Deng R, Lv J, Mu L
… +3 more, Xu G, Zhang W, Zhang C
J Cancer Res Ther
· 2025 Dec · PMID 41474237
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BACKGROUND: The prognosis for patients with small cell lung cancer (SCLC), who develop liver metastases (LM) is extremely poor, and treatment options are limited. This study aimed to evaluate the efficacy and safety of h...BACKGROUND: The prognosis for patients with small cell lung cancer (SCLC), who develop liver metastases (LM) is extremely poor, and treatment options are limited. This study aimed to evaluate the efficacy and safety of hepatic arterial infusion (HAI) chemotherapy combined with systemic chemotherapy for patients diagnosed with LM-SCLC. SUBJECT AND METHODS: From January 2019 to December 2023, HAI catheter systems were implanted in 15 patients with LM-SCLC, guided by digital subtraction angiography. All patients received systemic chemotherapy in combination with HAI using gemcitabine and floxuridine (FUDR). RESULTS: The overall response rate for intrahepatic lesions was 66.7%, including one patient (6.7%) with a complete response and nine (60.0%) with a partial response. Additionally, the median overall survival (mOS) was 13 months (95% confidence interval, 11.4-14.6 months). Notably, none of the patients experienced grade 4 adverse effects. However, the grade 3 adverse effects included leukopenia and neutropenia, which were well tolerated by all the patients. CONCLUSIONS: HAI of gemcitabine and FUDR, alongside systemic chemotherapy, may serve as an effective treatment strategy for achieving a high local response and prolonging mOS in patients with LM-SCLC, while also being associated with a relatively low incidence of adverse effects.
J Cancer Res Ther
· 2025 Dec · PMID 41474236
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PURPOSE: This retrospective study evaluated the safety and efficacy of co-ablation (Co-A) for subpleural malignant pulmonary nodules (SMPNs). MATERIALS AND METHODS: A total of 88 consecutive malignant lung tumor patients...PURPOSE: This retrospective study evaluated the safety and efficacy of co-ablation (Co-A) for subpleural malignant pulmonary nodules (SMPNs). MATERIALS AND METHODS: A total of 88 consecutive malignant lung tumor patients treated for Co-A were retrospectively reviewed. Subpleural lesions were assessed using computed tomography (CT). In the lung window, a distance of 1 cm between the nodule and the pleura was defined as subpleural. Overall, 68 patients comprising 41 men and 27 women (mean age, 63.54 ± 13.82 years; age range, 15-87 years) were enrolled, dividing into the SMPN group (n = 53) and the nonsubpleural malignant pulmonary nodules group (NSMPN, n = 15). The mean tumor size was 22.78 ± 6.30 mm (range, 10-30 mm). Follow-up was conducted using CT at 1, 3, and 6 months after Co-A, and the complications and safety profiles were recorded. RESULTS: The technical success rate was 100%. No significant difference in overall complication rate was observed between the SMPN (40.7%, 24/59) and NSMPN (50.6%, 10/19) groups (χ2 = 0.835, P = 0.361). The median follow-up duration in all patients was 5.38 ± 3.14 months (range, 3-14 months). The 3- and 6-month local recurrence-free survival (LRFS) rates in the SMPN and NSMPN groups were 97.7% and 100%, respectively, and 90.9% and 100%, respectively (P > 0.05). CONCLUSION: These findings indicate that Co-A may be a safe and effective treatment strategy for SMPNs.
Liu Z, Guo Y, Wang P
… +4 more, Lu S, Li MM, Li Z, Xue T
J Cancer Res Ther
· 2025 Dec · PMID 41474235
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OBJECTIVE: This study aimed to explore the efficacy and prognostic value of alpha-fetoprotein (AFP) and des-gamma-carboxyprothrombin (DCP) in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoemb...OBJECTIVE: This study aimed to explore the efficacy and prognostic value of alpha-fetoprotein (AFP) and des-gamma-carboxyprothrombin (DCP) in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) treatment. SUBJECTS AND METHODS: Relationships between the baseline levels of AFP and DCP and the clinical characteristics of 314 patients with HCC who underwent TACE were retrospectively analyzed. Kaplan-Meier curves and Cox regression models were used to analyze the survival data. RESULTS: Before TACE, the patient distribution was as follows: 180 were positive for both AFP and DCP, 37 were negative for both, 24 were positive for AFP only, and 73 were positive for DCP only. Of the 131 patients included in the follow-up study after TACE treatment, 47 (35.88%) belonged to the AFP and DCP double-response group, 38 (29.01%) to the single-response group, and 46 (35.11%) to the no-response group. The overall objective response rate was significantly higher in the double- and single-response groups than in the no-response group (P < 0.001). The overall survival (OS) and progression-free survival (PFS) rates in the double-response group were significantly longer than those in the other two groups (P < 0.001). The response types of AFP and DCP were independent risk factors for PFS (P = 0.003) and OS (P = 0.007). CONCLUSION: The combination of AFP and DCP provides a valuable serum biomarker for assessing the efficacy of TACE in patients with HCC. The goal for TACE treatment in dual-positive patients is to achieve a dual response for AFP and DCP.
Gao L, Xi X, Jiang Y
… +7 more, Gao Q, Tang J, Yang X, Zhu S, Zhao R, Lai X, Zhang B
J Cancer Res Ther
· 2025 Dec · PMID 41474234
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CONTEXT: Thyroid nodules with intermediate- and low-suspicion patterns are difficult to diagnose, based on the 2015 American Thyroid Association (ATA) stratification. AIMS: We evaluated the performance of shear wave elas...CONTEXT: Thyroid nodules with intermediate- and low-suspicion patterns are difficult to diagnose, based on the 2015 American Thyroid Association (ATA) stratification. AIMS: We evaluated the performance of shear wave elastography (SWE) as an adjunctive tool to ultrasound (US) in predicting the malignancy of these thyroid nodules. SETTINGS AND DESIGN: Thyroid nodules (n = 270) collected from January to April 2018 with low or intermediate suspicion for malignancy were evaluated. METHODS, MATERIALS, AND STATISTICAL ANALYSES: The maximum SWE elasticity values (Emax) for the nodules were examined and subsequently confirmed by pathology. SWE and ATA guidelines, as well as a combination of the two, were applied. RESULTS: Combined with SWE, the diagnostic accuracy of the ATA categories was superior to the ATA categories alone (area under the curve, AUC 0.81 vs. 0.72, P < 0.05). Based on the ATA categories, the percentages of malignancy in the nodules with low and intermediate suspicion for malignancy were 21.1% (12/57) and 54.2% (13/24), respectively. After adjustments for the use of SWE, the nodules were restratified as very low, low, intermediate, and high suspicion of malignancy. The percentages of malignancy for the very low, low, intermediate, and high suspicion nodules were 0 (0/26), 27.3% (3/11), 37.8% (12/31), and 76.9% (10/13), respectively. CONCLUSION: SWE may be used to differentiate malignant and benign nodules in addition to the ATA pattern. Combined with the ATA pattern, SWE supplemented US for predicting nodules with low and intermediate suspicion of malignancy.
J Cancer Res Ther
· 2025 Dec · PMID 41474233
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BACKGROUND: Invasive breast carcinoma of no special type with medullary pattern (BCNST-MP) is a rare subtype of breast cancer. Previous studies have reported the high prevalence of the triple-negative phenotype in BCNST-...BACKGROUND: Invasive breast carcinoma of no special type with medullary pattern (BCNST-MP) is a rare subtype of breast cancer. Previous studies have reported the high prevalence of the triple-negative phenotype in BCNST-MP. This study aimed to investigate the prevalence of human epidermal growth factor receptor 2 (HER2)-low and androgen receptor (AR) expression in this distinct breast cancer subtype. METHODS: We conducted a retrospective analysis of breast cancer patients diagnosed at our center between 2019 and 2024. Medical records and pathology reports were reviewed to assess the clinicopathological characteristics of BCNST-MP. RESULTS: A total of 45 patients with BCNST-MP met the inclusion criteria. The median age at diagnosis was 51 years. Most tumors (93.3%) measured ≤5 cm, and axillary lymph node metastasis was observed in 26.7% of cases. Eighty percent of the patients were estrogen receptor (ER)-negative, 84% were progesterone receptor (PR)-negative, and 75.6% were AR-negative. Regarding the HER2 status, 15.6% were HER2-positive, 33.3% exhibited HER2-low expression, and 51.1% had HER2-zero expression. With a median follow-up duration of 26 months, only one patient-a 30-year-old with triple-negative breast cancer-developed distant metastasis. An 82-year-old died of a cerebrovascular accident. CONCLUSIONS: Our findings suggest that BCNST-MP tumors are rarely larger than 5 cm and are frequently lymph node-negative. Most patients were negative for ER, PR, AR, and HER2. Notably, HER2-low expression was observed in approximately 30% of cases, suggesting therapeutic implications.
Zhang T, An C, Li W
… +25 more, Li X, Li S, Deng H, Xiao Y, Huang X, Li J, Hasegawa T, Takaki H, Matsui Y, Chi JC, Li C, Fan W, Huang J, Lei G, Zuo M, Chen Q, Shen L, Han J, Pua U, Li X, Huang K, Hong H, Ye X, Wu P, Guideline Committee for Asian Conference on Tumor Ablation (ACTA)
J Cancer Res Ther
· 2025 Dec · PMID 41474232
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Percutaneous image-guided thermal ablation (IGTA) is increasingly utilized for the management of primary and metastatic lung tumors. Several academic societies across various countries have issued clinical practice guide...Percutaneous image-guided thermal ablation (IGTA) is increasingly utilized for the management of primary and metastatic lung tumors. Several academic societies across various countries have issued clinical practice guidelines, opinion statements, and recommendations for IGTA in the treatment of lung tumors. However, unresolved conceptual and practical challenges persist, underscoring the need for a more comprehensive consensus on the safe and effective application of IGTA, particularly in Asian countries. Consequently, the guideline committee of the Asian Conference on Tumor Ablation (ACTA) established a dedicated working group to develop recommendations for the clinical use of IGTA in lung tumors. Through a thorough analysis of current literature and key clinical questions, the ACTA working group identified 10 critical issues, including indications, modality selection, technical considerations, and management of complications. Following extensive discussions and iterative revisions, experts from Asia-Pacific countries have formulated a consensus to guide clinical practice.
J Cancer Res Ther
· 2025 Dec · PMID 41452010
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OBJECTIVES: MDM2 inhibition restores p53 function, and even mutant p53 can induce cancer cell apoptosis. Notably, apoptosis and pyroptosis may interconvert during chemotherapy. This study aimed to explore the role of the...OBJECTIVES: MDM2 inhibition restores p53 function, and even mutant p53 can induce cancer cell apoptosis. Notably, apoptosis and pyroptosis may interconvert during chemotherapy. This study aimed to explore the role of the MDM2-p53 pathway in the regulation of GSDME-mediated pyroptosis in lung adenocarcinoma. METHODS: Immunohistochemistry and Western blotting were employed to measure the expression levels of GSDMD, GSDME, cleaved PARP, and MDM2. Nutlin-3, an MDM2 inhibitor, was administered to 5-FU-treated wild-type A549 cells, wild-type HBE cells, GSDME-overexpressing HBE cells, and A549 cells overexpressing p53 codon 72 mutation. RESULTS: GSDMD and GSDME were expressed in lung adenocarcinoma tissues, adjacent nontumor tissues, and noncancerous lung tissues, whereas only GSDME was expressed in A549 and HBE cells. After chemotherapy, the N-terminal fragment of GSDME was expressed in HBE and A549 cells. GSDME had a significantly lower protein level in HBE cells than in A549 cells ( P = 0.0092). GSDME overexpression markedly increased pyroptosis in A549 ( P = 0.01) and HBE cells ( P = 1.72 × 10 -6 ). Nutlin-3 significantly reduced cell viability and pyroptosis while increasing apoptosis in 5-FU-treated wild-type A549 cells, A549 cells with the p53 codon 72 mutation, and GSDME-overexpressing HBE cells. However, it exerted no significant effects on wild-type HBE cells. CONCLUSIONS: GSDME-mediated pyroptosis plays a pivotal role in chemotherapy-induced cell death in lung adenocarcinoma. MDM2 inhibition, which switches pyroptosis to apoptosis, can be employed to regulate chemotherapy-induced pyroptosis in lung cancer cells and normal tissue cells.
Wei X, Yang L, Gong T
… +5 more, Chen X, Teng J, Dou W, Fu L, Wang G
J Cancer Res Ther
· 2025 Dec · PMID 41272816
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OBJECTIVE: To evaluate diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for the prenatal differentiation of fetal adrenal neuroblastoma (NB) from benign masses. METHODS: This retrospective st...OBJECTIVE: To evaluate diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for the prenatal differentiation of fetal adrenal neuroblastoma (NB) from benign masses. METHODS: This retrospective study analyzed prenatal magnetic resonance imaging/DWI data from 54 pregnant women (59 adrenal masses) with a suspected solid adrenal mass on ultrasound. Cases with severe malformations or poor image quality were excluded. The minimum ADC (ADC min ), mean ADC (ADC mean ), and relative ADC (rADC) values within the tumor solid components were measured. Group comparisons and receiver operating characteristic (ROC) curve analysis were performed to assess the diagnostic performance. RESULTS: Eighteen masses (30.5%) were classified as NB, while the remaining 41 (69.5%) were benign, including sequestration, hematoma, and teratoma. The NB group showed significantly greater gestational age at detection (mean age, 35 weeks), higher right adrenal prevalence (66.7%), and larger maximum diameters (3.6 cm vs. 2.4 cm; P < 0.01) compared to the non-NB group. The ADC min , ADC mean , and rADC were significantly lower in the NB group ( P < 0.001). ROC analysis identified ADC min as the optimal diagnostic parameter (area under the curve = 0.981). An ADC min threshold of 1382 μm²/s yielded 97.56% sensitivity and 100% specificity. CONCLUSION: These findings indicate that the quantitative DWI parameter ADC min can reliably differentiate fetal adrenal NB from benign lesions prenatally. Its high sensitivity and specificity may provide an objective basis for clinical decisions and optimized perinatal management.
Li Z, Li M, Yang Y
… +4 more, Sun Z, Chang Z, Chen Y, Zhao L
J Cancer Res Ther
· 2025 Dec · PMID 41134601
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BACKGROUND: Gut microorganisms are involved in the occurrence and progression of various types of cancer, including colorectal cancer. Previous studies have shown that the disruption of commensal homeostasis can promote...BACKGROUND: Gut microorganisms are involved in the occurrence and progression of various types of cancer, including colorectal cancer. Previous studies have shown that the disruption of commensal homeostasis can promote tumor metastasis. The present study aimed to investigate the effects of gut commensal dysbiosis on the risk of colorectal cancer liver metastasis (CRLM) and its mechanisms. MATERIALS AND METHODS: A mouse model of CRLM with the commensal dysbiosis background was established. This model was used to investigate the impact of commensal dysbiosis on CRLM. RESULTS: Commensal dysbiosis promoted CRLM development via the C-C chemokine ligand 6 ( CCL6 ) and C-C chemokine receptor 1 ( CCR1 ) axis. Moreover, it altered the liver tumor microenvironment (TME) by recruiting tumor-associated macrophages (TAMs), notably M2-like TAMs, and promoted liver metastasis growth. Liver metastasis was promoted via the upregulation of CCL6 expression levels, which resulted in CCR1 +TAM infiltration into the TME. Notably, inhibiting CCR1 expression could reduce CRLM. CONCLUSION: Commensal dysbiosis could promote CRLM development via CCL6/CCR1 signaling. Targeting this signaling axis could be an effective method to inhibit CRLM by regulating the TME.
Gejji MB, Hulikal N, Singaram NK
… +1 more, Alekhya M
J Cancer Res Ther
· 2025 Jul · PMID 41004303
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Primary retroperitoneal transitional cell carcinomas (TCCs) are very rare tumors arising from the urogenital ridge remnants. Till date only eight cases have been reported. Recently, we treated a patient who presented wit...Primary retroperitoneal transitional cell carcinomas (TCCs) are very rare tumors arising from the urogenital ridge remnants. Till date only eight cases have been reported. Recently, we treated a patient who presented with an advanced, large tumor with major vascular infiltration with chemotherapy and radiotherapy before surgery. Though preoperative imaging did not show much response, the tumor could be resected completely along with the left kidney and part of the abdominal wall. Final histopathological examination revealed no viable tumor in the entire specimen. This case report details the clinical and management aspects of such a rare tumor with a review of the previously reported cases.
J Cancer Res Ther
· 2025 Jul · PMID 41004302
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Schwannomas are solid, well-encapsulated masses that develop eccentrically toward the nerve from that they originate. They typically affect the head and neck and involve Schwann cells surrounding autonomic, peripheral, a...Schwannomas are solid, well-encapsulated masses that develop eccentrically toward the nerve from that they originate. They typically affect the head and neck and involve Schwann cells surrounding autonomic, peripheral, and cranial nerves. Intraoral schwannoma is most affected by the tongue, with 54% male preponderance. The most common neural tumors in the oral cavity include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor (MPNST). CD56 is more specific in schwannomas than neurofibromas, with CD56 expressed strongly in 90% of schwannomas and negative in 86% of neurofibromas. Schwannoma has various histological variants, including ancient schwannoma, Cellular schwannoma, epithelioid schwannoma, Microcystic/reticular variant, Neuroblastoma-like variant, and plexiform schwannoma. CD56, when combined with S-100 and calretinin, can help diagnose peripheral nerve sheath tumors like schwannomas and neurofibromas. Surgical excision with nerve preservation is typically curative, but size and location may affect the surgical strategy. Schwannoma management aims to remove the capsule, minimize malignant emergence, and make the prognosis favorable.
Sawaimul KD, Gore C, Dabaria SM
… +1 more, Saikia S
J Cancer Res Ther
· 2025 Jul · PMID 41004301
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Schwannomas are benign, slow-growing tumors of neural origin arising from the Schwann cells. They usually arise along the course of the nerves in the body. Lung is one of the rarest site for schwannoma, hence making its...Schwannomas are benign, slow-growing tumors of neural origin arising from the Schwann cells. They usually arise along the course of the nerves in the body. Lung is one of the rarest site for schwannoma, hence making its diagnosis more difficult. Biopsy and IHC play the pivotal role in reaching the final diagnosis. Thereby highlighting the significance of making a conclusive diagnosis of benign nerve tumors in these relatively rare places. We are presenting a 66-year-old male diagnosed as intrapulmonary schwannoma on histopathology and immunohistochemistry.
J Cancer Res Ther
· 2025 Jul · PMID 41004300
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Apart from usual occurrence of abscess or appendicitis, carcinoma of appendix is quite rare to occur. Yet, here, we describe a reported case of appendiceal adenocarcinoma that clinically presented as appendicitis in a 60...Apart from usual occurrence of abscess or appendicitis, carcinoma of appendix is quite rare to occur. Yet, here, we describe a reported case of appendiceal adenocarcinoma that clinically presented as appendicitis in a 60-year-old man. The patient presented with pain in right iliac fossa, which was sudden in onset, nonradiating, and progressively increased in severity with complaints of nausea. He had no history of fever, vomiting, cough, or constipation. Computed tomography revealed a well-defined collection with surrounding fat stranding and peritoneal thickening in right iliac fossa measuring 2.6 * 4.2 * 3.5 cm, volume 20 cc. Appendix was retrocecal and thickened with tip leading to the collection. A few prominent mesenteric lymph nodes were seen in right iliac fossa. These features suggested perforated appendix with abscess formation. An open appendicectomy was done under general anesthesia, and the specimen was sent for histopathological analysis. On a surprise note, the microscopic section of the specimen revealed tumor cells with a conventional glandular appearance favoring a diagnosis of moderately differentiated adenocarcinoma, following which an elective right hemicolectomy was advised. Nonspecific symptoms and difficulties in reaching a diagnosis preoperatively may contribute to underreporting of appendiceal carcinomas. Complete surgical excision and/or chemotherapy may be necessary and help in the better prognosis of the patient.
Dubey A, Voni SK, Pradhan S
… +2 more, Dash SS, Panda SS
J Cancer Res Ther
· 2025 Jul · PMID 41004299
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Hepatoid carcinomas are a set of extrahepatic neoplasms representing focal hepatocellular carcinoma on morphology and immunohistochemistry. Hepatoid carcinoma is reported primarily in the ovary and stomach, but its prese...Hepatoid carcinomas are a set of extrahepatic neoplasms representing focal hepatocellular carcinoma on morphology and immunohistochemistry. Hepatoid carcinoma is reported primarily in the ovary and stomach, but its presence in the urinary tract, lung, and biliary tract has also been reported. Clinical presentation, diagnosis, treatment, and prognosis of pancreatic hepatoid carcinomas are not well understood due to the rarity of available literature. Our case was a female of 33 years of age who had pain in her abdomen for three months. Serum carcinoembryonic antigen was raised, and alpha-fetoprotein was normal at baseline. A contrast-enhanced computed tomography scan of the abdomen, pelvis, and thorax revealed a pancreatic body mass with regional nodal metastases. Whole-body positron emission tomography/computed tomography scan showed the mass in the body of the pancreas encasing the splenic vein and splenic-portal confluence with regional nodal involvement. Biopsy and immunohistochemistry of the pancreatic mass revealed pancreatic hepatoid carcinoma. Post-discussion in multidisciplinary tumor board, it was found to be unresectable and hence started on modified FOLFIRINOX for four cycles, following which the patient developed multiple liver lesions, eastern cooperative oncology group performance status deteriorated to IV, following which the patient kept on best supportive care and died after four months. Due to the rarity of this tumor and as per the limited literature available, the mainstay treatment for pancreatic hepatoid carcinoma remains complete surgical resection with significantly improved survival. The prognosis cannot be predicted precisely due to a lack of evidence-based data.
J Cancer Res Ther
· 2025 Jul · PMID 41004298
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Cancer has been acknowledged as a global public health concern owing to its universal presence, involvement of different organs, resulting sufferings, impairment in the quality of life, and associated complications, incl...Cancer has been acknowledged as a global public health concern owing to its universal presence, involvement of different organs, resulting sufferings, impairment in the quality of life, and associated complications, including a fatal outcome. With the rising popularity of social media platforms, there are definite chances that these online forums are the potential drivers and media for spreading stigma. Digital platforms provide a platform for cancer survivors to share their journey and experiences, which contrasts with the traditional stigma resulting from secrecy and isolation in the earlier times. The combination of these merits justifies the need to integrate social media as a part of the comprehensive stigma-reduction initiatives, as they are scalable and cost-effective as well. In conclusion, social media can have both positive and negative consequences on cancer stigma in the community, and remarkably can influence public attitudes and access to cancer care. The need of the hour is to integrate these digital strategies with the traditional approach to create a more knowledgeable and stigma-free environment for people diagnosed with cancer.
Aashita, Dagar A, Ghosh A
… +9 more, Vij S, Meena JK, Bhopale S, Kamboj K, Chaudhari PB, Sharma A, Kumar A, Sharma D, Mallick S
J Cancer Res Ther
· 2025 Jul · PMID 41004297
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INTRODUCTION: Radiation therapy plays a crucial role in the management of pediatric cancer. With recent advancements in treatment techniques and radiation delivery, stricter immobilization is required. However, achieving...INTRODUCTION: Radiation therapy plays a crucial role in the management of pediatric cancer. With recent advancements in treatment techniques and radiation delivery, stricter immobilization is required. However, achieving this in pediatric patients is challenging and often necessitates daily anesthesia. In this study, we present an audit of pediatric patients who underwent radiation therapy under anesthesia, highlighting associated complications and providing a roadmap for resource allocation. MATERIALS AND METHODS: We collected data on pediatric patients who required radiotherapy under anesthesia, including demographic details, tumor characteristics, anesthesia specifics, observed complications, and any treatment gaps. Descriptive statistics were used to analyze demographic, tumor, and treatment characteristics. Univariate and multivariate analyses were performed to identify correlations with various variables. RESULTS: From January 2021 to December 2023, 67 patients were scheduled for radiotherapy with daily anesthesia. The median age of the patients was 4 years (interquartile range: 2-5 years). Of these, 34 patients required anesthesia for the entire course of treatment, 22 patients needed anesthesia for part of the treatment, and seven patients did not require anesthesia after the simulation. Overall, anesthesia was needed for 59.12% of sessions. Complications occurred in 66 sessions (8.2%) involving 26 patients. Treatment had to be paused in eight cases, with a median delay of 8 days. The treatment compliance rate was 96.9%. An age of <3 years was significantly associated with the need for anesthesia during radiation. The complication rate was notably higher in patients who required anesthesia for the entire course of radiotherapy. CONCLUSION: While the use of anesthesia ensures proper immobilization during radiation treatment for pediatric patients, it carries the risk of complications. Therefore, it is essential to continuously explore and support efforts to allow patients to undergo radiation without the need for anesthesia.
Güngördük K, Demirkiran F, Khatib G
… +26 more, Öz M, Gülseren V, Minareci Y, Sanci M, Şahin H, Tosun Ö, Taskin S, Akman L, Özçelik B, Dogan S, Yalçin Y, Yalcın İ, Çebi S, Sözen H, Vatansever D, Dogan NU, Açikgöz AS, Özerkan K, Terek C, Aslan K, Öge T, Taskıran Ç, Ortaç F, Vardar MA, Ayhan A, Arvas M
J Cancer Res Ther
· 2025 Jul · PMID 41004296
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AIM: This study evaluated predictors and treatment of isolated vulvar recurrence (IVR) in patients with stage I-II tumors locally confined to the vulva. METHODS: We retrospectively collected data from patients with stage...AIM: This study evaluated predictors and treatment of isolated vulvar recurrence (IVR) in patients with stage I-II tumors locally confined to the vulva. METHODS: We retrospectively collected data from patients with stage I-II vulvar squamous cell carcinoma (VSCC) who underwent surgery for vulvar cancer between 2005 and 2021. The IVR group comprised patients with stage I-II tumors at the time of initial diagnosis who developed recurrence confined to the vulvar region after initial treatment. RESULTS: This study included 416 patients with early-stage (stage I-II) VSCC. IVR was developed in 67 (16.1%) patients; the remaining 349 patients were included in the control group. Independent predictors of IVR were depth of invasion, perineural invasion, and positive surgical margins. Among patients with tumors confined to the vulva at the time of initial diagnosis, the 5-year overall survival rates were 59.0% and 87.0% in the IVR and control groups, respectively (P < 0.001). In the IVR group, the cumulative rates of local relapse were 38.8% in the first year, 58.2% in the second year, and 74.6% in the third year. CONCLUSION: Independent predictors of IVR in early-stage VSCC were depth of invasion, perineural invasion, and positive surgical margins. Approximately two-thirds of local recurrences occurred in the first 3 years after treatment.
Pal PR, Paul P, Patne SCU
… +3 more, Chowdhury Z, Dhal I, Haiyat S
J Cancer Res Ther
· 2025 Jul · PMID 41004295
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BACKGROUND: Gall bladder (GB) is a rare site of neuroendocrine carcinoma (NEC). Gallbladder neuroendocrine carcinoma (GB-NEC) comprises only ~0.2% of all gastrointestinal NECs and 4% of all GB cancers. In the published l...BACKGROUND: Gall bladder (GB) is a rare site of neuroendocrine carcinoma (NEC). Gallbladder neuroendocrine carcinoma (GB-NEC) comprises only ~0.2% of all gastrointestinal NECs and 4% of all GB cancers. In the published literature, only a few isolated case reports and rare case series of GB-NEC are available. Worldwide, the largest series of GB-NEC reported is of 19 cases from India. In this study, we present clinicopathological features of 56 cases of GB-NEC diagnosed in a tertiary care cancer hospital of northern part of India. AIMS: To study the clinicopathological and immunohistochemical features of GB-NEC from the archives. METHODS: Retrospective data of GB-NEC, diagnosed over 53 months were collected from institutional electronic medical records. Hematoxylin and eosin (H and E) stained slides and corresponding immunohistochemistry slides were reviewed and included in the study. Data was compiled and basic statistical analysis was done. RESULTS: GB-NEC constituted 3.19% (n = 56/1752) of all GB carcinomas. Histological types of GB-NEC were: small cell NEC (96.4%, n = 54), large cell NEC (n = 1), and NEC with sarcomatous differentiation (n = 1). The diagnosis was ratified by use of combination of two neuroendocrine markers in varying combination comprising of Synaptophysin, chromogranin and INSMI1. Ki-67 index ranged from 50%-80% in 6 cases and more than 80% in 10 cases where count of mitotic figures was limited by extensive areas of necrosis. Follow-up of 6-8 months was available for 22 patients out of which 21 cases were living with disease. Twenty-two patients were treated with palliative chemotherapy. CONCLUSIONS: GB-NEC is a rare and aggressive malignancy with poor prognosis due to advanced clinical stage of presentation and limited availability of treatment options.
Khazir M, Akram M, Afrose R
… +2 more, Alam MS, Khan M
J Cancer Res Ther
· 2025 Jul · PMID 41004294
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INTRODUCTION: The distribution of cancer burden is unequal across the different age groups. The AYA age group have been defined by the National Cancer Institute as diagnoses occurring between the ages of 15 and 39. This...INTRODUCTION: The distribution of cancer burden is unequal across the different age groups. The AYA age group have been defined by the National Cancer Institute as diagnoses occurring between the ages of 15 and 39. This age group shows the different features in terms of cancer biology, risk factors, prognosis etc., as compare to the other age groups. MATERIAL AND METHODS: This was a retrospective observational study. Data collection was done from 2017 to 2021. Data was collected from Hospital Based Cancer Registry (HBCR) that registers all new histopathologically proven cancers reporting to its various clinical departments. Data regarding age, gender and site were collected. A standardized hospital-based cancer registries core form was used for the collection of the data. RESULT: From the year 2017-2021 a total of 12,827 cancer patients were registered in our HBCR. From the total number 7,583 (59.12%) were males and 5,244 (40.88%) were females. In these 5 years 2,874 (22.4%) were registered in our hospital in the age group of 15-39 years (AYA) and 9953 (77.59%) were 40 and above the 40 years of age. In case of females breast cancer in adolescents (15-29) accounts about 6.77% next to breast cancer ovarian cancer accounts about 3.38%, while as in case of adults (29-39) the breast cancer remains at the highest percentage of 12.12% but uterine cancer comes at the second number with 6.63% this picture continues in the older adults with breast cancer (9.7%) at the highest percentage and next to breast cancer uterine cancer remains at the second number. Head and neck cancer cases were highest in males in both the age groups of AYA population that is adolescents (15-29) and in adults (29-39) with 17.41% and 35.7% respectively. The time trends of AYA cancers and old age cancers from 2017 to 2021 in males was showing an increasing trend with 18.45% to 21.53% except for the year 2019 when the drop was found and it might be because of the Covid-19 pandemic in India. The time trend of AYA cancers and old age cancers from 2017 to 2021 in female patients was showing an increasing trend from 19.34% to 27.05%. CONCLUSION: This study was done to find out the cancer burden of AYAs. The purpose of this study was to find out the specific AYA cancer profile and highlight the need of targeted cancer control measures to reduce the cancer burden in this age group.