Journal Of Cosmetic Dermatology[JOURNAL]
Sun
200 papers
The Association of Acne Vulgaris and Disease Severity With Serum Amyloid A1 and Insulin Levels.
Hizli P, İçöz Aytaç S, Baykan Ö … +2 more , Öklü M, Kiliç FA
J Cosmet Dermatol · 2026 Mar · PMID 41814843 · Full text
BACKGROUND: Acne vulgaris is a chronic inflammatory disease involving multiple factors such as increased sebum production, follicular hyperkeratinization, microbial colonization, and inflammation. Serum amyloid A1 (SAA1)...
BACKGROUND: Acne vulgaris is a chronic inflammatory disease involving multiple factors such as increased sebum production, follicular hyperkeratinization, microbial colonization, and inflammation. Serum amyloid A1 (SAA1), an acute phase protein, and insulin, a hormone linked to metabolic and inflammatory pathways, may play significant roles in acne pathogenesis. OBJECTIVE: This study aimed to evaluate SAA1 and insulin levels in patients with acne vulgaris and to investigate their relationship with disease severity and scar formation. METHODS: A total of 72 acne vulgaris patients [13 males, 59 females; median age 22 (19-34) years] and 66 age-similar healthy controls [27 males, 39 females; median age 22 (18-38) years] were included. Acne severity was assessed using the Global Acne Grading System (GAGS), and scar severity was evaluated by the Global Scale for Acne Scar Severity. SAA1 and insulin levels were measured via ELISA from fasting blood samples. Additionally, anthropometric measurements and biochemical parameters were recorded. RESULTS: A total of 138 participants were included, with 72 acne vulgaris patients and 66 healthy controls. The groups were age-similar, though a higher female proportion was observed in the acne group. SAA1 levels were significantly higher in acne patients (p = 0.045), whereas insulin levels did not differ significantly (p = 0.902). LDL, triglycerides, and total cholesterol were significantly lower in the acne group (p = 0.003, p = 0.045, p = 0.023, respectively). SAA1 levels did not significantly correlate with acne severity (p = 0.052) or scar severity (p = 0.09). However, LDL and total cholesterol showed weak negative correlations with both acne severity and scar severity. CONCLUSION: Elevated SAA1 in acne vulgaris patients suggests that SAA1 may serve as a novel biomarker for assessing inflammation in acne. Further large-scale studies are needed to explore therapeutic implications targeting inflammation.
Impact of Ceramide Acyl Chain Length on Human Skin Barrier Recovery and Hydration.
Gwon DH, Choi HK, Lee EO … +4 more , Hong SK, Park CS, Kim JW, Liu KH
J Cosmet Dermatol · 2026 Mar · PMID 41814138 · Full text
OBJECTIVE: To compare the effects of ceramide acyl chain length on human skin barrier function. METHODS: Mixtures of phytoceramide containing non-hydroxy fatty acids (CER NPs) with different acyl chain lengths and corres...
OBJECTIVE: To compare the effects of ceramide acyl chain length on human skin barrier function. METHODS: Mixtures of phytoceramide containing non-hydroxy fatty acids (CER NPs) with different acyl chain lengths and corresponding test creams were prepared: C16-C24 CER NP and C24-C30 CER NP (ultra-long-chain, ULC CER NP). The content of C24 CER NP in these formulations was 0.3% and 39%, respectively. Liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis of skin ceramides was performed using tape-stripped human stratum corneum (SC) samples. A vehicle-controlled intra-subject human study was conducted to assess acute skin barrier recovery, skin hydration, and SC cohesion. RESULTS: Levels of C24 and C26 ceramides were significantly increased in skin treated with C24-C30 CER NP. These analytical results were consistent with the findings from the human efficacy study. Functional evaluations demonstrated that C24-C30 CER NP significantly enhanced barrier recovery, skin hydration, and SC cohesion compared with C18 CER NP, whereas the C16-C24 CER NP formulation primarily improved skin hydration. Overall, the C24-C30 CER NP formulation exhibited the strongest barrier-enhancing effects among the tested formulations. CONCLUSION: This study provides the first in vivo human evidence that ceramides with longer acyl chains confer superior improvements in skin barrier function compared with shorter-chain ceramides. These findings highlight the critical role of acyl chain length in ceramide-mediated barrier enhancement and support the rational design of ceramide-based formulations for optimized skin barrier restoration.
Evaluation of a 10% Urea Lotion for Xerosis: Clinical and Patient-Reported Outcomes From a Prospective Study.
Maletin N, Spasić B, Golušin Z … +8 more , Binić I, Nišavić M, Ranđelović M, Golubović M, Borocki S, Marin L, Binić I, Denda N
J Cosmet Dermatol · 2026 Mar · PMID 41807289 · Full text
INTRODUCTION: Xerosis cutis is a common skin condition characterized by dryness, scaling, and pruritus due to impaired barrier function and reduced natural moisturizing factors. This study aimed to evaluate the clinical...
INTRODUCTION: Xerosis cutis is a common skin condition characterized by dryness, scaling, and pruritus due to impaired barrier function and reduced natural moisturizing factors. This study aimed to evaluate the clinical efficacy of a 10% urea lotion in adults with xerosis and assess participant satisfaction with the product. METHODS: A prospective, single-arm clinical study was conducted over 60 days in adults with confirmed xerosis. Participants applied a 10% urea lotion with Prolom thermal water twice daily. Skin hydration and elasticity were measured by corneometry and cutometry at baseline, day 14, day 30, and day 60. Subjective outcomes were assessed using a product satisfaction questionnaire and the Skindex-16 scale. Data were analyzed using repeated measures ANOVA with p < 0.05 considered significant. RESULTS: Significant improvements were observed in skin hydration (+55.3%) and elasticity (+55%), as well as reductions in redness, scaling, and itching (all p < 0.001). Skindex-16 total scores improved by 61%, reflecting enhanced quality of life. The lotion was well tolerated, with no significant adverse effects, and participants reported high satisfaction and willingness to continue use. CONCLUSION: The 10% urea lotion with Prolom thermal water demonstrated significant clinical efficacy in improving hydration, elasticity, and overall skin condition in adults with xerosis over a 60-day period. The treatment was well tolerated and associated with high patient satisfaction and a marked improvement in quality of life.
Comprehensive Analysis of Free BDPE Content in Commercial Hyaluronic Acid Fillers: Implications for Safety Assessment and Regulatory Standards.
Kim CJ, Lee M, Park H … +5 more , Jo J, Lee H, Seo PJ, Shin SJ, Shin C
J Cosmet Dermatol · 2026 Mar · PMID 41804786 · Full text
BACKGROUND: Although manufacturers of 1,4-butanediol diglycidyl ether (BDDE)-cross-linked hyaluronic acid (HA) fillers assert effective removal of unreacted BDDE, the hydrolyzed derivative 3,3'-(butane-1,4-diyl)bis(oxy)b...
BACKGROUND: Although manufacturers of 1,4-butanediol diglycidyl ether (BDDE)-cross-linked hyaluronic acid (HA) fillers assert effective removal of unreacted BDDE, the hydrolyzed derivative 3,3'-(butane-1,4-diyl)bis(oxy)bis(propane-1,2-diol) (BDPE) is routinely monitored, despite possessing structural features associated with sensitization potential. AIMS: To quantify free BDPE content across commercially available HA dermal fillers and assess potential safety implications. MATERIALS/METHODS: A validated liquid chromatography-tandem mass spectrometry method was developed to quantify BDPE levels in 38 commercial HA filler products from seven major manufacturers. In silico prediction models were used to evaluate the skin sensitization and irritation potential of BDPE. RESULTS: BDDE levels were non-detectable in all analyzed products. By contrast, free BDPE content varied markedly, with over 1000-fold differences observed between products, indicating substantial variability in purification efficiency across manufacturing processes. Considerable variability was also identified among Food and Drug Administration-approved products, with some containing BDPE concentrations exceeding 100 ppm. Conversely, several products exhibited low BDPE levels ranging from 0.1 to 2.5 ppm, further highlighting inconsistencies in manufacturing control. CONCLUSIONS: Industry claims regarding complete cross-linker removal may fail to account for the persistence of BDPE species. The substantial inter-product variability observed in this study suggests inadequate process control among manufacturers. Given the structural similarity of BDPE to known sensitizers and the direct dermal injection route that circumvents the skin barrier, free BDPE should be designated a critical quality attribute with defined acceptance limits. These findings suggest that BDPE can be reduced to concentrations below 2.5 ppm, supporting the need for stricter manufacturing standards.
An Open-Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10-Peptide Face and Neck Serum to Address Skin Quality.
Cayce K, Jacobs KM, Boda S
J Cosmet Dermatol · 2026 Mar · PMID 41797621 · Full text
BACKGROUND: There is increasing patient demand for improved skin quality and the desire to achieve rejuvenated skin and improve self-confidence. AIMS: The objective of this 12-week study was to assess changes in skin qua...
BACKGROUND: There is increasing patient demand for improved skin quality and the desire to achieve rejuvenated skin and improve self-confidence. AIMS: The objective of this 12-week study was to assess changes in skin quality and subject satisfaction after using a novel anti-aging 10-peptide serum (Pep Up Collagen Boost Face & Neck Serum; Colorescience Inc., Carlsbad, CA). PATIENTS/METHODS: Healthy adult subjects seeking facial and neck skin rejuvenation (N = 48) were divided into two groups. Group A included subjects not currently using prescription, medical grade, advanced, or physician-dispensed skincare products and Group B included subjects who currently were using such products. Subjects in both groups applied the anti-aging peptide serum twice daily as part of their daily skincare routine for 12 weeks and were evaluated after 4, 8, and 12 weeks of treatment. Improvements in Global Skin condition and other parameters associated with skin quality were assessed by three investigators. RESULTS: By Week 12, 89.6% of subjects showed clinical improvement (p < 0.01), with most (52%) achieving moderate-to-marked global improvement. Both groups had median global scores of 3.0, with similar mean scores (Group A, 2.6; Group B, 2.8). Subjects in both groups indicated improvements in global scores (Group A, 91.7%; Group B, 87.5%) and most subjects in both groups demonstrated marked improvements from baseline (54.2% and 50.0%). The product was well-tolerated and subject satisfaction was high. CONCLUSIONS: The twice-daily application of a novel anti-aging 10-peptide serum restores several markers of facial and neck skin quality that were incremental to basic skincare routines and professional skincare regimens.
Correction to "Managing Aesthetic Needs in Prescription Medication-Driven Rapid Weight Loss Patients: Results of an International Consensus. The Clinician Perspective".
J Cosmet Dermatol · 2026 Mar · PMID 41796982 · Full text
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Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta-Analysis.
Peng Y, Sun M, Chen J … +2 more , Huang X, Zhang F
J Cosmet Dermatol · 2026 Mar · PMID 41796703 · Full text
BACKGROUND: Rosacea is a chronic inflammatory dermatosis. While standard therapies exist, managing refractory subtypes remains a therapeutic challenge. Oral Janus kinase (JAK) inhibitors have emerged as potential alterna...
BACKGROUND: Rosacea is a chronic inflammatory dermatosis. While standard therapies exist, managing refractory subtypes remains a therapeutic challenge. Oral Janus kinase (JAK) inhibitors have emerged as potential alternatives, but systematic evidence is lacking. AIMS: To evaluate the efficacy and safety of oral JAK inhibitors for rosacea through a systematic review and meta-analysis. METHODS: A comprehensive search was conducted in five databases from inception to December 1, 2025. The primary outcome was the pooled clinical response rate. Secondary outcomes included the Investigator's Global Assessment (IGA), Clinician's Erythema Assessment (CEA), and Dermatology Life Quality Index (DLQI). RESULTS: Eleven studies involving 57 patients were included. The overall pooled response rate was 89.9% (95% CI: 74.4%-99.4%), with low heterogeneity (I = 16.3%). Regarding secondary outcomes, 67.8% of patients achieved an IGA score of ≤ 1, and 74.6% achieved a CEA reduction of ≥ 2 points. DLQI score also decreased from 17.30 ± 3.80 to 10.00 ± 3.43. Adverse events were reported in 10.5% of patients. CONCLUSIONS: Oral JAK inhibitors show promising potential as a therapeutic option for refractory rosacea. However, given the small sample size and single-arm design, these findings are exploratory. Large-scale randomized controlled trials are urgently needed to validate these findings and guide stratified treatment.
See, Touch, Feel, and Express: Achieving Safe and Natural Outcomes With HA Fillers-An International Consensus.
Suwanchinda A, Choi H, Corduff N … +11 more , Cui H, Garcia LGT, Kerscher M, Lim TS, Ong O, Park JY, Praditsuwan D, Siew TW, Tseng FW, Wu R, Pavicic T
J Cosmet Dermatol · 2026 Mar · PMID 41794404 · Full text
BACKGROUND: The concept of "natural outcomes" in filler treatments has been explored in clinical studies and literature, yet remains loosely defined, subjective, and lacks standardized assessment criteria. AIMS: To propo...
BACKGROUND: The concept of "natural outcomes" in filler treatments has been explored in clinical studies and literature, yet remains loosely defined, subjective, and lacks standardized assessment criteria. AIMS: To propose a multidimensional Natural Outcomes Framework to systematically define, assess, and communicate natural outcomes following hyaluronic acid (HA) filler treatment, facilitating attainment of desired results. METHODS: An international aesthetic multidisciplinary panel developed consensus statements and a practical framework for achieving safe and natural outcomes with HA fillers based on insights from a literature review, survey, and expert meeting. RESULTS: This expert consensus emphasizes safety as a foundational aspect of natural outcomes. The framework extends beyond visual outcomes ("See") to encompass tactile ("Touch"), experiential ("Feel") and expressive ("Express") dimensions of naturalness, which can be assessed by various methods. The panel identified three categories of factors affecting natural outcomes: product, patient, and injector factors. Treatment can be optimized by selecting HA fillers with biomimetic design, suitable rheological properties, and low inflammatory potential; ensuring knowledge and technical competency; individualizing treatment plans; and fostering effective communication. A practical clinical workflow was devised to guide the attainment and assessment of safe and natural outcomes from pre-treatment to follow-up. CONCLUSIONS: The Natural Outcomes Framework offers a structured approach to achieving safe and desired outcomes with HA fillers, aligned with this principle: "treat the patient, not the photograph." It promotes patient-practitioner alignment on treatment goals and use of appropriate products based on biomimetic design principles, contributing to the attainment of predictable and satisfying results with aesthetic HA filler treatments.
Re: "Three Calcium Hydroxylapatite-Based Dermal Fillers Marketed in Mexico: Comparison of Particle Size and Shape Using Electron Microscopy" by Sanchez Rico and Andrade Canto, Journal of Cosmetic Dermatology 2025; 24(3): e70100.
Furman-Assaf S, Korman S
J Cosmet Dermatol · 2026 Mar · PMID 41793193 · Full text
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Enhancement of the Moisturizing Effect in an Injectable Sodium Hyaluronate Composite Solution by the Addition of Glycine, Alanine, and Proline.
Shi A, Guan Y, Chen S … +5 more , Ding Y, Chen Y, Zeng S, Hu Y, Dong H
J Cosmet Dermatol · 2026 Mar · PMID 41792933 · Full text
BACKGROUND: Hyaluronate (HA) is widely utilized in skin rejuvenation treatments, yet mono-component injectable sodium hyaluronate solution (ISHA) is limited by its modest moisturizing performance and frequent dosing requ...
BACKGROUND: Hyaluronate (HA) is widely utilized in skin rejuvenation treatments, yet mono-component injectable sodium hyaluronate solution (ISHA) is limited by its modest moisturizing performance and frequent dosing requirements. The combination of HA with active ingredients such as amino acids represent a promising strategy to improve hydration efficacy. AIMS: This study aimed to develop a novel injectable sodium hyaluronate composite solution (Co-ISHA) incorporating three amino acids-glycine, alanine, and proline-and to systematically evaluate its moisturizing effects through phenomenological and mechanistic analyses at cellular and tissue levels. METHODS: This study developed a novel Co-ISHA containing glycine, alanine, and proline, and evaluated its moisturizing performance through a comprehensive in vitro assessment system. The reparative and protective effects of Co-HA on cells and tissues under dry conditions were examined, along with the expression of moisturizing-related genes and natural moisturizing factors (NMF). This system integrated both cellular and tissue-level models to elucidate the underlying mechanisms. RESULTS: The results indicated that the addition of these three amino acids significantly enhanced the moisturizing efficacy of hyaluronic acid (HA). Both cellular and tissue-level evidence confirmed that, compared to single-component HA, Co-ISHA more effectively protected and repaired cells damaged by dryness and promoted the production of moisturizing-related genes and NMF. CONCLUSION: This study successfully developed a Co-ISHA formulation with superior moisturizing properties and established a robust in vitro evaluation system for assessing hydration efficacy. The findings provide a strategic framework for advancing the development of "Cruelty-Free" cosmetic products.
Lifting Efficiency of Barbed Sutures for Potential Face Lifting Application: A Parametric Analysis.
Su CY, Prajapati MJ, Lin JR … +2 more , Jiang CP, Fang HW
J Cosmet Dermatol · 2026 Mar · PMID 41792036 · Full text
BACKGROUND: Absorbable barbed sutures have been widely used for minimally invasive facial rejuvenation. However, clinical lifting performance varies due to differences in suture geometry, which remain insufficiently quan...
BACKGROUND: Absorbable barbed sutures have been widely used for minimally invasive facial rejuvenation. However, clinical lifting performance varies due to differences in suture geometry, which remain insufficiently quantified. OBJECTIVE: The study aims to evaluate the effects of barb rotation angle, barb orientation, and pulling speed on the lifting performance and efficiency of the barbed sutures. The goal is to identify the optimized geometric design for facial lifting applications. METHODS: The barbs were fabricated with four rotation angles (30°, 45°, 90°, and 180°) and four orientations (Forward, Reverse, Forward-Reverse, and Reverse-Forward). The fabricated sutures were tested at 10, 50, and 100 mm/min. Maximum lifting and holding displacements and lifting efficiency were quantified. Statistical analysis was conducted using one-way ANOVA with Tukey's post hoc test (p < 0.05). RESULTS: Higher pulling speed increased maximum lift but reduced efficiency due to slippage. The maximum lift was at 100 mm/min (2.03 ± 0.08 mm), whereas the highest lifting efficiency was at 10 mm/min (42.7%). For the barb rotation angles, the 90° configuration showed the highest lifting efficiency (35.5%) and superior anchor stability (p < 0.05). Regarding the barb orientation, the Forward orientation produced the largest lift (1.72 ± 0.18 mm), while the Forward-Reverse orientation achieved the highest efficiency (35.5%). The optimized Forward-Reverse 90° configuration exhibited improved holding capacity and reduced slippage compared to a commercial barbed suture. CONCLUSION: Barb geometry critically affects the lifting performance of the suture. The Forward-Reverse 90° configuration shows the optimal lifting efficiency and stability, offering clinically relevant guidance for designing next-generation facial lifting sutures.
Reprogramming Skin Aging: A Regenerative and Epigenetic Perspective on Cutaneous Longevity.
Haykal D, Gold M, Lain E … +2 more , Green J, Farris PK
J Cosmet Dermatol · 2026 Mar · PMID 41792029 · Full text
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Enhanced Anti-Aging Properties of Silymarin With a Natural Phytochemical Ratio Over Commercial Formulations.
Hou S, Wang A, Song H … +1 more , Li A
J Cosmet Dermatol · 2026 Mar · PMID 41787247 · Full text
BACKGROUND: Silymarin, a bioactive mixture widely used in anti-aging cosmetic products, is primarily composed of silybin, silychristin, and silydianin. The relative proportions of these three compounds in milk thistle se...
BACKGROUND: Silymarin, a bioactive mixture widely used in anti-aging cosmetic products, is primarily composed of silybin, silychristin, and silydianin. The relative proportions of these three compounds in milk thistle seeds, the natural source of silymarin, differ significantly from those found in commercially available silymarin formulations. Notably, under natural conditions, silymarin contains a higher proportion of silybin than its commercial formulations. OBJECTIVES: This study aimed to comparatively evaluate how differences in these ratios affect the anti-aging properties of silymarin and to unveil the underlying mechanism. METHODS: We quantified the natural and commercial ratio of silymarin. We measured the cytotoxicity of the natural and commercial silymarin mixtures, as well as individual silybin, silychristin, and silydianin. We studied the matrix metalloproteinases (MMPs) inhibition capacities of natural and commercial silymarin mixtures as a sign of their anti-aging properties. The mechanism of enhanced anti-aging properties was studied by ROS scavenging assay, reducing power assay, pro-inflammatory factor inhibition assay, using natural and commercial silymarins, as well as individual silybin, silychristin, and silydianin. Finally, an anti-wrinkle experiment on human faces was conducted using an emulsion containing natural silymarin. RESULTS: We demonstrated that silymarin composed of the natural phytochemical ratio exhibits superior anti-aging efficacy compared to silymarin prepared using the "commercial ratio." This finding was evidenced by its greater inhibitory effect on MMPs in human dermal fibroblasts, which are involved in collagen degradation in the dermis. Thus, the natural silymarin mixture was more effective at preventing collagen degradation. Reactive oxygen species (ROS) production, the primary trigger for MMP synthesis, was attenuated more strongly by the natural silymarin mixture, likely due to the higher ROS scavenging capacity of silybin compared to silychristin and silydianin. Notably, although the reducing ability of individual compounds (silybin, silychristin, and silydianin), as well as both natural and commercial silymarin mixtures, was studied, no correlation between reducing power and ROS scavenging capacity was observed. The natural silymarin mixture was also more effective at downregulating tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine, though it did not affect interleukin-6 expression. This effect was also attributed to the higher anti-TNF-α capacity of silybin compared to that of silychristin and silydianin. Finally, an emulsion containing the natural ratio of silymarin was found to be effective in reducing facial wrinkles. CONCLUSION: To our knowledge, this study is the first to unveil the mechanistic basis underlying the superior anti-aging properties of silymarin containing a natural phytochemical ratio over commercial silymarin formulations. These findings are anticipated to be useful in producing better silymarin-based anti-aging cosmetic products.
Human Derived Exosome Injections (ASCE+ vs. CELLEXOSOME) Enhance Collagen Remodeling and Angiogenesis in Intact Skin: A Comparative Experimental Study.
Adel N, Kolenda J, Llano F … +8 more , Thulesen J, Crespo FHG, Shen Y, Jo YK, Resendiz GYZ, Torres DIB, Lopez-Lara JA, Thulesen IV
J Cosmet Dermatol · 2026 Mar · PMID 41787206 · Full text
BACKGROUND: Exosomes derived from human cells have emerged as promising biological agents for enhancing skin quality through stimulation of collagen remodeling and angiogenesis. While their role in wound healing is well...
BACKGROUND: Exosomes derived from human cells have emerged as promising biological agents for enhancing skin quality through stimulation of collagen remodeling and angiogenesis. While their role in wound healing is well established, their effects on intact, non-injured skin remain insufficiently investigated. Their biological activity depends on their molecular cargo, including growth factors, extracellular matrix-modulating proteins, and angiogenic microRNAs. OBJECTIVE: To evaluate the impact of intradermal injection of two human-derived exosome formulations on dermal architecture and vascular density in intact skin. METHODS: A total of 96 adult male Syrian golden hamsters were randomly assigned to four equal groups: untreated control, saline injection, Cell Exosome (0.1 mL), or ASCE+ Exosome (0.1 mL). Skin biopsies were collected at baseline, day 3, day 7, and day 14 post injection, with equal numbers of animals sacrificed per group and time point. Histological analyses (Hematoxylin & Eosin, Masson's Trichrome, Van Gieson) assessed dermal architecture and collagen organization, while CD34 immunohistochemistry quantified microvascular density. Quantitative image analysis was performed using ImageJ, with five high power fields evaluated per specimen. All assessments were performed in a blinded manner. RESULTS: Untreated control and saline groups showed no significant histological or immunohistochemical changes across all time points, consistent with normal tissue architecture. Cell Exosome treatment produced moderate increases in collagen deposition and CD34 positive vessels. Quantitatively, ASCE+ increased collagen density and microvascular counts compared with Cell Exosome (p < 0.05), whereas control and saline groups showed no measurable changes. CONCLUSIONS: Human derived exosomes promote collagen remodeling and angiogenesis in intact skin, with ASCE+ Exosome exhibiting superior efficacy over Cell Exosome. These findings highlight the potential of exosome-based therapies as minimally invasive strategies for skin rejuvenation.
Assessing the Benefits of an Innovative Chemical Peel Containing Biofunctionals on Adult Acne-Prone Skin: An Exploratory Interventional Study: A Preliminary Report.
Brooks S, Rajagopal S, Handler MZ … +2 more , Vandeven M, Carlile A
J Cosmet Dermatol · 2026 Mar · PMID 41784356 · Full text
BACKGROUND: Acne is the most prevalent skin disorder in the United States, affecting up to 50 million people from all age groups. Treatment options include topical and systemic therapies. Limitation in many treatment opt...
BACKGROUND: Acne is the most prevalent skin disorder in the United States, affecting up to 50 million people from all age groups. Treatment options include topical and systemic therapies. Limitation in many treatment options opens avenues for alternative therapies, such as chemical peeling. AIMS: This exploratory study, funded by Colgate Palmolive company, aimed to evaluate the effectiveness of a new chemical peel (PCAskin Acne Peel Plus) in treating adult acne. The novel peel features a blend of acids and biofunctional ingredients designed to aid in acne management. The study's primary objective was to assess the novel peel's effectiveness in positively influencing acne severity, specifically by reducing acne lesions, papules, and pustules. PATIENTS: Sixteen participants aged 25-40 years old, with Fitzpatrick skin types I-VI, presenting evidence of mild-to-moderate acne, were assessed over a 12-week period following treatment initiation. EVALUATION METHODS: The effects of the test peel on acne were evaluated using a combination of methods. Skin sebum was measured using a moisture meter (BGJOY, SK-IV digital moisture monitor for skin). Photographic data was obtained using the Canfield Visia CR System (Canfield, Fairfield, NJ; model Generation 7, software version 8) for determining acne severity, appearance of skin pores, texture and redness. Acne severity was assessed by the study investigator using the Investigator Global Assessment (IGA) acne severity scale from the Visia images. Subjective assessment of skin parameters (acne severity, oiliness of the skin, pore size, skin discoloration, skin texture/smoothness, overall clarity of skin tone, and changes in scarring appearance) was also obtained at the start (Day 0) and end (Week 12) of the study using self-assessment questionnaires filled out by the study subjects. RESULTS: Significant decreases in total acne lesions (papules + pustules; p-value = 0.012) and papules (p-value = 0.023) were observed at the outset of the study (Week 12) compared to baseline (Day 0), with an average change (standard deviation) of -2.0 (2.6) and -1.8 (2.5) lesions, respectively. In addition, significant improvements in sebum content (Week 12, p-value = 0.042), erythema (Week 12, p-value = 0.030), and pore appearance (Day 1; p-value = 0.005; Week 12, p-value = 0.003) were observed compared to baseline. Positive perceptions of the treatment among participants and perceived improvements in acne severity (p-value = 0.004) and skin clarity (p-value = 0.036) were also highlighted. No adverse effects were observed during the study. CONCLUSIONS: This preliminary exploratory study indicates that treatment with a novel chemical peel appeared to yield a range of benefits for adults with acne-prone skin, supporting its potential as a safe, inexpensive, and minimally invasive treatment for the management of mild-to-moderate forms of adult acne. Further large scale, controlled studies are necessary to confirm these initial findings.
Non-Surgical Hip Augmentation With a PDLLA-Hyaluronic Acid.
Lee HE, Wan J, Yu KW … +6 more , Song JK, Rosellini I, Garson S, Cartier H, Ascher B, Yi KH
J Cosmet Dermatol · 2026 Mar · PMID 41777074 · Full text
BACKGROUND: Hip contouring is experiencing growing demand within aesthetic medicine, a trend particularly pronounced in Asian populations where cultural preferences emphasize harmoniously proportioned feminine silhouette...
BACKGROUND: Hip contouring is experiencing growing demand within aesthetic medicine, a trend particularly pronounced in Asian populations where cultural preferences emphasize harmoniously proportioned feminine silhouettes. While surgical augmentation remains an option, its inherent procedural risks and protracted recovery periods underscore the need for effective minimally invasive alternatives. Volumetric enhancement using biostimulatory agents, such as poly-D,L-lactic acid (PDLLA), constitutes a non-surgical approach. OBJECTIVE: This study aimed to evaluate the safety, efficacy, and patient satisfaction of bilateral hip augmentation using PDLLA in a cohort of Korean women. METHODS: A prospective case series was conducted involving 30 Korean women (age range: 24-48 years). Participants underwent bilateral hip augmentation between January and June 2024 using a PDLLA-HA hybrid biostimulator (Juvelook G[export name: Juvelook GLAM]). The mean total volume administered was 201.5 mL (range: 180-220 mL; approximately 100 mL per side, range: 90-110 mL). Outcomes were assessed using the Global Aesthetic Improvement Scale (GAIS), patient satisfaction scores (0-10 scale), and standardized photography at the 6-month follow-up. RESULTS: All 30 participants completed the study protocol. No significant adverse events were reported. Mean patient satisfaction at 6 months was 8.7/10 (±0.9 SD). Based on GAIS assessments, 27 participants (90%) demonstrated moderate to significant aesthetic improvement. Minor transient complications included swelling (n = 13, 43.3%) and mild discomfort (n = 8, 26.7%), all resolving spontaneously within 1 week. CONCLUSIONS: PDLLA hip augmentation, using total volumes approximating 200 mL, demonstrates a favorable safety profile and high efficacy in this cohort of Korean women. The results indicate this approach presents a viable minimally invasive alternative to conventional surgical implant procedures.
Correction to "A combination of a dermocosmetic and a sunscreen reduces acne severity and signs of post-inflammatory hyperpigmentation in subjects with Fitzpatrick phototypes ranging from I to VI".
J Cosmet Dermatol · 2026 Mar · PMID 41775459 · Full text
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Objective Assessment of the Onset of RelabotulinumtoxinA in the Elevation of the Eyebrow and Its Clinical Implications.
Di Gregorio C, Iozzo I, Belmontesi M … +5 more , De Santis A, Leone L, Innocenti A, Picaut P, Tretti-Clementoni M
J Cosmet Dermatol · 2026 Mar · PMID 41772706 · Full text
BACKGROUND: The new ready-to-use botulinum toxins effectively treat lateral canthal lines; there is still little data on their efficacy in treating glabellar lines. The combined treatment of lateral canthal and glabellar...
BACKGROUND: The new ready-to-use botulinum toxins effectively treat lateral canthal lines; there is still little data on their efficacy in treating glabellar lines. The combined treatment of lateral canthal and glabellar lines allows the eyebrow to be repositioned. AIMS: To show the onset and action of RelabotulinumtoxinA on the periocular area, by measuring the variations of the area under the eyebrow in a real-life setting. PATIENTS/METHODS: In this real-life, multi-center case series, 36 patients (30 women, 6 men), aged 30-62 years, were treated with RelabotulinumtoxinA in glabellar and lateral canthal areas; patients were treated on day 0 (T0) and followed until day 30. Photos taken at T0 and at all follow-up time points were compared in calculating the median of the palpebral surface. RESULTS: All patients responded to the treatment. Most of RelabotulinumtoxinA's effect on eyebrow position (76.25%) was seen within day 2, peaking in the first 24 h. The variation rate sharply declines by day 7. Patients showed a median increase in the exposed eyelid area of +11.91% compared to T0. CONCLUSIONS: In the real-world setting, RelabotulinumtoxinA showed efficacy in treating GLs and LCLs. In the post-intervention phases (follow-up and potential touch-ups), the fast onset of the ready-to-use product can save time. The palpebral area measurement technique, which was selected to assess objectively the response, may allow for a higher level of precision than measuring distances in the periocular range and can be helpful in this type of study.
Rapid, Strong, and Visible Efficacy of a Dermocosmetic in Acne Patients With Dark Skin Phototypes: Results of a Randomized Split-Face Study.
Queille-Roussel C, Odeimi J, Broallier M … +2 more , Kerob D, Tan J
J Cosmet Dermatol · 2026 Mar · PMID 41772684 · Full text
INTRODUCTION AND OBJECTIVES: Acne is a chronic inflammatory skin disease that can cause acne-induced hyperpigmentation (AIH), especially in subjects with phototype IV and above (hereafter darker skin tones). This study e...
INTRODUCTION AND OBJECTIVES: Acne is a chronic inflammatory skin disease that can cause acne-induced hyperpigmentation (AIH), especially in subjects with phototype IV and above (hereafter darker skin tones). This study evaluated the efficcay kinetics of a dermocosmetic cream (DC cream) in adults with darker skin phototypes and mild to moderate acne. MATERIAL AND METHODS: An intra-individual, randomized, split face, single centre 57 day-study was conducted in 16 adults with dark skin tones (phototype IV, V and VI) and mild-to-moderate acne. DC cream was applied 2/day on one hemiface. Assessments included total, inflammatory and non-inflammatory lesion counts, AIH intensity and darkness severity, PAHPI score and local tolerance. Subjects rated the perceived benefits of DC cream. RESULTS: 75% of subjects were women, mean age was 26.8 ± 6.7 years; 50% had phototype IV, 31.2% phototype V, and 18.8% phototype VI. 68.8% had mild (GEA 2) and 31.2% moderate (GEA 3) acne. The total lesion count significantly decreased from Day 5 (-17.1%; p < 0.05) until Day 57 (-44.9%; p < 0.01) on the DC-treated side versus - 28.4% on the untreated side at Day 57. Inflammatory and non-inflammatory lesion counts significantly (p < 0.01) decreased from Day 11 to Day 57 with DC cream. AIH marks intensity significantly (p < 0.01) decreased starting Day 11 until Day 57; as did the PAHPI score (-22.7%) after 57 days with hemi-face differences being significantly (p < 0.05) in favor of DC cream. AIH darkness severity significantly improved with DC cream, with no changes on the untreated side. DC cream was highly appreciated and very well tolerated by the subjects. CONCLUSIONS: This clinical study provides strong evidence on the efficacy kinetics of a DC cream in acne management in subjects with dark skin tones. It shows that early, daily and specific treatment with a targeted DC significantly improves all acne lesions type, as well as AIH marks as soon as 11 days of use, in addition to exhibiting high patient satisfaction rates and excellent tolerability.
Integrating Dermocosmetics Into Acne Care in Latin America.
Troielli P, Moreno J, Cortes A … +4 more , Cardenas P, Kerob D, Gamarra A, Dreno B
J Cosmet Dermatol · 2026 Mar · PMID 41766326 · Full text
BACKGROUND: Prescription acne products have proven efficacy and safety, yet management can pose a challenge. This review discusses the benefits of adding dermocosmetics to acne management. METHODS: We add expert consensu...
BACKGROUND: Prescription acne products have proven efficacy and safety, yet management can pose a challenge. This review discusses the benefits of adding dermocosmetics to acne management. METHODS: We add expert consensus with review of the literature to provide guidance for clinicians managing patients with acne in Latin America. RESULTS: There is increasing evidence that dermocosmetics (over-the-counter cleansers, moisturizers, and sunscreens that contain acne-targeting ingredients) can be a good alternative to prescription acne treatments as well as adjuncts. Milder forms of acne may be present in any age patient, but prepubertal acne and acne cosmetica may be particularly well suited to a dermocosmetic approach. More severe acne may need a dermocosmetic added if there is sensitive skin or poor tolerance to prescription medications, and when the patient or family does not wish to use antibiotics or other acne prescription treatments. Dermocosmetics may be used as adjuncts to any type of prescription therapy, but may be most effective when used with products associated with skin irritation such as topical retinoids or benzoyl peroxide. Appropriate dermocosmetics can also fortify the skin barrier and help to protect the skin microbiome. CONCLUSIONS: Acne management is complex and there can be adherence, tolerability, and efficacy problems. Dermocosmetics alone can be used in milder forms of acne or in maintenance post treatment, as a good compromise between efficacy and tolerability. As adjuncts, dermocosmetics can also decrease skin irritation and thereby increase adherence, can enhance the efficacy of prescription therapies, and can normalize dysbiosis in acne.
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