Journal Of Cosmetic Dermatology[JOURNAL]
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200 papers
Clinical Outcomes of an Innovative Poly-L-Lactic Acid (LASYNPRO) in Facial Rejuvenation: Prospective, Multicenter Spanish Study.
Urdiales-Gálvez F, Benítez PA, Díaz I
J Cosmet Dermatol · 2026 Feb · PMID 41715284 · Full text
OBJECTIVE: To evaluate the clinical efficacy, patient satisfaction, safety profile, and biological impact of Poly-L-lactic acid (PLLA LASYNPRO) over 6 months. METHODS: This prospective, multicenter study included patient...
OBJECTIVE: To evaluate the clinical efficacy, patient satisfaction, safety profile, and biological impact of Poly-L-lactic acid (PLLA LASYNPRO) over 6 months. METHODS: This prospective, multicenter study included patients treated with PLLA-LASYNPRO. The primary end-point was the proportion of participants who achieved a reduction of at least 1 point in the Wrinkle-Severity-Rating-Scale (WSRS). Secondary end-points included the proportion of participants achieving at least a 1-point reduction in the Midface-Volume-Deficit-Scale (MFVDS), the degree of patient satisfaction assessed by the Global-Aesthetic-Improvement-Scale (GAIS), treatment-related biological and structural changes, and the incidence of adverse events (AEs). RESULTS: Thirty-six female subjects were enrolled. Right-side treatment success rates increased from 44.4% at month-1 to 71.9% at month-6 (Cochran's Q, p = 0.005); left-side rates increased from 44.4% to 68.8% (p = 0.006). MFVDS-treated-side success increased significantly (44.4% to 65.6%; p = 0.004). GAIS ratings of "Much Better" or "Better" were reported by 66.7% at month 1 and remained high (65.6% at month-6). Ultrasound and elastography imaging confirmed increased tissue density, reduction of the Sub-Epidermal-Low-Echogenic-Band (SLEB), signs of neocollagenesis, and improved viscoelasticity. Serum P1CP levels rose significantly from 134.6 ± 98.9 ng/mL to a peak of 233.2 ± 163.1 ng/mL at month 2 (p < 0.001 vs. baseline), remaining elevated through month 6 (p = 0.012). AEs were limited to mild-moderate, self-resolving inflammation, erythema, edema, and injection-site discomfort; no serious AEs occurred. CONCLUSION: PLLA-LASYNPRO achieved significant, sustained improvements in facial wrinkles and volume with high patient satisfaction and biological evidence of collagen stimulation. The treatment demonstrates an excellent safety profile. Further large-scale, randomized trials are recommended to confirm long-term efficacy and define its role in aesthetic practice.
Post-Botulinum Headache in Cosmetic Practice: A Prospective Study.
Akpınar Ü, Vural O, Civas E … +1 more , Koycu A
J Cosmet Dermatol · 2026 Feb · PMID 41709680 · Full text
BACKGROUND: Botulinum toxin is widely used for aesthetic and functional indications and is generally considered safe; however, post-procedural headache remains a recognized but underexplored adverse effect, particularly...
BACKGROUND: Botulinum toxin is widely used for aesthetic and functional indications and is generally considered safe; however, post-procedural headache remains a recognized but underexplored adverse effect, particularly in cosmetic practice. OBJECTIVE: To evaluate the incidence, characteristics, and potential risk factors of headache following botulinum toxin injections administered to different anatomical regions. METHODS: This prospective observational study included 102 adult patients undergoing abobotulinumtoxinA injections to the upper facial regions, masseter muscles, and/or axillary area. Headache occurrence was assessed on day 3 by telephone, at days 10-12 during follow-up visits, and through patient-initiated contact within the first month. Demographic variables, prior botulinum toxin exposure, injection-related pain, toxin dose, and headache characteristics were recorded. RESULTS: Post-botulinum headache occurred in 13 patients (12.7%) and was generally mild-to-moderate, short-lived, and self-limited. Headache was significantly more frequent in first-time recipients compared with previously treated patients (45.5% vs. 8.8%, p = 0.005). All patients who developed headache had received injections involving the upper facial regions, whereas no headache was observed after exclusive masseter or axillary treatments. No associations were found with toxin dose, procedural pain, or systemic comorbidities. CONCLUSION: Post-botulinum headache is an infrequent, benign, and transient event, predominantly affecting first-time patients undergoing upper facial injections. These findings may aid clinicians in patient counseling and expectation management.
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Propranolol Versus Other Drugs in the Treatment of Infantile Hemangioma.
Hu J, Pan L, Kong H … +1 more , Lou J
J Cosmet Dermatol · 2026 Feb · PMID 41700540 · Full text
OBJECTIVE: This study aimed to systematically evaluate and compare the efficacy and safety of propranolol versus atenolol, corticosteroids, timolol, and other therapies in the treatment of infantile hemangioma (IH) throu...
OBJECTIVE: This study aimed to systematically evaluate and compare the efficacy and safety of propranolol versus atenolol, corticosteroids, timolol, and other therapies in the treatment of infantile hemangioma (IH) through a meta-analysis, thereby providing evidence-based guidance for clinical practice. METHODS: A comprehensive literature search was conducted across PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, and Wanfang databases from inception to December 2025. The protocol was prospectively registered with PROSPERO (CRD420261294316). Randomized controlled trials (RCTs) or clinical controlled trials (CCTs) comparing oral propranolol with other active drugs in IH patients aged ≤ 12 years were included. Primary outcomes were overall response rate (≥ 50% reduction), complete remission rate, and incidence of adverse events. Two reviewers independently performed study selection, data extraction, and quality assessment using the Cochrane RoB 2.0 tool and Newcastle-Ottawa Scale. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using R software. Heterogeneity was assessed using the I statistic. RESULTS: Eight studies involving 900 patients (propranolol: 464; control: 436) were included. Meta-analysis revealed no statistically significant difference in overall response rate between propranolol and control groups (pooled OR = 1.29, 95% CI: 0.80-2.09, p = 0.30). However, propranolol demonstrated a significantly higher complete remission rate (OR = 1.35, 95% CI: 1.01-1.82, p = 0.045). Subgroup analyses by control drug type (atenolol, corticosteroids, timolol, combination therapy) showed no significant differences in efficacy (all p > 0.05). Safety analysis indicated no significant difference in adverse event incidence between groups (OR = 0.76, 95% CI: 0.38-1.55, p = 0.45), albeit with moderate heterogeneity (I = 56%). Heterogeneity was low for efficacy outcomes (I = 0%). Funnel plot symmetry and a non-significant Egger's test suggested a low risk of publication bias. CONCLUSION: Propranolol offers a statistically significant advantage in achieving complete remission of infantile hemangioma compared to other active agents, while maintaining comparable overall response rates and a similar overall safety profile. These findings support propranolol as a first-line therapy when complete lesion resolution is the primary goal. Atenolol represents an effective alternative, particularly for patients with specific tolerability concerns, underscoring the need for individualized treatment selection.
Xanthelasma-Like Reaction Following Poly-L-Lactic Acid Intradermal Injection Managed With Fractional Non-Ablative Lasers and Stem Cell-Derived Conditioned Media: A Case Report.
Wibisono O, Fang M, Yi KH … +1 more , Junawanto I
J Cosmet Dermatol · 2026 Feb · PMID 41699701 · Full text
BACKGROUND: Xanthelasma-like periocular plaques are rare adverse reactions following injectable collagen stimulators and may be challenging to manage in cosmetically sensitive areas. AIMS: To describe a rare xanthelasma-...
BACKGROUND: Xanthelasma-like periocular plaques are rare adverse reactions following injectable collagen stimulators and may be challenging to manage in cosmetically sensitive areas. AIMS: To describe a rare xanthelasma-like reaction after polymer-based collagen stimulator (poly-L-lactic acid or poly-D,L-lactic acid) intradermal injection and its management using fractional non-ablative lasers and stem cell-derived conditioned media. PATIENTS/METHODS: A 49-year-old woman with Fitzpatrick skin type IV developed bilateral infraorbital yellowish plaques (~1 × 2 cm) approximately two weeks after a collagen stimulator injection and presented four months later with persistent lesions, after showing minimal response to a prior 577-nm yellow laser treatment performed at another clinic. Our first treatment approach consisted of a fractional 1550-nm erbium glass laser combined with intralesional 0.9% sodium chloride and a short course of oral corticosteroids. A subsequent session incorporated combined fractional 1550-nm erbium glass and 1450-nm diode lasers, followed by intradermal stem cell-derived conditioned media. RESULTS: Partial improvement was observed after the initial treatment. Further improvement was achieved following combination laser therapy with adjunctive stem cell-derived conditioned media, with marked lesion flattening and reduced erythema within two months and sustained improvement at four-month follow-up. CONCLUSIONS: This case highlights a rare xanthelasma-like reaction following polymer-based collagen stimulator injection and demonstrates that a staged, non-ablative fractional laser approach with adjunctive stem cell-derived conditioned media may be an effective and minimally invasive management option.
Integrated CO Laser Treatment and Cognitive-Behavioral Therapy for Postadolescent Acne Excoriée: Clinical Outcomes From a Case Series.
Penev J, Balabanova M, Jafferany M
J Cosmet Dermatol · 2026 Feb · PMID 41693228 · Full text
BACKGROUND: Self-inflicted skin injury is a significant yet often underrecognized contributor to acne progression, particularly in postadolescent populations. It not only perpetuates lesions but also triggers inflammator...
BACKGROUND: Self-inflicted skin injury is a significant yet often underrecognized contributor to acne progression, particularly in postadolescent populations. It not only perpetuates lesions but also triggers inflammatory cascades, including sebaceous gland epithelialization and cystic transformation. Postadolescent acne excoriée poses unique therapeutic challenges due to the interplay of dermatological and psychological factors. AIMS: To evaluate the effectiveness of a combined psychodermatological treatment-CO laser ablation and cognitive-behavioral therapy (CBT)-in managing chronic, treatment-resistant postadolescent acne excoriée. METHODS: A case series of three patients with refractory postadolescent acne excoriée was conducted. Treatment involved CO laser ablation to remove obstructed sebaceous glands, combined with CBT targeting maladaptive excoriation behaviors. RESULTS: All patients achieved rapid and sustained clinical improvement. The combined approach disrupted the pathomimetic cycle, eliminated visible obstructed sebaceous glands, and reduced compulsive skin manipulation. CONCLUSION: Integrating CO laser ablation with CBT offers a dual benefit of addressing both the physical lesions and psychological drivers of acne excoriée. Multidisciplinary collaboration is essential for effective management of complex psychocutaneous disorders.
Intralesional Interferon Alfa-2b Versus Cryotherapy for Common Warts on the Hands and Feet: A Randomized, Open-Label, Controlled Trial.
Jin Y, Shen X
J Cosmet Dermatol · 2026 Feb · PMID 41693220 · Full text
OBJECTIVE: To evaluate the clinical efficacy of interferon injection therapy for common warts on the hands and feet and to analyze its associated adverse reactions. METHODS: A total of 326 patients with common warts loca...
OBJECTIVE: To evaluate the clinical efficacy of interferon injection therapy for common warts on the hands and feet and to analyze its associated adverse reactions. METHODS: A total of 326 patients with common warts located on the hands and feet who were treated at our hospital between January 2024 and February 2025 were enrolled. Using a block randomization method, the patients were divided into a control group (n = 163, treated with cryotherapy) and an observation group (n = 163, treated with intralesional interferon alfa-2b injection). The two groups were compared in terms of clinical efficacy, number, thickness, and diameter of warts, immune function, quality of life, adverse reactions, and recurrence rates. RESULTS: After treatment, the number, thickness, and diameter of warts decreased in both groups, with significantly greater reductions in the observation group. Post-treatment levels of cluster of differentiation 3 positive (CD3), cluster of differentiation 4 positive (CD4), the CD4/CD8 ratio, interleukin-2 (IL-2), interleukin-6 (IL-6), immunoglobulin E (IgE), and interferon-gamma (IFN-γ) increased, whereas cluster of differentiation 8 positive (CD8) decreased in both groups. The observation group exhibited higher levels of CD3, CD4, CD4/CD8, IL-2, IL-6, IgE, and IFN-γ, and lower CD8 levels compared with the control group. Scores for all dimensions and total scores of the Dermatology Life Quality Index (DLQI) decreased after treatment in both groups, with significantly lower scores in the observation group. CONCLUSION: Interferon injection therapy demonstrates clinical efficacy in the treatment of common warts on the hands and feet.
VYC-17.5L is Safe and Effective in Improving Skin Quality and Volume Deficit of Hands: Results From an 18-Month Open-Label Study.
Greiner-Krüger D, Leys C, Lipko-Godlewska S … +3 more , Kerson GM, Chawla S, de la Guardia C
J Cosmet Dermatol · 2026 Feb · PMID 41693212 · Full text
BACKGROUND: Hands undergo age-related changes in volume and skin quality. This 18-month exploratory study evaluated safety and effectiveness of VYC-17.5 L for hand rejuvenation. METHODS: Participants (≥ 35 years) with mo...
BACKGROUND: Hands undergo age-related changes in volume and skin quality. This 18-month exploratory study evaluated safety and effectiveness of VYC-17.5 L for hand rejuvenation. METHODS: Participants (≥ 35 years) with moderate-to-extreme Allergan Hand Volume Deficit Scale (AHVDS) scores received VYC-17.5L in both hands on day 1, with optional touch-up on day 30. Effectiveness was assessed by AHVDS responder rate (≥ 1-grade improvement from baseline per hand) at months 1, 3 (primary effectiveness timepoint), and at 3-month intervals through month 18; investigator- and participant-Global Aesthetic Improvement Scale (GAIS); hand Self-Perception of Age (SPA); and skin quality measurements. Safety was evaluated throughout. RESULTS: Seventy-five participants (94.7% female; mean age, 53.89 years) had both hands injected with VYC-17.5L (median, 2.0 mL/hand), and 60.0% of hands received touch-up (median, 1.0 mL/hand). The primary endpoint was met: 100.0% of hands were AHVDS responders at month 3. The 100% response rate was maintained through month 6, and the majority of participants (> 65%) were responders through month 18. Most hands (≥ 85%) improved on investigator- and participant-GAIS through month 12. SPA improved by 5 to 6 years. Significant skin quality improvements persisted to 12 months. Twenty-two (29.3%) participants experienced treatment-related adverse events; most were mild or moderate in severity with a mean duration of 45.1 days, and none led to study discontinuation. CONCLUSION: VYC-17.5L is an effective treatment for improving hand volume deficit, with aesthetic benefits lasting 18 months.
A Novel 1726 Nm Laser Therapy for Durable Clearance of Seborrheic Dermatitis.
Al-Mamoori A, Daniel V, Al-Badri SG … +2 more , Khalil I, Al-Daraji W
J Cosmet Dermatol · 2026 Feb · PMID 41693211 · Full text
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Dermocosmetics in Acne Vulgaris: South African Consensus Recommendations With a Focus on Skin of Color.
Visser WI, Kannenberg SM, Prevost A … +4 more , Khoza N, Pillay L, Wiid KJ, Heydenrych IR
J Cosmet Dermatol · 2026 Feb · PMID 41689191 · Full text
BACKGROUND: Acne vulgaris is one of the most common dermatological disorders worldwide, affecting both adolescents and adults. It frequently leads to significant psychosocial and physical sequelae, including acne-induced...
BACKGROUND: Acne vulgaris is one of the most common dermatological disorders worldwide, affecting both adolescents and adults. It frequently leads to significant psychosocial and physical sequelae, including acne-induced hyperpigmentation and scarring. Beyond pharmaceutical therapies, dermocosmetics-topical formulations enriched with active ingredients in cosmetically elegant vehicles-have emerged as essential partners in acne management. They optimize clinical outcomes by supporting skin barrier repair, reducing irritation associated with conventional treatments, and targeting key pathogenic pathways in acne. However, no region-specific guidance exists to inform the effective use of dermocosmetics in South African patients, particularly those with skin of color. AIMS: To develop expert consensus recommendations for the use of dermocosmetics in acne vulgaris management within the South African context. METHODS: This consensus was developed through structured expert meetings and a targeted literature review of current international and local evidence. The panel synthesized clinical experience and research findings to identify key principles for selecting and integrating dermocosmetics into acne treatment regimens. RESULTS: The consensus highlights the multifaceted role of dermocosmetics in addressing core acne pathogenic factors, supporting epidermal barrier function, mitigating treatment-related adverse effects, and managing acne-induced hyperpigmentation in skin of color. Practical recommendations are provided for their use as adjunctive therapy, monotherapy in mild cases, and maintenance therapy to sustain remission. CONCLUSION: This South African consensus provides a practical, evidence-informed framework for incorporating dermocosmetics into acne management, with particular attention to the needs of patients with skin of color. Adoption of these recommendations may enhance treatment outcomes, adherence, and patient satisfaction across diverse skin types.
Efficacy of Microneedle Fractional Radiofrequency Combined With Platelet-Rich Plasma for the Treatment of Melasma: A Split-Face, Randomized Trial.
Chen Z, Li Y, Ou Y … +3 more , Chen T, Chen Y, Chen J
J Cosmet Dermatol · 2026 Feb · PMID 41689174 · Full text
BACKGROUND: Melasma is a common facial pigmentary disorder that markedly impairs quality of life, yet current treatments often yield incomplete clearance and frequent relapse. Microneedle fractional radiofrequency (MFR)...
BACKGROUND: Melasma is a common facial pigmentary disorder that markedly impairs quality of life, yet current treatments often yield incomplete clearance and frequent relapse. Microneedle fractional radiofrequency (MFR) can remodel the dermis and enhance transdermal delivery, whereas platelet-rich plasma (PRP) provides growth factors that may modulate melanogenesis and inflammation. AIMS: To compare the efficacy and safety of MFR combined with PRP versus MFR alone in the treatment of facial melasma. METHODS: In this prospective, randomized, evaluator-blinded, split-face trial, 30 patients with stable, symmetrical facial melasma received two sessions of MFR. One facial side was randomly assigned to receive adjunctive PRP and the contralateral side received saline. Outcomes included modified Melasma Area and Severity Index (mMASI) and hemi-mMASI scores, VISIA skin analysis, patient-reported satisfaction, and adverse events. Ultrasound was used to measure epidermal and dermal thickness at predefined facial landmarks. RESULTS: Twenty-nine patients completed the study. Overall mMASI and hemi-mMASI scores decreased on both sides at the 3-month follow-up after the last treatment. VISIA analysis showed significant reductions in red area and brown spot scores on the combination side, whereas changes on the MFR-alone side did not reach statistical significance. Ultrasound demonstrated increased dermal thickness at selected landmarks on each side, but the magnitude of change did not differ between sides. CONCLUSIONS: MFR is an effective and safe option for melasma in patients with Fitzpatrick skin types III-IV. Adjunctive PRP did not further improve global clinical pigment scores or ultrasound-detected structural changes, but may offer added benefit for erythematous and pigmentary features detected by VISIA.
Prospective Observational Study of Polynucleotide Injections for Periorbital Rhytides.
Ziade G, Keyrouz E, El Maalouf J … +4 more , Swaidan D, Karam D, Daou D, Fidawi G
J Cosmet Dermatol · 2026 Feb · PMID 41689167 · Full text
INTRODUCTION: Polynucleotides (PN), derived from salmon sperm DNA, are highly purified DNA fragments with reported tissue-repair and anti-inflammatory properties mediated through adenosine A2A receptor activation. These...
INTRODUCTION: Polynucleotides (PN), derived from salmon sperm DNA, are highly purified DNA fragments with reported tissue-repair and anti-inflammatory properties mediated through adenosine A2A receptor activation. These agents have been increasingly used in aesthetic dermatology for skin rejuvenation and scar treatment. This study aimed to evaluate longitudinal changes in periorbital appearance and patient-reported outcomes following intradermal polynucleotide injections. METHODS: This prospective observational case series included patients presenting for undereye rejuvenation who received intradermal injections of absorbable polynucleotides (7.5 mg/mL; Pluryal Silk, MD Skin Solutions, Luxembourg), with a total volume of 2 mL per session. Outcomes were assessed using validated FACE-Q patient-reported questionnaires at baseline and at 1, 3, and 6 months following treatment. Adverse events were assessed 2 days after each treatment session. Statistical analysis was performed using paired t-tests. RESULTS: Forty-two patients were included. Significant improvements in lower eyelid and crow's feet appraisal scores were observed at all follow-up time points compared with baseline (p < 0.001). The greatest improvements and highest patient satisfaction were observed at 3 months following two treatment sessions. Reported adverse events were minimal. CONCLUSION: In this prospective observational cohort, intradermal polynucleotide injections were associated with improvements in periorbital appearance and patient-reported satisfaction over baseline, with minimal adverse events. These findings support further controlled studies to confirm efficacy and refine treatment protocols.
Truncal Acne: Pathophysiology, Clinical Features, and Management Strategies.
Feng X, Chen Y, Liu Y
J Cosmet Dermatol · 2026 Feb · PMID 41689165 · Full text
BACKGROUND: Truncal acne is common but underrecognized. Its pathogenesis is often considered similar to facial acne, so most studies and guidelines focus on facial involvement despite the substantial disease burden of tr...
BACKGROUND: Truncal acne is common but underrecognized. Its pathogenesis is often considered similar to facial acne, so most studies and guidelines focus on facial involvement despite the substantial disease burden of truncal lesions. OBJECTIVE: This narrative review compares structural and physiological differences between truncal and facial skin, evaluates their impact on acne pathogenesis, and analyzes advantages and limitations of topical and systemic therapies, highlighting the role of routine skincare. METHODS: PubMed and Google Scholar were searched for English-language articles published up to December 2025 using keywords with Boolean operators. Evidence was narratively synthesized, and major study limitations were summarized. RESULTS: Truncal skin has a thicker stratum corneum, lower sebaceous gland density and activity, and site-specific differences in pH, sweat gland distribution, and microbiota, influenced by clothing occlusion and friction. These features are associated with deeper, more extensive lesions. Topical absorption may be limited and adherence reduced, while systemic treatments require careful balancing of efficacy and safety. Routine skincare may reduce adverse effects, improve adherence, and enhance topical outcomes. CONCLUSION: Management should consider skin-specific differences. Clinicians should assess truncal involvement and select formulations that optimize permeability and usability. Future research should clarify truncal-specific mechanisms and guide development of combination therapies and optimized topical formulations.
New Cellular Treatment Factor (NCTF) and Polydeoxyribonucleotide (VAMP) Injections Enhance Skin Regeneration: Experimental and Histological Evidence.
Adel N, Kolenda J
J Cosmet Dermatol · 2026 Feb · PMID 41674119 · Full text
BACKGROUND: Optimizing cutaneous wound healing remains a priority in dermatology and plastic surgery. Bioactive injectables such as NCTF and VAMP are gaining interest for their potential to enhance angiogenesis and tissu...
BACKGROUND: Optimizing cutaneous wound healing remains a priority in dermatology and plastic surgery. Bioactive injectables such as NCTF and VAMP are gaining interest for their potential to enhance angiogenesis and tissue regeneration, yet their combined effects remain underexplored. OBJECTIVE: To compare the effects of NCTF, VAMP, and their combination on full thickness skin wound healing in an experimental hamster model, using histological and immunohistochemical analyses. METHODS: One hundred forty-four adult hamsters were randomly assigned to four groups: (1) control (full thickness 2 cm length & 2 mm width dorsal incision, no injection), (2) NCTF (0.1 mL), (3) VAMP (0.1 mL), and (4) combined NCTF + VAMP (0.05 mL each). Wounds were evaluated at baseline, day 3, day 7, and day 14. Tissue samples underwent hematoxylin-eosin (HE) and Masson's trichrome (MT) staining for histological assessment, and immunohistochemical staining for CD34 was performed to evaluate angiogenesis and capillary density. RESULTS: All treatment groups showed faster wound closure, greater collagen deposition, and higher microvessel density than controls. The combination therapy produced the most pronounced improvements, followed by NCTF alone, then VAMP alone, with the control group showing the slowest healing. CD34 positive capillary density and collagen fiber alignment were significantly superior in the combination group at days 7 and 14 (p < 0.05). CONCLUSION: NCTF and VAMP both enhance full thickness skin wound healing, with the combination achieving the greatest histological and angiogenic improvements. These findings pertain to early and intermediate phases of wound healing (up to 14 days) and suggest potential benefit of combination therapy, pending further studies in larger animal models and clinical trials.
Thermal Accumulation and Collagen Remodeling in Porcine Models: Parameter-Dependent Efficacy of Micro-Focused Ultrasound for Human Facial Skin Tightening.
Qi J, Wei B, Pan J … +1 more , Zhang H
J Cosmet Dermatol · 2026 Feb · PMID 41673956 · Full text
BACKGROUND: Skin laxity, driven by collagen/elastin degradation and aging, is targeted by micro-focused ultrasound (MFU) through depth-specific thermal coagulation to induce collagen remodeling, yet parameter-dependent t...
BACKGROUND: Skin laxity, driven by collagen/elastin degradation and aging, is targeted by micro-focused ultrasound (MFU) through depth-specific thermal coagulation to induce collagen remodeling, yet parameter-dependent thermal kinetics and safety thresholds remain underexplored, limiting protocol optimization. AIMS: To validate the dose-effect relationship of MFU using in vitro porcine skin tissues and evaluate its safety and efficacy for human facial skin tightening. METHODS: Porcine skin tissues containing intact skin, fat, and muscle layers were treated with 8D-DL 3.0, 8D-DL 4.5, Vmax-DL 3.0, and Vmax-DL 4.5 handpieces. Subcutaneous temperatures at depths of 2.0 mm, 3.0 mm, 4.5 mm, and 6.0 mm were recorded under varying parameters (energy levels and exposure durations). Twenty patients undergoing single-session MFU facial treatment between June and August 2024 were enrolled. Skin tightening outcomes were assessed at 30- and 90-days post-treatment. RESULTS: For 8D-DL 3.0 and Vmax-DL 3.0 handpieces, peak temperatures occurred at 3.0 mm depth across all energy levels and exposure durations. For 8D-DL 4.5 and Vmax-DL 4.5 handpieces, peak temperatures localized at 4.5 mm. Focal depth temperatures increased significantly with higher energy levels and prolonged exposure. At 30- and 90-days post-treatment, upward displacement and volume reduction in bilateral cheek and jawline regions were observed. Mild procedural pain was reported, with no adverse events. CONCLUSION: MFU-induced thermal peaks align with preset focal depths, demonstrating parameter-dependent thermal accumulation. The procedure safely achieves clinically significant facial skin tightening.
Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split-Hand, Randomized, Double-Blind Clinical and In Vitro Study.
Faria GEL, Hasmann C, Viana RMM … +7 more , Machado ACHR, de Oliveira BD, Medina RIS, Filho AC, Zattar L, Machado-Santelli GM, Boggio RF
J Cosmet Dermatol · 2026 Feb · PMID 41669823 · Full text
BACKGROUND: Calcium hydroxyapatite (CaHA) is a well-established biostimulatory filler approved for hand rejuvenation. Recent approaches have explored dilution with polymicronutrient (PMN) solutions to enhance cellular me...
BACKGROUND: Calcium hydroxyapatite (CaHA) is a well-established biostimulatory filler approved for hand rejuvenation. Recent approaches have explored dilution with polymicronutrient (PMN) solutions to enhance cellular metabolism and extracellular matrix (ECM) regeneration. AIMS: To evaluate the biological and clinical effects of CaHA diluted in a PMN solution (CaHA + PMN) compared with the conventional CaHA diluted in saline solution (CaHA + SS) for hand rejuvenation. METHODS: An in vitro study was conducted to assess fibroblast proliferation and gene expression of ECM components (COL1A1, COL3A1, and ELN) after exposure to CaHA diluted with PMN or SS. A prospective, split-hand, double-blind clinical trial (n = 22) compared both formulations regarding Hand Grading Scale (HGS), Global Aesthetic Improvement Scale (GAIS), skin hydration (corneometry), and dermal thickness (ultrasound imaging) at baseline, 15 and 90 days after treatment. RESULTS: In vitro, CaHA + PMN induced greater fibroblast proliferation and upregulated COL1A1 and ELN gene expression compared to CaHA + SS. Clinically, both treatments led to significant improvement from baseline in HGS (p < 0.001), skin hydration and dermal/hypodermal thickness, with no statistically significant differences between-group. Investigator-assessed GAIS and patient-reported satisfaction on a 5-point Likert scale also showed improvement in both groups. CONCLUSION: Both treatments demonstrated comparable clinical outcomes, suggesting that the strong biostimulating effect of CaHA may have overshadowed potential additive effects of PMN. Nonetheless, in vitro findings confirmed enhanced biological activity with CaHA + PMN, supporting its investigation as a complementary strategy in future studies.
Atopic Dermatitis Accelerates Skin Physiological Functional Decline and Visible Aging, Suppressed by Skincare Habits.
Kikuchi K, Murakami Y, Sato H … +8 more , Yamashita R, Saya Y, Uchino R, Sugita T, Shinkai Y, Takahara Y, Shingaki K, Matsunaka H
J Cosmet Dermatol · 2026 Feb · PMID 41668302 · Full text
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disorder that causes barrier dysfunction and chronic itching; patients exhibit more obvious age-related external changes than healthy individuals. Detailed compa...
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disorder that causes barrier dysfunction and chronic itching; patients exhibit more obvious age-related external changes than healthy individuals. Detailed comparative investigations of patients with AD and healthy individuals are lacking, including visible age, skin physiological function, and inflammatory and immune factors in the stratum corneum. AIMS: To investigate the skin physiological function, physiologically active substances in the stratum corneum, and visible age of patients with AD and healthy controls (HCs), and to verify the effects of skincare habits. METHODS: This study was conducted from November to December 2023 and included male and female patients with AD and HCs aged 20-50 years. Skincare habits were assessed using a questionnaire, physiological function by device measurements, physiologically active substances using multiplex analysis, and visible aging by comparison with age- and sex-matched patients with AD and HCs. RESULTS: Compared with those in the HC group, the cheek skin of the AD group was darker, had a higher melanin index, lower stratum corneum water content, higher transepidermal water loss, higher levels of inflammatory and immune factors in the stratum corneum, and less sebum on the forehead skin surface. Additionally, the AD group appeared older than their age-matched HC group. However, skincare habits improved these changes, with no significant difference between the HC and AD groups following skincare habits. CONCLUSIONS: Skincare habits can suppress AD-associated changes in the physiological function of the skin, inflammatory and immune factors in the stratum corneum, and visible aging.
Foreign Body Granuloma and Infection-Related Complications Arising From Acupoint Embedding: A Case Study and Literature Review.
Xu X, Song K, Shen Y … +2 more , Jang C, Hong S
J Cosmet Dermatol · 2026 Feb · PMID 41664559 · Full text
BACKGROUND: Acupoint embedding (AEM) therapy merges traditional acupuncture with modern biomaterials to treat various diseases and for cosmetic uses, especially obesity and facial anti-aging. RESEARCH OBJECTIVE: To exami...
BACKGROUND: Acupoint embedding (AEM) therapy merges traditional acupuncture with modern biomaterials to treat various diseases and for cosmetic uses, especially obesity and facial anti-aging. RESEARCH OBJECTIVE: To examine complications from acupuncture embedding therapy (AEM), focusing on foreign body granulomas and infections. The study reviews cases to understand their causes, symptoms, diagnosis, treatment, and prevention, aiming to offer new treatment options for granulomas from acupuncture. METHODS: Using PRISMA guidelines, a literature search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library with keywords related to thread embedding acupuncture and its adverse effects, covering 2014-2024. Nine articles were included, along with a 2023 case report of a woman developing a granuloma after collagen thread acupuncture for weight loss. RESULTS: Among the 11 cases of complications following acupuncture point thread implantation, foreign body granuloma accounted for 90.91%, making it the most prevalent type of complication associated with this therapy. This case report details a treatment involving antibiotics to reduce exudate, steroids to shrink the mass, and later, a combination of warm acupuncture and radiation therapy to further reduce the nodule. However, surgical treatment yields the most significant therapeutic effect for foreign body granulomas. CONCLUSION: Animal-derived sutures, like catgut, often cause foreign body granulomas quickly. If these granulomas resist treatments like steroids or antibiotics, surgery is the best option. Clinicians must recognize the high risk of granulomas and prioritize using biocompatible sutures, maintaining aseptic techniques, ensuring precise suture placement, and closely monitoring patients post-surgery. For small early-stage nodules, consider medication and warm acupuncture. For stubborn or larger lesions, prompt surgery is vital to reduce complications and improve outcomes.
Injectables and Facelifts: Can We Coexist? A Retrospective Chart Review Assessing Injectable Treatments Preceding and Following Rhytidectomy.
Myers B, Firsowicz M, Kamrani P … +2 more , Dayan S, Fabi S
J Cosmet Dermatol · 2026 Feb · PMID 41664552 · Full text
BACKGROUND: Facelift surgery is a cornerstone of facial rejuvenation, yet it may not fully address volume loss, skin quality, or other age-related changes. Minimally invasive procedures-such as injectables and energy-bas...
BACKGROUND: Facelift surgery is a cornerstone of facial rejuvenation, yet it may not fully address volume loss, skin quality, or other age-related changes. Minimally invasive procedures-such as injectables and energy-based devices-are increasingly utilized before and after facelift surgery, though their impact on surgical outcomes remains uncertain. OBJECTIVE: The objective of this single-center retrospective pilot study is to describe patterns of minimally invasive procedures among patients undergoing facelift surgery in a real-world clinical setting and identify areas for future investigations regarding their potential influence on surgical outcomes. METHODS: We analyzed data from 20 patients who underwent facelift surgery and had a documented history of neurotoxin, filler, biostimulator, or energy-based device treatment. Data included patient demographics, treatment history, surgical details, and post-operative satisfaction. Given the limited sample size and retrospective design, the analyses done were descriptive and exploratory in nature. RESULTS: All patients received neurotoxin prior to facelift, 90% received hyaluronic-acid filler, and 55% received poly-L-lactic acid or calcium hydroxylapatite. Following surgery, all patients resumed neurotoxin use, and 60% received filler treatments within the first post-operative year. No reported significant surgical complications occurred because of prior filler or biostimulator treatments, and patient satisfaction was high for facelift outcomes. CONCLUSION: Within our small, retrospective cohort, prior injectable or energy-based device use was not associated with an increased risk of observable adverse surgical outcomes; however, the limited sample size precludes definitive assessment of safety or risk. Larger, prospectively designed studies are warranted to validate these early observations and optimally define best practices for combining surgical and nonsurgical rejuvenation.
Excited Skin Syndrome (Angry Back), What Do We Know About It? A Review of the Literature.
Beyzaee AM, Maibach HI
J Cosmet Dermatol · 2026 Feb · PMID 41664523 · Full text
BACKGROUND: In 1975, Mitchell brought up a theory that false positive reactions can be due to skin hyperirritability, called it "angry back syndrome" (ABS). The phenomenon is observed in patch testing of patients with se...
BACKGROUND: In 1975, Mitchell brought up a theory that false positive reactions can be due to skin hyperirritability, called it "angry back syndrome" (ABS). The phenomenon is observed in patch testing of patients with several positive patch tests, mostly along with one or more strong reactions. Later, Maibach rephrased ABS to "excited skin syndrome" (ESS) because of generalized involvement of the skin, not only the back. AIMS: In this paper, we tried to analyze the possible ESS-related mechanisms and provide crucial information on how to deal with a suspected patient. METHODS: On July 2024, we made a wide systematic computer-assisted search of PubMed and Google Scholar (Embase, Scopus) data base, using "excited skin syndrome" and "angry back syndrome" keywords. We scanned 350 studies. After removing duplicate studies, 31 studies concerning ESS/ABS were included in our review. RESULTS: Patch test results with more than a positive reaction can be due to EES development, particularly when the reactions are non-relevant to the patient. Several factors can alter the chance of ESS including: positioning of the allergens during the patch testing procedure, poly-sensitization, eczema/dermatitis. CONCLUSIONS: We can consider the following points to manage ESS and minimize its occurrence chance: ESS should be suspected when multiple positive reactions are seen. In suspected cases of ESS, re-examining and re-taking history for any relevance of positive reactions is recommended. Retesting should be performed if positive reactions are clinically irrelevant. It is preferred to perform patch testing when no sign of dermatitis is present.
Glow Tech in Adult Female Acne: Preliminary Real-World Experience.
de Oliveira RRC
J Cosmet Dermatol · 2026 Feb · PMID 41664432 · Full text
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