Clinical, Cosmetic And Investigational Dermatology[JOURNAL]
Sun
200 papers
Impact of Bariatric Surgery on Quality of Life and Psychological Well-Being Among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study.
Alsukait S, Alotaibi H, Alkofide M … +5 more , Madani A, Almalki B, Alshehri NA, Alsergani R, Alzahrani HT
Clin Cosmet Investig Dermatol · 2026 · PMID 42131295 · Full text
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with obesity, substantial psychosocial burden, and symptom-related discomfort. Bariatric surgery achieves sustained weight loss...
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with obesity, substantial psychosocial burden, and symptom-related discomfort. Bariatric surgery achieves sustained weight loss and may improve psychological well-being, yet its effect on HS-related quality of life and symptom burden remains uncertain. OBJECTIVE: To evaluate the association of bariatric surgery with psychological well-being, quality of life, and pain among patients with HS using validated patient-reported outcome measures. METHODS: We conducted a analytical cross-sectional study between January 2024 and January 2025 at King Saud University Medical City, Riyadh, Saudi Arabia. Consecutive adult patients with HS were enrolled after informed consent. Disease severity was assessed using Hurley staging. Participants completed the Dermatology Life Quality Index (DLQI), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and a visual analog scale (VAS) for pain. Outcomes were compared between patients with and without prior bariatric surgery using independent t-tests and general linear models adjusted for age, sex, Hurley stage, and diagnostic delay. RESULTS: Among 135 participants, 77 (57.0%) were female and 15 (11.1%) had undergone bariatric surgery. Patients with prior bariatric surgery had lower mean DLQI (8.13 vs 8.62), PHQ-9 (5.73 vs 7.50), GAD-7 (5.87 vs 6.31), and VAS pain (2.80 vs 3.69) scores than those without surgery; however, these differences were not statistically significant after adjustment (all p>0.05). DLQI correlated positively with PHQ-9 (r=0.334) and GAD-7 (r=0.323), while pain correlated moderately with DLQI (r=0.546; p<0.001). CONCLUSION: In this cross-sectional sample, prior bariatric surgery was not associated with statistically significant differences in quality of life, depressive symptoms, anxiety symptoms, or pain after adjustment. However, patients with prior bariatric surgery showed consistently lower mean scores across these outcomes. Larger prospective longitudinal studies with more detailed surgical subgroup data are needed to determine the magnitude and durability of any potential benefit.
Psychological Wellbeing of Patients with Chronic Spontaneous Urticaria and Its Relation to Their Overall Health-Related Quality of Life.
Saja MF, Alhoqail RH, Alduwayan RA … +4 more , Alsubaie LS, Alhelal LA, Alluhaydan FM, Alotaibi HM
Clin Cosmet Investig Dermatol · 2026 · PMID 42131294 · Full text
PURPOSE: Chronic spontaneous urticaria (CSU) is a chronic skin disease characterized by the appearance of wheals with or without angioedema for more than 6 weeks. Its troublesome symptomatology, recurrent nature, and lon...
PURPOSE: Chronic spontaneous urticaria (CSU) is a chronic skin disease characterized by the appearance of wheals with or without angioedema for more than 6 weeks. Its troublesome symptomatology, recurrent nature, and long-term treatment can be physically, psychologically, and economically challenging to patients adversely affecting their psychological wellbeing and health-related quality of life (HRQoL). This study aimed at (i) measuring the level of anxiety and depression in patients with CSU, (ii) evaluating their HRQoL, and (iii) assessing the relationship between psychological wellbeing and HRQoL in those patients. PATIENTS AND METHODS: In this cross-sectional study, patients with CSU (n=114) were recruited by convenience sampling from the dermatology clinic at King Saud University Medical City (KSUMC) between October 2022 and April 2024. Four datasets were collected from each patient: (i) Sociodemographic, disease-, and medication-related characteristics, (ii) anxiety level using the General Anxiety Disorder 7-Item (GAD-7) Scale, (iii) depression level via the 9-item Patient Health Questionnaire (PHQ-9), and (iv) HRQoL using the Chronic Urticaria Quality of Life Questionnaire (CU-QoL). RESULTS: The mean age was 42 (SD: 12.5) with 90.4% being females. The majority had mild-to-moderate disease activity. Around 8% reported concomitant inducible urticaria while 53.5% reported angioedema. The prevalence of patients with CSU at risk of either Generalized Anxiety Disorder (GAD) or Major Depressive Disorder (MDD) was around 28% for each. Mean CU-QoL score was 35.3 (SD: 23.4). Several factors were shown to be significantly associated with higher anxiety and depression levels as well as lower HRQoL including, disease activity, presence of angioedema, drug allergy, and the use of sedative antihistamines. Multivariable regression analysis identified high anxiety and depression levels as significant independent predictors of lower HRQoL in patients with CSU. CONCLUSION: Clinically significant anxiety and depression are prevalent among patients with CSU and are linked to lower HRQoL in those patients.
Mechanistic Insights into Flavonoids in Cosmetic Applications: Multifunctional Roles and Formulation Considerations.
Guo N, Zhong S, Wang Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42124935 · Full text
Flavonoids are plant secondary metabolites commonly found in fruits and seeds, contributing to color, aroma, and taste. They play key roles in growth regulation, pollinator attraction, and stress defense. Structurally ch...
Flavonoids are plant secondary metabolites commonly found in fruits and seeds, contributing to color, aroma, and taste. They play key roles in growth regulation, pollinator attraction, and stress defense. Structurally characterized by their polyphenolic nature, flavonoids contribute to skin health through multiple mechanisms. These compounds contribute to skin health through well-characterized mechanisms, including inhibition of tyrosinase, scavenging of reactive oxygen species, and modulation of inflammatory signaling pathways such as NF-κB. As a result, flavonoids have demonstrated efficacy in skin whitening, antioxidant defense, anti-inflammatory action, and antimicrobial protection. They also promote skin hydration and elasticity by enhancing epidermal barrier function and stimulating the synthesis of collagen and hyaluronic acid. The multifunctional nature of flavonoids positions them as promising natural alternatives to synthetic cosmetic ingredients, particularly in formulations targeting acne, sensitivity, aging, and pigmentation. Although their cosmetic potential is well supported, challenges such as formulation stability, delivery efficiency, and variation in cutaneous absorption continue to limit their widespread application. This review highlights the diverse applications of flavonoids in cosmetics, underscoring their potential to address key skin concerns while advancing natural product innovation.
Repair of Areolar Defect Following the Excision of Sebaceous Cyst by Applying Kite-Flap: A Case Report and Literature Review.
Jiang N, Xu J, Xie W … +2 more , Hua Y, Ye M
Clin Cosmet Investig Dermatol · 2026 · PMID 42124934 · Full text
We report a case of a 68-year-old female with a 6-year history of a left medial areolar sebaceous cyst, which progressed to 12.5×16.2×8 mm and resulted in a 2.0×1.5 cm defect after complete excision. A modified kite flap...
We report a case of a 68-year-old female with a 6-year history of a left medial areolar sebaceous cyst, which progressed to 12.5×16.2×8 mm and resulted in a 2.0×1.5 cm defect after complete excision. A modified kite flap with an optimized length-to-width ratio (1:1.5) and Y-suturing technique was used for repair. The operation lasted 25 minutes with 1 mL blood loss. Postoperatively, the flap achieved primary healing without complications, and bilateral breast symmetry was preserved (<3 mm diameter difference). At 6-month follow-up, the patient reported 100% satisfaction. This modified technique addresses the core challenges of small areolar defect repair, offering high tissue compatibility, minimal invasiveness, and concealed scarring.
Genetically Predicted Serum miRNAs as Potential Causal Drivers of Atopic Dermatitis: Evidence from Large-Scale GWAS and Clinical Validation.
Xie J
Clin Cosmet Investig Dermatol · 2026 · PMID 42124933 · Full text
BACKGROUND: Although dysregulated microRNAs (miRNAs) are implicated in Atopic Dermatitis (AD), their causal roles remain elusive due to potential confounding and reverse causation. We aimed to systematically identify cau...
BACKGROUND: Although dysregulated microRNAs (miRNAs) are implicated in Atopic Dermatitis (AD), their causal roles remain elusive due to potential confounding and reverse causation. We aimed to systematically identify causal miRNAs for AD and elucidate their underlying mechanisms. METHODS: We conducted a bidirectional two-sample Mendelian randomization (MR) study using large-scale GWAS summary statistics for 2083 miRNAs and AD. The findings were validated using independent trans- and cis-eQTL datasets, and consistency was assessed via correlation analysis. Bayesian colocalization was applied to distinguish pleiotropy from linkage disequilibrium. Downstream targets were analyzed via GO/KEGG enrichment, and clinical relevance was verified using differential expression analysis in two independent patient cohorts (GSE162926 and GSE217232). RESULTS: We identified six circulatory miRNAs causally associated with AD. Notably, miR-1908-5p, miR-148a-3p, miR-133a-3p were identified as a robust risk factor, while miR-125a-5p, miR-181b-5p, let-7e-5p exhibited a protective effect. Colocalization analysis revealed compelling evidence (PP.H4=0.99) for a shared causal variant (rs174561) between miR-1908-5p and AD. Reverse MR indicated no causal effect of AD on these miRNAs. Functional enrichment analyses revealed that downstream targets were predominantly enriched in the PI3K-Akt and MAPK signaling pathways, regulating biological processes critical for skin barrier integrity, wound healing, and oxidative stress response. Crucially, transcriptomic analysis in clinical cohorts corroborated the MR findings, showing significant dysregulation of the identified miRNAs in AD patients. CONCLUSION: This study provides robust genetic and transcriptomic evidence for the causal involvement of specific circulating miRNAs, particularly miR-1908-5p, in AD pathogenesis. These findings offer potential novel biomarkers and therapeutic targets for precision medicine in AD.
Dermatologists' Perspectives on Skincare Routine Trends.
Poelhekken M, van der Bent SAS
Clin Cosmet Investig Dermatol · 2026 · PMID 42116932 · Full text
BACKGROUND: Multi-step skincare routines have become increasingly popular, particularly among adolescents and young adults, driven by social media exposure and commercial marketing. Although individual skincare ingredien...
BACKGROUND: Multi-step skincare routines have become increasingly popular, particularly among adolescents and young adults, driven by social media exposure and commercial marketing. Although individual skincare ingredients have demonstrated efficacy for specific dermatological conditions, evidence supporting the routine use of elaborate multi-step regimens in otherwise healthy skin remains limited. Concerns have been raised regarding potential adverse effects and misinformation, especially among younger users. OBJECTIVE: To explore dermatologists' perspectives on multi-step skincare routines, including perceived risks and benefits, observed complications, and the influence of social media. MATERIAL AND METHODS: A cross-sectional digital survey was distributed to Dutch dermatologists and dermatology residents via the Dutch Society for Dermatology and Venereology. The questionnaire addressed attitudes toward skincare trends, observed dermatoses, implicated ingredients, recommended routine complexity, and perceived social media impact. Associations were analyzed using Fisher's Exact Test, Mann-Whitney -test, and Spearman's rank correlation. RESULTS: A total of 168 respondents participated, including 146 board-certified dermatologists and 22 dermatology residents. Most respondents (91.6%) expressed concern about the popularity of multi-step skincare routines, and 88.1% reported regularly encountering skincare-related skin problems, most commonly irritant eczema, perioral dermatitis, allergic contact dermatitis, and acne exogenica. Retinoids, exfoliating acids, fragrances, and products marketed as natural were frequently mentioned in association with these complaints. Despite concerns, 79.8% acknowledged potential benefits, such as increased awareness of skin health and sun protection. Nearly all respondents identified daily sunscreen use as essential, whereas only 12.5% actively recommended multi-step routines. Social media was perceived as highly influential, with frequent reports of misinformation and delayed medical consultation. CONCLUSION: Dermatologists report substantial concern regarding complex skincare routines, particularly in relation to complications and misinformation among younger users. Although some benefits are recognized, professional recommendations emphasize simplicity and daily sun protection.
Treatment of Generalized Granuloma Annulare with JAK Inhibitors: Systematic Review.
Jaguan D, Gratz BW, Jaguan SI … +1 more , Ehrlich A
Clin Cosmet Investig Dermatol · 2026 · PMID 42111237 · Full text
BACKGROUND: Granuloma annulare (GA) is a rare granulomatous skin condition characterized by well-demarcated, annular, erythematous to skin-colored plaques. Treating GA, particularly generalized GA (GGA), remains challeng...
BACKGROUND: Granuloma annulare (GA) is a rare granulomatous skin condition characterized by well-demarcated, annular, erythematous to skin-colored plaques. Treating GA, particularly generalized GA (GGA), remains challenging due to the lack of FDA-approved therapies and limited large-scale studies. Traditional treatments, including corticosteroids, phototherapy, and systemic agents such as antimalarials and antibiotics, have shown variable efficacy. Recent research highlights the role of the JAK-STAT pathway in GA pathogenesis, leading to interest in JAK inhibitors as a potential treatment. Emerging evidence suggests that JAK inhibitors may reduce inflammation and lesion burden in GGA. This manuscript evaluates the efficacy and safety of JAK inhibitors in the treatment of GGA. RESULTS: Twenty-two studies were included, encompassing 50 patients with GGA. Agents included tofacitinib (n=27), baricitinib (n=11), upadacitinib (n=10), abrocitinib (n=1), and ruxolitinib (n=1). Across reports, most patients had recalcitrant disease with multiple prior treatment failures. Clinical improvement was observed in all patients, with complete response reported in 58.0% (29/50) and partial or near complete response in 42.0% (21/50). Median time to initial response was 5 weeks (IQR 2.75-8 weeks). Relapse occurred in a subset after discontinuation, but lesions often resolved with re-initiation. Adverse events were generally mild and consistent with known JAK inhibitor safety profiles (eg, hyperlipidemia, infections, herpes zoster). CONCLUSION: JAK inhibitors show promise as a targeted therapy for GGA, offering a novel approach for patients with refractory disease. Further studies, including clinical trials, are needed to establish long-term efficacy and safety.
Exploring the Role of Radix Polygalae in Melanogenesis Related to Vitiligo: A Network Pharmacology Analysis with in vitro Validation.
Zhu L, Liang Y, Jiang L … +6 more , Fu C, Dai X, Guo H, Zeng Q, Hu S, Chen J
Clin Cosmet Investig Dermatol · 2026 · PMID 42111236 · Full text
OBJECTIVE: Radix Polygalae is a traditional Chinese herbal medicine with various pharmacological effects, including improvement of cognitive ability, anti-neurodegenerative property, and antiviral property, among others....
OBJECTIVE: Radix Polygalae is a traditional Chinese herbal medicine with various pharmacological effects, including improvement of cognitive ability, anti-neurodegenerative property, and antiviral property, among others. Radix Polygalae was also utilized in the treatment of vitiligo in traditional folk clinics, although its mechanism of action remains unclear. This study investigates the potential active ingredients of Radix Polygalae in the treatment of vitiligo. METHODS: This study screened the potential active ingredients and core target genes of Radix Polygalae in the treatment of vitiligo through network pharmacology, and validated the mechanism of Tenuifolin, the key active ingredient, through the in vitro experiments. RESULTS: We finally identified 10 core target genes: TNF, CASP3, IL-1β, IL-6, ESR1, STAT3, VEGFA, PPARG, ALB, and IL-2. Additionally, we found 7 core active ingredients: Tenuifolin (TEN), N-Acetyl-D-Glucosamine, 1,6-Dihydroxy-3,7-dimethoxyxanthone, 1-Hydroxy-3,7-dimethoxyxanthone, aristolactam a, carvacrol, and cordarine. TEN, which contains the highest number of core target genes, was selected for further investigation of its mechanism. According to our findings, TEN could promote melanin production in pigment cells and skin, as well as induce browning of apple slices. Further investigation showed that TEN reduced the expression of CXCL10 and increased the activity of tyrosinase (TYR), without affecting the pH value or the expression of melanogenesis-related genes (MITF, TYR, TYRP1, and DCT), as well as paracrine factors of ET-1 and VEGF. CONCLUSION: TEN is one of the active ingredients of Radix Polygalae that shows potential in the treatment of vitiligo. It may regulate TYR to promote skin pigmentation.
Integrative Transcriptomic and Single-Cell Analysis Reveals the Role of Autophagy-Related Genes in Psoriasis Pathogenesis.
Zhou Y, Chen B, Chen J … +6 more , Fang L, Zhang L, Dou S, Li F, Huang J, Chen C
Clin Cosmet Investig Dermatol · 2026 · PMID 42111235 · Full text
PURPOSE: Psoriasis is a chronic inflammatory skin disease that is characterized by abnormal keratinocyte proliferation and differentiation. This study aimed to explore potential regulatory mechanisms and key genes relate...
PURPOSE: Psoriasis is a chronic inflammatory skin disease that is characterized by abnormal keratinocyte proliferation and differentiation. This study aimed to explore potential regulatory mechanisms and key genes related to autophagy in the pathogenesis of psoriasis. PATIENTS AND METHODS: We performed pseudotime trajectory analysis and cell communication analysis on psoriasis and normal samples from single-cell RNA sequencing (scRNA-seq) data. Autophagy-related genes identified from scRNA-seq data were intersected with differentially expressed genes derived from the mRNA sequencing data. Protein-protein interaction (PPI) analysis was subsequently applied to identify candidate hub genes. Finally, the expression of these hub genes was validated in clinical cohorts and mouse models, thereby confirming the general applicability of hub genes in a larger patient cohort. RESULTS: AUCell analysis revealed a predominant enrichment of autophagically active cells within the keratinocyte population. Along the keratinocyte differentiation trajectory, both the Renin angiotensin system (RAS) and NOD-like receptor signaling pathways were downregulated. Cell communication analysis revealed enhanced HLA-E-CD94/NKG2A inhibitory signals and weakened KLRK1 activating signals in the psoriatic microenvironment. These alterations are closely associated with mTORC1 hyperactivation-induced autophagy deficiency, which collectively impairs NK cell-mediated immune surveillance. In the imiquimod-induced model, three of the seven candidate hub genes (PKP3, SPRR2B, and KRT6B) were significantly upregulated compared with the controls. Subsequent sequencing and RT-qPCR analyses in the clinical cohort consistently demonstrated the upregulation of PKP3, SPRR2B, and KRT6B, supporting their roles as autophagy-related genes that mediate autophagic processes in psoriasis. CONCLUSION: These findings elucidate the potential mechanisms of autophagy-related genes in keratinocyte dysfunction and inflammatory progression in psoriasis, and may provide potential therapeutic targets against autophagy modulation.
Effectiveness of Abrocitinib in Atopic Dermatitis Presenting with Hand-Foot Eczema and Nail Dystrophy: A Case Report.
Ma A, Deng Y
Clin Cosmet Investig Dermatol · 2026 · PMID 42094859 · Full text
Eczema-associated nail dystrophy is an uncommon but clinically relevant manifestation of atopic dermatitis (AD), which can lead to substantial structural and functional impairment and impose significant therapeutic chall...
Eczema-associated nail dystrophy is an uncommon but clinically relevant manifestation of atopic dermatitis (AD), which can lead to substantial structural and functional impairment and impose significant therapeutic challenges. However, evidence regarding systemic treatment for AD-related nail involvement remains limited. We report a case of AD presenting predominantly with refractory hand and foot eczema and marked nail dystrophy who achieved notable improvement following treatment with the selective Janus kinase 1 (JAK1) inhibitor abrocitinib, with cutaneous symptoms improving within several weeks after dose escalation and both fingernail and toenail abnormalities showing gradual structural recovery over a 12-month follow-up. Furthermore, the treatment was well tolerated throughout the follow-up period. This case suggests that abrocitinib may represent a promising therapeutic option for eczema-associated nail changes in patients with AD.
Thiopurine Methyltransferase Levels and Azathioprine Outcomes in Thai Patients with Cutaneous Autoimmune Diseases.
Pureesrisak P, Kwangsukstid O, Kattipathanapong P … +6 more , Kootiratrakarn T, Sukasem C, Mairiang D, Channakorn W, Phainupong D, Suphannaphong M
Clin Cosmet Investig Dermatol · 2026 · PMID 42094858 · Full text
BACKGROUND: Thiopurine methyltransferase (TPMT) is responsible for the inactivation of azathioprine, and is widely used to treat cutaneous autoimmune diseases. TPMT activity is inherited as an autosomal codominant trait...
BACKGROUND: Thiopurine methyltransferase (TPMT) is responsible for the inactivation of azathioprine, and is widely used to treat cutaneous autoimmune diseases. TPMT activity is inherited as an autosomal codominant trait and ranges from high to undetectable levels in different individuals. Low TPMT activity may result in a higher risk of adverse effects (AEs), whereas high TPMT activity may result in potential treatment failure. OBJECTIVE: To assess TPMT levels in patients with cutaneous autoimmune diseases and evaluate the correlation between TPMT levels and AEs of azathioprine and clinical response in patients with pemphigus. METHODS: A cross-sectional study was conducted in 300 patients with cutaneous autoimmune diseases. Blood samples were collected to identify TPMT levels by ELISA. In 10 patients with the lowest TPMT levels, subsequent PCR analysis for the genotype was performed. RESULTS: Among 300 patients, pemphigus vulgaris was diagnosed in 93 (31%), lupus erythematosus in 93 (31%), pemphigus foliaceus in 39 (13%), bullous pemphigoid in 32 (10.7%), systemic sclerosis in 26 (8.7%), and other diseases in 17 (5.6%). The mean TPMT level was 84.9 ± 30.5 mU/mL. Alcohol consumption significantly correlated with lower TPMT levels (p = 0.005). TPMT levels were not correlated with AEs (p = 0.184). The genotype showed (wild-type) in all 10 patients with the lowest TPMT levels. In the pemphigus group, the TPMT level did not correlate with clinical response (p = 0.363). CONCLUSION: Alcohol consumption resulted in lower TPMT levels. TPMT levels did not correlate with clinical response in the pemphigus group and AEs. These findings provide real-world clinical insight in Thai patients, where routine TPMT screening is not universally implemented, highlighting the need for alternative predictors of azathioprine toxicity.
A Retrospective Analysis of Radiofrequency Microneedling for Melasma Management in the Japanese Population.
Imaizumi A, Fujimaki A, Kumar N
Clin Cosmet Investig Dermatol · 2026 · PMID 42094857 · Full text
BACKGROUND: Melasma is a chronic pigmentary disorder with multifactorial pathogenesis and significant psychosocial impact. Although radiofrequency microneedling has emerged as a dermal-targeting adjunctive therapy, real-...
BACKGROUND: Melasma is a chronic pigmentary disorder with multifactorial pathogenesis and significant psychosocial impact. Although radiofrequency microneedling has emerged as a dermal-targeting adjunctive therapy, real-world evidence regarding its clinical effects and safety is limited. OBJECTIVE: To evaluate the real-world clinical response and safety of POTENZA radiofrequency microneedling for melasma treatment. METHODS: A retrospective observational before-and-after study was conducted at a private dermatology center in Japan. Adult patients with clinically diagnosed melasma who underwent POTENZA radiofrequency microneedling treatment were included in the analysis. Melasma severity was assessed using the modified Melasma Area and Severity Index (mMASI) score. Patient-reported satisfaction, qualitative clinical improvement, and adverse events were analyzed descriptively. RESULTS: A total of 29 female patients (mean age, 45.2 ± 7.9 years) were included in the study. The median baseline mMASI score was 6 (IQR 4-12) and remained 6 (IQR 4-8) after treatment, with no statistically significant difference between the time points (p = 0.16). Overall, 26 patients (89.7%) demonstrated stable or improved mMASI scores post procedure. Percentage-based analyses showed substantial interindividual variability: 27.6% of patients achieved≥25% and ≥30% reductions in mMASI, and 10.3% achieved≥50% reduction. Patient satisfaction was reported in 62.1% of the cases. All patients experienced mild, transient erythema that resolved without sequelae, and no serious adverse events were observed. CONCLUSION: In this real-world study involving Japanese patients, POTENZA radiofrequency microneedling demonstrated a favorable safety profile and provided clinically meaningful improvements in selected patients, supporting its role as a complementary treatment in multimodal melasma management.
Dendrobium and Orchidaceae Plants in Dermatology: A PubMed-Based Bibliometric Analysis and Mechanistic Overview.
Hu J, Sun S, Gao K … +2 more , Deng J, Yu P
Clin Cosmet Investig Dermatol · 2026 · PMID 42094856 · Full text
PURPOSE: Dendrobium ("Shihu") and other Orchidaceae plants have been investigated as adjunctive options for inflammatory dermatoses, wound repair, and topical skin care. However, clinically relevant evidence and safety i...
PURPOSE: Dendrobium ("Shihu") and other Orchidaceae plants have been investigated as adjunctive options for inflammatory dermatoses, wound repair, and topical skin care. However, clinically relevant evidence and safety information remain scattered across phytochemistry, experimental dermatology, biomaterials, and formulation science. This study used bibliometric methods to map publication patterns and identify themes most closely related to dermatologic mechanisms and safety reporting. METHODS: PubMed was searched on January 19, 2026 using a reproducible query that combined Orchidaceae/Dendrobium terms with dermatology and clinical/safety concepts. Records indexed from January 1, 2006 to January 19, 2026 were exported in MEDLINE format and analyzed in R with bibliometrix (v4.3.0) to summarize annual output, contributions by countries and institutions, collaboration networks, source journals, author productivity, and term co-occurrence with burst detection. RESULTS: The final dataset contained 103 records. Annual output increased over time and peaked in 2025 (n=24). China contributed the largest share of publications and occupied a central position in international co-authorship networks. The literature was distributed across 64 journals and covered constituent characterization, experimental models, and delivery/materials-oriented studies. Recent term evolution highlighted growing attention to oxidative stress, signal transduction, and wound repair, whereas safety-related terminology appeared less frequently. CONCLUSION: Research on Orchidaceae-derived constituents relevant to dermatology is expanding, but clinically oriented evidence remains limited and reporting is heterogeneous, particularly with respect to botanical authentication, extract/formulation characterization, clinically interpretable endpoints, and adverse-event documentation. Better clinical translation will require transparent composition reporting and prospective studies that combine mechanism-linked biomarkers with systematic safety assessment.
A Extract Improves Mitochondrial Function in Aging Skin and Promotes Wound Healing.
Tao L, Tai M, Zhou Z … +4 more , Chen Z, Zhang R, Ge Y, Ju Z
Clin Cosmet Investig Dermatol · 2026 · PMID 42088112 · Full text
PURPOSE: This study investigates whether extract (GLE) can enhance mitochondrial function to promote wound healing in aging skin. METHODS: Natural senescent human foreskin fibroblasts (BJ) were treated with varying conc...
PURPOSE: This study investigates whether extract (GLE) can enhance mitochondrial function to promote wound healing in aging skin. METHODS: Natural senescent human foreskin fibroblasts (BJ) were treated with varying concentrations of GLE, and safe concentrations were determined using the cell counting kit-8 (CCK-8) assay. The levels of mitochondrial reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were measured. Animal experiments were conducted to validate GLE's effects on wound healing by assessing adenosine triphosphate (ATP) and ROS levels in skin tissues. RESULTS: GLE exhibited no cytotoxicity within a concentration range of 0-100 µg/mL. Simultaneously treating senescent BJ cells with 50 µg/mL or 100 µg/mL of GLE can significantly enhance cell viability. Treatment with 100 µg/mL GLE significantly increased MMP levels while reducing mitochondrial ROS levels. Hydrogel containing 2% GLE applied to injured skin promoted wound healing, increased the ATP level of the wound tissue, and decreased ROS levels in skin tissues. CONCLUSION: These findings suggest that GLE can improve mitochondrial function in aging skin and promote wound healing.
Genetically Predicted tA (a tRNA-Derived Adenosine Modification) and Risk of Bullous Pemphigoid: A Two-Sample Mendelian Randomization Study.
Yan L, Chen D, Yu D … +1 more , Shen X
Clin Cosmet Investig Dermatol · 2026 · PMID 42079477 · Full text
PURPOSE: Bullous pemphigoid (BP) is an autoimmune blistering disease linked to T-lymphocyte dysregulation. Adenosine deaminase (ADA) and adenosine metabolites modulate T-cell function, suggesting a potential role in BP p...
PURPOSE: Bullous pemphigoid (BP) is an autoimmune blistering disease linked to T-lymphocyte dysregulation. Adenosine deaminase (ADA) and adenosine metabolites modulate T-cell function, suggesting a potential role in BP pathogenesis. However, causal evidence from human genetic studies is lacking. This study aimed to investigate the potential causal associations of genetically predicted levels of ADA, ADA protein, and several adenosine metabolites with the risk of BP and its subtypes (mucous membrane pemphigoid [MMP] and other/unspecified pemphigoid [OUP]). PATIENTS AND METHODS: We conducted a two-sample Mendelian randomization (MR) study using summary statistics from large-scale genome-wide association studies (GWAS). Genetic instruments for ADA levels, ADA protein levels, 5-methylthioadenosine, N1-methyladenosine, N6-carbamoylthreonyladenosine (tA), and N6-succinyladenosine were selected. Outcome data for BP, MMP, and OUP were obtained from the FinnGen R12 release. The primary analysis used the inverse-variance weighted (IVW) method. Sensitivity analyses included MR-Egger, weighted median, weighted mode methods, Cochran's Q test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis. RESULTS: Genetically predicted higher tA levels were significantly associated with a lower risk of BP (IVW OR: 0.37, 95% Confidence Interval [CI]: 0.21-0.66; P < 0.001; P_FDR < 0.001). This association was supported by the weighted median method (OR: 0.39, 95% CI: 0.18-0.86; P = 0.02). No significant evidence of heterogeneity or horizontal pleiotropy was found for this association. No causal associations were observed for other adenosine metabolites, ADA levels, or ADA protein levels with BP, MMP, or OUP after FDR correction. CONCLUSION: This MR study suggests a potential causal association between higher tA levels and reduced risk of bullous pemphigoid. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.
Morbihan Disease May Induce Nonspecific Inflammatory of Extra-Facial Region: A Case Report and Literature Review.
Deng F, Wang P
Clin Cosmet Investig Dermatol · 2026 · PMID 42079476 · Full text
This case describes a 29-year-old man with Morbihan disease, characterized by a 5-year history of recurrent facial erythema, papules, and pustules, followed by persistent right face edema. Initially misdiagnosed as lupus...
This case describes a 29-year-old man with Morbihan disease, characterized by a 5-year history of recurrent facial erythema, papules, and pustules, followed by persistent right face edema. Initially misdiagnosed as lupus erythematosus, he received multiple treatments with only transient relief. Clinical manifestations combined with pathological findings confirmed a diagnosis of Morbihan disease associated with rosacea. Notably, the patient developed erythema and papules on the inner thighs, along with small papules on the trunk and upper limbs for 3 months. A biopsy revealed nonspecific inflammation. Since the morphology of these lesions differed from any known skin disease and no other cause could be identified, we believe this may be a manifestation of the disease. Extra-facial manifestation not previously reported. Various therapies were attempted: doxycycline and azelaic acid improved erythema; baricitinib was ineffective; while omalizumab and intense pulsed light (IPL) achieved partial improvement in erythema and edema. Long-term isotretinoin therapy provided sustained remission without relapse during tapering, confirming its efficacy and safety. This case expands the clinical spectrum of Morbihan disease by documenting extra-facial involvement and reported isotretinoin as an effective long-term therapy, with omalizumab and IPL as promising adjuncts. Furthermore, the literature review (2004-2025) summarizes the clinical features, pathology, and treatment responses of reported cases, showing a male-to-female ratio of 2.81:1. Lymphatic or vascular dilation was significantly correlated with a favorable outcome. Conversely, dermal edema and granuloma were inversely associated with treatment efficacy, indicating poorer prognosis. However, based on uncontrolled data, these findings are strictly hypothesis-generating and do not establish a definitive treatment hierarchy.
Hydroa Vacciniforme: When and How to Suspect It.
Yang C, Zhu R
Clin Cosmet Investig Dermatol · 2026 · PMID 42057801 · Full text
Hydroa vacciniforme (HV) is a rare pediatric photosensitive dermatosis characterized by sun-induced recurrent lesions on exposed areas and subsequent atrophic scarring, with its pathogenesis remaining unclear. This repor...
Hydroa vacciniforme (HV) is a rare pediatric photosensitive dermatosis characterized by sun-induced recurrent lesions on exposed areas and subsequent atrophic scarring, with its pathogenesis remaining unclear. This report aims to improve clinicians' recognition of pediatric HV and provide practical references for its clinical diagnosis and management by detailing a typical case in a young child. We describe a 3-year-old male patient with recurrent erythema, blisters, erosion, crusts, and atrophic scars on the face, nasal dorsum, and auricles for over one year. His skin lesions worsened significantly after sun exposure, alleviated with strict photoprotection, and presented with obvious seasonal variations. A definitive diagnosis of HV was made based on the patient's typical clinical manifestations. The patient was treated with strict sun avoidance, oral vitamin B6, and topical fusidic acid, with notable clinical improvement during follow-up. This case highlights that the definitive diagnosis of pediatric HV relies on typical clinical manifestations combined with the exclusion of relevant differential diagnoses, which is crucial for the early identification and standardized management of this rare disease in young children.
The Genetics of Hidradenitis Suppurativa.
Gupta AK, Dennis DJ, Economopoulos V … +3 more , Magalhaes RF, Saunte DML, Piguet V
Clin Cosmet Investig Dermatol · 2026 · PMID 42057800 · Full text
Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease characterized by painful nodules, abscesses, tunnels, and scarring, with substantial clinical and psychological burden. Genetic studies have...
Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease characterized by painful nodules, abscesses, tunnels, and scarring, with substantial clinical and psychological burden. Genetic studies have revealed that HS has a complex and heterogeneous architecture, encompassing rare monogenic mutations, intermediate-frequency variants, and polygenic risk distributed across multiple loci. Familial aggregation, twin studies, and genome-wide association studies collectively demonstrate that inherited factors contribute substantially to disease susceptibility. Different genetic profiles influence disease onset, severity, and clinical phenotype. Monogenic γ-secretase mutations are associated with early-onset, severe, and extensive disease, whereas polygenic risk shapes heterogeneous presentations and may modify disease trajectory. Genetic variants implicated in HS also intersect with systemic comorbidities including inflammatory bowel disease, spondyloarthritis, coronary artery disease, and diabetes, highlighting shared pathogenic pathways. Mechanistic insights indicate that dysregulated Notch and Wnt/β-catenin signaling; keratinization and epithelial differentiation are central drivers of genotype-informed clinical trials. Despite advances, many variants remain uncharacterized, and polygenic risk scores currently have limited predictive power. Integration of genetic findings with clinical, environmental, and longitudinal phenotypic data is therefore essential to inform risk assessment, patient stratification, and early intervention. This review synthesizes current knowledge on HS genetics, emphasizing genotype-phenotype correlations, comorbidity associations, and translated opportunities, and outlines research priorities needed to advance toward precision medicine approaches for HS.
Cross-Polarized Macro Photography versus Polarized Dermoscopy in Basal Cell Carcinoma: A Blinded Paired-Image Comparison.
Erdem O, Erdemir VA, Dağtaş BB … +7 more , Koku Aksu AE, Ertekin SS, Yilmaz A, Gökyayla E, Gençoğlan G, Göktay F, Gürel MS
Clin Cosmet Investig Dermatol · 2026 · PMID 42051916 · Full text
BACKGROUND: Polarized dermoscopy (PD) is the established non-contact imaging modality for basal cell carcinoma (BCC). Cross-polarized macro photography (CPMP) applies analogous optical principles using widely available e...
BACKGROUND: Polarized dermoscopy (PD) is the established non-contact imaging modality for basal cell carcinoma (BCC). Cross-polarized macro photography (CPMP) applies analogous optical principles using widely available equipment, but its performance relative to PD has not been systematically evaluated. OBJECTIVE: To compare dermoscopic feature visibility, image quality, and expert modality preference between CPMP and PD in BCC using a blinded, paired-image design. METHODS: One hundred paired CPMP and PD images of histopathologically confirmed BCCs, acquired during the same clinical visit, were digitally masked to remove modality-revealing cues and reviewed in randomized side-by-side pairs. Feature visibility was assessed by three dermoscopists; image quality by a multidisciplinary panel using the DIQS-5 (a structured 5-point dermoscopic image quality scale); and modality preference by three dermatologists with varying CPMP familiarity across two blinded rounds with a washout period. RESULTS: Feature visibility did not differ significantly for any established BCC criterion (all P > 0.05). CPMP scored significantly higher for depth of field and color fidelity (both P < 0.001); sharpness was comparable between modalities (P = 0.494). CPMP captured all lesions ≥1 cm in a single frame, whereas 41.5% of large lesions exceeded PD's field of view. The majority of raters preferred CPMP in both evaluation rounds, with phenotype-dependent patterns: CPMP was favored for pigment-rich lesions and PD for lesions with fine vascular structures. CONCLUSION: CPMP demonstrated feature visibility comparable to PD while offering measurable advantages in depth of field, field of view, and color rendering, suggesting complementary roles for these modalities in BCC imaging.
Histopathological Features and p16/p62 Expression as Indicators of High-Risk HPV Co-Infection in Anogenital Condyloma Acuminata.
Usman HA, Primastari E, Achdiat PA … +9 more , Hidayah RMN, Husnayain KI, Hernowo BS, Dewayani BM, Agustina H, Yantisetiasti A, Husain O, Nuraeni N, Trianasari N
Clin Cosmet Investig Dermatol · 2026 · PMID 42046650 · Full text
BACKGROUND: Condyloma acuminata (CA) is primarily caused by low-risk human papillomavirus (LR-HPV); however, high-risk HPV (HR-HPV) co-infection is increasingly reported and cannot be reliably distinguished based on clin...
BACKGROUND: Condyloma acuminata (CA) is primarily caused by low-risk human papillomavirus (LR-HPV); however, high-risk HPV (HR-HPV) co-infection is increasingly reported and cannot be reliably distinguished based on clinical appearance alone. Histopathological assessment and selected immunohistochemical markers may help identify lesions with greater biological risk. OBJECTIVE: To evaluate the association between histopathological features, p16 and p62 expression, and HR-HPV co-infection in anogenital CA. METHODS: This cross-sectional study included 81 histopathologically confirmed CA cases. Semi-quantitative scoring was applied to lesion morphology, keratinization patterns, koilocytosis, atypical mitoses, and lymphocytic infiltration. p16 and p62 expression were assessed immunohistochemically. HPV genotyping was performed using real-time PCR. Variables significant in bivariate analysis were entered into multivariate logistic regression. RESULTS: HR-HPV co-infection was detected in 59.3% of cases, with HPV-16 as the most frequent genotype. Hyperkeratosis (aOR = 4.29; p = 0.039) and atypical mitotic activity (aOR = 14.29; p < 0.001) were independently associated with HR-HPV co-infection. Parakeratosis and koilocytosis showed inverse associations. p16 and p62 were not independent predictors, although p16 block positivity correlated with high p62 expression (p < 0.001). CONCLUSION: Certain histopathological features, particularly atypical mitoses and hyperkeratosis, are associated with HR-HPV co-infection in anogenital CA. Routine histopathological evaluation may therefore provide practical clues to identify lesions that warrant closer clinical attention, while p16 and p62 offer complementary biological information.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe