Patient Preference And Adherence[JOURNAL]
Sun
200 papers
Changes in Dyadic Coping and Health Behaviors Across Pregnancy in Gestational Hypertension: A Three-Wave Dyadic Cross-Lagged Actor-Partner Interdependence Model Study.
Yu SH, Chen GH, Sheng XM … +4 more , Li RL, Wang CL, Liang XH, Gan XN
Patient Prefer Adherence · 2026 · PMID 42051930 · Full text
OBJECTIVE: Based on the Actor-Partner Interdependence Model, this study longitudinally explores the dynamic interactions between dyadic coping and health behaviors among patients with gestational hypertension and their s...
OBJECTIVE: Based on the Actor-Partner Interdependence Model, this study longitudinally explores the dynamic interactions between dyadic coping and health behaviors among patients with gestational hypertension and their spouses, providing a basis for promoting health behaviors in both partners. METHODS: Using the convenience sampling method, 260 cases of patients with gestational hypertension were selected. Dyadic Coping Inventory (DCI) and the Health Promoting Lifestyle Profile (HPLP) were used to conduct investigations at 20-21 weeks of gestation (T1), 28 weeks of gestation (T2), and 36 weeks of gestation (T3). RESULTS: The actor effects of dyadic coping between patients with gestational hypertension and their spouses on health behaviors were significant. That is, the dyadic coping of both patients (T1→T2: β = 0.11, T2→T3: β = 0.10, all p < 0.01) and spouses (T1→T2: β = 0.09, T2→T3: β = 0.08, all p < 0.01) could be positively and prospectively associated with their own health behaviors at the next time point. The actor effects of health behaviors of patients and spouses on dyadic coping were also significant. Specifically, the health behaviors of both patients (T1→T2: β = 0.14, T2→T3: β = 0.11, all p < 0.001) and spouses (T1→T2: β = 0.12, P < 0.001; T2→T3: β = 0.10, p < 0.01) could be positively and prospectively associated with their own dyadic coping at the next time point. Furthermore, significant partner effects of health behaviors were found: the health behaviors of both patients (T1→T2: β = 0.13, T2→T3: β = 0.12, all p < 0.001) and spouses (T1→T2: β = 0.09, T2→T3: β = 0.07, all p < 0.01) could be positively and prospectively associated with the other's health behaviors at the next time point. CONCLUSION: Dyadic coping and health behaviors interact between patients with gestational hypertension and their spouses.
5G Bedside Interactive Terminal Health Education to Enhance Treatment Adherence in Elderly Patients with Chronic Diseases: The Mediating Role of Self-Efficacy.
Zhang S, Ruan X
Patient Prefer Adherence · 2026 · PMID 42051929 · Full text
OBJECTIVE: To evaluate the acceptance of 5G-enabled bedside interactive terminal health education among elderly patients with chronic diseases and analyze its impact on treatment adherence, focusing on the mediating role...
OBJECTIVE: To evaluate the acceptance of 5G-enabled bedside interactive terminal health education among elderly patients with chronic diseases and analyze its impact on treatment adherence, focusing on the mediating role of self-efficacy. METHODS: A cross-sectional survey was conducted with 294 elderly inpatients with chronic diseases (January 2022-January 2023). Acceptance was measured using a technology acceptance model (TAM)-based Health Education Acceptance Scale, self-efficacy with the Chronic Disease Self-Efficacy Scale (CDSES), and adherence via the 5-item Medication Adherence Report Scale, Exercise Adherence Rating Scale, and self-developed Dietary Adherence Scale. Hierarchical linear regression was constructed to analyze the impact of acceptance on adherence, controlling for demographics/clinical variables. The mediating effect of self-efficacy was examined by Bootstrap testing. RESULTS: Participants reported moderately high acceptance (TAM_score: 64.29 ± 17.26) and moderate self-efficacy (CDSES score: 6.95 ± 1.97). Adherence scores were 19.99 ± 3.22 (medication), 16.29 ± 4.30 (exercise), and 27.93 ± 5.73 (diet). Acceptance was significantly associated with all adherence domains (all < 0.001). Self-efficacy partially mediated the effects on medication (indirect effect = 0.0159, : 0.0075-0.0252) and exercise adherence (indirect effect = 0.0218, : 0.0098-0.0360). Among TAM dimensions, perceived usefulness most stably predicted adherence, independently and positively influencing exercise adherence (B = 0.212, 95% CI: 0.062-0.361, = 0.006). CONCLUSION: 5G terminal-based health education was significantly associated with better treatment adherence among elderly patients with chronic diseases. Self-efficacy serves as a crucial mediator, particularly for medication and exercise behaviors. Optimizing terminal interactivity and enhancing self-efficacy are crucial for improving long-term disease management outcomes.
Demand Analysis of Mobile Health Applications for Patients with Chronic Kidney Disease Across Different E-Health Literacy Levels.
Gao Y, Pu LJ, Yan Y … +6 more , Duan DF, Liu M, Yan LJ, Li L, Ma DY, Chen Y
Patient Prefer Adherence · 2026 · PMID 42040174 · Full text
PURPOSE: Chronic kidney disease (CKD) requires innovative strategies to support long-term self-management. This study is novel in applying the Kano model to examine preferences for mobile health (mHealth) apps among Chin...
PURPOSE: Chronic kidney disease (CKD) requires innovative strategies to support long-term self-management. This study is novel in applying the Kano model to examine preferences for mobile health (mHealth) apps among Chinese patients with CKD and to compare these preferences across different levels of e-health literacy. PATIENTS AND METHODS: A multicenter cross-sectional survey was conducted among 484 patients with CKD in China. Face-to-face questionnaires were used to assess self-management needs and user interface (UI) preferences for CKD-related mHealth apps. App attributes were classified using the Kano model, and their priorities were further evaluated using Better-Worse coefficients and ranking analysis. RESULTS: Low e-health literacy users prioritized foundational features: must-be attributes included disease knowledge, while one-dimensional attributes were symptom and medication management. High e-literacy users emphasized medical insurance information (must-be) and disease management (one-dimensional). Both groups valued an intuitive UI, in addition to considering privacy protection as must-be attributes, low e-health literacy users required simplified navigation, whereas high e-health literacy users preferred efficient data entry. CONCLUSION: Preferences for CKD mHealth apps varied by e-health literacy level. Patients with lower e-health literacy may benefit more from basic health education and simplified interfaces, whereas those with higher e-health literacy expect more advanced and efficient functionalities. These findings highlight the value of the Kano model in identifying differentiated user needs and can inform the development of tailored mHealth apps to support equitable CKD self-management.
Preoperative Educational Video Viewing is Associated with a Reduced Incidence of Subconjunctival Hemorrhage Following Intravitreal Anti-VEGF Injection.
Cai H, Xu J, He J … +10 more , Sui A, Zhang P, Tang Y, Ding J, Hua P, Zheng W, Su M, Ye P, Fang X, Zheng F
Patient Prefer Adherence · 2026 · PMID 42027608 · Full text
OBJECTIVE: To assess whether preoperative viewing of an educational procedural video reduces the incidence and severity of subconjunctival hemorrhage (SCH) following intravitreal anti-VEGF injections (IVI), and improves...
OBJECTIVE: To assess whether preoperative viewing of an educational procedural video reduces the incidence and severity of subconjunctival hemorrhage (SCH) following intravitreal anti-VEGF injections (IVI), and improves patient experience. METHODS: In this surgeon-blind randomized controlled trial conducted at a single tertiary care center (NCT07002372), treatment-naïve patients scheduled for their first IVI were prospectively enrolled and randomized to either an intervention group (video viewing) or a control group (no video viewing). All participants completed the State-Trait Anxiety Inventory-State (STAI-S) before and after the injection. SCH incidence and area were assessed via standardized post-injection photographs analyzed using ImageJ software. Additional outcomes included patient-reported pain scores, heart rate, procedure time, and surgeon-rated cooperation. RESULTS: A total of 108 patients were enrolled, of whom 103 completed the study, which was fewer than the initially planned sample size. Baseline demographics were similar between groups. SCH occurred in 21/51 (41.2%) patients in the intervention group versus 36/52 (69.2%) in the control group ( = 0.004), though SCH area did not differ significantly. Logistic regression analysis revealed that the use of anticoagulant medication was positively associated with the occurrence of SCH (OR = 3.252; 95% CI, 1.166-9.071; = 0.024), whereas watching an educational video prior to IVI was associated with a lower risk of SCH (OR = 0.275; 95% CI, 0.115-0.656; = 0.004). Anxiety scores decreased post-procedure in both groups. In the intervention group, anxiety decreased modestly after video viewing (28.54 ± 10.40 to 27.00 ± 8.78, = 0.052). Patients rated the video as helpful for understanding (8.75/10), calming nerves (8.44/10), and improving cooperation (8.55/10). No significant differences were observed in pain scores, heart rate, procedure time, or surgeon-rated cooperation. CONCLUSION: Preoperative procedural video viewing reduces the incidence of SCH and improves patients' understanding of IVI. Given its simplicity and ease of implementation, this approach may serve as a practical adjunct to enhance patient experience in clinical practice.
A Network Analysis of Social Integration and Subjective Well-Being in Young and Middle-Aged Lymphoma Patients.
Zhang L, Wu Y, Zhang Y … +2 more , Xu C, Zhu W
Patient Prefer Adherence · 2026 · PMID 42027607 · Full text
OBJECTIVE: To explore the network relationships between social integration and subjective well-being (SWB) and to identify key nodes within this network among young and middle-aged lymphoma patients. METHODS: This study...
OBJECTIVE: To explore the network relationships between social integration and subjective well-being (SWB) and to identify key nodes within this network among young and middle-aged lymphoma patients. METHODS: This study was conducted at a tertiary cancer hospital in Urumqi, Xinjiang, China. From February to November 2025, a total of 315 young and middle-aged lymphoma patients were recruited using convenience sampling. Data were collected via a general information questionnaire, the Social Cohesion Scale, and the General Well-Being Schedule. We used network analysis to identify core and bridge nodes in the social integration and SWB network. A network comparison test (NCT) was performed to examine potential gender differences. RESULTS: The network analysis revealed that "Daily integration" demonstrated the strongest edge weight with "Relaxed or tense". In terms of node centrality, "Depressed or happy mood" and "Daily integration" emerged as the core nodes with the highest strength centrality, while "Daily integration" and "Intimate integration" were identified as the pivotal bridge nodes connecting different network clusters. No gender differences were observed in the association network between social integration and SWB. CONCLUSION: This study explores the network associations between social integration and SWB in young and middle-aged lymphoma patients. The findings suggest that intervention strategies may focus on improving emotional regulation, daily social interaction, and intimate relationships to enhance social integration and SWB in this population. Given the heterogeneity in clinical characteristics among lymphoma patients, future studies are warranted to validate the present findings across different subtypes and treatment backgrounds.
Patient Priorities for Coverage of New Antihypertensive Drugs: A Discrete Choice Experiment in China.
Chen J, Pan C, Wang G … +5 more , Qian L, Lu Y, Xie T, Gu J, Geng J
Patient Prefer Adherence · 2026 · PMID 42022155 · Full text
OBJECTIVE: Hypertension is a chronic condition in which patient-centered decisions are crucial for long-term adherence and outcomes. We aimed to obtain patient priorities for health insurance coverage of new antihyperten...
OBJECTIVE: Hypertension is a chronic condition in which patient-centered decisions are crucial for long-term adherence and outcomes. We aimed to obtain patient priorities for health insurance coverage of new antihypertensive drugs, and translate these preferences into reimbursement proposals using a discrete choice experiment. METHODS: A systematic literature review and semi-structured interviews were conducted to determine the attributes and levels. A Bayesian D-efficient design with blocking techniques was used to generate choice scenarios in the experiment. We conducted one-on-one, face-to-face interviews with patients with hypertension across four provinces in China. A mixed logit model was used to estimate patient preferences, marginal willingness-to-pay, and preference heterogeneity. RESULTS: Data analysis included 802 patients. When prioritizing new antihypertensives for health insurance coverage, patients placed more importance on improvement in health-related quality of life (HRQoL), followed by lower out-of-pocket costs per year, systolic blood pressure (SBP) control, fewer common side effects, and decreased five-year mortality due to cardiovascular diseases. Patients were willing to pay CNY 4049 (95% CI 3418-4681) annually for significant improvements in HRQoL. Patients with higher untreated office SBP prioritized effective SBP control and the lowest five-year stroke risk. CONCLUSION: Hypertensive patients primarily prefer improved HRQoL, lower out-of-pocket costs, and favorable long-term health outcomes. Our findings support preference-responsive reimbursement mechanisms, such as tiered coverage based on patient-valued outcomes and risk-stratified subsidies for patients at high cardiovascular disease risk.
Evidence-Based Contraceptive Guidance for Young Women Following Induced Abortion: A Systematic Summary.
Tu L, Wu H, Chen S … +4 more , Wu Y, Yan H, Mei B, Xiao Y
Patient Prefer Adherence · 2026 · PMID 42022154 · Full text
OBJECTIVE: To summarize the best available evidence on post-abortion contraceptive counseling for young women (aged 15-24 years) and provide an evidence-based basis for clinical practice. METHODS: Following the "6S" mode...
OBJECTIVE: To summarize the best available evidence on post-abortion contraceptive counseling for young women (aged 15-24 years) and provide an evidence-based basis for clinical practice. METHODS: Following the "6S" model, we systematically searched international and Chinese guide websites, professional association websites, and databases in both Chinese and English, from inception to June 2025. The types of literature included clinical decisions, evidence summaries, guidelines, and expert consensus. Two researchers independently performed literature screening, data extraction, and quality assessment. Guidelines were assessed by AGREE II, systematic reviews by AMSTAR 2.0, and RCTs and expert consensus by JBI critical appraisal tools. Evidence was graded using the JBI Evidence Grading System (2014) and synthesized by topic. RESULTS: Fifteen articles were included the following: 3 clinical decision aids, 7 guidelines, 2 expert consensus statements, 2 systematic reviews, and 1 RCT. Thirty-three pieces of evidence were summarized across seven categories: provision of contraceptive services, timing of initiation, assessment and counseling, values clarification, complications and management, follow-up, and support. CONCLUSION: This summary provides contraceptive guidance for young women after induced abortion. Healthcare providers should integrate local policies and personal preferences, follow patient-centered principles, and translate this evidence into practice to increase uptake of efficient contraceptive methods and reduce unintended pregnancies among young women. SYSTEMATIC REVIEW REGISTRATION: Fudan University Center for Evidence-Based Nursing (Registration No. ES20257666).
Factors Influencing Dietary Supplement Selection Among Older Adults in Iran: A Discrete Choice Experiment.
Valaei Sharif F, Rahimi F, Zeraat M … +2 more , Fathi Y, Sharif Z
Patient Prefer Adherence · 2026 · PMID 42016037 · Full text
INTRODUCTION: Understanding factors that shape dietary supplement choices among older adults is important for guiding healthcare, industry, and policy. This study aimed to identify key factors influencing supplement choi...
INTRODUCTION: Understanding factors that shape dietary supplement choices among older adults is important for guiding healthcare, industry, and policy. This study aimed to identify key factors influencing supplement choices among older adults using a discrete choice experiment (DCE). METHODS: This study recruited 384 participants aged ≥65 years (mean age 73.7, 52% women) from pharmacies in Tehran and Karaj. Attributes were developed through literature review and expert consultation and analyzed using a DCE with multinomial logit model. RESULTS: Participants had a mean age of 73.67 years; 52% were women. Physician recommendation emerged as the most influential factor, followed by supplement form, monthly cost, ingredient composition, and country of manufacture. Higher costs significantly reduced selection likelihood, vitamin-mineral products were preferred over herbal-only supplements, and foreign-licensed products were favored over domestic ones. Socioeconomic and demographic variables showed no significant effects. DISCUSSION: These findings highlight the dominant role of healthcare provider influence and cost sensitivity, along with perceptions of formulation quality and origin. Results can support professionals, manufacturers, and policymakers in developing supplement strategies tailored to older adults' needs and expectations.
Perceived Barriers and Supports to Medication Adherence in Type 2 Diabetes: A Qualitative Study of Patients with and without a Zero-Dollar Copay Health Plan Benefit.
Winberg D, Panchang SV, Nauman E … +6 more , Mohundro BL, Tang T, Price-Haywood EG, Onufrak S, Shi L, Bazzano AN
Patient Prefer Adherence · 2026 · PMID 42016036 · Full text
INTRODUCTION: Medication adherence among individuals with type 2 diabetes (T2D) remains a critical determinant of disease management and health outcomes. While cost-sharing reductions such as a $0 copay (ZDC) for drugs a...
INTRODUCTION: Medication adherence among individuals with type 2 diabetes (T2D) remains a critical determinant of disease management and health outcomes. While cost-sharing reductions such as a $0 copay (ZDC) for drugs are used to improve adherence, less is known about how patients with and without such benefits perceive barriers to adherence and what strategies may further support consistent medication use. This study explored barriers and facilitators to medication adherence among health plan members with T2D, including perceived barriers and potential strategies to enhance medication adherence. METHODS: This qualitative study was conducted as part of a larger mixed-methods investigation examining medication adherence among individuals with T2D. The research team conducted semi-structured interviews with health plan members diagnosed with T2D. An interview guide was co-developed by a multidisciplinary team that included health services researchers, patients, health plan leaders, and clinicians, ensuring relevance and clarity across stakeholder groups. Interviews were conducted between June and December 2024, audio-recorded with participant consent, and transcribed verbatim. A descriptive qualitative analysis was conducted using both inductive and deductive approaches. Three members of the research team independently applied open coding techniques to the transcripts, iteratively refining themes through discussion and consensus. NVivo software was used to facilitate data organization and analysis. RESULTS: In total, we interviewed 21 Louisiana Blue, a reginal health insurance plan, beneficiaries (11 with the ZDC benefit and 10 without the ZDC benefit). We identified four themes from the interviews - themes were the same across the two groups - 1) Costly medication copays were described as a key barrier to taking medications as prescribed; 2) memory aids, family support, and routines were identified as strategies to maintain adherence; 3) health care providers were crucial in educating members about their medication, including responding to concerns such as side effects; and 4) members' perceptions of pharmaceutical companies were coupled with concerns about medication costs. Barriers and facilitators were largely similar among participants with and without the zero-dollar copay benefit. CONCLUSION: Findings suggest that eliminating copayments alone does not resolve the multifaceted barriers to adherence, and that limited awareness of benefit status may further constrain the impact of such programs; introduction.
Development and Validation of a Multidimensional Scale to Assess Cancer Health Education Outcomes in Patients.
Yong P, Wang T
Patient Prefer Adherence · 2026 · PMID 42011366 · Full text
BACKGROUND: Effective cancer health education enhances patients' understanding, emotional regulation, and treatment compliance. However, validated instruments specific to educational outcomes remain limited. These items...
BACKGROUND: Effective cancer health education enhances patients' understanding, emotional regulation, and treatment compliance. However, validated instruments specific to educational outcomes remain limited. These items reflect the proximal effects of education and are not meant to represent generic mental health states. OBJECTIVE: To develop and validate a multidimensional scale to assess the effects of cancer health education, including a clear distinction of the outcomes as proximal educational results. METHODS: Following ethical approval, a cross-sectional study was conducted among 236 adult cancer patients recruited at the Third Affiliated Hospital of Chongqing Medical University, Chongqing, China, from 06 January 2025 to 21 March 2025. Item generation was informed by the Health Belief Model, patient interviews, and expert review. The 13-item scale was administered via self-report questionnaire. Internal consistency was evaluated using Cronbach's alpha, and construct validity was assessed through exploratory factor analysis (EFA). RESULTS: EFA revealed a three-factor structure-Health Knowledge Comprehension, Emotional-Attitudinal Support, and Health Behavior Implementation-that explained 60.07% of the total variance. This suggests the multidimensional nature of cancer health education outcomes. The scale demonstrated excellent internal consistency (α =0.902), with all subscale alphas exceeding 0.80. Factor loadings ranged from 0.72 to 0.89, indicating strong item-factor relationships. CONCLUSION: The Cancer Health Education Scale is a multidimensional instrument with preliminary psychometric support for evaluating educational outcomes in cancer care. Further validation in diverse populations is required. The scale may provide a useful foundation for tailoring patient education programs and supporting future cross-cultural validation studies.
Development and Preliminary Validation of a Dyadic Psychoeducational Intervention for Hemodialysis Patients and Caregivers Based on the Double ABC-X Model.
Zhang L, Zhang X, Tang W … +3 more , Zou L, Chen Y, Zhou L
Patient Prefer Adherence · 2026 · PMID 42004624 · Full text
OBJECTIVE: To develop and preliminarily validate a dyadic psychoeducational intervention program for maintenance hemodialysis (MHD) patients and their caregivers based on the Double ABC-X Model. METHODS: The intervention...
OBJECTIVE: To develop and preliminarily validate a dyadic psychoeducational intervention program for maintenance hemodialysis (MHD) patients and their caregivers based on the Double ABC-X Model. METHODS: The intervention was constructed by integrating evidence from systematic reviews, cross-sectional survey data (200 MHD patient-caregiver dyads), and a two-round Delphi expert consultation (20 experts). The program, grounded in the Double ABC-X Model, comprised four core modules: (1) disease information provision, (2) social support enhancement, (3) coping strategy training, and (4) relaxation techniques. A pilot trial with three dyads was conducted to assess feasibility and refine the program. Effectiveness was not evaluated in this developmental study. RESULTS: The intervention was designed as a 4-week program with one 30-40 minute session per week, delivered in face-to-face small groups during pre- or post-dialysis periods. It comprises 4 first-level, 22 second-level, and 10 third-level indicators, organized into four themes: "First Acquaintance", "Deep Understanding", "Co - Solution" and "Co - Experience". Delphi results showed high expert authority (Cr=0.85-0.86), significant Kendall's concordance coefficient (P<0.001), importance scores ≥4.35 (5-point scale), and low variation coefficients (≤0.12), indicating strong consensus. CONCLUSION: This study developed a theory-driven, content-validated dyadic psychoeducational intervention for MHD patient-caregiver dyads. Future multicenter randomized controlled trials are needed to validate long-term efficacy.
Development and Preliminary Psychometric Evaluation of the Glycogen Storage Disease Type Ia Functional Assessment Diary (GSD FAD).
Turner-Bowker DM, Egan S, Butler J … +5 more , Jewett A, Mitragotri D, Foster B, Skrinar A, Theodore-Oklota C
Patient Prefer Adherence · 2026 · PMID 42004623 · Full text
PURPOSE: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive condition with deficiency of glucose-6-phosphatase (G6Pase) characterized by fasting hypoglycemia due to an inability to release...
PURPOSE: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive condition with deficiency of glucose-6-phosphatase (G6Pase) characterized by fasting hypoglycemia due to an inability to release glucose from hepatic glycogen stores and other metabolic pathways, requiring frequent consumption of exogenous glucose for survival. Patient-reported outcome (PRO) measures are important to assess GSDIa burden, though no disease-specific PRO for GSDIa exists. This research describes the Glycogen Storage Disease Functional Assessment Diary (GSD FAD), a 31-item PRO developed to assess the signs/symptoms and impacts of GSDIa in individuals ages 8 and older. PATIENTS AND METHODS: Mixed methods research including a literature review, online survey, and concept elicitation (CE) interviews informed the construction of the GSD FAD. Cognitive debriefing (CD) interviews evaluated concept relevance and understanding of the questionnaire. Psychometric properties were evaluated using Phase 3 trial screening/baseline data to assess item variability, structure/scaling potential, scoring, reliability, validity, and minimum detectable change. RESULTS: The literature review, online survey (N=26), and CE interviews (N=7) identified hypoglycemia and cornstarch regimen impacts as most burdensome and most important to treat from the patient perspective. The initial draft GSD FAD included 36 items. Most items were interpreted as intended in CD interviews (N=16); revisions to the GSD FAD addressed interpretation issues. Three domain scores (Symptoms Total Score, Sleep Impacts Total Score, and Daily Impacts Total Score) showed acceptable reliability and validity but had notable ceiling effects that may limit responsiveness in some settings. CONCLUSION: The GSD FAD is a novel, content-valid PRO that measures the humanistic burden of GSDIa and cornstarch treatment regimen, including the signs/symptoms of hypoglycemia and their impact on health-related quality of life (HRQoL) in individuals ≥ 8 years with GSDIa, that yields reliable and valid scores. While developed in a trial setting, the GSD FAD has potential for use in nutritional, behavioral, and/or educational applications.
Bidirectional Longitudinal Associations Among Health-Related Quality of Life, Emotional Expressivity, and Readiness to Return to Work in Patients with Non-Muscle-Invasive Bladder Cancer Receiving Intravesical Therapy: A Three-Wave Cohort Study.
Zhang M, Zhou Y
Patient Prefer Adherence · 2026 · PMID 41983101 · Full text
PURPOSE: We aimed to elucidate the temporal relationship among health-related quality of life(HRQoL), emotional expressivity, and readiness for return to work(RRTW) in patients with non-muscle-invasive bladder cancer rec...
PURPOSE: We aimed to elucidate the temporal relationship among health-related quality of life(HRQoL), emotional expressivity, and readiness for return to work(RRTW) in patients with non-muscle-invasive bladder cancer receiving intravesical therapy. DESIGN: A three-wave cohort study. METHODS: In this prospective observational study, we recruited 425 patients from two tertiary hospitals between August 2022 and January 2024. Three waves of self-reported questionnaires were administered at the start of at the start of intravesical therapy (T1, N=412), at six months (T2, N=309), and at twelve months (T3, N=227). The main analysis was based on data from patients who completed all three waves of the assessment. We constructed cross-lagged panel models to examine the temporal associations among HRQoL, emotional expressivity, and RRTW. RESULTS: A total of 227 patients completed all three waves of assessment. Controlling for covariates such as intravesical therapy medication, age, gender, economic income, and marital status, the results indicated a longitudinal relationship between HRQoL at T1 and T2 and emotional expressivity and RRTW at T2 and T3. Emotional expressivity at T1 and T2 was positively associated with HRQoL and RRTW at T2 and T3. HRQoL and emotional expressivity were mutually reinforcing relationships. RRTW at T1 and T2 was positively associated with HRQoL at T2 and T3; however, this positive association disappeared after emotional expressivity was added. Mediation analyses revealed that HRQoL at T1 was positively associated with RRTW at T3 through emotional expressivity at T2 (standardized indirect effect=0.020, 95% bootstrap CI [0.005, 0.035]). CONCLUSION: These results demonstrated that HRQoL and emotional expressivity mutually reinforced effect relationships, and both could facilitate RRTW among non-muscle-invasive bladder cancer receiving intravesical therapy. As an observational study, these findings identify potential targets for intervention but require confirmation in experimental designs.
Dietary Management Experiences and Educational Needs of Patients in the Recovery Phase of Pancreatitis: A Descriptive Phenomenological Study.
Kuang L, Jiang S, Liu X … +2 more , Xiong T, Luo X
Patient Prefer Adherence · 2026 · PMID 41983100 · Full text
PURPOSE: To explore dietary management experiences and nursing education needs among patients in the recovery phase of pancreatitis from the patient perspective, and to provide evidence to inform the development of feasi...
PURPOSE: To explore dietary management experiences and nursing education needs among patients in the recovery phase of pancreatitis from the patient perspective, and to provide evidence to inform the development of feasible, individualized, and continuous dietary management strategies. PATIENTS AND METHODS: A descriptive phenomenological qualitative design was adopted. Purposive sampling was used to recruit 15 patients in the recovery phase of pancreatitis who were treated in the hepatobiliary surgery department of a tertiary hospital in Chongqing, China, from June to September 2025. Semi-structured, in-depth interviews were conducted. Data were analyzed using thematic analysis. RESULTS: Four major themes were identified: (1) perceptions of the relationship between diet and disease; (2) limited access to dietary information and insufficient content; (3) challenges encountered during dietary management; and (4) specific needs regarding the content and delivery formats of dietary education. CONCLUSION: Although patients in the recovery phase of pancreatitis recognize the importance of dietary control, the lack of specific, actionable guidance and ongoing support substantially limits long-term adherence to a low-fat diet. Clinical nurses should move beyond one-time, principle-based education and provide structured, staged, and individualized dietary guidance. Integrating digital health tools to support continuous follow-up may enhance patients' dietary self-management, promote recovery, and reduce the risk of disease recurrence.
Qualitative Assessment of Experiences and Challenges Faced by Mothers of Children Using an Insulin Pump in the United Arab Emirates.
Abdul Fattah L, Eldeeb NM, Farajallah A … +2 more , Shankar PR, Palaian S
Patient Prefer Adherence · 2026 · PMID 41983099 · Full text
BACKGROUND: Various benefits and challenges influence insulin pump use by diabetic patients, especially children. Mothers, as the primary caregivers, can provide valuable feedback on their children's health-related issue...
BACKGROUND: Various benefits and challenges influence insulin pump use by diabetic patients, especially children. Mothers, as the primary caregivers, can provide valuable feedback on their children's health-related issues. This study aimed to explore the experiences and challenges faced by mothers of children using an insulin pump. METHODS: This qualitative exploratory research involved in-depth interviews of eight mothers in the United Arab Emirates selected purposively during March 2025, whose children had type 1 diabetes and used an insulin pump up to the age of 12 years old. A validated interview guide was used. RESULTS: The use of an insulin pump positively impacted the mothers' and children's quality of life. The main identified themes were mothers' knowledge and perception of insulin pump use, the impact of insulin pump use clinically, psychologically, and socially, the challenges faced, and recommendations. All participants preferred the use of an insulin pump due to its positive properties. Yet, mothers mentioned some concerns, including sudden device malfunction, wrong placement of the cannula, financial burden and the lack of awareness of the needs of insulin pump users. CONCLUSION: Insulin pump therapy has significant advantages and disadvantages, but in the opinion of the mothers interviewed, the advantages outweigh the drawbacks.
Controlling Symptoms versus Minimizing Negative Treatment Impact: A Grounded Theory Study of Heterogeneity in Patient Preferences for Psoriasis Treatments.
Szabo SM, Hawkins NS, Germeni E
Patient Prefer Adherence · 2026 · PMID 41978741 · Full text
PURPOSE: Patients vary in preferences for health outcomes, risks, and treatments. However, heterogeneity in patient preferences is not typically considered in health technology assessment (HTA) decision-making. Using pla...
PURPOSE: Patients vary in preferences for health outcomes, risks, and treatments. However, heterogeneity in patient preferences is not typically considered in health technology assessment (HTA) decision-making. Using plaque psoriasis as a case study, we aimed to provide an in-depth understanding of how preferences are shaped and explore real-world preference heterogeneity subgroups for psoriasis treatments. PATIENTS AND METHODS: In this grounded theory study, 38 Canadians with moderate-to-severe psoriasis engaged in one-to-one, semi-structured interviews between October 2023 and December 2024. Theoretical sampling was guided by treatment history, and data collection and analysis occurred in parallel. Data were coded in NVIVO using the constant comparison technique. Themes were developed iteratively, and a conceptual model was developed to illustrate how treatment priorities, personal and contextual factors shape preferences for specific psoriasis therapeutic modalities. RESULTS: Participant ages ranged from 25 to 66 years; 24 were female, 19 were currently experiencing moderate-to-severe symptoms and 16 had received injectable biologics. We identified that treatment priorities could be grouped under two headings: control of psoriasis symptoms and minimization of negative treatment impact. All participants valued treatment effectiveness, while preferences for other treatment aspects varied. Prioritizing symptom control was also driven by social and emotional factors (such as avoiding stigma and embarrassment, or impact on daily activities) and the need to control multiple comorbid conditions. Those prioritizing the minimization of negative treatment impact often valued treatments that were convenient or easy to take, avoiding "unnecessary" medical treatment, and avoiding adverse events and dependence. Similar underlying preference drivers could result in different reported preferences. While wanting a "convenient" treatment was common, some considered a daily pill ideal and others a monthly injection; according to what fitted best into their current lifestyle. While acceptance of their chronic health condition was a commonly discussed theme, some operationalized this as preferences for more intensive treatments (minimizing psoriasis impact), versus less intensive regimens (minimizing treatment burden). Some participants reported being unable to afford co-payments for treatments they would prefer to take. Preferences varied according to age, psoriasis severity, life stage and treatment experience. CONCLUSION: Heterogeneity in patient preferences for aspects of psoriasis impact and treatment translate into a range of different preferences for specific psoriasis therapies. These findings support considering preference heterogeneity in expanding decision-making frameworks to ensure patient voices are considered within HTA.
Postoperative Oropharyngeal Muscle Training Compliance in Obstructive Sleep Apnea: Growth Mixture Model.
Zhao XM, Zhao WG
Patient Prefer Adherence · 2026 · PMID 41969522 · Full text
PURPOSE: To explore developmental trajectories of oropharyngeal muscle training adherence and their influencing factors in postoperative adult patients with obstructive sleep apnea (OSA). PATIENTS AND METHODS: This study...
PURPOSE: To explore developmental trajectories of oropharyngeal muscle training adherence and their influencing factors in postoperative adult patients with obstructive sleep apnea (OSA). PATIENTS AND METHODS: This study was a prospective longitudinal observational study. Using convenience sampling, adult OSA patients who were hospitalized and underwent surgery at the First Affiliated Hospital of University of Science and Technology of China from October 2023 to January 2025 were selected as the study subjects. A total of 215 patients were enrolled, with 11 lost to follow-up during the postoperative periods of 4 weeks, 8 weeks, and 12 weeks, resulting in a final analysis sample size of 204 cases. Using the General Information Questionnaire, Oropharyngeal Muscle Training Adherence Questionnaire, Self-Management Questionnaire for Adult Obstructive Sleep Apnea Patients, General Self-Efficacy Scale, and Epworth Sleepiness Scale, patients' oropharyngeal muscle training adherence levels were assessed at 1 week, 4 weeks, 8 weeks, and 12 weeks after adult OSA surgery. A latent variable growth mixture model was applied to identify adherence development trajectories, and multivariate logistic regression analysis was used to examine the influencing factors of different trajectory categories. RESULTS: Three oropharyngeal muscle training adherence development trajectories were identified in adult OSA patients post-surgery: the Low-start Sustained Increase Group, the Moderate Gradual Decline Group, and the Moderate Rapid Decline Group. Multivariate logistic regression analysis identified self-management scores and GSES as significant independent predictors of trajectory group membership, with ESS also showing predictive value for certain trajectory comparisons (p < 0.05). CONCLUSION: There is significant heterogeneity in postoperative oropharyngeal muscle training (OMT) adherence trajectories among adult OSA patients. Identifying these distinct patterns enables the stratification of patients for tailored interventions. Healthcare providers should prioritize individuals showing declining adherence for early, targeted support.
Combined IKAP-Based Continuity Care and Bundle Care in Patients Undergoing Cerebrovascular Interventional Surgery: A Retrospective Study.
Shen L, Jia W, Mei X … +1 more , Lyu J
Patient Prefer Adherence · 2026 · PMID 41969521 · Full text
BACKGROUND: Cerebrovascular interventional surgery requires comprehensive postoperative care for long-term recovery. While bundle care standardizes acute management, it often lacks structured post-discharge support. This...
BACKGROUND: Cerebrovascular interventional surgery requires comprehensive postoperative care for long-term recovery. While bundle care standardizes acute management, it often lacks structured post-discharge support. This study evaluated the added benefit of combining Information-Knowledge-Attitude-Practice (IKAP) theory-based continuity care with bundle care. METHODS: A retrospective comparative study was conducted on 88 patients treated between April 2022 and April 2024. Based on the standard care protocol at admission, patients were non-randomly assigned to a control group (n = 44, receiving bundle care) or an observation group (n = 44, receiving bundle care plus a 3-month IKAP-based continuity care program). The IKAP program included structured WeChat-based education, bi-weekly behavioral coaching, and family support. Outcomes assessed at baseline and 3 months included disease knowledge awareness rate, psychological resilience (Connor-Davidson Resilience Scale, CD-RISC), activities of daily living (Barthel Index, BI), sleep quality (Pittsburgh Sleep Quality Index, PSQI), self-management ability, and patient satisfaction. Analysis of covariance (ANCOVA) was used to compare post-intervention scores between groups, adjusting for baseline values. RESULTS: Baseline characteristics were comparable between groups (all P > 0.05). At 3 months, the observation group showed a significantly higher disease knowledge awareness rate (93.2% vs. 77.3%, χ= 4.423, P = 0.035). After adjusting for baseline scores, the observation group also demonstrated significantly greater improvements in psychological resilience (all CD-RISC subscales, P < 0.001), BI score (adjusted mean: 86.8 vs. 73.9, P < 0.001), PSQI score (8.2 vs. 9.8, P = 0.004), and all domains of self-management (all P < 0.001, with large effect sizes Cohen's d: 1.07-2.18). Overall patient satisfaction was higher in the observation group (90.9% vs. 70.5%, P = 0.020). CONCLUSION: Integrating IKAP-based continuity care with bundle care was associated with better short-term recovery outcomes compared to bundle care alone after cerebrovascular intervention. This model warrants prospective validation.
Patient Preferences in Hidradenitis Suppurativa Depend on Treatment Experience: Results from APProach-HS.
Kromer C, Faverio K, Görig T … +9 more , Schneider-Burrus S, Benzel F, Goebeler M, Presser D, Schummer P, Schaarschmidt ML, Harth W, Mössner R, Peitsch WK
Patient Prefer Adherence · 2026 · PMID 41953329 · Full text
PURPOSE: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with significant unmet therapeutic needs. However, information on patient preferences for HS therapies is hitherto scarce. Our aim was to inve...
PURPOSE: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with significant unmet therapeutic needs. However, information on patient preferences for HS therapies is hitherto scarce. Our aim was to investigate the impact of treatment experience on patient preferences for pharmacological and surgical treatment of HS using conjoint analysis. PATIENTS AND METHODS: Discrete choice experiments were applied for the attributes treatment modality (tablets, subcutaneous injections, surgery with secondary intention healing or primary closure), probability of sustained therapeutic success, probability of mild or severe adverse events, and duration of treatment or wound healing. These attributes were subsequently correlated with treatment experience. RESULTS: Overall, 216 patients with HS considered therapeutic success as most important (Relative Importance Score (RIS):36.2), followed by the treatment modality (RIS:24.0). Patients experienced with biologics favoured subcutaneous injections most (PWU:18.1 vs. -0.5, p=0.020), whereas biologic-naïve patients preferred tablets. Patients who had undergone surgery with secondary intention healing valued this approach (PWU:4.1 vs. -24.8, p=0.004) and therapeutic success (RIS:37.5 vs. 31.6, p=0.017) higher and the duration of wound healing lower (RIS:18.9 vs. 23.3, p=0.037) than others. CONCLUSION: Individual preferences were depending significantly on treatment experience. Incorporation of this aspect could help to improve personalized care of patients with HS.
"You Can Lead a Horse to Water, but You Can't Make It Drink". Gastroenterology Healthcare Professionals' Perceptions of Reasons for Patient Non-Adherence to Inflammatory Bowel Disease Prescribed Medication: A Qualitative Study.
King K, Norton C, Jammeh A … +2 more , Chalder T, Czuber-Dochan W
Patient Prefer Adherence · 2026 · PMID 41953328 · Full text
PURPOSE: Inflammatory bowel disease (IBD) is commonly treated with medications to induce and maintain remission. Yet many patients do not take treatments as prescribed. Understanding healthcare professionals' (HCPs) beli...
PURPOSE: Inflammatory bowel disease (IBD) is commonly treated with medications to induce and maintain remission. Yet many patients do not take treatments as prescribed. Understanding healthcare professionals' (HCPs) beliefs about medication non-adherence may help clarify whether their views align with patients' experiences and inform future adherence support strategies. PATIENTS AND METHODS: Semi-structured interviews were conducted with 21 purposively selected HCPs from diverse professional backgrounds working within gastroenterology in the National Health Service (publicly funded healthcare system in the United Kingdom). Interviews were video recorded, transcribed verbatim, and analyzed using Braun and Clarke's principles of reflective thematic data analysis. RESULTS: Four main themes were identified: 1) HCPs' perceptions of patients' adherence, including perceived reasons for adherence and non-adherence, honesty about adherence, sub-group differences, and the language used in consultations. 2) how HCPs seek to promote adherence through empathy, reassurance, provision of information, practical tools, support strategies, and treatment decisions aligned with patients' needs. 3) challenges for supporting adherence, including everyday practice barriers, systemic constraints, and reflections on whether HCPs themselves may contribute to the problem. 4) what is needed to improve adherence, encompassing support for patients, HCPs, and healthcare systems, as well as proposed intervention approaches. CONCLUSION: HCPs recognize that adherence in IBD is shaped by multiple determinants, many of which can be influenced through clinical practice and patient interactions. Strategies such as empathy, reassurance, clear communication, reliable information, medication-taking tips, are believed to support adherence whilst providing safe practice. However, challenges arise from patient-, professional-, and system-level factors. Addressing these requires shared responsibility between clinician and patient, adequate consultation time, improved service capacity and sustained person-centered care. Flexible and timely training for HCPs may also enhance adherence support. Capturing HCPs' perspectives offers valuable insight into medication adherence in IBD and can inform strategies to strengthen adherence support within clinical care.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe