Ultrasound Quarterly[JOURNAL]
Sun
200 papers
Core Needle Biopsy of the Abdominal Fat Pad for Diagnosis of Amyloidosis.
Carney BW, Navarro SM, LaRoy J … +2 more , Darrow MA, Fananapazir G
Ultrasound Q · 2026 Mar · PMID 41609562 · Publisher ↗
Amyloidosis is a rare systemic disorder that is underdiagnosed and whose incidence is increasing as the population ages. The reference standard for diagnosis is endomyocardial biopsy, though its utility as a screening to...
Amyloidosis is a rare systemic disorder that is underdiagnosed and whose incidence is increasing as the population ages. The reference standard for diagnosis is endomyocardial biopsy, though its utility as a screening tool is limited. Fine needle aspiration (FNA) and surgical excisional biopsy (SEB) of the abdominal fat pad have emerged as alternatives to endomyocardial biopsy as screening tools for amyloidosis. Given concerns about the variable sensitivity of FNA and the more invasive nature of SEB, our referring providers asked our group to perform core needle biopsies (CNB) of the abdominal fat pad. While limited prior work has reviewed the performance of fat pad CNB, the technical details of this procedure have not been described in the literature. With this technical note, we hope to encourage more radiologists to offer ultrasound-guided CNB of the abdominal fat pad as an additional procedure in the toolkit of interventional radiologists.
Role of Point-of-Care Ultrasound in the Early Diagnosis of Necrotizing Soft Tissue Infections: A Case Series.
Fernández González-Cuevas J, Herrero Alonso S
Ultrasound Q · 2026 Mar · PMID 41609526 · Publisher ↗
Necrotizing soft tissue infections (NSTIs), particularly necrotizing fasciitis (NF), are life-threatening conditions with high mortality, where early diagnosis is essential to improve outcomes. However, the clinical pres...
Necrotizing soft tissue infections (NSTIs), particularly necrotizing fasciitis (NF), are life-threatening conditions with high mortality, where early diagnosis is essential to improve outcomes. However, the clinical presentation often mimics less severe infections, contributing to diagnostic delays. This case series explores the utility of point-of-care ultrasound (POCUS) in the early recognition of NF through the presentation of 3 adult patients evaluated in the Emergency Department of a tertiary care center. All patients underwent bedside ultrasound at the time of admission, with findings corroborated by computed tomography (CT) imaging and surgical exploration. Key sonographic features included subcutaneous gas, fascial thickening, and fluid tracking along fascial planes-hallmarks suggestive of NSTI. These findings were consistent with CT scans and intraoperative assessments. Two patients underwent early surgical debridement with favorable clinical outcomes, while one was managed with palliative care due to poor baseline status. This series highlights the value of POCUS as an immediate, noninvasive, and valuable diagnostic tool that complements clinical and laboratory evaluation, facilitates prompt surgical intervention, and may contribute to improved survival in patients with NSTI.
Unilateral Versus Bilateral Carotid Doppler Measurements in Septic Shock.
Şenay H
Ultrasound Q · 2026 Mar · PMID 41609524 · Publisher ↗
Abstract loading — click title to view on PubMed.
Ultrasound-Supplemented Scoring Method for Evaluating the Activity of Idiopathic Retroperitoneal Fibrosis.
Ren L, Tian X, Song Q … +1 more , He Z
Ultrasound Q · 2026 Mar · PMID 41609521 · Publisher ↗
To investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) in idiopathic retroperitoneal fibrosis (IRPF) activity and establish an optimal ultrasound-supplemented scoring method to evaluate the activity o...
To investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) in idiopathic retroperitoneal fibrosis (IRPF) activity and establish an optimal ultrasound-supplemented scoring method to evaluate the activity of IRPF. The retrospective study included 139 CEUS examinations of 59 IRPF patients treated in our hospital from January 2017 to January 2025. They were divided into the IRPF active group (66 examinations) and the inactive group (73 examinations). The parameters between the 2 groups were compared by univariate analysis. Spearman rank correlation was used to analyze the association between the parameters and IRPF activity. Significant parameters were scored according to the correlation coefficients (rs). The receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficiency of the scoring method. Univariate analysis showed that the incidence of back pain, ESR, CRP, lesion thickness, and CEUS grade was higher in the active group than in the inactive group (P<0.01). The CEUS grade and thickness had the strongest association with IRPF activity [rs=0.710 (95% CI: 0.616-0.784) and 0.703 (95% CI: 0.608-0.778), respectively]. The total score of the active group was significantly higher than that of the inactive group (P<0.001). The ROC curve showed that the optimal cutoff value was 3 scores. The sensitivity, specificity, positive, and negative predictive values were 84.85%, 83.56%, 82.35%, and 85.92%, respectively. The area under the ROC curve was 0.935 (95% CI: 0.880-0.970). In conclusion, CEUS was an excellent noninvasive diagnostic tool for assessing the activity of IRPF.
Relationship Between Grayscale Ultrasound and Attenuation Imaging in the Evaluation of Hepatic Steatosis.
Kaadi L, Khanfour M, Choullamy T … +3 more , Bizdikian AJ, Hachem T, Hachem K
Ultrasound Q · 2026 Mar · PMID 41609514 · Publisher ↗
Non-alcoholic fatty liver disease is emerging as a global health concern. Screening is the only way to alleviate its burden. Grayscale evaluation is the most commonly used non-invasive method for this purpose, but it lac...
Non-alcoholic fatty liver disease is emerging as a global health concern. Screening is the only way to alleviate its burden. Grayscale evaluation is the most commonly used non-invasive method for this purpose, but it lacks precision and reproducibility. In contrast, attenuation imaging is an innovative technique that has not yet been extensively studied. The aim of our study is to determine the correlation between hepatic steatosis grading obtained through attenuation measurement and grayscale ultrasound assessment performed by both a physician and a resident. In addition, we aim to evaluate the reproducibility of results obtained using both methods. A prospective study was conducted on 112 patients who underwent 2 double-blinded ultrasound examinations executed by an experienced radiologist with 30 years of expertise and a fifth-year resident from October to December 2023. Consequently, for each patient, a grayscale assessment of liver fat and attenuation coefficient measurement was done by the 2 readers, and graded accordingly. For attenuation coefficient, 5 measurements were taken with respect to the quality criteria set by the vendor. No significant difference was shown in the grading of liver fat using subjective method and attenuation imaging, obtained by the physician and the resident. Our results showed good reproducibility for grading fat liver using grayscale (Cohen Kappa=0.682) and attenuation imaging (Cohen Kappa=0.729) and excellent agreement for attenuation coefficient (ICC=0.956, 2k model). Attenuation imaging is an objective ultrasound application, with better inter-observer evaluation compared with grayscale evaluation, which remains a subjective method.
Bedside US and Contrasted Enhanced US Findings in Symptomatic Neonatal Stroke: A Case Series Study Correlated With MRI.
Liu L, Zheng Q, Lin Z … +5 more , Zhou J, Xie F, Liu T, Lin Y, Zhou L
Ultrasound Q · 2025 Dec · PMID 41494107 · Publisher ↗
The purpose of this study was to evaluate bedside cranial ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) for demonstrating changes in neonatal arterial ischemic stroke (NAIS). Fifteen newborns with symptomatic...
The purpose of this study was to evaluate bedside cranial ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) for demonstrating changes in neonatal arterial ischemic stroke (NAIS). Fifteen newborns with symptomatic NAIS underwent a cranial ultrasound examination and subsequently confirmed by magnetic resonance imaging (MRI), were enrolled. Color Doppler Flow Imaging (CDFI) and Pulsed-Wave Doppler (PW) were performed to acquire data from 6 coronal, 5 sagittal, and 3 cerebellar planes through the anterior or mastoid fontanelle. For CEUS, a 2-minute wash-in cine clip and static images were captured. CUS showed all lesions in the blood-supplying region of the middle cerebral artery (MCA), with 10(66.7%) located on the left hemisphere, and on the right. CEUS was performed on 3 neonates to evaluate microvascular perfusion. Two cases showed a large area of non-enhancement on the lesion side, while the third case showed significantly higher enhancement on the lesion side. MRI confirmed all lesions in the MCA blood-supplying region, with 10 on the left hemisphere and 5 on the right. Magnetic resonance angiography (MRA) identified abnormalities in the trunk or branches of the MCA in 8 neonates. Our preliminary results suggest that CUS can evaluate NAIS in conjunction with MRI and CEUS metrics may have potential for clinical quantification, warranting future validation studies.
Sonographic Features of Acute Sigmoid Diverticulitis Detected During Pelvic Pain Evaluation.
Tavana A, Caserta MP
Ultrasound Q · 2025 Dec · PMID 41490441 · Publisher ↗
Acute diverticulitis, which arises from inflammation of a colonic diverticulum, is a prevalent cause of acute abdominal pain and hospitalization in developed countries. Although most cases respond to conservative treatme...
Acute diverticulitis, which arises from inflammation of a colonic diverticulum, is a prevalent cause of acute abdominal pain and hospitalization in developed countries. Although most cases respond to conservative treatment, serious complications such as perforation and formation of large abscesses and fistulas can arise, which would require urgent intervention. In the United States, computed tomography (CT) is the diagnostic standard, offering sensitivity and specificity >95%, but ultrasound has also proven effective in identifying uncomplicated cases of diverticulitis.
Cost-Effectiveness of Thyroid Nodule Risk Stratification Guidelines.
Vankka N, Bao B, Webb A … +2 more , Seidler M, Fung C
Ultrasound Q · 2025 Dec · PMID 41490439 · Publisher ↗
The goal of this study is to evaluate the cost savings of consistently adhering to the 2017 American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) and the 2015 American Thyroid Associatio...
The goal of this study is to evaluate the cost savings of consistently adhering to the 2017 American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) and the 2015 American Thyroid Association (ATA) criteria for the evaluation of thyroid nodules. In this retrospective study, 2 radiologists independently reviewed ultrasound (US) features of 291 cytology-proven thyroid nodules and scored them based on the ACR TI-RADS and ATA guidelines. The expected costs of strict adherence to recommendations based on the 2 risk stratification guidelines were calculated and compared with the actual cost to the health care system. Strict adherence to risk stratification guidelines can save the regional health care system up to $88,000 annually based on the 291 thyroid nodules examined. With retrospective application of ACR TI-RADS criteria, 51 nodules were recommended for follow-up US and 147 for fine-needle aspiration biopsy. With ATA criteria, 9 nodules were recommended for follow-up US, and 261 for fine-needle aspirations. Although fewer nodules were recommended for biopsy with TI-RADS criteria, the majority met criteria for follow-up US. Between the two guidelines, the ACR-TI-RADS offered slightly greater savings of ∼$3000 annually compared with ATA. Strict adherence to ACR TI-RADS and ATA guidelines can lead to substantial cost savings for the health care system by eliminating unnecessary thyroid biopsies. ACR TI-RADS is more cost-effective compared with ATA.
A Comparative Study of Pleomorphic Adenoma and Warthin Tumor Using Ultrasonography and Clinical Features.
Liu W, Zhang F, Pang K … +3 more , Bao Y, Zhang L, Wei X
Ultrasound Q · 2025 Dec · PMID 40986797 · Publisher ↗
Pleomorphic adenomas and Warthin tumors are the most common benign tumors affecting the parotid glands. This pilot study aims to improve the accuracy of ultrasound diagnosis of pleomorphic adenoma and Warthin tumor in th...
Pleomorphic adenomas and Warthin tumors are the most common benign tumors affecting the parotid glands. This pilot study aims to improve the accuracy of ultrasound diagnosis of pleomorphic adenoma and Warthin tumor in the parotid gland. From December 2015 to December 2022, patients who had complete clinical data, preoperative ultrasonography, and postoperative pathologic confirmation of pleomorphic adenoma or Warthin tumor and underwent surgery at our hospital were retrospectively analyzed. There were statistically significant differences between pleomorphic adenoma and Warthin tumor in terms of age, gender, smoking history, number of lesions, lymph node-like morphology, internal echo homogeneity, echogenicity, and blood flow pattern in nodules (P <0.05). Univariate analysis identified variables with statistical significance (P < 0.05), which were further included as independent variables in a multivariate logistic regression model, and the results showed that the model was statistically significant (model χ2=2.843, P＜0.05, R2=0.089). In addition, a receiver operating characteristic curve was generated, incorporating the 3 independent variables of age, nodule length to thickness ratio, and echo homogeneity, revealing an area under the curve of 0.976±0.010, P < 0.001, with a 95% CI of 0.934 to 0.995. Our present study identified age, nodule length-to-thickness ratio, and echo homogeneity as significant indicators in differentiating these tumors. Moreover, these 3 variables have significance in predicting these tumors.
Microwave Ablation of Benign Thyroid Nodules: The Importance of Modified Hydrodissection.
Demirsah AC, Kucukay F
Ultrasound Q · 2025 Dec · PMID 40986796 · Publisher ↗
To evaluate the safety and efficacy of microwave ablation (MWA) in treating benign thyroid nodules and any advantage of modified hydrodissection (MHD) techniques while performing these procedures. This retrospective stud...
To evaluate the safety and efficacy of microwave ablation (MWA) in treating benign thyroid nodules and any advantage of modified hydrodissection (MHD) techniques while performing these procedures. This retrospective study included 76 consecutive patients treated for benign thyroid nodules using MWA. Patients were divided into 2 groups. Group 1 included patients treated before November 2019 using the hydrodissection technique (n = 38), and group 2 included patients treated using the MHD technique after November 2019 (n = 38). Hydrodissection-MHD was performed using 5% dextrose. A portable MWA device with a 2450 MHz frequency was used as the generator. MWA antennas with internal water-cooled units and temperature monitoring features with a 16G diameter, 100 cm body length, and 3 mm tip length were used for MWA procedures. Color Doppler ultrasound examinations, thyroid function tests, volume reduction ratios, Visual Analog Scales, and Cosmetic Scores were performed on the patients in the first, third, sixth, and every sixth months after ablation procedures. Complications and procedure times were also recorded. No significant differences in volume reduction ratios, Visual Analog Scale, or Cosmetic Score were observed between the groups at 3, 6, and 12 months. Lower complication rates ( 26.31% vs 7.89%, P = 0.03) and procedure times (10.30 vs 7.30 min; P = 0.04) were observed with the MHD technique. There were no residual or recurrent nodules or thyroid hormone deficiencies during the follow-up. MWA of benign thyroid nodules is safe and effective. Using the MHD technique lowers complication rates and procedure time.
Ultrasound Findings in Endosalpingiosis: A Closer Look at an Overlooked Condition.
Barbee V, Caserta MP, Patel N
Ultrasound Q · 2025 Dec · PMID 40986794 · Publisher ↗
Endosalpingiosis is a rare, benign condition characterized by ectopic cystic glands lined with ciliated cuboidal epithelium, histologically resembling the fallopian tube. Its etiology remains uncertain but is hypothesize...
Endosalpingiosis is a rare, benign condition characterized by ectopic cystic glands lined with ciliated cuboidal epithelium, histologically resembling the fallopian tube. Its etiology remains uncertain but is hypothesized to result from either ectopic implantation of fallopian tube tissue or metaplastic transformation of multipotential peritoneal cells. While frequently misdiagnosed as endometriosis, endosalpingiosis coexists with endometriosis in ~35% to 40% of cases. The condition can affect both women of reproductive age and postmenopausal individuals, with a median age of diagnosis between 50 and 52 years. While often asymptomatic, patients may present with infertility, pelvic pain (including dysmenorrhea and dyspareunia), pelvic masses, or urinary symptoms such as hematuria or dysuria when lesions involve the urinary bladder. Lesions primarily localize to the peritoneal surfaces of the uterus, fallopian tubes, ovaries, and cul-de-sac but can rarely extend to the bladder, ureters, bowel serosa, omentum, lymph nodes, appendix, cervix, and even the skin. Endosalpingiosis is considered part of the spectrum of peritoneal serous lesions and may be associated with or progress to borderline or low-grade ovarian serous neoplasms. Sonographic evaluation typically reveals multiple small, anechoic, and avascular cystic structures forming a "bunch-of-grapes" pattern along pelvic and peritoneal surfaces.
Idiopathic Scrotal Calcinosis: Sonographic Hallmarks.
Zaazoue KA, Caserta MP
Ultrasound Q · 2025 Dec · PMID 40910926 · Publisher ↗
Idiopathic scrotal calcinosis (ISC) is a rare, benign dermatological condition consisting of deposits of calcium within the scrotal skin. On examination, ISC is characterized by painless, firm nodules and papules localiz...
Idiopathic scrotal calcinosis (ISC) is a rare, benign dermatological condition consisting of deposits of calcium within the scrotal skin. On examination, ISC is characterized by painless, firm nodules and papules localized to the scrotal skin. Typically presenting in adolescence or early adulthood, ISC is more prevalent in males aged 20 to 40, though cases have been reported across all age groups. The lesions initially match the skin tone but may become yellowish and lobulated, sometimes discharging a chalky white substance. Despite its unclear etiology, ISC is hypothesized to arise either idiopathically or through calcification of preexisting dermal structures. More recently, some researchers have suggested that degeneration of the dartos muscle may play a role in the pathogenesis of ISC, like the process of calcification in uterine fibroids. Imaging, particularly ultrasound, plays a pivotal role in diagnosis by identifying hyperechoic, avascular nodules within the scrotal dermis. These can be further characterized by computed tomography and magnetic resonance imaging, however, not usually required. Histopathologic examination remains the gold standard for definitive diagnosis postexcision. Surgical removal is the only effective treatment and is usually performed for cosmetic purposes. Awareness of ISC's imaging features is essential for accurate diagnosis and management.
Evaluating the Role of Critical Care Ultrasonography in Predicting Volume Responsiveness Among Septic Shock Patients Undergoing Fluid Resuscitation: A Clinical Study.
Cui J, Huang L, Shang X … +1 more , Liu M
Ultrasound Q · 2025 Sep · PMID 40690208 · Publisher ↗
This study aimed to evaluate the predictive efficacy of critical care ultrasonography for volume responsiveness in septic shock patients undergoing fluid resuscitation. Ninety septic shock patients admitted between Janua...
This study aimed to evaluate the predictive efficacy of critical care ultrasonography for volume responsiveness in septic shock patients undergoing fluid resuscitation. Ninety septic shock patients admitted between January 2021 and December 2023 were divided into responsive and nonresponsive groups based on fluid responsiveness. Ultrasonic indices, including velocity time integration (ΔVTI), corrected flow time (ΔFTc), peak velocity of the carotid artery (ΔVpeakCA), and Respiratory Variation Index (RVI), as well as oxygen metabolism parameters, were measured before and after the fluid resuscitation trial. The correlation between ultrasonic indices and stroke volume variation (SVV) was assessed, and the predictive efficacy of these indices was analyzed using receiver operating characteristic curves. Results showed that ΔVTI, ΔFTc, ΔVpeakCA, RVI, and SVV were significantly lower in the nonresponsive group compared with the responsive group (P < 0.05). Pearson correlation analysis indicated a strong positive correlation between ΔVTI, ΔFTc, ΔVpeakCA, RVI, and SVV (r = 0.737, 0.741, 0.743, 0.739). Receiver operating characteristic analysis revealed that the areas under the curve for ΔVTI, ΔFTc, ΔVpeakCA, RVI and the combined indices were 0.944, 0.867, 0.874, and 0.935, respectively. Postresuscitation, the responsive group demonstrated significantly higher central venous oxygen saturation levelselevated partial pressure of oxygen and markedly reduced lactate levels compared with the nonresponsive group. These findings suggest that ΔVTI, ΔFTc, ΔVpeakCA, and RVI are effective for assessing volume responsiveness in mechanically ventilated septic shock patients, with the responsive group showing improved resuscitation outcomes.
Gray-Scale Ultrasonography of Lung and Sonoelastography of the Diaphragm in Interstitial Lung Disease With HRCT Association.
Jain P, Dash S, Chandak S … +4 more , Panda S, Malhotra A, Nirala P, Afifa U
Ultrasound Q · 2025 Sep · PMID 40669041 · Publisher ↗
Interstitial lung disease (ILD) is a heterogeneous group of disorders characterized by diffuse inflammation of the pulmonary parenchyma and alveoli, along with interstitial fibrosis. High-resolution computed tomography (...
Interstitial lung disease (ILD) is a heterogeneous group of disorders characterized by diffuse inflammation of the pulmonary parenchyma and alveoli, along with interstitial fibrosis. High-resolution computed tomography (HRCT) of the thorax remains the mainstay for diagnosis. Adjunct tools for diagnosis and follow-up imaging include gray-scale lung ultrasonography (LUS) and sonoelastography of the diaphragm, or diaphragm elastography (DE); however, limited research has been conducted on LUS and DE in patients with ILD. We conducted a cross-sectional observational study using LUS and DE in 56 patients diagnosed with ILD on HRCT. We found a strong correlation (P<0.05) between ground-glass opacities (GGOs) and reticulations on HRCT with the B-line score on LUS, indicating its reliability in assessing early and diffuse interstitial changes. In contrast, the presence of honeycombing on CT showed better correlation (correlation coefficient r 0.49) with stiffer diaphragms as compared with GGO (correlation coefficient r 0.14), suggesting its potential role in evaluating advanced fibrotic changes. Hence, we concluded that combining LUS and DE may enhance diagnostic and staging accuracy for ILD, eliminating patient exposure to ionizing radiation.
A Feasible Simplified Pulmonary Ultrasound Scoring System for Evaluating Interstitial Lung Disease.
Liu Q, Sun L, Li F … +7 more , Yang L, Cao W, He L, Zhang H, Zhu Y, Liu Y, Shen E
Ultrasound Q · 2025 Jun · PMID 40388428 · Publisher ↗
Transthoracic lung ultrasound is becoming increasingly important in the diagnosis and treatment of interstitial lung disease. However, no standard examination has been developed for pulmonary ultrasound scanning. The pur...
Transthoracic lung ultrasound is becoming increasingly important in the diagnosis and treatment of interstitial lung disease. However, no standard examination has been developed for pulmonary ultrasound scanning. The purpose of this study was to evaluate the clinical value of simplified transthoracic pulmonary ultrasound scoring through 6 intercostal spaces for the assessment of interstitial lung disease severity. Two hundred nineteen patients who underwent pulmonary ultrasound at our institution were included. Patients were divided into a non-interstitial lung disease group (57 participants) and an interstitial lung disease group (162 participants). The 6-intercostal space method was used for pulmonary ultrasound examination and scoring. The Warrick score of high-resolution computed tomography and lung function indicators were used as the gold standards to evaluate the consistency of the 3 methods in grading interstitial lung disease severity. When lung function indicators were used as the gold standard, a strong consistency was observed between the 6-rib interstitial lung ultrasound scores and the lung function indicators (κ value = 0.841, 95% CI = 0.740-0.941); a strong consistency was also observed between the high-resolution computed tomography scores and the lung function indicators (κ value = 0.664, 95% CI = 0.525-0.803). When the high-resolution computed tomography score was used as the gold standard, a strong consistency was observed between the 6-rib interstitial lung ultrasound score and the high-resolution computed tomography score (κ value of 0.718 (95% CI = 0.618-0.818). A simplified 6-intercostal space pulmonary ultrasound score can be used to evaluate interstitial lung disease severity and better facilitate clinical treatment.
Quantification of Initial Symptom Relief Following Ultrasound-Guided Radiofrequency Ablation of Benign Thyroid Nodules.
Atwell TD, Schmitz JJ, Ryder M … +5 more , Roll RJ, Castro MR, Kurup AN, Kassmeyer BA, Stan MN
Ultrasound Q · 2025 Jun · PMID 40369808 · Publisher ↗
The use of radiofrequency ablation (RFA) of benign, symptomatic thyroid nodules is growing in clinical practice. Objective outcomes of symptom relief are needed to support the use of this treatment. Thus, a previously es...
The use of radiofrequency ablation (RFA) of benign, symptomatic thyroid nodules is growing in clinical practice. Objective outcomes of symptom relief are needed to support the use of this treatment. Thus, a previously established thyroid nodule symptom scoring system was prospectively administered to patients prior to RFA of symptomatic thyroid nodules and then at 1, 3, 6, and 12 months following ablation.A total of 38 patients of mean age 57 years were treated with RFA between August 2022 and January 2024 and completed at least 1 follow-up survey. Five of these patients underwent simultaneous ablation of 2 thyroid nodules; the remainder had a single nodule treated. Mean modified symptom score prior to RFA was 3.5 (SD 1.6) with higher scores correlating with increasing baseline nodule volume (R = 0.46, P = 0.0038). Patient symptom scores decreased at the first 1-month survey (mean 1.2; SD 1.3) and 3-month survey (mean 0.9; SD 1.3) with durable response in those patients with more extended follow-up. In those patients with imaging follow-up, decreasing nodule size was shown to correlate with decreasing symptoms.The early results of this study show that RFA of benign, symptomatic thyroid nodules results in quantifiable symptom relief within 3 months of treatment. Such objective measures of symptom relief may be used to measure long-term durability of treatment.
Second-Look Ultrasound: When Things Are Not Always as They Seem.
Úbeda B, Mensión E, Ganau S … +6 more , Sitges C, Macedo M, Gasior DM, Cebrecos I, Sanfeliu E, Bargalló X
Ultrasound Q · 2025 Jun · PMID 40367329 · Publisher ↗
The purpose of this study was to compare size, morphologic features, and degree of suspicion between findings at second-look ultrasound (SL-US) and additional lesions with histological confirmation detected on breast mag...
The purpose of this study was to compare size, morphologic features, and degree of suspicion between findings at second-look ultrasound (SL-US) and additional lesions with histological confirmation detected on breast magnetic resonance imaging (MRI). We performed an observational retrospective study including women who underwent SL-US between January 2021 and August 2022. Size, morphology according to Breast Imaging Reporting and Data System (BI-RADS) lexicon, and BI-RADS categories were analyzed for MRI and US findings. Two hundred twenty-four consecutive patients (aged 29-88 years; mean, 59.2 years) underwent SL-US to identify 235 additional lesions detected on MRI. US identified 173 (73.6%) findings. US- guided biopsy was performed in 148 (85.5%) of the detected lesions, proving 56 (37.8%) malignant and 92 (62.2%) benign. Mean size was 15.2 mm on MRI and 9.4 mm on US. Foci and masses showed good correlation, whereas nonmass enhancements tended to appear larger on MRI, and this difference was statistically significant (P = 0.0001). Morphology showed a higher agreement in the case of foci and masses than with nonmass enhancements. BI-RADS categories agreed in 66 cases (44.6%), whereas in 61 cases (41.2%), the degree of suspicion was higher for MRI, and in only 21 cases (14.2%) were lesions more suspicious on US than on MRI. In conclusion, lesions detected at SL-US show a higher agreement in size and morphologic features for foci and masses than with nonmass enhancements and similar or lower degree of suspicion than on MRI; therefore, decision to perform a biopsy should be based primarily on MRI findings.
Enhancing the Detection of Malignancy in Thyroid Nodules by Assessing Longitudinal Diameter-to-Anteroposterior Diameter Ratio.
Ozel A, Cakmakcı E, Camurcuoglu E
Ultrasound Q · 2025 Jun · PMID 40237405 · Publisher ↗
The aim of investigate the ability of 3-dimensional diameter measurements of the nodule to predict malignant nodules. Adult patients with thyroid nodules who underwent thyroid surgery or fine-needle aspiration biopsy bet...
The aim of investigate the ability of 3-dimensional diameter measurements of the nodule to predict malignant nodules. Adult patients with thyroid nodules who underwent thyroid surgery or fine-needle aspiration biopsy between December 2017 and December 2022 were included in this retrospective study. Thyroid ultrasound images and final pathology results were collected. Nodule size was remeasured using recorded ultrasound images in 3 dimensions (longitudinal, anteroposterior, and transverse). The ratios of the longitudinal diameter to the transverse diameter (L/T), the longitudinal diameter to the anteroposterior diameter (L/AP), and the anteroposterior diameter to the transverse diameter (AP/T) were calculated. The recent American College of Radiology TI-RADS system was used for the ultrasonographic scoring of the nodules. Patients were grouped as benign or malignant based on their final pathology results. In total, 398 (70.69%) patients had benign nodules and 165 (29.31%) patients had malignant nodules. The malignant group was significantly older than the benign nodule group (P = 0.011), while sex distributions were similar (P = 0.101). Malignant nodules could be predicted with the following cutoff values: L/T ≤ 0.97 (P < 0.001), L/AP ≤1.6 (P < 0.001), and AP/T > 1.0 (P < 0.001) or >0.94 (P < 0.001). Multivariable logistic regression indicated that low (≤1.6) L/AP ratio and high scores for echogenicity, shape, margin, and echogenic foci were independently associated with malignancy. Combining the L/AP ratio with the AP/T ratio could improve the discrimination of malignant thyroid nodules from benign nodules. Incorporating the L/AP ratio into new risk classification systems warrants careful consideration.
Application of Transperineal Ultrasound in Assessing the Impact of the Degree of Uterine Prolapse on the Anterior Compartment.
Li Y, Ye C, Lin L … +5 more , Ye Q, Guo J, Chen Z, Xue E, Lin X
Ultrasound Q · 2025 Jun · PMID 40211449 · Publisher ↗
This study was performed to assess how the degree of uterine prolapse affects the anterior pelvic compartment using transperineal ultrasound. This single-center, retrospective study included 287 patients with uterine pro...
This study was performed to assess how the degree of uterine prolapse affects the anterior pelvic compartment using transperineal ultrasound. This single-center, retrospective study included 287 patients with uterine prolapse as assessed by transperineal ultrasound. The patients were categorized into mild and severe groups based on the severity of uterine prolapse. All patients underwent pelvic floor ultrasonography, during which the bladder neck descent, lowest point of the bladder, retrovesical angle, urethral tilt angle, and urethral rotation angle were observed to classify cystocele types. In the mild group, 38.2% (37/97) of patients were diagnosed with a cystourethrocele, and the incidence of urinary incontinence was 67.0% (65/97). Both of these rates were higher than the corresponding rates of 33.7% (64/190) and 53.7% (102/190) in the severe group (P < 0.01). Conversely, 55.2% (105/190) of patients in the severe group were diagnosed with an isolated cystocele. Dysuria was observed in 20.0% (38/190) of these patients, which was significantly higher than the rates of 34.0% (33/97) and 8.2% (8/97) in the mild group (P < 0.05). The degree of uterine prolapse affects the type of cystocele and lower urinary tract symptoms. More severe uterine prolapse is associated with a higher incidence of isolated cystocele and lower incidence of urinary incontinence.
Liver Fat Quantification With Ultrasound: The Influence of the Size of the Region of Interest on Attenuation Coefficient.
Choullamy T, Kaadi L, Bezdikian A … +2 more , Hachem S, Hachem K
Ultrasound Q · 2025 Jun · PMID 40173292 · Publisher ↗
Noninvasive assessment of liver fat content is crucial due to the high global prevalence of nonalcoholic fatty liver disease. Algorithms based on ultrasound (US) attenuation coefficient (AC) for estimating liver fat cont...
Noninvasive assessment of liver fat content is crucial due to the high global prevalence of nonalcoholic fatty liver disease. Algorithms based on ultrasound (US) attenuation coefficient (AC) for estimating liver fat content are commercially available, but a lack of consensus exists regarding the best estimation protocol. The aim of our study was to evaluate the influence of the size of the region of interest (ROI) on the US AC.A prospective study was conducted. An abdominal US was done for 86 outpatients. A sampling box was positioned within the liver parenchyma, approximately 2 cm beneath the liver capsule with a ROI, measuring about 2 × 4 cm and then 4 × 5 cm, precisely placed at the center of this sampling box. Five readings of the AC were captured, and the average of these measurements was employed to assess the severity of hepatic steatosisA statistically significant difference between AC with 2 different ROI sizes was shown (P < 0.001) with AC values with 2 × 4 cm ROI were higher than those obtained with 4 × 5 cm ROI (AC mean 0.668 VS 0.653). However, the agreement between AC values obtained with 2 different ROI sizes was excellent (correlation coefficient 0.941)An ROI size dependence is observed in the measurement of AC in the liver. A standardized acquisition protocol with a fixed size of the ROI needs to be developed to minimize differences in AC measurements and to assess changes in serial measurements reliably.
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