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Braz Oral Res [JOURNAL]

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Oral adverse effects of head and neck radiotherapy with/without chemotherapy in a southern Brazil hospital.

Schorr JL, Almeida Loureiro FJ, Frenzel Schuch L … +5 more , Petersen Wagner V, Carrard VC, Neves M, Martins MAT, Martins MD

Braz Oral Res · 2025 · PMID 40172434 · Full text

The aim of this study was to evaluate the main oral adverse effects and their relationship with dental care before radiotherapy (RT) and combined RT and chemotherapy (RT+CT). Additionally, we assessed the association of... The aim of this study was to evaluate the main oral adverse effects and their relationship with dental care before radiotherapy (RT) and combined RT and chemotherapy (RT+CT). Additionally, we assessed the association of other risk factors with the development of these adverse effects. This paper is a retrospective cross-sectional analytical study of data from medical records of patients with head and neck cancer (HNC) who underwent RT or RT+CT attended at the stomatology unit in a southern Brazil hospital. The records of 78 patients with HNC were accessed. Demographic data, tumor characteristics, cancer treatment, follow-up data, adverse effects, and dental treatment prior to RT were evaluated individually for descriptive analysis. Kaplan-Meier survival curves were plotted. Risk factors were assessed using chi-square or Mann-Whitney test. The results showed that most patients were male (88.3%) in their 6th decade of life. Tumors were mostly located in the oral cavity (52.6%) and squamous cell carcinoma was the main diagnosis (94.8%). Most cases were diagnosed in advanced stages (67.9%). RT was of 2D or 3D types in 93.6% of patients. Oral adverse effects were observed in 94.7% of patients treated with RT or RT+CT. Osteoradionecrosis (ORN), oral mucositis (OM), candidiasis, and xerostomia were the main complications. Patients who received 2D RT had higher risk of developing ORN and xerostomia compared to those who received 3D RT. The risk of developing ORN was higher in smokers compared to non-smokers and in patients who had not previously consulted a dentist. This study showed that patients who underwent RT for HNC have a high occurrence of oral complications. Dentists play a key role in the management of these oral side effects.

Educational strategies on tooth avulsion for teachers: an intervention study.

Fochi TC, Tuchtenhagen S, Taufer JC … +1 more , Ortiz FR

Braz Oral Res · 2025 · PMID 40105520 · Full text

Tooth avulsion is an emergency dentoalveolar trauma, and knowledge of this condition can improve the prognosis of trauma. This study aimed to assess and improve elementary school teachers' knowledge of tooth avulsion usi... Tooth avulsion is an emergency dentoalveolar trauma, and knowledge of this condition can improve the prognosis of trauma. This study aimed to assess and improve elementary school teachers' knowledge of tooth avulsion using two educational intervention methods. Data were obtained through a parallel, blinded educational intervention study involving 116 teachers from public and private schools. They participated and completed a structured questionnaire regarding the immediate measures required for dentoalveolar trauma to permanent teeth, storage methods, and the ideal time for the dental element to remain outside the socket. After randomly assigning teachers to the leaflet and video groups, they were provided guidance on dentoalveolar trauma and completed the questionnaire again. Comparison tests, namely chi-square and logistic regression, were performed to assess the post-intervention responses and compare the differences between the groups. The results were interpreted with a significance level of 5% and a 95% confidence interval. Most responses showed a statistically significant difference (p < 0.05), indicating that the interventions improved teachers' knowledge, except for questions on time and immediate management after dentoalveolar trauma (p > 0.05). There was no statistical difference between the intervention methods, demonstrating that both the leaflets and videos improved teachers' knowledge (p > 0.05). The results revealed that teachers' knowledge of tooth avulsion improved regardless of the format of the educational intervention.

Pterygoid implant: extensometric and photoelastic analysis of a maxillary rehabilitation model.

Koga DH, Curi MM, Santiago Junior JF … +4 more , Pesqueira AA, Carvalho WJS, Campaner M, Cardoso CL

Braz Oral Res · 2025 · PMID 40105519 · Full text

Pterygoid implants have been demonstrated to have a high success rate. Nevertheless, there are few biomechanical tests to evaluate the tensile forces induced by force dissipation in peri-implant tissues. This study emplo... Pterygoid implants have been demonstrated to have a high success rate. Nevertheless, there are few biomechanical tests to evaluate the tensile forces induced by force dissipation in peri-implant tissues. This study employed photoelasticity and extensometry to demonstrate and compare the biomechanical behavior of non-axial implants in a pterygoid model and a conventional model of oral rehabilitation, thus allowing for qualitative and quantitative analysis. Two models received an implant measuring 3.75 x 13 mm in the canine pillar at a 90 ° angle to the Frankfurt plane. In the control group, an implant with a diameter of 3.75 mm and a length of 11 mm was placed in the maxillary tuberosity parallel the medial implant. In the study group, an implant with a diameter of 3.75 mm and a length of 11 mm was installed with an angulation of 45 degrees in the antero-posterior direction and 15 degrees in the buccal-palatal direction, with apical anchorage in the pterygoid process of the sphenoid bone. In the extensometric analysis, the models were subjected to five cycles of repeated axial tensile loading (100 N) at a rate of 0.5 mm/min. A computer was connected to the amplifier in order to record the output signal of the polyurethane surface, and the acquisition system software was employed to record the data. The data were analyzed in accordance with data distribution, as determined by the Shapiro-Wilk test and equality of variance. Subsequently, the data were classified according to the variables. The Student's t-test was employed when normal distribution of variances was identified, whereas the Mann-Whitney U test was utilized for data with non-normal distribution. A 5% significance level was employed. In the photoelastic analysis, replicas of both configurations were produced using photoelastic resin. The models were subjected to a single axial loading cycle, with a load of 100 N applied at a rate of 0.5 mm/min, and the resulting stress was observed under a circular polariscope. Photographs were taken at two time points: before and after loading. These images were then processed by the same operator using a computer graphics program, allowing for a more straightforward analysis of stress distribution. This was achieved by the formation of isochromatic fringes. The results of the strain gauge analysis revealed no statistically significant differences between the two groups (p = 0.37) or between the anterior (p = 0.08) and posterior (p = 0.74) implants. The photoelasticity analysis revealed the presence of high-intensity isochromatic fringes at the apex of the axial implant in the control model, as well as in the cervical-distal and apical regions of the pterygoid implant, where a high concentration was also observed. Although no statistically significant results were obtained from the quantitative analysis, our findings suggest that the favorable outcomes observed in the clinical studies are due to the high force dissipation observed in the pterygoid plate, which is composed of dense cortical bone.

The impact of intracanal medicaments on crown color, pH, and antimicrobial activity: a comparative study.

Siqueira PC, Soares LDCC, Wanderley KRDM … +5 more , Deus LB, Melo HV, Ávila MPA, Estrela LRA, Estrela CRA

Braz Oral Res · 2025 · PMID 40105518 · Full text

This study aimed to compare the effects of intracanal medication pastes Bio-C Temp® (BC), UltraCal XS® (UC), and Pure Calcium Hydroxide (CH) on crown color change, pH, and antimicrobial activity. Color change was assesse... This study aimed to compare the effects of intracanal medication pastes Bio-C Temp® (BC), UltraCal XS® (UC), and Pure Calcium Hydroxide (CH) on crown color change, pH, and antimicrobial activity. Color change was assessed using the CIEL*a*b* color space system parameter. pH values were measured at 3, 24, 72, and 168 hours. Antimicrobial activity was evaluated using agar diffusion and direct exposure tests. Statistical analyses were conducted using ANOVA, Kruskal-Wallis, and Friedman tests (α = 0.05). After 15 days, BC exhibited significantly greater color variation than the control, and higher L* values at 60 days compared to baseline (p < 0.05). BC demonstrated lower pH values than UC and CH at 3 and 72 hours (p < 0.05). In the agar diffusion test, BC produced a smaller microbial inhibition halo than UC and CH. In the direct exposure test, CH completely inhibited microbial growth, whereas BC showed microbial growth at all evaluated time points. In conclusion, BC resulted in greater crown color change, lower pH, and reduced antimicrobial activity compared to UC and CH.

Effects of radiation therapy on the morphology and composition of root dentin and cementum in primary teeth.

Cadilho JCR, Mira PCDS, Bem JP … +7 more , Rodrigues PS, Thomé FJQ, Oliveira HF, Torres FM, Paula-Silva FWG, Nelson-Filho P, Queiroz AM

Braz Oral Res · 2025 · PMID 40008740 · Full text

The aim of this study was to evaluate, in vitro, the effects of radiation therapy on the morphology and chemical composition of root dentin and cementum of primary teeth. Roots of human primary teeth were exposed to vary... The aim of this study was to evaluate, in vitro, the effects of radiation therapy on the morphology and chemical composition of root dentin and cementum of primary teeth. Roots of human primary teeth were exposed to varying doses of irradiation using a linear accelerator: Group 1 = irradiation dose of up to 30 Gy (n= 6); Group 2 = irradiation dose of up to 42 Gy (n= 6); and Group 3 = irradiation dose of up to 54 Gy (n= 6). Non-irradiated human deciduous teeth were used as controls (n= 3). Energy-dispersive X-ray spectroscopy (EDX) data were analyzed using the chi-square test (alpha = 5%). The morphological evaluation was performed using scanning electron microscopy (SEM). In the cementum, radiation increased inorganic composition and decreased oxygen levels. However, no morphological changes were observed. In the root dentin, obliterated dentinal tubules were observed in specimens irradiated with 54 Gy, with no changes in composition. Thus, radiation therapy significantly altered the morphology and composition of important tooth structures such as dentin and cementum, in primary teeth.

Caries risk factors among Indonesian adults: insights from the national health survey.

Rachmawati YL, Putri AH, Priyanto R … +3 more , Nabilah KC, Gani ADS, Mohd-Dom TN

Braz Oral Res · 2025 · PMID 40008739 · Full text

Although caries is a preventable disease, it is still a health burden in all countries in all age categories. This study aimed to identify the determinants associated with caries risk factors in Indonesian adults. This s... Although caries is a preventable disease, it is still a health burden in all countries in all age categories. This study aimed to identify the determinants associated with caries risk factors in Indonesian adults. This secondary analysis used 2018 National Health Survey data, which included 37,057 respondents aged ≥ 15 years. The sampling design was based on census blocks selected using linear systematic sampling with probability proportional to size (PPS). The survey included an interview to collect data on sociodemographic characteristics, oral health practice, and health behavior. An oral examination was conducted to measure the DMFT (decayed, missing, filled- teeth) index. Multivariable models were generated to estimate the odds ratio (OR) and confidence intervals (95% CI) using caries as the dependent variable. The highest average DMFT index was seen in those respondents aged over 45 years, those from rural areas, individuals with low formal education, those who consumed sweets and sugary beverages at least once a day, those who did not brush their teeth regularly, and those who smoked. The multivariable analysis showed the potential risk of caries: risk of 19.51 times for older adults, 74% for male, 94% for those living in rural areas, 1.62 times for those with lower formal education, 78% for those with no dental visits, 1.18 times for those who eat sweets often, 1.37 times for those who drink sugary beverages often, 1.48 times for those who do not brush their teeth regularly, and 1.3 times for those who smoke. The multifaceted nature of caries in the Indonesian adult population highlights the influence of various factors, ranging from lifestyle habits and oral hygiene practices to access to dental services, age, and educational level.

Effect of pellicle modification with polyphenol-rich solutions on enamel erosion and abrasion.

Mailart MC, Berisha I, Reinales ASA … +4 more , Niemeyer SH, Borges AB, Baumann T, Carvalho TS

Braz Oral Res · 2025 · PMID 40008733 · Full text

The aim of the study was to compare the effect of salivary pellicle modification with polyphenol-rich solutions containing fluoride on enamel erosion and abrasion. Human enamel specimens (n = 14/group) were assigned to f... The aim of the study was to compare the effect of salivary pellicle modification with polyphenol-rich solutions containing fluoride on enamel erosion and abrasion. Human enamel specimens (n = 14/group) were assigned to five pellicle-modifying groups: GSE+F (grape seed extract +500 ppm F-); CRA+F (cranberry extract +500 ppm F-); NaF (sodium fluoride solution -5 00ppm F-); Sn+F (commercial solution, SnCl2/NaF/AmF); and DW (deionized water, negative control). The specimens were submitted to 5 cycles, each one consisting of pellicle formation (120μl, 30 min, 37°C, no agitation), followed by pellicle modification with the experimental solutions (5 ml, 2 min, 25ºC, 70 rpm), and subsequent salivary pellicle formation (120 μl, 60 min, 37°C, no agitation). The specimens were then submitted to erosion (1% citric acid, 10 ml, 1 min, pH 3.6, 70 rpm, 25ºC). Subsequently, they were submitted to abrasion with a fluoride-based toothpaste slurry in a toothbrushing machine (50 strokes, 200 g load, 2 min exposed to slurry). The enamel surface was evaluated with an optical profilometer at baseline and after the 5 cycles to assess the surface loss. Data were submitted to Kruskal-Wallis followed by a multiple comparisons test (α = 0.05). Significant differences were found between the tested solutions (p <0.001). The highest surface loss was verified in the DW group (p < 0.001). The other tested solutions (GSE+F, CRA+F, Sn+F, NaF) promoted significant enamel protection against the erosive-abrasive challenges with no differences between them. In conclusion, the modification of salivary pellicle with both polyphenol-rich, commercial solution and fluoride solutions were able to protect the enamel surface from erosion and abrasion.

Bone mineral density in patients using aromatase inhibitors: a clinical, nutritional, and quality of life assessment.

Souza AF, Barra SG, Rocha AL … +16 more , Bemquerer LM, Oliveira SR, Carvalho LN, Amaral TMP, Brasileiro CB, Costa FO, Souza LN, Camargos BM, Lima EM, Ferreira AVM, Heredia JE, Oliveira MC, Macari S, Abreu LG, Mesquita RA, Silva TA

Braz Oral Res · 2025 · PMID 40008732 · Full text

The use of aromatase inhibitors (AIs) leads to an imbalance in bone remodeling and can cause osteoporosis. This study aimed to identify clinical, periodontal, nutritional, and biochemical determinants of bone mineral den... The use of aromatase inhibitors (AIs) leads to an imbalance in bone remodeling and can cause osteoporosis. This study aimed to identify clinical, periodontal, nutritional, and biochemical determinants of bone mineral density (BMD) changes in patients using AIs. The sample consisted of 40 women using AIs and 32 controls. BMD was assessed by dual X-ray absorptiometry (DXA). Data on nutritional, anthropometric, oral and periodontal status, and oral health-related quality of life (OHRQoL) were collected. Cytokines and adipokines were quantified in saliva and serum. Thirty-nine of the 72 women had low BMD, with a similar distribution in the control and AIs groups. BMD was lower in older women using AIs (p = 0.009) and in smokers (p = 0.034). Anthropometric assessment demonstrated that women with low BMD who used AIs had lower weight (p = 0.028). Although the frequency of periodontitis was similar in all groups, higher IL-6 (p = 0.004), IL-1β (p = 0.002), and IL-33 (p = 0.006) levels were associated with poor periodontal status. Women who used AIs were 1.18 times more likely to report better OHRQoL than controls. While advanced age, smoking, and lower weight are factors associated with low BMD, the use of antiresorptive agents was a protective factor for maintaining BMD in women using AIs.

Presentation of a new multifunctional oral cavity simulator: the "MOCS".

Maske TT, Cenci MS, Patzlaff R … +4 more , Mocs I, Hashizume LN, Maltz M, Arthur RA

Braz Oral Res · 2025 · PMID 40008731 · Full text

This article describes a new multifunctional oral cavity simulator (MOCS) that allows, with little technical support and easy handling, the laboratory development of dental hard tissue lesions under clinically similar co... This article describes a new multifunctional oral cavity simulator (MOCS) that allows, with little technical support and easy handling, the laboratory development of dental hard tissue lesions under clinically similar conditions. The MOCS consists of a heating unit containing three independent cylindrical chambers with three specimen holders inside. Liquids flow through the surfaces of specimens by inlets on the lid of the chamber, which is connected to a medium/artificial saliva source through a computer-controlled peristaltic pump. The design, operational principles, and clinical application of this simulator, such as microcosm-induced development of carious-like lesions, acidic-induced erosion-abrasion like-lesions, and testing the anticariogenic effect of restorative materials, are shown. The MOCS can mimic several aspects of the oral cavity, being a promising device for assessing dental hard tissue lesions.

Structural equation modeling of the association between oral health literacy and dental caries in children.

Lima LCM, Neves ÉTB, Perazzo MF … +5 more , Bernardino VMM, Silva SED, Paiva SM, Ferreira FM, Granville-Garcia AF

Braz Oral Res · 2025 · PMID 40008730 · Full text

The aim of this study was to explore the association between oral health literacy (OHL) and dental caries in children, evaluating the direct and indirect effects of brushing frequency, obesity, and socioeconomic factors.... The aim of this study was to explore the association between oral health literacy (OHL) and dental caries in children, evaluating the direct and indirect effects of brushing frequency, obesity, and socioeconomic factors. A cross-sectional study was conducted with 739 schoolchildren aged eight to ten years and their parents/caregivers who answered a questionnaire addressing sociodemographic characteristics and oral hygiene habits as well as the OHL - Adult Questionnaire. Cavitated dental caries in the schoolchildren was evaluated using International Caries Detection and Assessment System criteria. Descriptive analysis was performed, followed by structural equation modeling into the theoretical model (95% CI). Goodness-of-fit indices were considered satisfactory (root mean square error of approximation < 0.06; comparative fit index > 0.90-0.95; standardized root mean square residual < 0.10 and Tucker-Lewis Index > 0.90-0.95). Mother's age (standardized coefficient [SC]: -0.08; p < 0.01), caregiver's schooling (SC: -0.22; p < 0.01), obesity (SC: 0.13; p < 0.01), and brushing frequency (SC: -0.09; p < 0.01) had a direct effect on dental caries, whereas OHL had an indirect influence on the outcome. Mother's age, caregiver's schooling, brushing frequency, and obesity directly affected the occurrence of cavitated carious lesions in children in the mixed dentition phase, whereas OHL had an indirect effect on this clinical outcome.

Patient-centered factors associated with orthodontic treatment success: a scoping review.

Santana LG, Gatti-Reis L, Paiva SM … +2 more , Ramos-Jorge ML, Marques LS

Braz Oral Res · 2025 · PMID 40008729 · Full text

The aim of this systematic review was to synthesize the available literature on pretreatment factors, from a patient-centered perspective, that predict successful orthodontic treatment. Systematic and unrestricted search... The aim of this systematic review was to synthesize the available literature on pretreatment factors, from a patient-centered perspective, that predict successful orthodontic treatment. Systematic and unrestricted searches were conducted across the electronic MEDLINE, Embase, Web-of-Science, Scopus, Cochrane Library, and LILACS/Bireme databases. Grey literature was also searched to identify potential studies. Qualitative assessments of the role of patient-centered pretreatment factors in orthodontic treatment success (adherence, satisfaction, and discontinuation rates) were evaluated and synthesized. Study selection and data extraction were performed independently by two reviewers. A total of sixteen studies were included. Three main domains related to the patient emerged as positive predictors of orthodontic treatment success: previous patterns of social behavior, attitudes of parents/caregivers, and reasonable motivation. Certain personality traits were associated with both positive and negative levels of adherence and treatment satisfaction. The evidence did not support the notion that the impact of malocclusion on aesthetic self-perception could serve as an indicator of cooperation, satisfaction, or discontinuation rates related to orthodontic treatment. Positive social behavior patterns and parental/caregiver attitudes, along with realistic prior motivation toward treatment goals, were found to be reliable predictors of orthodontic treatment success. Additionally, some personality traits were found to be associated with successful treatment outcomes. However, the evidence did not support the impact of malocclusion on self-perceived aesthetics as an indicator of compliance and satisfaction levels with orthodontic treatment.

Properties of 3D-Printed resins for interim restorations: effects of printing and post-curing protocols.

Pacheco LE, Cassiano FB, Stuani VT … +7 more , Silva ISPD, Alamo L, Costa MC, Lovison MF, Ishikiriama SK, Mondelli RFL, Soares DG

Braz Oral Res · 2025 · PMID 40008728 · Full text

This study analyzed the properties of three-dimensional (3D)-printed resins designed for interim restorations and subjected to different printing and post-curing protocols. Specimens were manufactured with two 3D-printed... This study analyzed the properties of three-dimensional (3D)-printed resins designed for interim restorations and subjected to different printing and post-curing protocols. Specimens were manufactured with two 3D-printed resins for interim restorations at varying exposure times per layer, in accordance with the manufacturer's recommendations (Tm) or using a calibrator (Tc). Subsequently, the specimens were post-cured for 5, 10, or 15 min. Trueness, surface roughness, and color analyses were performed. For biological characterization, the specimens were incubated for up to 72 h in a culture medium, and the extracts were applied at 24-h intervals to keratinocyte cells (NOK-Si). Cellular metabolism was evaluated after 1 and 3 days. Leaching of residual monomers from the extracts was evaluated. Data were analyzed using two-way analysis of variance (ANOVA) and Tukey's honestly significant difference (HSD) test (α = 5%). The exposure time beyond Tc resulted in specimens with increased trueness and smoother surfaces. Color stability was also influenced by the type of resin and post-curing time; the longer the time, the greater the color change, allowing for brighter and clearer specimens. The resins were cytocompatible with NOK-Si, regardless of the printing and post-curing parameters, although residual monomer leaching was affected by the parameters tested. The evaluated resins were cytocompatible; however, variations in the exposure times per layer and post-curing duration affected their roughness, leaching, trueness, and color stability.

Carbon fiber-reinforced PEEK as a framework material for single implant-retained mandibular overdentures.

Borges GA, Mesquita MF, Matias LFDS … +3 more , Barbin T, Machado LMR, Barão VAR

Braz Oral Res · 2025 · PMID 39936717 · Full text

This study aimed to assess the biomechanical behavior of reinforcement materials [cobalt chromium alloy (CoCr) and carbon fiber-reinforced polyether ether ketone (CFR-PEEK)] and their extensions (short: 15 mm and long: 2... This study aimed to assess the biomechanical behavior of reinforcement materials [cobalt chromium alloy (CoCr) and carbon fiber-reinforced polyether ether ketone (CFR-PEEK)] and their extensions (short: 15 mm and long: 25 mm) of single implant-retained mandibular overdentures (MO-1) by 3D finite element analysis (FEA), comparing them with MO-1 without a framework. Five models (CoCr-Short, CFR-PEEK-Short, CoCr-Long, CFR-PEEK-Long, and no framework) were created using the McNeel Rhinoceros 3D software, version 7.0. Stress distribution analysis by FEA was performed using the Optstruct solver, and a 30° oblique load (100 N) was applied in the anterior region (50 N on each central incisor). Biomechanical behavior was analyzed by overdenture displacement, maximum (MaxP) and minimum principal (MinP) stress, and von Mises stress. The MO-1 model 'without a framework' produced the largest dislocation, MinP stress on the mucosa, and MaxP stress in the cortical bone. Regardless of the extension of the framework, CFR-PEEK had minor MinP stress in the mucosa and lower overdenture displacement. The 'CoCr-Long' and 'CFR-PEEK-Long' models had higher von Mises stress on the implant housing, and MaxP stress on the O'ring nylon conventional implant and overdenture. The 'CoCr-Short' and ' CFR-PEEK-Short' models showed a greater tendency for tension concentration solely in the framework. The incorporation of a framework into MO-1 decreased stress concentration on the overdenture, resulting in lower stress on the attachment, mucosa, implant, and peri-implant bone, irrespective of the material used. The short framework, however, performed better biomechanically in MO-1, and it is therefore the most recommended option. CFR-PEEK showed favorable biomechanical outcomes, and is suggested for reinforcement of MO-1.

Aging and post-polymerization effects on conversion degree and properties of additive splint materials.

Santis LR, Fernandes LS, Vasques MT … +5 more , Zambrana NRM, Viana ÍEL, Forlin TS, Saavedra GSFA, Francci CE

Braz Oral Res · 2025 · PMID 39936716 · Full text

The study objective was to analyze dimensional change, flexural strength, surface hardness, wear profile, and conversion degree of different additive splint materials under various post-polymerization conditions of time... The study objective was to analyze dimensional change, flexural strength, surface hardness, wear profile, and conversion degree of different additive splint materials under various post-polymerization conditions of time and artificial aging. Two additive manufacturing systems (Cara Print 4.0, Dima Print Ortho, Kulzer; SprintRay Pro, SprintRay Splint, SprintRay), and a thermally activated resin control (Clássico) were evaluated in artificial aging (deionized water or saliva; 28 or 84 days at 37°C), with recommended or doubled post-polymerization cycles. Dimensional change (surface metrology), flexural strength (ISO 20795-1:2013), fractography (SEM), Knoop hardness, two-body wear profilometry (150,000 cycles; 3mmØ; 20N; 2.1Hz), and conversion degree (FTIR spectroscopy) were assessed. Two-way ANOVA and post-hoc Tukey tests were used for parametric data, and Kruskal-Wallis and post-hoc Dunn tests, for non-parametric data (α = 0.05). Results indicated no statistically significant differences in dimensional change or flexural strength among the materials. Recommended post-polymerization cycles resulted in lower hardness for additive resins than the thermally activated control. Doubling post-polymerization time significantly increased flexural strength and hardness of Dima Print Ortho, but decreased flexural strength of SprintRay Splint, and did not affect wear resistance. Dima Print Ortho demonstrated the highest wear resistance. Artificial aging did not affect flexural strength, surface wear, or dimensional change, but negatively impacted the hardness of all materials except Dima Print Ortho. The conversion degree was unaffected by post-polymerization time, and no significant differences were found among the materials. Overall, additive materials exhibited mechanical and dimensional properties comparable to thermally activated resin, with doubling post-polymerization time positively influencing the properties.

Occlusion, acid resistance, and elemental characterization of dentin treated with desensitizing agents.

Ribeiro MCLS, Ferreira BAJ, Ribeiro ACF … +4 more , França FMG, TURSSi CP, Basting RT, Vieira-Junior WF

Braz Oral Res · 2025 · PMID 39936715 · Full text

The objective of this study was to evaluate the occlusion potential of in-office desensitizing agents, and characterize the human dentin elements after acid exposure. Twelve human dentin discs were sectioned into four sp... The objective of this study was to evaluate the occlusion potential of in-office desensitizing agents, and characterize the human dentin elements after acid exposure. Twelve human dentin discs were sectioned into four specimens each, and randomized into treatments (n = 20): no treatment (negative control); no treatment and 6% citric acid exposure (positive control); application of Gluma desensitizer (Heraeus Kulzer) or PRG Barrier Coat (Shofu), followed by 6% citric acid exposure. Occlusion and dentin surface characteristics were determined by scanning electron microscopy (SEM, n = 10), and elemental composition (at%), by energy-dispersive X-ray spectroscopy (EDS, n = 10). Three calibrated, blinded evaluators used SEM to categorize the occlusion potential: 1 = occluded, 2 = partially unoccluded, 3 = equally occluded/unoccluded, 4 = partially occluded, 5 = unoccluded. Data were analyzed by weighted kappa, Friedman, and Nemenyi tests (α = 0.05). For SEM, mean occlusion scores were higher for the PRG Barrier Coat than the positive control (p = 0.0235). Most specimens in the controls scored 4 or 5. The most frequent scores for PRG Barrier Coat were 1(60%) and 2(20%), while 30% of Gluma specimens scored 1 and 2. Gluma showed intratubular precipitation, while PRG Barrier Coat covered dentinal tubules totally or partially. For EDS, the K% was lower for Gluma than the negative control (p = 0.0046), with Si peaks in dentin treated with PRG Barrier Coat. The bioactive in-office desensitizing agent with S-PRG filler (PRG Barrier Coat) promoted dentin tubule occlusion, and persisted after exposure to acid.

Dental discrepancies in black adolescents: evaluating impacts on well-being.

Langoski JÉ, Meira ACLO, Santamaria-Junior M … +3 more , Menezes CC, Meneghim MC, Vedovello SAS

Braz Oral Res · 2025 · PMID 39936714 · Full text

The aim of this study was to compare the esthetic, functional, and psychosocial impact of mandibular crowding and maxillary midline diastema in black adolescents. A cross-sectional study was conducted with 420 black (bro... The aim of this study was to compare the esthetic, functional, and psychosocial impact of mandibular crowding and maxillary midline diastema in black adolescents. A cross-sectional study was conducted with 420 black (brown and black, distinguished according to Brazilian Institute of Geography and Statistics - IBGE) adolescents aged 12 with normal occlusal relationships. Esthetic (OASIS) and functional/psychosocial (OHIP-14) impact related to the need for orthodontic treatment in groups with mandibular crowding and maxillary midline diastema, and those without these conditions: G1, without crowding and diastema (n 113); G2, without crowding and with diastema (n 67); G3, with crowding and without diastema (n 202); and G4, diastema, and crowding (n 38) were evaluated. Generalized linear models were estimated for the effects of diastema, crowding, and the interaction between them, with a significance level of 5%. There was no significant influence of crowding and diastema on the OHIP-14 (p>0.05). However, the groups with diastema had higher OASIS scores, irrespective of crowding (p<0.05). The maxillary midline diastema influenced the esthetic perception of black adolescents.

Principles of radiological protection and application of ALARA, ALADA, and ALADAIP: a critical review.

Mendonça RP, Estrela C, Bueno MR … +3 more , Carvalho TCASG, Estrela LRA, Chilvarquer I

Braz Oral Res · 2025 · PMID 39936713 · Full text

This study carried out a critical review of the principles of radioprotection, including the ALARA, ALADA, and ALADAIP principles. The Google Scholar and PubMed databases were the search resources, and the following keyw... This study carried out a critical review of the principles of radioprotection, including the ALARA, ALADA, and ALADAIP principles. The Google Scholar and PubMed databases were the search resources, and the following keywords were searched: Linear No-Threshold (LNT); Biologic Effects of Ionizing Radiation (BEIR VII); As Low As Reasonably Achievable (ALARA); As Low As Diagnostically Acceptable (ALADA); As Low As Diagnostically Acceptable, being Indication-oriented and Patient-specific (ALADAIP). This critical review included studies with historical references, reviews, position papers, and clinical and experimental studies. Regarding data extraction, only original articles were selected after the screening process. Much of the current evolution of X-ray machines and radioprotection protocols has stemmed from legitimate concerns about this topic. This development has grown out of the relevant work of organizations like ICRP, UNSCEAR, and other renowned international organizations. Low doses of radiation, such as those used for diagnosis, also occur naturally and are present in everyday life. Although there is no agreement on the actual risk involving low doses, the recommendations of ALARA, ALADA, and ALADAIP prevail, in line with the trend to uphold principles that balance the importance of X-ray diagnostic imaging with the intention of keeping the doses as low as possible. The benefits of X-ray exams, when justified, tend to outweigh the low risks attributed to them.

Impact of polyethylene fiber-reinforced composite resin and thermomechanical cycling on dentin bond strength.

Pimentel MIGCR, Kantovitz KR, Turssi CP … +4 more , Amaral FLBD, Basting RT, Martins LM, França FMG

Braz Oral Res · 2025 · PMID 39936712 · Full text

This study evaluated the microtensile bond strength (μTBS) and fracture pattern of direct composite resin reinforced with polyethylene fiber (Ribbond®) on dentin substrate after thermomechanical cycling (TMC). Dentin blo... This study evaluated the microtensile bond strength (μTBS) and fracture pattern of direct composite resin reinforced with polyethylene fiber (Ribbond®) on dentin substrate after thermomechanical cycling (TMC). Dentin blocks (dentin thickness=2 mm) were obtained from forty human third molars and randomly divided into four groups (n=10) according to type of restoration (composite resin with or without Ribbond®) and to whether they were or were not subjected to TMC (100,000 cycles of 50 N / 2 Hz / 1-minute baths of 5 and 55ºC). The 1-mm-thick square-shaped specimens were submitted to μTBS testing in a universal testing machine at 0.5 mm/min. The fracture patterns were assessed by stereoscopic magnifying glass (30X magnification). The μTBS (in MPa) and failure pattern data were subjected to the generalized linear model and G tests (a=0.05). Neither the polyethylene fiber nor TMC had any statistically significant effect (p=0.196 and p=0.136, respectively) on the μTBS of the composite resin to dentin. Adhesive failures were more prevalent in the composite resin group compared with the Ribbond-containing group when subjected to TMC. Additionally, the composite resin containing Ribbond® showed a higher proportion of cohesive failures in composite resin than the resin groups not containing this fiber, irrespective of TMC. It was concluded that reinforcing the direct layer of composite resin with Ribbond® polyethylene fiber did not influence the adhesive resistance to dentin, even when subjected to TMC. However, its incorporation did result in a higher frequency of cohesive failures in resin after TMC.

Impact of orthodontic treatment with aligners and fixed appliances on OHRQoL: a randomized clinical trial.

Borsato TT, Bittencourt JM, Paiva SM … +5 more , Conti ACCF, Fernandes TMF, Almeida-Pedrin RR, Almeida MR, Oltramari PVP

Braz Oral Res · 2025 · PMID 39936711 · Full text

The aim of this study was to assess the impact of orthodontic treatment with orthodontic aligners (OAs) and fixed appliances (FAs) on oral health-related quality of life (OHRQoL). This parallel randomized clinical trial... The aim of this study was to assess the impact of orthodontic treatment with orthodontic aligners (OAs) and fixed appliances (FAs) on oral health-related quality of life (OHRQoL). This parallel randomized clinical trial included 40 male and female patients aged 13 to 35 years diagnosed with Angle's Class I malocclusion. Participants were assigned to two groups: OA (n = 20) and FA (n = 20). OHRQoL was assessed using the Brazilian OHIP-14, which was administered before treatment (T0), at 1 month (T1), 6 months (T2), and 12 months (T3) after treatment initiation. Data were analyzed using the independent t test, the chi-square test, the Mann-Whitney test, and Friedman test (p < 0.05). FAs had a significantly (p < 0.05) higher impact on OHRQoL at T1 in terms of functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, and overall score. Within-group comparison showed higher scores for the FA group in comparison to the OA group. Functional limitation scores were higher at T1 than at T0 (p = 0.034), while physical pain scores were higher at T1 compared to T0 (p = 0.034) and T2 (p = 0.010). Psychological discomfort scores were higher at T1 than at T2 (p = 0.015). Physical disability scores were higher at T1 compared to T0 (p = 0.008). Overall scores were higher at T1 than at T2 (p = 0.003). No significant changes were observed in the OA within-group comparison. Patients treated with OAs had less impact on OHRQoL compared to those treated with FAs in the first month. There was no difference between the groups at the 6-month follow-up.

Application of artifact suppression algorithm of post-processing CBCT software in root canal filling materials.

Estrela C, Endo MM, Bueno MR … +3 more , Azevedo BC, Decurcio DA, Estrela LRA

Braz Oral Res · 2025 · PMID 39907325 · Full text

OBJECTIVES: Cone beam computed tomography (CBCT) is an imaging exam used increasingly in various fields of dentistry, and a greater number of endodontists are progressively gaining access to this technology. This study f... OBJECTIVES: Cone beam computed tomography (CBCT) is an imaging exam used increasingly in various fields of dentistry, and a greater number of endodontists are progressively gaining access to this technology. This study focused on applying an artifact suppression algorithm featured in CBCT software, and designed specifically to address artifacts related to root canal filling materials. METHOD: The sample consisted of eighty-four mandibular molars, with mesial root canals endodontically treated by using the lateral condensation technique. Four root canal sealers were applied: G1 - Sealapex®, G2 - AH Plus®, G3 - Endofill®, and G4 - Bio-C Sealer. CBCT scans were taken using PreXion 3D Elite®. Initially, the diameter of the root canal filling (in the mesiodistal and buccolingual directions) was measured using a digital micrometer (control). Next, these diameters were reevaluated in the CBCT images using the blooming artifact reduction (BAR) tool of the e-Vol DX software. The Van der Waerden nonparametric analysis of variance was performed, followed by applying the Tukey test to the normalized data. The significance level was set at α = 5%. RESULTS: There were no statistically significant differences (p>0.05) in the measurement of original root canal filling materials obtained by the micrometer versus the e-Vol DX software in the mesiodistal and buccolingual directions. CONCLUSIONS: The tested software algorithm effectively suppressed artifacts resulting from obturation materials.
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