Searches / Evidence-based Medicine[JOURNAL]

Evidence-based Medicine[JOURNAL]

Sun 200 papers
RSS

Value and usability of unpublished data sources for systematic reviews and network meta-analyses.

Halfpenny NJ, Quigley JM, Thompson JC … +1 more , Scott DA

Evid Based Med · 2016 Dec · PMID 27686328 · Publisher ↗

Peer-reviewed publications and conference proceedings are the mainstay of data sources for systematic reviews and network meta-analyses (NMA), but access to informative unpublished data is now becoming commonplace. To ex... Peer-reviewed publications and conference proceedings are the mainstay of data sources for systematic reviews and network meta-analyses (NMA), but access to informative unpublished data is now becoming commonplace. To explore the usefulness of three types of 'grey' literature-clinical trials registries, clinical study reports and data from regulatory authorities-we conducted four case studies. The reporting of outcome data in peer-reviewed publications, the clinical trials registries and the clinical study reports for two clinical trials-one in melanoma, one in juvenile idiopathic arthritis (JIA)-was examined. In addition, we assessed the value of including unpublished data from the European Medicines Agency (EMA) and US Food and Drug Administration (FDA) in evidence syntheses of hepatitis C virus (HCV) and chronic obstructive pulmonary disease (COPD), respectively. For the clinical trials in melanoma and JIA, we identified outcome parameters on ClinicalTrials.gov additional to those reported in the peer-reviewed publications: subgroup data and additional efficacy end points/extended follow-up, respectively. The clinical study report also provided results for several subgroups unavailable elsewhere. For HCV and COPD, additional outcome data were obtained from the EMA European Public Assessment Report (EPAR) and the FDA, respectively, including data on subgroups and mortality. We conclude that data from these grey literature sources have the potential to influence results of systematic reviews and NMAs, and may thus have implications for healthcare decisions. However, it is important to consider carefully the availability, reliability and consequent usability of these data sources in systematic reviews and NMAs.
Get PDF PubMed ↗

Careful monitoring of fetal growth and maternal nutritional status should be practiced in pregnant women with a history of bariatric surgery.

Neovius M, Stephansson O

Evid Based Med · 2016 Dec · PMID 27679667 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Most add-on therapies to metformin have similar effects on HbA1c.

Karagiannis T, Bekiari E

Evid Based Med · 2016 Dec · PMID 27679666 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Determination of a single, universal threshold for caesarean section rate is not the way forward.

Betrán AP, Zhang J, Torloni MR … +1 more , Gülmezoglu AM

Evid Based Med · 2016 Dec · PMID 27664175 · Full text

Abstract loading — click title to view on PubMed.

Free PDF PubMed ↗

Avoiding alert fatigue in pulmonary embolism decision support: a new method to examine 'trigger rates'.

Press A, Khan S, McCullagh L … +4 more , Schachter A, Pardo S, Kohn N, McGinn T

Evid Based Med · 2016 Dec · PMID 27664174 · Full text

A clinical decision support system (CDSS) is integrated into the electronic health record (EHR) and allows physicians to easily use a clinical decision support (CDS) tool. However, often CDSSs are integrated into the EHR... A clinical decision support system (CDSS) is integrated into the electronic health record (EHR) and allows physicians to easily use a clinical decision support (CDS) tool. However, often CDSSs are integrated into the EHR with poor adoption rates. One reason for this is secondary to 'trigger fatigue'. Therefore, we developed a new and innovative usability process named 'sensitivity and specificity trigger analysis' (SSTA) as part of our larger project around a pulmonary embolism decision support tool. SSTA will enable programmers to examine optimal trigger rates prior to the integration of a CDS tool into the EHR, by using a formal method of analysis. We performed a retrospective chart review. The outcome of interest was physician ordering of a CT angiography (CTA). Phrases that signify common symptoms associated with pulmonary embolism were assessed as possible triggers for the CDSS tool. We then analysed each trigger's ability to predict physician ordering of a CTA. We found that the most sensitive way to trigger the Pulmonary Embolism CDS tool while still maintaining a high specificity was by combining 1 or more pertinent symptoms with 1 or more elements of the Wells criteria. This study explored a unique methodology, SSTA, used to limit inaccurate triggering of a CDS tool prior to integration into the EHR. This methodology can be applied to other studies aiming to decrease triggering rates and increase adoption rates of previously validated CDSS tools.
Free PDF PubMed ↗

Low-dose second-generation oral contraceptives are associated with the lowest increased risk of cardiovascular adverse effects.

Løkkegaard E

Evid Based Med · 2016 Dec · PMID 27655112 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

LABA/LAMA combinations instead of LABA/ICS combinations may prevent or delay exacerbations of COPD in some patients.

Cazzola M, Rogliani P

Evid Based Med · 2016 Dec · PMID 27634637 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Implementing evidence-based practices improves neonatal outcomes.

Lee SK

Evid Based Med · 2016 Dec · PMID 27634636 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Traditionally taught clinical variables and risk factors perform poorly in the prediction of acute coronary syndromes in the emergency department.

Than M

Evid Based Med · 2016 Dec · PMID 27600188 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome.

Ryerson L, Garcia Guerra G, Lequier L

Evid Based Med · 2016 Dec · PMID 27586148 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Physical activity reduces cardiovascular disease risk in older adults.

Endes S

Evid Based Med · 2016 Oct · PMID 27581544 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

High consumption of potatoes may increase risk of developing type 2 diabetes.

Ning Y, Zhang C

Evid Based Med · 2016 Oct · PMID 27581543 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Childhood non-specific abdominal pain may predict adulthood organic and functional abdominal disease in a small number of patients.

Paajanen H

Evid Based Med · 2016 Oct · PMID 27574192 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Acupuncture may be considered to be an effective tool for patients with frequent episodic or chronic tension-type headache.

Liu Y, Yu S

Evid Based Med · 2016 Oct · PMID 27565945 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Protease inhibitor monotherapy was non-inferior and cost-effective as maintenance therapy compared to triple therapy in viral load suppressed patients with HIV-1 infection.

Ripamonti D

Evid Based Med · 2016 Oct · PMID 27565944 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Are eponyms used correctly or not? A literature review with a focus on shoulder and elbow surgery.

Somford MP, Nieuwe Weme RA, van Dijk CN … +2 more , IJpma FF, Eygendaal D

Evid Based Med · 2016 Oct · PMID 27565943 · Publisher ↗

BACKGROUND: Eponymous terms are used frequently in daily patient care and scientific literature. They remind us of our predecessors in surgery. It is debatable whether eponymous terms are reliable in case of information... BACKGROUND: Eponymous terms are used frequently in daily patient care and scientific literature. They remind us of our predecessors in surgery. It is debatable whether eponymous terms are reliable in case of information transfer. The aim of our study was to investigate whether the original meaning of eponymous terms in shoulder and elbow surgery has been preserved in its use in contemporary literature. OBJECTIVE: To evaluate whether eponymous terms were used correctly, we analysed the use of frequently encountered eponymous terms from January to December 2014. STUDY SELECTION: By means of a PubMed search, articles with eponymous terms were identified and analysed for the way an eponymous term was used, and we compared it with the original description. The original description was traced back to the index publication. The use of the eponymous term was scored as similar, divergent or undefined. In the search for eponymous terms, we included those eponymous terms that were used more than 10 times in the English, German and Dutch literature of 2014. 6 eponymous terms were eligible for analysis: Bankart lesion, Bristow-Latarjet procedure, Essex-Lopresti injury of the forearm, Galeazzi fracture, Hill-Sachs lesion and Monteggia fracture. FINDINGS: We analysed 96 articles with the listed eponymous terms, of which 27 (28%) were scored divergent, 32 (33%) undefined and 37 (39%) similar. Bristow-Latarjet scored lowest, with 0% descriptions similar to the original, meaning that all articles had an undefined or divergent eponym, and Essex-Lopresti scored highest with 82% similarity. CONCLUSIONS: Eponymous terms in shoulder and elbow trauma and surgery are used inadequately and inconsistently. The use of eponymous terms probably cannot be avoided, but since the majority of eponymous terms are not used properly and understanding of its meaning and content varies from surgeon to surgeon, we should be keen on explaining the meaning of eponymous terms when using them.
Get PDF PubMed ↗

Lack of a significant relationship between energy intake in pregnancy and gestational weight gain underlines the need for further evaluations of energy metabolism during this time.

Bell R, Robson P

Evid Based Med · 2016 Oct · PMID 27565942 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Diet-heart disease hypothesis is unaffected by results of analysis of recovered data from Minnesota Coronary Experiment.

Skeaff CM, Mann JI

Evid Based Med · 2016 Oct · PMID 27559090 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Metformin reduces weight gain in overweight/obese adolescents with type 1 diabetes.

Sharma AM

Evid Based Med · 2016 Oct · PMID 27555640 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗

Smokers with respiratory symptoms but no airflow limitation, often have activity limitation, exacerbations and evidence of airway disease.

Ulrik CS

Evid Based Med · 2016 Oct · PMID 27555639 · Publisher ↗

Abstract loading — click title to view on PubMed.

Get PDF PubMed ↗
← Prev Page 8 of 10 Next →

About

Frequency
Sun
Papers found
200
RSS feed
Subscribe