Journal Of Cosmetic Dermatology[JOURNAL]
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200 papers
Research Progress on Platelet-Rich Plasma (PRP) in the Treatment of Androgenetic Alopecia.
Zhong Z, Luo L, Zhao L … +2 more , Yue X, Lu Y
J Cosmet Dermatol · 2026 Apr · PMID 41877369 · Full text
BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of progressive hair loss, significantly affecting quality of life. Current therapies, such as minoxidil, finasteride, and hair transplantation, show variab...
BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of progressive hair loss, significantly affecting quality of life. Current therapies, such as minoxidil, finasteride, and hair transplantation, show variable efficacy and may be associated with adverse effects. Platelet-rich plasma (PRP), an autologous preparation enriched with platelets and growth factors, has recently gained attention as a regenerative option for hair restoration. OBJECTIVE: This review summarizes advances in PRP therapy for AGA, focusing on preparation techniques, mechanisms of action, clinical efficacy, and safety, and provides recommendations for protocol optimization and future research. METHODS: A systematic search of PubMed, Web of Science, Embase, Cochrane Library, and CNKI was conducted for studies published between 2000 and 2025. Eligible articles included randomized controlled trials, cohort studies, case-control studies, and meta-analyses evaluating PRP preparation methods or therapeutic outcomes. Study quality was appraised using the Cochrane Risk of Bias, ROBINS-I, and GRADE frameworks. RESULTS: PRP promotes follicular regeneration through angiogenesis and activation of Wnt/β-catenin, MAPK, Akt/ERK, and Notch signaling pathways. Clinical trials demonstrate improved hair density, thickness, and patient satisfaction, particularly when PRP is combined with minoxidil, microneedling, or laser therapy. Reported adverse events are mild and transient, such as localized pain or erythema. Nevertheless, heterogeneity in centrifugation, activation, and delivery protocols contributes to inconsistent outcomes across studies. CONCLUSION: PRP represents a promising, safe, and minimally invasive therapy for AGA. Establishing standardized preparation protocols and conducting large-scale randomized studies are essential to confirm long-term efficacy and integrate PRP into routine, personalized AGA management.
Ultra-Low-Dose Isotretinoin for Acne: A Pilot Evaluation of Efficacy and Tolerability in Chinese Patients.
Shi S, Liu J, Pan L … +1 more , Hua W
J Cosmet Dermatol · 2026 Apr · PMID 41876213 · Full text
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Cross-Cultural Beliefs and Stigmatization in Vitiligo: A Systematic Review.
Ma S, Zieneldien T, Tan IJ … +1 more , Jafferany M
J Cosmet Dermatol · 2026 Apr · PMID 41873648 · Full text
BACKGROUND: Vitiligo is an autoimmune condition marked by depigmentation of the skin and is frequently associated with psychosocial distress. Although often dismissed as cosmetic, vitiligo carries a substantial burden in...
BACKGROUND: Vitiligo is an autoimmune condition marked by depigmentation of the skin and is frequently associated with psychosocial distress. Although often dismissed as cosmetic, vitiligo carries a substantial burden influenced by cultural beliefs, stigma, and access to medical education. AIMS: This review aims to examine the literature on cross-cultural beliefs, stigmatization, psychological comorbidities, and quality of life (QoL) outcomes in individuals with vitiligo. METHODS: A comprehensive search of PubMed, Embase, and PsycINFO was conducted to identify peer-reviewed studies discussing cultural beliefs, stigma, psychological burden, or QoL in individuals with vitiligo. Inclusion criteria encompassed original studies in English assessing relevant psychosocial or cultural domains. RESULTS: Twenty-three studies met inclusion criteria. Cultural attributions of vitiligo varied widely, with some populations linking the disease to contagion, divine punishment, or supernatural causes. These beliefs were more prevalent in regions with lower health literacy and limited access to dermatologic care. Stigmatization-manifesting as social exclusion, employment and marital discrimination, and internalized shame-was consistently reported across settings, though more severe in female patients and individuals with darker skin phototypes in certain regions. QoL impairment was greater in African, Middle Eastern, and South Asian populations compared to Western cohorts. Coping strategies included concealment, spiritual reliance, and use of complementary and alternative medicine (CAM). CONCLUSION: Vitiligo imposes a global psychosocial burden that is amplified by cultural misconceptions and stigma. Culturally tailored, multidisciplinary interventions-including education, psychological support, and community-based stigma reduction-are crucial to improving outcomes. Future research should focus on high-stigma, underrepresented populations to inform equitable care.
A Case Series on a Layered Biomaterial Strategy for Midface Rejuvenation: Combining Collagen Stimulators and Hyaluronic Acid.
Ao YJ, Zhou YJ
J Cosmet Dermatol · 2026 Apr · PMID 41873133 · Full text
BACKGROUND: The midface is a key area where aging signs first appear, involving multi-layered changes such as epidermal fine lines, volume loss leading to hollowing and sagging, and deep structural support weakening resu...
BACKGROUND: The midface is a key area where aging signs first appear, involving multi-layered changes such as epidermal fine lines, volume loss leading to hollowing and sagging, and deep structural support weakening resulting in nasolabial fold deepening. Single-material treatments often fail to address this complexity comprehensively. While hyaluronic acid (HA) effectively restores volume, its impact on skin texture is limited; collagen stimulators promote long-term collagen regeneration but lack immediate shaping capability. OBJECTIVE: Through the presentation of six typical cases, this study aims to illustrate the clinical application of a layered treatment strategy using HA and collagen stimulators, either alone or in combination. It seeks to describe how this anatomy-based approach can address single or compound midface aging signs and provide a preliminary clinical reference for comprehensive rejuvenation. METHODS: This descriptive case series included six female patients with distinct midface aging phenotypes. Efficacy was assessed blindly by independent physicians using standardized scales (GAIS, Merz, Hirmand, MVDSS, WSRS). RESULTS: All cases showed improvement in target aging signs. Quantitative improvements were observed: Case 3 (infraorbital hollowing) improved from Merz Grade 2 to 1; Case 4 from Merz Grade 4 to 1; Case 5 (tear trough) improved from Hirmand Grade 2 to 0 at 6 months; and Case 6 (compound aging) showed progressive improvement, with Hirmand, MVDSS, and WSRS scores all improving by at least two grades at the 10-month follow-up. Treatments were well-tolerated, with only transient, expected reactions observed. CONCLUSION: This case series suggests that a combined/layered treatment strategy based on anatomical presentation may offer a safe and effective option for personalized midface rejuvenation. These preliminary observations provide a basis for future research and should be interpreted within the limitations of a small, non-comparative study design.
Comment on "Post-Botulinum Headache in Cosmetic Practice: A Prospective Study".
Singh N, Srivastav M
J Cosmet Dermatol · 2026 Apr · PMID 41873116 · Full text
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Dual-Targeting Oligopeptide-215 Regulates Skin Barrier Homeostasis Through Concurrent Modulation of JAK-STAT and NF-κB Signaling.
Zhang Q, Hu C, Chen Y … +4 more , Chen Y, Guo C, Liu Z, Ding W
J Cosmet Dermatol · 2026 Mar · PMID 41858149 · Full text
OBJECTIVE: To evaluate Oligopeptide-215, a biomimetic peptide engineered from amphibian skin secretions, for its dual capacity to restore skin barrier homeostasis by concurrently targeting physical barrier proteins and i...
OBJECTIVE: To evaluate Oligopeptide-215, a biomimetic peptide engineered from amphibian skin secretions, for its dual capacity to restore skin barrier homeostasis by concurrently targeting physical barrier proteins and inflammatory pathways via JAK-STAT and NF-κB modulation. METHODS: In vitro models used UVB-damaged HaCaT keratinocytes, LPS-stimulated RAW264.7 macrophages, and IL-4/IL-13-stimulated HaCaT cells. Assays included cell viability (MTT), migration (scratch), adhesion, barrier proteins (FLG/LOR; ELISA/IF), signaling phosphoproteins (pJAK1/pTYK2/pSTAT3/pSTAT6/pNF-κB; IF), and inflammatory mediators (NO/PGE₂/TNF-α/IL-6/IL-1β; ELISA). RESULTS: Oligopeptide-215 antagonizes IL-13/IL-4-mediated JAK-STAT6/STAT3 signaling, thereby restoring expression of critical barrier proteins FLG and LOR. Additionally, it suppresses inflammatory responses by inhibiting NF-κB-dependent cytokine production. In UVB-damaged keratinocytes, Oligopeptide-215 promotes cellular repair through enhanced proliferation, adhesion, and migration. CONCLUSION: These findings revealed an innovative repairing mechanism combining physical barrier with immunologic barrier, and established Oligopeptide-215 as a potential skincare ingredient for skin barrier dysfunction.
A Comprehensive Analysis of the Blurring Boundary Between Cosmetic Applications and Medical Treatment.
Kumbasar-Atay E, Keskinbora KH
J Cosmet Dermatol · 2026 Mar · PMID 41858135 · Full text
BACKGROUND: Dermatology and cosmetology have traditionally been regarded as distinct disciplines, with dermatology focused on the diagnosis and treatment of disease and cosmetology aimed at enhancing aesthetic appearance...
BACKGROUND: Dermatology and cosmetology have traditionally been regarded as distinct disciplines, with dermatology focused on the diagnosis and treatment of disease and cosmetology aimed at enhancing aesthetic appearance. In recent years, this distinction has become increasingly blurred due to technological advancements, expanding clinical applications, regulatory gaps, and sociocultural influences. AIMS: This review aims to examine the factors contributing to the blurring boundary between cosmetic and medical dermatologic practices and to evaluate its regulatory, ethical, and patient safety implications. METHODS: A narrative review of peer-reviewed literature, international regulatory frameworks, and professional guidelines was conducted. Dual-use dermatologic interventions, including botulinum toxin, dermal fillers, and laser- and energy-based devices, were analyzed across cosmetic and medical indications. Legal approaches in different jurisdictions and sociocultural drivers, such as social media-influenced aesthetic expectations, were also assessed. RESULTS: The review demonstrates that many dermatologic procedures are positioned simultaneously as cosmetic and medical interventions, creating ambiguity in regulation and professional accountability. The absence of a universally accepted legal definition for "cosmeceuticals," along with the expanding off-label use of aesthetic technologies, contributes to inconsistent oversight and potential risks to patient safety. Increased patient demand driven by idealized aesthetic standards further complicates expectation management and clinical decision-making. CONCLUSIONS: The convergence of cosmetic and medical dermatology highlights the need for clearer legal definitions, strengthened regulatory frameworks, and well-defined professional standards. A patient safety-centered approach, supported by improved public awareness and professional accountability, is essential to addressing the challenges associated with this blurred boundary.
Inhibitory Effects of Grape Stem Extracts From Douro Varieties on Skin-Aging Enzymes: A Sustainable Source of Cosmeceutical Agents.
Garcia-Marti M, Boutaub O, Nascimento APS … +2 more , Simal-Gandara J, Barros AN
J Cosmet Dermatol · 2026 Mar · PMID 41858130 · Full text
BACKGROUND: Grape stems are a major by-product of the winemaking process and remain largely underexploited despite their richness in bioactive phenolic compounds, representing an opportunity for sustainable valorization...
BACKGROUND: Grape stems are a major by-product of the winemaking process and remain largely underexploited despite their richness in bioactive phenolic compounds, representing an opportunity for sustainable valorization within a circular economy framework. AIMS: This study aimed to characterize the phenolic composition and evaluate the antioxidant and enzyme inhibitory activities of grape stem extracts from different cultivars grown in the Douro Demarcated Region. METHODS: Grape stems from 12 Vitis vinifera cultivars were extracted and analyzed for total phenolic content, ortho-diphenols, and flavonoids. Antioxidant capacity was assessed using FRAP and DPPH assays, while bioactivity was further evaluated through elastase and hyaluronidase inhibition assays. RESULTS: Total phenolic content ranged from 35.2 to 89.6 mg GAE/g DW, with Sousão exhibiting the highest values. Ortho-diphenols and flavonoids showed marked cultivar-dependent variability, with Verdelho and Cercial presenting values above 20 mg CAE/g DW and 15 mg QE/g DW, respectively. Antioxidant activity reached up to 920 μmol TE/g DW (FRAP) and 85% DPPH radical scavenging. Enzyme inhibition assays revealed strong cultivar-dependent bioactivity, with Sousão, Verdelho, and Gouveio extracts achieving over 60% inhibition of elastase and hyaluronidase. CONCLUSIONS: The results highlight the significant influence of grape cultivar on the bioactive potential of grape stems and support their valorization as promising raw materials for nutraceutical and cosmeceutical applications.
Application of Brachytherapy in Postoperative Treatment of Keloid-Prone Patients.
Tian H, Dai T, Yu C
J Cosmet Dermatol · 2026 Mar · PMID 41858122 · Full text
BACKGROUND: Keloids are benign fibroproliferative tumors that often recur after surgical excision. Combining surgery with postoperative radiotherapy has emerged as a potential treatment strategy, though optimal radiother...
BACKGROUND: Keloids are benign fibroproliferative tumors that often recur after surgical excision. Combining surgery with postoperative radiotherapy has emerged as a potential treatment strategy, though optimal radiotherapy protocols remain debated. OBJECTIVE: This study aims to preliminarily evaluate the efficacy and safety of a single high-dose brachytherapy session administered within 8 h after surgical excision in keloid-prone patients in a retrospective setting. METHODS: A retrospective case series analysis was conducted on 32 patients who underwent surgical excision of keloids followed by a single 8 Gy Ir-192 brachytherapy session within 8 h postoperatively. Treatment outcomes and adverse reactions were assessed over a 1-year follow-up period. RESULTS: Among the 32 patients, 25 were cured, 5 showed significant improvement, and 2 were ineffective, yielding a total effective rate of 93.75%. No severe radiation-induced skin reactions (Grade III/IV) or abnormalities in thyroid or estrogen levels were observed. CONCLUSION: In this small retrospective series, single-dose 8 Gy brachytherapy administered within 8 h after surgical excision was associated with a high response rate and no severe adverse events. These findings suggest it may be a potentially useful outpatient treatment option for keloids, though further comparative studies are needed to confirm its efficacy and safety.
Clinical Efficacy of Tofacitinib in Treating Granulomatous Reaction After Mesotherapy: A Case Series Analysis.
Shu C, Zhang T, Liu JW … +5 more , Zhu CY, Fang RY, Sun QN, Li N, Li F
J Cosmet Dermatol · 2026 Mar · PMID 41856785 · Full text
BACKGROUND: Mesotherapy, a widely utilized minimally invasive cosmetic procedure, carries potential risks of adverse reactions due to non-standardized protocols and overuse. Delayed granulomatous reactions represent a ch...
BACKGROUND: Mesotherapy, a widely utilized minimally invasive cosmetic procedure, carries potential risks of adverse reactions due to non-standardized protocols and overuse. Delayed granulomatous reactions represent a chronic complication, imposing significant physical and psychological burdens on patients. OBJECTIVE: This case series aims to evaluate the efficacy and safety of tofacitinib in managing non-infectious granulomatous reactions following mesotherapy. METHODS: This retrospective analysis included six patients diagnosed with non-infectious granulomatous reactions post-mesotherapy, treated at Peking Union Medical College Hospital between October 2021 and April 2025. All patients received oral tofacitinib. Clinical outcomes, treatment regimens, and safety profiles were assessed. RESULTS: All six patients demonstrated significant improvement in skin lesion severity, with no treatment-related adverse events observed during follow-up. CONCLUSION: Oral tofacitinib exhibits promising clinical efficacy and a favorable safety profile for non-infectious granulomatous reactions induced by mesotherapy, positioning it as a viable therapeutic option during the inflammatory phase.
Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti-Wrinkle Efficacy.
Radić B, Šuran J
J Cosmet Dermatol · 2026 Mar · PMID 41856779 · Full text
BACKGROUND: We recently demonstrated in a randomized controlled trial (RCT) that a Standardized Propolis Extract (SPE), produced via a patented non-alcoholic PEG 400/lecithin process, achieves significant clinical anti-w...
BACKGROUND: We recently demonstrated in a randomized controlled trial (RCT) that a Standardized Propolis Extract (SPE), produced via a patented non-alcoholic PEG 400/lecithin process, achieves significant clinical anti-wrinkle efficacy (34% wrinkle depth reduction). The present study investigates the underlying molecular mechanisms, specifically its potential senomorphic activity-the ability to modulate the Senescence-Associated Secretory Phenotype (SASP) without inducing cell death. OBJECTIVE: To evaluate the senomorphic activity of this chemically defined SPE (standardized to 1318.43 μg/g total phenolic markers) in an in vitro model of oxidative stress-induced senescence, providing molecular insights into its clinically observed anti-aging effects. METHODS: Human Dermal Fibroblasts (HDFs) were pre-treated with SPE (0.01%, 0.05%) or Rapamycin (3 μM, reference senomorphic control). Senescence was induced via a validated stress-induced premature senescence (SIPS) protocol (200 μM HO, 2 h). Gene expression for senescence markers (CDKN2A/p16, CDKN1A/p21), SASP cytokines (IL-6, IL-8), and cell cycle regulators (CDK4, CDK2, CCNE1) was quantified by qPCR. An exploratory study on Mesenchymal Stem Cells (MSCs) assessed SA-β-galactosidase activity qualitatively. RESULTS: The 0.05% SPE demonstrated potent senomorphic activity, significantly suppressing the key SASP marker IL-6 (FC: -7.78, p = 0.003)-comparable to the Rapamycin control (FC: -8.1, p = 0.003). Uniquely, SPE induced transcriptional upregulation of CDK4 (FC: +6.71, p = 0.002) and CDKN1A/p21 (FC: +2.33, p = 0.005), effects not observed with Rapamycin. In exploratory MSC experiments, SPE qualitatively reduced SA-β-gal staining. CONCLUSION: This first-in-class standardized propolis extract demonstrates distinct senomorphic activity, suppressing the inflammatory SASP (IL-6) while inducing transcriptional modulation of pro-regenerative pathways (CDK4). These molecular findings provide mechanistic insights consistent with the extract's clinically proven anti-wrinkle efficacy, supporting its positioning as an evidence-based active ingredient for dermo-cosmetic formulations targeting inflammaging.
Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Abedin ZU, Shah A, Mazhar S … +6 more , Khan SM, Aamir AB, Yousaf S, Fnu D, Mahato RK, Ansari A
J Cosmet Dermatol · 2026 Mar · PMID 41853869 · Full text
BACKGROUND: Acne vulgaris is one of the most prevalent disorders affecting 9%-10% of the global population, representing as papules, pustules, and comedones, with a pathogenesis involving increased sebum production, C. a...
BACKGROUND: Acne vulgaris is one of the most prevalent disorders affecting 9%-10% of the global population, representing as papules, pustules, and comedones, with a pathogenesis involving increased sebum production, C. acnes colonization, and inflammation. Conventional treatments like retinoids and antibiotics often cause side effects, thus diverting attention toward probiotics as an alternative therapy. Lactobacillus probiotics, having their immunomodulatory, anti-inflammatory, and antimicrobial properties, are useful in managing acne by reducing inflammation and oxidative stress with proved safety profile and the potential to reduce antibiotic reliance. This systematic review and meta-analysis evaluate the efficacy of Lactobacillus-based probiotics compared to placebo and benzoyl peroxide in reducing inflammatory lesions, non-inflammatory lesions, and total acne lesion counts. The findings aim to clarify their therapeutic role and provide evidence on their effectiveness and safety. OBJECTIVES: This systematic review and meta-analysis investigated the effectiveness of oral and topical Lactobacillus-based probiotics or postbiotics, compared with placebo or benzoyl peroxide, in patients with acne vulgaris. METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted, including studies evaluating oral or topical Lactobacillus-based probiotic or postbiotic interventions in patients with acne vulgaris. Primary outcomes were changes in inflammatory lesion counts, while secondary outcomes included non-inflammatory and total lesion counts, skin hydration, and sebum concentration. All analyses were performed using random-effects models with 95% confidence intervals (CI), and heterogeneity was quantified using the I statistic. RESULTS: A total of five RCTs involving 332 participants were included. The pooled mean difference for non-inflammatory lesions was -1.39 (95% CI -5.10 to 2.32, p = 0.46), for inflammatory lesions was -0.08 (95% CI -1.28 to 1.11, p = 0.89), and for total lesion counts was -9.07 (95% CI -20.71 to 2.57, p = 0.13). These results concluded that there was no significant reduction in lesion counts with Lactobacillus-based probiotics as compared to placebo or benzoyl peroxide. Heterogeneity was moderate to low across studies. CONCLUSION: This meta-analysis indicates that Lactobacillus-based probiotics do not provide significant clinical benefits in reducing inflammatory lesions, non-inflammatory lesions, and total acne lesion counts in Acne vulgaris patients compared to placebo or benzoyl peroxide.
Development and Validation of a Standardized Lip Fullness Grading Scale.
Choi SY, Jeong MK, Jung D … +1 more , Kim BJ
J Cosmet Dermatol · 2026 Mar · PMID 41853843 · Full text
BACKGROUND: Lip augmentation is a common cosmetic procedure that requires an objective and validated scale to assess treatment outcomes. Existing lip fullness scales may not be universally applicable across ethnic groups...
BACKGROUND: Lip augmentation is a common cosmetic procedure that requires an objective and validated scale to assess treatment outcomes. Existing lip fullness scales may not be universally applicable across ethnic groups. This study aimed to develop and validate the Humedix Lip Fullness Scale and assess its agreement with the Allergan Lip Fullness Scale. METHODS: A total of 53 females were photographed under standardized conditions. Five dermatologists independently evaluated lip fullness using the Humedix scale and analyzed intra- and inter-rater reliability using Cohen's and Fleiss' Kappa, respectively. The same evaluators reassessed the images using the Allergan scale after 6 months, and agreement between the scales was analyzed using Cohen's Kappa. RESULTS: Intra-rater reliability was perfect (Cohen's Kappa = 1.0000), and inter-rater reliability was high (0.9682, 95% confidence interval: 0.9377-0.9987). Agreement between the Humedix and Allergan scales was strong (Cohen's Kappa = 0.8456, weighted Kappa = 0.9056). CONCLUSION: The Humedix Lip Fullness Scale demonstrated excellent reliability and strong agreement with the Allergan scale, validating its use as an objective tool for assessing lip volume.
Impact of PYCNOGENOL and Pomegranate Extract on Pigmentation and Lightness in Skin of Color: A Pilot Study.
Arunachalam S
J Cosmet Dermatol · 2026 Mar · PMID 41841561 · Full text
Abstract loading — click title to view on PubMed.
Enhanced Effectiveness of Onabotulinum Toxin A in Combination With Definisse KP1 Eye Contour Cream for Upper Face Rejuvenation: A Case Series.
Proietti I, Manni M
J Cosmet Dermatol · 2026 Mar · PMID 41837357 · Full text
BACKGROUND: Among antiaging treatments, botulin toxin A injection is one of the most widely used. KP1 (Serpine A1-III) is a recently developed bioactive peptide that increases collagen type I by enhancing its synthesis a...
BACKGROUND: Among antiaging treatments, botulin toxin A injection is one of the most widely used. KP1 (Serpine A1-III) is a recently developed bioactive peptide that increases collagen type I by enhancing its synthesis and preventing its degradation. AIMS: This case series described the combinatorial effect of onabotulinum toxin A injection with Definisse KP1 eye contour cream application in the treatment of skin aging in the upper third of the face. PATIENTS/METHODS: Adult subjects with moderate to severe dynamic wrinkles who received onabotulinum toxin A combined with Definisse KP1 eye contour cream (Onabotulinum toxin A + KP1 group, hereinafter referred to as + KP1 group) or onabotulinum toxin A alone (Control group) were included in the analysis. The following variables were measured: severity of the disorder, skin hypersensitivity, erythema, oedema, periocular wrinkles, skin quality, hydration-creepiness, and tightness; each parameter was evaluated in both eyes 4 weeks posttreatment. RESULTS: Data from 22 in the + KP1 group and 19 in the Control group were collected. In the + KP1 group, all variables improved, except for eye erythema and eye oedema. Conversely, in the Control group, only eye impairment severity and periocular wrinkles improved from baseline. In the satisfaction questionnaire, the overall evaluation of the protocol achieved higher scores in the + KP1 group than in the Control group. CONCLUSIONS: From this case series, the application of Definisse KP1 eye contour cream seems to enhance the effect of onabotulinum toxin A injection on periocular wrinkles and provide additional benefits in skin quality; the combined procedure was tolerated, feasible, and appreciated by subjects.
RETRACTION: A Randomized, Participant- and Evaluator-Blinded, Matched-Pair, Prospective Study Comparing the Safety and Efficacy Between Polycaprolactone and Polynucleotide Fillers in the Correction of Crow's Feet.
J Cosmet Dermatol · 2026 Mar · PMID 41834780 · Full text
S. Y. Choi, Y. G. Koh, K. H. Yoo, H. S. Han, J. Seok, and B. J. Kim, "A Randomized, Participant- and Evaluator-Blinded, Matched-Pair, Prospective Study Comparing the Safety and Efficacy Between Polycaprolactone and Polyn...
S. Y. Choi, Y. G. Koh, K. H. Yoo, H. S. Han, J. Seok, and B. J. Kim, "A Randomized, Participant- and Evaluator-Blinded, Matched-Pair, Prospective Study Comparing the Safety and Efficacy Between Polycaprolactone and Polynucleotide Fillers in the Correction of Crow's Feet," Journal of Cosmetic Dermatology 24, no. 1 (2025): e16576, https://doi.org/10.1111/jocd.16576. The above article, published online on 23 September 2024 in Wiley Online Library (wileyonlinelibrary.com) has been retracted by agreement between the authors; the journal Editor-in-Chief, Michael H Gold; and Wiley Periodicals, LLC. The retraction has been agreed following the authors' request. The authors informed the journal that a misidentification occurred regarding the dermal filler used in the clinical study. Specifically, the product DLMRO1 dermal filler was misidentified as containing pegylated polycaprolactone (PCL), whereas it is composed solely of pure PCL filler. Because pure PCL and pegylated PCL are distinct materials with different biocompatibility, viscosity, and biodegradation profiles, the misidentification significantly affects the reported methods and undermines the reliability of the study's findings. Accordingly, the article has been retracted.
A Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor-Hair Serum for the Prevention of Chemotherapy-Induced Alopecia.
Mann K, Potluri P, Paul EE … +4 more , Segar JM, Ehsani S, Roe D, Chalasani P
J Cosmet Dermatol · 2026 Mar · PMID 41834767 · Full text
INTRODUCTION: Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations a...
INTRODUCTION: Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for routine clinical use. Keratinocyte growth factor (KGF) has been shown to have cytoprotective effects on human hair follicles and reduce alopecia in preclinical models. We hypothesized that KGF-hair serum (KGF-HS) will prevent CIA. METHODS: We conducted a Simon two-stage, single-arm clinical study in women with early-stage breast cancer (ESBC) scheduled to receive at least four cycles of chemotherapy. The primary outcome was preservation of hair after chemotherapy, whereas secondary measures included patient-reported wig use, comfort, and validated quality-of-life instruments (EORTC QLQ-C30, HADS, and BIS). RESULTS: Twenty patients were evaluable for the primary end point. None achieved meaningful hair preservation. The average duration of treatment of KGF-HS application was 4.6 weeks. CONCLUSION: In this study of women with ESBC receiving chemotherapy, using the KGF-HS did not prevent CIA. There was no statistical difference pre- and post-study BIS, HADS, and EORTC-30 scores. Application of the KGF-HS was reported to be easy, with minimal discomfort, and a non-oily appearance. Patients' ease of use and acceptability of a topical agent for CIA further supports the development of new agents for a more practical and affordable alternative to scalp cooling. TRIAL REGISTRATION: clinicaltrials.gov: NCT04554732.
Correction to "Neuromuscular Electrical Stimulation for Facial Wrinkles and Sagging: The 8-Week Prospective, Split-Face, Controlled Trial in Asians".
J Cosmet Dermatol · 2026 Mar · PMID 41834264 · Full text
Abstract loading — click title to view on PubMed.
Fractional CO2 Laser Versus Micro Needling Radiofrequency for Post Acne Scarring: A Meta-Analysis of RCTs.
Argobi Y, Tobeigei F, Alasiri FI
J Cosmet Dermatol · 2026 Mar · PMID 41821146 · Full text
BACKGROUND: Post-acne scarring is a prevalent dermatological concern with significant impact on quality of life. Fractional CO2 laser (FCL) and microneedling radiofrequency (MNRF) are widely used treatments, but their co...
BACKGROUND: Post-acne scarring is a prevalent dermatological concern with significant impact on quality of life. Fractional CO2 laser (FCL) and microneedling radiofrequency (MNRF) are widely used treatments, but their comparative efficacy and safety require further synthesis. AIMS AND OBJECTIVES: This meta-analysis was conducted to compare the efficacy and safety of FCL versus MNRF in the management of post-acne scarring. METHODS: The analysis included eight randomized controlled trials involving a total of 249 patients. The primary outcomes evaluated encompassed improvement in acne scars, patient satisfaction scores, pain levels, the risk of post-inflammatory hyperpigmentation, and the duration of erythema. RESULTS: FCL demonstrated superior improvement in acne scars (MD: 0.31, 95% CI, 0.13-0.48, p = 0.0005) and higher patient satisfaction (MD: 0.32, 95% CI, 0.10-0.44, p = 0.005) compared to MNRF. However, FCL was associated with significantly higher pain scores (MD: 2.14, 95% CI, 1.90-2.37, p < 0.00001), an increased risk of PIH (RR: 4.44, 95% CI, 2.39-8.26, p < 0.00001), and a longer duration of erythema (MD: 1.72 days, 95% CI, 1.43-2.02, p < 0.00001). MNRF exhibited a more favorable safety profile. CONCLUSION: While FCL offers superior efficacy for post-acne scarring, MNRF provides better tolerability. The choice of treatment should be individualized, considering patient-specific factors such as skin type, pain tolerance, and recovery expectations. Further research with longer follow-up and standardized outcomes is needed.
The Role of MEF2 in Scar Formation and Angiogenesis.
Tao R, Song Y, Yu Z … +5 more , Guo Y, Cao Y, Wang T, Guo P, Yin Y
J Cosmet Dermatol · 2026 Mar · PMID 41814864 · Full text
BACKGROUND: Myocyte enhancer factor 2 (MEF2), belonging to the Minichromosome Maintenance 1, Agamous, Deficiens and Serum Response Factor (MADS) box family with four members (MEF2A-D), plays a pivotal role in the prolife...
BACKGROUND: Myocyte enhancer factor 2 (MEF2), belonging to the Minichromosome Maintenance 1, Agamous, Deficiens and Serum Response Factor (MADS) box family with four members (MEF2A-D), plays a pivotal role in the proliferation and differentiation of various cells, including endothelial cells (ECs) and fibroblasts, as well as in physiological processes such as angiogenesis. Recent research highlights the crucial importance of MEF2 in the formation of hypertrophic scar, indicating its potential significance in scar formation and angiogenesis. However, the underlying mechanisms are still largely unexplored and warrant further investigation. AIMS: This article aims to provide a detailed summary of the connections between MEF2 and both angiogenesis and scar formation, with a focus on elucidating the possible mechanisms by which MEF2 participates in angiogenesis and scar formation. METHODS: Search on the Pubmed using the keywords MEF2, Scar, and Angiogenesis. The retrieval period spanned from January to August 2025. Summarize the viewpoints of the articles and refine the mechanisms and interconnections among MEF2, Scar, and Angiogenesis. RESULTS: Imbalanced regulation of angiogenesis leads to abnormal scar formation. Although the role of MEF2 is not fully understood, it has been hypothesized as follows: MEF2 indirectly influences scar formation by regulating angiogenesis and vascular inflammatory responses, via the MAPK (mitogen-activated protein kinase) signaling pathway and its interplay with vascular endothelial growth factor (VEGF). On the other hand, MEF2 leads to abnormal deposition of extracellular matrix (ECM) and excessive activation of fibroblasts through its involvement in the transforming growth factor-β (TGF-β)/mothers against decapentaplegic (Smad) signaling pathway, ultimately leading to fibrosis and scar formation during the wound healing process. CONCLUSIONS: MEF2 is intimately associated with angiogenesis and scar formation. However, the mechanisms through which MEF2 is involved in these processes remain incompletely understood, necessitating further in-depth research at the genetic and molecular levels. An increasing number of studies suggest that MEF2 holds significant potential in anti-angiogenesis and scar treatment therapies, potentially emerging as a novel target for the treatment of pathological scars in the future.
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