Revista Medico-chirurgicala A Societatii De Medici Si Naturalisti Din Iasi[JOURNAL]
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200 papers
CORTICOSTEROID TREATMENT IN THE SETTING OF DECOMPENSATED LIVER CIRRHOSIS WITH RELATIVE ADRENAL INSUFFICIENCY: A CASE REPORT AND A BRIEF REVIEW OF THE LITERATURE.
Chiriac S, Stanciu C, Trifan A
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483706
Relative adrenal insufficiency (RAI) is the term used to describe inadequate production or action of glucocorticoids with respect to the severity of the illness. RAI is frequently found in critically ill patients particu...
Relative adrenal insufficiency (RAI) is the term used to describe inadequate production or action of glucocorticoids with respect to the severity of the illness. RAI is frequently found in critically ill patients particularly with septic complications and it is also present in both critically ill and stable patients with liver cirrhosis. In the following study a case report of a patient with decompensated cirrhosis and RAI is presented followed by a brief review of the literature. A 65-year-old male with liver cirrhosis of alcoholic etiology was admitted to hospital with bilateral leg edema, ascites, and marked weakness. At admission, his blood pressure was 82/52 mmHg and he had sinus tachycardia of 130/min. Laboratory analysis revealed hyponatremia (122 mmol/L), while ascites fluid analysis showed no infection. During the first 48 hours of hospitalization the patient remained persistently hypotensive despite adequate vascular filling and the addition of noradrenaline. A standard-dose short synacthen test was performed which revealed a poor cortisol response, which is a compatible criterion for the diagnosis of RAI. Intravenous hydrocortisone therapy was initiated, which resulted in a rapid improvement in patient's general condition, and increase in blood pressure. As the patient became hemodynamically stable without the need of noradrenaline, the hydrocortisone dose was weaned progressively, and he was discharged after 18 days of hospitalization in a stable condition.
EXTRADIGESTIVE MANIFESTATIONS OF GASTROESOPHAGEAL REFLUX DISEASE: DEMOGRAPHIC, CLINICAL, BIOLOGICAL AND ENDOSCOPIC FEATURES.
Bărboi OB, Prelipcean CC, Mihai C … +5 more , Floria M, Chirilă I, Darie AM, Drug VL, Bălan G
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483705
UNLABELLED: Gastroesophageal reflux disease (GERD) with extradigestive manifestations is a disorder increasingly recognized both by gastroenterologists, pneumologists, otolaryngologists and cardiologists. AIM: To evaluat...
UNLABELLED: Gastroesophageal reflux disease (GERD) with extradigestive manifestations is a disorder increasingly recognized both by gastroenterologists, pneumologists, otolaryngologists and cardiologists. AIM: To evaluate the demographical, clinical, biological and endoscopic features of the patients with gastroesophageal reflux disease and extradigestive manifestations (chronic laryngitis, asthma, pseudoangina). MATERIAL AND METHODS: Prospective case-control study, including 137 patients selected from patients referred to the Iasi Institute of Gastroenterology and Hepatology between July 2014-September 2015. In the presence of typical GERD symptoms (heartburn or regurgitation), the patients were assessed by upper digestive endoscopy for the detection or exclusion of esophagitis. Despite the absence of esophageal lesions, the patients were further assessed by impedance-pHmetry. RESULTS: Depending on the dominant extradigestive manifestation, the patients were assigned into 3 groups: 94 chronic laryngitis patients, 24 asthma patients and 19 pseudoangina patients. Females were more frequent among pseudoangina patients (68.4%). Mean age of the male patients with dysphonia or asthma was lower (p=0.002), the majority (78.1%) living in urban areas. Obesity was predominant in pseudoangina group (52.6%), as compared to dysphonia group (16%) the differences being statistically significant (p=0.002). A share of 57.9% of pseudoangina patients were dyslipidemic, in contrast to dysphonia (24.5%) or asthma group (37.5%) (p=0.013). Esophagitis was also more frequent at pseudoangina group (84.2%), but with no significant statistical difference between the study groups (79.8% and 75%, respectively) (p=0.115). It seems that Helicobacterpylori infection tends to be protective in patients with GERD and pseudoangina (RR=0.61), but it can not be extrapolated to the general population (p=0.459). CONCLUSION: GERD with extradigestive manifestations is a prevalent and heterogeneous disease. There are demographic, clinical, biological and endoscopic differences between patiens with extradigestive GERD.
ANATOMICAL AND CLINICAL ORBSERVATIONS ON STRUCTURAL CHANGES OF THE HIP JOINT.
Macovei LA, Rezus E
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483704
UNLABELLED: The hip, the second largest joint of the human body, with its primary contribution to locomotion, is exposed to numerous traumatic or non-traumatic risks. Regardless of the initial pathology, there is always...
UNLABELLED: The hip, the second largest joint of the human body, with its primary contribution to locomotion, is exposed to numerous traumatic or non-traumatic risks. Regardless of the initial pathology, there is always almost the same result: diminution of range of motion, onset of pain and functional impotence, as well as change of biomechanics of walking. Through its high frequency, morpho-functional imbalance (clinically expressed both imagistic and biologically, in one or several joints), osteoarthritis is a disease with a multifactorial etiology and a complex pathogeny. MATERIAL AND METHOD: The study included 244 patients aged between 18-85 years, clinically and paraclinically investigated, especially for the osteoarthritis of the hip, admitted to Rheumatology Clinic I, Rehabilitation Hospital in Iasi, from January 2012 to December 2014. RESULTS AND DISCUSSION: The high prevalence of degenerative diseases of the joints in old age is analyzed in accordance with the results of the estimations, which showed that, in fact, most of the patients remain undetected, undiagnosed and untreated. Main symptoms are pain in the coxofemoral joint, radiating or not on the lateral or anterior face of the thigh down to the knee, morning stiffness after a long rest, limping or walking with small steps, and muscle atrophy of the group of muscles that are responsible for the stability of the joint. CONCLUSIONS: A strict discipline is needed from the patient's side, in order to keep and apply the doctor's indications in a chronic disease that requires a long therapy, on one hand; on the other hand, a close cooperation between various experts is needed, in order to customize and apply the most effective program, at the right time.
MEDICAL PRACTICE IN CHILDREN PRESENTING FEVER WITH PETECHIAL RASH TO AN EMERGENCY DEPARTMENT.
Dumitrascu-Biris I, Chirita-Emandi A, Lambert I … +2 more , Marginean O, Sharif F
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483703
INTRODUCTION: The association of fever and petechiae in children is one of the most alarming findings for a paediatrician. To quickly distinguish between benign and life-threatening conditions is challenging in many case...
INTRODUCTION: The association of fever and petechiae in children is one of the most alarming findings for a paediatrician. To quickly distinguish between benign and life-threatening conditions is challenging in many cases. We aimed to evaluate the clinical practice of children presenting with fever and petechiae as initial symptoms. METHODS: 41 patients (age 3 months-11 years) presenting with fever and petechiae were identified in an Emergency Paediatric Assessment Unit over a period of 9 months. General data, symptoms and signs were assessed for each patient. The work-up consisted in: complete blood count, inflammatory tests, coagulation tests, Monospot test, nasopharyngeal rapid tests, blood culture, and cerebrospinal fluid culture where appropriate. RESULTS: Most children were <5 years of age (70.7%). Female to male ratio was 1:2.4. The most common clinical diagnoses were: viral respiratory illness (48.8%, 20/41) and upper respiratory tract infection (17.1%, 7/41). Meningococcal disease was found in one case. CRP>6 mg/l was poorly correlated with serious illness. The following variables were strongly associated with serious illness: ill appearance, shivering, lethargy, back rigidity, ESR>50 mm/h and prolonged capillary refill time. 59% (24/41) of children were treated with antibiotics, however, at discharge 42%(10/24) of them, did not have a work-up suggestive for a bacterial illness. CONCLUSIONS: Screening for low prevalence but high morbidity conditions, as the meningococcal disease, with an extensive work-up is time and resource consuming and may lead to unmotivated antibiotic use. Larger studies are needed to change the emergency practice for management of fever and rash.
TREATMENT OF METABOLIC ALTERATIONS IN POLYCYSTIC OVARY SYNDROME.
Păvăleanu I, Gafiţanu D, Popovici D … +2 more , Duceac LD, Păvăleanu M
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483702
Polycystic ovary syndrome is a common endocrinopathy characterized by oligo ovulation or anovulation, signs of androgen excess and multiple small ovarian cysts. It includes various metabolic abnormalities: insulin resist...
Polycystic ovary syndrome is a common endocrinopathy characterized by oligo ovulation or anovulation, signs of androgen excess and multiple small ovarian cysts. It includes various metabolic abnormalities: insulin resistance, hyperinsulinemia, impaired glucose tolerance, visceral obesity, inflammation and endothelial dysfunction, hypertension and dyslipidemia. All these metabolic abnormalities have long-term implications. Treatment should be individualized and must not address a single sign or symptom. Studies are still needed to determine the benefits and the associated risks of the medication now available to practitioners.
POTENTIAL NEW ROLES OF LEPTIN IN HEALTH AND DISEASE.
Florescu A, Bîlha S, Buţa C … +5 more , Vulpoi C, Preda C, Ristescu I, Grigoraş I, Brănişteanu DD
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483701
Leptin is an adipose-tissue specific cytokine described 20 years ago and classically thought to be involved in regulation of food intake and energy homeostasis. More recently, leptin was proven to exert other multiple ro...
Leptin is an adipose-tissue specific cytokine described 20 years ago and classically thought to be involved in regulation of food intake and energy homeostasis. More recently, leptin was proven to exert other multiple roles in carbohydrate and lipid metabolism, reproductive system, and inflammatory and immune reactions. Emerging data propose leptin to be a modulator of bone mass. In some particular circumstances leptin synthesis follow specific patterns in inflammation and sepsis, not being proportional with fat mass. Therefore, it may be used as diagnostic or prognostic marker for critical illness.
MUSCULOSKELETAL IMPAIRMENT IN PRYMARY HYPOTHYROIDISM.
Radu L, Groppa L, Vudu L
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483700
This article contains bibliographical data concerning the rheumatic clinical manifestations in hypothyroidism: polyarthralgias, lack of recent skill of fine movements of the hands, carpal tunnel syndrome or tarsal, degen...
This article contains bibliographical data concerning the rheumatic clinical manifestations in hypothyroidism: polyarthralgias, lack of recent skill of fine movements of the hands, carpal tunnel syndrome or tarsal, degenerative arthropathy or acute type (gout, chondrocalcinosis), adhesive capsulitis (frozen shoulder syndrome), generalized muscular stiffness, hypothyroid myopathy, secondary osteoarthritis, Dupuytren's contracture, "trigger finger" (also called as stenosing tenosynovitis or trigger thumb) etc. and data on the short history, epidemiology, of these disorders. Review include 60 bibliographical sources.
INFLUENCE OF SLEEP ON OBESITY IN CHILDREN.
Anton-Paduraru DT, Teslariu O, Mocanu V
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483699
Childhood obesity is a global epidemic with long term implications. The main cause of obesity is an increase in calorie intake and a decrease in physical activity, but also there is clear evidence suggesting a link betwe...
Childhood obesity is a global epidemic with long term implications. The main cause of obesity is an increase in calorie intake and a decrease in physical activity, but also there is clear evidence suggesting a link between the duration and quality of sleep and obesity risk. Good sleep habits are involved in increased ability to concentrate at school, improvement of general state, immune system development, increased quality of life. On the other hand, there are several mechanisms by which chronic sleep deprivation induces weight gain: disturbance of hormones that control hunger center, increased time for meals, reduced physical activity, metabolic changes. Recently, nighttime sleep duration has declined, in contrast with the increasing prevalence of obesity. Childhood sleep habits have a long term effect on weight, with repercussions even into adulthood. This is the reason why there is increasing interest to include sleep quality on the list for childhood obesity prevention. Sleep represents an important and independent risk factor of obesity in children and adolescents and it should be taken into consideration in the management of obesity.
SCORING IN ACUTE PANCREATITIS: WHEN IMAGING IS APPROPRIATE?
Cucuteanu B, Prelipcean CC, Mihai C … +2 more , Dranga M, Negru D
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483698
Acute pancreatitis (AP) is a frequent presentation to the emergency departments with a rising incidence and a great variability in clinical severity and outcome. The aim of this review is to offer a succinct presentation...
Acute pancreatitis (AP) is a frequent presentation to the emergency departments with a rising incidence and a great variability in clinical severity and outcome. The aim of this review is to offer a succinct presentation on acute pancreatitis scoring systems and the use of different imaging methods in severity prediction: Ranson criteria, Glasgow criteria, Hong Kong Score, Acute Physiology and Chronic Health Evaluation II (APACHE II), computed tomography scoring systems, Bedside Index of Severity in Acute Pancreatitis (BISAP) score, Panc 3, Japanese Severity Score (JSS), Harmless Acute Pancreatitis Score (HAPS), Pancreatitis Outcome Prediction (POP), Sequential Organ Failure Assessment (SOFA). This article also describes the Revised Atlanta Classification of AP (2012) and the correlation with computed tomography.
NEW CLASS OF DRUGS: THERAPEUTIC RNAi INHIBITION OF PCSK9 AS A SPECIFIC LDL-C LOWERING THERAPY.
Strat AL, Ghiciuc CM, Lupuşoru CE … +1 more , Mitu F
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483697
Hyperlipidemia is a well-known risk factor for coronary heart disease, the leading cause of death for both men and women. Current lipid-lowering treatment is not always efficient, therefore new pharmacological interventi...
Hyperlipidemia is a well-known risk factor for coronary heart disease, the leading cause of death for both men and women. Current lipid-lowering treatment is not always efficient, therefore new pharmacological interventions that reduce LDL cholesterol (LDL-C) have been developed. This paper presents new class of specific LDL lipid-lowering drugs under investigation in phase II or III clinical trials. The inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), a key enzyme in cholesterol homeostasis, improve the liver's ability to clear LDL from the plasma, reducing LDL-C levels. Currently, three monoclonal antibodies PCSK9 inhibitors (alirocumab, evolocumab and bococizumab) are evaluated in clinical outcome trials. ALN-PCSsc, the new first-in- class therapeutic RNA interference (RNAi) inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) is also the first-in-class investigational medicine that acts by turning off PCSK9 synthesis in the liver. The development leadership of ALN-PCSsc has now transferred from Alnylam Pharmaceuticals to The Medicines Company, who has initiated the ORION-1 Phase II study at the beginning of 2016. ALN-PCSsc has significant potential given its highly competitive profile as compared with monoclonal antibodies anti-PCSK9 MAbs, a recently approved class of LDL-C lowering drugs.
EATING BEHAVIOR IN RESPONSE TO ACUTE STRESS.
Mocanu V, Bontea A, Anton-Păduraru DT
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483696
Obesity is a medical and social problem with a dramatically increasing prevalence. It is important to take action since childhood to prevent and treat obesity and metabolic syndrome. Infantile obesity affects all body sy...
Obesity is a medical and social problem with a dramatically increasing prevalence. It is important to take action since childhood to prevent and treat obesity and metabolic syndrome. Infantile obesity affects all body systems starting in childhood and continuing to adulthood. Understanding the impact of stressors on weight status may be especially important for preventing obesity. The relationship between stress, eating behavior and obesity is not fully understood. However, there is evidence that stress causes disorders in hypothalamic-pituitary-adrenal (HPA) axis, system that regulates both stress and feeding responses. Also, the response is different depending on the type of stressors. Chronic stress, especially when people live in a palatable food environment, induces HPA stimulation, excess glucocorticoids, insulin resistance, which lead to inhibition of lipid mobilization, accumulation of triglyceride and retention of abdominal fat.
ADVANCEMENT REGARDING THE ROLE OF ENDOTHELIUM IN ARTERIAL WALL DYSFUNCTION.
Serban DN, Serban IL
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 27483695
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Antioxidant Activity of Essential Oil From Carum Carvi L. Cultivated in North-Eastern Romania.
Trifan A, Aprotosoaie AC, Cioancă O … +4 more , Hăcianu M, Jităreanu A, Gille E, Miron A
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30152663
Essential oils have significant antioxidant activity, being used frequently as preservatives in the food and cosmetic industries. Aim: To assess the in vitro antioxidant activity of essential oil from Carum carvi L. (car...
Essential oils have significant antioxidant activity, being used frequently as preservatives in the food and cosmetic industries. Aim: To assess the in vitro antioxidant activity of essential oil from Carum carvi L. (caraway) cultivated in northeastern Romania. Materials and Methods: The essential oil was isolated by hydrodistillation from dried caraway fruits. The chemical composition was investigated by gas chromatography and gas chromatography–mass spectrometry analyses. Antioxidant activity was evaluated by three different in vitro antioxidant assays (DPPH∙ and ABTS•+ scavenging and reducing power assays). Butylhydroxyanisole was used as reference standard. Results and Discussion: Carvone was the major compound of essential oil of caraway fruits (48.53%), followed by limonene (44.42%). Evaluation of the antioxidant activity (DPPH∙and ABTS•+ scavenging activity and reducing power) revealed significant effects, with IC50 values of 46.51 ± 1.61 µg/mL, 5.34 ± 0.07 µg/mL and 7.64 ± 0.22 µg/mL, respectively, as compared to those of the reference standard, butylhydroxyanisole (6.09 ± 0.27 µg/mL, 1.49 ± 0.00 µg/mL and 3.39 ± 0.07 µg/mL, respectively). Conclusions: Essential oil of Carum carvi cultivated in northeastern Romania belongs to carvone chemotype. Due to its high antioxidant activity it might be a potential alternative to conventional preservatives in the food, cosmetic and pharmaceutical industries.
Assessment of In Vitro Antioxidant activity of Some New Ferulic Acid Derivatives.
Stan CD, Drăgan M, Iacob AT … +1 more , Profire L
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30152662
AIM: The in vitro antioxidant potential of new thiazolidin-4-one derivatives of ferulic acid was evaluated according to the total antioxidant activity and ferric reducing power assays. MATERIAL AND METHODS: The ferric re...
AIM: The in vitro antioxidant potential of new thiazolidin-4-one derivatives of ferulic acid was evaluated according to the total antioxidant activity and ferric reducing power assays. MATERIAL AND METHODS: The ferric reducing power assay was based on the reduction of ferricyanide to ferrocyanide, which form in the presence of ferric chloride a Perl Prussian blue color complex. The total antioxidant activity assay was assessed using phosphomolybdenum method. The results were expressed as effective concentration (EC50) values and ascorbic acid was used as positive control. All determinations were performed in triplicate. RESULTS: It was found that the activity of the tested compounds is influenced by the substituents on phenyl ring of the thiazolidine-4-one moiety. The most active compound was 1i, which contains 2,3-diOH as substituent on phenyl ring. CONCLUSIONS: A total of 10 new thiazolidin-4-one derivatives of ferulic acid were investigated for their in vitro antioxidant activity. The most active compound 1i (R=2,3-diOH) proved to be about 4 times more active than ferulic acid and comparable to ascorbic acid in both antioxidant assays.
Fast RP-HPLC Method for the Determination of Bisoprolol.
Panainte AD, Vieriu M, Ţântaru G … +2 more , Apostu M, Bibire N
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30152661
AIM: To develop and validate a fast, robust, isocratic reversed-phase high performance liquid chromatographic method for the determination of bisoprolol in bulk and pharmaceutical formulations. MATERIAL AND METHOD: Optim...
AIM: To develop and validate a fast, robust, isocratic reversed-phase high performance liquid chromatographic method for the determination of bisoprolol in bulk and pharmaceutical formulations. MATERIAL AND METHOD: Optimum separation of bisoprolol was achieved using as stationary phase a Zorbax SB-C18 column (100×3 mm; 5µm). The mobile phase was a mixture of phosphate buffer (pH = 3.5) and acetonitrile (70:30) with a flow rate of 1mL/min. The UV detection was performed at 225nm. The temperature of the column and autosampler was 25°C. The specificity was assessed by using metoprolol as internal standard. The method was validated in accordance with the current ICH guidelines in terms of linearity, limit of detection, limit of quantification, precision, accuracy, recovery and system suitability. RESULTS: The retention time for bisoprolol was 1.158 minute. The calibration graph was linear in the concentration range 5-90 µg/mL. The LOD and LOQ of bisoprolol were 1.63 μg/mL and 4.94 μg/mL, respectively. The intra and interday precision of measurements were lower than the accepted criteria (RSD ≤ 2%). The recovery values of HPLC determination of bisoprolol from tablets proved that none of the excipients influenced the results of the analysis. CONCLUSIONS: The assay it was found to be accurate, reproducible, sensitive and less time consuming. The proposed method can be successfully applied to quality control studies of pharmaceutical products.
In Vitro Dissolution Studies of Amiodarone Hydrochloride From Hydroxy-Propyl-β-Cyclodextrin/Amiodarone Inclusion Complex Formulated Into Modified-Release Tablets.
Creţeanu A, Ochiuz L, Vieriu M … +2 more , Panainte AD, Ţântaru G
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30152660
AIM: Drug release from modified-release matrix tablets made of Kollidon® SR and Chitosan is dependent on its degree of solubility in the dissolution medium as well as on the matrix forming polymer. By complexing hydrochl...
AIM: Drug release from modified-release matrix tablets made of Kollidon® SR and Chitosan is dependent on its degree of solubility in the dissolution medium as well as on the matrix forming polymer. By complexing hydrochloride amiodarone with hydroxypropyl-β-cyclodextrin, an inclusion complex was obtained, which showed an increase in solubility by more than 200%. The complex was used to obtain modified-release matrix tablets based on Kollidon® SR and Chitosan. MATERIALS AND METHODS: Matrix tablets were obtained through direct compression method of non-complexed amiodarone and inclusion complex, and they were marked F1 and F10, respectively. The two formulations were studied comparatively in terms of release kinetics of the active substance through in vitro drug release tests. Those tests were conducted using a paddle apparatus II for 12 hours and two gastrointestinal simulation liquids with different pH values relevant for oral administration - 2 hours at pH 1.2 and 10 hours at pH 6.8. The release of hydrochloride amiodarone was quantified using a validated HPLC method. Two factors were calculated to assess the release profile of amiodarone: the similarity factor f1 and difference factor f2. RESULTS: The increase in Kollidon® SR concentration resulted in a slower release of amiodarone at both pH values. The use of Chitosan resulted in a decrease of AMD release only at pH 6.8. CONCLUSIONS: The similarities between the two release profiles of AMD were confirmed by the values of the similarity factor (f1 = 43.697) and difference factor f2 (f2 = 68.263).
Esthetic Rehabilitation Through CAD/CAM Technology - Case Report.
Diaconu-Popa D, Tatarciuc M, Viţalariu A
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30148337
With the progress of dental materials and techniques, CAD/CAM system currently allows the manufacture of high precision prosthetic restorations. Zirconia is an ideal base for porcelain because the bonding process between...
With the progress of dental materials and techniques, CAD/CAM system currently allows the manufacture of high precision prosthetic restorations. Zirconia is an ideal base for porcelain because the bonding process between the zirconia and the porcelain is stronger than it is with porcelain and metal. This means that the porcelain is less likely to fracture away from a zirconia base. Zirconia can also be colored to match teeth and it is translucent, mimicking the natural look of teeth far better than any crown with a metal base could. The aim of this article is to describe a case of oral rehabilitation, involving CAD/ CAM technology for full dental crowns, using zirconia as framework.
Correlation Among Chronological Age, Dental Age and Cervical Vertebrae Maturity in Romanian Subjects.
Panainte I, Pop SI, Mártha K
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30148335
AIM: The purpose of this study was to assess the correlation among the chronological age, the dental age and the skeletal maturity in adolescents and young adults. MATERIALS AND METHODS: The material consisted of panoram...
AIM: The purpose of this study was to assess the correlation among the chronological age, the dental age and the skeletal maturity in adolescents and young adults. MATERIALS AND METHODS: The material consisted of panoramic and lateral cephalometric radiographs of 221 subjects, 146 girls (mean age 13.79 ±2.90) and 75 boys (mean age 13.46 ±2.82), inhabitants of Mures County (Central Romania). The chronological age was defined as the time from birth to the day the radiographs were taken. The dental age was evaluated according to Demirjian’s method for third molars mineralization stage. Skeletal maturity was evaluated on cephalometric radiographs using the cervical vertebrae maturation (CVM) method. Descriptive statistical and linear regression analysis was performed and a coefficient of correlation was calculated. RESULTS: The mean values obtained for cervical stages for boys and girls were significant (p=0.0171). The third molar mineralization seems to be highly correlated with the gender’s chronological age for the whole group and for both genders as well (p<0.0001). The medium age of the cervical maturation showed to be younger in girls than in boys in CS1, CS3, CS5 and CS6 stages. In CS4 stages female subjects are in advance with almost 12 months, these subjects start (CS1) and end (CS6) the cervical maturation at a younger age. CONCLUSIONS: The results indicate that significant correlation exist between the chronological age and the dental age when crown development ends and between the chronological age and CVM (CS1 and CS6 stages for girls and CS2 and CS5 stages for boys).
Evaluation of the Influence of Local Administration of Vitamin D on the Rate of Orthodontic Tooth Movement.
Iosub Ciur MD, Zetu IN, Haba D … +3 more , Viennot S, Bourgeois D, Andrian S
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30148332
Accelerated orthodontic tooth movement is currently the subject of numerous scientific studies that aimed to improve the duration of orthodontic treatment. Several approaches had been performed in order to reduce the per...
Accelerated orthodontic tooth movement is currently the subject of numerous scientific studies that aimed to improve the duration of orthodontic treatment. Several approaches had been performed in order to reduce the period in which a patient is subjected to orthodontic treatment. This are biological, surgical and physical approaches. Aim: This study has two purposes: first to assess the influence of local administration of vitamin D3 on orthodontic tooth movement and second to evaluate if there is any secondary effect of locally administration of vitamin D3 on dental roots. Material and methods: Every dental arch has been divided in two: one control quadrant and one experimental quadrant. The control canine received only conventional orthodontic treatment in comparison with the experimental canine who benefited from the association between orthodontic therapy and intraligamentary administration of vitamin D3. Results: 6 dental arches were studied. The average rate of tooth movement was greater in experimental canines compared to control canines. We recorded an average of 70 % more tooth movement for the experimental teeth compared to control ones. The differences between the two quadrants (control and experimental) are statistically significant. Conclusions: Locally administration of vitamin D3 seemed to increase the rate of orthodontic tooth movement. No root resorption was found three months after the first administration of vitamin D3 evaluated on cone-beam CT exam (cone-beam computed tomography).
Surveillance Seasonal Program. Antibiotic Resistance of Pathogenic Agents Isolated From Children With Acute Gastroenteritis, in a Region of North-East Romania.
Mihai M, Manole A, Dascălu CG … +4 more , Moraru D, Duca E, Manole M, Boldureanu D
Rev Med Chir Soc Med Nat Iasi · 2016 · PMID 30148322
The acute gastroenteritis is a population health problem, frequently met everywhere in the world. In Romania, for certain etiologies the reporting is compulsory. Also, these infections are reported in the TESSy system, t...
The acute gastroenteritis is a population health problem, frequently met everywhere in the world. In Romania, for certain etiologies the reporting is compulsory. Also, these infections are reported in the TESSy system, too (The European Surveillance System). In this context, antibiotics therapy and antibiotics resistance have a particular importance. The study aim was to assess the prevalence of bacterial pathogens involved in the etiology of acute gastroenteritis (AGE) on the Iaşi County, Romania and the surrounding areas and the determination of the profile of resistance to the antibiotics for the identified agents. Material and methods: 72 strains of isolated and identified bacterial agents involved in the acute gastroenteritis (AGE) in the case of children (0-14 years), with the exception of the Campylobacter spp., in the municipality of Iasi and its surrounding areas were studied in 2012, during the surveillance period of AGE (May to October). Results: The most frequent has been the Salmonella spp. (63.9%) from which the S. enterica Thyphimurium in 21 cases (29.2%) and S. enteritidis in 7 cases (9.7%), followed by E. coli (20.8%) from which E. coli O:127 in 3 cases (4.2%), Shigella sonnei S (13.9%) and Yersinia enterocolitica (1.4%). In the case of the children from the group of 0-1 year, the Salmonella enterica Thyphimurium has been the pathogenic agent most frequently encountered (6 cases – 29.2%), followed by Salmonella Colindale, S. enteritidis, Shigella sonnei S, E. coli O:127 registered with a frequency of 5.6%. The antibiotic resistance rates are high in the case of ampicillin (43.1%), tetracycline (31.9%), amoxicillin – clavulanic acid (26.4%), trimethoprim/ sulfametoxazole (22.2%), sulfonamides (11.1%). Conclusions: The antibiotic resistance rates are high in the case of ampicillin, tetracycline, amoxicillin – clavulanic acid, trimethoprim/ sulfametoxazole, sulfonamides.
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