Braz Oral Res [JOURNAL]
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200 papers
Microneedles enhance the efficacy of topical dental anesthesia in male subjects: a randomized controlled trial.
Santos SDC, Moreira NCF, Abdalla HB … +3 more , Augusto GGX, Costa YM, Franz-Montan M
Braz Oral Res · 2026 · PMID 42154829 · Full text
This study aimed to determine whether microneedles (MN) can enhance the efficacy of a commercially available topical anesthetic (EMLA®) when applied to the palatal mucosa. In a randomized, double-blind, crossover trial,...
This study aimed to determine whether microneedles (MN) can enhance the efficacy of a commercially available topical anesthetic (EMLA®) when applied to the palatal mucosa. In a randomized, double-blind, crossover trial, 30 male volunteers received bilateral applications of MN patches and flat patches (FL, without MN) on the palatal mucosa. EMLA® was subsequently applied for either 2 or 5 min in separate sessions. Immediately thereafter, infiltrative anesthesia was administered, and pain intensity associated with needle insertion and local anesthetic injection was measured using a 0-100 Visual Analogue Scale. No differences in pain intensity were observed during needle insertion or local anesthetic injection when MN and FL patches were compared, irrespective of the duration of EMLA® application. However, a significantly higher proportion of participants reported pain-free infiltrative anesthesia when EMLA® was applied for 2 min following MN pretreatment (40%) compared with FL pretreatment (10%) (p = 0.008). MN application was not associated with adverse effects. Pretreatment with MN enhances the clinical efficacy of intraoral topical anesthesia in males. These findings open new avenues for exploration of advanced transbuccal drug delivery technologies focused on fast-release systems that may improve clinical outcomes in topical dental anesthesia.
Sense of coherence as a protective factor in sleep and awake bruxism effects on adolescents quality of life.
Knorst JK, Machado E, Borstmann EDS … +1 more , Ardenghi TM
Braz Oral Res · 2026 · PMID 42154828 · Full text
This study aimed to assess whether the sense of coherence (SOC) moderates the association between self-reported sleep bruxism (SB) and self-reported awake bruxism (AB) on oral health-related quality of life (OHRQoL). A c...
This study aimed to assess whether the sense of coherence (SOC) moderates the association between self-reported sleep bruxism (SB) and self-reported awake bruxism (AB) on oral health-related quality of life (OHRQoL). A cross-sectional analysis was conducted with a random sample of 406 adolescents aged 11 to 17 years from Southern Brazil. OHRQoL was measured using the Child Perception Questionnaire (CPQ11-14). Both SB and AB were assessed by self-report (weekly frequency). SOC was measured using the 13-item Sense of Coherence Scale (SOC-13). Demographic, socioeconomic, and clinical variables were included as potential confounders. Poisson regression models were used to test interaction effects. Adolescents with bruxism behaviour-either SB or AB-presented significantly higher CPQ11-14 scores, indicating poorer OHRQoL. SOC moderated this association: adolescents with SB and low SOC reported worse OHRQoL than those with high SOC. Similar results were observed for AB. In addition, the moderating effect was stronger for AB, with a greater difference in predicted CPQ11-14 scores across SOC levels. These findings suggest that SOC may buffer the psychosocial and functional effects of bruxism. Strengthening SOC could be a promising avenue for interventions aimed at minimizing the quality-of-life burden of bruxism in adolescents.
Effect of strict oral hygiene on self-rated halitosis and quality of life in patients with periodontitis: a secondary randomized controlled trial analysis.
Costa BFBD, Alves VF, Cassiano LS … +4 more , Nascimento GG, Paiva VMS, Silva LVLE, Aquino SG
Braz Oral Res · 2026 · PMID 42154827 · Full text
This single-blind, randomized clinical trial evaluated the impact of a strict oral hygiene (OH) phase on self-reported halitosis and quality of life (QoL) in patients with periodontitis. This study reports a secondary an...
This single-blind, randomized clinical trial evaluated the impact of a strict oral hygiene (OH) phase on self-reported halitosis and quality of life (QoL) in patients with periodontitis. This study reports a secondary analysis of a single-blind randomized controlled trial (parallel, 1:1), registered at RBR-5jmx32v. The study included 24 individuals diagnosed with periodontitis who were randomly assigned to the intervention group (IG; n = 12) and the no-intervention group (NIG; n = 12). After receiving personalized OH instructions, the IG participants followed a rigorous OH phase for 45 days, whereas the NIG participants received no guidance during this period. The halitosis-associated QoL test (HALT) was administered at baseline and after 45 days. Data were analyzed using t-tests, chi-square tests, and multilevel linear regression, with significance set at p < 0.05. The average age of the study participants was 47.2 years, with a balanced sex distribution and no differences in income or education. Self-reported halitosis decreased from 100% to 50% in the IG after 45 days, whereas it remained at 91.6% in the NIG (p = 0.034). The IG also showed a mean HALT score reduction of 11.9 points (-11.88; 95% CI: -19.40 to -4.36), with significant improvements in social impact and self-esteem (p < 0.05). Clinically, BOP (p < 0.001) and VPI (p = 0.03) improved significantly in the IG, with no significant changes in NIG. This exploratory trial demonstrates that implementing a strict OH phase in patients with periodontitis may help reduce self-reported halitosis, improve HALT scores, and improve clinical outcomes, supporting its role as an adjunctive strategy in periodontal care.
NiTi instruments in endodontics: contemporary concepts, principles, and practical guidance.
Silva EJNLD, Martins JNR, Versiani MA
Braz Oral Res · 2026 · PMID 42138960 · Full text
This review synthesizes current laboratory and clinical evidence on nickel-titanium (NiTi) endodontic instruments and translates it into guidance for clinical practice, addressing inconsistencies in the translation of re...
This review synthesizes current laboratory and clinical evidence on nickel-titanium (NiTi) endodontic instruments and translates it into guidance for clinical practice, addressing inconsistencies in the translation of research findings and a lack of standardization. Evidence on the evolution, metallurgy, heat treatments (e.g., M-Wire, Gold, and Blue), geometric design, mechanical properties, and clinical performance of contemporary NiTi systems were synthesized, with emphasis on shaping outcomes, including canal transportation, volumetric changes, unprepared canal walls, and remaining dentin thickness. Modern NiTi instruments, particularly those with advanced heat treatments, provide superior flexibility and cyclic fatigue resistance compared with conventional alloys, enabling safer and more predictable canal preparation. Continuous rotary systems often achieve better canal centering and less transportation than reciprocating systems; however, both leave a substantial portion of canal walls untouched, highlighting the essential role of chemical debridement. Long-term clinical success depends primarily on biological factors and careful technique rather than on the specific instrument system. Therefore, NiTi instruments represent the standard of care, offering anatomically respectful canal shaping. Clinicians should integrate knowledge of alloy properties, design features, and failure mechanisms with conservative, load-managing techniques to maximize safety and efficiency.
Multicenter study of oral and maxillofacial thrombi: analysis of 187 cases.
Silva WRD, Faria CAB, Cavalcanti JFDS … +25 more , Morais HGF, Farias DM, Cepeda IVB, Nobre DAB, Drumond VZ, Nunes BMMB, Barros CCDS, França GM, Mendonça EF, Arantes DAC, Nascimento GJFD, Silva LPD, Carvalho CHP, Tenório JDR, Arruda JAA, Andrade BAB, Vasconcelos ACU, Gomes APN, Abreu LG, Carvalho EJA, Perez DEDC, Mesquita RA, Galvão HC, Freitas RA, Sobral APV
Braz Oral Res · 2026 · PMID 41919914 · Full text
This study aimed to investigate the clinicopathological characteristics of thrombi in the oral and maxillofacial region. A cross-sectional study was conducted in nine reference centers for oral and maxillofacial patholog...
This study aimed to investigate the clinicopathological characteristics of thrombi in the oral and maxillofacial region. A cross-sectional study was conducted in nine reference centers for oral and maxillofacial pathology diagnosis in Brazil, from which biopsy records were obtained. The data were analyzed descriptively. A total of 93,036 biopsies from the oral and maxillofacial region were evaluated, 187 (0.2%) of which were diagnosed as thrombi. The highest occurrence was in females, with a mean age of 52.4 ± 17.7 years. The lip was the most frequently affected anatomical location. A clinical diagnostic hypothesis of thrombus was considered in 4.2% of cases. Oral thrombi were uncommon lesions in the studied population, with a higher occurrence among females in the seventh decade of life. This study provides a clinicopathological profile of oral and maxillofacial thrombi and offers information that may assist clinicians in establishing a diagnosis.
The role of social cohesion in gingival bleeding levels among adolescents: a cross-sectional study.
Moletta RP, Baroni V, Borstmann EDS … +3 more , Knorst JK, Sfreddo CS, Ardenghi TM
Braz Oral Res · 2026 · PMID 41919913 · Full text
This study aimed to evaluate the relationship between social cohesion and gingival bleeding levels in adolescents from Santa Maria, southern Brazil. This cross-sectional study was nested within a cohort study initiated i...
This study aimed to evaluate the relationship between social cohesion and gingival bleeding levels in adolescents from Santa Maria, southern Brazil. This cross-sectional study was nested within a cohort study initiated in 2010 with a representative sample of preschool children aged 1 to 5 years in the city. Participants were re-evaluated at ages 11 and 15 years, resulting in a 10-year follow-up period. The current study used data from this follow-up. Social cohesion was assessed at an individual level through questions about perceptions of neighborhood relationships and the frequency of participation in neighborhood gatherings. Gingival bleeding was evaluated clinically using the Community Periodontal Index (CPI). Sociodemographic and clinical variables were considered as potential confounders. Multilevel adjusted Poisson regression was used to assess associations, and results were expressed as rate ratios (RR) with 95% confidence intervals (95%CI). A total of 429 adolescents were included. In the adjusted model, poor perception of neighborhood relationships was associated with higher gingival bleeding levels (RR = 1.08; 95%CI: 1.03-1.13). Adolescents who did not attend local gatherings had even higher bleeding levels (RR = 1.45; 95%CI: 1.34-1.47). Additionally, non-white adolescents, those with lower income, irregular dental visits, and higher plaque levels also showed greater bleeding. Girls had lower gingival bleeding levels compared to boys. Lower social cohesion, reflected by negative neighborhood perceptions and lack of community participation, was associated with higher gingival bleeding in adolescents. Public health strategies aiming to improve adolescent oral health should focus on strengthening neighborhood relationships and promoting active community engagement as key social determinants.
Characterization of bovine-teeth nanoparticles and its effect on BMP-2 expression in periodontitis rat model.
Sari DS, Fiolita SV, Martin M … +7 more , Fadiyah SN, Herniyati, Latief FDE, Pujiastuti P, Arina YMD, Maduratna E, Ramli H
Braz Oral Res · 2026 · PMID 41919912 · Full text
Bovine teeth-derived nanoparticles show strong potential in regenerating alveolar bone tissue damaged by periodontitis. They possess osteoinductive and osteoconductive properties that stimulate cell differentiation, prol...
Bovine teeth-derived nanoparticles show strong potential in regenerating alveolar bone tissue damaged by periodontitis. They possess osteoinductive and osteoconductive properties that stimulate cell differentiation, proliferation, and extracellular matrix formation. This study characterized nanoparticles from bovine teeth and evaluated their potential for alveolar bone regeneration via particle size analysis, transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray fluorescence (XRF), Brunauer-Emmett-Teller (BET) analysis, micro-computed tomography, and Fourier-transform infrared spectroscopy (FTIR). Twenty Wistar rats were divided into four groups: one control and three treatment groups, which were observed on days 7, 14, and 28. The rats were injected with lipopolysaccharides from Porphyromonas gingivalis to create a model of periodontitis model. Bovine teeth nanoparticles were applied to the periodontal pockets and covered with a periodontal dressing. The particle sizes ranged from 3.67 to 36.75 nm. TEM images revealed that the particles were spherical, while XRD analysis showed that the components consisted of 63% hydroxyapatite and 37% whitlockite. XRF analysis showed that the mineral content was highest in calcium (81.96%) and phosphorus (15.90%). BET analysis indicated that the characteristics of the nanoparticle material were similar to those of commercial bovine bone material. FTIR analysis revealed the presence of hydroxyapatite groups, including -OH, H2O, and P-4. BMP-2 expression levels were notably higher in the repaired bone on day 28 than on days 7 and 14. In conclusion, bovine teeth-derived nanoparticles demonstrate significant potential as biomaterials for alveolar bone regeneration in periodontitis therapy.
Evaluation of bioactive restorative materials on cell viability using direct and extract methods.
Kilinc ZE, Bengi VU, Savas S … +1 more , Kucukyilmaz E
Braz Oral Res · 2026 · PMID 41919911 · Full text
The biological response of gingival fibroblasts to restorative materials is a key factor in determining the clinical success. This study aimed to evaluate the effects of four restorative materials on the viability of gin...
The biological response of gingival fibroblasts to restorative materials is a key factor in determining the clinical success. This study aimed to evaluate the effects of four restorative materials on the viability of gingival fibroblast cell cultures using a real-time cell analysis system with direct extract methods. Four different restorative materials with bioactive properties were used in this study: Glasiosite (VOCO GmbH, Cuxhaven, Germany), BEAUTIFIL-Bulk Restorative (Shofu Inc., Kyoto, Japan), EQUIA Forte™ HT Fil (GC Corporation, Tokyo, Japan), and Activa BioACTIVE Restorative® (Pulpdent Corporation, Watertown, USA). Disc-shaped specimens were prepared for each material group (n = 18 and n = 9 for each test method). The effects of the materials on gingival fibroblast viability were determined using both direct and extract methods with a real-time cell analysis system (xCELLigence) at two different time periods (24 h and 48 h). A significance level of α = 0.05 was adopted for all statistical analyses. The control group exhibited the highest cell viability, and the differences between the groups were statistically significant at both 24 h and 48 h (p < 0.05). At both 24 h and 48 h, Glasiosite showed the highest cell viability among the tested materials, whereas the BEAUTIFIL-Bulk Restorative exhibited the lowest cell viability (p < 0.05). Cell viability was significantly higher with the extract method than with the direct contact method across all materials, except for the control (p < 0.05). This study revealed that the cell viability varied significantly depending on the material type, exposure time, and test method. Glasiosite showed the highest biocompatibility, while the BEAUTIFIL-Bulk Restorative exhibited the lowest value.
Brightness and contrast adjustments influence proximal caries detection on handheld X-ray radiographs.
Ruiz DC, Morais MNDS, Gaêta-Araujo H … +3 more , Oliveira ML, Freitas DQ, Haiter-Neto F
Braz Oral Res · 2026 · PMID 41919910 · Full text
This study evaluated the influence of brightness and contrast adjustments on the diagnosis of proximal caries lesions in radiographs acquired with a handheld X-ray device. A complementary metal oxide semiconductor sensor...
This study evaluated the influence of brightness and contrast adjustments on the diagnosis of proximal caries lesions in radiographs acquired with a handheld X-ray device. A complementary metal oxide semiconductor sensor (SnapShot, Instrumentarium Imaging, Milwaukee, WI, USA) and a handheld Eagle X-ray device (Alliage, São Paulo, Brazil) were used to acquire radiographs of 20 mandibular molars and 20 mandibular premolars randomly arranged in 20 phantoms. The device settings were 60 kVp, 2.5 mA, and 0.45 seconds of exposure. Brightness and contrast of the resulting radiographs were modified in four combinations: a) -30% brightness and +30% contrast; b) -15% brightness and +15% contrast; c) +15% brightness and -15% contrast; and d) +30% brightness and -30% contrast. After randomization, the original radiographs and the four modified versions were individually assessed by five oral and maxillofacial radiologists to detect proximal caries lesions. The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity were calculated from the examiners' responses and compared with one-way analysis of variance (p<0.05). Intra- and inter-examiner agreement for radiographic diagnosis was assessed using the weighted kappa index. Sensitivity values for detecting proximal caries lesions on radiographs with increased brightness and decreased contrast (+ 30% brightness and -30% contrast) were significantly lower compared with the other combinations (p < 0.05), whereas AUC and specificity values were not influenced by the adjustments tested (p > 0.05). Therefore, increasing brightness and decreasing contrast on radiographs acquired with a handheld X-ray device is not recommended, since it may impair diagnostic accuracy for proximal caries lesions.
Dental anomalies and medical history: prematurity as a risk factor for agenesis.
Dib ACC, Silva RABD, Silva LABD … +5 more , Silva FWGPE, Nelson-Filho P, Chaves GC, Alves GR, Lucisano MP
Braz Oral Res · 2026 · PMID 41880449 · Publisher ↗
The aims of this retrospective radiographic study were to assess the occurrence of dental anomalies in children and patients with disabilities and to investigate the association of these anomalies with pre-, peri-, and p...
The aims of this retrospective radiographic study were to assess the occurrence of dental anomalies in children and patients with disabilities and to investigate the association of these anomalies with pre-, peri-, and post-natal medical history. A total of 289 panoramic radiographs of children (0-14 years) and patients with disabilities (including all age groups) were used to identify developmental dental anomalies, and information was collected from medical records for statistical analysis. Data were expressed as relative frequency (percentage). The chi-square test, Fisher's exact test, relative risk calculation, and the Mann-Whitney test were used for statistical comparisons with a significance level of 5%. Occurrence of dental alterations was 50.34% in children and 37.50% in patients with disabilities. Agenesis was the most common alteration (24.14% in children and 30.55% in patients with disabilities). The study found a relative risk of 2.6 for agenesis in children with a history of prematurity (p = 0.02). The variable "performing medical treatment" was a risk factor for the presence of dental alterations in children. The age and the medical conditions of the patients with disabilities varied greatly, with neurological diseases being the most prevalent disability. However, the health history of mothers during pregnancy was not associated with dental alterations in patients with disabilities (p > 0.05). Developmental dental anomalies were frequently observed in both groups, with agenesis being the most common condition. Prematurity was identified as a predictive factor for agenesis.
Lower dental pulp oxygen saturation in children with molar incisor hypomineralization: a cross-sectional study.
Cavalcante JS, Estrela C, Carvalho FK … +4 more , Paula-Silva FWG, Sousa-Neto MD, Molena KF, Queiroz AM
Braz Oral Res · 2026 · PMID 41880448 · Publisher ↗
This study evaluated the oxygen saturation of pulp tissue (SaO2) in first primary molars (FPM) with and without molar incisor hypomineralization (MIH) and explored the correlations between MIH severity and pulp SaO2 leve...
This study evaluated the oxygen saturation of pulp tissue (SaO2) in first primary molars (FPM) with and without molar incisor hypomineralization (MIH) and explored the correlations between MIH severity and pulp SaO2 levels. The cross-sectional design involved 29 children (16 girls and 13 boys, aged 7-11 years), yielding 116 FPM. The FPM were categorized into groups based on the presence or absence of MIH: Group 1 (G1) included teeth without MIH (n = 48); Group 2 (G2), mild MIH cases (n = 30); and Group 3 (G3), severe MIH cases (n = 38). Pulse oximetry was used to assess SaO2, with measurements conducted twice for each tooth, each lasting 30 seconds. Significant variations in the SaO2 levels were observed relative to the severity of MIH. The median SaO2 in G1 was 94% (IQR 90-98%), while MIH cases showed lower levels: 79% (IQR 71.5-83.5%) for mild MIH (G2) and 68% (IQR 55-75%) for severe MIH (G3) (p < 0.001). The FPM affected by MIH (G2 and G3) demonstrated lower SaO2 levels than those in G1, with severe cases exhibiting even lower levels than mild cases. This study provides important insights into the relationship between MIH severity and pulp SaO2 and suggests significant implications for clinical management strategies.
Cytocompatibility and bioactive potential of Pentaclethra macroloba extract and Ca(OH)2 as intracanal medication.
Gioster-Ramos ML, Maquera-Huacho PM, Leguizamon NDP … +4 more , Spolidorio DP, Messias R, Kuga MC, Vaz LG
Braz Oral Res · 2026 · PMID 41880447 · Publisher ↗
Alternative therapies using plant-derived extracts are currently being studied due to their beneficial properties. This study investigated the Amazonian extract of Pentaclethra macroloba, pure and in combination with cal...
Alternative therapies using plant-derived extracts are currently being studied due to their beneficial properties. This study investigated the Amazonian extract of Pentaclethra macroloba, pure and in combination with calcium hydroxide, regarding its biological properties in endodontics. Osteoblast Saos-2 and Fibroblast L929 cell lines were used for evaluation of cell viability/metabolism by MTT (48h), cell proliferation with Alamar blue (1, 3, 5 and 7 days), mineralization with Alizarin Red (7 days) and alkaline phosphatase activity (7 days). In Saos-2, lower concentrations of the medications were less cytotoxic in the MTT assay. There was cell proliferation on days 3 and 5. Mineralization nodules were observed in the 3 groups. In L929 cells, the lowest concentrations were not cytotoxic in the MTT assay, and there was cell proliferation on days 3, 5, and 7. Pentaclethra macroloba extract was not cytotoxic, it induced cell proliferation, and was able to form mineralization nodules, essential characteristics for endodontic medications.
Prognostic value of preoperative coagulation scoring system in patients with oral squamous cell carcinoma.
Wang X, Ji X
Braz Oral Res · 2026 · PMID 41880446 · Publisher ↗
Abnormal coagulation function is closely associated with the prognosis of patients with malignant tumors. In this study, we aimed to explore the prognostic value of preoperative coagulation scoring system in patients wit...
Abnormal coagulation function is closely associated with the prognosis of patients with malignant tumors. In this study, we aimed to explore the prognostic value of preoperative coagulation scoring system in patients with oral squamous cell carcinoma (OSCC). A total of 267 patients with OSCC who were treated at the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University between January 2016 and December 2019 were included. Survival prediction values for fibrinogen level and international normalized ratio (INR) were identified according to receiver operating characteristic (ROC) cut-off analysis. Patients were divided into three groups based on the F-INR score combined with fibrinogen and INR: score 2 group (both high fibrinogen and high INR), score 1 group (either elevated fibrinogen or INR), and score 0 group (neither abnormality). The association between F-INR score and clinicopathological parameters was evaluated. The clinical risk factors were evaluated using univariate and multivariate Cox regression analyses. Kaplan-Meier analysis was used to estimate the survival of patients with OSCC. The predictive value of preoperative F-INR in OSCC was better than that of fibrinogen and INR alone (area under the curve, (AUC): 0.766 vs. 0.704 vs. 0.611). Multivariate Cox regression analysis showed that F-INR may be an independent predictor of cancer-specific survival (CSS) in OSCC (F-INR 1, hazard ratio [HR] = 8.210, 95%CI: 1.156-58.282, p = 0.035; F-INR 2, HR = 2.475, 95%CI: 1.284-4.772, p = 0.007). Kaplan-Meier analysis indicated that patients with high fibrinogen levels or F-INR had a poor prognosis (p < 0.05). Preoperative F-INR may be an independent prognostic factor in patients with OSCC.
Relationship between sense of coherence and dental attendance patterns among Brazilian adolescents.
Rios LE, Freire MDCM
Braz Oral Res · 2026 · PMID 41880445 · Publisher ↗
This study aimed to investigate if sense of coherence (SOC) is associated with dental attendance (DA) patterns among Brazilian adolescent students. A cross-sectional study was conducted in the midwestern region of Brazil...
This study aimed to investigate if sense of coherence (SOC) is associated with dental attendance (DA) patterns among Brazilian adolescent students. A cross-sectional study was conducted in the midwestern region of Brazil. A total of 2,905 adolescents aged 13 to 19 years from 14 public schools in 13 towns/cities in the state of Goiás were included in the study. Data on oral health-related behaviors and psychosocial factors were collected using self-administered questionnaires completed by students during regular school hours. The dependent variables were DA in the past year (yes/no) and the reason for DA (toothache/preventive check-up). SOC was assessed using the Antonovsky's Orientation to Life questionnaire (SOC-13). Adjusted odds ratios (OR) and 95% confidence intervals were estimated using binary logistic regression. Results showed that 56.2% of the students had visited a dentist within the past year, most commonly for a preventive check-up (38.7%). SOC scores ranged from 13 to 91 (mean = 49.3; SD = 12.1). In the regression model adjusted for adolescents' sociodemographic characteristics (age, sex, skin color or race, and maternal education), higher prevalence rates of DA in the past year (OR = 1.02; p < 0.001) and DA motivated by preventive check-ups (OR = 1.02; p < 0.001) were found among those with higher SOC scores. In conclusion, a significant association was found between higher SOC levels and healthier DA patterns among adolescents, regardless of socioeconomic characteristics.
Evaluation of locator versus TITACH attachments for mandibular 2-implant overdentures: a one-year randomized controlled clinical trial.
Abozaed HW, Eladrosi MA, Elsyad MA
Braz Oral Res · 2026 · PMID 41810622 · Full text
Implant overdenture attachments serve as the crucial link between dental implants and removable dentures, significantly enhancing the stability, retention, and function of the prosthesis. This study was designed to asses...
Implant overdenture attachments serve as the crucial link between dental implants and removable dentures, significantly enhancing the stability, retention, and function of the prosthesis. This study was designed to assess the effectiveness of locator and TITACH attachments in retaining mandibular two-implant overdentures, maximum bite force, and marginal bone loss. The study involved 36 edentulous patients, each receiving new complete dentures (CDs) designed with the bilateral balanced occlusal concept. Two implants were positioned in the mandibular canine regions. Participants were randomly assigned to two equal groups: Group I (LOA) with overdentures using locator attachments, and Group II (TIA) with overdentures using TITACH attachments. Retention and maximum bite forces were measured using a digital force meter and bite force transducers at baseline (T0), and at 6 months (T6), and 12 months (T12) post-insertion. After insertion, marginal bone loss (MBL) was evaluated using digital periapical radiographs at T6 and T12. Retention significantly decreased over time across all groups (p = 0.024 for CD, p < 0.001 for LOA and TIA). Maximum bite forces significantly declined for LOA (p = 0.007) and TIA (p = 0.003) at all measurement intervals. TIA demonstrated the highest retention and bite forces, followed by LOA, while CDs exhibited the lowest retention and bite forces. TIA was associated with significantly greater MBL than LOA (p = 0.002 and p < 0.001 for TIA). TITACH attachments showed superior retention and maximum bite force compared to locator attachments. Both attachment types offered improved retention and maximum bite forces relative to complete dentures. Additionally, locator attachments were associated with less peri-implant bone loss than TITACH attachments.
Malocclusions in primary teeth and quality of life: perception of preschoolers and their parents/guardians.
Coqueiro LJDS, Silvestre GVM, Bendo CB … +6 more , Dantas Neta NB, Matias FADS, Lima CCB, Moura MS, Moura LFAD, Lima MDM
Braz Oral Res · 2026 · PMID 41810621 · Full text
Malocclusions in primary teeth affect chewing, speech, and aesthetics. Few studies have assessed their impact on preschoolers' self-reported quality of life. This study aims to determine the association between malocclus...
Malocclusions in primary teeth affect chewing, speech, and aesthetics. Few studies have assessed their impact on preschoolers' self-reported quality of life. This study aims to determine the association between malocclusions in primary teeth and preschoolers' quality of life based on reports from children and their parents/guardians. A cross-sectional study was conducted Using a stratified, simple, randomly probabilistic sample. Based on sample size estimation, the study included 566 five-year-old preschoolers and their parents/guardians from Teresina, Brazil. Pediatric Quality of Life InventoryTM questionnaire and sociodemographic forms were applied, and clinical examination was performed. The dmft index, modified developmental defects of enamel, and Foster & Hamilton criteria were used for diagnosis. Descriptive analysis and Poisson regression were performed (p < 0.05; 95% CI). Prevalence of malocclusion was 51.2%. Parents/guardians reported edge-to-edge overjet negatively affected physical capacity (RR = 1.11; 95%CI: 1.02-1.20) and social aspects (RR = 1.11; 95%CI: 1.03-1.19). According to children's self-reports, posterior crossbite affected the total score (RR = 1.43; 95%CI: 1.03-1.97) and oral health (RR = 1.08; 95%CI: 1 .04-1.13), whereas reduced overbite was linked to negative effects on the emotional aspect (RR = 1.10; 95%CI: 1.01-1.18) and oral health (RR = 1.08; 95%CI: 1.01-1.16). Malocclusions have a negative impact on the quality of life of preschoolers, as reported by parents and children.
Prevalence of dental caries lesions in Costa Rican children under 81 months living in poverty.
Gudiño-Fernandez S, Molina-Chaves K, Gomez-Fernandez A
Braz Oral Res · 2026 · PMID 41810620 · Full text
Dental caries remains a significant public health issue, particularly among children from low-income areas, where limited access to preventive and restorative care increases the disease burden. In Costa Rica, recent data...
Dental caries remains a significant public health issue, particularly among children from low-income areas, where limited access to preventive and restorative care increases the disease burden. In Costa Rica, recent data on the prevalence of caries in children under seven years of age are lacking. This nationwide study aimed to determine the prevalence and severity of dental caries lesions in Costa Rican children aged 12-81 months living in poverty and enrolled in the Centers for Education and Nutrition and Comprehensive Child Nutrition and Care Centers (CEN-CINAI), which are national childcare and nutrition programs. A cross-sectional descriptive study was conducted with 800 children from urban and rural areas. The probability-proportional-to-size (PPS) method was used to select 40 centers, with systematic random sampling of 25 children per center. Clinical examinations were performed by eight calibrated examiners following the International Caries Detection and Assessment System (ICDAS) criteria to assess oral health conditions. The inter- and intraexaminer kappa values ranged from 0.80-0.93. The overall prevalence of caries lesions was 84.81% (ICDAS codes 1-6), with 47.19% of the participants presenting moderate-to-severe carious lesions (ICDAS codes 3-6). The highest prevalence was observed in the 37-48-month age group (91.45%). Differences in the prevalence of caries by sex were more evident in younger age groups and minimal in the older age groups. Only 28.75% of the children with caries had received restorative treatment. The 37-48-month age group presented the highest prevalence of caries, with most lesions being moderate to severe and treatment coverage remaining low.
Effect of titanium dioxide nanotubes in Ca(OH)2-based intracanal medicaments on odontoblast-like cells.
Lopes MABS, Costa BC, Nociti Junior FH … +2 more , Lisboa Filho PN, Kantovitz KR
Braz Oral Res · 2026 · PMID 41810619 · Full text
This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondr...
This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic activity of mouse dental papilla cells (MDPC-23). Five experimental groups were evaluated (n=3 per group): Cells (control), Calen, Calen + 3wt% nTiO2, Ultracal, and Ultracal + 3wt% nTiO2. Cell proliferation, viability, and mitochondrial metabolic activity were assessed using the Trypan Blue exclusion and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays at 24, 48, and 72 h. Data analysis included the Shapiro-Wilk and Levene tests and generalized linear models (p<0.05). At 24 and 48 h, both Ultracal and Ultracal + 3wt% nTiO2 showed significantly higher proliferation than the Calen groups (p<0.0001). The control group (Cells) exhibited the highest viable cell counts (p<0.0005). At 72 h, Calen + 3wt% nTiO2 showed the lowest proliferation compared with both the Cells and the Ultracal groups (p<0.0001). No significant differences were observed in non-viable cell counts or viable/non-viable ratios over time (p>0.05). Furthermore, Calen and Calen + 3 wt% nTiO2 at 24 and 48 h, as well as Calen + 3wt% nTiO2 at 72 h, demonstrated the lowest metabolic activity (p<0.0001), with no significant effect of nTiO2 (p>0.05). No significant intra-group differences over time were observed for the Cells or Ultracal groups (p=0.0608 and p=0.1417, respectively). Overall, the incorporation of nTiO2 did not adversely affect the biological parameters of Ca(OH)2-based ICMs assessed in this study. Further investigations are warranted to elucidate potential clinical implications.
Dental tissue fractures and their relationship with deciduous molar hypomineralization, molar incisor hypomineralization, and psychosomatic factors: a cross-sectional study.
Silva JV, Barbosa LLO, Porto ICCM … +1 more , Santos Junior VED
Braz Oral Res · 2026 · PMID 41810618 · Full text
This study aimed to investigate the relationship between post-eruptive dental fractures, hypomineralization, and psychosomatic factors such as anxiety, headache, awake bruxism, and temporomandibular disorder (TMD) in chi...
This study aimed to investigate the relationship between post-eruptive dental fractures, hypomineralization, and psychosomatic factors such as anxiety, headache, awake bruxism, and temporomandibular disorder (TMD) in children aged 7 to 12 years. A cross-sectional study involving 274 children was conducted using clinical examinations based on the European Academy of Pediatric Dentistry (EAPD) criteria for the diagnosis of hypomineralization and post-eruptive breakdown. Structured and validated questionnaires were administered through interviews to assess psychosomatic factors such as anxiety, headache, awake bruxism, and TMD. Statistical analysis included descriptive and inferential analyses using Fisher's exact test and the chi-square test. The margin of error was 5%, with a 95% confidence interval. Tissue breakdown was observed in 6.2% of children, with a higher prevalence in posterior teeth. A significant association was found between tissue breakdown and hypomineralization in deciduous (p=0.002) and permanent teeth (p < 0.001), especially when hypomineralization presented as yellow-brown (p < 0.001). Anxiety, awake bruxism, and TMD were not significantly associated with such fractures, but they were significantly associated with headache (p = 0.023). Additionally, dental caries (p = 0.003) and occlusal wear (p < 0.001) were associated with tissue breakdown. Post-eruptive breakages were found to be associated with dental enamel hypomineralization in deciduous and permanent teeth. Furthermore, dental caries and occlusal wear were identified as key contributing factors for these fractures. In conclusion, post-eruptive fractures were associated with enamel hypomineralization in both deciduous and permanent teeth, as well as with dental caries and occlusal wear. Among psychosomatic factors, only headache showed a significant association.
Impact of root canal treatment on oral health-related quality of life: a prospective cohort study.
Guimarães LS, Silva EABD, Hespanhol FG … +3 more , Tavares MLCD, Antunes LAA, Antunes LS
Braz Oral Res · 2025 · PMID 41379131 · Full text
The objective of this study was to assess the impact of root canal treatment (RCT) in single-rooted teeth with asymptomatic apical periodontitis on oral health-related quality of life (OHRQoL). As a secondary objective,...
The objective of this study was to assess the impact of root canal treatment (RCT) in single-rooted teeth with asymptomatic apical periodontitis on oral health-related quality of life (OHRQoL). As a secondary objective, the impact of factors such as age, gender, ethnicity, tooth groups, arch position, crown destruction, postoperative pain, edema, and use of analgesics after procedure were also noted. A prospective cohort study was designed and enrolled in a sample of 105 patients who needed root canal treatment in single-rooted maxillary or mandibular teeth with asymptomatic apical periodontitis, without preoperative symptoms. RCT was performed in one session. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) at baseline and after seven and 30 days. Predictor variables were also collected: age, gender, ethnicity, tooth groups, arch position, destruction of the crown, postoperative pain, edema, and the use of analgesics. Data were tabulated and analyzed in SPSS software, with alpha value set at 0.05. All domains of the OHIP-14 questionnaire revealed a statistically significant difference between the times evaluated (p < 0.001), showing the positive impact of the RCT on OHRQoL, with moderate and large effects. There was a significant difference in the total score for gender (p = 0.001), ethnicity (p = 0.010), and crown destruction (p = 0.002). RCT improved OHRQoL scores in all domains assessed by OHIP-14, with moderate and large effects. Factors such as female gender, mixed race and afrodescendant participants, and extensive crown destruction negatively influenced the OHRQoL of patients pre-RCT.
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