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Patient Preference And Adherence[JOURNAL]

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Preliminary Psychometric Evidence of an Integrated Life Autonomy and Coherence Measure (LAC-Scale) in Community-Dwelling Adults.

Wu PC, Chen YJ, Lin KR … +6 more , Yang YC, Yang CH, Huang TH, Hung WC, Lin CY, Su FC

Patient Prefer Adherence · 2026 · PMID 42136954 · Full text

BACKGROUND: Life autonomy and coherence have been recognized as essential psychological resources that contribute to overall functioning and quality of life (QOL). However, there is a dearth of validated measures on life... BACKGROUND: Life autonomy and coherence have been recognized as essential psychological resources that contribute to overall functioning and quality of life (QOL). However, there is a dearth of validated measures on life autonomy and coherence in the literature, especially a culturally appropriate measure in East Asian contexts (eg, Taiwan). This study provides preliminary psychometric evidence for the Life Autonomy and Coherence Scale (LAC-Scale) in community-dwelling adults. Specifically, the present study aimed to develop the LAC-Scale and evaluate its initial psychometric properties. METHODS: The LAC-Scale was first developed using literature review, expert panel committee, and pilot testing; a 25-item LAC-Scale was then generated. Then, a total of 305 community-dwelling adults participated in the study (mean age = 44.47 years, SD = 18.20). The sample was predominantly female (68.20%) and highly educated, with 77.70% of participants having completed a college-level education or above. The sample consisted predominantly of highly educated adults and was primarily female. Participants completed the LAC-Scale and external measures on QOL, physical resilience, and health literacy. Exploratory factor analysis (EFA) was used to examine the factorial structure of the LAC-Scale. Internal consistency, item-total correlations, and concurrent validity (with external measures) of the LAC-Scale were evaluated as well. RESULTS: EFA results indicated a two-factor structure comprising "Life Autonomy and Daily Coherence" and "Life Meaning and Social Connectedness". Four items with factor loadings below 0.50 were deleted, resulting in a final 21-item scale. Both factors demonstrated excellent internal consistency (α and ω = 0.96-0.98). Significant associations were observed between LAC-Scale scores and external measures (r=0.31 to 0.55), supporting concurrent validity. CONCLUSION: The present study provides preliminary psychometric evidence supporting a two-factor structure of the LAC-Scale and high internal consistency across the scale and its subscales. The LAC-Scale may help identify individuals with lower autonomy and coherence who could benefit from targeted interventions. Further confirmatory factor analysis and longitudinal validation studies are warranted.

Impact of Continuous Nursing Intervention Delivered via Internet+ Platform on Inflammatory Responses in Ulcerative Colitis Patients.

Zhu J, Ren X, Wang Q … +1 more , Luo M

Patient Prefer Adherence · 2026 · PMID 42131789 · Full text

OBJECTIVE: To explore the application effect of continuity nursing intervention based on the "Internet +" platform in patients with ulcerative colitis (UC) and analyze its impact on patients' inflammatory responses. METH... OBJECTIVE: To explore the application effect of continuity nursing intervention based on the "Internet +" platform in patients with ulcerative colitis (UC) and analyze its impact on patients' inflammatory responses. METHODS: A retrospective analysis was conducted on the clinical data of 300 patients with ulcerative colitis who were treated in our hospital from February 1, 2022, to October 1, 2024. According to the difference in nursing modes, the patients were divided into a control group (150 cases) and an observation group (150 cases). The control group received conventional nursing, while the observation group received continuity nursing intervention based on the "Internet +" platform. The inflammatory responses (serum interleukin-17, IL-17; interleukin-23, IL-23; interleukin-25, IL-25) and quality of life indicators were compared between the two groups. RESULTS: The baseline data of the two groups were comparable with no significant difference, P>0.05. In terms of inflammatory response, the serum levels of IL-17 and IL-23 in the observation group were significantly lower than those in the control group, while the level of IL-25 was significantly higher than that in the control group (P<0.05). The compliance rates of various indicators of treatment compliance in the observation group were significantly higher than those in the control group (P<0.05). In addition, the anxiety and depression scores of the observation group patients were significantly lower than those of the control group, and the scores of the psychological quality scale were better than those of the control group. The ESCA, IBD-SES, and IBDQ scores were significantly higher than those of the control group (P<0.05). CONCLUSION: Continuity nursing intervention based on the "Internet +" platform can significantly improve the intervention effect in patients with ulcerative colitis, associated with improved inflammatory markers, enhance treatment adherence, self-care ability and self-efficacy, and improve patients' psychological well-being and quality of life. It is worthy of promotion.

Applying the COM-B Model to Understand Adherence to Tele-Exercise Prehabilitation Among Older Patients with Lung Cancer: A Qualitative Study.

Liu CQ, Liu MY, Chu H … +3 more , Zhang Z, Huan SS, Ma YR

Patient Prefer Adherence · 2026 · PMID 42124921 · Full text

OBJECTIVE: To investigate the factors influencing adherence to exercise prehabilitation among elderly frail lung cancer patients under telemedicine management within the COM-B framework, and to inform the development of... OBJECTIVE: To investigate the factors influencing adherence to exercise prehabilitation among elderly frail lung cancer patients under telemedicine management within the COM-B framework, and to inform the development of a targeted remote prehabilitation intervention program. METHODS: This study employed purposive sampling to select 14 elderly frail lung cancer patients from a tertiary hospital in China as participants for semi-structured interviews. The data were subsequently transcribed and analyzed through qualitative inductive content analysis. RESULTS: The following themes and subthemes were identified. Capability: (1) experience a relatively heavy symptom burden; (2) difficulty in adjusting to negative emotions; (3) digital divide among the elderly; (4) strong ability in proactive health behaviors. Opportunity: (1) remote information-assisted support; (2) incentives based on group exercise formats; (3) a sense of belonging within a multidimensional social support network; (4) excessive concerns from family caregivers; (5) facility convenience and affordability; (6) personalized exercise plans with dynamic adjustments. Motivation: (1) perceived benefits of rehabilitation outcomes and quality of life; (2) fear of exercise induces weak exercise intention. CONCLUSION: The adherence of elderly frail lung cancer patients to exercise prehabilitation under telemedicine management is influenced by three interrelated factors: capability, opportunity, and motivation. Healthcare professionals should establish a three-pronged intervention approach of "assessment-training-support". They should strengthen patients' digital technology adaptation training, design exercise programs tailored to their symptoms, and build family group support networks. In addition, psychological interventions should be emphasized to enhance patients' willingness to participate in exercise prehabilitation. REGISTRATION NUMBER: ChiCTR2500101145.

From Intention to Action: A Grounded Theory Study on the Staged Mechanisms of Postoperative Exercise Behavior Among Breast Cancer Patients.

Shan L, Dai M, Li X … +5 more , Chen J, Yang J, You Y, Liu A, You T

Patient Prefer Adherence · 2026 · PMID 42124920 · Full text

BACKGROUND: Exercise is widely recommended for postoperative breast cancer patients due to its benefits for functional recovery and symptom management. However, real-world participation and long-term adherence remain con... BACKGROUND: Exercise is widely recommended for postoperative breast cancer patients due to its benefits for functional recovery and symptom management. However, real-world participation and long-term adherence remain consistently low. Existing research has largely focused on participation rates or perceived barriers, offering limited insight into the behavioral mechanisms that govern how exercise is initiated and sustained over time, particularly within specific cultural contexts. OBJECTIVE: To explore the mechanisms underlying the initiation and maintenance of postoperative exercise behaviors among breast cancer patients, with particular attention to the interaction among behavioral capability, motivation, and cues across different stages of recovery. METHODS: A qualitative study informed by grounded theory was conducted. Fifteen patients (n = 15) who had undergone unilateral mastectomy were purposively recruited from a tertiary hospital in Foshan, China. Semi-structured, in-depth interviews were carried out and analyzed using open, axial, and selective coding procedures. RESULTS: Postoperative exercise behavior was shaped by the dynamic interaction of three interrelated domains: capability, motivation, and cues. Capability-encompassing physical condition, exercise-related knowledge, and self-regulatory skills-functioned as a threshold condition for behavior initiation. Notably, the capability threshold evolved across the disease trajectory: in the early postoperative phase, it was primarily constrained by acute physical symptoms such as pain and limited mobility, whereas in the long-term recovery phase, it increasingly depended on patients' self-regulatory capacity and ability to integrate exercise into daily life.Motivation acted as a fluctuating driver influenced by perceived benefits, emotional responses, and external support. Cues, including professional guidance and family reminders, functioned as both behavioral triggers and a key maintenance mechanism. In the absence of sustained cues, behavioral discontinuity frequently occurred, even among patients with adequate motivation and capability.Cultural beliefs regarding rest and activity, rooted in the Chinese context, influenced patients' perceptions of exercise safety and timing, thereby shaping motivation and responsiveness to cues. CONCLUSION: Postoperative exercise behavior among breast cancer patients follows a staged mechanism characterized by capability-dependent initiation, motivation-driven fluctuation, and cue-dependent maintenance. These findings highlight the need for nurse-led, continuous, and context-sensitive interventions, rather than one-time education, to support long-term exercise adherence, particularly in cultural contexts where beliefs about rest and activity may shape patients' exercise behaviors. IMPLICATIONS FOR NURSING PRACTICE: Nursing interventions should move beyond information delivery and adopt a system-based behavioral support approach that strengthens exercise capability, by incorporating structured exercise prescriptions, continuous nurse-led follow-up, digital reminder systems, and family-supported cueing strategies into routine care.

Understanding Patients' Experiences and Adherence Challenges with Dietary and Fluid Restriction in End-Stage Kidney Disease: A Qualitative Study.

Liao Y, Lu C, Shuai Z … +3 more , Zhu Q, Zuo M, Liu L

Patient Prefer Adherence · 2026 · PMID 42116840 · Full text

PURPOSE: Dietary and fluid restrictions are essential for individuals with end-stage kidney disease across treatment modalities, including hemodialysis, peritoneal dialysis, and non-dialysis management. However, adherenc... PURPOSE: Dietary and fluid restrictions are essential for individuals with end-stage kidney disease across treatment modalities, including hemodialysis, peritoneal dialysis, and non-dialysis management. However, adherence to these restrictions remains suboptimal, and limited evidence exists regarding how individuals across different treatment stages interpret and manage these requirements in daily life. This study aimed to explore patients' lived experiences of dietary and fluid restrictions across these groups and to identify factors associated with adherence behaviors. METHODS: A descriptive qualitative study was conducted between April and May 2024 in China. Six focus group interviews were held with 40 individuals with ESKD, including 14 receiving hemodialysis, 14 undergoing peritoneal dialysis, and 12 managed without dialysis, aged 23-76 years. All interviews were audio-recorded, transcribed verbatim, and analyzed inductively using thematic analysis to identify key themes and subthemes. RESULTS: Six themes and 14 subthemes were identified and organized using the Health Belief Model: perceived susceptibility (interpreting the absence of symptoms as low risk, optimistic bias); perceived severity (experiencing physical discomfort and functional limitation, anticipating burden on family and daily life); perceived benefits (perceiving health and economic benefits, strengthening responsibility and sense of control); perceived barriers (experiencing psychological burden and behavioral conflict, navigating social and situational constraints, facing information complexity and uncertainty); self-efficacy (modifying daily dietary habits, emphasizing the role of self-discipline, using monitoring and adjustment strategies); and cues to action (responding to health deterioration as a turning point, drawing on multiple sources of support). CONCLUSION: Adherence to dietary and fluid restrictions in end-stage kidney disease is shaped by patients' interpretations of risk, embodied and social experiences, and negotiation of daily dietary demands. These processes occur within cultural and informational contexts where emotional burden, uncertainty, responsibility, and social support interact. Understanding these mechanisms may inform more patient-centred dietary care.

Application of the Gratitude Intervention in the Healthcare Field: Scoping Review.

Lin Z, Fang Y, Xiao W … +2 more , Yao M, Chen L

Patient Prefer Adherence · 2026 · PMID 42109705 · Full text

PURPOSE: To review the application of gratitude intervention measures in healthcare and to provide a reference for their clinical implementation and effective promotion. METHODS: A computerized search of PubMed, Web of S... PURPOSE: To review the application of gratitude intervention measures in healthcare and to provide a reference for their clinical implementation and effective promotion. METHODS: A computerized search of PubMed, Web of Science, Embase, CINAHL, and CNKI databases was performed, covering studies published up to January 2025. Relevant studies on the application of gratitude interventions in healthcare were screened, and the review was conducted using the Arksey and O'Malley scoping review framework and reported in accordance with the PRISMA-ScR guideline. RESULTS: A total of 34 studies were included in the analysis, covering three types of health issues: mental disorders or stress (50%), chronic diseases (26%), and tumors (24%). Gratitude interventions, primarily delivered by researchers and healthcare staff, include gratitude recording (76%), gratitude expression (50%), gratitude videos (6%), gratitude meditation (24%), gratitude sharing (15%), with gratitude recording and gratitude expression being the most commonly used. The application methods of gratitude interventions include online (n = 18, 53%), offline (n = 12, 35%), and a combination of both (n = 4, 12%). Although the study populations, intervention types, frequencies, durations, and evaluation methods varied across studies, gratitude interventions demonstrated varying degrees of improvement in patients' psychological status, physical health, quality of life, social support, interpersonal relationships, and other outcomes. CONCLUSION: A range of gratitude intervention strategies can be applied in healthcare settings to support mental and physical well-being. Gratitude recording and gratitude expression appear to be the most feasible options for routine practice, but the heterogeneity of the current evidence suggests that implementation should be tailored cautiously. Future research should focus on developing standardized intervention procedures, optimizing telemedicine-based delivery, and evaluating long-term effects.

Living Through Sweat: A Qualitative Study of the Pre-Surgical Decision-Making Trajectory in Patients with Palmar Hyperhidrosis.

Yan M, Chao S, Yu L … +8 more , Liu C, Li Z, Gong L, Bao B, You S, Zhang G, Ren Y, Du G

Patient Prefer Adherence · 2026 · PMID 42109704 · Full text

PURPOSE: This study aimed to explore the dynamic and ambivalent pre-surgical decision-making process of patients with palmar hyperhidrosis (PH), focusing on the "anxiety-sweating" feedback loop and the psychological fact... PURPOSE: This study aimed to explore the dynamic and ambivalent pre-surgical decision-making process of patients with palmar hyperhidrosis (PH), focusing on the "anxiety-sweating" feedback loop and the psychological factors influencing their treatment choices, particularly the interplay between psychological distress and the decision to pursue surgery. PATIENTS AND METHODS: We conducted a qualitative descriptive phenomenological study in accordance with the Consolidated Criteria for Reporting Qualitative Research (COREQ). Semi-structured in-depth interviews were conducted with 19 adults who had lived with PH for more than 10 years and were considering surgical treatment. All interviews were conducted before surgery. Data were analyzed using NVivo 11 software and Colaizzi's seven-step phenomenological method. RESULTS: Analysis revealed a four-stage pre-surgical journey. First, patients initially normalized excessive hand sweating as a personal difference or familial trait, but gradually developed disease awareness as symptoms persisted and intensified. Second, PH imposed a substantial psychosocial burden, including functional limitations in study, work, and daily life, as well as reduced self-confidence, anticipatory anxiety, and social avoidance. Many participants described a self-reinforcing "anxiety-sweating" vicious cycle. Third, dissatisfaction with conservative treatments and increasing access to treatment-related information prompted patients to move from temporary coping strategies toward consideration of more durable interventions. Fourth, surgical deliberation was characterized by ambivalence: patients hoped surgery would relieve symptoms and restore social confidence, while also expressing concerns regarding compensatory sweating, postoperative discomfort, and recovery. CONCLUSION: The pathway toward surgical consideration in patients with palmar hyperhidrosis was a dynamic and ambivalent process shaped by symptom normalization, psychosocial burden, prior treatment experiences, and concerns about surgical risks. These findings highlight the importance of addressing psychological and social experiences alongside technical counseling and support the value of shared decision-making in pre-surgical care.

Developing a Structured Framework for Pharmacist-Led Prescription Medication Counselling: A Scoping Review Integrating Structural Domains and Patient-Centered Operational Features.

Lee S, Han E, Jung Y

Patient Prefer Adherence · 2026 · PMID 42100025 · Full text

Medication counselling is a core element of pharmaceutical care that supports safe, rational, and adherent medication use. However, despite its importance, medication counselling remains suboptimally implemented in routi... Medication counselling is a core element of pharmaceutical care that supports safe, rational, and adherent medication use. However, despite its importance, medication counselling remains suboptimally implemented in routine practice. A clearer description of how counselling is structured in practice is therefore required. This study aimed not only to map existing practices but to develop a structured framework for pharmacist-led prescription medication counselling by integrating procedural components with patient-centered operational behaviors. The review followed the PRISMA Extension for Scoping Reviews checklist. MEDLINE, Embase, the Cochrane Library, and grey literature were searched for publications from January 2015 to January 2025. Fourteen sources, including both regulatory guidance documents and empirical studies, met the inclusion criteria. Using an adapted TIDieR framework, intervention components were deductively extracted and analyzed. Subsequently, content analysis was conducted to inductively synthesize them into structural domains and patient-centered operational features. Six structural domains were identified: patient identification and encounter framing; risk screening; information provision; understanding verification and engagement; adherence and self-management support; and documentation and referral or escalation. Four patient-centered operational features were also identified: patient context elicitation and prioritization; tailored communication adaptation; interactive understanding verification; and adherence support practices. Structural detail varied across sources, particularly for documentation and adherence-related elements.These operational features function as implementation-level elements within structural domains, linking procedural structure to observable patient-centered behaviors. This integrated framework conceptualizes medication counselling as an operationalized service and provides a foundation for its standardization, implementation, and evaluation in real-world practice.

Teaching Patients to Self-Care for Active, Recurrent Periodontal or Peri-Implant Pockets Guided by the TIME Wound-Healing Model: A Pilot Feasibility Study Based on Clinical and Microbiological Outcomes.

Miranda-Rius J, Àlvarez G, Blanc V … +3 more , León R, Ramírez-Rámiz A, Brunet-Llobet L

Patient Prefer Adherence · 2026 · PMID 42088931 · Full text

BACKGROUND: The TIME therapeutic model is used for the management of chronic wounds: Tissue (non-viable); Infection/Inflammation; Moisture (imbalance); Edges (non-advancing). These four components will determine the pers... BACKGROUND: The TIME therapeutic model is used for the management of chronic wounds: Tissue (non-viable); Infection/Inflammation; Moisture (imbalance); Edges (non-advancing). These four components will determine the persistence or the healing of any chronic ulcer on the skin's surface and, by analogy, also those of the ulcerated epithelium at the subgingival level. We aimed to evaluate the clinical and microbiological changes recorded after implementation of this personalized subgingival model. METHODS: Twelve patients with active periodontal or peri-implant pockets were recruited for a feasibility study. Patients were instructed to deeply clean these lesions subgingivally using an angulated interdental brush in a vertical position, twice per day for 15 days. On the first and last days, Löe & Silness gingival index and bleeding on probing (BoP) were recorded and samples were collected using the brush head for the quantitative PCR analysis of 8 bacterial species (commensal and pathogenic). RESULTS: Severe gingival inflammation with profuse bleeding was present at baseline in ten patients. Eight of them complied and adhered with 100% of the treatment. Following self-treatment at home, ten patients exhibited normal or mildly inflamed gums. Seven patients no longer had bleeding, four had slight bleeding and only one moderate bleeding. Microbiologically, the total bacterial load significantly decreased from 7E07 to 9.39E06 cfu/head. CONCLUSION: This proposed conservative cost-effective subgingival model could significantly improve the inflammatory activity of certain recurrent periodontal or peri-implant pockets, stabilize them and thus minimize their progression. The preliminary findings reflected a reduction or absence of bleeding, a relative decrease in pathogenic species, and the restoration of a microbial community in symbiosis with the host.

Person-Centered Approaches for Identifying Subgroups of Post-Stroke Depression: A Systematic Review of Observational Studies.

Shi D, Zhou M, Zou L

Patient Prefer Adherence · 2026 · PMID 42088930 · Full text

BACKGROUND: Current management for post-stroke depression (PSD) mainly relies on the severity of depression, insufficiently capturing PSD's clinical heterogeneity. No previous systematic review has jointly synthesized cr... BACKGROUND: Current management for post-stroke depression (PSD) mainly relies on the severity of depression, insufficiently capturing PSD's clinical heterogeneity. No previous systematic review has jointly synthesized cross-sectional and longitudinal observational studies using person-centered approaches to identify PSD subgroups. This systematic review synthesizes evidence from these studies employing person-centered approaches to characterize PSD subgroups. METHODS: Comprehensive searches were conducted in nine databases from the inception to September 2025. Observational studies using person-centered approaches to subgroup PSD were included. Two reviewers independently performed data extraction and study quality assessment using the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. RESULTS: Eleven articles (9 unique cohorts; N = 6729) were included. Cross-sectional studies (4 studies; N = 1400) identified four symptom-based subgroups: low depressive symptoms (46.6%), emotional depressive symptoms (9.4%), atypical depressive symptoms (23.2%), and widespread depressive symptoms (20.8%). Longitudinal studies (5 studies; N = 5329) revealed four trajectory-based subgroups: low and stable/decreasing (59.7%), low but increasing (17.8%), high and stable/increasing (13.6%), and initially high/moderate but declining (8.9%). Latent transition analysis (2 studies; N = 886) showed greater subgroup fluidity within 6-month post-stroke, followed by increasing stability. Predictors of more severe/persistent subgroups included social-demographic, clinical and physiological factors. One study found that all non-low-stable trajectories were associated with significantly increased 10-year mortality (hazard ratios: 1.38-2.62). CONCLUSION: Person-centered approaches can effectively delineate latent subgroups of PSD characterized by distinct symptom manifestations and trajectories. Findings of this review support a shift away from one-size-fits-all, total-score-based management toward a more nuanced, symptom- and trajectory-informed framework for PSD. SYSTEMATIC REVIEW REGISTRATION: CRD420251273568.

Determinants of Medication Non-Adherence in 1,750 Indonesian Adults with Chronic Diseases: A Nationwide Cross-Sectional Study.

Alfian SD, Griselda M, Hilmi IL … +3 more , Alshehri AA, Puspitasari IM, Abdulah R

Patient Prefer Adherence · 2026 · PMID 42080203 · Full text

PURPOSE: Medication adherence is critical for effective chronic disease management, yet non-adherence remains a major challenge. Current evidence on medication adherence in Indonesia is constrained by small sample sizes,... PURPOSE: Medication adherence is critical for effective chronic disease management, yet non-adherence remains a major challenge. Current evidence on medication adherence in Indonesia is constrained by small sample sizes, narrow geographic scope, and a failure to adequately account for the complex interplay of social, economic, and cultural factors. This study aimed to identify factors associated with medication non-adherence in patients with chronic diseases in Indonesia. METHODS: This nationwide cross-sectional study was carried out across 34 provinces in Indonesia during April - November 2024. Participants were patients aged 20-74 years diagnosed with at least one chronic disease. Medication non-adherence was assessed through an online and offline self-reported survey. Data was analyzed using multivariable logistic regression, with Odds Ratio (OR) and 95% Confidence Interval (CI) reported. RESULTS: Among 1,750 participants, 957 (54.7%) were adherent and 793 (45.3%) were non-adherent. Non-adherence was most prevalent in digestive diseases (371/541; 68.6%) and psychiatric disorders (37/52; 71.2%). In multivariable logistic regression, younger age (20-30 years: aOR 4.53, 95% CI 2.90-7.09), residence in Java and Bali (aOR 3.21, 95% CI 1.85-5.56), lower income (<IDR 1,500,000: aOR 2.08, 95% CI 1.48-2.92), absence of health insurance (aOR 1.43, 95% CI 1.06-1.92), self-perceived health status (healthy: aOR 2.48, 95% CI 1.63-3.77), and healthcare-seeking behavior (self-medication: aOR 3.36, 95% CI 2.37-4.77; no treatment: aOR 8.77, 95% CI 4.98-15.44) were significantly associated with non-adherence. CONCLUSION: Medication non-adherence affected nearly half of Indonesian patients with chronic diseases. Strengthening health insurance coverage, addressing financial and geographic disparities, and implementing targeted education strategies, including gender-sensitive approaches that address financial barriers among women and health perception-related factors among men, are essential to improve medication adherence.

Intertemporal Decision-Making Ability in Patients with Chronic Diseases: A Concept Analysis.

Li X, Lu Y, Xie W … +3 more , Zhang W, Zhang C, Zhou T

Patient Prefer Adherence · 2026 · PMID 42080202 · Full text

PURPOSE: Intertemporal decision-making ability influences adherence to health behavior and clinical outcomes in patients with chronic diseases. However, its concept remains insufficiently defined. This study aimed to ide... PURPOSE: Intertemporal decision-making ability influences adherence to health behavior and clinical outcomes in patients with chronic diseases. However, its concept remains insufficiently defined. This study aimed to identify the key attributes, antecedents, consequences, and empirical referents of intertemporal decision-making ability in patients with chronic diseases. METHODS: The Walker and Avant's concept analysis method was used. A systematic search for studies on intertemporal decision-making ability in patients with chronic diseases was conducted across the following databases: PubMed, Web of Science, CINAHL, Embase, PsycINFO, and the China National Knowledge Infrastructure (CNKI). The search covered literature from the beginning until January 2026. RESULTS: A total of 35 articles were included. Four defining attributes of intertemporal decision-making ability in patients with chronic diseases were identified: impulse control, emotional self-regulation, future health valuation, and future-oriented thinking and planning. Antecedents included economic factors, knowledge level, perceived health competence, disease status, emotional status, personality traits, and time perspective, while its consequences encompassed improved psychological status, adherence, and clinical outcomes. CONCLUSION: Intertemporal decision-making ability in patients with chronic diseases is a multidimensional psychological construct. A thorough examination of this concept can facilitate the development of appropriate assessment instruments and stratified interventions. In clinical practice, healthcare providers can deliver individualized interventions based on patients' specific deficient attributes, using strategies such as immediate rewards, environmental restructuring, health education, and episodic future thinking training to enhance intertemporal decision-making ability, thereby improving adherence to health behaviors and optimizing clinical outcomes.

Differences in Perspectives of Weight Management Among People in the US and Canada with Type 2 Diabetes by Body Mass Index.

Ross MM, Mulnick S, Boye KS … +5 more , Samuelson A, Thieu VT, Longuet C, Glass J, Hoog MM

Patient Prefer Adherence · 2026 · PMID 42080201 · Full text

PURPOSE: The link between type 2 diabetes (T2D) and obesity is well established; guidelines for treating T2D include recommendations to support healthy weight reduction. This study explored the perspectives of people in... PURPOSE: The link between type 2 diabetes (T2D) and obesity is well established; guidelines for treating T2D include recommendations to support healthy weight reduction. This study explored the perspectives of people in the US and Canada with T2D across BMI categories regarding the perceived value of reaching a lower weight and how this would impact their lives. PATIENTS AND METHODS: A quantitative cross-sectional survey informed by a targeted literature review and qualitative interviews was administered in English to adults in the US and Canada with T2D. Enrollment ensured a sample representative of the T2D population by BMI (per US census data). The survey explored weight management experience, impacts of T2D and weight on quality of life (QOL), and perceived value of 5%/10%/20% weight reductions. Results were summarized descriptively. Chi-squared tests and -tests assessed significant differences between BMI categories (p<0.05). RESULTS: The 746 participants had a mean (SD) BMI of 32.8 kg/m (8.2). Nearly all (93%) felt weight management was important to managing their T2D, regardless of BMI. Most (66%) reported currently thinking about and trying to lose weight at least multiple times each week over the last 2 years, especially those with higher BMIs (p<0.001). Higher BMI was also associated with more impacts of weight on T2D (emotional well-being, medical/health complications, physical/mobility limitations, sleep, daily activities, social and financial). Participants with higher BMIs desired greater weight reduction than those with lower BMIs when defining dream, achievable, acceptable and unsuccessful weight goals and were more likely to expect positive and meaningful impacts on their life with 5%/10%/20% weight reductions. CONCLUSION: Participants with T2D positively valued weight reduction and anticipate it to lead to improvements in their overall T2D management and QOL. As the percentage of weight reduction increased, those with higher BMIs perceived greater meaningfulness and more positive impacts.

Assessment of Patient Satisfaction with TB Care Services in Southern Afghanistan.

Stanikzai MH, Bariz H, Anwary Z … +3 more , Baray AH, Shirzad J, Dadras O

Patient Prefer Adherence · 2026 · PMID 42080200 · Full text

BACKGROUND: Patient satisfaction is an important measure of high-quality TB care. However, no study has investigated patient satisfaction with TB care services in Afghanistan. Therefore, this study aims to assess patient... BACKGROUND: Patient satisfaction is an important measure of high-quality TB care. However, no study has investigated patient satisfaction with TB care services in Afghanistan. Therefore, this study aims to assess patient satisfaction with TB care services in Southern Afghanistan. METHODS: Between October and December 2025, a cross-sectional study was carried out among adult TB patients, who were randomly selected from six TB care centers in Southern Afghanistan. The outcome variable was patient satisfaction, assessed by the Patient Satisfaction Questionnaire-18 (PSQ-18). Bivariate and multivariable logistic regression models were fitted to identify factors associated with patient dissatisfaction. RESULTS: Of 413 patients, 44.5% (95% CI: 39.6%-49.4%) were dissatisfied. The domains with the lowest satisfaction scores were financial aspects, followed by time spent with doctors. Patients living in rural areas (AOR = 1.72; 95% CI: 1.07-2.77), with lower household income (AOR = 1.73; 95% CI: 1.07-2.79), incurring out-of-pocket treatment costs (AOR = 1.68; 95% CI: 1.06-2.67), being in the continuation phase (AOR = 1.83; 95% CI: 1.12-2.98), not receiving counselling (AOR = 7.25; 95% CI: 3.86-13.61), and currently smoking (AOR = 2.05; 95% CI: 1.16-3.60) had greater odds of dissatisfaction with TB care. CONCLUSION: Nearly half of the TB patients were not satisfied with TB care. Policymakers and healthcare providers should address the determinants of dissatisfaction, particularly socioeconomic barriers, healthcare inequities, limited counselling, and regional disparities, to improve TB care programs in Southern Afghanistan.

iPREFER: Patients' Experiences and Preference of Treatment for Multiple Myeloma Following Multiple Lines of Treatment - A Qualitative Study.

Perry MB, Lochhead Devaraj R, Law K … +2 more , Ashby F, Taylor S

Patient Prefer Adherence · 2026 · PMID 42080199 · Full text

PURPOSE: Each year in the United Kingdom, approximately 6000 people are diagnosed with Multiple Myeloma (MM) and treated with targeted cancer drugs. The duration and frequency of these treatments vary and include oral, i... PURPOSE: Each year in the United Kingdom, approximately 6000 people are diagnosed with Multiple Myeloma (MM) and treated with targeted cancer drugs. The duration and frequency of these treatments vary and include oral, intravenous (IV), and subcutaneous administration. Patients often undergo multiple lines of treatment and live with uncertainty spanning years and decades. This study (ClinicalTrials.gov Identifier: NCT06322927) explores the experiences of people receiving treatment for MM, what matters most when making treatment decisions, and what influences their treatment preference. PATIENTS AND METHODS: This was a qualitative study using semi-structured interviews. Patients were eligible if they had a confirmed MM diagnosis and received at least five lines of treatment. Interviews focused on their extensive experiences of multiple lines of oral anti-cancer and bispecific antibody treatment, or IV therapy, and were analyzed using inductive thematic analysis. RESULTS: Four key themes were identified from nine interviews: "Living with MM and its impact on quality of life", portrays the relentless challenges and side effects of MM; "Factors influencing treatment decision making" outlines the importance of family, shared decision-making and information needs; "Factors influencing treatment experience", including practical challenges, and self-management; and "Treatment preference" explores participants' perceptions of treatment within the context of their own circumstances. Participants showed a willingness and tolerance to accept treatments that significantly impact their everyday life, quality of life, and relationships, to achieve their goals of care. CONCLUSION: The findings highlight the need for healthcare professionals to better understand individual patient circumstances and priorities, inform them of the treatment impact on their priorities to empower patients to choose the right treatment for them and improve quality of life. More research is needed to understand how to integrate this into the clinical care pathway.

Impact of Scrub Color on Patient Perceptions of Oral and Maxillofacial Surgeons: A Cross-Sectional Study.

Yurttutan ME, Kocamaz ÖF, Deniz B

Patient Prefer Adherence · 2026 · PMID 42080198 · Full text

PURPOSE: This study aims to evaluate how the use of five different colored scrubs by male and female surgeons in oral and maxillofacial surgery affects patients' perceptions of trust, experience, respect, cleanliness, an... PURPOSE: This study aims to evaluate how the use of five different colored scrubs by male and female surgeons in oral and maxillofacial surgery affects patients' perceptions of trust, experience, respect, cleanliness, and comfort. PATIENTS AND METHODS: A cross-sectional survey was completed by 500 adults attending a university OMS clinic. Participants viewed standardized photographs of one male and one female surgeon wearing scrubs in five colors: black, navy blue, green, red, and white. All non-attire factors were kept constant. Each image was rated on a five-point Likert scale for trustworthiness, experience, respectability, cleanliness, and comfort. Group differences were analyzed using Chi-square and Kruskal-Wallis tests, followed by Bonferroni-adjusted post-hoc comparisons. RESULTS: Scrub color showed significant associations with all evaluated traits (p < 0.001). Green, black, and navy blue received the highest ratings across most dimensions, while red consistently ranked lowest. Demographic factors produced only minor variations, and post-hoc results revealed little difference among the three best-rated colors. CONCLUSION: Scrub color contributes to how patients perceive OMS surgeons, particularly in a field where anxiety is already common. Darker, traditional tones may support more reassuring impressions, while red appears less favorable. These findings may help guide attire preferences and institutional dress policies.

Treatment-Related Factors for Medication Non-Adherence Among Patients with Major Depressive Disorder: An Explanatory Sequential Mixed-Methods Study.

Riaz S, Khuda F, Jan A … +5 more , Nasim A, Khalil AAK, Albabtain BA, Büyüker SM, Ullah A

Patient Prefer Adherence · 2026 · PMID 42080197 · Full text

PURPOSE: This study aimed to examine treatment-related factors influencing antidepressant non-adherence among patients with Major depressive disorder in Pakistan. METHODS: An explanatory sequential mixed-methods cross-se... PURPOSE: This study aimed to examine treatment-related factors influencing antidepressant non-adherence among patients with Major depressive disorder in Pakistan. METHODS: An explanatory sequential mixed-methods cross-sectional design was employed. The study first conducted questionnaire-based quantitative research to assess non-adherence and its treatment-related predictors. This was followed by semi-structured interviews with a purposively selected subset of participants who were poorly adherent to explore their contextual experiences. Quantitative and qualitative findings were integrated using narrative synthesis and joint displays. RESULTS: A total of 2,513 participants with recurrent major depressive disorder (MDD) were surveyed. Among them, 812 (32.3%) were classified as poorly adherent, 719 (28.6%) as moderately adherent, and 982 (39.1%) as highly adherent, based on the UMGLS-4. High ADR burden, low DAI-10 scores, unemployment, low income, and age above 55 years were significantly associated with non-adherence (p <0.05). Participants with high ADR burden were 1.42 times more likely to be non-adherent (AOR = 1.42, p < 0.001). Qualitative findings from 17 interviews supported and expanded these associations, revealing how sedation, weight gain, cultural interpretations of medication as "hot", lack of treatment timelines, and poor pharmacy support discouraged routine antidepressant use. CONCLUSION: A combination of physiological, cognitive, and systemic treatment-related barriers drives antidepressant non-adherence among Pakistani MDD patients. Addressing these factors through culturally sensitive ADR counselling, consistent follow-up, and pharmacist-led support may improve adherence and treatment outcomes in low-resource mental health settings.

Disparities in Knowledge, Attitudes, and Practices Regarding Rheumatoid Arthritis Between Han and She Ethnic Groups in Ningde City, Eastern Fujian, China: A Cross-Sectional Study.

Chen S, Chen S, Chen H … +6 more , Zhou Y, Chen Y, Chen S, Chen J, Guo J, Chen P

Patient Prefer Adherence · 2026 · PMID 42064539 · Full text

BACKGROUND: Rheumatoid arthritis (RA) poses significant health challenges worldwide. However, little is known about disparities in knowledge, attitudes, and practices (KAP) regarding RA among ethnic minorities in China.... BACKGROUND: Rheumatoid arthritis (RA) poses significant health challenges worldwide. However, little is known about disparities in knowledge, attitudes, and practices (KAP) regarding RA among ethnic minorities in China. This study aimed to compare KAP outcomes between Han and She ethnic groups and to explore the influencing factors. METHODS: A cross-sectional study was conducted among residents of Ningde City, Fujian Province, China, between June 2023 and January 2024. RESULTS: A total of 546 valid questionnaires were collected. The mean knowledge, attitude, and practice scores for the total sample were 8.85±5.85, 41.10±6.56, and 16.47±3.91, respectively. Han participants exhibited significantly higher attitude (44.02±6.49 vs. 40.46±6.40, P<0.001) and practice scores (17.41±4.15 vs. 16.25±3.82, P=0.005) than She participants, although knowledge scores were slightly lower among Han (7.85±3.60 vs. 9.06±6.21, P=0.119), although this difference was not statistically significant (P = 0.119). Structural equation modeling analysis revealed that education was positively associated with knowledge (β = 1.53, P < 0.001), while knowledge (β = 0.40, P < 0.001) and ethnicity (β = 4.04, P < 0.001) showed direct paths to attitudes. Furthermore, attitudes (β = 0.25, P < 0.001) and income (β = 0.64, P < 0.001) were independently associated with practices. CONCLUSION: Residents in Ningde City demonstrated generally adequate knowledge and positive attitudes towards RA but only moderate levels of proactive practices. Ethnic disparities were observed, with Han participants showing better attitudes and practices than She participants. Targeted educational interventions that consider ethnic and socioeconomic differences are warranted to enhance RA management outcomes in minority communities.

Prioritisation of Factors Influencing Outpatient Satisfaction in Chinese Public Hospitals: A Dominance Analysis.

Liu W, Li G, Ding K … +7 more , Wang S, Fan Z, Wang Z, Zhuang Q, Liu Y, Liu L, Li L

Patient Prefer Adherence · 2026 · PMID 42064538 · Full text

OBJECTIVE: To investigate the current status of outpatient satisfaction with their healthcare experience and its influencing factors, providing a basis for improving medical service quality. METHODS: Utilizing data from... OBJECTIVE: To investigate the current status of outpatient satisfaction with their healthcare experience and its influencing factors, providing a basis for improving medical service quality. METHODS: Utilizing data from a 2021-2024 national survey by Doctor-Patient Experience Research Base, National Health Commission of the people's Republic of China across 20 hospitals (n=49,371 outpatients), this study analyzed the impact of hospital characteristics, patient demographics, and care process factors (registration time, consultation time, payment time, waiting time, perceived value of consultation) on satisfaction. Chi-square tests and Logistic regression identified significant factors; the innovative application of dominance analysis was then used to assess their relative importance contribution and establish a clear priority for intervention. RESULTS: Hospital characteristics, care process factors, and most patient demographics showed significant associations with satisfaction (p<0.05). Logistic regression identified consultation time, perceived value of consultation, payment time, registration time, and waiting time as significant predictors of satisfaction (p<0.001). The dominance analysis revealed a distinct hierarchy of influence: consultation time had the highest relative contribution to satisfaction, followed by perceived value of consultation, payment time, registration time, and waiting time. CONCLUSION: This study analyses the key sequences for enhancing patient satisfaction and healthcare experience, providing healthcare managers with precise actionable guidance.

Evidence Summary for Self-Management Education in Patients with Non-Alcoholic Fatty Liver Disease.

Yang Y, Cao J, Zhang L … +2 more , Liu J, Li M

Patient Prefer Adherence · 2026 · PMID 42058452 · Full text

PURPOSE: To systematically summarize domestic and international evidence on self-management education for patients with non-alcoholic fatty liver disease (NAFLD), and to provide an evidence base for nurses to deliver hea... PURPOSE: To systematically summarize domestic and international evidence on self-management education for patients with non-alcoholic fatty liver disease (NAFLD), and to provide an evidence base for nurses to deliver health education and guide patient self-management. PATIENTS AND METHODS: The evidence summary adhered to the standards issued by the Fudan University Center for Evidence-based Nursing.Guided by the "6s" evidence pyramid, a top-down search was conducted of evidence related to self-management education in patients with NAFLD. Sources included clinical decision-support tools, guidelines, best practice documents, systematic reviews, evidence summaries, expert consensus statements and randomized controlled trials. The following databases and resources were systematically searched: BMJ Best Practice, Up To Date, PubMed, Web of Science, the Cochrane Library, CINAHL, CNKI, the Wanfang Database and relevant guideline websites. The search period covered the time from the beginning of the database up to August 2025. RESULTS: 19 articles met the inclusion criteria, comprising 6 guidelines, 4 systematic reviews, 5 expert consensus statements, 2 randomized controlled trials and 2 evidence summaries. Thirty pieces of evidence were generated in five domains: (1) disease monitoring and assessment; (2) weight and nutritional management; (3) exercise and physical activity management; (4) self-monitoring and health education; and (5) social support systems. Most evidence was of moderate-to-high quality and showed good consistency. CONCLUSION: The synthesized evidence on self-management education for patients with NAFLD provides a reference for clinical practice. It can support nurses in developing scientific, individualized self-management education plans according to patients' characteristics, thereby improving the quality of long-term disease management and health outcomes.
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