Moura RNV, Paiva SM, Ramos-Jorge J
… +5 more, Pinto RDS, Lara JVI, Barbosa MCF, Alonso LS, Drummond AMA
Braz Oral Res
· 2025 Apr · PMID 40396850
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This study investigated the social inequities related to dental caries, clinical consequences of untreated caries, and the urgency to treat five-year-old children in Brazil. It is a cross-sectional study that used data f...This study investigated the social inequities related to dental caries, clinical consequences of untreated caries, and the urgency to treat five-year-old children in Brazil. It is a cross-sectional study that used data from SB Brasil 2023 (n = 7198). The dmft index was used to assess dental caries, the pufa index to assess the pulp consequences of untreated caries lesions, and the need for treatment was identified. It included demographic and context variables: sex, color/race, enrollment in social programs, access to water in the household, and use of dental services. Logistic regression models for complex samples were used to estimate gross and adjusted odds ratio (OR), and confidence intervals (95%CI). The prevalence of early childhood caries (ECC) was 46.83%, with an average of 2.14 affected teeth, and 41.18% had untreated caries lesions. Non-white children and those enrolled in social programs had higher chances of having dental caries. The clinical consequences were associated with non-white children and with the last use of dental services being more than 3 years ago. Mothers with higher levels of education and the presence of piped water in the household were protective factors. This study highlights the high prevalence and inequities related to ECC in Brazil. Non-white children, beneficiaries of social programs, and those with limited use of dental services were more vulnerable to caries, its clinical consequences, and the urgency of immediate treatment. These results reinforce the importance of public policies to reduce inequalities and expand access to preventive dental care.
Ferreira RC, Pinto RDS, Reis CD
… +5 more, Moura RNV, Aguiar SO, Drummond AMA, Gomes VE, Martins AMEBL
Braz Oral Res
· 2025 Apr · PMID 40396849
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This methodological study presents the development and implementation of technological tools for the online training and calibration of dentists participating in the SB Brasil 2023 survey, using the Moodle® platform. The...This methodological study presents the development and implementation of technological tools for the online training and calibration of dentists participating in the SB Brasil 2023 survey, using the Moodle® platform. The training and in-lux calibration process employed 10 and 25 sets of photographs, respectively. Conditions including dental crown status (dmft and DMFT indexes), caries consequences (pufa/PUFA index), malocclusion (canine relation, overjet, overbite, posterior crossbite, and Dental Aesthetic Index), and dental trauma were evaluated, based on WHO or SB Brasil 2010 criteria. Software was developed to record codes, automated calculations of agreement coefficients (overall percentage, score-specific, and simple and weighted kappa), and generate reports. Examiners were allowed to repeat calibration attempts until they achieved a minimum agreement (Kappa ≥ 0.61). In total, 1,513 examiners used the software, and 728 successfully completed the calibration with substantial or higher agreement across all conditions/indexes. Individual reports described discrepancies and monitored attempts. Occlusal conditions had the lowest percentages of almost perfect agreement and required more attempts to achieve calibration. The technological tools implemented in SB Brasil 2023 enabled online training and calibration, promoting consistency among examiners for fieldwork. These findings demonstrate the feasibility of remote strategies for calibration in epidemiological surveys, particularly in scenarios involving multiple geographically distributed examiners, with potential applications in other contexts and health areas.
Braz Oral Res
· 2025 Apr · PMID 40396848
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The oral health surveys conducted in Brazil since the 1980s, aligned with the guidelines of the National Oral Health Policy, have been essential for epidemiological surveillance. Over the surveys, variations in the appli...The oral health surveys conducted in Brazil since the 1980s, aligned with the guidelines of the National Oral Health Policy, have been essential for epidemiological surveillance. Over the surveys, variations in the applied sampling plans have occurred, including changes in the study domains. In SB Brasil 2023, an effort was made to meet the demands of state managers by expanding the domains including Federative Units and capitals. This study presents the sampling plan and assesses the precision of dmft and DMFT estimates for the defined domains. The sampling process was stratified (capitals and interior of the Federative Units) and involved a two-stage cluster design (census tract and households) for the age groups 15-19, 35-44, and 65-74 years, while a single-stage design was used for the ages of 5 and 12 years. The planned sample size was 250 (for ages 5 and 12) or 300 (for the other age groups) in the capitals, with an additional 100 interviews in the interior to obtain estimates for the Federative Units. The number of census tracts in each stratum was determined to achieve 250 interviews for the ages of 5 or 12 years. During the data analysis phase, base weights were adjusted through post-stratification based on sex, age, and education level, using data from the 2022 Continuous National Household Sample Survey, aiming to minimize selection and response biases. The dmft and DMFT estimates were evaluated using the coefficient of variation. Most estimates were precise, both for the capitals and for the Federative Units, with greater precision in the capitals.
Braz Oral Res
· 2025 Apr · PMID 40396847
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This study analyzes the methodological aspects of the SB Brasil epidemiological surveys conducted in 2003, 2010, and 2023. The sample plan, fieldwork, sampling process, investigated variables, and operational aspects wer...This study analyzes the methodological aspects of the SB Brasil epidemiological surveys conducted in 2003, 2010, and 2023. The sample plan, fieldwork, sampling process, investigated variables, and operational aspects were examined based on technical documents and relevant publications. All three surveys adopted complex, probabilistic cluster sampling, with different study domains and sample sizes across editions. Data collection was conducted by SUS workers in all three editions, and Community Health Agents (ACS) were included as data collector in 2023. In this edition, the listing process occurred in a separate phase before the interview and examination, in two stages, to update the address list and identify eligible residents. Data collection included oral examinations and household interviews. The health conditions and oral health indices, as well as the criteria for defining the assessed conditions for each age group, remained similar across surveys. SB Brasil 2023 introduced, for the first time, the evaluation of the clinical consequences of untreated dental caries and the intervention urgency. There was an expansion of demographic and socioeconomic variables and subjective aspects of oral health over the editions. Increasing incorporation of technologies for data recording was observed, with automation of the sample selection process and report generation to support fieldwork monitoring. These changes reflect a continuous commitment to producing high-quality data, essential for supporting public policies and strengthening oral health surveillance in Brazil.
Oral squamous cell carcinoma (OSCC) remains the most prevalent neoplasm of the head and neck. In recent decades, the incidence and prevalence of OSCC have not significantly changed, highlighting the critical need to deve...Oral squamous cell carcinoma (OSCC) remains the most prevalent neoplasm of the head and neck. In recent decades, the incidence and prevalence of OSCC have not significantly changed, highlighting the critical need to develop and implement new risk assessment measures. The present study aimed to define argyrophilic proteins of the nucleolar organizer region (AgNOR) cut-off risk points by oral exfoliative cytological smears comparing specialized humans with a convolutional neural network (CNN) system AgNOR Slide-Image Examiner. This study included four experimental groups: control, exposure to carcinogens (alcohol and tobacco), oral potentially malignant disorders, and OSCC. In the first phase, 50 cells were used for AgNOR quantification. In the second phase, AgNOR quantification was established in an automated manner using an AgNOR System - Slide Examiner (captured - bounding-boxed - CNN analysis). In phase 1, the cut-off point for considering a smear as suspicious was established at 3.69 AgNORs/nucleus with sensitivity of 86%, specificity of 93%, and accuracy of 90%. In phase 2, the analysis of the intraclass correlation coefficient of AgNORs attributed to the system and human was 0.896 (95% confidence interval = 0.875-0.915; p < 0.0001), and this quantification with the CNN was 20 min compared to 67 h, considering human analysis. The AgNOR Slide-Image Examiner successfully differentiated the nuclei and accurately quantified the number of NORs in oral cytological smears. The cut-off risk point of 3.69 AgNOR/nucleus indicates a suspicious sample may contribute to improvements in oral cancer screening.
The aim of this study was to evaluate the association of body image perception and self-assessment of oral health with other associated factors in a sample of Brazilian adolescents. This cross-sectional study involved a...The aim of this study was to evaluate the association of body image perception and self-assessment of oral health with other associated factors in a sample of Brazilian adolescents. This cross-sectional study involved a total of 281 adolescents aged 14 to 19 years enrolled in 29 public schools from May 2021 to December 2023 in the urban area of Juiz de Fora, state of Minas Gerais, Brazil. The total enrollment of 9,502 participants in the first stage of the study () was considered for sample size calculation. The prevalence of negative self-assessment of oral health in the adolescent population was estimated at 18%, with a standard error of 1%, a 95% confidence interval, and a 20% loss to follow-up. Participants completed a questionnaire via the Google Forms platform, which gathered information on their socioeconomic status, self-perception of body image, self-assessment of oral health, and self-esteem. Bivariate analysis and logistic regression models were used to evaluate the associations between variables. Variables with p < 0.10 in the bivariate analysis were included in the logistic regression model. Variables with p < 0.05 were retained in the final model. The final logistic regression model revealed that adolescents with a higher socioeconomic status rated their oral health as excellent or good. Additionally, those who reported not living with their parents and had a low level of self-esteem had a poor oral health self-assessment. Adolescents' perception of their body image was not associated with oral health self-assessment. On the other hand, socioeconomic factors, family structure, and self-esteem influenced adolescents' oral health self-assessment.
This study aimed to investigate oral conditions and their impact on salivary biochemical parameters in institutionalized individuals with and without substance use disorder. This was an epidemiological, cross-sectional,...This study aimed to investigate oral conditions and their impact on salivary biochemical parameters in institutionalized individuals with and without substance use disorder. This was an epidemiological, cross-sectional, and clinical study. It included two groups, institutionalized individuals with substance use disorder (SUD group) and without substance use disorder (control group), each consisting of 60 participants. Salivary samples were analyzed for various parameters, while oral conditions were assessed using the DMFT index, community periodontal index, clinical attachment loss index, and need for prosthesis. Statistical analysis included the Mann-Whitney U test, t-tests, and correlation analysis (p ≤ 0.050). The SUD group showed a higher need for dental prostheses (p < 0.001) and more pronounced dental erosion (p < 0.001). This group also exhibited elevated DMFT indices, with significant associations in sextants with calculus (p = 0.010), periodontal pockets (p < 0.001), and attachment loss of 12 mm or more (p = 0.036). Regarding salivary parameters, the SUD group had high cortisol levels and significant correlations between uric acid and bleeding sextants (p = 0.024), salivary amylase and decayed teeth (p = 0.002), cortisol and the DMFT index (p = 0.045), and cortisol and the absence of DMFT (p = 0.042). In conclusion, individuals in the SUD group exhibited worse oral conditions than did those in the control group, suggesting a relationship between drug addiction and increased cortisol, uric acid, and salivary amylase levels.
The aim of this study was to verify the role of Brazilian researchers in publications related to photobiomodulation (PBM) in the field of oral medicine. We examined ten years from 2012 to 2022 across 16 journals. Our ana...The aim of this study was to verify the role of Brazilian researchers in publications related to photobiomodulation (PBM) in the field of oral medicine. We examined ten years from 2012 to 2022 across 16 journals. Our analysis included scientific publications with a Brazilian author either in the first or last position and publications from international collaborations. The search yielded 43,525 publications. After examining titles and abstracts, 269 studies were categorized as having a specific emphasis on PBM in oral medicine, of which 147 (54.6%) were undertaken by research groups based in Brazil. The citations ranged from 1 to 149 (an average of 31 per manuscript). The male-to-female ratio of first and last author was 1:2 and 1:1.4, respectively. Brazilian involvement in the field of PBM was significant, with a marked focus on basic research, clinical applications, and technological advances. Our results also underscore the remarkable participation of female researchers in pivotal roles. Brazilian publications positively impacted healthcare worldwide using PBM in oral medicine, as evidenced by the substantial number of articles published and the citations of these articles received.
In this study, citations, altmetric scores, and field-normalized impact of articles investigating resin-based adhesives, luting agents, or restorative composites were investigated. Articles published in 2019 on resin-bas...In this study, citations, altmetric scores, and field-normalized impact of articles investigating resin-based adhesives, luting agents, or restorative composites were investigated. Articles published in 2019 on resin-based dental materials indexed in Scopus were searched and assessed by independent investigators. Data collected in 2023 included several article variables and, as outcomes, citation in Scopus and Google Scholar, Altmetric Attention Scores (AAS), and Field-Weighted Citation Impact (FWCI). Data were analyzed using stepwise backward quasi-Poisson regression models (p < 0.05). A total of 707 articles were included, which evaluated restorative composites (58.3%), adhesives (27.2%), and luting agents (19.5%). The majority of corresponding authors were from Asia/Oceania (42.2%), with publications mainly subscription-based (54%) and lacking international collaboration (68.5%). Only 1.4% reported conflicts of interest, and 47.7% did not disclose sponsorship. Median citations were 7 in Scopus and 13 in Google Scholar, whereas the median FWCI was 1. The majority of articles had an AAS of zero. Multivariate analysis showed study sponsorship type and journal CiteScore influenced citations, while COI and the author's continent impacted AAS and FWCI, respectively. Articles on luting agents were less likely to receive citations. The report of conflict of interest was associated with approximately 18 times higher AAS values. This study emphasizes the significance of the type of resin-based material, journal CiteScore, authors' continent, and type of sponsorship in affecting citations, visibility, and impact of scientific articles. Research on luting agents may need better dissemination strategies for increased visibility. The substantial effect of COI presence underscores the importance of transparency.
The iVAC system combines ultrasonic activation with negative-pressure irrigation, highlighting the importance of determining its vibration characteristics. This study aimed to evaluate the oscillation characteristics of...The iVAC system combines ultrasonic activation with negative-pressure irrigation, highlighting the importance of determining its vibration characteristics. This study aimed to evaluate the oscillation characteristics of the iVAC system using laser Doppler vibrometry and to compare them with those of metallic inserts used for ultrasonic irrigation. Four ultrasonic inserts-Irrisonic, Nitisonic, Ultra X Blue, and iVAC-were attached to an ultrasonic unit, secured in a holder, and operated at a power setting of 15%. A laser scanning vibrometer was used to scan the first four millimeters of each insert. Each measurement, lasting approximately 20 seconds, was repeated ten times per insert and performed at millimeter intervals. Displacement amplitude and frequency data were recorded for each insert. Furthermore, scanning electron microscopy was employed to evaluate the surface finish of the inserts, and their elemental compositions were analyzed using energy-dispersive X-ray spectroscopy (EDS). Analysis of variance and Tukey's test were conducted to compare the performance of the inserts. The displacement amplitudes showed significant differences between inserts and among the scanned points (p < 0.05). All inserts demonstrated ultrasonic vibration frequencies exceeding 20 kHz. EDS analysis revealed that the elemental composition of the E1-Irrisonic tips was consistent with stainless steel. In contrast, the Nitisonic insert displayed a chemical composition characteristic of an equiatomic nickel-titanium (NiTi) alloy, whereas the Ultra X Blue insert contained additional elements beyond NiTi. The characteristics and composition of ultrasonic inserts significantly influence their displacement amplitude and vibration frequency. At the tested activation power, the iVAC insert, made of the organic thermoplastic polymer polyether ether ketone (PEEK), demonstrated an ultrasonic vibration pattern but exhibited the lowest oscillation amplitude among the inserts.
Preventive maintenance in pediatric dentistry is essential for monitoring oral health and promoting healthy habits. This study aimed to evaluate how the frequency of follow-up appointments, as well as sex- and age-relate...Preventive maintenance in pediatric dentistry is essential for monitoring oral health and promoting healthy habits. This study aimed to evaluate how the frequency of follow-up appointments, as well as sex- and age-related differences, impact the probability of referral for curative treatment among pediatric dentistry patients at a Brazilian dental school. This retrospective longitudinal study included dental records of patients who had their first appointment between the second half of 2013 and the second half of 2019, completed treatment, and returned for at least one check-up visit. Descriptive and survival analyses were performed. A total of 296 dental records were evaluated, comprising 47.6% female and 52.4% male patients. The likelihood of referral to curative treatment increased with longer follow-up intervals, reaching 18.9% at six months and 82.7% at 48 months. Patients aged 9 years or younger were 2.07 times more likely to be referred to curative treatment than those aged 10 years or older. No significant difference was observed in referral probability between boys and girls. Longer intervals between check-up visits increased the likelihood of referral to curative treatment, which was higher among older children. Establishing personalized follow-up intervals based on individual patient needs is crucial for maintaining oral health.
Data were collected by trained interviewers at primary healthcare units and hospitals during pregnancy and childbirth, and by trained dentists when the children were 4 years old. A total of 3,644 mothers and 3,645 babies...Data were collected by trained interviewers at primary healthcare units and hospitals during pregnancy and childbirth, and by trained dentists when the children were 4 years old. A total of 3,644 mothers and 3,645 babies were included in the study, which evaluated the association between systemic diseases, maternal physical activity, weight gain during pregnancy, and the oral health of four-year-old children enrolled in the 2015 Pelotas Birth Cohort (Brazil). Exposure variables included systemic diseases, maternal physical activity, and gestational weight gain. Outcome variables were dental caries and caries experience in four-year-old children, assessed using the ICDAS index. Statistical analyses were performed using the Stata 15 software, and they included Pearson's chi-square test and Poisson regression to estimate prevalence ratios and their respective 95% confidence intervals. Excessive weight gain during pregnancy was associated with a higher risk of dental caries in children (PR: 1.12; 95%CI: 1.01-1.23). Maternal physical activity before or during pregnancy was considered a protective effect against dental caries in the unadjusted analysis ([RP: 0.82; 95%CI: 0.71-0.93] [RP: 0.60; 95%CI 0.44-0.81]), respectively, but this association was no longer significant after adjusting for confounding factors. The presence of maternal systemic diseases during pregnancy was not associated with childhood caries. In conclusion, maternal systemic diseases during pregnancy were not associated with dental caries in children. On the other hand, an excessive increase in maternal weight during pregnancy was associated with poorer oral health among children.
Objectively evaluating an individual's capacity for food fragmentation (masticatory performance) is crucial for understanding oral physiology and dental rehabilitation processes. Our aim was to conduct a bibliometric ana...Objectively evaluating an individual's capacity for food fragmentation (masticatory performance) is crucial for understanding oral physiology and dental rehabilitation processes. Our aim was to conduct a bibliometric analysis of the literature focusing on masticatory performance. We conducted a survey in Web of Science up to August 31, 2024, applying specific category filters. Two calibrated reviewers manually tabulated the data, extracting information on title, authorship, keywords, institutions, countries, number of citations, year of publication, journal title, study design, masticatory test, population, and dentition status. VosViewer software generated collaborative network maps, while JAMOVI was used to perform ANOVA and Poisson regression analyses. The selection process resulted in 814 articles published between 1950 and 2024, with a recent increase to at least 50 articles per year. The average impact factor was 3.16, with around 30 citations per article. Citations were significantly influenced by the masticatory performance technique, publication year, and journal impact factor. The comminution test was the most prevalent (n = 411). Most studies focused on adults (n = 420) and older adults (n = 361), in which natural dentition (n = 404) and complete dentures (n = 214) were the most widely assessed parameters. The most frequent study designs were cross-sectional (n=489) and prospective (n = 145). The leading countries were Japan (n=202), Brazil (n=134), and the Netherlands (n = 69), and the Journal of Oral Rehabilitation was the most recurrent journal (n = 162). This study highlights the growing interest in evaluating masticatory performance, with a significant increase in publications over the years. This study highlights the need for further research involving children and longitudinal study designs, as well as studies evaluating rehabilitations with removable partial denture and implant-supported prostheses.
This study aimed to establish the frequency of oral mucosal conditions and xerostomia, identify a possible association between them, and verify their associated factors from a sample of the population of Três Corações, B...This study aimed to establish the frequency of oral mucosal conditions and xerostomia, identify a possible association between them, and verify their associated factors from a sample of the population of Três Corações, Brazil. A cross-sectional study was conducted with volunteers without age restriction. To evaluate the presence of oral mucosal conditions, an intra-oral examination was performed and a clinical diagnosis was established based on the official classifications of oral diseases. The report of xerostomia was identified by a validated questionnaire completed during anamnesis. Descriptive and association statistics were performed using a significance level of 5%. A total of 1,052 volunteers were evaluated. Oral mucosal lesions were observed in 42.11%, variations of normal structures in 38.50%, and xerostomia in 60.64%. Women were more affected than men, particularly women aged 20-49. Xerostomia was not found to be associated to oral mucosal conditions in general (p > 0.05); however, inflammatory fibrous hyperplasia (27.99%) and oral candidiasis (24.38%), the most prevalent lesions in the study, were associated with xerostomia (p < 0.001 and p = 0.006, respectively) and denture use (p = 0.025 and p < 0.001, respectively). Use of tobacco and alcohol intake were not associated with the presence of oral lesions (p = 0.319 and p = 0.739, respectively). The findings of this study are important for determining the prevalence of oral conditions and xerostomia in the general population, serving as a baseline for further investigations into the association between xerostomia, inflammatory fibrous hyperplasia, and oral candidiasis.
The objective of this study was to estimate the prevalence of comorbidities among people living with HIV/AIDS (PLWHIV) attending a dental outpatient clinic and discuss the impact of these comorbidities on dental manageme...The objective of this study was to estimate the prevalence of comorbidities among people living with HIV/AIDS (PLWHIV) attending a dental outpatient clinic and discuss the impact of these comorbidities on dental management. A cross-sectional observational study evaluated 238 PLWHIV attending a specialized dental outpatient clinic in Brazil. We collected sociodemographic data, self-reported and physician-diagnosed comorbidities, hemogram results, CD4+ T cell count, viral load, use of combined antiretroviral therapy (cART), and information on harmful habits. The most prevalent comorbidities were sexually transmitted infections (STIs) (116/238; 48.7%), psychiatric disorders (105/238; 44.1%), and lipodystrophy (97/238; 40.8%). Men were more likely to have STIs (OR 4.0) and tuberculosis (OR: 2.5) (p < 0.05). Age ≥ 50 years increased the risk of diabetes mellitus by 2.6 times (p < 0.05). The risk of lipodystrophy (OR: 2.99, 95%CI 1.44-6.19) and psychiatric disorders (OR: 2.13, 95%CI 1.01-4.47) was greater in those who had been diagnosed with HIV for more than 20 years. In summary, psychiatric disorders and severe hematological alterations, such as anemia and neutropenia, are significant comorbidities that may limit dental treatment of HIV-positive patients. These findings underscore the need for integrated medical and dental care to address the complex health needs of PLWHIV.
Ultrasonic activation of the endodontic sealer makes it difficult to remove the material during endodontic reintervention. Therefore, supplementary removal protocols should be tested to optimize the removal of the remain...Ultrasonic activation of the endodontic sealer makes it difficult to remove the material during endodontic reintervention. Therefore, supplementary removal protocols should be tested to optimize the removal of the remaining filling material. This study assessed the effectiveness of supplementary protocols for filling material removal after sealer ultrasonic activation (UA). Sixty teeth were prepared and distributed into two groups: UA and No UA of the sealer before obturation. Teeth were re-instrumented and two supplementary removal protocols were tested, resulting in six groups (n = 10): NoUA; NoUA+XP (XP-endo Finisher); NoUA+CS (Clearsonic-R1); UA; UA+XP; and UA+CS. Root canals were analyzed under stereomicroscopy and scanning electron microscopy for quantification of the remaining filling material. Considering the total root canal area, the NoUA+CS group had the lowest remaining filling material compared to NoUA+XP, UA+XP and UA+CS groups (p < 0.05). When the root thirds were compared, there was no statistical difference among groups (p > 0.05). The XP-endo Finisher instrument demonstrated the lowest effectiveness when used as a supplementary step. In contrast, the Clearsonic-R1 insert exhibited the highest performance.
The aim was to evaluate the association between dental development (dental maturity) and genetic polymorphisms in PTH and genes involved in vitamin D synthesis in a cohort of Brazilian children. This retrospective cross-...The aim was to evaluate the association between dental development (dental maturity) and genetic polymorphisms in PTH and genes involved in vitamin D synthesis in a cohort of Brazilian children. This retrospective cross-sectional study was performed on children receiving orthodontic treatment. Patients who had already undergone orthodontic treatment previously, those with syndromes, congenital anomalies, craniofacial deformities, and those with a previous history of dental trauma and bilateral agenesis/missing tooth/teeth were excluded. Panoramic radiographs were used for dental age evaluation according to the method proposed by Demirjian, Goldstein, and Tanner (1976). A delta [dental age minus chronological age (DA-CA)] was calculated to determine whether the patient's dental age was normal, delayed (negative values), or advanced (positive values). DNA isolated from buccal cells was used for genotyping genetic polymorphisms in PTH (rs694, rs307247, and rs6256), VDR (rs7975232), CYP27B1 (rs464653), and CYP24A1 (rs927650). A statistical analysis was performed and p<0.05 indicated statistical difference. A total of 79 orthodontic patients were included (44 (55.70%) girls and 35 (44.30%) boys). Demirjian, Goldstein, and Tanner's method (1976) overestimated the age of patients by 0.75 years. None of the genetic polymorphisms were associated with dental age (p>0.05). In conclusion, there is no association between genetic polymorphisms in PTH and genes involved in vitamin D synthesis and dental maturity.