Svalina MN, Sullivan R, Restrepo D
… +1 more, Huntsman MM
Front Integr Neurosci
· 2023 · PMID 36969493
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Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the gene resulting in transcriptional silencing and loss of function of fragile X messenger ribon...Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early development of the brain. Thus, loss of the FMRP has well-known consequences for normal cellular and synaptic development leading to a variety of neuropsychiatric disorders including an increased prevalence of amygdala-based disorders. Despite our detailed understanding of the pathophysiology of FXS, the precise cellular and circuit-level underpinnings of amygdala-based disorders is incompletely understood. In this review, we discuss the development of the amygdala, the role of neuromodulation in the critical period plasticity, and recent advances in our understanding of how synaptic and circuit-level changes in the basolateral amygdala contribute to the behavioral manifestations seen in FXS.
Loso H, Chaarani B, Dube SL
… +4 more, Albaugh MD, Cheaito A, Garavan H, Potter A
Front Integr Neurosci
· 2023 · PMID 36969492
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INTRODUCTION: Stressful childhood experiences are associated with unique brain activity patterns during emotional processing. Specifically, pediatric stress is linked to activation in the insulae, superior temporal and p...INTRODUCTION: Stressful childhood experiences are associated with unique brain activity patterns during emotional processing. Specifically, pediatric stress is linked to activation in the insulae, superior temporal and parahippocampal gyri, and the amygdalae, as well as differential activation in the dorsal anterior cingulate cortex when viewing emotional faces. Gender diversity is broadly associated with higher victimization and mental health disparities in children aged 9/10, but whether it is associated with stress-like alterations in brain function (BOLD signal during task-based fMRI) remains unknown. We investigate the functional brain correlates of this relationship to determine if gender-diverse youth show patterns of functional activity during an emotional task consistent with those of other populations that experience heightened stress. METHODS: We used data from the Adolescent Brain Cognitive Development (ABCD) study. First, we identified a subset of 4,385 participants aged 10/11 years with gender diversity data and quality-controlled fMRI data from the EN-Back (emotional -back) task. The EN-Back is a working memory task that presents emotion faces as well as pictures of places as control stimuli. We regressed BOLD signal associated with emotion faces (faces minus places contrast) on gender diversity. Next, we tested if parental acceptance or youth perceptions of their school environment moderated the relationship between gender diversity and activation in the insulae or fusiform gyrus. Finally, we used structural equation modeling to investigate gender diversity's association with parental acceptance, perceptions of school environments, internalizing and externalizing problems. RESULTS: Gender diversity was associated with widespread increases in BOLD signal during the faces condition of the EN-Back task. Youth's report of parental acceptance and school environment did not moderate the relationship between gender diversity and BOLD signal in the insula or fusiform gyrus. Gender diversity was related to greater parent and school-related stress, which was associated with elevated mental health problems. CONCLUSION: Patterns of functional activity were consistent with those reported in prior literature on childhood stress. Gender diversity was associated with increased emotional and behavioral problems, as well as parent and school-related stress. These findings indicate the importance of the home and school environments for supporting the wellbeing of gender diverse youth.
Front Integr Neurosci
· 2023 · PMID 36959924
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Recent research has illuminated the complexity and importance of the thalamocortical system but it has been difficult to identify what computational functions it performs. Meanwhile, deep-learning artificial neural netwo...Recent research has illuminated the complexity and importance of the thalamocortical system but it has been difficult to identify what computational functions it performs. Meanwhile, deep-learning artificial neural networks (ANNs) based on bio-inspired models of purely cortical circuits have achieved surprising success solving sophisticated cognitive problems associated historically with human intelligence. Nevertheless, the limitations and shortcomings of artificial intelligence (AI) based on such ANNs are becoming increasingly clear. This review considers how the addition of thalamocortical connectivity and its putative functions related to cortical attention might address some of those shortcomings. Such bio-inspired models are now providing both testable theories of biological cognition and improved AI technology, much of which is happening outside the usual academic venues.
Doherty EJ, Spencer CA, Burnison J
… +12 more, Čeko M, Chin J, Eloy L, Haring K, Kim P, Pittman D, Powers S, Pugh SL, Roumis D, Stephens JA, Yeh T, Hirshfield L
Front Integr Neurosci
· 2023 · PMID 36922983
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Functional Near-Infrared Spectroscopy (fNIRS) is an innovative and promising neuroimaging modality for studying brain activity in real-world environments. While fNIRS has seen rapid advancements in hardware, software, an...Functional Near-Infrared Spectroscopy (fNIRS) is an innovative and promising neuroimaging modality for studying brain activity in real-world environments. While fNIRS has seen rapid advancements in hardware, software, and research applications since its emergence nearly 30 years ago, limitations still exist regarding all three areas, where existing practices contribute to greater bias within the neuroscience research community. We spotlight fNIRS through the lens of different end-application users, including the unique perspective of a fNIRS manufacturer, and report the challenges of using this technology across several research disciplines and populations. Through the review of different research domains where fNIRS is utilized, we identify and address the presence of bias, specifically due to the restraints of current fNIRS technology, limited diversity among sample populations, and the societal prejudice that infiltrates today's research. Finally, we provide resources for minimizing bias in neuroscience research and an application agenda for the future use of fNIRS that is equitable, diverse, and inclusive.
Front Integr Neurosci
· 2023 · PMID 36908504
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The interplay between different modalities can help to perceive stimuli more effectively. However, very few studies have focused on how multisensory distractors affect task performance. By adopting behavioral and event-r...The interplay between different modalities can help to perceive stimuli more effectively. However, very few studies have focused on how multisensory distractors affect task performance. By adopting behavioral and event-related potentials (ERPs) techniques, the present study examined whether multisensory audiovisual distractors could attract attention more effectively than unisensory distractors. Moreover, we explored whether such a process was modulated by working memory load. Across three experiments, n-back tasks (1-back and 2-back) were adopted with peripheral auditory, visual, or audiovisual distractors. Visual and auditory distractors were white discs and pure tones (Experiments 1 and 2), pictures and sounds of animals (Experiment 3), respectively. Behavioral results in Experiment 1 showed a significant interference effect under high working memory load but not under low load condition. The responses to central letters with audiovisual distractors were significantly slower than those to letters without distractors, while no significant difference was found between unisensory distractor and without distractor conditions. Similarly, ERP results in Experiments 2 and 3 showed that there existed an integration only under high load condition. That is, an early integration for simple audiovisual distractors (240-340 ms) and a late integration for complex audiovisual distractors (440-600 ms). These findings suggest that multisensory distractors can be integrated and effectively attract attention away from the main task, i.e., interference effect. Moreover, this effect is pronounced only under high working memory load condition.
Zhang J, He Z, Liu L
… +7 more, Li H, Wang T, Zhu X, Wang Y, Zhu D, Ning Y, Xu Y
Front Integr Neurosci
· 2023 · PMID 36896253
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The aim of this study is to interrogate the prophylactic effect of probiotic on the lead-induced spatial memory impairment, as well as the underlying mechanisms based on gut microbiota. Rats were exposed postnatally to...The aim of this study is to interrogate the prophylactic effect of probiotic on the lead-induced spatial memory impairment, as well as the underlying mechanisms based on gut microbiota. Rats were exposed postnatally to 100 ppm of lead acetate during lactation (from postnatal day 1 to 21), to establish the memory deficits model. A probiotic bacterium, namely , was administered by drinking into pregnant rats with a dosage of 10 CFU/rat/day till birth. At postnatal week 8 (PNW8), the rats were subjected to Morris water maze and Y-maze test, with fecal samples collected for 16S rRNA sequencing. Besides, the inhibitory effect of on was carried out in bacterial co-culture. Female rats prenatally exposed to probiotic improved their performances in the behavioral test, indicating that probiotic could protect rats from memory deficits caused by postnatal lead exposure. This bioremediation activity varies depending on the intervention paradigm used. As revealed by microbiome analysis, although administered in a distinct period from lead exposure, further changed the microbial structure disrupted by lead exposure, suggesting an effective transgenerational intervention. Of note, gut microbiota, represented by Bacteroidota, varied greatly depending on the intervention paradigm as well as the developmental stage. The concerted alterations were revealed between some keystone taxa and behavioral abnormality, including lactobacillus and . To this end, an co-culture was created to demonstrate that could inhibit the growth of with direct contact, which is dependent on the growth condition under study. In addition, infection of O157 aggravated memory dysfunction, which could also be rescued by probiotic colonization. Early probiotic intervention could prevent organisms from lead-induced memory decline in later life through reprogramming gut microbiota and inhibiting , providing a promising approach to ameliorate the cognitive damage with environmental origins.
Kong Q, Chen LM, Dai ZH
… +5 more, Tang YZ, Zhou YY, Tu WZ, Zhao YH, Zhang JQ
Front Integr Neurosci
· 2023 · PMID 36864895
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OBJECTIVE: Care patterns and Traditional Chinese Medicine (TCM) constitution affects the emotion and health of patients with systemic sclerosis (SSc) while the prevalence of COVID-19 may aggravate such patients' emotion...OBJECTIVE: Care patterns and Traditional Chinese Medicine (TCM) constitution affects the emotion and health of patients with systemic sclerosis (SSc) while the prevalence of COVID-19 may aggravate such patients' emotion and health. We investigated the depression and anxiety levels of patients with SSc during the pandemic to identify the correlation between care patterns, TCM constitution, and patients' emotion. MATERIALS AND METHODS: This was a cross-sectional study. Patients with SSc and healthy individuals were surveyed using the patient health questionnaire-9, generalized anxiety disorder-7, and constitution in Chinese medicine questionnaire and a modified care pattern questionnaire. Factors correlated with depression and anxiety were screened using univariate and multivariate logistic regression analyses. RESULTS: A total of 273 patients with SSc and 111 healthy individuals were included in the analysis. The proportion of patients with SSc who were depressed was 74.36%, who had anxiety was 51.65%, and who experienced disease progression during the pandemic was 36.99%. The proportion of income reduction in the online group (56.19%) was higher than that in the hospital group (33.33%) ( = 0.001). Qi-deficiency [adjusted odds ratio (OR) = 2.250] and Qi-stagnation (adjusted OR = 3.824) constitutions were significantly associated with depression. Remote work during the outbreak (adjusted OR = 1.920), decrease in income (adjusted OR = 3.556), and disease progression ( = 0.030) were associated with the occurrence of depression. CONCLUSION: Chinese patients with SSc have a high prevalence of depression and anxiety. The COVID-19 pandemic has changed the care patterns of Chinese patients with SSc, and work, income, disease progression, and change of medications were correlates of depression or anxiety in patients with SSc. Qi-stagnation and Qi-deficiency constitutions were associated with depression, and Qi-stagnation constitution was associated with anxiety in patients with SSc. TRIAL REGISTRATION: http://www.chictr.org.cn/showproj.aspx?proj=62301, identifier ChiCTR2000038796.
Hill-Jarrett TG, Ng R, Cardenas-Iniguez C
… +17 more, Akinsanya J, Blanco I, Borland JM, Brown JS, Clemons T, Cushnie AK, Garcia J, George B, Hassinan CW, Hines TJ, Landayan D, McCorkle TA, Meckel KR, Metcalfe M, Montoya SA, Rose DK, Warren DR
Front Integr Neurosci
· 2023 · PMID 36845406
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Many early-career neuroscientists with diverse identities may not have mentors who are more advanced in the neuroscience pipeline and have a congruent identity due to historic biases, laws, and policies impacting access...Many early-career neuroscientists with diverse identities may not have mentors who are more advanced in the neuroscience pipeline and have a congruent identity due to historic biases, laws, and policies impacting access to education. Cross-identity mentoring relationships pose challenges and power imbalances that impact the retention of diverse early career neuroscientists, but also hold the potential for a mutually enriching and collaborative relationship that fosters the mentee's success. Additionally, the barriers faced by diverse mentees and their mentorship needs may evolve with career progression and require developmental considerations. This article provides perspectives on factors that impact cross-identity mentorship from individuals participating in Diversifying the Community of Neuroscience (CNS)-a longitudinal, National Institute of Neurological Disorders and Stroke (NINDS) R25 neuroscience mentorship program developed to increase diversity in the neurosciences. Participants in Diversifying CNS were comprised of 14 graduate students, postdoctoral fellows, and early career faculty who completed an online qualitative survey on cross-identity mentorship practices that impact their experience in neuroscience fields. Qualitative survey data were analyzed using inductive thematic analysis and resulted in four themes across career levels: (1) approach to mentorship and interpersonal dynamics, (2) allyship and management of power imbalance, (3) academic sponsorship, and (4) institutional barriers impacting navigation of academia. These themes, along with identified mentorship needs by developmental stage, provide insights mentors can use to better support the success of their mentees with diverse intersectional identities. As highlighted in our discussion, a mentor's awareness of systemic barriers along with active allyship are foundational for their role.
Norris JE, Schmitt LM, De Stefano LA
… +4 more, Pedapati EV, Erickson CA, Sweeney JA, Ethridge LE
Front Integr Neurosci
· 2023 · PMID 36816716
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INTRODUCTION: Fragile X Syndrome (FXS) is rare genetic condition characterized by a repeat expansion (CGG) in the Fragile X messenger ribonucleoprotein 1 (FMR1) gene where individuals with greater than 200 repeats are de...INTRODUCTION: Fragile X Syndrome (FXS) is rare genetic condition characterized by a repeat expansion (CGG) in the Fragile X messenger ribonucleoprotein 1 (FMR1) gene where individuals with greater than 200 repeats are defined as full mutation. FXS clinical presentation often includes intellectual disability, and autism-like symptoms, including anxiety and sensory hypersensitivities. Individuals with 55 to <200 CGG repeats are said to have the FMR1 premutation, which is not associated with primary characteristics of the full mutation, but with an increased risk for anxiety, depression, and other affective conditions, as well as and impaired cognitive processing differences that vary in severity. Defining subgroups of premutation carriers based on distinct biological features may identify subgroups with varying levels of psychiatric, cognitive, and behavioral alterations. METHODS: The current pilot study utilized 3 cluster subgroupings defined by previous k means cluster analysis on neuropsychiatric, cognitive, and resting EEG variables in order to examine basic sensory auditory chirp task-based EEG parameters from 33 females with the FMR1 premutation (ages 17-78). RESULTS: Based on the predefined, neuropsychiatric three-cluster solution, premutation carriers with increased neuropsychiatric features and higher CGG repeat counts (cluster 1) showed decreased stimulus onset response, similar to previous ERP findings across a number of psychiatric disorders but opposite to findings in individuals with full mutation FXS. Premutation carriers with increased executive dysfunction and resting gamma power (cluster 2) exhibited decreased gamma phase locking to a chirp stimulus, similar to individuals with full mutation FXS. Cluster 3 members, who were relatively unaffected by psychiatric or cognitive symptoms, showed the most normative task-based EEG metrics. DISCUSSION: Our findings suggest a spectrum of sensory processing characteristics present in subgroups of premutation carriers that have been previously understudied due to lack of overall group differences. Our findings also further validate the pre-defined clinical subgroups by supporting links between disturbances in well-defined neural pathways and behavioral alterations that may be informative for identifying the mechanisms supporting specific risk factors and divergent therapeutic needs in individuals with the FMR1 premutation.
Front Integr Neurosci
· 2022 · PMID 36743477
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BACKGROUND: Neurobiological models to explain the vulnerability of autism spectrum disorders (ASDs) are scarce, and previous resting-state functional magnetic resonance imaging (rs-fMRI) studies mostly examined static fu...BACKGROUND: Neurobiological models to explain the vulnerability of autism spectrum disorders (ASDs) are scarce, and previous resting-state functional magnetic resonance imaging (rs-fMRI) studies mostly examined static functional connectivity (FC). Given that FC constantly evolves, it is critical to probe FC dynamic differences in ASD patients. METHODS: We characterized recurring phase-locking (PL) states during rest in 45 ASD patients and 47 age- and sex-matched healthy controls (HCs) using Leading Eigenvector Dynamics Analysis (LEiDA) and probed the organization of PL states across different fine grain sizes. RESULTS: Our results identified five different groups of discrete resting-state functional networks, which can be defined as recurrent PL state overtimes. Specifically, ASD patients showed an increased probability of three PL states, consisting of the visual network (VIS), frontoparietal control network (FPN), default mode network (DMN), and ventral attention network (VAN). Correspondingly, ASD patients also showed a decreased probability of two PL states, consisting of the subcortical network (SUB), somatomotor network (SMN), FPN, and VAN. CONCLUSION: Our findings suggested that the temporal reorganization of brain discrete networks was closely linked to sensory to cognitive systems of the brain. Our study provides new insights into the dynamics of brain networks and contributes to a deeper understanding of the neurological mechanisms of ASD.
Chen Z, Liu X, Miao K
… +4 more, Liao X, Zhang X, Feng Z, Chuan-Peng H
Front Integr Neurosci
· 2022 · PMID 36714201
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Preface illustration. The "first-last-author-credit" hierarchy has long been dominated in the scientific incentive system despite intensive calling for contribution-based credits (author contribution statement). In the s...Preface illustration. The "first-last-author-credit" hierarchy has long been dominated in the scientific incentive system despite intensive calling for contribution-based credits (author contribution statement). In the scientific communities, senior researchers would still make a decision to recommend one's promotion based on first and last positions in authorship rather than their contributions. Similarly, in the job market, institutions would acknowledge one's credit by positions in authorship in a study for faculty recruitment, while overlooking the author contribution statement at the end of studies. Thus, the current authorship system has brought on the risks underlying authorship disputes and race/gender inequalities in credit allocation heavily, especially for early career researchers and female scientists. In addition, this is one of the major barriers to extend teamwork and academic collaboration. On the contrary, scrambling for first and last positions leads to prominent credit inflation-that is to be observed-the number of co-first and co-corresponding authors has been increasing dramatically. Thus, we shall propose a new contributionship to acknowledge the author's credit for an open science and quantitative framework to tackle these issues. Credit: ZC and XRL.
Front Integr Neurosci
· 2022 · PMID 36704759
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Cingulotomy is therapeutic in OCD, but what are the possible mechanisms? Computer models that formalize cortical OCD abnormalities and anterior cingulate cortex (ACC) function can help answer this. At the neural dynamics...Cingulotomy is therapeutic in OCD, but what are the possible mechanisms? Computer models that formalize cortical OCD abnormalities and anterior cingulate cortex (ACC) function can help answer this. At the neural dynamics level, cortical dynamics in OCD have been modeled using attractor networks, where activity patterns resistant to change denote the inability to switch to new patterns, which can reflect inflexible thinking patterns or behaviors. From that perspective, cingulotomy might reduce the influence of difficult-to-escape ACC attractor dynamics on other cortical areas. At the functional level, computer formulations based on model-free reinforcement learning (RL) have been used to describe the multitude of phenomena ACC is involved in, such as tracking the timing of expected outcomes and estimating the cost of exerting cognitive control and effort. Different elements of model-free RL models of ACC could be affected by the inflexible cortical dynamics, making it challenging to update their values. An agent can also use a world model, a representation of how the states of the world change, to plan its actions, through model-based RL. OCD has been hypothesized to be driven by reduced certainty of how the brain's world model describes changes. Cingulotomy might improve such uncertainties about the world and one's actions, making it possible to trust the outcomes of these actions more and thus reduce the urge to collect more sensory information in the form of compulsions. Connecting the neural dynamics models with the functional formulations can provide new ways of understanding the role of ACC in OCD, with potential therapeutic insights.
Zuo S, Wang H, Zhao Q
… +6 more, Tang J, Wang M, Zhang Y, Sang M, Tian J, Wang P
Front Integr Neurosci
· 2022 · PMID 36686268
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BACKGROUND: The diagnosis of Parkinson's disease (PD) is complex and there are no biomarkers for early identification. Many studies have reported altered gut microbiota in patients with PD compared with healthy individua...BACKGROUND: The diagnosis of Parkinson's disease (PD) is complex and there are no biomarkers for early identification. Many studies have reported altered gut microbiota in patients with PD compared with healthy individuals. However, results from previous studies vary across countries. AIMS: The aim of this study was to identify gut microbiota biomarkers that could be used as a marker for the diagnosis of PD. METHODS: Firstly, the differential gut microbiota was obtained by meta-analysis, and then the results of meta-analysis were validated through metagenomic cohort. Finally, the ROC curve was drawn based on the metagenomic validation results. RESULTS: The meta-analysis showed a lower relative abundance of ( < 0.00001) and ( = 0.002), and a higher of ( < 0.00001), ( = 0.03), ( < 0.00001), and ( = 0.02) in patients with PD. Only was also at high levels in the validation cohort of the metagenome. Meanwhile, three species from the , including ( = 0.022), ( = 0.005), and ( = 0.024) were also high. The ROC curve showed that the three species (71.2%) from had good predictive efficiency for PD. CONCLUSION: Elevated may be associated with PD. Elevated three species from the , including , and may provide new potential biomarkers for the diagnosis of PD.
Front Integr Neurosci
· 2022 · PMID 36619239
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Sevoflurane is presently one of the most used inhaled anesthetics worldwide. However, the mechanisms through which sevoflurane acts and the areas of the brain associated with changes in consciousness during anesthesia re...Sevoflurane is presently one of the most used inhaled anesthetics worldwide. However, the mechanisms through which sevoflurane acts and the areas of the brain associated with changes in consciousness during anesthesia remain important and complex research questions. Sevoflurane is generally regarded as a volatile anesthetic that blindly targets neuronal (and sometimes astrocyte) GABAA receptors. This review focuses on the brain areas of sevoflurane action and their relation to changes in consciousness during anesthesia. We cover 20 years of history, from the bench to the bedside, and include perspectives on functional magnetic resonance, electroencephalogram, and pharmacological experiments. We review the interactions and neurotransmitters involved in brain circuits during sevoflurane anesthesia, improving the effectiveness and accuracy of sevoflurane's future application and shedding light on the mechanisms behind human consciousness.
Noble DJ, Dongmo R, Parvin S
… +2 more, Martin KK, Garraway SM
Front Integr Neurosci
· 2022 · PMID 36619238
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The mechanisms of neuropathic pain after spinal cord injury (SCI) are not fully understood. In addition to the plasticity that occurs within the injured spinal cord, peripheral processes, such as hyperactivity of primary...The mechanisms of neuropathic pain after spinal cord injury (SCI) are not fully understood. In addition to the plasticity that occurs within the injured spinal cord, peripheral processes, such as hyperactivity of primary nociceptors, are critical to the expression of pain after SCI. In adult rats, truncal stimulation within the tuning range of C-low threshold mechanoreceptors (C-LTMRs) contributes to pain hypersensitivity and elevates respiratory rates (RRs) after SCI. This suggests that C-LTMRs, which normally encode pleasant, affiliative touch, undergo plasticity to transmit pain sensation following injury. Because tyrosine hydroxylase (TH) expression is a specific marker of C-LTMRs, in the periphery, here we used TH-Cre adult mice to investigate more specifically the involvement of C-LTMRs in at-level pain after thoracic contusion SCI. Using a modified light-dark chamber conditioned place aversion (CPA) paradigm, we assessed chamber preferences and transitions between chambers at baseline, and in response to mechanical and optogenetic stimulation of C-LTMRs. In parallel, at baseline and select post-surgical timepoints, mice underwent non-contact RR recordings and von Frey assessment of mechanical hypersensitivity. The results showed that SCI mice avoided the chamber associated with C-LTMR stimulation, an effect that was more pronounced with optical stimulation. They also displayed elevated RRs at rest and during CPA training sessions. Importantly, these changes were restricted to chronic post-surgery timepoints, when hindpaw mechanical hypersensitivity was also evident. Together, these results suggest that C-LTMR afferent plasticity, coexisting with potentially facilitatory changes in breathing, drives at-level affective pain following SCI in adult mice.
Randolph AC, Henry A, Hewitt A
… +6 more, Mejia AP, Sethuraju R, DeJoseph M, Koenig M, Elison JT, Fair DA
Front Integr Neurosci
· 2022 · PMID 36591337
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Following the murder of George Floyd on May 25, 2020, Minneapolis represented the epicenter of protests that would reverberate internationally and re-instantiate a reckoning of the systemic and institutional racism that...Following the murder of George Floyd on May 25, 2020, Minneapolis represented the epicenter of protests that would reverberate internationally and re-instantiate a reckoning of the systemic and institutional racism that plagues American society. Also in the summer of 2020, and after several years of planning, the University of Minnesota (UMN) launched the Masonic Institute for the Developing Brain (MIDB), an interdisciplinary clinical and community research enterprise designed to create knowledge and engage all members of our community. In what follows, we describe the mission of the MIDB Community Engagement and Education (CEEd) Core and adjacent efforts within the UMN neuroscience and psychology community. Inherent to these efforts is the explicit attempt to de-center the dominant academic voice and affirm knowledge creation is augmented by diverse voices within and outside of traditional academic institutions. We describe several initiatives, including the Neuroscience Opportunities for Discovery and Equity (NODE) network, the NextGen Psych Scholars Program (NPSP), the Young Scientist Program, among others as exemplars of our approach. Developing and fortifying sustainable pathways for authentic community-academic partnerships are of central importance to enhance mutually beneficial scientific discovery. We posit that traditional academic approaches to community engagement to benefit the institution are severely constrained and perpetuate inherently exploitative power dynamics between academic institutions and communities.