Journal Of Obstetrics And Gynaecology Of India[JOURNAL]
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200 papers
Impact of Kinesio Taping on Pregnancy related Pelvic Girdle Pain and Disability.
Bano B, Nigam A, Malhotra D … +1 more , Rais Z
J Obstet Gynaecol India · 2025 Oct · PMID 41180430 · Full text
AIM: To discover out the impact of Kinesio Taping (KT) in reduction of pain and disability experienced by pregnant females. METHOD: Total 30 pregnant females in second trimester were recruited after fulfilling inclusion...
AIM: To discover out the impact of Kinesio Taping (KT) in reduction of pain and disability experienced by pregnant females. METHOD: Total 30 pregnant females in second trimester were recruited after fulfilling inclusion and exclusion criteria. They were randomized into 2 group. Experimental (A) received KT and Control group (B) sham KT. KT or sham KT was applied on day 1 and removed on day 5. Pain and disability were the results measures of the study. The pain levels were assessed by utilizing Visual Analogue Scale (VAS) on 1st day before treatment (BF) and after treatment (AF), 3rd day, 5th day and 7th day. Disability was evaluated using Oswestry Disability Index in Hindi Version, on day 1 and day 7. RESULTS: Preintervention both the groups were comparable regarding Pain and Oswestry Disability Index (ODI) scores. Post intervention experimental group had markedly decreased VAS and ODI from day 1 to day 7 (VAS Day 1 BF: 43.66 ± 17.31 Vs VAS Day 7: 26.13 ± 13.74; ODI Day 1: 31.80 ± 12.36 Vs ODI Day 7: 17.66 ± 7.30; p < 0.05). In control group VAS and ODI remained same between Day 1 & 7 (VAS Day 1 BF 31.93 ± 14.08, Vs VAS Day 7 32.46 ± 13.68;, ODI Day 1 22.13 ± 15.35 Vs ODI Day 7 22.00 ± 11.73). CONCLUSIONS: KT can significantly reduce PGP and disability in pregnant females as compared to sham taping, measured by VAS and ODI scale respectively.
Pregnancy Outcomes in Women with Super Obesity.
Ravula PC, Shah AG, Bansal G
J Obstet Gynaecol India · 2025 Aug · PMID 40852351 · Full text
INTRODUCTION: Women with high Body Mass Index (BMI) are at increased risk of maternal and perinatal complications. These complications range from diabetes, hypertensive disorders, preterm births, increased rates of cesar...
INTRODUCTION: Women with high Body Mass Index (BMI) are at increased risk of maternal and perinatal complications. These complications range from diabetes, hypertensive disorders, preterm births, increased rates of cesarean births, anesthesia related challenges, macrosomic fetuses, fetal anomalies, stillbirths, postpartum hemorrhage and surgical site infections. In this study, maternal and perinatal outcomes of women with BMI > 50 kg/m from a single center are presented. AIMS AND OBJECTIVES: The primary objective was to determine the risk of maternal and fetal complications in super obese pregnant women. The secondary objective was to study the incidence of super obesity in the study population. METHODOLOGY: This was a retrospective cohort study conducted over eleven years (January 2013-December 2023) at Fernandez Hospital, a tertiary perinatal care center with approximately 8000 births per annum. Data were sourced from electronic medical records. The study group included women with singleton pregnancies with BMI ≥ 50 kg/m, birthed at the center and the control group included all other women. RESULTS: The overall incidence of super obesity (BMI ≥ 50 kg/m) was 1 in 1000 births. On comparing women with various BMI ranges, there was a significant increase in maternal complications such as chronic hypertension, pregnancy induced hypertension, pregestational diabetes mellitus, gestational diabetes mellitus and hypothyroidism ( < 0.001) as the BMI increased. Super obese women experienced high rates of cesarean section (54%, = 0.009), fetal growth abnormalities like small for gestational age (12%, = 0.017), large for gestational age (17%, < 0.001) and stillbirths (1%, = 0.001). CONCLUSION: Adverse maternal and perinatal outcomes are directly proportional to maternal obesity. This emphasizes that these women should be managed at a dedicated clinic for comprehensive multidisciplinary care.
Risk Factor Analysis of Gestational Diabetes Mellitus Across Urban India: Findings from the Pregnancy Study Group.
Gokalani R, Sanghvi A, Karlhanis S … +9 more , Sankar P, Panchal D, Dengra A, Saboo B, Kota S, Saiyed M, Saboo B, Jaggi S, Chawla R
J Obstet Gynaecol India · 2025 Aug · PMID 40852350 · Full text
BACKGROUND: GDM is an intermediate phase in a woman's life that certainly poses a high risk of type 2 diabetes. Maternal health affects the health of offspring, a precursor of the vicious cycle of diabetes that continues...
BACKGROUND: GDM is an intermediate phase in a woman's life that certainly poses a high risk of type 2 diabetes. Maternal health affects the health of offspring, a precursor of the vicious cycle of diabetes that continues through generations. Knowing the causative factors of GDM is important to breaking this cycle. OBJECTIVE: To study the risk factors of GDM in Indian women. METHOD: The observational study database records from 2022 to 2023 from 11 different centres across India. We included pregnant women diagnosed with GDM with any OGTT criteria and excluded women with pre-existing diabetes. RESULTS: A total of 431 women with GDM were included in the study. 166 women were diagnosed with GDM in the 3rd trimester, followed by 235 women in the 2nd trimester, and 30 women in the 1st trimester of pregnancy. Those detected with GDM during the 1st trimester had a BMI of 27.9 kg/m2, followed by 28.3 and 29.3 kg/m2 in 3rd trimester. Multigravida showed a positive correlation with a family history of T2D (0.04), previous history of GDM (-value < 0.001), history of stillbirth (-value < 0.001) and hypertension (-value 0.03). CONCLUSION: Pre-pregnancy BMI and women's age at family planning are two important risk factors for the prevention of gestational diabetes.
Triptorelin 0.1 mg as a Luteal Phase Support in Antagonist Intracytoplasmic Sperm Injection Cycles.
Zahran KM, Ahmed MMA, Farghaly TA … +2 more , Elsayed AA, El-Nashar IM
J Obstet Gynaecol India · 2025 Aug · PMID 40852349 · Full text
BACKGROUND: Transvaginal progesterone is used to aid throughout the luteal phase. Administering a dose of gonadotrophin-releasing-hormone analogues (GnRHa) six days following OPU in GnRH antagonist cycles might cause ris...
BACKGROUND: Transvaginal progesterone is used to aid throughout the luteal phase. Administering a dose of gonadotrophin-releasing-hormone analogues (GnRHa) six days following OPU in GnRH antagonist cycles might cause rise in pituitary gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)), leading to rise in steroid synthesis (estradiol (E2) and progesterone (P)) by the corpora lutea (CL). This work aimed to contrast the effect of lipopolysaccharides (LPS) with adding GnRHa to progesterone P, at day six after ovum pickup versus P alone, on the clinical pregnancy rate. METHODS: This open labeled randomized controlled trial study was carried out at women health hospital (WHH), Assiut University on 150 women with antagonist controlled ovarian hyperstimulation protocol (COH). Individuals had been categorized into two groups: Study group: include women who obtained 0.1 mg of GnRH agonist "triptorelin" at day 6 after OPU in addition to (P) since day of oocyte pickup (OPU) compared with the control group: administration of P only since (OPU) as LP support. RESULTS: Women who received GnRHa 0.1 mg & P as LPS were reported significant higher progesterone level, beta human chorionic gonadotropins (BHCG) level, fetal pulsation, implantation rate, clinical pregnancy rate, biochemical pregnancy rate, ongoing pregnancy and live birth rates contrasted to control group ( < 0.05). CONCLUSION: Adding GnRHa to P as LPS is associated with significant higher progesterone level at day 7 after OPU BHCG day 14 of embryo transfer, clinical pregnancy rate, biochemical pregnancy rate, implantation rate, ongoing pregnancy rate, and live birth rate.
Role of Metformin in Preeclampsia: A Systematic Review.
Anuja M, Arthy M, Jha N … +3 more , Ashok MV, Jha AK, Sivaranjani P
J Obstet Gynaecol India · 2025 Aug · PMID 40852348 · Full text
BACKGROUND: Preeclampsia is a leading cause of maternal and newborn morbidity and mortality. Metformin prevents preeclampsia by improving cardiovascular function and reducing gestational weight gain. AIM: The aim of syst...
BACKGROUND: Preeclampsia is a leading cause of maternal and newborn morbidity and mortality. Metformin prevents preeclampsia by improving cardiovascular function and reducing gestational weight gain. AIM: The aim of systematic review was to summarize the role of metformin in preeclampsia and report on outcomes of role of metformin in preeclampsia. OBJECTIVE: To assess the maternal and perinatal outcomes among women with preclamsia with or without metformin supplementation in addition to usual care. METHOD: We searched for publications indexed in PubMed, Web of Science, Psyc INFO, and CINAHL databases using a combination of terms such as "metformin" AND "preeclampsia" OR "hypertension" AND "gestation." RESULTS: Four empirical studies were identified as relevant to our study. We discovered that the incidence of severe preeclampsia was significantly lower in those who received metformin than in those who did not (12.1% vs. 20.7%, aOR 0.38, 95% CI 0.18-0.81). Metformin treatment significantly reduced the incidence of preeclampsia ( = 0.04) and intrauterine growth restriction ( = 0.035) compared to the control group. One week after taking metformin, maternal sEng and sFLT-1 levels were considerably reduced. CONCLUSIONS: Our findings reveal that Metformin significantly reduced the frequency of superimposed preeclampsia and associated factors in a pregnant woman with chronic hypertension. When compared to other drugs, metformin is more likely to avoid pregnancy-related hypertension disorders. The small number of studies studied, combined with their clinical diversity, make it impossible to generalise these findings to larger groups. Therefore, well designed randomised trials on the use of metformin for the prevention and treatment of pre-eclampsia are essential.
Recurrent Male Neonatal Deaths in a Heterozygous X-linked Ornithine Transcarbamylase Deficiency Carrier Pregnant Woman.
Nath B, Kanti V, Baranwal A
J Obstet Gynaecol India · 2025 Aug · PMID 40852347 · Full text
Ornithine transcarbamylase (OTC) deficiency is the most common enzyme deficiency of the urea cycle which converts toxic ammonia to urea for its excretion from the body. Symptoms due to the deficiency of the enzyme result...
Ornithine transcarbamylase (OTC) deficiency is the most common enzyme deficiency of the urea cycle which converts toxic ammonia to urea for its excretion from the body. Symptoms due to the deficiency of the enzyme results in accumulation of ammonium and glutamine in the body. This manifests as vomiting, lethargy, cerebral oedema and coma. In affected male babies born with the metabolic disorder, there is severe neonatal hyperammonaemia. Due to the rarity of the metabolic disorder, diagnosis is delayed with fatal consequences for the newborn. We report here a case of recurrent neonatal deaths in an asymptomatic mother heterozygous for X-linked OTC gene mutation.
Accuracy in Fetal Weight Estimation by Ultrasound: A Comparative Study of Hiwale and Hadlock Methods in a Tertiary Care Hospital.
Ganesh S, Jyothi GS, Poojashree KS
J Obstet Gynaecol India · 2025 Aug · PMID 40852346 · Full text
BACKGROUND: Of all the methods available for fetal weight estimation, ultrasound-based estimation is the commonly used noninvasive and widely available technique. Different population-based models use a combination of fe...
BACKGROUND: Of all the methods available for fetal weight estimation, ultrasound-based estimation is the commonly used noninvasive and widely available technique. Different population-based models use a combination of fetal measurements for the estimation of fetal weight by ultrasound. Models developed for non-Indian populations give erroneous fetal weight estimates when used for Indian populations. Therefore, there is an immense need to develop an Indian-based model for sonographic fetal weight estimation. This study assesses the fetal weight from different available formulae and compares them with the actual birthweight. METHODOLOGY: This was a prospective study of 154 women assessed by ultrasound within a week of delivery. Ultrasonogram was done and head circumference, biparietal diameter, abdominal circumference and femur length were measured and estimated fetal weight was calculated using Hadlock's formula and Hiwale formula. Actual birth weight of the baby was measured after the delivery. Estimated fetal weight predicted by each formula was compared with respective neonatal actual birth weight. RESULTS: Out of 154 pregnant women included in the study, 92.8% were of average reproductive age-group, i.e., 20-34 years with minimum age being 18 year and maximum age is 42 year. Birth weight ranged from 780 to 4200 gms, with a mean of 2619.6. Low birthweight babies constituted 34.3% ( = 53). In our study, when weight was calculated using Hiwale method nearly 25.3% of cases had overestimated and 74.7% had underestimated the fetal weight, out of it 45.5% of cases were within the range of ± 10% of the actual birthweight. The difference between mean estimated fetal weight and mean actual birth weight was 194.5 g. CONCLUSION: Hadlock's method of fetal weight estimation was found to be more accurate.
Fetal Anomalies: An Obstetrician's Overview.
Dalvi S
J Obstet Gynaecol India · 2025 Aug · PMID 40852345 · Full text
Fetal anomalies-also known as congenital anomalies or birth defects-are unusual conditions that affect fetus during pregnancy. It can affect one or multiple organs, can be structural or functional and range from mild, mo...
Fetal anomalies-also known as congenital anomalies or birth defects-are unusual conditions that affect fetus during pregnancy. It can affect one or multiple organs, can be structural or functional and range from mild, moderate to severe. Fetal anomalies are present in 3-5% of live births. Congenital anomalies are usually detected in prenatal period during anomaly scan around 18-20 weeks. Some may be detected during NT-NB scan (11-14 weeks) or in third trimester. The risk factors could be genetic, environmental or both, and sometimes, no cause is detected. Some anomalies can resolve after birth, or some may need corrective therapy with special monitoring during antenatal period at specialized center. Patients with fetal anomaly incompatible with life, detected before 24 weeks of gestation, are advised to undergo termination, and those beyond 24 weeks, special permission is needed for termination. Early detection and timely intervention are helpful to improve outcome. Children with fetal anomalies are likely to have physical, intellectual, cognitive impairment leading to emotional stress in family. Awareness with regard to nutritional supplements and folic acid needs to be created, and high-risk factors like diabetes, obesity and certain medications need to be taken care of. Those with genetic predisposition needs thorough counseling, detailed investigations and possibility of treatment with pre-genetic diagnosis (PGD) for next pregnancy.
A Comparative Study Between Continuous and Interrupted Suturing of Rectus Sheath Closure in Caesarean Section Patients at a Tertiary care Teaching Hospital.
Saroj S, Narkhede HR, Chavan R … +2 more , Karale A, Wanjare N
J Obstet Gynaecol India · 2025 Aug · PMID 40852344 · Full text
BACKGROUND: Caesarean delivery may be followed by several complications, surgical site infection (SSI) being one of them. The rate of SSI ranges from 3 to 15% worldwide (1-6). SSI is associated with a maternal mortality...
BACKGROUND: Caesarean delivery may be followed by several complications, surgical site infection (SSI) being one of them. The rate of SSI ranges from 3 to 15% worldwide (1-6). SSI is associated with a maternal mortality rate of up to 1.33%. (3) It places physical and emotional burdens on the mother and her family. AIM: Study aimed to compare incidence of incisional SSI in two techniques of rectus sheath closure: the conventional continuous method and intermittent in patients undergoing caesarean section. METHODS: Comparative observational study of total 578 patients who underwent caesarean sections was enrolled in the study. These were divided into two equal groups of 289 each and assigned as either continuous or intermittent rectus sheath closure group. Standard surgical steps and post-operative care given to all. Wound complications were analysed in both groups. RESULTS: Out of total 578 LSCS studied, we have found 47 SSI (8.1%); 10 (3.4%) SSI found in intermittent rectus sheath closure group which is less than in continuous group, 37 (12.8%). Intermittent closure group is associated with less induration, pain at the wound site, serous discharge, and spontaneous superficial dehiscence. Resuturing need was less in intermitant group but significant difference not noted between the two groups (p = 0.651). CONCLUSION: Intermittent suturing of rectus sheath is associated with a lower incidence of SSI and fewer clinical manifestations compared to continuous suturing in caesarean section. Adopting the intermittent suturing technique for rectus sheath closure would significantly reduce post-operative complications like wound discharge, wound dehiscence, and improve patient outcomes.
Maternal and Fetal Outcomes in Gestational Diabetes Mellitus Treated with Metformin with or Without Insulin.
Kumar A, Muthukrishnan J, Patel A … +1 more , Kiran BC
J Obstet Gynaecol India · 2025 Aug · PMID 40852343 · Full text
BACKGROUND: Gestational Diabetes Mellitus (GDM) is linked with a multitude of adverse perinatal outcomes. There is a want for standard guidelines regarding the usage of Metformin in GDM. We aimed to study the perinatal o...
BACKGROUND: Gestational Diabetes Mellitus (GDM) is linked with a multitude of adverse perinatal outcomes. There is a want for standard guidelines regarding the usage of Metformin in GDM. We aimed to study the perinatal outcomes in women diagnosed with GDM treated primarily with Metformin with or without Insulin. METHODS: We conducted a randomized controlled pilot study. with a total of 75 women, divided into three groups: GDM treated with Metformin with or without Insulin (Group M), GDM on Insulin alone (Group I), and healthy pregnant women as controls (Group H), with 25 subjects in each group. At delivery, fetal and maternal outcomes were documented. RESULTS: The mean age in groups M, I and H were 27.4, 26.2, and 27.3 years respectively. The baseline mean HOMA-IR were 3.9 and 4.1 for Group M and Group I, respectively (-0.560). The mean fetal birth weight was 2.95 ± 0.54 kg, 2.8 ± 0.41 kg, and 2.97 ± 0.65 kg in Groups M, H, and I, respectively ( = 0.527). The mean newborn HOMA-IR in Groups M and I was 1.8 ± 0.4 and 1.7 ± 0.5, respectively ( = 0.185). The adverse events in newborns were 20% ( = 5), 16% ( = 4) and 16% ( = 4) in Groups M, H, and I respectively ( = 0.403). The incidence of caesarean deliveries was 40% ( = 10), 48% ( = 12) and 24% ( = 6) in Groups M, H, and I respectively (-0.253). CONCLUSION: The study revealed identical maternal and fetal outcomes in women treated with Metformin as the primary drug compared to conventional treatment with Insulin in GDM.
A Rare Riding Horse on the Ovary: Metastatic Neuroendocrine Tumour from Liver.
Kumar A, Gupta A, Phulware RH
J Obstet Gynaecol India · 2025 Aug · PMID 40852342 · Full text
Neuroendocrine tumours are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. Many are benign, while some are malignant. Neuroendocrine tumours of the ovary are rare and of uncertain histoge...
Neuroendocrine tumours are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. Many are benign, while some are malignant. Neuroendocrine tumours of the ovary are rare and of uncertain histogenesis. They may be primary or metastatic. Primary as well as metastatic neuroendocrine tumour to ovary is extremely rare. The distinction between primary and secondary ovarian tumours is critical since therapy and prognosis differ. Herein, we report a case of a metastatic hepatic neuroendocrine tumour (Grade-2) to ovary which is an uncommon condition, so that both clinician and pathologist will get enlighten with the occurrence of this rare entity. We believed that this was a wonderful chance to raise awareness of neuroendocrine neoplasms, which are quite uncommon in gynecological practices.
Changing Dynamics of Management in Fetus Near Viability at 23 Weeks to a Successful Outcome.
Bansal V, Bansal V
J Obstet Gynaecol India · 2025 Aug · PMID 40852341 · Full text
Fetus near viability approaching hospitals for care is increasing in number in India. However, the lack of evidence and experience may make an obstetrician reluctant to treat fetuses of 22-26 weeks gestation. The present...
Fetus near viability approaching hospitals for care is increasing in number in India. However, the lack of evidence and experience may make an obstetrician reluctant to treat fetuses of 22-26 weeks gestation. The present case demonstrates the intact survival of a 23.5-week-old baby with a multidisciplinary approach. Moreover, we have tried to summarize our hospital protocol for obstetrics and neonatal management to optimize the outcome.
Health of Indian Midlife Women-Unmet Needs and Possible Solutions.
ArunKarthik M, Shyjus P
J Obstet Gynaecol India · 2025 Aug · PMID 40852340 · Full text
With increase in the longevity of life, the population of women in midlife and older is increasing. Midlife marks a challenging period of a women's life where hormonal changes and menopausal transition occur and the inci...
With increase in the longevity of life, the population of women in midlife and older is increasing. Midlife marks a challenging period of a women's life where hormonal changes and menopausal transition occur and the incidence of non-communicable diseases increases. This period of life experience depends on various factors such as ethnicity, country of residence, literacy and socioeconomic class. Gender itself is a key factor that determines an individual's health. The need for a healthy lifestyle from early on needs to be emphasized as it plays a key role in healthy aging. There is also a need to spread awareness on prevention of NCDs and good post-retirement support. National health programs must include older adults and specialized and personalized care given according to their needs. This will help prevent health deterioration in midlife that reduces functional ability, work productivity and increased healthcare costs, leading to economic loss.
Comparison of Sub-foveal Choroidal Thickness in Patients with Hypertensive Disorders of Pregnancy Versus Normotensive Pregnant Women in Third Trimester.
Sanjana M, Suma KB, Soumya HV
J Obstet Gynaecol India · 2025 Aug · PMID 40852339 · Full text
BACKGROUND: Hypertensive disorders of pregnancy (HDP), is a leading cause of morbidity and mortality in both the mother and the fetus. These disorders often lead to significant systemic and ocular changes, particularly i...
BACKGROUND: Hypertensive disorders of pregnancy (HDP), is a leading cause of morbidity and mortality in both the mother and the fetus. These disorders often lead to significant systemic and ocular changes, particularly in the choroidal vasculature. The sub-foveal choroidal thickness (SFCT) may provide critical insights into these changes and serve as a non-invasive marker for assessing the severity of HDP. OBJECTIVE: The study aimed to compare the SFCT in patients with HDP versus normotensive pregnant women in their third trimester and to correlate SFCT with the severity of hypertension. METHODS: This cross-sectional study was conducted at JSS Hospital, Mysuru, involving 100 pregnant women in their third trimester, divided into 51 cases (HDP group) and 49 controls (normotensive group). SFCT was measured using spectral domain optical coherence tomography (SD-OCT). Data was analyzed and SFCT values compared between the two groups using mean arterial pressure (MAP). RESULTS: Results showed significantly higher SFCT in the HDP group (229.76 μm) compared to controls (173.45 μm), with a -value < 0.001. The HDP group also had a notably higher MAP (115.07 mmHg vs. 87.63 mmHg), and a positive correlation ( = 0.541, < 0.001) was found between MAP and SFCT. CONCLUSION: The study demonstrates that SFCT is significantly increased in patients with HDP, correlating positively with MAP. Further studies are recommended to explore the broader clinical applications of SFCT in HDP.
Identification of Spatial Hot spots Clustering and Geographically Weighted Regression Analysis to Assess Predictors of Cesarean Section Delivery in Northeastern States, India.
Singh KJ, Khan MA, Kumar K … +5 more , Alee NT, Sharma S, Yadav J, Bakshi RK, Mukherjee R
J Obstet Gynaecol India · 2025 Aug · PMID 40852338 · Full text
BACKGROUND: It is difficult to achieve health related Sustainable Development Goals when a higher proportion of birth delivery occurs through cesarean section (CS) than vaginal delivery without considerable medical benef...
BACKGROUND: It is difficult to achieve health related Sustainable Development Goals when a higher proportion of birth delivery occurs through cesarean section (CS) than vaginal delivery without considerable medical benefits. This study aims to identify the spatial hot spot clustering and determinants of cesarean section in northeastern states, India. METHODS: The study utilized data from the fifth round of the National Family Health Survey (NFHS-5, 2019-2021), which included responses from 34,222 mothers who delivered live births in the five years preceding the survey. The study investigated spatial hot spot clustering of CS prevalence using Getis-Ord Gi* statistics and applied multiscale geographically weighted regression (MGWR) to identify spatial clusters in the relationships between predictor variables and CS delivery. RESULTS: The study identified spatial hot spot clustering of CS rates in districts of Sikkim, western and southern Tripura, eastern and western Assam, and central Manipur. MGWR results indicated that significant determinants of CS include maternal age (30-49 years), first birth order, highest educational level, high body mass index, and highest wealth quintile, with regression coefficients varying significantly by district in this region. CONCLUSION: The study found that CS rates vary by clusters in the districts of northeastern states of India. It suggests that piloting educational interventions for pregnant women and regularly monitoring CS facilities could be initial strategies to better understand and address the higher CS trends in these regions.
Fetoscopic Reduction and Closure for Complex Gastroschisis: A Novel Minimally Invasive Prenatal Approach.
Callado GY, Araujo Júnior E, Tsujita AS … +7 more , Tomimatsu WT, Silva E Silva A, Pereira RMF, Chagas MC, Ianni CL, Silva GG, Saito M
J Obstet Gynaecol India · 2025 Aug · PMID 40852337 · Full text
UNLABELLED: Gastroschisis is a congenital defect where fetal intestines herniate through an abdominal wall opening. Although postnatal surgical repair is standard, fetal surgery via fetoscopic techniques is emerging as a...
UNLABELLED: Gastroschisis is a congenital defect where fetal intestines herniate through an abdominal wall opening. Although postnatal surgical repair is standard, fetal surgery via fetoscopic techniques is emerging as a potential intervention, particularly for complex cases. This case report documents a fetoscopic technique for in utero gastroschisis correction with favorable outcomes. A fetoscopic surgery for gastroschisis was performed at 29 weeks of gestation. Using ultrasound guidance, a fetoscope and two trocars were introduced into the amniotic cavity to reposition the herniated intestines into the fetal abdomen and close the abdominal wall defect with a continuous suture. The procedure was completed in 80 min, with fetal vitality monitored during surgery. A live female newborn was delivered by cesarean section at 32 weeks of gestation for premature rupture of ovular membranes, weighing 1620 g. The newborn demonstrated appropriate gastrointestinal function and was discharged at 14 days without the need for further surgical interventions. This case report demonstrates the feasibility and safety of fetoscopic repair of gastroschisis, resulting in favorable neonatal outcomes, including early discharge without additional surgery. The approach warrants further investigation by randomized clinical trial to evaluate its benefits compared to standard postnatal treatment for gastroschisis, especially in complex suspect cases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13224-025-02187-5.
Pulmonary Vein PI, Cardiac Function and Remodeling in SGA Fetuses`.
Swami V, Dadhwal V, Sharma KA … +5 more , Perumal V, Rana A, Sahay N, Meena J, Kulshrestha V
J Obstet Gynaecol India · 2025 Aug · PMID 40852336 · Full text
BACKGROUND: To investigate the myocardial performance index (MPI), global sphericity index (GSI) and pulmonary vein pulsatility index (PVPI) changes in FGR fetuses in an Indian population. METHOD: In this prospective obs...
BACKGROUND: To investigate the myocardial performance index (MPI), global sphericity index (GSI) and pulmonary vein pulsatility index (PVPI) changes in FGR fetuses in an Indian population. METHOD: In this prospective observational study, 70 fetuses from 26 weeks to term were recruited into two groups: 35 fetuses with appropriate growth (controls) and 35 with EFW < 10th centile, which were further classified into SGA ( = 14) and FGR ( = 21) based on vessel Doppler parameter (umbilical artery PI > 95th centile, CPR < 5th centile). PVPI, MPI and GSI were measured and compared among groups. RESULT: Mean PVPI was increased in FGR 0.91 ± 0.23 compared to controls 0.79 ± 0.19 ( = 0.021) and showed an increasing trend across groups-controls, SGA and FGR. The mean GSI was decreased in FGR 1.16 ± 0.12 compared to controls 1.33 ± 0.33 ( = 0.047), indicating a more globular heart. Though the mean MPI did not show a statistically significant difference between the groups, its component ET (ejection time) was shorter in FGR 158.28 ± 17.81 compared to controls 165.54 ± 13.78 ( = 0.047). CONCLUSION: Growth-restricted fetuses undergo cardiac remodeling due to hemodynamic redistribution and show a decreased global sphericity index, indicating a more globular heart. Additionally pulmonary vein Doppler changes like increased PVPI reflect atrial dynamic changes which can be used as an early predictor of compromise as these occur before DV changes.
Impact of Male Age and Semen Parameters on Blastocyst Morphology, Beta-HCG Positivity and Pregnancy Viability: A Retrospective Analysis in Frozen Embryo Transfer Cycles.
Pande DB, Deshmukh H, Bhadauria S … +1 more , Tomar GS
J Obstet Gynaecol India · 2025 Jun · PMID 40584805 · Full text
BACKGROUND: This study was conducted to explore the impact of male age, sperm concentration and motility, on the blastocyst expansion, inner cell mass and trophectoderm grade of the blastocyst along with beta-HCG positiv...
BACKGROUND: This study was conducted to explore the impact of male age, sperm concentration and motility, on the blastocyst expansion, inner cell mass and trophectoderm grade of the blastocyst along with beta-HCG positivity and viability of pregnancy following a frozen embryo transfer. MATERIALS AND METHODS: Data from Indore Infertility Clinic from January 2021 to December 2023 were utilized. ICSI cycles with a single frozen embryo transfer were used for analysis. Statistical analyses were performed using STATA-13/IC software and Microsoft Excel Professional Plus 2021. RESULTS: No significant correlation was found between male age and sperm concentration or motility. A positive correlation between sperm concentration and motility was observed in autologous sperm samples. There was no significant association between male age, sperm concentration and sperm motility with blastocyst expansion, inner cell mass grade or trophectoderm grade. No significant association was found between male age, sperm concentration and sperm motility with beta-HCG. A significant association was observed between inner cell mass grade and beta-HCG positivity. No significant association was found between cardiac activity and blastocyst morphology, male age, sperm concentration and motility. CONCLUSION: This study did not reveal any significant associations between male age, semen parameters and blastocyst morphology. No association was found between male age, semen parameters to beta-HCG positivity and pregnancy viability. A significant association was found between quality of inner cell mass and beta-HCG positivity in autologous semen sample cases.
Primary Cytoreductive Surgery Versus Neoadjuvant Chemotherapy Followed by Surgery in Patients with Advanced Primary Epithelial Ovarian Cancer in Low Resources Setting: A Randomized Clinical Trial.
Abutaleb H, Hussien A, Khalaf M … +7 more , Badary DM, Ismail AM, Hassanein S, AlGizawy S, Moustafa SAM, Farghaly RMM, Abdel-Kawi AF
J Obstet Gynaecol India · 2025 Jun · PMID 40584804 · Full text
INTRODUCTION: Ovarian cancer (OV) stands as the deadliest female reproductive system malignancy. Globally, OV ranks as the seventh most prevalent cancer in women, with an estimated 240,000 new cases annually and being th...
INTRODUCTION: Ovarian cancer (OV) stands as the deadliest female reproductive system malignancy. Globally, OV ranks as the seventh most prevalent cancer in women, with an estimated 240,000 new cases annually and being the second most common malignancy among women in Egypt. OBJECTIVES: We investigate the efficacy of cytoreductive surgery in achieving complete tumor removal (R0 resection) in OV, compared to neoadjuvant chemotherapy followed by surgery. METHOD: This randomized controlled trial at Women Health Hospital, Asyut University, Egypt from 2020 to 2023. Eighty patients were randomized (1:1) to primary surgery (Group I) or NACT (Group II), followed by further randomization (1:1) within each group to bevacizumab-containing chemotherapy or chemotherapy alone. The primary outcome was the rate of complete tumor removal (R0 resection). Secondary outcomes included surgical complexity, operative time, complications, and survival rates. RESULTS: Baseline demographic characteristics were similar between the groups (no statistically significant differences). The mean age for group I and group II were (56.3 and 57.23, respectively). Whereas, the BMI for group I and group II were (32.56 and 33.2, respectively). In addition, both groups achieved no significant difference of complete tumor removal (31 vs. 27). However, group II demonstrated significantly shorter operative times (182.34 vs. 219.85 min, = 0.047), required fewer blood transfusions (9 vs. 21, value 0.006), and experienced shorter hospital stays (6.13 vs. 11.9 days, value < 0.001) compared to group I. Notably, no significant differences emerged in complication rates, progression-free survival (11.20 vs. 11.19 months), or overall survival (11.69 vs. 11.76 months) between the groups. CONCLUSION: Our study demonstrates that optimal cytoreduction is more feasible with NACT, with less surgical complexity, shorter operative duration, less blood transfusion and short hospital stay. The study was registered on clincaltrail.gov with number: NCT04257786. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13224-024-02061-w.
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Ravivarman AKN, Santhosh S, Ravindran R … +1 more , Shaji KS
J Obstet Gynaecol India · 2025 Jun · PMID 40584803 · Full text
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