Braz Oral Res [JOURNAL]
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200 papers
Impact of clinical stage and location of dental caries lesions on oral health-related quality of life.
Díaz S, Abanto J, Boneckër M … +3 more , Lara JS, Paiva SM, Olegário IC
Braz Oral Res · 2025 · PMID 41379130 · Full text
Assess the association between dental caries clinical stage, lesion location, and oral health-related quality of life (OHRQoL) in preschool children. A cross-sectional study was conducted with a representative sample of...
Assess the association between dental caries clinical stage, lesion location, and oral health-related quality of life (OHRQoL) in preschool children. A cross-sectional study was conducted with a representative sample of 643 caregiver-child dyads aged 0-5 years. Children underwent oral examinations using the International Caries Detection and Assessment System (ICDAS) and the International Caries Classification and Management System (ICCMS™) criteria to classify caries stage and lesion location. Traumatic dental injuries (TDI) were assessed using Andreasen's classification. Caregivers completed the Early Childhood Oral Health Impact Scale (ECOHIS). Weighted Kappa coefficients assessed intra- and inter-examiner reliability. Negative binomial regression models, adjusted for sociodemographic variables and clinical factors, estimated the association between caries stage/location and ECOHIS scores. The prevalence of dental caries (all stages) was 72.6%, with 27.3% of children caries-free. Overall, 48.2% of caregivers reported at least one oral health impact in their child's life (ECOHIS ≥ 1). Children with extensive lesions (stage C) had significantly worse total and domain ECOHIS scores than caries-free children (p < 0.001), regardless of lesion location. Moderate lesions (stage B) affected OHRQoL only when present in both anterior and posterior teeth (RR = 1.54; p = 0.045). Older age, public school attendance, and household crowding were also associated with poorer OHRQoL. The presence of TDI was independently associated with poorer OHRQoL (RR = 1.63; p < 0.001). These findings highlight the need for targeted, patient-centred interventions to address caries burden effectively.
In vitro disinfection, pH and solubility of bioceramic intracanal medication with calcium hydroxide.
Pontes LB, Lopes CS, Chávez-Andrade GM … +4 more , Pradelli JA, Silva GFD, Tanomaru-Filho M, Guerreiro-Tanomaru JM
Braz Oral Res · 2025 · PMID 41259579 · Full text
To evaluate the pH, solubility and intratubular disinfection of the bioceramic intracanal drug Bio-C® Temp (BCT), calcium hydroxide-based paste Calen® (CAL) and their associations in different proportions: BCT 75% + CAL...
To evaluate the pH, solubility and intratubular disinfection of the bioceramic intracanal drug Bio-C® Temp (BCT), calcium hydroxide-based paste Calen® (CAL) and their associations in different proportions: BCT 75% + CAL 25%; BCT 50% + CAL 50%; BCT 25% + CAL 75%. Polyethylene tubes containing the medication, were used. The pH was evaluated after 1, 3, 7, 14 and 21 days and solubility after 14 days. Bovine dentin tubes were contaminated with Enterococcus faecalis to assess intratubular disinfection by using confocal laser scanning microscopy and use of Live/Dead BacLight Bacterial stain. Data were submitted to statistical tests of normality, then ANOVA and Tukey (α = 0.05). BCT showed a lower pH after 3 and 14 days (p < 0.05). CAL had the highest pH at all time intervals (p > 0.05). CAL and associations with BCT showed greater weight loss (p < 0.05). BCT showed intratubular disinfection similar to that of BCT/CAL 25% (p > 0.05). CAL and BCT/CAL at 50% and 75% were similar and had the highest intratubular disinfection values (p > 0.05). Combinations of Bio-C® Temp with 50% or more calcium hydroxide paste provide higher alkalinization, solubility and intratubular disinfection values of the bioceramic medication, favoring its potential for clinical application.
Different dimensions of oral health literacy and tooth avulsion management: pre-post study with schoolteachers.
Fagundes FAU, Schade AC, Dias VFO … +3 more , Fraiz FC, Ferreira FM, Assunção LRDS
Braz Oral Res · 2025 · PMID 41259578 · Full text
Oral health literacy (OHL) may play a crucial role for managing traumatic dental injuries. In this pre-post study, the effect of the different dimensions of OHL on the efficacy of using an information leaflet (IL for man...
Oral health literacy (OHL) may play a crucial role for managing traumatic dental injuries. In this pre-post study, the effect of the different dimensions of OHL on the efficacy of using an information leaflet (IL for managing permanent tooth avulsion ) was assessed in elementary schoolteachers. Functional OHL was measured using the Brazilian version of the Rapid Estimate of Adult Literacy in Dentistry (BREALD-30), while interactive OHL was assessed with the Oral Health Literacy Adult Questionnaire (BOHL-AQ). Knowledge scores (KS) on avulsion management were collected at three intervals: before reading the IL (baseline), immediately post-intervention (Phase I), and 60 days post-intervention (Phase II). The effect on OHL was assessed by comparing KS means between Phase I/Baseline (acquisition) and Phases II/I (retention). Participants with high OHL/BOHL had a greater difference in mean KS values between Phase I/baseline, while those with high OHL/BREALD-30 showed a smaller difference between phases II/I. Different dimensions of OHL impacted the effectiveness of an educational intervention on managing permanent tooth avulsion with use of a leaflet.
Sugar consumption and early childhood caries: a systematic review and meta-analysis of cohort studies.
Echeverria MS, Mathias FB, Schuch HS … +4 more , Cenci MS, Correa MB, Huysmans MC, Demarco FF
Braz Oral Res · 2025 · PMID 41259577 · Full text
The aim of this systematic literature review and meta-analysis was to answer the following research question: "Is sugar consumption associated with early childhood caries among children under 6 years of age in cohort stu...
The aim of this systematic literature review and meta-analysis was to answer the following research question: "Is sugar consumption associated with early childhood caries among children under 6 years of age in cohort studies?". The following electronic databases were accessed from December 2020 to May 2025 to identify the existing literature: Bireme, Pubmed/Medline, Scielo, Scopus, and Web of Science. Studies considered eligible for this systematic review were those that investigated sugar consumption as the main exposure and early childhood caries (ECC) as the outcome. Study selection and data extraction were performed independently by two reviewers. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist for cohort studies scale. The search strategy retrieved 718 studies. After title and abstract screening, 59 were selected for full-text review, leading to the inclusion of 17 original studies in this systematic review. Finally, nine studies provided sufficient data for a meta-analysis. The association between sugar consumption and ECC was consistent across most of the cohort studies included in this review, which reported that higher sugar consumption was associated with higher prevalence of dental caries. The pooled effect estimate from the meta-analysis yielded an OR of 1.59 and a 95% CI (1.50-1.68), indicating that children who consumed sugar in early childhood were 59% more likely to develop caries compared to those who did not consume sugar. The included studies had a low risk of bias. Our systematic review and meta-analysis confirmed the association between sugar consumption and ECC in longitudinal cohort studies.
Impact of CD68, CD4, TNF-α, and COX-2 expression on disease-specific survival in Brazilian patients with OSCC.
Aquino SN, Souza LL, Bezerra HKF … +6 more , Alvarenga DG, Bonan PRF, Martins HDD, Santos-Silva AR, Lopes MA, Vargas PA
Braz Oral Res · 2025 · PMID 41259576 · Full text
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck. Studies on the inflammatory pathways that have evolved during the development of the disease remain controversial. We assessed the e...
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck. Studies on the inflammatory pathways that have evolved during the development of the disease remain controversial. We assessed the expression of inflammatory markers, such as COX (cyclooxygenase)-2, CD68, CD4, and tumor necrosis factor (TNF)-α, based on prognostic variables and disease-specific survival in patients with OSCC. Immunohistochemical analysis of COX-2, TNF-α, CD4, and CD68 was conducted in 72 patients treated surgically. Neural invasion was evaluated based on S100 expression. Disease-specific survival was assessed using Cox regression analysis. Most participants were male, with a mean age of 61 years. A total of 77.5% of patients presented with clinical stages III-IV, and 70% underwent surgery combined with radiotherapy or chemotherapy. The expression of CD68, CD4, and TNF-α was not associated with clinical variables or tumor differentiation. COX-2 expression correlated with tumor size (p = 0.01), whereas high TNF-α expression was noted in moderately/poorly differentiated OSCC. The absence of nodal involvement (hazard ratio [HR]: 0.47, confidence interval [CI]: 0.25-0.87, p = 0.001) was linked to lower death risk, whereas surgery without adjuvant radiotherapy or chemotherapy was associated with a higher risk of death (HR: 2.09, 95%CI: 1.02-4.27, p = 0.043). Multivariate analysis revealed that high COX-2 expression predicted a shorter disease-specific survival. Altogether, high TNF-α expression is prevalent in moderately/poorly differentiated OSCC, and elevated COX-2 expression correlates with larger tumor size and poorer survival in OSCC.
Dental pain among children aged 8 to 11 and associated factors: a population-based study.
Souza TO, Roberto LL, Ruas NGC … +3 more , Souto-Souza D, Paiva PCP, Ramos-Jorge ML
Braz Oral Res · 2025 · PMID 41259575 · Full text
This study aimed to identify factors associated with dental pain among schoolchildren in Diamantina, Minas Gerais, Brazil. A total of 627 children aged 8-11 years were assessed through questionnaires and clinical examina...
This study aimed to identify factors associated with dental pain among schoolchildren in Diamantina, Minas Gerais, Brazil. A total of 627 children aged 8-11 years were assessed through questionnaires and clinical examinations in both public and private schools. We employed a complex, probabilistic, two-stage cluster sampling method involving schools and classes. The sample size was calculated assuming a 50% prevalence of events or diseases, a 95% confidence level, a 5.0% margin of error, a design effect (deff) of 1.5, and a 15% non-response rate. The dependent variable, dental pain, was assessed by asking: "Have you ever had a toothache in your life?" with possible responses of "No" or "Yes." The independent variables included sociodemographic factors and dental history. Binary logistic regression was used to estimate the odds ratio (OR). Approximately 70.6% of the children reported having experienced dental pain at least once in their lives. In the final model, the likelihood of having experienced dental pain was higher among children who had either deciduous or permanent teeth restored (OR = 1.99; 95%IC: 1.19-3.29), who had a normative need for dental treatment (OR = 3.00; 95%IC: 1.96-4.58), and whose guardians perceived their oral health negatively (OR = 1.81; 95%IC: 1.19-2.75). Dental pain is a significant oral health issue among children. This pain was associated with both unfavorable normative assessments and subjective perceptions of oral health, underscoring the importance of preventive and promotive strategies for children's oral health.
Antibacterial resorbable barrier membranes with therapeutic activity for guided tissue regeneration.
Silveira LF, Collares FM, Leitune VCB … +2 more , Soares RMD, Balbinot GS
Braz Oral Res · 2025 · PMID 41221972 · Full text
The objective of this study was to develop a bioabsorbable membrane composed of poly(butylene adipate-co-terephthalate) (PBAT) with alkyl trimethyl ammonium bromide (ATAB) to provide antimicrobial properties. Membranes w...
The objective of this study was to develop a bioabsorbable membrane composed of poly(butylene adipate-co-terephthalate) (PBAT) with alkyl trimethyl ammonium bromide (ATAB) to provide antimicrobial properties. Membranes were manufactured via the solvent casting technique using chloroform solutions containing PBAT and varying concentrations of ATAB (1, 2.5, and 5% wt), with ATAB-free membranes as a control. The characterization of the membranes included assessments of contact angle, surface free energy, and degradation in distilled water over periods of one week, one month, and three months. Mechanical properties were evaluated via tensile strength, and changes in water pH were monitored from 24 hours to three months post-immersion. Cytotoxicity was assessed using gingival fibroblasts and pre-osteoblasts via the SRB assay. Antimicrobial activity was tested against Staphylococcus aureus. ATAB inclusion reduced water contact angle and increased surface free energy compared to controls (p < 0.001). The addition of 5% wt ATAB decreased the tensile strength of PBAT membranes. At one month, a reduced mass was observed for the 2.5% wt ATAB membrane. The specimens' mass was reduced for all groups after three months of immersion in water in comparison to the initial measurement, while a reduction in thickness was found in all time points, without the influence of ATAB. ATAB incorporation reduced cell viability. Antimicrobial efficacy, resulting in a > 3 log10 bacterial reduction, was observed for S. aureus at the 5% wt concentration. The addition of 2.5% wt ATAB to PBAT membranes may be a suitable strategy to generate barrier membranes with an antibacterial effect while maintaining acceptable mechanical and surface properties.
Extending regular oral hygiene reduces the incidence of upper respiratory symptoms.
Rösing CK, Cavagni J, Rotta IDS … +8 more , Sossai LL, Caetano RO, Pedroni G, Friedrich SA, Stewart B, Malheiros Z, Benítez C, Schaeffer L
Braz Oral Res · 2025 · PMID 41221971 · Full text
In this randomized controlled clinical study, the effectiveness of two different modes of extending oral hygiene - either gargling or using an oral spray - on the self-reported incidence of upper respiratory symptoms wer...
In this randomized controlled clinical study, the effectiveness of two different modes of extending oral hygiene - either gargling or using an oral spray - on the self-reported incidence of upper respiratory symptoms were evaluated, to help with the prevention of respiratory symptoms. The study was conducted in Porto Alegre, Brazil. A total of 205 individuals were enrolled and assigned to one of three groups: Control Group: brushed twice daily for two minutes with a commercially available fluoride toothpaste; Gargling Group: brushed twice daily for two minutes with a commercially available fluoride toothpaste and then gargled with a mouthwash containing 0.075% CPC (cetylpiridinium chloride); and Oral Spray Group: brushed twice daily for two minutes with a commercially available fluoride toothpaste and instructed to use an oral spray containing 0.075% CPC (3 pumps of spray applied directly into their mouth) twice daily. All subjects were asked to complete the WURSS-21 Daily Symptom Report via a diary for the 3 months duration of the study. Based on analysis of the diaries, the use of regular oral hygiene with brushing, in addition to a type that extended to the entire oral cavity, reduced the incidence and severity of upper respiratory symptoms throughout the duration of the study. Data were statistically analyzed using ANOVA (α = 0.05). Individuals using either mouthwash or spray reported approximately 20% fewer days with respiratory symptoms compared with the control group. Regular oral hygiene that extended to the whole oral cavity with either a mouthwash or an oral spray may help to reduce the incidence of upper respiratory symptoms.
Social capital and oral health-related quality of life in pregnant women using public health services.
Prates CAR, Skupien JA, Emmanuelli B … +3 more , Araujo G, Assumpção DP, Sfreddo CS
Braz Oral Res · 2025 · PMID 41221970 · Full text
Although social capital can significantly impact oral health-related quality of life (OHRQoL), evidence of this association remains limited during pregnancy. We assessed the association between individual social capital...
Although social capital can significantly impact oral health-related quality of life (OHRQoL), evidence of this association remains limited during pregnancy. We assessed the association between individual social capital and OHRQoL among pregnant women in public health services. This cross-sectional study assessed a representative sample of pregnant women grouped into 25 Brazilian public health units in 2022. Sociodemographic, individual social capital (social networks and social support), and health behaviour characteristics were collected through a questionnaire. Participants were also clinically examined for gingivitis and dental caries experience. The outcome OHRQoL was assessed using the Oral Health Impact Profile (OHIP-14) questionnaire. Multilevel Poisson regression models with a hierarchical approach were used to assess the associations between social capital and overall OHIP-14 score. The results are presented as rate ratio (RR) and 95% confidence interval (95%CI). A total of 520 pregnant women were evaluated. Pregnant women with lower social support had higher overall OHIP-14 scores (RR: 1.21, 95%CI: 1.10-1.34). However, social networks were not associated with OHRQoL (p > 0.05). High number of children, lower household income and schooling factors, alcohol consumption before pregnancy, visiting a dentist for toothache, gingivitis, and dental caries experience were also associated with higher overall OHIP-14 scores (p < 0.05). Lower social support was associated with worse OHRQoL among pregnant women. These finding suggest that quality of personal resources was of greater relevance than social networks during pregnancy.
Root canal instrumentation of artificial primary teeth with rotary and reciprocating files: a micro-CT analysis.
Chrisostomo DA, Danelon M, Furlan RD … +3 more , Duarte MAH, Mello-Moura ACV, Duque C
Braz Oral Res · 2025 · PMID 41221969 · Full text
This study compared the outcomes of two endodontic instrumentation protocols (rotary or reciprocating files), using artificial primary teeth and micro-computed tomography. Twenty-four artificial primary molars were equal...
This study compared the outcomes of two endodontic instrumentation protocols (rotary or reciprocating files), using artificial primary teeth and micro-computed tomography. Twenty-four artificial primary molars were equally distributed into two groups of 12, according to the type of instrumentation - rotary files (Sequence Baby NiTi Files©) or reciprocating files (X1-Blue File NiTi files©). The following parameters were evaluated: root canal and dentin volumes, canal transportation and centering ability, risk of root perforation, and time of instrumentation. Statistically significant differences between the two instrumentation protocols considering root canal transportation and centering ability were identified. There was no difference in dentin thickness, fractures, and cracks comparing preoperative and postoperative time points for both endodontic files. Although the time of instrumentation was shorter for reciprocating files, rotary files promoted smaller root canal enlargement. Instrumentation with reciprocating and rotary files proved generally safe for pulpectomy in primary molars, promoting a negligible reduction in dentin volume, canal transportation, and centering ability, thereby preserving dentin thickness and lowering the risk of fractures.
Influence of potentially harmful sucking habits on otitis media in children: a systematic review and meta-analysis.
Castro-Cunha AC, Moreira LV, Gonçalves IC … +5 more , Fernandes IB, Abreu LG, Paiva SM, Martins-Júnior PA, Bendo CB
Braz Oral Res · 2025 · PMID 41221968 · Full text
This study aimed to evaluate the influence of pacifier use, bottle feeding, and finger/thumb sucking on the occurrence of otitis media in children. Searches were conducted in grey literature and six databases: Web of Sci...
This study aimed to evaluate the influence of pacifier use, bottle feeding, and finger/thumb sucking on the occurrence of otitis media in children. Searches were conducted in grey literature and six databases: Web of Science, Cochrane Library, LILACS, Scopus, MEDLINE/PubMed, and EMBASE, from inception through May 2025. Observational studies investigating the association between harmful sucking habits and otitis media in newborns, infants, preschoolers, and older children were included. Risk of bias was assessed using the Joanna Briggs Institute tool. Meta-analysis results were reported as odds ratios (ORs) with 95% confidence intervals (CIs), and the certainty of evidence was also evaluated. A total of 36 studies were included, most of which were cohort studies (n = 14), with sample sizes ranging from 46 to 35,613. Eleven studies were incorporated into meta-analyses. Children who used a pacifier were 1.17 times more likely to develop otitis media (95%CI: 1.00-1.33) and 1.54 times more likely to develop acute otitis media (95%CI: 1.01-2.36) compared to those who did not use a pacifier. No significant association was found between bottle feeding and otitis media (OR = 0.83; 95%CI: 0.59-1.17). Most studies did not report a significant association between finger or thumb sucking and otitis media. The certainty of evidence was rated as very low. These findings suggest that pacifier use may increase the likelihood of developing otitis media, particularly acute otitis media, with potentially relevant implications.
Biological evaluation of solutions from bioglass, bioglass modified with cobalt, and calcium hydroxide.
Amadeu JR, Silva IJP, Goto J … +7 more , Reis-Prado AHD, Caiaffa KS, Crovace MC, Cintra LTA, Delbem ACB, Duque C, Benetti F
Braz Oral Res · 2025 · PMID 41221967 · Full text
This study evaluated the cytotoxicity, biocompatibility, and bioactivity potential of bioglass solutions (F18 and F18 with cobalt; F18-Co) compared to Ca(OH)2 solution, to determine their suitability for use in vital pul...
This study evaluated the cytotoxicity, biocompatibility, and bioactivity potential of bioglass solutions (F18 and F18 with cobalt; F18-Co) compared to Ca(OH)2 solution, to determine their suitability for use in vital pulp therapy. F18 bioglass was prepared, with a part being doped with cobalt. The solutions were prepared at a 1:10 powder-to-water ratio. L929 fibroblasts viability was assessed (MTT assay; 24 and 48-h). Tubes containing fibrin sponges embedded with either the solutions or saline (control) were prepared (16 tubes/group) and immediately implanted into 16 rats (4 tubes/rat). At 7 and 30 days, the euthanized rat specimens were analyzed for inflammation and bioactivity. The ANOVA with Tukey's test, or Kruskal-Wallis with Dunn's test was performed (p < 0.05). Undiluted, 1:2, and 1:4 diluted solutions reduced cell viability at 24-h (p < 0.05). The 1:8 and 1:16 dilutions of F18 and F18-Co exhibited cell viability similar to that of the control (p > 0.05), whereas Ca(OH)2 was cytotoxic (p < 0.05). At 48-h, F18 dilutions (undiluted, 1:2, and 1:4) exhibited similar results to the control (p > 0.05). F18-Co at 1:8 and 1:16 dilutions increased cell viability compared to Ca(OH)2 (p < 0.05) and were similar to the control (p > 0.05). On day 7, moderate-to-severe inflammation (p > 0.05) and thick fibrous capsule were observed. On day 30, mild inflammation was observed in the control and F18-Co groups, moderate inflammation in F18 (p < 0.05), and mild inflammation in Ca(OH)2 (p > 0.05). The fibrous capsule was thin. None of the materials exhibited positive structure in von Kossa and polarized light analysis. The F18 and F18-Co solutions are cyto- and biocompatible; however, no bioactivity was observed.
Social interest in publications on bruxism: an altmetric analysis.
Rocha AO, Anjos LMD, Zatt FP … +4 more , Santos PS, Vitali FC, Henriques B, Cardoso M
Braz Oral Res · 2025 · PMID 41221966 · Full text
Metrics derived from online social platforms indicate current interest in a specific topic. This study aimed to analyze the characteristics and social interest in scientific publications on bruxism using an altmetric ana...
Metrics derived from online social platforms indicate current interest in a specific topic. This study aimed to analyze the characteristics and social interest in scientific publications on bruxism using an altmetric analysis. A search was conducted in August 2024 in the Dimensions database. The following data were extracted: altmetric attention score (AAS), citations, year, language, access type, study design, topic (general objective and age group), journal, country, institution, and authors. VOSviewer was used to generate collaborative networks, whereas Google Trends was consulted to assess public interest in bruxism-related research. A Spearman correlation analysis was performed to establish the relationship between AAS and citations. A total of 196 studies published between 1992 and 2024 were included. The most widely accessed study had an AAS of 393. Significant interest in bruxism was observed among Mendeley, news outlets, and X users. Most studies were observational (n = 99), addressing the etiologic factors of bruxism (n = 75) and focusing primarily on the adult population (n = 148). The Journal of Oral Rehabilitation stood out as the most relevant journal (n = 36). Most articles were published in Brazil (n = 40), and Lobbezoo was the most frequent author (n = 27). VOSviewer revealed significant collaborations among authors. Most studies were not openly accessible (n = 105). A very weak positive correlation (r = 0.042) was observed between AAS and the number of citations. This study highlighted a social interest in scientific publications on bruxism, particularly those addressing etiologic factors.
Effect of maintaining apical patency with a CM instrument on apical transportation and centering ability.
Santos CCD, Díaz Zamalloa SI, Gavini G … +2 more , Chilvarquer I, Caldeira CL
Braz Oral Res · 2025 · PMID 41221965 · Full text
The aim of this study was to assess the impact of the apical patency technique on apical transportation and centering ability of a controlled memory (CM) instrument in the apical region using cone-beam computed tomograph...
The aim of this study was to assess the impact of the apical patency technique on apical transportation and centering ability of a controlled memory (CM) instrument in the apical region using cone-beam computed tomography (CBCT). Sixty distobuccal canals of extracted maxillary molars were assigned to three groups (n = 20) based on the patency length achieved using the Easy ProDesign Logic (EPL) 25.01 file: Group A - 1 mm beyond the apical foramen; Group B - at the apical foramen; and Group C - 1 mm short of the apical foramen (no patency). Each group was then subdivided into two subgroups (n = 10) according to the working length used for root canal preparation with the EPL 25.05 file: A1, B1, C1-I, and C1-II - 1 mm short of the apical foramen and A2, B2 - at the apical foramen. CBCT images were acquired at three time points: pre-patency, post-patency, and post-instrumentation. The scanned images were analyzed using the E-VOL DX software. No statistically significant difference in apical transportation was found between the groups after patency or after instrumentation (p < 0.05), irrespective of the measurement levels (0.5, 1, and 2 mm short of the apical foramen). A significant difference in the centering ability of the patency instrument was observed only at 2 mm short of the foramen (p < 0.05). The B2 group exhibited a higher centering ability, with a statistically significant difference compared to the A2 group (p < 0.05), observed only at 0.5 mm short of the foramen. In conclusion, maintenance of apical patency using the EPL instrument had no influence on apical transportation; however, it may slightly affect the centering ability of the root canal.
Changes in biosafety practices of Brazilian orthodontists after the COVID-19 pandemic: a cross-sectional study.
Santos LG, Santos Júnior EDM, Carvalho RP … +5 more , Degrazia FW, Cançado RH, Henriques JFC, Garib D, Neves LS
Braz Oral Res · 2025 · PMID 41221964 · Full text
The aim of this study was to assess the biosafety practices adopted during the COVID-19 pandemic that persisted in post-pandemic orthodontic clinical routines. In this cross-sectional study, 722 Brazilian orthodontists w...
The aim of this study was to assess the biosafety practices adopted during the COVID-19 pandemic that persisted in post-pandemic orthodontic clinical routines. In this cross-sectional study, 722 Brazilian orthodontists who were in the early phase of the pandemic, and 203 from the later phase, respectively, answered a 45-item questionnaire addressing basic personal information, use of personal protective equipment, biosafety protocols, and COVID-19 incidence. Descriptive statistics and chi-square tests were used to analyze the data. Most participants were infected with the coronavirus (from 10.1% to 65%). While 52.4% perceived providing care as very risky during the pandemic, this perception shifted to decreased to a moderate level of risk in the late phase of the pandemic (40.4%). The use of protective face masks/face shields decreased from 51.7% to 25.1%, as well as the use of disposable coats (from 77.1% to 45.8%). Many orthodontists discontinued the use of PFF2/N95 masks and reverted to wearing surgical masks again. Most orthodontists disinfected orthodontic bands, and photographic retractors through manual washing and autoclaving. Most participants preferred to clean their orthodontic pliers with 70% alcohol. A decline in orthodontists' concern about biosafety during clinical appointments was observed in the late phase of the pandemic. Moreover, the need for greater specific care still persists, especially regarding the proper use of disposable coats, face shields, and surgical masks.
Comparative in vivo evaluation of cross-linked and non-cross-linked collagen membranes for guided bone regeneration in rat calvarial defects.
Baggio AMP, Viotto AHA, Delamura IF … +6 more , Bizelli VF, Jacob RGM, Deus CBD, Neiva RF, Faverani LP, Bassi APF
Braz Oral Res · 2025 · PMID 41221963 · Full text
Guided bone regeneration (GBR) is a critical strategy for repairing large bone defects. This study aimed to assess the osteopromotive potential of a porcine cross-linked collagen membrane in critical calvaria-defects in...
Guided bone regeneration (GBR) is a critical strategy for repairing large bone defects. This study aimed to assess the osteopromotive potential of a porcine cross-linked collagen membrane in critical calvaria-defects in rats. Seventy-two rats were divided into three groups: blood clot (CG - negative control), Bio-Gide® membrane (BG - positive control), and Ossix Plus® membrane (OSX - test). The defects were covered according to each group, and the experimental times were 7, 15, 30, and 60 days postoperatively. The collected samples were evaluated by histometric analysis, inflammatory profile, immunohistochemistry, and micro-computed tomography (micro-CT). At 7 days, no significant differences in bone neoformation were observed. At 15 days, the OSX group showed increased new bone formation compared to CG (p = 0.031). At 30 days, the BG group exhibited the most significant increase compared to both OSX (p < 0.001) and CG (p < 0.001). At 60 days, OSX demonstrated the highest osteopromotive potential, significantly outperforming CG (p < 0.001) and BG (p < 0.001). MicroCT analysis revealed that the OSX group had a bone volume (BV) of 17.33 ± 1.74 mm3, significantly higher than BG (8.06 ± 1.26 mm3, p < 0.05). The cross-linked collagen membrane was biologically more favorable for bone regeneration being a promising option for GBR procedures.
Moderating effect of social capital on income and oral health-related quality of life during pregnancy.
Pacheco SC, Araujo G, Segatto MC … +3 more , Knorst JK, Tomazoni F, Emmanuelli B
Braz Oral Res · 2025 · PMID 41124518 · Full text
This cross-sectional study aimed to evaluate the moderating role of social capital in the relationship between income and oral health-related quality of life (OHRQoL) among pregnant women. The study was conducted using a...
This cross-sectional study aimed to evaluate the moderating role of social capital in the relationship between income and oral health-related quality of life (OHRQoL) among pregnant women. The study was conducted using a random sample of pregnant women registered with the public health system in southern Brazil. Women with sensory or cognitive impairments, non-Brazilian nationality, or high-risk pregnancies were excluded. The Oral Health Impact Profile (OHIP-14) was used to assess OHRQoL. Social capital was evaluated through "perceived social support" and "pregnancy group attendance." The monthly household income was assessed in Brazilian Reais and categorized as either high (≥ 1,000 BRL) or low (< 1,000 BRL). The moderating role of social capital on the relationship between income and OHRQoL was tested using multilevel Poisson regression analysis. The results are presented as rate ratio (RR) with 95% confidence intervals (CI). A total of 520 pregnant women were assessed, with a response rate of 93%. Approximately 25.6% had low income. Both social capital variables demonstrated a moderating effect on the relationship between income and OHRQoL. Among pregnant women with a low household income, those without social support and those who did not attend pregnancy groups had 44% (RR = 1.44, 95%CI: 1.22-1.72) and 22% (RR = 1.22, 95%CI: 1.05-1.42) higher overall OHIP-14 scores, respectively, compared to their counterparts. This means that social support and group attendance substantially mitigate the negative effects of low income on OHRQoL. Our findings highlight the potential role of social capital promotion in this population.
Orofacial antinociceptive effect of a novel 2-amino-thiophene derivative and its possible targets of action.
Silva AJD, Silva PRD, Pires HFO … +8 more , Dias AL, Felipe CFB, Mendonça-Junior FJB, Nayarisseri A, Alves AF, Scotti MT, Golzio AMFO, Castro RD
Braz Oral Res · 2025 · PMID 41124517 · Full text
Orofacial pain impairs quality of life, and current therapies, limited in efficacy and associated with adverse effects, drive the search for new treatments. Thiophene derivatives exhibit remarkable therapeutic properties...
Orofacial pain impairs quality of life, and current therapies, limited in efficacy and associated with adverse effects, drive the search for new treatments. Thiophene derivatives exhibit remarkable therapeutic properties, including antinociceptive and anti-inflammatory activities, with recent studies demonstrating superior activity compared to commercial drugs, highlighting their relevance in the design of novel agents. This study investigated the antinociceptive effect of the thiophene derivative 2-[(4-diethylamino-benzylidene)-amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile (7CN03) and its possible mechanisms of action. In vivo tests were performed on male mice (n = 6 per group), and nociception was induced by formalin, capsaicin, and glutamate 1 h after treatment. Facial rubbing was used as a parameter to measure nociceptive behavior. 7CN03 exhibited significant action during the neurogenic phase of the formalin test at different doses (1 mg/kg, 0.1 mg/kg, and 0.01 mg/kg), reducing nociceptive behavior by up to 56%. During the inflammatory phase, the 1 mg/kg dose exerted an antinociceptive effect, reducing nociceptive behavior by 32% (p < 0.05). In the glutamate test, 7CN03 blocked nociception by up to 90% (p < 0.001), and in the capsaicin test, it reduced nociceptive behavior by up to 74%. Molecular docking studies predicted higher binding affinity of 7CN03 for µ-opioid (-97.00 Kcal/mol), TRPV1 (-87.79 Kcal/mol), and NMDA (-104.86 Kcal/mol) receptors when compared with cocrystallized ligands. The findings suggest that the evaluated thiophene derivative exhibits an orofacial antinociceptive effect, with a mechanism of action likely mediated by opioid, transient receptor potential vanilloid, and glutamatergic receptors.
Translation and validation of the OHIP-14 Oral Health Impact Profile into the Quechua language of Peru.
Leon-Rodriguez JA, Espinoza-Salcedo M, Gutierrez-Polanco YM … +3 more , Aquepucho-Bellota RW, Leon-Rodriguez JD, Leon-Plasencia JL
Braz Oral Res · 2025 · PMID 41124516 · Full text
The aim of this study was to translate and validate the 14-item Oral Health Impact Profile (OHIP-14) into the Collao variant of the Quechua language for the population of southern Peru. A cross-sectional instrumental stu...
The aim of this study was to translate and validate the 14-item Oral Health Impact Profile (OHIP-14) into the Collao variant of the Quechua language for the population of southern Peru. A cross-sectional instrumental study was carried out with 288 participants of both sexes aged between 18 and 65 years (M = 37.53 years; SD = 10.38) who were residents of the department of Cusco, Peru. A convenience sampling method was used. The cultural adaptation process included initial translation, back-translation, review by a committee, focus group evaluation for comprehension and clarity of the items, and a pilot test to ensure the cultural adequacy of the questionnaire. Content validity was evaluated by three evaluators using Aiken's V coefficient. The internal structure was assessed through confirmatory factor analysis (CFA), which tests a three-factor model. The fit indices demonstrated an acceptable model fit, with χ2 = 156.25 (df = 74), RMSEA = 0.062 (90%CI: 0.049-0.076), CFI = 0.999, and TLI = 0.999. The standardized factor loadings exceeded 0.70 for all the items. The corrected item-total correlations indicated strong internal consistency. Reliability was assessed with Cronbach's alpha, which is a high value across all dimensions. The evaluators' assessment demonstrated a high level of agreement for all the items, with Aiken's V coefficient above 0.70. This finding demonstrates that the OHIP-14 is a valid and reliable instrument for the Quechua-speaking population of the Collao variant in Cusco. The study received approval from an ethics committee and adhered to the ethical principles of the Declaration of Helsinki.
Impact of artifact reduction on dimensional accuracy of sealing materials for furcal perforations in CBCT.
Borges CC, Mazzi-Chaves JF, Pécora JD … +5 more , Azevedo BC, Rossi-Fedele G, Bueno M, Sousa-Neto MD, Estrela C
Braz Oral Res · 2025 · PMID 41124515 · Full text
This study aimed to evaluate the impact of the blooming artifact reduction (BAR) algorithm on the measurement of various sealing materials (Biodentine, MTA ProRoot, MTAFlow, and amalgam) for furcal perforation repair usi...
This study aimed to evaluate the impact of the blooming artifact reduction (BAR) algorithm on the measurement of various sealing materials (Biodentine, MTA ProRoot, MTAFlow, and amalgam) for furcal perforation repair using cone-beam computed tomography (CBCT). A total of 105 extracted human mandibular first and second molars were prepared and root-filled. Furcal perforations were created, and the specimens were randomly organized into five groups based on the sealing material used: (1) Biodentine, (2) MTA ProRoot, (3) MTAFlow, (4) Amalgam, and (5) Control (no sealing material). After setting, the specimens were embedded in wax, and the crowns were sectioned to measure the diameter of the sealing materials using a digital micrometer. CBCT scans were acquired using the Prexion 3D Elite® CT scanner. The dimensional measurements of sealing materials on the CBCT images was measured using DICOM files and the e-Vol DX software measurement tool, configured to thousandths of a millimeter. BAR algorithms were applied as follows: BAR 3 for the control group, Biodentine, and MTAFlow; BAR 2 for MTA ProRoot; and BAR 1 for amalgam. Statistical analysis was performed using ANOVA and Tukey's test with a significance level of 5%. No significant differences were observed between the diameters of sealing materials measured using the micrometer and those obtained from CBCT images processed with BAR algorithms (Biodentine, MTA ProRoot, MTAFlow, and amalgam). The BAR algorithm in the e-Vol DX software preserved the dimensional accuracy of CBCT images for the tested sealing materials.
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