Braz Oral Res [JOURNAL]
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200 papers
Effect of dentition status on perceived mobility limitation among older Brazilian adults: a cohort study.
Andrade FB, Freitas RL, Duarte YAO … +1 more , Santos JLF
Braz Oral Res · 2025 · PMID 40929405 · Full text
This study aimed to evaluate the longitudinal effect of dentition status on the perceived mobility limitation of community-dwelling Brazilian older adults. This cohort study used data from individuals who participated in...
This study aimed to evaluate the longitudinal effect of dentition status on the perceived mobility limitation of community-dwelling Brazilian older adults. This cohort study used data from individuals who participated in the second (2006), third (2010), and fourth (2015) waves of the Health Well-being and Aging Study, conducted in the urban region of the city of São Paulo, Brazil, with adults aged 60 years and older. Mobility limitation was assessed in all waves according to reports of difficulty in performing seven activities, with higher scores representing a higher number of limitations. The independent variables of interest were number of teeth, use of dental prostheses, impact of oral health on functionality, and presence of periodontal pockets. Oral health measures were assessed by dentists, in all waves, during a clinical oral examination. The generalized linear mixed model with a Poisson distribution was used to assess longitudinal associations. All the variables were treated as time-varying in the analysis. Older adults with 20 or more teeth had a lower risk of mobility limitation than edentulous individuals, while the impact of oral health on functionality was associated with an increased risk. Similar findings were observed among dentate individuals. Periodontal disease was not associated with the outcome in dentate individuals. The associations were constant over time. The number of teeth and the impact of oral health on functionality are risk factors for mobility limitation, underscoring the importance of maintaining functional dentition for healthy aging.
Evaluating microbial load on dental curing lights and the impact of protective barriers on resin composites.
Alvarez-Leite ME, Alves FA, Cardozo AF … +5 more , Ribeiro PAGP, Gomes VM, Vieira CD, Lana MA, Antunes ANDG
Braz Oral Res · 2025 · PMID 40929404 · Full text
The contamination of dental curing light tips was evaluated before and after treatment and after their use and disinfection. The influence of a plastic protective barrier over the flexural strength and the modulus of ela...
The contamination of dental curing light tips was evaluated before and after treatment and after their use and disinfection. The influence of a plastic protective barrier over the flexural strength and the modulus of elasticity of resin composites were also analyzed. Microbiological sampling was conducted at initial contamination (T0), in Log 10 CFU/4 mL; after dental treatment (T1); and after disinfection with 70% ethanol (v/v) (T2). The results were analyzed by descriptive statistics and analysis of variance. The flexural strength and the modulus of elasticity analyses were performed using bar-shaped test specimens of three commercial resin composites with and without barriers, and the tests were subjected to a statistical normality test. Turbidity was observed in the media in 60.7% of the tubes at T0, 100.0% at T1, and 57.1% at T2. The microbial contamination was similar at T0 and T2, but a significant increase was observed at T1. The recovered microbial load differed significantly between T1 and T2 (p < 0.05). The results of the flexural strength and modulus of elasticity analyses showed no significant differences with or without a barrier for any of the different colors of resin, polymerization time, or the three resins. Under the present experimental conditions, 70% ethanol significantly reduced the levels of microbial contamination, but it did not guarantee the inactivation of all microbial cells. The use of plastic protective barriers did not alter the flexural strength or the modulus of elasticity of any of the tested resin composites, indicating that they are a safe and viable measure to prevent cross-contamination when using a dental curing light.
Effectiveness of customized healing abutments in immediate implants: a randomized clinical trial.
Dutra MDZ, DE Carli JP, Dallepiane FG … +6 more , Facenda JC, Silva PRPD, Dal Bello Y, DOGENSKi LC, DI Domenico MB, Corazza PH
Braz Oral Res · 2025 · PMID 40929403 · Full text
This study evaluated the influence of a customized healing abutment (CHA) placed on immediate implants. It also assessed bone ridge volume, keratinized mucosal collar, and postoperative pain. Thirty-one patients needing...
This study evaluated the influence of a customized healing abutment (CHA) placed on immediate implants. It also assessed bone ridge volume, keratinized mucosal collar, and postoperative pain. Thirty-one patients needing tooth extraction and immediate implant were selected. Gingival papilla height, bone ridge volume, and keratinized mucosal collar thickness were measured using a millimeter periodontal probe and a dry-point caliper. A visual analog scale (VAS) was applied to determine postoperative pain. Study participants were randomly assigned to a control group (n = 15, with extraction, immediate implant placement, alveolar gap filling with a bovine bone graft, PTFE barrier, and suture) and an experimental group (n = 16, with extraction, immediate implant placement, gap filling with a bovine bone graft, and CHA). The healing abutments were prepared before surgery and customized during the procedure. The data were tabulated and statistically analyzed using the Mann-Whitney test (α = 0.05). The "changes in the papilla" outcome presented a statistical difference, and the control group showed higher values than those of the experimental group (p = 0.04). The remaining characteristics demonstrated no statistical differences between the groups (p > 0.05). CHA and the barriers exhibited similar behavior in maintaining bone ridge and keratinized mucosal thickness. CHA proved more effective than the conventional barrier in preserving the gingival papilla, with the distance measured three months post-surgery averaging 17% greater than the pre-surgical measurement.
Response of cultured primary gingival and periodontal ligament cells to angiotensin II and IL1β challenges.
Garbieri TF, Dionísio TJ, Colombini-Ishikiriama BL … +6 more , Silva RAD, Lara VS, Oliveira SHP, Fernandes MH, Greene AS, Santos CF
Braz Oral Res · 2025 · PMID 40929402 · Full text
Angiotensin II (Ang II) releases inflammatory mediators from several cell types. The objective of this study was to investigate the potential of Ang II to induce mRNA expression of inflammatory mediators in primary cultu...
Angiotensin II (Ang II) releases inflammatory mediators from several cell types. The objective of this study was to investigate the potential of Ang II to induce mRNA expression of inflammatory mediators in primary cultured fibroblast-like cells isolated from gingival and periodontal ligament tissues. A synergistic effect of co-treatment with Ang II and Interleukin-1β (IL1β) on the mRNA expression of inflammatory mediators was explored. Immunophenotyping of STRO-1, Ang II type 1 receptor (AT1R), and Ang II type 2 receptor (AT2R) was performed using flow cytometry. Cell cultures were challenged with Ang II (1 µM) for 3, 6, and 24 h with or without co-treatment with IL1β (0.1 ng/mL) for 24 h. mRNA expression of inflammatory mediators was determined using qPCR. We present, for the first time, precise quantification of AT1R and AT2R in human gingival and periodontal fibroblast-like cell types; the percentage of positive immunostaining compared to the total cell population varied from 3.35% to 5.29% for AT1R and 2.97% to 4.57% for AT2R. Ang II slightly upregulated IL6 and CCL2/MCP1 mRNA expression in gingival cells and IL8 and PTGS2/COX2 in periodontal ligament cells. IL1β upregulated IL8, IL6, CCL2/MCP1, PTGS2/COX2, and IL1β mRNA in both cell types. Co-treatment with Ang II and IL1β did not show a synergistic effect. Ang II showed a low potential to induce mRNA of inflammatory mediators, most likely owing to the low percentage of Ang II receptors in such cells and no synergistic effect with the co-treatment with IL1β.
Gender trends in authorship of randomized clinical trials in dentistry.
Prado MC, Dotto L, Agostini BA … +1 more , Onofre RS
Braz Oral Res · 2025 · PMID 40929401 · Full text
The aim of the study was to explore female authorship in various aspects of randomized controlled trials (RCTs) in dentistry. A search was performed in PubMed for RCTs, in dentistry, indexed from 12/31/2016 to 12/31/2021...
The aim of the study was to explore female authorship in various aspects of randomized controlled trials (RCTs) in dentistry. A search was performed in PubMed for RCTs, in dentistry, indexed from 12/31/2016 to 12/31/2021. Only studies in English were considered. Data selection and extraction were performed by two authors and the following data collected: year of publication, journal, subject, number and names of authors, and country and gender (Genderize website) of the first 10 authors. Descriptive analyses, graphs, and maps were generated. Poisson regression assessed the influence of continent and year of publication on the presence of women as first or last authors. The results were presented as prevalence ratios (PR) and 95% confidence intervals (95%CI). A total of 844 RCTs and 4,305 authors (2,372 men and 1,662 women) were included. Gender disparity increases as the order of authorship advances. Among first authors, men represent 50.59% and women 44.08%, whereas among last authors, they account for 61.92% and 34.03%, respectively. Analyses showed no association between year of publication and the presence of women as authors. There were fewer women as first authors in Europe (PR: 0.82, 95%CI: 0.68-0.99) and as last authors in Europe and Asia (PR: 0.68, 95%CI: 0.53-0.87 and PR: 0.79, 95%CI: 0.63-0.99, respectively). The findings highlight a lower presence of female authors in all aspects analyzed in the RCTs, especially in last authorship. Also, there has been no indication of improvement in recent years. Female participation in RCTs is crucial not only for gender equity but also as a means to enhance the quality and relevance of clinical data for decision-making.
Proanthocyanidin associated to vitamin E or palm oil on initial enamel erosion: in situ and in vitro study.
Martins DDS, Boteon AP, Silva TTD … +7 more , Sabino JF, Ionta FQ, Oliveira AA, Honório HM, Buzalaf MAR, Carvalho TS, Rios D
Braz Oral Res · 2025 · PMID 40929400 · Full text
This in vitro study evaluated the effect of proanthocyanidin, palm oil, and vitamin E against initial erosion. Bovine enamel blocks (n = 140) were divided into 14 groups: C+_SnCl2/NaF/Am-F-containing solution (positive c...
This in vitro study evaluated the effect of proanthocyanidin, palm oil, and vitamin E against initial erosion. Bovine enamel blocks (n = 140) were divided into 14 groups: C+_SnCl2/NaF/Am-F-containing solution (positive control); C-_deionized water (negative control); O_palm oil; P6.5_6.5% proanthocyanidin; P2_2% proanthocyanidin; E_Vitamin E (97.8% oily tocopherol acetate); OP6.5_palm oil + 6.5% proanthocyanidin; P6.5O_6.5% proanthocyanidin + palm oil; OP2_palm oil + 2% proanthocyanidin; P2O_2% proanthocyanidin + palm oil; EP6.5_Vitamin E + 6.5% proanthocyanidin; P6.5E_6.5% proanthocyanidin + Vitamin E; EP2_Vitamin E + 2% proanthocyanidin; P2E_2% proanthocyanidin + Vitamin E. The acquired enamel pellicle (AEP) was previously formed in situ for 30 min. The specimens were treated in vitro with the solutions (500 µL, 30s). Then, the blocks were maintained for an additional hour in oral cavity to develop the modified AEP. The blocks were immersed in 0.5% citric acid (pH 2.5) during 30s. The response variable was the percentage of surface hardness loss (%SHL). Data were analyzed by one-way ANOVA and Fisher's LSD test (p<0.05). P6.5E (12±7_%SHL) was the only group that promoted similar protection to C+ (11±8_%SHL). O (17±13_%SHL), P2 (20±10_%SHL), OP6.5 (19±12_%SHL), P2O (21±13_%SHL), P6.5E (12±7_%SHL), and P2E (19±9_%SHL) exhibited %SHL similar to both C+ and C- (25±10_%SHL) groups (p<0.05). P6.5 (23±11_%SHL), E (27±8_%SHL), P6.5O (24±13_%SHL), OP2 (27±12_%SHL), EP6.5 (24±11_%SHL), and EP2 (26±11_%SHL) were different to C+ and similar to C-. It was concluded that the combination of 6.5% proanthocyanidin and vitamin E (P6.5E) was the most effective strategy against enamel erosion, aligning closely with the positive control.
Influence of residual buccal bone thickness in dehiscence defects on osseointegrated dental implants in healed sites: an experimental in vivo study.
Freire GCB, Gonçalves PF, Pimentel SP … +3 more , Nociti Júnior FH, Casati MZ, Gurgel BCV
Braz Oral Res · 2025 · PMID 40929399 · Full text
This study aimed to histomorphometrically evaluate the effect of guided bone regeneration (GBR) and two implant surfaces on the thickness and height of newly formed bone in dehiscence defects around titanium implants. Th...
This study aimed to histomorphometrically evaluate the effect of guided bone regeneration (GBR) and two implant surfaces on the thickness and height of newly formed bone in dehiscence defects around titanium implants. Three premolars and the first bilateral molar were extracted from ten adult mongrel dogs, and 40 buccal bone dehiscences measuring 5 mm in height and 4 mm in width were created using a University of North Carolina (UNC) periodontal probe to confirm the dimensions. Forty implants were randomly assigned to one of four groups: oxidized implant surfaces (OIS, n = 10), turned/machined implant surfaces (TIS, n = 10), OIS + GBR (n = 10), and TIS + GBR (n = 10). After 3 months, the dogs were euthanized, and the blocks containing the implants and adjacent bone were processed for non-decalcified histological analysis. Statistical analysis was performed using two-way ANOVA and the Pearson correlation (p = 0.05). The results showed that GBR significantly influenced both the vertical (height) and horizontal (thickness) dimensions of the newly formed bone (p < 0.001). Strong positive correlations were observed between the thickness and height of newly formed bone at the base of the defect, as well as between the thickness of the bone at the base of the defect and the thickness of newly formed bone in the central region of the defect. No significant correlations were found between implant surface type and bone formation. Bone regeneration occurred in both the vertical and horizontal directions, with greater bone growth in GBR-treated groups, irrespective of implant surface type (oxidized or turned).
Salivary flow rate in children and teenagers with Down syndrome: Systematic review and meta-analysis.
Ramírez-Carmona W, Díaz-Fabregat B, Chaves-Neto AH … +3 more , Monteiro DR, Pessan JP, Nakamune ACMS
Braz Oral Res · 2025 · PMID 40929398 · Full text
The purpose of our review was to group the evidence and attempt to provide a consensus on the behavior of salivary flow rate in patients with Down syndrome. Observational studies evaluating salivary flow rate in children...
The purpose of our review was to group the evidence and attempt to provide a consensus on the behavior of salivary flow rate in patients with Down syndrome. Observational studies evaluating salivary flow rate in children and teenagers with Down syndrome compared with non-syndrome individuals were selected. Ten sources of information were researched. The risk of bias was assessed by using the Newcastle Ottawa Scale tool . Inverse Variance was ty the SMD (95% Confidence Interval). The certainty of the evidence was determined according to the GRADE approach. Fourteen studies were evaluated. The results showed, with a very low certainty of evidence, that children and teenagers with Down syndrome present a lower salivary flow rate compared with non-syndrome controls (SMD: -1.71, 95%IC: -2.81; -0.60, p < 0.05), with significant differences in the saliva collection methods (p < 0.05) (Unstimulated saliva, SMD -5.07, 95%CI: -7.96; -2.18, p < 0.01; Stimulated saliva, SMD -0.80, 95%IC: -1.78; 0.17, p = 0.11). The behavior of the salivary flow rate is not significantly different between the age groups (p = 0.60) (up to 5 years old, SMD -1.85, 95%CI: -2.90; -0.81, p < 0.01; 2 to 18 years old, SMD -1.51, 95%CI: -2.24; -0.78, p < 0.01), and the sex (p = 0.70) (Male, SMD -1.77, 95%CI: -2.39; -1.16, p < 0.01; Female, SMD -1.53, 95%CI: -2.58; -0.48, p < 0.01). Children and teenagers with Down syndrome present a lower salivary flow rate with an unstimulated saliva collection method compared to non-syndrome.
Accuracy of smartphone photographs for detecting active carious lesions in orthodontic patients.
Takahama RK, Dettmer BS, Nagipe LL … +3 more , Marquezan PK, Alves LS, Zenkner JEDA
Braz Oral Res · 2025 · PMID 40929397 · Full text
Advancements in digital media have driven the study and use of photographic records as a diagnostic method for carious lesions, with smartphone images being widely utilized across various health fields. This study aimed...
Advancements in digital media have driven the study and use of photographic records as a diagnostic method for carious lesions, with smartphone images being widely utilized across various health fields. This study aimed to evaluate the diagnostic accuracy of smartphone photography for detecting active caries in orthodontic patients. The sample comprised 100 individuals of both sexes, aged 11 to 46 years, who were undergoing fixed orthodontic treatment. Following professional tooth cleaning and drying, patients underwent a visual-tactile clinical examination for caries detection, which served as the gold standard. Digital photographs were then taken using a smartphone camera in five views: frontal, right and left lateral, and upper and lower occlusal. The diagnostic parameters-sensitivity, specificity, accuracy, positive predictive value (PV+), and negative predictive value (PV-)-were calculated for the photographic method relative to the clinical examination. The prevalence of active caries in the sample was 74%. The smartphone photographs correctly identified 66 of the 74 individuals with active caries according to the gold standard. However, only 4 of the 26 sound patients were correctly identified. These findings correspond to the following diagnostic parameters: sensitivity, 89%; specificity, 15%; accuracy, 70%; PV+, 75%; and PV-, 33%. In conclusion, the photographic method demonstrated high sensitivity and satisfactory accuracy in detecting caries in patients undergoing fixed orthodontic therapy. However, the low specificity observed suggests a tendency to overdiagnose sound teeth.
Accessibility for people with motor disabilities at CEOs in Brazil: an ecological study.
Lima Júnior DA, Campos MLR, Costa EM … +5 more , Queiroz RCS, Nunes AMM, Figueiredo N, Goes PSA, Thomaz EBAF
Braz Oral Res · 2025 · PMID 40767662 · Full text
The objective was to compare physical accessibility indicators for people with motor disabilities (PwMD) at dental specialty centers (acronym in Portuguese - CEO) across Brazil during the two evaluation cycles of the Acc...
The objective was to compare physical accessibility indicators for people with motor disabilities (PwMD) at dental specialty centers (acronym in Portuguese - CEO) across Brazil during the two evaluation cycles of the Access and Quality Improvement Program (acronym in Portuguese - PMAQ) for CEOs. This ecological study utilized secondary data from the external evaluation of PMAQ-CEO in Cycle I (C1), conducted in 2014, and Cycle II (C2), conducted in 2018, including all CEOs that participated in both cycles (n = 889). The structural items analyzed included corridors and doors adapted for wheelchairs, functional wheelchairs, access ramps with handrails, and bathrooms adapted for PwMD. Latent class transition analysis was applied to identify patterns in physical accessibility among CEOs, selecting the latent status (LS) model based on conceptual interpretability and goodness of fit. The final model identified five LS, labeled as follows: LS1 (most accessible); LS2 (inappropriate doors and bathrooms); LS3 (inappropriate ramps and bathrooms); LS4 (wheelchair unavailability); and LS5 (least accessible). In C1, 33.9% of the CEOs were highly accessible, while 17% were minimally accessible. In C2, these proportions shifted to 69.7% for highly accessible and 6% for minimally accessible. When analyzing the two PMAQ-CEO cycles, improvements in physical accessibility indicators were observed across Brazilian CEOs: corridors (9.7% increase) and doors (4.9%) adapted for wheelchairs; functional wheelchairs (15.7%); access ramps with handrails (38.7%); and bathrooms adapted for PwMD (19.6%). It may be concluded that physical barriers to PwMD in Brazilian CEOs were significantly reduced between 2014 and 2018, improving physical accessibility.
Oral manifestations of COVID-19 vaccinated individuals, post-infection, and different variants: a Brazilian population study.
Melo LDC, Santos JAD, Silveira BB … +6 more , Castro VT, Normando AGC, Prado-Ribeiro AC, Santos-Silva AR, Vargas-Ferreira F, Guerra ENS
Braz Oral Res · 2025 · PMID 40767661 · Full text
This cross-sectional study aims to investigate the prevalence of oral manifestations in a sample of the Brazilian population with COVID-19. Adults diagnosed with COVID-19 through real-time PCR/serological tests were invi...
This cross-sectional study aims to investigate the prevalence of oral manifestations in a sample of the Brazilian population with COVID-19. Adults diagnosed with COVID-19 through real-time PCR/serological tests were invited to participate. The online questionnaires were distributed at different times to analyze and compare SARS-CoV-2 variants considering the period of prevalence of these variants in Brazil. A total of 846 participants were included, of whom 539 were diagnosed before the Omicron variant. In total, 47.28% were vaccinated with at least two doses. The prevalence of oral manifestations was 52.6% (95%CI: 49.23-55.95), and the most common manifestations included taste disorder (38.06%; 95%CI: 34.85-41.38), xerostomia (17.61%; 95%CI: 15.19-20.32), and halitosis (11.58%; 95%CI: 9.59-13.92). The prevalence of persistent symptoms in post-COVID-19 was 12.1% (95%CI: 10.0-14.4) for taste disorder and 5.4% (95%CI: 4.1-7.1) for xerostomia. A significant association was found between females and persistent taste disorder (p = 0.0084) and oral manifestation and depression/anxiety (OR = 1.855, 95%CI: 1.267-2.717, p = 0.002), worse oral hygiene (OR = 1.729, 95%CI: 1.189-2.516, p = 0.004), and medication use (OR = 1.630, 95%CI: 1.123-2.367, p = 0.010) (p < 0.0001). In the Alpha, Beta, Gamma, and Delta variants, compared with the Omicron variant, taste disorder and xerostomia were less present when toothbrushing habits remained unchanged or improved (p < 0.0001). Oral manifestations in patients with COVID-19 were associated with depression/anxiety, worse oral hygiene, and medication, all of which reinforce its multifactorial etiopathogenesis.
Production and characterization of feldspathic-muscovite glass composite for dental prosthesis.
Pietoso FPFC, Santos SF, Silva LHD … +1 more , Cesar PF
Braz Oral Res · 2025 · PMID 40767660 · Full text
The principal objective of this studywas to produce and characterize a machinable glass ceramic containing muscovite-mica as the main crystalline phase to be used as a dental restorative material. The secondary objective...
The principal objective of this studywas to produce and characterize a machinable glass ceramic containing muscovite-mica as the main crystalline phase to be used as a dental restorative material. The secondary objective was to evaluate the use of muscovite-mica to improve machinability and generate a toughening mechanism in the experimental glass ceramic. After fine milling of a feldspathic glass frit was milled and then mixed with muscovite-mica, die-pressed, and sintered under vacuum at 850 to 1,150 °C. The resulting sintered composite was characterized by X-ray diffraction, scanning electron microscopy, and had its fracture toughness evaluated by micro-indentation. The results were as follows: (a) improved thermal stability of muscovite-mica crystals in the composite; (b) improved leucite crystallization in the feldspathic glass matrix by increasing sintering temperature in the studied range ; (c) the composites consisting of glass + 10% muscovite and glass + 20% muscovite sintered at 1,050°C presented fracture toughness values of 9.0 ± 1.2 and 8.4 ± 0.6 MPa.m1/2, respectively, which are higher than those found in the literature for glass ceramics. Feldspar frit blocks with addition of muscovite-mica (up to 20%) can be densified at temperatures between 1,050 and 1,150°C. This material was stable at a temperature substantially higher than the stability limit of pure muscovite and also showed indentation fracture toughness values greater than those reported in the literature for other glass ceramics.
Clinical evaluation of the effect of 980 nm diode laser and fluoride varnish on dentin hypersensitivity.
Ishikiriama SK, Moreira BN, Wang L … +3 more , Bombonatti JFS, Zabeu GS, Rizzante FAP
Braz Oral Res · 2025 · PMID 40638425 · Full text
Dentin hypersensitivity (DH) is a common and challenging clinical condition with limited long-lasting treatments. The objective of this study was to evaluate the effectiveness of 980 nm diode laser treatment, associated...
Dentin hypersensitivity (DH) is a common and challenging clinical condition with limited long-lasting treatments. The objective of this study was to evaluate the effectiveness of 980 nm diode laser treatment, associated or not with fluoride varnish, in the treatment of DH. Sixty volunteers were selected and randomly assigned for treatment following three different protocols (1- treatment with 0.8W diode laser; 2- treatment with 0.8 W diode laser over fluoride varnish; or 3- fluoride varnish only). The 0.8 W diode laser was applied in contact with the exposed roots at 10 Hz, for 30 s, with 99.17J/cm2 energy density, using a zigzag pattern. DH assessment was performed using the visual analog scale (VAS), prior to treatment, immediately after treatment, and at 7, 30, and 180 days after treatment. The data obtained were subjected to two-way repeated-measures analysis of variance (ANOVA) (p <0.05). The varnish group showed a reduction in DH up to 30 days, whereas the laser and laser + varnish groups showed a reduction in DH up to 180 days ,with no difference between them. The laser and laser + varnish groups were superior to the varnish group after 30 days. The treatment of exposed roots with diode laser alone or associated with fluoride varnish, according to the parameters used in this study, was effective in reducing DH up to six months.
Physicochemical and antibiofilm properties of new ready-to-use and powder/gel bioceramic endodontic sealers.
Pradelli JA, Jampani JLA, Santos-Junior AO … +2 more , Tanomaru-Filho M, Guerreiro-Tanomaru JM
Braz Oral Res · 2025 · PMID 40638424 · Full text
NeoSealer Flo (NSF) is a novel ready-to-use endodontic bioceramic sealer, and NeoMTA2 (NMTA2) is a powder-gel bioceramic used as a repair or filling material. Setting time (ST), pH, solubility, radiopacity, and flow were...
NeoSealer Flo (NSF) is a novel ready-to-use endodontic bioceramic sealer, and NeoMTA2 (NMTA2) is a powder-gel bioceramic used as a repair or filling material. Setting time (ST), pH, solubility, radiopacity, and flow were evaluated in accordance with the ISO 6876:2012 standards for NSF and NMTA2, in comparison with Bio-C Sealer (BCS) and AH Plus Jet (AHP). Bond strength was assessed using the push-out test. Antibiofilm activity was evaluated by a modified direct contact test on Enterococcus faecalis biofilm with fresh sealer eluate and material after setting. Data were analyzed using the t-test, ANOVA, and Tukey post-hoc tests (α = 0.05). AHP exhibited the highest ST value, followed by NMTA2 (p < 0.05). NSF and BCS showed solubility above 3%, while NMTA2 exhibited values lower than 3% (p < 0.05). All materials demonstrated radiopacity above 3 mm Al (p > 0.05). NMTA2 demonstrated flow below ISO-recommendation (p < 0.05). NSF showed the highest bond strength values (p < 0.05). The bioceramic sealers induced higher pH compared with AHP (p < 0.05). NMTA2 exhibited more significant antibiofilm activity after the sealer set (p < 0.05). For fresh sealer eluate, NSF, BCS, and AHP demonstrated higher levels of antibiofilm activity compared with NMTA2 (p < 0.05). NSF and NMTA2 demonstrated the required physicochemical and mechanical properties, as well as antibiofilm activity against E. faecalis. However, NSF and BCS presented higher solubility. NMTA2 presented adequate solubility, however lower flow rates than those recommended by ISO standards.
Associations between enamel defects and caries in patients with Down syndrome compared with normotypic patients.
Cruz PEA, Lavôr JR, Costa SGA … +3 more , Leão MAVC, Santos TGFTD, Rosenblatt A
Braz Oral Res · 2025 · PMID 40638423 · Full text
This study aimed to explore the prevalence of developmental defects of enamel (DDE) and dental caries in children with and without Down syndrome (DS) and evaluate potential associations between these conditions. This was...
This study aimed to explore the prevalence of developmental defects of enamel (DDE) and dental caries in children with and without Down syndrome (DS) and evaluate potential associations between these conditions. This was a cross-sectional, exploratory, census-based study with children of both sexes aged 6 to 11 years. The sample consisted of 10 children diagnosed with DS and 61 without DS. Standardized forms and records of dmft/DMFT and modified developmental defects of enamel (mDDE) were used. Inter- and intraexaminer agreement was assessed, with an intraclass correlation coefficient (ICC) of 0.93 for DDE and 0.81 for caries. The data were tabulated using SPSS 20.0. Categorical variables were subjected to Pearson's chi-square test to identify significant associations (p = 0.05). The Kolmogorov-Smirnov test revealed a nonnormal distribution pattern of the data (p <0.001). Therefore, numerical variables were subjected to the Mann-Whitney test to verify statistically significant differences (p = 0.05). Among the 71 study participants, 43 (60.6%) were male, and 28 (39.4%) were female. Among them, 10 (14.1%) had DS, 42 (59.2%) had caries, and 19 (26.8%) had DDE, with demarcated opacity as the most common type of DDE. A significant association was identified between having DS and not having dental caries (p = 0.007) and between having DS and having DDE (p <0.001). Individuals with DS were found to have 9.8 times greater odds of having DDE (p = 0.018). Compared with normotypic children, children with DS had a greater prevalence of DDE and a lower prevalence of dental caries. Additionally, children without DS were more likely to have caries in the presence of DDE.
Influence of luting space settings and polymerization-induced cement shrinkage and deformation/adaptation of CAD/CAM crowns.
Pereira LM, Melo BI, Bicalho AA … +4 more , Pereira RR, Prudente MS, Soares CJ, Neves FDD
Braz Oral Res · 2025 · PMID 40638422 · Full text
This study aimed to evaluate the adaptation of CAD/CAM crowns and the impact of resin cement polymerization contraction on crown deformation under different cementation configurations. Thirty human molars were randomly d...
This study aimed to evaluate the adaptation of CAD/CAM crowns and the impact of resin cement polymerization contraction on crown deformation under different cementation configurations. Thirty human molars were randomly divided into three groups (n = 10) to manufacture ceramic crowns with three different cementation space configurations: LD40 (40 μm), LD80 (80 μm), and LD160 (160 μm). The samples were subjected to computerized microtomography scanning for measuring internal and marginal adaptation, and internal fit was analyzed at occlusal, axial, axiogingival points. Five light-curing protocols were used to verify the wavelength spectrum peak of the curing device and the irradiance delivered using two situations: with 0 mm sensor distance and through a ceramic of differing thickness, and an external crown deformation (ECD) test. The highest statistically significant vertical fit was obtained for group LD40, independent of region. LD160 yielded the highest ECD values, independent of positioning of the buccal and distal strain gauge. The highest internal fit was observed at occlusal and axial points of the LD160 group (P<0.001), and LD80 yielded the lowest values at the axiogingival point (p = 0.003, p = 0.006). The irradiance delivered was reduced significantly upon interposition of the ceramic block to the sensor. The peak wavelength for curing was similar among the LD groups. The luting space configurations significantly influenced vertical fit and the ECD results for the CAD/CAM ceramics owing to polymerization shrinkage. Finally, variations in ceramic thickness at different sites affected both the irradiance by the curing device and ECD results.
Bleaching at acidic and basic pH for enamel and dentin whitening using internal and external techniques.
Paini TRD, Souza M, Castro-Hoshino LV … +7 more , Previdelli ITS, Bento AC, Sato F, Tsuzuki F, Terada RSS, Baesso ML, Pascotto RC
Braz Oral Res · 2025 · PMID 40638421 · Full text
This study aims to evaluate in vitro the whitening effects of gels containing hydrogen peroxide at acidic and basic pH using internal and external techniques. Forty artificially darkened bovine incisors were split into f...
This study aims to evaluate in vitro the whitening effects of gels containing hydrogen peroxide at acidic and basic pH using internal and external techniques. Forty artificially darkened bovine incisors were split into four groups: bleaching on the buccal surface with HPE (HP Blue 35%, FGM), at basic pH; PBE (Potenza Bianco 38%, PHS), at acidic pH; bleaching in the pulp chamber with HPI at basic pH; and with PBI at acidic pH. CIELab color parameters, microhardness, roughness, enamel demineralization (FT-Raman), and surface topography (SEM) were evaluated in enamel/dentin blocks after bleaching (T0) and seven days after immersion in saliva (T7). Bleaching agent diffusion was evaluated after 30 minutes, while pH was measured throughout the application period. Physicochemical analysis showed a reduction in the mineral-matrix ratio in both groups after bleaching and at 7 days. Roughness increased over time in the PBE and HPE groups. Porosity increased, but decreased after 7 days of immersion in saliva. Bleaching gels were different at T0 and T7, with acidic pH gel promoting greater whitening (T7) and enamel roughness. Raman scanning demonstrated that the bleaches propagated across the enamel layer with increased concentration at the dentin-enamel-junction and decreasing diffusion gradient along the dentin. The gel with acidic pH promoted a greater increase in enamel roughness and the 7-day immersion in saliva was not enough to restore initial roughness in either gel. The gel with basic pH showed a higher pH decay and a greater diffusion capacity in the dentin.
Tropical almond antioxidant gels mitigate the adverse effects of strong whitening agents on immediate bonding.
Mejía VC, Marques VM, Araújo TG … +5 more , Moura LC, Fiallos ACM, Melo MAS, Santiago SL, Passos VF
Braz Oral Res · 2025 · PMID 40638420 · Full text
Radicals from tooth whitening products can reduce bond strength, posing challenges for dentists when a bonding procedure must be performed in teeth immediately after whitening. This study aimed to evaluate the antioxidan...
Radicals from tooth whitening products can reduce bond strength, posing challenges for dentists when a bonding procedure must be performed in teeth immediately after whitening. This study aimed to evaluate the antioxidant activity (AA) of Terminalia catappa Linn (TCL) leaf extract as a potential agent to mitigate the negative impact of high-concentration whitening agents on immediate bonding performance. The AA of green and ripe leaf extracts was measured using the 2,2-di-phenyl-1-picrylhydrazyl radical scavenging capacity assay (DPPH). To determine the TCL influence on bond strength, six groups of bovine enamel blocks (n=10) were created. Group 1 was the positive control (unbleached enamel), while Group 2 was the negative control (no antioxidant treatment). Groups 3 to 6 were bleached and treated with 10% sodium ascorbate (SA) or 0.1%, 0.2%, and 0.3% TCL gels. Adhesion was conducted using a two-step conventional system and dental composite resin. Microtensile testing was performed after 24 hours, and data were analyzed by one-way ANOVA with Tukey's post hoc test (p > 0.05). From the DPPH assay, results with IC50 < 50 µg/mL indicate high AA for all tested extracts. This method established a difference of around 12 times more AA for the TCL-hydroalcoholic extract of green leaf to the aqueous extract of ripe leaves. There were no significant differences in bond strength among groups treated with TCL-hydroalcoholic extract of green leaf gels (p > 0.05) and unbleached enamel. Tropical almond-derived antioxidant gels emerge as a promising strategy to enhance immediate bond strength on enamel after high-concentration in-office whitening treatments.
The role of citric acid in denture cleansing: Effects on biofilm reduction and corrosion resistance of Co-Cr alloys.
Borges MHR, Miranda LFB, Malheiros SS … +6 more , Silva AG, Calazans Neto JV, Santos MAD, Rangel EC, Barão VAR, Nagay BE
Braz Oral Res · 2025 · PMID 40638419 · Full text
This in vitro study evaluated the effects of citric acid (CA) on surface properties, biofilm removal, and electrochemical performance of Co-Cr alloys compared to common denture cleansers. Co-Cr discs were divided into fi...
This in vitro study evaluated the effects of citric acid (CA) on surface properties, biofilm removal, and electrochemical performance of Co-Cr alloys compared to common denture cleansers. Co-Cr discs were divided into five groups based on the decontamination solution: NaCl 0.9% (control), Corega Tabs®, Periogard®, and 10% CA. The surface was characterized at baseline in terms of morphology, topography, and chemical and phase composition. Surface properties, including microhardness, wettability, and roughness, were assessed before and after exposure to each solution. Microbial viability, metabolic activity, and morphology of the polymicrobial biofilm were assessed after treatment to evaluate the efficacy of the decontamination solutions. Electrochemical and morphological evaluations were performed to assess the impact of each solution on the alloy's corrosion process. No significant changes in microhardness were observed (p > 0.05). Decontamination solutions significantly increased surface hydrophilicity (p < 0.05) and roughness, though Ra values remained below the threshold for bacterial colonization. All denture cleansers significantly reduced biofilm viability compared to NaCl (p < 0.05), with no viable colonies post-treatment. The CA group showed a significant reduction in bacterial metabolic activity compared to NaCl and Periogard® (p < 0.05), indicating superior biofilm disruption. Electrochemical tests demonstrated that CA maintained a stable Cr-oxide passive layer, evidenced by nobler OCP values and lower icorr and corrosion rates compared to Periogard® (p < 0.05). SEM images revealed pitting corrosion in all groups, except CA. These findings suggest that CA is a promising and safer alternative for denture care, offering effective antimicrobial action while preserving the electrochemical integrity of Co-Cr alloys.
EDTA enhances cementum-like tissue formation, TGF-β1 & VEGF in rat molars during regenerative endodontics.
Reis-Prado AHD, Silva IJP, Goto J … +9 more , Machado NEDS, Avelar GF, Albergaria JDS, Szawka RE, Bottino MC, Cintra LTA, Ervolino E, Ribeiro-Sobrinho AP, Benetti F
Braz Oral Res · 2025 · PMID 40638418 · Full text
This study investigated the influence of ethylenediaminetetraacetic acid (EDTA) irrigation on cementum-like tissue formation and TGF-β1, FGF-2, and VEGF immunolabeling during regenerative endodontic procedures (REPs) in...
This study investigated the influence of ethylenediaminetetraacetic acid (EDTA) irrigation on cementum-like tissue formation and TGF-β1, FGF-2, and VEGF immunolabeling during regenerative endodontic procedures (REPs) in immature rat molars. The lower first molars of 12 four-week-old male rats (80 g) underwent pulpectomy in the mesial canal and were randomly categorized into two experimental groups (n = 6): sodium hypochlorite (NaOCl) - irrigated for 5 min with 2.5% NaOCl; and NaOCl-EDTA - irrigated with 2.5% NaOCl, followed by 5 min of 17% EDTA. After inducing bleeding with a size 10 K-file, the cavities were sealed. Untreated molars served as control-15d (n = 3) and immediate control (n = 3). Either immediately or after 15 days, the animals were euthanized, and the teeth were collected for histomorphometric and immunohistochemical (TGF-β1, FGF-2, and VEGF) analysis. The results were analyzed by the Mann-Whitney U-test (p < 0.05). Histomorphometric analysis revealed increased cementum-like tissue formation in the NaOCl-EDTA group compared with that in the NaOCl group (p < 0.05). Regarding growth factor immunolabeling, the NaOCl-EDTA group exhibited enhanced TGF-β1 and VEGF immunolabeling in the root tip area and the center region of the apical third of the pulp tissue, compared with that in the NaOCl group (p < 0.05); however, no significant difference was observed in FGF-2 (p > 0.05). In conclusion, the use of EDTA in REPs positively affected the formation of cementum-like tissue and TGF-β1 and VEGF in the apical region but did not influence FGF-2.
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