the poorer prognosis of high-grade chondrosarcomas and the lack of prognostic tools, this study aimed to develop a nomogram for bet...
BACKGROUND: Chondrosarcoma is the second most common malignant primary bone tumor. Given the poorer prognosis of high-grade chondrosarcomas and the lack of prognostic tools, this study aimed to develop a nomogram for better prognosis evaluation. METHODS: A comprehensive approach was adopted, involving Kaplan-Meier analysis for survival curve generation, log-rank test for comparing survival differences, and multivariate Cox regression analysis for identifying independent prognostic determinants. Utilizing the "rms" package, nomograms were constructed to predict overall survival (OS) and cancer-specific survival (CSS) of patients with high-grade chondrosarcoma. Nomogram reliability was validated through the concordance index (C-index) and calibration curves, which quantitatively and graphically evaluated the predictive accuracy. RESULTS: A total of 1,198 high-grade chondrosarcoma cases retrieved from the SEER database were retrospectively analyzed. Following Kaplan-Meier survival analysis, several variables (age, sex, tumor size, stage, metastasis, surgery, chemotherapy, and radiation for OS) were incorporated into the multivariate Cox regression models for OS and CSS. Nomograms for OS and CSS were established based on the derived independent prognostic factors. The C-indices of the training and validation cohorts were 0.8117 and 0.7642 for the OS and 0.8475 and 0.8173 for the CSS analysis, respectively. The calibration plots further corroborated the nomograms' accurate predictive capacity for both OS and CSS. CONCLUSION: Nomograms capable of precisely estimating OS and CSS in high-grade chondrosarcoma were successfully developed. These nomograms offer clinicians a valuable tool for more accurate survival prediction of patients with high-risk chondrosarcoma, which optimizes postoperative treatment strategies and improves patient management and outcomes.
Comparative diagnostic efficacy of 18F-FDG and FAPI PET/CT in primary liver cancers: A systematic review and meta-analysis.
Wang H, Wang J, Li G
J Cancer Res Ther · 2025 Dec · PMID 41474245 · Publisher ↗
AIM: This systematic review and meta-analysis compared fibroblast activation protein inhibitor (FAPI) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) regarding diagnos...
AIM: This systematic review and meta-analysis compared fibroblast activation protein inhibitor (FAPI) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) regarding diagnostic efficacy in primary liver cancers, focusing on sensitivity, specificity, and clinical applicability. MATERIALS AND METHODS: PubMed was searched (up to July 31, 2024) for studies evaluating FAPI and FDG PET/CT for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. A total of 9 studies involving 214 patients and 416 lesions were analyzed. Study quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Diagnostic parameters were synthesized using R Studio's "Mada" package with a random-effects model. Heterogeneity was assessed via I² statistics. RESULTS: FAPI PET/CT exhibited superior pooled sensitivity (0.918, 95% CI: 0.862-0.953) to FDG PET/CT (0.472, 95% confidence interval [CI]: 0.309-0.642). FAPI demonstrated lower specificity than FDG (0.464, 95% CI: 0.281-0.647, vs. 0.678, 95% CI: 0.505-0.851). Furthermore, it obtained a higher area under the curve (0.846 vs. 0.627), indicating high overall diagnostic accuracy. Moreover, FAPI demonstrated superior performance in detecting small lesions (≤1 cm) and FDG-negative tumors, particularly in cirrhotic livers. Contrarily, FDG showed better specificity for benign lesions. Across studies, heterogeneity was mainly attributed to lesion size, cirrhosis prevalence, and tracer subtypes. CONCLUSION: FAPI PET/CT achieved higher sensitivity and diagnostic accuracy than FDG in primary liver cancers, particularly in early-stage and metabolically heterogeneous tumors. FAPI offers transformative potential for clinical use despite its lower specificity in patients with cirrhosis. To optimize integration into diagnostic pathways, standardized protocols and large-scale validation are needed.
Transarterial infusion chemotherapy combined with iodinated oil chemoembolization for the treatment of primary colorectal cancer.
Zhang J, Li X, Yin M … +4 more , Zhou G, Ma Y, Bi Y, Wu G
J Cancer Res Ther · 2025 Dec · PMID 41474244 · Publisher ↗
BACKGROUND: No report is available on the treatment of primary colorectal cancer (CRC) by transarterial chemotherapy combined with lipiodol chemoembolization in tumor-feeding arteries. AIMS: To determine the safety and e...
BACKGROUND: No report is available on the treatment of primary colorectal cancer (CRC) by transarterial chemotherapy combined with lipiodol chemoembolization in tumor-feeding arteries. AIMS: To determine the safety and efficacy of transarterial infusion chemotherapy (TAI) and lipiodol chemoembolization for the treatment of primary CRC. METHODS: Thirty-seven patients with advanced CRC received TAI and lipiodol chemoembolization once a month, 1-3 times in all. Clinical efficacy, complications, and effectiveness were evaluated 1 month after each session. RESULTS: All 37 patients were successfully treated. The most common complications were abdominal discomfort, nausea, tenesmus, and myelosuppression. The overall disease control and objective response rates were 97.3% and 67.6%, respectively. Twenty-four patients survived and 13 died; the median survival duration was 21.1 months. Age was a significant influencing factor of overall survival. CONCLUSION: Transarterial chemotherapy combined with lipiodol chemoembolization appears to be safe and effective for treating advanced CRC.
Uterine sarcomas: Computed tomography and magnetic resonance imaging findings.
Qu Q, Ma Z, Liu G … +3 more , Zhang X, Xu C, Wu X
J Cancer Res Ther · 2025 Dec · PMID 41474243 · Publisher ↗
PURPOSE: To summarize and analyze the computed tomography (CT) and magnetic resonance imaging (MRI) features of uterine sarcoma. METHODS AND MATERIAL: This retrospective study reviewed the clinical data and CT/MRI findin...
PURPOSE: To summarize and analyze the computed tomography (CT) and magnetic resonance imaging (MRI) features of uterine sarcoma. METHODS AND MATERIAL: This retrospective study reviewed the clinical data and CT/MRI findings of 15 patients with uterine sarcomas confirmed by surgery and pathology, focusing on their characteristic imaging manifestations. RESULTS: Among the 15 patients, eight had uterine smooth muscle sarcoma (four with lesions confined to the uterine cavity and four presenting as large pelvic masses; all were cystic); one had undifferentiated uterine sarcoma [low signal on TI-weighted imaging (T1WI), high signal on T2-weighted imaging (T2WI) with the clear border, and marginal ring-shaped high signals on diffusion-weighted image (DWI)]; two had uterine adenosarcoma (mixed-density nodular and mass-like lesions with marked heterogeneous enhancement); three had low-grade endometrial stromal sarcoma (iso- or hypointense on T1WI, hyper- or slightly hyperintense on T2WI, and markedly hyperintense on DWI); and one had high-grade endometrial stromal sarcoma (a large cystic-solid pelvic mass). Pathology confirmed that this last lesion invaded the plasma membrane and involved local sub-plasma tissue of the intestinal wall. CONCLUSION: Uterine sarcoma commonly presents as the large cystic pelvic mass with indistinct margins, irregular shape, and possible invasion of adjacent structures. MRI typically shows iso- or slightly low T1WI signals, mixed high T2WI signals, high or slightly high DWI signals, and heterogeneous enhancement. These findings may aid in improving diagnostic accuracy and guiding clinical management of uterine sarcoma.
Prophylactic hyperthermic intraperitoneal chemotherapy in locally advanced colorectal cancer: A propensity score matched cohort study.
Yang J, Sun K, Deng H
J Cancer Res Ther · 2025 Dec · PMID 41474242 · Publisher ↗
BACKGROUND: Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) remains controversial in locally advanced colorectal cancer (CRC). This study aimed to evaluate its survival benefits and safety. METHODS: A retr...
BACKGROUND: Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) remains controversial in locally advanced colorectal cancer (CRC). This study aimed to evaluate its survival benefits and safety. METHODS: A retrospective cohort of 3008 CRC patients undergoing resection (2014-2019) was analyzed. Propensity score matching (PSM) generated 188 HIPEC and 188 control patients. Outcomes included operative metrics, complications (Clavien-Dindo ≥III), and 3-year overall survival (OS)/disease-free survival (DFS). Multivariable Cox regression identified prognostic factors. RESULTS: Post-PSM, HIPEC required longer operative time (215 vs 185 minutes) and hospital stay (9.2 vs 7.5 days), with comparable major complications (12.8% vs 10.6%, P > 0.05). HIPEC showed superior 3-year OS (87.2% vs 80.5%, HR = 0.54, P = 0.029) and DFS (81.7% vs 75.2%, HR = 0.59, P = 0.037). Multivariable analysis confirmed HIPEC (OS: HR = 0.54, 95% CI: 0.31-0.94; DFS: HR = 0.59, 95% CI: 0.37-0.93) and laparoscopic approach as independent survival predictors. CONCLUSION: Prophylactic HIPEC (43°C, 60-90 minutes) may improve survival in locally advanced CRC without increasing major complications, supporting its integration into surgical practice. Further validation through multicenter trials is warranted.
The role of personalized 3D printed side hernia fixation plate in the care of patients with permanent colostomy for colorectal cancer.
Sun Y, Chen X, Zhang Q
J Cancer Res Ther · 2025 Dec · PMID 41474241 · Publisher ↗
OBJECTIVE: The research aims to study the application effect of personalized 3D printed side hernia fixation plates in the care of patients with permanent colostomy for colorectal cancer. METHODS: A total of 110 patients...
OBJECTIVE: The research aims to study the application effect of personalized 3D printed side hernia fixation plates in the care of patients with permanent colostomy for colorectal cancer. METHODS: A total of 110 patients with permanent colostomy of colorectal cancer are selected from the Wound Ostomy Nursing Clinic of the First People's Hospital of Huai'an City from December 2018 to January 2023. They are randomly divided into the research group and the control group, with 55 cases in each group. The control group uses a stoma pocket and wears an abdominal band to fix the tissue around the stoma, while the research group uses a 3D printed side hernia fixator to fix the tissue around the stoma with the abdominal band. At 1, 3, and 6 months after surgery, the inflammatory factors C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1β (IL-1β), and skin condition around the stoma scores are observed in both groups of patients. The incidence of stoma complications, pocket replacement frequency, abdominal belt wearing frequency, and abdominal belt displacement within 6 months are also analyzed. RESULT: The time effect and grouping exchange effect of changes in CRP, IL-6, IL-1β in both groups of patients were statistically significant (P < 0.05). At 1 month after surgery, there was no statistically significant difference in the expression levels of CRP, IL-6, and IL-1β between the two groups of patients (P > 0.05). At 3 and 6 months after surgery, the expression levels of CRP, IL-6, and IL-1β in the research group were significantly lower than those in the control group (P < 0.05). CONCLUSION: Patients with permanent colostomy for colorectal cancer can effectively reduce inflammatory reactions by wearing an abdominal strap on the basis of personalized 3D printed side hernia fixators.
A comparison of single session and multiple session microwave ablation for multiple lung malignancies.
Song B, Bai J, Lei H … +9 more , Zhou J, Yang Y, Wu Q, Huang M, Fan H, Zhao X, Deng C, Zhang J, Ding R
J Cancer Res Ther · 2025 Dec · PMID 41474240 · Publisher ↗
OBJECTIVES: The purpose of this study is to retrospectively compare the therapeutic efficacy and safety of single session microwave ablation (MWA) and multiple session MWA for multiple malignant lung tumors. METHODS: Ret...
OBJECTIVES: The purpose of this study is to retrospectively compare the therapeutic efficacy and safety of single session microwave ablation (MWA) and multiple session MWA for multiple malignant lung tumors. METHODS: Retrospective analysis was conducted on clinical and pathological data of 103 patients with such malignancies treated from January 2020 to December 2022. Patients were categorized based on the number of MWA sessions required. Patients who had received only one MWA treatment were included in the single session MWA group, and patients, who had received two or more MWA treatments were included in the multiple session MWA group. Chest-enhanced CT scans were performed at 1, 3, 6, and 12 months post-MWA to assess ablation outcomes. The primary focus was the median overall survival (mOS), while secondary endpoints encompassed median local progression-free survival (PFS), technical success rates, safety, and complication rate. Analysis was performed by log-rank test and Cox proportional hazard regression model, using the Common Terminology Standard for Adverse Events (version 5.0) to assess safety within 28 days after MWA. RESULTS: Of 103 patients with multiple malignant lung tumors, each undergoing at least two tumor treatments during 168 MWA sessions. The median OS for the entire cohort stood at 27 months, with a corresponding median local PFS of 26 months. Patients in the single session MWA group had a median OS of 33 months compared with 13.1 months for those in the multiple session group (P = 0.001). Notably, adverse factors affecting survival after adjusting for confounding variables included T stage (P = 0.002), comorbidity (P = 0.018), solid tumor interior environment (P = 0.043), and multiple session MWA sessions (P = 0.035). No produce-related deaths or grade 3 or 4 adverse events occurred, with pneumothorax being the most common complication (13.1%). There is no significant difference in the occurrence of complications between the two groups (P > 0.05). Additionally, single session MWA exhibited superior OS and local PFS compared to multiple session MWA sessions, with statistically significant differences. CONCLUSION: For multiple session lung malignant tumors, the single session MWA group is superior to MWA in terms of survival and local tumor control, with no statistically significant difference in the incidence of complications between the two groups. The findings suggest that single session MWA procedures might be advantageous over multiple session MWAs.
A multimodal intelligent model for the noninvasive prediction of vascular endothelial growth factor expression and prognostic stratification in breast cancer: A multicenter retrospective study.
Zhou Y, Liu Y, Chen P … +2 more , Ma Y, Wang T
J Cancer Res Ther · 2025 Dec · PMID 41474239 · Publisher ↗
BACKGROUND: Vascular endothelial growth factor (VEGF) overexpression is linked to aggressive metastasis and poor prognosis in patients with breast cancer. This study aimed to develop a noninvasive model integrating ultra...
BACKGROUND: Vascular endothelial growth factor (VEGF) overexpression is linked to aggressive metastasis and poor prognosis in patients with breast cancer. This study aimed to develop a noninvasive model integrating ultrasound and clinical information for VEGF prediction and to evaluate its clinical utility in risk stratification for lymph metastasis and prognosis. METHODS: Breast cancer ultrasound findings, clinical data, immunohistochemical results, and prognostic information were collected from three centers to develop the intelligent model. ResNet-50 was used to extract ultrasound features, which were then combined with clinical information using logistic regression. Class activation mapping and an alignment nomogram were used to visualize and explain the model's prediction process. Model performance was assessed using the area under the curve (AUC), confusion matrix, calibration curves, and decision curve analysis. Prognostic relevance was evaluated by examining the lymph node metastasis and recurrence-free survival (RFS) rates. RESULTS: Data from 609 patients were divided into four sets: training, validation, internal test, and external test. The combined model demonstrated satisfactory performance in the internal (AUC, 0.852; 95% confidence interval [CI], 0.756-0.928) and external (AUC, 0.837; 95% CI, 0.778-0.892) test sets. In the external test set, high-risk VEGF patients predicted by the combined model exhibited higher lymph node metastasis rates (67.8% vs. 12.1%; P < 0.001) and poorer RFS (log-rank P = 0.022). The prognostic accuracy for recurrence peaked at six months (AUC, 0.806). CONCLUSION: This noninvasive intelligent model could precisely predict VEGF expression, indicate the risk of lymph node metastasis, and provide prognostic insights.
Cryoablation combined with chemotherapy for the treatment of liver metastases.
Wang Y, Zhang WH, Guo YF … +3 more , Tian ZG, Yang M, Si TG
J Cancer Res Ther · 2025 Dec · PMID 41474238 · Publisher ↗
OBJECTIVE: This study aimed to investigate the clinical outcomes of cryoablation-chemotherapy combination for the treatment of liver metastases (LMs). MATERIALS AND METHODS: This study included 199 patients who received...
OBJECTIVE: This study aimed to investigate the clinical outcomes of cryoablation-chemotherapy combination for the treatment of liver metastases (LMs). MATERIALS AND METHODS: This study included 199 patients who received cryoablation-chemotherapy combination for LM treatment at our hospital from October 2009 to November 2017. The patients' clinical characteristics and their overall survival (OS), complication, local tumor control, and recurrence rates were assessed. RESULTS: Of the patients, 66 (33.2%) and 133 (66.8%) developed colorectal liver metastases (CLMs) and noncolorectal LMs (NCLMs), respectively. Their follow-up duration ranged from 7 to 74 months (median: 37 months), with 1-, 3-, and 5-year OS rates of 71.2%, 40.9%, and 19%, respectively. The OS rates in the CLM group were 81.7%, 57.2%, and 31.9%, compared with 68.3%, 34.4%, and 12% in the NCLM group, respectively. As regards the initial local treatment efficacy, the CLM group exhibited an objective response rate (ORR) of 74.2% and a disease control rate (DCR) of 95.5%, compared with 60.2% and 85.7%, respectively, in the NCLM group, with significant differences observed between the groups (ORR, P = 0.050; DCR, P = 0.039). Serious postoperative complications rarely occurred in both groups. CONCLUSION: Cryoablation-chemotherapy combination treatment is safe, feasible, and effective for LMs. Its efficacy is mainly dependent on the primary tumor site, making it a potential alternative for clinical treatments. CLMs had better prognosis than NCLMs. A maximum tumor diameter ≥3 cm, time to LMs ≤12 months, and absence of neoadjuvant TACE were identified as statistically significant predictors of poor prognosis in patients with LM.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe