Journal Of Cosmetic Dermatology[JOURNAL]
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200 papers
Improvement of Overall Skin Condition in Acne and Oily Prone Skin With an Amino Acid Cleanser Containing Salicylic Acid, Glucuronolactone, and Ceramides.
Ai Levin Y, Lyu Y, He X
J Cosmet Dermatol · 2026 Mar · PMID 41749022 · Full text
BACKGROUND: Cleansers and moisturizers are two of the most essential skincare categories, both of which have significant dermatological implications. However, most studies focus on the cleansing power of surfactants and...
BACKGROUND: Cleansers and moisturizers are two of the most essential skincare categories, both of which have significant dermatological implications. However, most studies focus on the cleansing power of surfactants and their potential damage to the skin barrier. Few studies explore the combined effects of surfactants and active ingredients on skin condition. OBJECTIVE: The main focus of this research was to explore the comprehensive improvement effects of a cleanser containing salicylic acid, glucuronolactone, and ceramides on acne and oily-prone skin. METHODS: A total of 42 volunteers used amino acid cleanser containing salicylic acid, glucuronolactone, and ceramides for 28 days. Noninvasive methods combined with dermatologist evaluation to detect skin barrier changes in TEWL, hydration, facial sebum content, acne counts, facial redness, and texture were used. Adverse reactions were also assessed. RESULTS: The results indicate that after continuous use for 4 weeks, there was a significant improvement in skin barrier function, redness, moisture content, and skin texture, while acne-related indicators also showed a significant reduction. No adverse events occurred during the entire testing process. CONCLUSION: In summary, an amino acid cleanser containing salicylic acid, glucuronolactone, and ceramides has anti-acne, repairing, soothing, and texture-improving properties, offering multidimensional improvement for acne and oily-prone skin conditions.
Reply to Correspondence: Needle Clogging in Biostimulator Injection: Rheological Context and Clinical Experience.
Radke F, Gärtner U, Seipp A … +2 more , Gorczyza M, Wüst S
J Cosmet Dermatol · 2026 Mar · PMID 41748919 · Full text
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A Split-Scar Study: Study of Surgical Scar Using Exosomes.
Jeong KH, Park KY, Jung DW
J Cosmet Dermatol · 2026 Mar · PMID 41748500 · Full text
BACKGROUND: Exosomes have emerged as a promising therapeutic agent for various dermatological conditions such as acne, atopic dermatitis, and wound healing. This study aims to evaluate exosome's efficacy in improving pos...
BACKGROUND: Exosomes have emerged as a promising therapeutic agent for various dermatological conditions such as acne, atopic dermatitis, and wound healing. This study aims to evaluate exosome's efficacy in improving postoperative scars. METHODS: Ten patients underwent revision rhinoplasty with autologous costal cartilage, each with a 3 cm anterior chest incision scar were enrolled. Scars (mean 4.3 months postoperatively) were divided into medial and lateral halves; one half was treated with ASC-Exosome (experimental) and the other with hyaluronic acid (control). Outcomes were assessed using the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS). RESULT: The experimental side treated with ASC-Exosome demonstrated improvements compared to the control side. Pigmentation improved significantly in the Observer Scar Assessment Scale (OSAS) group from week 3 onward, though no consistent changes were observed on the VSS. Pliability showed significant improvement in both OSAS and VSS, beginning at week 3 and persisting through week 8. Relief also improved in the OSAS group from weeks 4 to 8. While no vascularity differences were detected, one-year follow-up photographs confirmed superior improvements in scar height and thickness on the exosome-treated side. Patient Scar Assessment Scale (PSAS) indicated significant improvements in scar color by week 4, stiffness by week 3, and thickness by week 2. Irregularity showed significant differences at week 4 and week 8. No significant differences were noted in pain or itching between the sides. CONCLUSIONS: Exosomes significantly improved scar quality, particularly pigmentation, pliability, and relief, and can represent a valuable option for postoperative scar management.
Early Physiotherapy of Post-Surgical Scars Using a Topical Cannabidiol (VeroDol CBD) Cream Gel: Three Case Reports.
Coucourde D, Barattini DF
J Cosmet Dermatol · 2026 Mar · PMID 41744154 · Full text
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Does Lip Augmentation With Hyaluronic Acid Affect Lip Motricity in Young Patients?
Munoz-Lora VRM, Baseggio W, Roschel P … +6 more , Zillo L, Dias C, Carnevali ACN, Rogerio V, Pauletto P, Germani M
J Cosmet Dermatol · 2026 Mar · PMID 41742711 · Full text
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Comparative Evaluation of High-Frequency Microneedling Using a Layering Technique Versus Conventional Technique for Facial Rejuvenation.
Tang Y, Wu K, Song X … +3 more , Lu Z, Fan M, Qiao M
J Cosmet Dermatol · 2026 Mar · PMID 41742263 · Full text
OBJECTIVE: To evaluate the effectiveness of high-frequency microneedling (HFM) using a layering technique versus conventional HFM for facial rejuvenation, with the Fitzpatrick Wrinkle and Laxity Classification Scale (FWC...
OBJECTIVE: To evaluate the effectiveness of high-frequency microneedling (HFM) using a layering technique versus conventional HFM for facial rejuvenation, with the Fitzpatrick Wrinkle and Laxity Classification Scale (FWCS) score at 3 months post-treatment as the primary endpoint. METHODS: A prospective non-randomized controlled study was conducted on 30 patients undergoing facial rejuvenation at Changzhou TCM Hospital (January-December 2024), who were divided into two groups (n = 15 each). The conventional group received standard HFM, while the layered group received HFM with needle length, power, and pulse width adjusted for superficial, middle, and deep skin layers. The primary endpoint was the Fitzpatrick Wrinkle and Laxity Classification Scale (FWCS) score at 3 months post-treatment. Secondary endpoints included FWCS scores at 1 and 2 months, VISIA-derived skin texture/pore scores, Global Aesthetic Improvement Scale (GAIS) scores, Cutometer skin rebound rate, and patient satisfaction. Assessments were performed pre-treatment and at 1, 2, and 3 months post-treatment. Statistical analyses were conducted using SPSS 22.0, with linear mixed-effects models for repeated measures, ordinal methods for GAIS, and Fisher's exact test for satisfaction. RESULTS: Pre-treatment FWCS scores showed no significant difference (p > 0.05). At 1 month, the layering group showed a significantly greater FWCS score reduction (2.53 vs. 1.34, p < 0.05). FWCS scores remained significantly lower in the layering group at 2 and 3 months (p < 0.05). Skin texture improvement was significantly better maintained in the layering group at 2 and 3 months (p < 0.05). Pore improvement was significantly better in the layering group only at 3 months (p < 0.05). GAIS scores indicated significantly superior rejuvenation effects in the layering group (p < 0.001). Patient satisfaction was significantly higher in the layering group (93.33% vs. 60.00%, p < 0.05). No serious adverse reactions occurred; transient redness and mild discomfort resolved quickly in both groups. CONCLUSION: The HFM layering technique demonstrates superior efficacy over conventional HFM for facial rejuvenation, with more significant and sustained improvements in wrinkles, skin texture, pores, and elasticity, as well as higher patient satisfaction. Both techniques are safe, though the layered approach is associated with slightly longer downtime.
Melanin Metabolism: A Novel Oxidative Degradation Mechanism and Regulation by Hydrolyzed Conchiolin Protein.
Zhao X, Zeng H, Zhu L … +1 more , Gu L
J Cosmet Dermatol · 2026 Mar · PMID 41742231 · Full text
BACKGROUND: Most pharmacological depigmenting agents and cosmetic skin-brightening products achieve their effects by suppressing melanogenesis. However, the fate of melanin after melanosome transfer to keratinocytes-and...
BACKGROUND: Most pharmacological depigmenting agents and cosmetic skin-brightening products achieve their effects by suppressing melanogenesis. However, the fate of melanin after melanosome transfer to keratinocytes-and the mechanisms governing its intracellular clearance-remains insufficiently explored. AIMS: This study aimed to elucidate the intracellular mechanism of melanin degradation in keratinocytes and to establish a simplified and operable experimental strategy for evaluating melanin clearance beyond melanogenesis inhibition. METHODS: A simplified in vitro model was established in which human epidermal keratinocytes phagocytosed isolated melanosomes, allowing investigation of melanin degradation independent of melanocyte activity. In parallel, a cell-free oxidative system consisting of ferrous ions and hydrogen peroxide was employed to chemically induce hydroxyl radical-mediated melanin degradation. Lysosomal activity, intracellular oxidative status, hydroxyl radical (•OH) generation, melanin content, and pH dependence were assessed using fluorescence imaging and biochemical assays. RESULTS: Keratinocytes exhibited a two-step melanin degradation process involving lysosomal proteolysis followed by oxidative breakdown mediated by •OH. Treatment with hydrolyzed conchiolin protein (HCP) enhanced melanin degradation by promoting lysosomal activation and modulating intracellular oxidative conditions. Fluorescence imaging demonstrated partial colocalization of •OH signals with lysosomes and suggested alterations in lysosomal pH following HCP exposure. Chemical assays further revealed that alkaline conditions more effectively promoted hydroxyl radical-mediated melanin degradation. CONCLUSIONS: This study identifies an intracellular melanin degradation pathway operating within keratinocytes and presents a simplified experimental framework integrating cellular and cell-free models. HCP emerges as a modulator of lysosomal-oxidative pigment clearance, offering an alternative pigmentation control strategy beyond melanogenesis inhibition and supporting the development of skin-brightening approaches that preserve physiological pigment homeostasis.
A Single-Center, Open-Label Study to Evaluate the Efficacy and Tolerability of Retinal Encapsulated in a Novel Biomimetic Exosome in the Treatment of Mild-To-Moderate Facial Photodamage.
Gold MH, Enright KM, Ablon G … +7 more , Barbarino S, Chilukuri S, Day D, Goldberg DJ, Lain T, Shamban A, Schlesinger T
J Cosmet Dermatol · 2026 Mar · PMID 41735774 · Full text
BACKGROUND: Numerous retinoid-based skincare products are available over-the-counter for photodamaged and photoaged skin, but are associated with objective (e.g., erythema, dryness, flaking, edema) and subjective (e.g.,...
BACKGROUND: Numerous retinoid-based skincare products are available over-the-counter for photodamaged and photoaged skin, but are associated with objective (e.g., erythema, dryness, flaking, edema) and subjective (e.g., itching, tingling, stinging, burning) tolerability issues. A novel retinal formulation was developed using an engineered biomimetic vegan exosome as a delivery system. The formulation also contains proprietary and potent hyaluronic acid, as well as plant-based actives commonly used in traditional herbal medicines for their anti-inflammatory and antioxidant properties. AIMS: Evaluate the efficacy and tolerability of this biomimetic exosome-encapsulated retinal product for treatment of mild-to-moderate facial photodamage. PATIENTS/METHODS: Twenty females aged 35 to 65 years, with Fitzpatrick skin types I-VI, mild-to-moderate facial fine lines and wrinkles, and mild-to-moderate facial photodamage, were assessed at screening/baseline and weeks 2, 4, 8, and 12. Investigator- and participant-assessed evaluations were performed at each visit. The primary objective was to demonstrate a decrease in the appearance of fine lines and wrinkles, erythema, as well as a reduction of overall facial photodamage after a 12-week topical regimen. The secondary objective was to measure the frequency of adverse events throughout the study. RESULTS: Statistically significant improvements in erythema, skin tone, skin texture, and lines/wrinkles were observed at all follow-up visits, compared to baseline. At weeks 8 and 12, all participants (100%) displayed improvements in facial aesthetics. Most participants (19/20; 95.00%) were satisfied with the product and would recommend it to others. No product-related adverse events were reported. CONCLUSIONS: Daily use of this "hydrating retinal" improved signs of facial photodamage with none to mild signs of skin irritation.
Exploration of the Therapeutic Protocols and Underlying Molecular Mechanisms of Autologous Platelet-Rich Plasma in the Treatment of Deep Second-Degree Burns.
Shi JG, Liu W, Liu HQ … +3 more , Rao D, Huang JW, Zhao YF
J Cosmet Dermatol · 2026 Mar · PMID 41738446 · Full text
BACKGROUND: Platelet-rich plasma (PRP) has been widely applied in burn wound management due to its high concentration of bioactive growth factors. However, inconsistent clinical outcomes and the lack of standardized prot...
BACKGROUND: Platelet-rich plasma (PRP) has been widely applied in burn wound management due to its high concentration of bioactive growth factors. However, inconsistent clinical outcomes and the lack of standardized protocols regarding timing, frequency, and leukocyte content limit its broader clinical adoption. AIMS: This study aimed to evaluate the therapeutic efficacy of PRP under different application protocols in patients with deep second-degree burns and to explore the underlying molecular mechanisms, with the goal of informing standardized, evidence-based PRP treatment strategies. PATIENTS/METHODS: Thirty-three patients with deep second-degree burns were enrolled and randomly assigned to five groups: a standard PRP group, a saline control group, an early intervention PRP group, a high-frequency PRP group, and a leukocyte-poor PRP group. Clinical outcomes included wound healing time, wound coverage rates at 2 and 3 weeks, bacterial culture positivity, and Vancouver Scar Scale scores at 3 months. Wound tissue and exudate samples were collected at predefined time points for immunohistochemical analysis of macrophage phenotypes (M1/M2) and quantification of growth factors (VEGF, PDGF, TGF-β). RESULTS: Compared with the control group, PRP treatment was associated with a shorter wound healing time, increased early wound coverage, reduced bacterial culture positivity, and improved scar outcomes. Early PRP intervention and the use of leukocyte-poor PRP appeared to further enhance healing efficiency, which may be related to accelerated polarization of macrophages from the pro-inflammatory M1 phenotype toward the anti-inflammatory M2 phenotype. In contrast, high-frequency PRP administration resulted in higher local growth factor levels but did not translate into additional clinical benefit; this lack of efficacy may be attributable to excessive expression of transforming growth factor-β (TGF-β), which could potentially counteract optimal tissue repair. CONCLUSIONS: PRP is an effective adjunctive therapy for small-area deep second-degree burns. Early application and leukocyte-poor PRP appear optimal, whereas indiscriminately increasing treatment frequency is not recommended. Controlled modulation of PRP-derived growth factors may be key to maximizing therapeutic benefit.
Fractional Microneedling Radiofrequency for Hidradenitis Suppurativa: A Real-World Retrospective Study Demonstrating Clinical Efficacy and Safety Across Diverse Anatomical Sites.
Safir A, Taleb E, Berzin D … +5 more , Arieli M, Liassidou A, Shehadeh W, Hafner A, Artzi O
J Cosmet Dermatol · 2026 Mar · PMID 41732823 · Full text
BACKGROUND: Hidradenitis suppurativa (HS) remains a therapeutically challenging disease despite expanding research and evolving systemic treatments. Energy-based modalities, such as fractional microneedling radiofrequenc...
BACKGROUND: Hidradenitis suppurativa (HS) remains a therapeutically challenging disease despite expanding research and evolving systemic treatments. Energy-based modalities, such as fractional microneedling radiofrequency (FMR), are being increasingly explored as novel treatment options. AIM: To evaluate the real-world efficacy and safety of Morpheus8-based FMR treatment in patients with HS. MATERIALS AND METHODS: This retrospective analysis included 25 HS patients treated at a tertiary dermatology center. Seventeen patients who completed ≥ 2 FMR sessions were included in the efficacy analysis. Outcomes were assessed by the International Hidradenitis Suppurativa Severity Score System (IHS4) and IHS4-55 (≥ 55% reduction). High-frequency ultrasound (HFUS) was used in selected cases to assess treatment response and inflammatory changes. RESULTS: Sixteen of the 17 patients (94.1%) evaluated for efficacy showed clinical improvement, and nine (52.9%) achieved an IHS4-55 response. The mean IHS4 reduction was 4.6 ± 2.5. The highest response rates were observed in the face, chest, and gluteal regions, while groin and thigh showed the lowest. HFUS confirmed a reduction in inflammation. Treatment was generally well tolerated, with pain cited as the most common reason for discontinuation in 3 of 25 patients (12%). CONCLUSION: FMR appears to be a safe and effective treatment option for patients with moderate-to-severe HS, including those with refractory disease and lesions in anatomically challenging areas. Clinical outcomes in our cohort were comparable to those reported for advanced systemic agents and other technology-based interventions. These findings support FMR's potential role in personalized HS management - either as a standalone intervention or in combination with systemic or procedural treatments.
The Bullhorn and Beyond: Evidence-Based Review and Clinical Recommendations for Lip Lift Techniques.
Komisarek O, Banasiak Ł, Olichwer V … +1 more , Burduk P
J Cosmet Dermatol · 2026 Mar · PMID 41731334 · Full text
BACKGROUND: The upper lip plays a central role in facial harmony and youthful appearance. Aging-related changes include elongation of the philtrum, thinning of the vermilion, and reduced maxillary incisor show. Surgical...
BACKGROUND: The upper lip plays a central role in facial harmony and youthful appearance. Aging-related changes include elongation of the philtrum, thinning of the vermilion, and reduced maxillary incisor show. Surgical lip lift shortens the cutaneous upper lip and enhances vermilion exposure, yet patient selection and outcome assessment remain non-standardized. OBJECTIVES: To critically evaluate current evidence on surgical lip lift techniques, including the classical subnasal bullhorn approach and its modifications, and to provide evidence-based recommendations for anatomy-driven technique selection. METHODS: A PRISMA 2020-compliant systematic review was conducted, with protocol registration in PROSPERO. Studies included adult patients (≥ 18 years) undergoing lip lift for aesthetic or aesthetic-functional indications. Prospective and retrospective clinical studies and case series (≥ 5 patients) published between 2017 and 2025 were identified through database searches. Data extraction focused on surgical technique, morphometric outcomes, patient satisfaction, and complications. Meta-analysis was not feasible due to heterogeneity. Methodological quality was assessed using the MINORS instrument and JBI checklists. RESULTS: Seven studies comprising 1754 patients were included. Subnasal bullhorn techniques and their modifications reduced philtral length from 14.0-14.5 mm to 10.8-12.0 mm, increased vermilion height from 5.0-6.0 mm to 7.0-9.0 mm, and improved maxillary incisor show from 1.5-2.0 mm to 3.5-5.0 mm. Patient satisfaction was high (mean GAIS score 4.4/5). Complications were predominantly mild and transient, with revision rates of 0.6%-6.7%. Overall study quality was moderate. CONCLUSIONS: Surgical lip lift is a safe and effective procedure for restoring upper-lip proportions. Technique selection should be individualized, and further prospective studies with standardized outcome measures are needed. TRIAL REGISTRATION: CRD420251232005.
Effects of Autologous Blood-Derived Extracellular Vesicles on Skin Regeneration and Anti-Aging: A Clinical Study.
Song J, Zhao C
J Cosmet Dermatol · 2026 Mar · PMID 41725041 · Full text
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Punch Excision Combined With Radiotherapy for Keloid Treatment.
Guan Y, Huang M
J Cosmet Dermatol · 2026 Mar · PMID 41725029 · Full text
BACKGROUND: Punch excision is gaining recognition in keloid management. Its distinct mechanism from conventional surgery necessitates a re-evaluation of the efficacy and safety when combined with radiotherapy (RT), an ar...
BACKGROUND: Punch excision is gaining recognition in keloid management. Its distinct mechanism from conventional surgery necessitates a re-evaluation of the efficacy and safety when combined with radiotherapy (RT), an area currently lacking evidence. AIMS: To investigate the clinical efficacy and safety of punch excision combined with RT for treating trunk keloids and to compare the differences between perioperative (RT initiated one day before surgery) and postoperative RT (RT within 24 h after surgery) regimens. METHODS: A retrospective study was conducted on patients with trunk keloids treated with punch excision combined with electron beam RT from January 2022 to January 2024. Outcomes were assessed using the Patient and Observer Scar Assessment Scale (POSAS) and records of adverse reactions. RESULTS: The study included 34 patients. At 18 months, all keloids improved significantly without recurrence. The total Observer Scale score decreased by 52.73% and the Patient Scale score by 62.77%. No significant difference in POSAS scores was found between the two groups at 18 months. The perioperative group showed advantages in shorter postoperative bleeding duration and lower incidence of moderate-to-severe acute pain. CONCLUSION: Punch excision combined with RT is effective for trunk keloids. While long-term cosmetic outcomes are similar between perioperative and postoperative RT, the perioperative regimen offers benefits in reducing early postoperative complications.
Exploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma.
Dhaliwal S, Dhanoa N, Rashid Z
J Cosmet Dermatol · 2026 Mar · PMID 41725026 · Full text
BACKGROUND: Melasma is a chronic pigment disorder associated with significant psychosocial burden. The gold standard triple combination cream is effective but limited by relapse and adverse effects. Tranexamic acid (TXA)...
BACKGROUND: Melasma is a chronic pigment disorder associated with significant psychosocial burden. The gold standard triple combination cream is effective but limited by relapse and adverse effects. Tranexamic acid (TXA) and microneedling have independently shown promise in the treatment of melasma, and their combined use may provide enhanced efficacy, durability, and tolerability. AIMS: This review aims to synthesize and compare clinical evidence assessing the effectiveness, safety, patient satisfaction, and durability of microneedling-based TXA for the treatment of melasma. METHODS: A PubMed search was performed for relevant studies published in the last 10 years. Eligible articles included clinical trials, observational studies, and case reports. A scoping literature review was then conducted to synthesize relevant findings. RESULTS: Most identified studies demonstrated improvement in melasma scores when TXA was delivered through microneedling. Outcomes are comparable to other TXA delivery methods and adjunctive therapies, with microneedling providing potential advantages in satisfaction, tolerability, and durability. These findings support its consideration for patients unable to tolerate systemic TXA or those seeking minimally invasive alternatives to laser-based treatments. CONCLUSION: This review compares microneedling-based TXA delivery with other treatment approaches, highlighting patient-centered advantages in tolerability and durability that may inform individualized treatment selection. Future studies should address limitations in protocol heterogeneity, reliance on semi-objective outcome measures, and limited long-term follow-up. Particular focus is needed on evaluating patients with skin of color, who may be more susceptible to post-inflammatory hyperpigmentation.
Comment on: Efficacy of Platelet-Rich Plasma Therapy in Melasma Using Microinjections and Microneedling Techniques.
Wang D, Chen Y, Han Z
J Cosmet Dermatol · 2026 Mar · PMID 41724993 · Full text
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Efficacy and Safety of Amino Acid-Enriched Hyaluronic Acid in Facial Rejuvenation: A Systematic Review and Meta-Analysis.
Mosteirin M, Ardila AG, Calomarde RG … +1 more , Mariscal G
J Cosmet Dermatol · 2026 Mar · PMID 41724989 · Full text
INTRODUCTION: Skin aging, marked by wrinkles, volume loss, and reduced hydration, has driven growing interest in minimally invasive aesthetic treatments to restore skin quality and appearance. This study aimed to evaluat...
INTRODUCTION: Skin aging, marked by wrinkles, volume loss, and reduced hydration, has driven growing interest in minimally invasive aesthetic treatments to restore skin quality and appearance. This study aimed to evaluate the efficacy and safety of an injectable formulation combining hyaluronic acid (HA) and amino acids (AA) for facial rejuvenation in adults. METHODS: A systematic review and meta-analysis was conducted according to the PRISMA guidelines using PubMed, EMBASE, Scopus, and the Cochrane Library. Eligible studies compared HA + AA complexes with conventional HA or a placebo. The primary efficacy outcomes were changes in wrinkle severity (WSRS), aesthetic improvement (GAIS), skin thickness, and epidermal growth factor (EGF)-positive cell viability. Safety was assessed by adverse event reporting. RESULTS: This meta-analysis included 11 studies that met the inclusion criteria. A significant reduction in wrinkle severity was observed on WSRS following treatment (MD, 2.15; 95% CI, 2.00-2.30; p < 0.0001). Global aesthetic improvement demonstrated a marked enhancement at 3 months (MD = 3.13; 95% CI = 1.94-4.33; p < 0.00001). Dermal thickness significantly increased post-treatment (MD = -0.42 mm; 95% CI = -0.55 to -0.30; p < 0.00001). Cell viability improved significantly (MD = -24.00; 95% CI = -25.16 to -22.84; p < 0.00001). There was a statistically significant difference in adverse events (RR = 5.20; 95% CI = 0.53-50.77; p = 0.16). CONCLUSION: Amino acid-enriched hyaluronic acid improves wrinkle severity, dermal thickness, and cell viability, enhancing overall skin aesthetics. Larger prospective studies are needed to confirm these findings.
Single-Entry-Point Thread Implantation Technique Using the Gerbera Pattern for Facial Skin Rejuvenation: A Prospective Intraindividual Controlled Clinical Study.
Huân MH
J Cosmet Dermatol · 2026 Feb · PMID 41715964 · Full text
BACKGROUND: Mono and screw threads are increasingly used for facial skin rejuvenation. However, most currently described techniques rely on multiple skin entry points, which may increase procedural pain and negatively af...
BACKGROUND: Mono and screw threads are increasingly used for facial skin rejuvenation. However, most currently described techniques rely on multiple skin entry points, which may increase procedural pain and negatively affect patient tolerability. OBJECTIVE: To describe a single-entry-point thread implantation technique using the Gerbera pattern and to evaluate pain at needle penetration compared with a conventional multiple-entry-point technique in a prospective intraindividual controlled clinical study. METHODS: This study included 20 adult female patients with mild-to-moderate facial skin aging. In paired facial regions (cheeks, malar areas, jawline, and temples), one side of the face was treated using the single-entry-point technique, while the contralateral side was treated using a conventional multiple-entry-point technique. Central regions (mid-forehead and mid-chin) were treated using shared modules due to anatomical considerations. Pain at needle penetration was assessed using a Visual Analogue Scale (VAS, 0-10). RESULTS: All 20 patients completed the procedure on the side treated with the single-entry-point technique. Two patients discontinued the procedure early on the multiple-entry-point side due to pain but completed treatment on the single-entry-point side. Pain scores at needle penetration were markedly lower with the single-entry-point technique than with the multiple-entry-point technique. No serious adverse events were observed. CONCLUSION: The single-entry-point thread implantation technique using the Gerbera pattern significantly reduced pain at needle penetration compared with the conventional multiple-entry-point technique, demonstrating good tolerability in clinical practice.
Ultrastructural Analysis of In Vitro Glycated Engineered Skin.
Denman K, Iberi V, Roiter Y … +4 more , Ammon M, Fang B, Ranatunga R, Agarwal G
J Cosmet Dermatol · 2026 Feb · PMID 41715905 · Full text
BACKGROUND: Aging of the human skin results in undesirable physical properties such as wrinkles, yellowing, and loss of luster. Advanced glycation end-products (AGEs) are understood to be one of the primary causes for th...
BACKGROUND: Aging of the human skin results in undesirable physical properties such as wrinkles, yellowing, and loss of luster. Advanced glycation end-products (AGEs) are understood to be one of the primary causes for these effects as assessed from studies on human skin subjected to in vivo or in vitro mediated glycation. Models to recapitulate the effect of skin-glycation in vitro are an active area of interest to understand and mitigate these effects. In this regard, engineered skin models have utilized pre-glycated collagen to assemble a glycated skin layer. However, this method is time-consuming and can suffer from variability across samples. The objective of this study was to examine how in vitro glycation of an engineered skin model affects its material properties. MATERIALS AND METHODS: In this study we used a pre-engineered skin model (MatTek EpiDerm) and subjected it to in vitro glycation using glyceraldehyde. The changes in luminosity of the samples were characterized 48 h post-glycation. Immunohistochemistry using an anti-AGE antibody was performed to verify glycation of the samples. Scanning transmission electron microscopy (STEM) and atomic force microscopy (AFM) were used to assess the ultrastructure of the samples and evaluate their surface roughness, adhesion, and mechanical properties. RESULTS: Our results show that upon glycation the engineered skin had reduced luster, increased yellowing, disruption in cell and matrix morphology, increased roughness, and modulus. These effects are similar to those previously reported in both natural and engineered skin. CONCLUSIONS: Overall, the approach presented here serves as a quick and easy method to recapitulate the glycation induced effects in the model skin and can serve as a platform to evaluate the effect of skin-care products on mitigating these effects.
The Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and Cutibacterium acnes Colonization in Women With Oily Skin.
Ciozda A, Firlej E, Bartosińska J … +1 more , Raczkiewicz D
J Cosmet Dermatol · 2026 Feb · PMID 41715896 · Full text
BACKGROUND: Oily skin is characterized by excessive sebum production and increased activity of Cutibacterium acnes. AIMS: To evaluate the effects of mandelic acid exfoliation, microneedle mesotherapy with a sebum-regulat...
BACKGROUND: Oily skin is characterized by excessive sebum production and increased activity of Cutibacterium acnes. AIMS: To evaluate the effects of mandelic acid exfoliation, microneedle mesotherapy with a sebum-regulating ampoule, and combination therapy on skin parameters and C. acnes activity in women with oily skin. METHODS: Fifty-five women aged 18-47 were randomly assigned to three groups: microneedle mesotherapy (6 treatments), mandelic acid exfoliation (6 treatments), or combination therapy (3 exfoliations followed by 3 mesotherapy treatments). Skin hydration, sebum level, pH, and gloss were measured using an MPA Courage&Khazaka device. C. acnes activity was assessed indirectly by porphyrin fluorescence with a Visiopor device. Measurements were taken on the cheeks and in the T-zone before treatment (day 1), after three session (day 63), and after six sessions (day 126). RESULTS: Skin hydration increased significantly in all groups. Mesotherapy reduced sebum in the T-zone only after six treatments, while exfoliation reduced sebum mainly on the cheeks. Combination therapy resulted in the most extensive and stable sebum reduction in both areas. A temporary decrease in pH was observed after mesotherapy, with no pH changes after exfoliation or combination therapy. No significant changes in skin gloss were found. C. acnes colonization increased in the T-zone after mesotherapy, whereas exfoliation and combination therapy significantly reduced all colonization indices, with the strongest effect for combination therapy. CONCLUSIONS: Mandelic acid exfoliation and microneedle mesotherapy support regulation of sebaceous activity and epidermal barrier function. Combination therapy is therapeutically superior, providing optimal improvement in skin parameters and the most effective reduction of C. acnes activity.
Rheological and Physicochemical Properties of Hyaluronic Acid Fillers for Body Contouring: Clinical Implications and Anatomical Considerations.
Fontenete S, Alfertshofer M
J Cosmet Dermatol · 2026 Feb · PMID 41715300 · Full text
INTRODUCTION: The use of hyaluronic acid (HA) fillers is rising globally. Traditionally, the rheology of HA fillers has been subject to investigations for their use in facial soft tissues. Hitherto, there has been a sign...
INTRODUCTION: The use of hyaluronic acid (HA) fillers is rising globally. Traditionally, the rheology of HA fillers has been subject to investigations for their use in facial soft tissues. Hitherto, there has been a significant gap in understanding their rheologic properties in body applications. The requirements for body fillers are different from facial fillers as they are applied for larger volume deficits, and experience greater mechanical stress. This study aims to fill this gap by analyzing the physicochemical and rheological properties of HA body fillers to guide clinical practice. MATERIALS AND METHODS: Four commercially available HA-based body fillers were analyzed under standardized laboratory conditions. The physicochemical properties, including pH, osmolality, ion concentrations, clarity, and swelling factor, were assessed. Rheological properties, including storage modulus (G'), loss modulus (G″), complex modulus (G*), and tan delta (tan δ), were assessed between 0.1 and 1 Hz. RESULTS: The physicochemical analysis revealed no significant differences among the fillers, indicating uniform chemical stability. However, rheological analysis showed significant variations. Infini B Body exhibited the lowest G', G″, and G* values. In contrast, HYAcorp MLF1 and MLF2 displayed higher G' and G* values, indicating greater elasticity and stiffness. Consistent rankings between 0.1 and 1 Hz suggest stable mechanical performance under dynamic and sustained loading, supporting their suitability for high-load applications such as gluteal augmentation. CONCLUSION: Selecting HA body fillers based on their rheological properties is crucial for optimizing outcomes, particularly in body contouring procedures where mechanical demands differ from those of facial applications. Clinicians should tailor filler selection to the specific requirements of each body area. Further research is required to validate these findings in long-term clinical settings.
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