Evidence-based Medicine[JOURNAL]

Farah WH, Alsawas M, Mainou M … +15 more , Alahdab F, Farah MH, Ahmed AT, Mohamed EA, Almasri J, Gionfriddo MR, Castaneda-Guarderas A, Mohammed K, Wang Z, Asi N, Sawchuk CN, Williams MD, Prokop LJ, Murad MH, LeBlanc A

Evid Based Med · 2016 Dec · PMID 27836921 · Publisher ↗

BACKGROUND: The comparative effectiveness of non-pharmacological treatments of depression remains unclear. METHODS: We conducted an overview of systematic reviews to identify randomised controlled trials (RCTs) that comp... BACKGROUND: The comparative effectiveness of non-pharmacological treatments of depression remains unclear. METHODS: We conducted an overview of systematic reviews to identify randomised controlled trials (RCTs) that compared the efficacy and adverse effects of non-pharmacological treatments of depression. We searched multiple electronic databases through February 2016 without language restrictions. Pairs of reviewers determined eligibility, extracted data and assessed risk of bias. Meta-analyses were conducted when appropriate. RESULT: We included 367 RCTs enrolling ∼20 000 patients treated with 11 treatments leading to 17 unique head-to-head comparisons. Cognitive behavioural therapy, naturopathic therapy, biological interventions and physical activity interventions reduced depression severity as measured using standardised scales. However, the relative efficacy among these non-pharmacological interventions was lacking. The effect of these interventions on clinical response and remission was unclear. Adverse events were lower than antidepressants. LIMITATION: The quality of evidence was low to moderate due to inconsistency and unclear or high risk of bias, limiting our confidence in findings. CONCLUSIONS: Non-pharmacological therapies of depression reduce depression symptoms and should be considered along with antidepressant therapy for the treatment of mild-to-severe depression. A shared decision-making approach is needed to choose between non-pharmacological therapies based on values, preferences, clinical and social context.

Get PDF PubMed ↗

Intraoperative on-table endoscopic retrograde cholangiopancreatography (ERCP) is better than laparoscopic bile duct exploration for concomitant bile duct stones during emergency laparoscopic cholecystectomy.

Garg PK, Bansal VK

Evid Based Med · 2017 Mar · PMID 27836920 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Height of head centre of gravity predicts paediatric head injury severity in short-distance falls.

Hu J

Evid Based Med · 2017 Mar · PMID 27834662 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Cognitive adverse effects and brain deterioration associated with use of anticholinergic activity medicines in older adults.

Nishtala PS, Salahudeen MS

Evid Based Med · 2016 Dec · PMID 27815304 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Pitfalls of administrative database analysis are evident when assessing the 'weekend effect' in stroke.

Attenello FJ, Mack WJ

Evid Based Med · 2017 Mar · PMID 27815303 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Uncertainty in evidence synthesis limits clinical applicability of a clinical and cost-effectiveness analysis of induction of labour methods.

Davidson C

Evid Based Med · 2016 Dec · PMID 27811000 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding.

Miedema MD, Virani SS

Evid Based Med · 2016 Dec · PMID 27780831 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Evidence pyramids.

Kaufmann J

Evid Based Med · 2016 Dec · PMID 27777251 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Letter in reply to 'Evidence pyramids' from Dr Kaufmann.

Shaneyfelt T

Evid Based Med · 2016 Dec · PMID 27777250 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Where should preappraised evidence summaries and guidelines place in a pyramid?

Alahdab F, Alsawas M, Murad MH

Evid Based Med · 2016 Dec · PMID 27777249 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Letter in reply to 'Evidence pyramids' from Dr Kaufmann.

Alper BS, Haynes BR

Evid Based Med · 2016 Dec · PMID 27777248 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Morphine exposure in preterm infants correlates with impaired cerebellar growth and poorer neurodevelopmental outcome.

McPherson C

Evid Based Med · 2016 Dec · PMID 27760778 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

In individuals at intermediate risk for cardiovascular disease, treatment with rosuvastatin but not candesartan plus hydrochlorothiazide lowers cardiovascular disease event rates.

LeFevre M

Evid Based Med · 2016 Dec · PMID 27758802 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

'Spin' in reports of clinical research.

Mahtani KR

Evid Based Med · 2016 Dec · PMID 27737894 · Publisher ↗

Clinical research is frequently hampered by flaws in its design or conduct. Such biases have been well documented. However, reports of clinical research may also be biased and present results in a more favourable way tha... Clinical research is frequently hampered by flaws in its design or conduct. Such biases have been well documented. However, reports of clinical research may also be biased and present results in a more favourable way than they deserve or downplay harms. Such 'spin' in reporting has been demonstrated empirically. This short commentary summarises some of the problems with spin in reports of clinical research as well as signposts to some of the empirical evidence demonstrating its effect.

Get PDF PubMed ↗

Evidence-based Medicine[JOURNAL]

About