Med Sci Monit Basic Res [JOURNAL]
Sun
200 papers
Retracted: Modeled Behavioral Evaluation of the Neuropathic Pain With Social Defect in Rats: A Preliminary Methodology Evaluation.
Wang X, Feng SW, Wang F … +1 more , Xu S
Med Sci Monit Basic Res · 2026 May · PMID 42226626 · Full text
Retraction Notice:The authors have requested retraction following the identification of errors in the data.Reference:Xian Wang, Shan Wu Feng, Fuzhou Wang, Shiqin Xu, Modeled Behavioral Evaluation of the Neuropathic Pain...
Retraction Notice:The authors have requested retraction following the identification of errors in the data.Reference:Xian Wang, Shan Wu Feng, Fuzhou Wang, Shiqin Xu, Modeled Behavioral Evaluation of the Neuropathic Pain with Social Defect in Rats:A Preliminary Methodology Evaluation. Med Sci Monit Basic Res. 2014; 20: 164-169. DOI: 10.12659/MSMBR.892615.
Therapeutic Mechanisms of Jinshuiqing in IgA Nephropathy: A Transcriptomic Analysis.
Zha Z, Song W, Wang R … +3 more , Zhang X, Liu X, Wang L
Med Sci Monit Basic Res · 2025 Aug · PMID 40916551 · Full text
BACKGROUND This study aims to explore the therapeutic mechanisms of Jinshuiqing (JSQ) in IgA nephropathy (IgAN) using transcriptomic analysis and animal experimentation. MATERIAL AND METHODS Six-week-old male C57BL/6 mic...
BACKGROUND This study aims to explore the therapeutic mechanisms of Jinshuiqing (JSQ) in IgA nephropathy (IgAN) using transcriptomic analysis and animal experimentation. MATERIAL AND METHODS Six-week-old male C57BL/6 mice (20±2 g) were divided into 2 groups: IgAN model and JSQ-treated. The IgAN model was induced in SIRT3 knockout mice with acidified BSA, CCl4, castor oil, and LPS injections. The IgAN group received saline, while the JSQ group was treated with JSQ (4 g/kg/day) for 11 weeks. Following euthanasia, kidney tissues were collected for transcriptomic analysis. RNA extraction and sequencing were performed, followed by differential gene expression and pathway enrichment analysis to assess JSQ's effects. RESULTS PCA and correlation analysis showed distinct differences between the JSQ-treated and control groups. Differential gene expression identified 118 genes with significant changes, indicating that JSQ induces transcriptional alterations. Gene ontology (GO) and KEGG enrichment analyses revealed that JSQ affects pathways related to inflammation, oxidative stress, and metabolism, suggesting its potential to improve kidney function and regulate immune responses in IgAN. CONCLUSIONS JSQ treatment modulates gene expression in IgAN mice, influencing pathways linked to inflammation, gut microbiota, and kidney function. These findings provide insight into how JSQ alleviates inflammation and promotes renal health, offering genetic evidence for its therapeutic efficacy in IgAN.
Efficacy of Different Concentrations of Melatonin on Cultured Human Periodontal Ligament Stem Cells.
Alauti RY, Mukhtar AH, Alasqah M … +2 more , Alenazi MH, Gufran K
Med Sci Monit Basic Res · 2025 Jun · PMID 40457609 · Full text
BACKGROUND Due to their good differentiation abilities, human periodontal ligament stem cells (hPDLSCs) and tissue engineering treatment modalities are used to treat bone defects due to periodontitis. This in-vitro study...
BACKGROUND Due to their good differentiation abilities, human periodontal ligament stem cells (hPDLSCs) and tissue engineering treatment modalities are used to treat bone defects due to periodontitis. This in-vitro study aimed to determine the effects of different melatonin concentrations on the viability of cultured periodontal ligament stem cells. MATERIAL AND METHODS Cultured hPLDSCs were treated with different melatonin concentrations. The study groups were divided into 9 concentration-based groups: Group 1, untreated hPDLSCs; Group 2, hPDLSCs exposed to physiological doses of melatonin (1 μM); Group 3, hPDLSCs exposed to 10 μM melatonin; Group 4, hPDLSCs exposed to 20 μM melatonin; Group 5, hPDLSCs exposed to 30 μM melatonin; Group 6, hPDLSCs exposed to 40 μM melatonin; Group 7, hPDLSCs exposed to 50 μM melatonin; Group 8, hPDLSCs exposed to 100 μM melatonin; Group 9, hPDLSCs exposed to 150 μM melatonin. Cell viability was evaluated at 14 and 21 days using the AlamarBlue (AB) Cell Viability Assay, a toxicity assay. RESULTS Melatonin had a positive effect on hPDLSC viability in all test groups. A general pattern of decreasing cell viability with increasing melatonin concentrations was observed, with Groups 8 and 9 showing the lowest viability. An abrupt pattern was detected in Groups 4 and 7, where a sudden, significant increase in cell viability was observed, in contrast with the general observed pattern. CONCLUSIONS In conclusion, the hPDLSCs remained viable when exposed to the melatonin doses used, under osteogenic media, except for the 100µM and 150 µM melatonin groups. Therefore, further studies are required with hPDLSCs exposed to different concentrations of melatonin.
Enhanced Tumor Targeting with Midazolam-Loaded PLGA Nanoparticles: An In Vivo Analysis of Safety and Efficacy.
Jiao J, Ye L, Wang Y … +1 more , Li J
Med Sci Monit Basic Res · 2025 May · PMID 40405442 · Full text
BACKGROUND Midazolam, a commonly used sedative, faces challenges in cancer therapy due to its central nervous system (CNS) toxicity and suboptimal targeting of tumor sites. This study explores the use of poly (lactic-co-...
BACKGROUND Midazolam, a commonly used sedative, faces challenges in cancer therapy due to its central nervous system (CNS) toxicity and suboptimal targeting of tumor sites. This study explores the use of poly (lactic-co-glycolic acid) (PLGA) nanoparticles to enhance the delivery of Midazolam, aiming to improve antitumor efficacy while minimizing CNS toxicity. MATERIAL AND METHODS We developed Midazolam-loaded PLGA nanoparticles (Midazolam PLGA NPs) using the ultrasonic emulsification-solvent evaporation technique. These nanoparticles were thoroughly characterized for particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, drug loading, and stability. We assessed cellular uptake and cytotoxicity via the MTT assay, while organ accumulation was quantified using high-performance liquid chromatography-mass spectrometry (HPLC-MS). The safety profile was evaluated by monitoring body weight changes in A549 tumor-bearing mice. RESULTS The Midazolam PLGA nanoparticles exhibited a spherical shape, uniform size, high encapsulation efficiency, and excellent colloidal stability. In vitro release studies indicated that 62.51% of Midazolam was released within 24 hours. Enhanced cellular uptake was noted for the nanoparticles in comparison to the solution, with significant accumulation at tumor sites and increased free drug release. The nanoparticles effectively killed tumor cells while sparing normal tissues, demonstrating superior antitumor activity compared to the Midazolam solution. Importantly, treated mice maintained stable body weight, suggesting a favorable safety profile. CONCLUSIONS Midazolam-loaded PLGA nanoparticles present a promising approach for targeted cancer therapy. They enhance encapsulation, stability, and selective tumor cell cytotoxicity, resulting in greater antitumor efficacy with minimal adverse effects compared to conventional Midazolam solutions.
Adult Intussusception in Jordan: Demographics, Clinical Features, and Outcomes from a Tertiary Hospital.
Khasawneh RA, Khader YS, Gharaibeh MM … +5 more , Haj Hussein AA, Alkhaldi T, Igbariye Y, Khamaiseh D, Abd Elkhalik DM
Med Sci Monit Basic Res · 2024 Dec · PMID 39632476 · Full text
BACKGROUND Adult intussusception (AI) is a rare condition with diverse clinical presentations and management challenges. Despite its rarity, understanding its epidemiology, clinical features, and predictive factors disti...
BACKGROUND Adult intussusception (AI) is a rare condition with diverse clinical presentations and management challenges. Despite its rarity, understanding its epidemiology, clinical features, and predictive factors distinguishing benign and malignant lead points is crucial for effective management. This study aimed to assess the demographic and clinical characteristics of patients with pathological AI and examine factors associated with malignant lead points. MATERIAL AND METHODS Medical records of patients aged >18 years with diagnosis of AI between January 1, 2014, and January 1, 2024 were retrospectively analyzed. Patients were classified based on location and etiology of intussusception. Predictive factors for malignant lead points were assessed, including age, sex, presenting symptoms, location, and size of intussusception. Computed tomography (CT) scan images were reviewed for diagnosis confirmation. Transient small bowel intussusceptions and intussusceptions related to feeding tubes were excluded. RESULTS Twenty-six cases of pathological AI were identified over 10 years, with a male predominance (69.2%) and a mean age of 53.3 years. Abdominal pain was the most common presenting symptom (65.4%), with bowel obstruction diagnosed in 23.1% of cases. CT scans were the primary diagnostic modality (92.3%). Colocolic intussusceptions were most prevalent (53.8%), and surgical management was common (69.2%). Histopathological examination revealed benign lead points in the majority (57.7%) of cases, with lipomas and polyps being the most common. Bleeding per rectum was significantly associated with malignant lead points (P=0.011). CONCLUSIONS AI presents with diverse clinical features. It predominantly affects the colon. Bleeding per rectum indicates a higher likelihood of malignant lead points. A multidisciplinary approach is essential for optimal case-based management.
Correlation of Cytokine Profiles with Prostate-Specific Antigen and Disease Grade in Prostate Cancer.
Sulić J, Marijanović I, Kraljević M … +4 more , Šućur A, Kelava T, Mikulić I, Ćavar I
Med Sci Monit Basic Res · 2024 Nov · PMID 39568188 · Full text
BACKGROUND The development and progression of prostate cancer are multistep processes involving several growth factors, hormones, and cytokines. This study aimed to measure the serum concentrations of different cytokines...
BACKGROUND The development and progression of prostate cancer are multistep processes involving several growth factors, hormones, and cytokines. This study aimed to measure the serum concentrations of different cytokines and determine their correlation with prostate-specific antigen (PSA) levels and disease grade in patients with prostate adenocarcinoma. MATERIAL AND METHODS This cross-sectional study was conducted from March 2023 to March 2024 at the Clinic of Oncology of the University Hospital Center in Mostar, Bosnia and Herzegovina. Altogether, 50 male patients with prostate adenocarcinoma were included, of whom 28 had no proven metastases (PC group) and 22 had metastatic disease (MPC group). Serum concentrations of total (tPSA), free (fPSA), and complexed (cPSA) PSA were determined using a chemiluminescent microparticle immunoassay, whereas serum concentrations of cytokines were measured using a flow cytometry bead-based assay. RESULTS The MPC group had higher serum tPSA, fPSA, and cPSA levels than the PC group. The PC group had significantly higher serum levels of monocyte chemotactic protein (MCP)-1 than the MPC group (P=0.008). In the PC group, serum levels of interleukin (IL)-10 significantly correlated with cPSA. In the MPC group, serum concentrations of IL-1ß, tumor necrosis factor (TNF)-alpha, and IL-23 significantly correlated with disease grade. CONCLUSIONS Our study emphasizes the importance of MCP-1 in the development of prostate cancer, while IL-10 was the only cytokine whose serum level significantly correlated with cPSA. Serum concentrations of IL-1ß, TNF-alpha, and IL-23 may serve as potential biomarkers for disease grade.
Effect of Lidocaine on Ciprofol Dosage and Efficacy in Patients Who Underwent Gastroscopy Sedation.
Han Y, Zhang B, Jin L … +2 more , Yu Z, He H
Med Sci Monit Basic Res · 2024 Nov · PMID 39506303 · Full text
BACKGROUND Intravenous ciprofol is a short-acting sedative with minimal respiratory and circulatory suppression and limited analgesia. Intravenous lidocaine provides analgesia during surgical procedures. This study inclu...
BACKGROUND Intravenous ciprofol is a short-acting sedative with minimal respiratory and circulatory suppression and limited analgesia. Intravenous lidocaine provides analgesia during surgical procedures. This study included 70 patients who underwent gastroscopy with analgesia and aimed to evaluate the effects of intravenous lidocaine on the dose of ciprofol required to produce 50% of the maximal effect (ED50). MATERIAL AND METHODS Seventy patients scheduled for elective painless gastroscopy were randomly assigned into 2 groups: group L (n=35, received ciprofol and 1.5 mg/kg lidocaine) and group S (n=35, received ciprofol and normal saline). The primary outcomes measured were the ED50 and the 95% effective dose (ED95) of ciprofol, determined using the modified up-down sequential method and Probit analysis. Secondary outcomes included induction, operation, and recovery times; monitoring of vital signs such as mean arterial pressure, heart rate, and oxygen saturation; and evaluation of postoperative adverse reactions, including sore throat, nausea, vomiting, abdominal pain, and satisfaction scores from endoscopists and anesthesiologists. RESULTS The ED50 of ciprofol in group L was 0.315 mg/kg (95% CI, 0.291-0.342 mg/kg), which was significantly lower than that in group S, 0.42 mg/kg (95% CI, 0.371-0.491 mg/kg). Additionally, group L exhibited shorter induction and recovery times, a lower incidence of postoperative sore throat, and a temporary drop in blood pressure following induction. CONCLUSIONS Intravenous lidocaine during painless gastroscopy reduces the required ciprofol dose, shortens induction and recovery times, and lowers the incidence of postoperative complications, such as sore throat. These findings support its effective role in improving sedation quality and patient outcomes during gastroscopy.
Methods of Processing Dental Chromium-Cobalt Alloys for Production of Metal Frameworks Faced with Ceramics to Obtain the Best Mechanical Properties.
Wojciechowski I, Klatkiewicz T, Prylińska-Czyżewska A … +3 more , Borczyńska A, Jakubowska W, Pryliński M
Med Sci Monit Basic Res · 2024 Sep · PMID 39323082 · Full text
BACKGROUND Modern prosthetic technologies make it possible to fabricate prosthetic restorations without material loss and to make prosthetic restorations with complex geometric shapes in a relatively simple way. One such...
BACKGROUND Modern prosthetic technologies make it possible to fabricate prosthetic restorations without material loss and to make prosthetic restorations with complex geometric shapes in a relatively simple way. One such technology is selective laser melting (SLM), or additive manufacturing of metal materials, better known as 3D printing from metal or selective laser melting, but currently the most commonly used method is casting. The present study investigated use of dental chromium-cobalt alloys for prosthetic bridges and compared methods of processing dental chromium-cobalt alloys to obtain the best mechanical properties. MATERIAL AND METHODS We used dental chromium-cobalt alloy (SCHEFTNER GMBH) for laser melting StarbondCoSEeasy Powder with grain size of 10-30 µm and StarbondCoS alloy casting, made in accordance with the European standard EN ISO 22674. SLM-made specimens and induction melted alloy castings were prepared for the study. A centrifugal casting system with induction current melting of the metal alloy was used to produce the samples. The melting and casting process is automatic and limits changes in chemical composition. RESULTS The results show that none of the samples changed their chemical composition, while the samples made by SLM had better mechanical properties. CONCLUSIONS The SLM technique makes it possible to produce restorations faster and cheaper without any loss of quality compared to restorations made with the casting technique. Casting technology reduces mechanical properties, but still provides good mechanical properties.
A Comparison of Outcomes from Antibiotic Treatment with and without Probiotics in 897 Patients with Lower Urogenital Tract Infections, Including Cystitis, Urethritis, Prostatitis, and Vulvovaginitis.
Mula D, Dervishi R, Hoxha R … +5 more , Dervishi L, Gashi MM, Muçaj S, Muçaj E, Kuçi L
Med Sci Monit Basic Res · 2024 Jun · PMID 38918937 · Full text
BACKGROUND Urogenital bacterial infections have a high incidence in humans. The most frequent cause of infections of the urogenital tract is gram-negative bacteria. Antibiotics are very effective in curing infectious dis...
BACKGROUND Urogenital bacterial infections have a high incidence in humans. The most frequent cause of infections of the urogenital tract is gram-negative bacteria. Antibiotics are very effective in curing infectious diseases but they are accompanied by health complications. Probiotics are live microorganisms that are believed to confer a beneficial effect on human health when consumed in adequate amounts. This study aimed to compare outcomes from antibiotic treatment with and without the use of probiotics in 897 patients with lower urogenital tract infections, including cystitis, urethritis, prostatitis, and vulvovaginitis. MATERIAL AND METHODS A total of 897 patients aged 18 to 55 years were included in this research. Patients were divided into an intervention group including 460 patients (254 women, 206 men) and a comparison group including 437 patients (240 women, 197 men). The probiotics received by patients were capsules of ProBalans®. The diagnosis of cystitis, urethritis, prostatitis, vulvovaginitis, and sexually transmitted infection was done using several tests, and antibiotics were used for treatment. Qualitative data were analyzed using the chi-square or Fisher exact test. RESULTS We found a significant difference regarding patients' impressions of improvement after therapy between patients in the intervention group and the comparison group. CONCLUSIONS Use of probiotics together with antibiotics in the treatment of urogenital tract infection can help to reduce the adverse effects of antibiotics, increase the efficiency of antibiotic therapy, and reduce bacterial resistance to antibiotics. However, further research is needed to confirm these potential health benefits.
Questionnaire-Based Study of 392 Women in Abbottabad, Pakistan, to Evaluate the Types of Cosmetic Products Purchased Between December 2018 and March 2019 and Their Associated Adverse Events.
Nisar F, Ali A, Shahid H … +7 more , Iqbal MM, Khan H, Khan Q, Iqbal A, Samreen S, Syed W, Al-Rawi MBA
Med Sci Monit Basic Res · 2024 Mar · PMID 38549239 · Full text
BACKGROUND Cosmetics are applied topically to enhance appearance and are commonly used by women of all ages. Cosmetics contain many chemical agents, but the incidence of adverse reactions is low, possibly due to underrep...
BACKGROUND Cosmetics are applied topically to enhance appearance and are commonly used by women of all ages. Cosmetics contain many chemical agents, but the incidence of adverse reactions is low, possibly due to underreporting. This questionnaire-based study included 392 women to evaluate information on the types of cosmetics purchased between December 2018 and March 2019, their use by the women surveyed, and their associated adverse events. MATERIAL AND METHODS A cross-sectional study was conducted among 392 women in Abbottabad, Pakistan, using a pre-structured and validated questionnaire to evaluate information on the types of cosmetics, their use, and their associated adverse events. Part 1 of the study collected information about demographics. Part 2 contained a total of 11 items, and collected the frequency of use of cosmetic on skin and hair care products. Part 3 consisted of 4 items and collected information about problems encountered due to the use of cosmetics. RESULTS In the winter season, 47.7% (n=187) of women preferred chemical-based cosmetic products, while 30.9% (n=121) preferred Ayurvedic products. Among commonly used cosmetic products, 26.9% (n=106) of women used foundations. The most frequently used skin care product was face wash 39.5% (n=155). The most prevalent adverse events related to cosmetics were pimples (19.9%, n=78), redness (17.6%, n=69), and eye discomfort (15.8%, n=62). Furthermore, 51.3% (n=201) strongly agreed that cosmetics aid in getting a whiter complexion. CONCLUSIONS The survey concluded that most women preferred cosmetics with a chemical base, which are associated with rashes, redness, and acne. It is important to encourage cosmetovigilance and awareness campaigns among cosmetic product sellers and users.
Levels of Depression, Anxiety, and Stress Among Saudi Arabia's Medical and Dental Practitioners: A Cross-Sectional Study Following the Covid-19 Pandemic.
Jabali AH, Chourasia HR, Tarrosh MY … +5 more , Alhazmi YA, Aljabri MY, Chourasia UH, Hakami A, Alroomy R
Med Sci Monit Basic Res · 2024 Mar · PMID 38425038 · Full text
BACKGROUND Healthcare providers, particularly in dentistry and medicine, experience high stress levels, exacerbated by factors like patient anxiety, clinical work, and continuous training. The COVID-19 pandemic has furth...
BACKGROUND Healthcare providers, particularly in dentistry and medicine, experience high stress levels, exacerbated by factors like patient anxiety, clinical work, and continuous training. The COVID-19 pandemic has further increased these risks. This study aimed to assess depression, anxiety, and stress (DAS) among dental and medical practitioners in Saudi Arabia, investigating influential factors on their psychological behavior. MATERIAL AND METHODS In this cross-sectional study conducted in July and August 2021, the depression, anxiety, and stress scale (DASS-21) was administered through a Google questionnaire. Data analysis involved stepwise mode modeling and bivariate analysis, with a significant P value <0.05, using the Statistical Package for the Social Sciences. RESULTS The study included 376 dentists and 201 medical practitioners. Most worked more than four days a week, slept under six hours nightly, and were non-smokers. DAS scores indicated depression (51.7-57.4%), anxiety (50.7-58.2%), and stress (54.2-60.1%). Significant differences (P<0.05) were observed among younger, single, female, and lower-income participants. Higher DAS scores correlated with less sleep, extensive social media use, and smoking history. Socio-demographic factors were mostly non-significant for medical practitioners, except social media use. Sleep duration significantly impacted stress levels, while specialty, income, and marital status influenced depression CONCLUSIONS DAS levels were notably higher in dentists compared to medical practitioners, particularly regarding anxiety. The impact of socioeconomic factors varied, being more statistically significant for dentists.
Evaluation of the Effects of Digital Manufacturing, Preparation Taper, Cement Type, and Aging on the Color Stability of Anterior Provisional Crowns Using Colorimetry.
Sayed ME, Lunkad H, Mattoo K … +11 more , Jokhadar HF, AlResayes SS, Alqahtani NM, Alshehri AH, Alamri M, Altowairqi S, Muaddi M, Huthan HM, Baeshen SA, Motlaq K, Masmali AM
Med Sci Monit Basic Res · 2023 Nov · PMID 37987528 · Full text
BACKGROUND Replicating the 3-dimensional (3D) color of natural teeth in artificial substitutes is challenging. Fixed dental prosthodontics require aesthetic, color-stable provisional restorations. Recent milling and 3D p...
BACKGROUND Replicating the 3-dimensional (3D) color of natural teeth in artificial substitutes is challenging. Fixed dental prosthodontics require aesthetic, color-stable provisional restorations. Recent milling and 3D printing digital manufacturing techniques offer improved outcomes. This study assesses color stability in various digital manufacturing methods, tapers, and aging effects on anterior provisional resin restorations. MATERIAL AND METHODS Two all-ceramic tooth preparations on typodont teeth with 10° and 20° tapers were converted into experimental dies. Forty temporary crowns were manufactured using 3D printing and computer-aided design/computer-aided manufacturing (milling). Within these 2 groups, 10 crowns were cemented using a regular and clear provisional cement. All samples were thermocycled to simulate clinical use of 6 months. Color difference formula (CIEDE2000) indicated changes between before and after cementation (ΔE00) and between after cementation and after thermocycling (ΔE00[II]). The color change was considered significant in terms of clinically perceptible (ΔE00 ≤0.62) and acceptable (ΔE00 ≤2.62) changes. One-way ANOVA (P value of less than 0.05) calculated overall differences, which were established using a Fisher post hoc test. RESULTS Crowns cemented with clear cement showed fewer color changes irrespective of the manufacturing technique or taper. Notably, only the 10° 3D-printed crown with clear cement had an imperceptible color change at the pre-/post-cementation phase. Meanwhile, the 10° and 20° milled crowns with regular cement exhibited unacceptable color changes after thermocycling. CONCLUSIONS For long‑term temporization in the aesthetic zone, properly optimized 3D-printed provisional restorations cemented with clear cement had better color stability.
Urinary Klotho Excretion: A Key Regulator of Sodium Homeostasis in Chronic Kidney Disease Stage 2-4.
Chi PJ, Lee CJ, Hung SY … +2 more , Tsai JP, Liou HH
Med Sci Monit Basic Res · 2023 Nov · PMID 37987256 · Full text
BACKGROUND Soluble alpha-klotho (klotho) is considered an important regulator of mineral homeostasis in patients with chronic kidney disease (CKD). Since the mineral transport proteins are located on the apical membrane...
BACKGROUND Soluble alpha-klotho (klotho) is considered an important regulator of mineral homeostasis in patients with chronic kidney disease (CKD). Since the mineral transport proteins are located on the apical membrane of renal tubular cells, we hypothesized that urine klotho may also be involved in their homeostasis. We aimed to investigate the associations between serum and urine klotho and their impacts on mineral homeostasis in patients with stage 2 to 4 CKD. MATERIAL AND METHODS Serum, spot urine, and 24-h urine of klotho were measured by using enzyme-linked immunosorbent assay. Fractional excretion of sodium, potassium, calcium, phosphate, magnesium, and klotho were calculated. RESULTS A total of 53 patients with CKD stages 2 to 4 were enrolled in this cross-sectional study. The mean age was 71.1±10.5 years, and 68% were men. Linear regression analysis showed that serum log-transformed klotho was negatively associated with log-transformed fractional excretion of klotho (log-FEKlotho) (ß=-0.085, P=0.02), showing that urinary klotho excretion could negatively regulate serum klotho levels. Moreover, our multivariate stepwise regression showed log-fractional excretion of sodium was positively associated with log-FEKlotho (ß=0.138, P=0.032). This implied urinary klotho excretion positively regulated urinary sodium excretion. CONCLUSIONS Our study showed that urine klotho excretion resulted in decreased serum klotho levels and enhanced urinary sodium excretion in patients with CKD stages 2 to 4. In addition to serum klotho, we found, for the first time, that urine klotho also played a significant role in sodium homeostasis.
Exploring the Impact of the COVID-19 Pandemic on Academic Burnout Among Nursing College Students in China: A Web-Based Survey.
Liu H, Zhang Z, Chi C … +2 more , Tao X, Zhang M
Med Sci Monit Basic Res · 2023 Oct · PMID 37963323 · Full text
BACKGROUND The COVID-19 pandemic has brought changes and challenges to nursing students. However, little is known about the prevalence of academic burnout among nursing students in this challenging circumstance. This stu...
BACKGROUND The COVID-19 pandemic has brought changes and challenges to nursing students. However, little is known about the prevalence of academic burnout among nursing students in this challenging circumstance. This study aimed to assess nursing student academic burnout and its influencing factors. MATERIAL AND METHODS We conducted a sample survey of a 4-year undergraduate nursing university in Wuhu, Anhui Province, China. The social-demographic information questionnaire, Academic Burnout Scale, Connor-Davidson Resilience Scale, Impact of Event Scale-6, Patient Health Questionnaire-2, and Professional Identity Scale were used. Stepwise multiple linear regression was used to clarify the relationship among sociodemographic characteristics, resilience, and academic burnout. RESULTS Of all the study participants, 51.30% had a certain degree of academic burnout. Academic year, satisfaction with specialty, satisfaction with online learning, professional identity, and psychological resilience were negatively correlated with academic burnout among nursing students. Depression was positively correlated with academic burnout. CONCLUSIONS Nursing students had a high degree of academic burnout. Academic year, satisfaction with specialty, satisfaction with online learning, professional identity, and psychological resilience were protective factors that reduced nursing students' academic burnout.
Anxiety and Depression Survey and Analysis of Hospital Staff in a Designated Hospital in Shannan City During the COVID-19 Pandemic.
Zhang P, Tang L, Ciren D
Med Sci Monit Basic Res · 2023 May · PMID 37248731 · Full text
BACKGROUND The aim of this study was to evaluate the psychological status of anxiety and depression of hospital staff in the designated hospital in the city of Shannan during the COVID-19 pandemic in order to provide a t...
BACKGROUND The aim of this study was to evaluate the psychological status of anxiety and depression of hospital staff in the designated hospital in the city of Shannan during the COVID-19 pandemic in order to provide a theoretical basis for effective psychological intervention. MATERIAL AND METHODS A cross-sectional survey was performed from September 10 to 16, 2022, by administering an online questionnaire to the hospital staff on duty in the hospital. We collected participants' demographic and general information. The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to investigate the anxiety and depression of hospital staff. RESULTS Among 267 hospital staff, anxiety was found in 98 individuals, with a prevalence of 36.70%. Depression was found in 170 individuals, with a prevalence of 63.67%. Anxiety combined with depression was found in 84 individuals, with a prevalence of 31.46%. The prevalence of depression was higher in women, Tibetan personnel, hospital staff with primary or lower titles, staff without career establishment, and non-aid Tibetan personnel, and the differences were all statistically significant (P.
A Questionnaire-Based Study to Compare the Psychological Effects of 6 Weeks of Exercise in 123 Chinese College Students.
Wei MX, Liu Z
Med Sci Monit Basic Res · 2023 Mar · PMID 37022969 · Full text
BACKGROUND The aim of this study was to explore the mechanisms underlying the association between exercise intervention and mental health, and our questionnaire-based study aimed to compare the psychological effects of 6...
BACKGROUND The aim of this study was to explore the mechanisms underlying the association between exercise intervention and mental health, and our questionnaire-based study aimed to compare the psychological effects of 6 weeks of exercise among 123 Chinese university students. MATERIAL AND METHODS A total of 123 college students were randomly divided into the experimental group (80 patients) and the control group (43 patients). The experimental group participated in a 6-week exercise intervention, and the control group received no intervention. Questionnaires were used to study emotion regulation and mental health. RESULTS The exercise intervention has a significant effect on reducing the anxiety and depression levels of college students [F(1,122)=10.83, p.
Study of 60 Adult Patients to Compare Standard Postoperative Clinical Assessment with Train-of-Four Ratio ≥0.9 on Patient Outcomes Using Postoperative Spirometry and Neuromuscular Function Measurements Following Extubation.
Chen C, Liu Q, Fan H … +4 more , Yu Z, Leng X, Zhang L, Zhou Z
Med Sci Monit Basic Res · 2023 Mar · PMID 36883230 · Full text
BACKGROUND Postoperative tracheal extubation requires optimal timing to ensure patient safety and normal muscle function. The train-of-four ratio (TOFR) of the fourth muscle response compared with the first indicates a n...
BACKGROUND Postoperative tracheal extubation requires optimal timing to ensure patient safety and normal muscle function. The train-of-four ratio (TOFR) of the fourth muscle response compared with the first indicates a non-depolarizing neuromuscular block, and a ratio ≥0.9 can be used as an objective measurement of neuromuscular reversal. This study of 60 adult patients who underwent elective surgery with general anesthesia that included the neuromuscular blocking agent cisatracurium aimed to compare standard postoperative clinical assessment with the TOFR ≥0.9 on patient outcomes using postoperative neuromuscular function assessed by grip strength and ability to sit up unaided and spirometry measurements following extubation. MATERIAL AND METHODS The 30 patients extubated postoperatively in the TOF group were required to have a TOFR ≥0.9, while the 30 patients in the clinical assessment group were awake and following simple commands and had a 5-second head lift and spontaneous breathing with acceptable oxygenation. The main outcomes were the incentive spirometry and grip strength and ability to sit up unaided measured at 10, 30, 50 min and 24 h after extubation. RESULTS The groups had no difference in recovery path of incentive spirometry volume (P=0.072) and no difference in postoperative incentive spirometry decrease from baseline except at 10 min after extubation (P=0.005). There was no difference in handgrip strength and independent sitting between groups. CONCLUSIONS The findings showed that using the TOF ratio ≥0.9 before extubation did not improve early postoperative strength quantified by spirometry volume, handgrip strength, and proportion of unaided sitting.
A Prospective Study of 73 Patients to Compare Forward Head Angle, Forward Shoulder Angle, Maximal Inspiratory Pressure, and Self-Reported Breathing-Related Symptoms Before and After Open-Heart Surgery.
Thanasarn B, Pibul W, Kulchanarat C … +2 more , Piathip D, Yuenyongchaiwat K
Med Sci Monit Basic Res · 2023 Feb · PMID 36849799 · Full text
BACKGROUND Patients who undergo open-heart surgery often experience widespread musculoskeletal and pulmonary complications. These can interfere with their functioning, resulting in soft tissue changes, worsening postural...
BACKGROUND Patients who undergo open-heart surgery often experience widespread musculoskeletal and pulmonary complications. These can interfere with their functioning, resulting in soft tissue changes, worsening postural changes, and poor respiratory performance. Therefore, the prospective study aimed to compare forward head angle (FHA) and forward shoulder angle (FSA), maximal inspiratory pressure (MIP), and self-reported breathing dysfunction before and after open-heart surgery. MATERIAL AND METHODS In a prospective observational study of 106 patients, men and women scheduled for open-heart surgery were enrolled. Prior to surgery and before discharge from the hospital, all patients were required to assess FHA and FSA using 2-dimensional motion analysis software, MIP using a respiratory pressure meter, and breathing dysfunction using the 25-item Self Evaluation of Breathing Questionnaire (SEBQ). Paired t test was used to compare differences between before and after surgery. To evaluate associations, logistic regression analysis was performed. RESULTS Of the 106 patients recruited, 73 completed the study. FHA (-Δ6.55±4.77, P.
Prevalence and Associated Factors of Depression Among Frontline Nurses in Wuhan 6 Months After the Outbreak of COVID-19: A Cross-Sectional Study.
Liu H, Zhou Z, Liu Y … +3 more , Tao X, Zhan Y, Zhang M
Med Sci Monit Basic Res · 2023 Jan · PMID 36849512 · Full text
BACKGROUND Due to the COVID-19 pandemic, frontline nurses have experienced psychological problems. However, the depression of frontline nurses in Wuhan 6 months after the outbreak of COVID-19 has not been studied adequat...
BACKGROUND Due to the COVID-19 pandemic, frontline nurses have experienced psychological problems. However, the depression of frontline nurses in Wuhan 6 months after the outbreak of COVID-19 has not been studied adequately. The purpose of this study was to investigate the depression of frontline nurses in Wuhan 6 months after the COVID-19 outbreak and to analyze possible risk and protective factors. MATERIAL AND METHODS Data were collected through Wenjuanxing from 612 frontline nurses in Wuhan national COVID-19-designated hospitals between July 27, 2020, and August 12, 2020. The levels of depression, family functioning, and psychological resilience were assessed among frontline nurses in Wuhan with a depression scale, family function scale, and 10-item psychological resilience scale, respectively. The factors associated with depressive symptoms were identified using the chi-square test and binary logistic regression analysis. RESULTS A total of 126 respondents were included in the study. The overall prevalence of depression was 25.2%. The need for mental health services was a potential risk factor for depressive symptoms, while family functioning and psychological resilience were potential protective factors. The COVID-19 pandemic poses a major challenge to the depressive symptoms of frontline nursing in Wuhan, highlighting the need for all frontline nurses in Wuhan to be screened for depression regularly for timely intervention. CONCLUSIONS To mitigate the impact of the pandemic on depression, psychological interventions for frontline nurses need to be implemented to preserve their mental health.
Use of Estimated Glomerular Filtration Rate and Urine Albumin-to-Creatinine Ratio Based on KDIGO 2012 Guideline in a Thai Community Hospital: Prevalence of Chronic Kidney Disease and its Risk Factors.
Lekskulchai V
Med Sci Monit Basic Res · 2022 Dec · PMID 36542497 · Full text
BACKGROUND Kidney disease is hard to detect at its early stage; therefore, the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guideline was developed for improving care and outcomes of patients with kidney diseas...
BACKGROUND Kidney disease is hard to detect at its early stage; therefore, the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guideline was developed for improving care and outcomes of patients with kidney disease. This study aimed to determine clinical outcomes from applying this guideline in a community hospital service. MATERIAL AND METHODS The patients' data were extracted from their medical records and analyzed for outcomes of using the estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) for detecting kidney disease. RESULTS The eGFR was utilized in 36 172 patients aged ≥18 years, and 76.86% of them had normal kidney function. The prevalence of chronic kidney disease (CKD) was 8.20%; most patients (68%) with CKD were in stages 3a and 3b. The most common causes of CKD were diabetes and hypertension. The UACR was mainly used in patients with diabetes. The percentage of patients with UACR ≥3 mg/mmol creatinine alone was significantly higher than that of patients with eGFR.
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