Clinical, Cosmetic And Investigational Dermatology[JOURNAL]
Sun
200 papers
Distribution and Predictors of Skin Diseases in a Multicenter Clinic-Based Cohort Across Four Regions of India.
Tahilani S, Shenoy MM, Chekuri LS … +8 more , Kamat SN, Singh TNR, Thatte SS, Shah SA, Chawda B, Savitha AS, Verberk WJ, Verma J
Clin Cosmet Investig Dermatol · 2026 · PMID 42199311 · Full text
BACKGROUND: Comprehensive multicenter data on the distribution and determinants of skin diseases in India remain limited. We aimed to characterize the burden of dermatological conditions and identify demographic, behavio...
BACKGROUND: Comprehensive multicenter data on the distribution and determinants of skin diseases in India remain limited. We aimed to characterize the burden of dermatological conditions and identify demographic, behavioral, and clinical predictors across four geographic regions. METHODS: A retrospective, observational, multicentric, clinic-based, non-interventional study. About 6169 (including 422 children aged 1-16 years) Patients data were collected from 415 dermatologists databases attending dermatology clinics across the North, South, East, and West regions of India between June and September 2024. Data was collected using standardized case report forms. Skin diseases were classified into seven major categories: fungal, bacterial, viral, parasitic, autoimmune, inflammatory, and allergic; each defined using uniform diagnostic criteria. Logistic regression models identified independent predictors of each disease category. RESULTS: Fungal infections were the most common diagnosis (26.1%), followed by autoimmune (19.4%), inflammatory skin disease (18.4%) and allergic conditions (10.2%). Male sex was associated with higher odds of parasitic (aOR 1.84, 95% CI 1.39-2.45; p < 0.001), bacterial (aOR 1.43, 95% CI 1.15-1.79; p < 0.01), viral (aOR 1.35, 95% CI 1.10-1.67; p < 0.01), and fungal dermatoses (aOR 1.36, 95% CI 1.19-1.55; p < 0.001), and lower odds of inflammatory disease (aOR 0.69, 95% CI 0.60-0.80; p < 0.001). Low income was associated with increased odds of fungal (aOR 1.55, 95% CI 1.20-2.03; p < 0.001), bacterial (aOR 1.74, 95% CI 1.15-2.69; p < 0.05), and viral diseases (aOR 1.60, 95% CI 1.07-2.44; p < 0.05), and lower odds of autoimmune disease (aOR 0.69, 95% CI 0.52-0.92; p < 0.01). Regional differences were observed relative to the East region: inflammatory disease was less frequent in the North (aOR 0.56, 95% CI 0.42-0.76; p < 0.001), while viral disease was more frequent in North, South, and West regions (aORs approximately 2.0-2.7). Allergic disease was more common in the South (aOR 2.06, 95% CI 1.42-3.10; p < 0.001). Older age was modestly associated with autoimmune, allergic, bacterial, and viral disease, while children had a higher burden of parasitic infections. CONCLUSION: In this large clinic-based study of dermatology patients across India, fungal infections were the most frequent diagnosis and disease patterns varied by sex, income, age, and region. These findings highlight substantial sociodemographic and geographic differences among patients seeking dermatologic care and support the need for region-specific prevention and management strategies in clinical practice.
Sebum-Selective 1,726-nm Laser Therapy for Papulopustular Rosacea Associated with Mite Proliferation: A Case Report.
Paichitrojjana A
Clin Cosmet Investig Dermatol · 2026 · PMID 42199310 · Full text
Papulopustular rosacea is a chronic inflammatory condition of the pilosebaceous unit, with an unclear exact cause, but it is thought to involve an exaggerated immune response, persistent inflammation, and possibly an inc...
Papulopustular rosacea is a chronic inflammatory condition of the pilosebaceous unit, with an unclear exact cause, but it is thought to involve an exaggerated immune response, persistent inflammation, and possibly an increased presence of mites on the skin. This is a case report of a 22-year-old woman with papulopustular rosacea treated with a 1,726-nm sebum-selective laser over three sessions. Progressive clinical improvement was observed, with a reduction of inflammatory lesions from 234 at baseline to complete clearance, along with improvement in erythema, flushing, and patient-reported symptoms. density decreased from 58 mites/cm to 12 mites/cm. Treatment was well tolerated, with no adverse events and high patient satisfaction. These findings suggest that sebum-selective laser therapy may offer a non-pharmacologic treatment option for papulopustular rosacea, potentially by modulating sebaceous gland activity. Further studies are needed to confirm efficacy and clarify mechanisms.
Rapidly Progressive Perianal Giant Condyloma in an Immunocompetent Adolescent: An Unusual Abuse-Associated Case.
Achdiat PA, Handayani Y, Avriyanti E … +3 more , Firdaus CP, Fakhrena F, Maharani RH
Clin Cosmet Investig Dermatol · 2026 · PMID 42199309 · Full text
Buschke-Löwenstein tumor (BLT) is a rare, locally aggressive variant of condyloma acuminata associated predominantly with HPV genotypes 6 and 11. It presents as a progressively enlarging, exophytic, verrucous mass in the...
Buschke-Löwenstein tumor (BLT) is a rare, locally aggressive variant of condyloma acuminata associated predominantly with HPV genotypes 6 and 11. It presents as a progressively enlarging, exophytic, verrucous mass in the anogenital region with infiltrative growth and potential for significant local destruction. Predisposing factors include diabetes mellitus, tobacco and alcohol use, pregnancy, chemotherapy, and immunosuppression; however, cases in immunocompetent individuals have been reported. A 15-year-old female presented with an 8.5 cm perianal verrucous mass. She had no comorbidities or conventional risk factors but reported sexual assault 1.5 years earlier. Histopathology confirmed giant condyloma acuminata, and PCR genotyping identified HPV type 11. Laboratory findings, including HIV serology, were unremarkable. Complete surgical excision was performed without complications. At the one-month follow-up after the excision procedure, all lesions had disappeared, and no new lesions had appeared. This case highlights the unusual occurrence of BLT in an immunocompetent adolescent after sexual assault and emphasizes the importance of early recognition, consideration of underlying abuse, and timely management to prevent disease progression.
White Hair-Induced Increased Scalp Visibility: Clinical Implications for Hair Loss Evaluation and Hair Transplantation.
Park JH
Clin Cosmet Investig Dermatol · 2026 · PMID 42199308 · Full text
White hair is a common physiological change with aging; however, in clinical practice, increased scalp visibility associated with white hair is frequently misinterpreted as progression of hair loss. Because white or non-...
White hair is a common physiological change with aging; however, in clinical practice, increased scalp visibility associated with white hair is frequently misinterpreted as progression of hair loss. Because white or non-pigmented hair lacks melanin, hair-scalp contrast is markedly reduced, and some shafts may appear poorly demarcated or even translucent under magnification. Consequently, the scalp may appear more exposed despite preserved hair density and shaft diameter, leading to a clinically meaningful visual illusion. This article highlights white hair-induced increased scalp visibility as a distinct and highly prevalent clinical phenomenon that can confound hair loss evaluation and hair transplantation planning. We discuss the optical basis of scalp show-through, the non-linear relationship between white hair proportion and perceived scalp visibility, and diagnostic pitfalls that may lead to overtreatment. We further analyze procedure-specific technical implications for hair transplantation, including follicular unit dissection in strip surgery (FUT) and harvesting/placement challenges in follicular unit excision (FUE). Finally, based on clinical experience, we present five core principles for dyeing strategy in patients with white hair. The observations presented herein are derived from clinical experience and representative cases; quantitative validation through standardized imaging and blinded assessments remains an area for future investigation.
Corticosteroid Phobia in Patients with Atopic Dermatitis: A Narrative Review.
Chen X, Wang Z
Clin Cosmet Investig Dermatol · 2026 · PMID 42181656 · Full text
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease worldwide, often accompanied by the complex progression of atopic conditions. This article reviews the current state of fear regarding corticosteroi...
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease worldwide, often accompanied by the complex progression of atopic conditions. This article reviews the current state of fear regarding corticosteroid treatment among patients with AD, analyzes the influencing factors and its impact on treatment adherence, integrates epidemiological data and pathogenesis, and examines the clinical advantages and limitations of corticosteroids in AD management. By critically evaluating the effectiveness of existing health education, psychological interventions, and personalized care strategies, this article aims to identify current research gaps and provide evidence-based guidance for optimizing standardized care pathways and improving patient outcomes.
Comparative Effectiveness of Fractional CO Laser and Topical Silicone Gel for Postcesarean Scars.
Wang Y, Chen M, Wei Z … +1 more , Song Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42181655 · Full text
BACKGROUND: Postcesarean scars are common and may cause persistent symptoms and dissatisfaction. Topical silicone gel is widely used as first-line therapy, but its effects are mainly limited to surface hydration and barr...
BACKGROUND: Postcesarean scars are common and may cause persistent symptoms and dissatisfaction. Topical silicone gel is widely used as first-line therapy, but its effects are mainly limited to surface hydration and barrier support. Fractional CO laser, by contrast, induces controlled dermal microinjury and collagen remodeling. Comparative evidence for postcesarean scars remains limited. This study compared the effectiveness of fractional CO laser versus topical silicone gel for improving scar quality, symptoms, and patient satisfaction. METHODS: In this retrospective cohort study, 220 women with postcesarean scars were included (112 treated with fractional CO laser and 108 with topical silicone gel). Both groups received standard postoperative scar care according to routine clinical practice. The primary outcome was scar quality at 6 months assessed by the Vancouver Scar Scale (VSS). Secondary outcomes included pain, pruritus, tightness, satisfaction, and safety. Between-group differences were analyzed using unadjusted comparisons and analysis of covariance adjusting for baseline VSS and time from surgery to treatment. Sensitivity analyses included additional covariate adjustment and propensity score-adjusted models. RESULTS: At 6 months, the laser group was associated with better scar quality compared with the silicone group (VSS total 4.185 ± 1.064 vs 4.619 ± 1.085; unadjusted difference -0.435, = 0.003). After adjustment, fractional CO laser remained associated with a lower VSS total score (adjusted mean difference -0.643; 95% CI -0.891 to -0.395; < 0.001). Significant improvements were also observed in vascularity, pigmentation, and height/thickness. Laser treatment further reduced pain, pruritus, and tightness, and produced higher patient satisfaction (all < 0.001). Adverse events were infrequent and comparable between groups. CONCLUSION: Fractional CO laser was associated with greater improvements in postcesarean scar quality and related symptoms at 6 months compared with topical silicone gel, with a comparable safety profile.
Microneedling Combined with Photothermal-Biomodulated Autologous PRP to Enhance Exosome Release in Refractory Melasma: A Case Report.
Leite Crivelin L, Tomasi-Batiston G
Clin Cosmet Investig Dermatol · 2026 · PMID 42181654 · Full text
Melasma is a challenging condition to treat, requiring multiple therapeutic approaches. Exosomes have been used as regenerative therapies in diverse contexts, including dermatological disorders. A 35-year-old male patien...
Melasma is a challenging condition to treat, requiring multiple therapeutic approaches. Exosomes have been used as regenerative therapies in diverse contexts, including dermatological disorders. A 35-year-old male patient with Fitzpatrick skin phototype II and a longstanding diagnosis of facial melasma, who had undergone multiple prior treatments - including topical agents and laser therapy - with little to no improvement was treated with three monthly sessions of robotic microneedling without radiofrequency on the melasma-affected areas, followed by the injection of preconditioned autologous platelet-rich plasma. The preconditioning consisted of photothermal biomodulation using the Meta Cell Technology technique, applying blue light (467 nm), 1 J/cm, while maintaining the sample at 37°C for 10 minutes. Intradermal injections of 0.25 mL of the autologous product were administered at each demarcated point (1 × 1 cm). After treatment, the patient showed significant improvement in refractory melasma, with lightening of the malar and temporal regions and improved vascularization in the treated areas. This case suggests that intradermal administration of photothermal-biomodulated platelet-rich plasma combined with microneedling may represent a well-tolerated therapeutic alternative for selected patients with resistant melasma.
Dupilumab Can Be Effective for Immune-Related Adverse Event Dermatitis: A Case Report and Review of the Literature.
Mima Y, Yamamoto M, Chiba K … +1 more , Iozumi K
Clin Cosmet Investig Dermatol · 2026 · PMID 42170037 · Full text
Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various malignancies but frequently induce immune-related adverse events (irAEs), among which cutaneous irAEs are the most common. Although syst...
Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various malignancies but frequently induce immune-related adverse events (irAEs), among which cutaneous irAEs are the most common. Although systemic corticosteroids are the mainstay of treatment, some cases are refractory or difficult to manage due to comorbidities. We report a case of refractory irAE dermatitis successfully treated with dupilumab in a patient with atopic dermatitis (AD) in whom corticosteroid escalation was limited by multiple irAEs. A 79-year-old man with AD, well controlled with lebrikizumab, developed disseminated erythematous eruptions consistent with irAE dermatitis following treatment with carboplatin, etoposide, and atezolizumab for stage IVB small cell lung carcinoma. Although the skin lesions initially improved with systemic corticosteroids, they recurred during tapering. Further escalation of corticosteroids was precluded by the development of ICI-associated pneumonitis, hypothyroidism, and adrenal insufficiency. Given the T helper (Th)2-skewed immune background and the limitations of corticosteroid therapy, dupilumab was initiated. Erythema and pruritus improved rapidly, and near-complete remission was achieved after four doses, enabling discontinuation of systemic corticosteroids. Recent evidence suggests that Th2 cytokines, including IL-4 and IL-13, are involved in ICI-associated dermatitis, supporting the mechanistic rationale for IL-4/IL-13 blockade. This case indicates that dupilumab may represent an effective, steroid-sparing therapeutic option for irAE dermatitis, particularly in patients with an atopic background or in those in whom corticosteroid escalation is limited. Further studies are warranted to clarify its efficacy and clinical positioning.
A Case Report of Electrocautery-Assisted Photodynamic Therapy for Subungual Wart with Nail Defects.
Zhao X, Zhu L, Li G … +2 more , Tu X, Cai L
Clin Cosmet Investig Dermatol · 2026 · PMID 42170036 · Full text
Subungual wart with nail defects presents a therapeutic challenge in dermatology. Conventional treatments such as topical medications, cryotherapy, and laser therapy often yield suboptimal outcomes and are associated wit...
Subungual wart with nail defects presents a therapeutic challenge in dermatology. Conventional treatments such as topical medications, cryotherapy, and laser therapy often yield suboptimal outcomes and are associated with high recurrence rates. This report describes the successful management of a refractory case of subungual wart with nail defects using electrocautery-assisted photodynamic therapy (PDT).
Rapid Improvement of Acute Eczematous Facial Dermatitis During Pregnancy Following Stapokibart Therapy: A Case Report.
Zhu Y, Chen J, Wang P
Clin Cosmet Investig Dermatol · 2026 · PMID 42164087 · Full text
BACKGROUND: Acute eczematous facial dermatitis can cause erythema, edema, and severe pruritus, with marked effects on sleep and quality of life. Treatment during pregnancy is challenging because therapeutic options are l...
BACKGROUND: Acute eczematous facial dermatitis can cause erythema, edema, and severe pruritus, with marked effects on sleep and quality of life. Treatment during pregnancy is challenging because therapeutic options are limited by safety concerns. CASE PRESENTATION: This single case report describes a 35-year-old pregnant woman at 9 weeks' gestation who presented with a 10-day history of progressive facial erythema, swelling, and severe pruritus. She had recurrent facial dermatitis, allergic rhinitis, and asthma, supporting an atopic background. Antihistamines and topical corticosteroids were ineffective. Acute eczematous facial dermatitis with atopic features was considered. After risk-benefit assessment and informed consent, stapokibart was initiated with a 600 mg loading dose followed by 300 mg on day 10. RESULTS: Pruritus became minimal within 3 days after the first injection. By day 10, facial erythema and edema had markedly improved; by day 31, the lesions had nearly resolved. EASI decreased from 4.2 to 2 and 1 at day 10 and day 31, respectively; IGA improved from 4 to 2 and 0; pruritus NRS decreased from 8-9 to 3-4 and 0; and DLQI improved from 25 to 7 and 2. No treatment-related adverse events were reported during short-term follow-up. At the time of manuscript preparation, the pregnancy was ongoing at 18 weeks' gestation, with normal prenatal ultrasonography and no reported obstetric complications. CONCLUSION: Stapokibart may provide rapid short-term improvement in selected patients with acute eczematous facial dermatitis with atopic features during pregnancy. During short-term follow-up to 18 weeks' gestation, no treatment-related adverse events or obstetric complications were reported. However, no conclusions regarding maternal or fetal safety can be drawn from this single case, and continued follow-up is essential.
A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation.
Amado R, Al-Mukhtar Y, Lanza E … +8 more , Bove P, Tan T, Abdullah NA, Gökdemir G, Caf N, Karadag AS, Prussia C, Cavallini M
Clin Cosmet Investig Dermatol · 2026 · PMID 42164086 · Full text
INTRODUCTION AND PURPOSE: Anatomic factors and age‑related changes in the midface, along with sun exposure, prolonged television viewing, anemia, and hormonal derangements, contribute to the development of periorbital hy...
INTRODUCTION AND PURPOSE: Anatomic factors and age‑related changes in the midface, along with sun exposure, prolonged television viewing, anemia, and hormonal derangements, contribute to the development of periorbital hyperpigmentation, also known as dark circles. Intradermally injected PN HPT (Polynucleotides High Purification Technology) from trout gonads has an immediate volume-enhancing effect and a longer-term indirect restructuring action on dermal and subdermal tissues. METHODS: Open-label multinational observational cohort of 61 real-life multinational subjects of both genders and unskewed age distribution (mean 41.5 ± 10.5 years, range 20 to 67), with subjectively disturbing dark circles across all Huang subtypes. PN HPT hydrogel (7.5 mg/mL) in phosphate buffer was administered with needle or cannula at baseline (T0), after two to three weeks (second injection, T1), and two to three weeks after T1 (third injection, T2); usually 1 mL on the right periorbicular area and 1 mL on the left (lower doses allowed at the specialist's discretion). Post-treatment follow-up visits: Snapshot photographs were taken at 1 month (T3) and three months after the final T2 injection (T4) and digitally analyzed for color, pigmentation, and outcomes compared with T0 (primary endpoint). Every participating specialist and every treated subject also assessed hyperpigmentation and skin quality categories with GAIS-like scoring scales. RESULTS: Regarding the primary endpoint, the overall picture showed a generalized, highly significant shift toward less severe periorbital hyperpigmentation (p <0.001), especially among needle-treated subjects with the structural subtype. The progressive improvements at T3 and T4 in the evaluated perceptual skin quality categories were also remarkable for both participating specialists and treated subjects. CONCLUSION: The double-edged rationale of low-concentration PN HPT - immediate correction of hollows and tissue loss, and longer-term restructuring of periorbital connective tissues - may be a sound option for improving the appearance of dark circles and the lives of subjects with this aesthetic nuisance.
A Multi-Omics Study of Comorbid Mechanisms Between Depression and Inflammatory Dermatoses Identifies FADS1 and TMEM258 as Therapeutic Targets.
Feng Y, Chen X, Qiu X … +4 more , Zhang R, Cui Z, Mo X, Ju Q
Clin Cosmet Investig Dermatol · 2026 · PMID 42164085 · Full text
BACKGROUND: Emerging evidence indicates a robust association between inflammatory dermatoses and mental disorders, likely driven by their combined impact on health and shared pathogenic mechanisms. PURPOSE: Establishing...
BACKGROUND: Emerging evidence indicates a robust association between inflammatory dermatoses and mental disorders, likely driven by their combined impact on health and shared pathogenic mechanisms. PURPOSE: Establishing the causal relationships between these two types of diseases and investigating their comorbid mechanisms. METHODS: We performed two-sample Mendelian randomization (TSMR) analyses using genome-wide association study (GWAS) summary statistics, examining causal links between six mental disorders and seven inflammatory dermatoses. To elucidate the underlying molecular basis, we implemented an integrative multi-omics framework comprising summary data-based Mendelian randomization (SMR), three-step SMR, TSMR, Bayesian colocalization, gene enrichment analysis and RNA sequencing data analysis. RESULTS: Meta-analysis and multiple testing correction revealed that genetic predisposition to depression increases the risk of psoriasis, while atopic dermatitis is causally associated with a higher risk of depression. Furthermore, we identified 14 genes potentially mediating the comorbidity between inflammatory dermatoses and mental disorders. Functional enrichment analyses and immune cell colocalization suggested the involvement of immunological pathways. Differential expression of several candidate genes was validated in transcriptomic datasets derived from affected tissues. Mediation analyses identified specific mediators and established their causal relationships with the identified genes. Finally, using genetic evidence and druggability assessments, we prioritized the therapeutic potential of these genes. CONCLUSION: Causal relationships exist between various inflammatory dermatoses and mental disorders, with the most significant associations observed between depression and psoriasis, as well as between atopic dermatitis and depression. Fourteen genes are implicated in their comorbid mechanisms, with FADS1 and TMEM258 exhibiting the greatest potential as therapeutic targets.
Post-Market Observational Study of Injectable PLLA Microspheres for Facial Rejuvenation.
Bertossi D, Camporese A, Kefalas N … +8 more , Massidda E, Papagni MF, Patalano Ii M, Quartucci S, Renga MMR, Santorelli A, Sciuto C, Trocchi G
Clin Cosmet Investig Dermatol · 2026 · PMID 42153037 · Full text
PURPOSE: Facial aging and dermal conditions may negatively influence the quality of life, leading patients to seek aesthetic procedures to restore a more satisfying appearance. This post-market observational study invest...
PURPOSE: Facial aging and dermal conditions may negatively influence the quality of life, leading patients to seek aesthetic procedures to restore a more satisfying appearance. This post-market observational study investigates the efficacy and safety of PLLA microspheres (PLLA-LASYNPRO™) in patients affected by chrono-and photoaging and other facial skin conditions. PATIENTS AND METHODS: Ninety-five adult patients affected by chronoaging, photoaging and skin conditions such as oily and acne-prone skin, rosacea, or scarring, were treated with PLLA-based injectable). The patients assessed treatment outcomes through a questionnaire during the sessions and after the end of the treatment. 2D and 3D images were taken for documentation. Physicians assessed the treatment efficacy through the Global Aesthetic Improvement Scale (GAIS) between sessions and at the 6 months follow-up. Adverse events (AEs) were evaluated immediately after the procedure and after 6 months. RESULTS: All treated patients demonstrated visible improvement in facial appearance, with 100% showing GAIS enhancement as assessed by physicians and strong concordance from patient self-evaluations, where satisfaction was reported by 94.7% of respondents, although only 56 patients returned the follow-up questionnaire. Improvements were already present after the first session in 60% of the participants, noted in skin texture, firmness, and elasticity, with progressive enhancement over time. Only mild, transient AEs were reported, such as short-term swelling or localized discomfort, all resolving spontaneously without complications or nodular formation. CONCLUSION: PLLA-LASYNPRO™ proved to be a safe, effective, and well-tolerated injectable bio-regenerator. The treatment achieved high levels of patient satisfaction and compliance, producing natural, gradual, and sustained aesthetic improvements in skin quality and facial contour, particularly in the middle and lower face.
Hyperbaric Oxygen Exposure During the Holding Phase Modulates Early Apoptotic Signaling in Hair Grafts: A Molecular Pilot Study.
Sahan A, Simsek G, Akyurek ME … +3 more , Kucun MK, Erol SS, Arslan S
Clin Cosmet Investig Dermatol · 2026 · PMID 42153036 · Full text
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Laboratory Parameters Can Serve as Objective Auxiliary Tools for Assessing Disease Severity in Hidradenitis Suppurativa: A 5-Year Period Single-Center Retrospective Study.
Wu C, Wang YJ, Liu TJ … +1 more , Jin HZ
Clin Cosmet Investig Dermatol · 2026 · PMID 42153035 · Full text
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disorder. Laboratory parameters may serve as an assessment tool, providing a potential objective window into disease activity. OBJECTIVE...
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disorder. Laboratory parameters may serve as an assessment tool, providing a potential objective window into disease activity. OBJECTIVE: To systematically evaluate the utility of commonly obtained laboratory parameters in the objective assessment of disease severity in patients with HS. METHODS: This single-center retrospective study included patients who were clinically diagnosed with HS, acne inversa, or follicular occlusion triad at Peking Union Medical College Hospital between January 1, 2020, and July 1, 2025. Study data were extracted from clinical examination records and corresponding laboratory test results. Ordinal logistic regression models were constructed to evaluate the associations between laboratory parameters and Hurley stages. Heterogeneity analyses were performed to assess the consistency of these associations across anatomical regions. RESULTS: The study included 1750 clinical visits from 583 HS patients, with a male predominance (85.7%) and a mean age of 31.15±12.11 years. By systematically comparing laboratory parameters across Hurley stages, this study identified significant differences in ten markers, including white blood cell (WBC), neutrophil ratio (NEU%), platelet (PLT), plateletcrit (PCT), mean platelet volume (MPV), hemoglobin (Hb), gamma-glutamyl transferase (GGT), high-density lipoprotein cholesterol (HDL-C), erythrocyte sedimentation rate (ESR), and high-sensitivity C-reactive protein (hsCRP). Ordinal logistic regression analyses demonstrated that WBC, NEU%, PLT, PCT, platelet distribution width (PDW), GGT, ESR, and hsCRP were significantly and positively associated with increasing Hurley stage, while Hb, MPV, and HDL-C exhibited inverse associations. Heterogeneity analysis found that systemic inflammation-related markers (WBC, PDW, ESR, and hsCRP) demonstrated highly consistent associations with HS severity across anatomical locations, while metabolic parameters (HDL-C, triglycerides (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) exhibited significant site-specific heterogeneity. CONCLUSION: This study supports the use of readily available laboratory markers as an objective adjunct to conventional clinical severity assessments, while highlighting the anatomical specificity of HS pathophysiology.
Perceived vs. Clinical Acne Severity: Impact on QoL and Treatment Adherence in Male Military Personnel: A Cross-Sectional Study.
Xu T, Li M, Zhan D … +3 more , Li X, Hu X, Zhou Z
Clin Cosmet Investig Dermatol · 2026 · PMID 42145871 · Full text
BACKGROUND: Acne vulgaris imposes a significant psychosocial burden, which may be intensified when patients' perceived severity diverges from objective clinical grading. Such discordance may be amplified in high-stress p...
BACKGROUND: Acne vulgaris imposes a significant psychosocial burden, which may be intensified when patients' perceived severity diverges from objective clinical grading. Such discordance may be amplified in high-stress populations like military personnel, yet evidence in this cohort remains limited. This study quantified this discordance in male military personnel and evaluated whether subjective or objective severity better predicts quality of life (QoL) impairment and treatment adherence. METHODS: We conducted a cross-sectional, questionnaire-based study at a major military medical center in China from March to July 2025. A total of 300 active-duty male military personnel with acne vulgaris were enrolled. Acne severity was objectively assessed by dermatologists using the Global Acne Grading System (GAGS) and subjectively by patients using a 10-cm visual analog scale (VAS). QoL was measured using the Dermatology Life Quality Index (DLQI). Associations between severity scores, DLQI, sociodemographics, and treatment patterns were analyzed using Spearman's rank correlation, Mann-Whitney -test, Kruskal-Wallis -test, and Chi-square test as appropriate. RESULTS: Significant discordance existed between clinician and patient severity assessments (P<0.001). Clinicians classified severity as mild (39.0%), moderate (52.7%), and severe (8.3%), whereas self-ratings were 12.7% mild, 53.0% moderate, and 34.3% severe; 52.3% of patients overestimated their severity. Self-rated severity correlated more strongly with DLQI impairment than GAGS scores (r=0.314 vs. 0.206, both P<0.001). GAGS scores were primarily associated with impairments in physical symptoms, clothing, and social activities, while self-rated severity correlated significantly with all 10 DLQI domains. Higher DLQI scores were associated with marriage, acne scars, military service of 2-5 years, and persistent symptoms (all P<0.05). A treatment paradox emerged: patients with objectively severe acne sought more interventions but had shorter treatment duration (64% discontinued within ≤1 month, P=0.040), whereas those with subjectively severe acne maintained longer courses (69.9% continued >3 months, P=0.011). CONCLUSION: In military populations, self-perceived acne severity more strongly predicts QoL impairment than objective grading and drives differential treatment engagement. Integrating dual-dimensional assessments and psychological support into military dermatology protocols is essential to optimize acne management.
Comparative Evaluation of Buffy Coat-Derived and Apheresis Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia: Laboratory and Clinical Insights.
Huang C, Wu M, Li Y … +5 more , Tang X, Chen M, Li W, Liu Q, Cai K
Clin Cosmet Investig Dermatol · 2026 · PMID 42145870 · Full text
BACKGROUND: Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. OBJECTIVE: To...
BACKGROUND: Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. OBJECTIVE: To compare buffy coat and apheresis PRP in terms of laboratory characteristics and treatment efficacy in AGA, and to identify predictors of response. METHODS: A retrospective analysis was conducted on 747 PRP preparations (514 buffy coat, 233 apheresis) and 163 AGA patients who were eligible for final analysis after screening (87 buffy coat, 76 apheresis). Laboratory indices and PRP parameters were assessed. Clinical efficacy was evaluated by trichoscopy and patient-reported outcomes. Logistic regression was used to determine independent predictors. RESULTS: Apheresis PRP required greater blood volumes and yielded higher platelet concentration (1242×10/L vs 1079×10/L, P<0.001), total platelet counts, and purity, while buffy coat achieved higher recovery rates. Both methods significantly improved hair density, shaft diameter, and follicular parameters, with no significant differences between groups. Patient-reported improvement was higher in the buffy coat group (51.7% vs 46.1%). Logistic regression identified preparation method (buffy coat: OR=3.41, 95% CI: 1.21-9.65, P=0.021) and treatment frequency (OR=2.01 per session, 95% CI: 1.32-3.07, P=0.001) as independent predictors of response. Sex and platelet concentration showed no significant associations. CONCLUSION: Both buffy coat and apheresis PRP are effective for AGA. Buffy coat PRP was associated with greater subjective improvement despite lower platelet counts, suggesting that platelet number alone does not determine efficacy. Repeated treatments significantly enhance outcomes, highlighting the importance of treatment frequency in PRP therapy.
Deciphering the Causal Links Among Metabolomics, Ageing Phenotypes, and Pathological Scars: A Two-Sample Mendelian Randomization Study.
Wang K, Hou K, Wu M … +1 more , Wu Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42145869 · Full text
BACKGROUND: Hypertrophic scars (HS) and keloids represent pathological outcomes following cutaneous injury, characterized by complex pathogenesis and suboptimal therapeutic outcomes. The interplay between metabolomics an...
BACKGROUND: Hypertrophic scars (HS) and keloids represent pathological outcomes following cutaneous injury, characterized by complex pathogenesis and suboptimal therapeutic outcomes. The interplay between metabolomics and ageing may offer novel intervention targets for scar formation. OBJECTIVE: This study aimed to systematically investigate the causal relationships between blood metabolites, ageing phenotypes (telomere length, epigenetic age), and HS/keloids through Two-sample Mendelian randomization (MR) and Two-step Mediation MR analysis. METHODS: We integrated large-scale GWAS data from European populations, including 1400 blood metabolites (n=8299), telomere length (n=438,351), epigenetic age (n=41,000), HS (2068 cases/465,673 controls), and keloids (4086 cases/1,278,496 controls). Two-sample MR analysis was performed using inverse-variance weighted (IVW) and Wald ratio methods. Steiger's, Cochrane's Q, and MR-Egger tests were applied to exclude reverse causality, heterogeneity, and pleiotropy. Mediation effects of ageing phenotypes were quantified. RESULTS: The study identified 30 metabolites significantly associated with HS and 49 with keloids. Among ageing phenotypes, telomere length showed positive correlations with both scar types, whereas PhenoAge exhibited negative correlations. Key metabolites such as Eugenol sulfate and Phenylacetylglutamate regulated scar formation through dual pathways involving telomere length and PhenoAge. CONCLUSION: This study elucidated the causal metabolite-ageing-scar network through genetic evidence, identifying multiple potential therapeutic targets, including Eugenol sulfate and Phenylacetylglutamate. These findings establish a robust foundation for developing targeted metabolic interventions.
Bidirectional Mendelian Randomization Suggests Causal Effects of 731 Immunophenotypes on Vitiligo Pathogenesis.
Lin Z, Qi R, Deng H … +6 more , Sa R, Chen Y, Huang M, Long Y, Chen G, Duan X
Clin Cosmet Investig Dermatol · 2026 · PMID 42145868 · Full text
PURPOSE: This two-sample Mendelian randomization (MR) study aimed to investigate the causal relationship between 731 immune cell traits and vitiligo. PATIENTS AND METHODS: Genetic variants with genome-wide suggestive sig...
PURPOSE: This two-sample Mendelian randomization (MR) study aimed to investigate the causal relationship between 731 immune cell traits and vitiligo. PATIENTS AND METHODS: Genetic variants with genome-wide suggestive significance ( < 1×10) were used as instrumental variables (IVs). Immune phenotype data were sourced from 3757 European individuals (SardiNIA study), while vitiligo data included 385,538 samples (292 cases, 385,509 controls) from FinnGen (Release 9). Primary causal inference utilized inverse-variance weighted (IVW) regression, supplemented by weighted median, mode-based, and MR-Egger methods for sensitivity analyses. Horizontal pleiotropy and heterogeneity were assessed via MR-Egger intercept and Cochran's Q tests. False discovery rate (FDR) correction was applied, with PFDR < 0.05 considered significant and PFDR < 0.20 considered suggestive. RESULTS: The onset of vitiligo was significantly associated with reduced levels of TD CD4 %T cells (OR = 0.63, 95% CI: 0.51-0.78; PFDR = 0.015, significant) and showed a suggestive association with decreased CD4 expression on HLA DR CD4 cells (OR = 0.65, 95% CI: 0.50-0.85; PFDR = 0.166, suggestive). Conversely, suggestive evidence was found for an association between vitiligo and increased CD28 expression on CD28 CD45RA CD8br cells (OR = 1.37, 95% CI: 1.13-1.65; PFDR = 0.166, suggestive) and with elevated CD8 expression on EM CD8br cells (OR = 1.46, 95% CI: 1.19-1.79; PFDR = 0.091, suggestive). Sensitivity analyses confirmed robustness ( > 0.05). CONCLUSION: We suggest novel causal links between vitiligo and specific immune cell dysregulation, highlighting the pivotal role of adaptive immunity in pathogenesis and informing potential therapeutic targets such as TD CD4 T cells and CD8 T cell subsets.
Immediate Autologous Granular Fat Grafting with Modified Techniques for Chronic Prosthetic Rhinoplasty Infection: A Single-Case Experience.
Yang Q, Zheng H, Wang Y … +3 more , Zheng X, Wu J, Zhao H
Clin Cosmet Investig Dermatol · 2026 · PMID 42137405 · Full text
Managing chronic infection after prosthetic rhinoplasty is clinically challenging. Traditional staged treatment involves prolonged waiting periods, often leading to nasal dorsum collapse, soft tissue contracture, and inc...
Managing chronic infection after prosthetic rhinoplasty is clinically challenging. Traditional staged treatment involves prolonged waiting periods, often leading to nasal dorsum collapse, soft tissue contracture, and increased difficulty of secondary surgeries. Immediate autologous fat grafting after infected implant removal has been reported, but technical limitations such as unstandardized debridement and aggressive fat processing remain. We report a case of a 48-year-old female patient with chronic infection one year after ePTFE prosthetic rhinoplasty, unresponsive to a 2-week course of oral amoxicillin-clavulanate potassium. A single-stage procedure was performed, including complete prosthesis and capsule removal, restricted cavity debridement, and immediate transplantation of minimally processed autologous granular fat (simple gauze filtration without washing/centrifugation) into the original cavity. During one-year follow-up, no signs of infection recurrence were observed, and the nasal dorsum contour remained stable and natural without collapse or deformity. The patient reported satisfaction with the aesthetic outcome and declined further implant-based surgery. This single-case experience suggests that single-stage debridement combined with immediate autologous granular fat grafting may be feasible for carefully selected patients with chronic, localized, low-virulence prosthetic rhinoplasty infection. The modified techniques described (restricted debridement, minimal fat processing, elastic tape fixation) warrant further investigation in larger studies.
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