Clinical, Cosmetic And Investigational Dermatology[JOURNAL]
Sun
200 papers
Differential Clinical Signatures of Vulvar Lichen Sclerosus, Lichen Planus, and Chronic Lichen Simplex: A Comparative Study in 1355 Patients.
Hu Q, Sun K, Liu L … +6 more , He Y, Shao Y, Liu T, Yang K, Yang M, Chang J
Clin Cosmet Investig Dermatol · 2026 · PMID 41878554 · Full text
BACKGROUND: Vulvar lichen sclerosus (VLS), vulvar lichen planus (VLP), and vulvar lichen simplex chronicus (VLSC) are inflammatory dermatoses with overlapping clinical features, posing diagnostic challenges. VLS and VLP...
BACKGROUND: Vulvar lichen sclerosus (VLS), vulvar lichen planus (VLP), and vulvar lichen simplex chronicus (VLSC) are inflammatory dermatoses with overlapping clinical features, posing diagnostic challenges. VLS and VLP carry malignant potential, unlike VLSC. Comparative studies are limited despite frequent misclassification. OBJECTIVE: To compare the clinical characteristics of VLS, VLP, and VLSC and identify distinguishing diagnostic features. METHODS: A retrospective study was conducted on clinical data from patients diagnosed with VLS, VLP, or VLSC at the Beijing Hospital Vulvar Clinic (March 2017-August 2024). Epidemiological data, symptoms, and physical findings were compared. RESULTS: Patients with VLP had a significantly higher median onset age (44 years) than VLS (30 years) or VLSC (34 years) (<0.001). Diagnostic delay was longest in VLS (median 5 years vs 3 years for VLP/VLSC). Pruritus prevalence and intensity (median Numerical Rating Scale [NRS]) were highest in VLSC (100%; NRS 7), followed by VLS (92%; NRS 5) and VLP (60%; NRS 2). Pain was most frequent in VLP (79%) vs VLS (14%) and VLSC (<1%). VLSC patients reported the highest mean Dermatology Life Quality Index scores (8.67), driven by severe pruritus. Sexual dysfunction was common in both VLS (81%) and VLP (85%). Anatomically, VLS primarily affected the clitoris, labia minora, and interlabial sulci; VLSC predominantly involved the labia majora and perianal region. Vaginal introitus involvement characterized VLP (90%). Lesion morphology differed: VLS featured white patches (84%) and lichenification (61%), VLP erosion (76%), and VLSC marked lichenification (89%). CONCLUSION: VLS, VLP, and VLSC exhibit distinct differences in age of onset, clinical manifestations, lesion morphology, and anatomical distribution despite clinical overlap. Recognizing these features facilitates accurate diagnosis, guides individualized treatment, improves long-term outcomes, and enables early detection of malignant potential in VLS/VLP.
Two-Sample Bidirectional Mendelian Randomization Analysis of the Causal Relationship Between Immune Cell Phenotypes and Systemic Lupus Erythematosus.
Niu W, Li J, Jia H … +3 more , Wang L, Xu M, Liu X
Clin Cosmet Investig Dermatol · 2026 · PMID 41878553 · Full text
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Numerous studies suggest that immune cells play a critical role in the onset and progression of SLE; however, the causal mechanisms underlyi...
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Numerous studies suggest that immune cells play a critical role in the onset and progression of SLE; however, the causal mechanisms underlying these associations remain inadequately defined. This study aimed to systematically evaluate, at the genetic level, the potential causal relationships between 731 immune cell phenotypes and SLE using Mendelian randomization (MR), in order to identify potential pathogenic or protective immune biomarkers. METHODS: We utilized summary statistics from genome-wide association studies (GWAS) involving 3757 individuals of European Sardinian ancestry for 731 immune cell phenotypes and a GWAS for SLE comprising 647 cases and 482,264 controls of European ancestry. Single nucleotide polymorphisms (SNPs) significantly associated with immune phenotypes were selected as instrumental variables. The inverse variance weighted (IVW) method was employed as the primary MR analysis, complemented by the weighted median method, MR-Egger regression, simple mode method, and weighted mode method for validation. Sensitivity analyses included Cochran's Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis to assess heterogeneity, horizontal pleiotropy, and robustness. In addition, reverse MR analysis was conducted to explore the potential causal effects of SLE on immune cell phenotypes. RESULTS: A total of 24 immune cell phenotypes were identified to have significant causal associations with SLE, of which six showed positive correlations and eighteen showed negative correlations. These associations primarily involved key immune molecules including HLA-DR, CD25, CD45/CD45RA, CD8, BAFF-R, CD24, CD14, CX3CR1, CD28, CD11b, CD4, CD3, CD27, and CD16. Reverse MR analysis revealed that only IgD⁺ CD24 %B cells exhibited a bidirectional causal relationship with SLE. CONCLUSION: The findings suggest that immune cell phenotypes may contribute to SLE pathogenesis through mechanisms including immune tolerance regulation, self-antigen recognition, and inflammation amplification. Several phenotypes significantly associated with SLE, such as HLA-DR, CD3, CD24, CD25, CX3CR1, CD8, remain insufficiently investigated at the mechanistic level and may serve as promising targets for future basic and clinical research, with potential therapeutic implications and translational value.
Herpes Zoster in a 9-Month-Old Infant Following Maternal Varicella Infection: A Rare Case Report.
Zhuo X, Yang J, Zhao X … +2 more , Han CC, Dai XY
Clin Cosmet Investig Dermatol · 2026 · PMID 41878552 · Full text
Herpes zoster is caused by reactivation of latent varicella-zoster virus (VZV), typically occurring in older adults or immunocompromised individuals, and is rarely seen in infants. We report a rare case of herpes zoster...
Herpes zoster is caused by reactivation of latent varicella-zoster virus (VZV), typically occurring in older adults or immunocompromised individuals, and is rarely seen in infants. We report a rare case of herpes zoster in a 9-month-old infant, likely due to intrauterine exposure to VZV. The patient presented with dermatomally distributed vesicular lesions on the left anterior chest and back. Treatment included intravenous acyclovir, oral antiviral therapy, semiconductor laser therapy, boric acid compresses, and traditional Chinese herbal fumigation.
Gut Microbiota Influence Host Metabolism and Immune Responses in Atopic Dermatitis: A Next-Generation Sequencing-Based Functional Profiling Study.
Blicharz L, Bukowska-Ośko I, Perlejewski K … +7 more , Navarro-López V, Czuwara J, Waśkiel-Burnat A, Samochocki Z, Olszewska M, Rudnicka L, Radkowski M
Clin Cosmet Investig Dermatol · 2026 · PMID 41878551 · Full text
PURPOSE: Gut dysbiosis has been linked to immune imbalance in allergic diseases, but the underlying mechanisms remain unclear. We aimed to verify whether gut microbiota composition is associated with cellular, metabolic,...
PURPOSE: Gut dysbiosis has been linked to immune imbalance in allergic diseases, but the underlying mechanisms remain unclear. We aimed to verify whether gut microbiota composition is associated with cellular, metabolic, and immune pathways in atopic dermatitis. PATIENTS AND METHODS: Fifty adults with atopic dermatitis and 25 sex- and age-matched healthy controls were enrolled. Gut microbiome composition was assessed using V3-V4 16S rRNA sequencing. Functional pathways were inferred from microbiome data using PICRUSt (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States). RESULTS: Despite only subtle differences in microbiota composition between patients with atopic dermatitis and controls, PICRUSt analysis identified significant differences in 149 functional pathways. Key pathways enriched in atopic dermatitis involved signal transduction mediated by protein kinases, as well as carbohydrate and lipid metabolism. Downregulated pathways included those related to energy metabolism, amino acid and nucleotide metabolism, antigen processing, and innate immune responses. In patients with atopic dermatitis, microbial diversity increased with EASI scores and IgE levels, correlating with additional predicted functional shifts. CONCLUSION: Our results suggest that even subtle structural differences in gut microbiota may exert significant functional effects in atopic dermatitis. Altered pathways could contribute to immune imbalance and impaired epidermal barrier function. These findings underscore the importance of incorporating functional analyses into future gut microbiota studies of atopic dermatitis to help identify therapeutic targets, including candidate probiotic strains for supplementation.
Predictive Factors of Early Super-Response to Biologic Agents in Psoriasis: Insights from Real-World Evidence.
Koç Yıldırım S, Ayyıldız SM, Demirel Öğüt N … +3 more , Erbağcı E, Ünal S, Gokyayla E
Clin Cosmet Investig Dermatol · 2026 · PMID 41878550 · Full text
BACKGROUND/OBJECTIVES: The concept of early super-response (ESR) in psoriasis, characterized by rapid and sustained complete skin clearance, has recently gained clinical relevance. However, evidence regarding predictors...
BACKGROUND/OBJECTIVES: The concept of early super-response (ESR) in psoriasis, characterized by rapid and sustained complete skin clearance, has recently gained clinical relevance. However, evidence regarding predictors of ESR remains limited. This study aimed to identify clinical and laboratory factors associated with ESR in patients with psoriasis vulgaris treated with biologics. METHODS: In this retrospective study, 299 patients with psoriasis vulgaris receiving biologic therapy were evaluated. ESR was defined as achieving a PASI 100 response at week 4 and maintaining PASI < 1 through week 48. Demographic, clinical, and laboratory parameters were compared between ESR and non-ESR groups. Variables with p < 0.1 in univariate analyses were entered into multivariate logistic regression to identify independent predictors. RESULTS: Bio-naïve status (OR = 2.16, 95% CI 1.17-3.96, p = 0.013) and higher baseline neutrophil count (OR = 1.26, 95% CI 1.04-1.53, p = 0.016) were independent positive predictors of ESR, while palmoplantar involvement (OR = 0.27, 95% CI 0.13-0.58, p = 0.001) was a strong negative predictor. Smoking (OR = 0.57, 95% CI 0.29-1.11, p = 0.099) showed a borderline negative association, and platelet-to-lymphocyte ratio (PLR) (OR = 1.005, 95% CI 0.999-1.01, p = 0.083) demonstrated a borderline positive effect. At the biologic class level, no statistically significant differences in ESR rates were observed. Moreover, biologic class was not independently associated with ESR in multivariable analyses after adjustment for clinically relevant covariates. CONCLUSION: Bio-naïve status and elevated baseline neutrophil count predicted rapid and sustained complete clearance with biologic therapy, whereas palmoplantar involvement impaired early response. These findings emphasize the prognostic role of baseline inflammatory and phenotypic features in guiding personalized psoriasis management.
Safety and Efficacy of Mesotherapy with Placenta Polypeptide Injection for Moderate-to-Severe Sensitive Skin: A Multicenter, Randomized, Controlled Trial.
Shu C, Zhang XY, Han XF … +3 more , Liu JW, Sun X, Sun QN
Clin Cosmet Investig Dermatol · 2026 · PMID 41878549 · Full text
BACKGROUND: Sensitive skin (SS) is a prevalent condition characterized by cutaneous hyperreactivity and neurosensory inflammation, for which effective treatments remain limited. Placenta polypeptide injection (PPI), rich...
BACKGROUND: Sensitive skin (SS) is a prevalent condition characterized by cutaneous hyperreactivity and neurosensory inflammation, for which effective treatments remain limited. Placenta polypeptide injection (PPI), rich in anti-inflammatory cytokines and growth factors, presents a promising therapeutic candidate. This study aimed to rigorously evaluate the safety and efficacy of mesotherapy with PPI for treating moderate-to-severe SS. METHODS: In this multicenter, open-label, randomized controlled trial, 156 adults with moderate-to-severe SS were randomized (PPI group: control group = 2:1) to receive three sessions of mesotherapy with PPI (4 mL per session at 30-day intervals) or no treatment (control group) over a 90-day period. The primary endpoint was the change in total facial skin hemoglobin content, a proxy measure of cutaneous inflammation, from baseline to Day 90, quantified by a 3D skin analysis system. Safety was monitored through adverse events (AEs) and laboratory assessments. RESULTS: A total of 154 patients were included in the full analysis set (FAS; 103 PPI group, 51 control group). At Day 90, the PPI group demonstrated a significantly greater reduction in skin hemoglobin content compared to the control group (mean change, -1705.82 ± 1808.17 vs -756.65 ± 1493.17; P=0.001). Furthermore, a significantly higher proportion of patients in the PPI group reported aesthetic improvement on the GAIS (88.9% vs 5.9% rated as "improved" to "very much improved"; P < 0.001). The incidence of AEs was comparable between the PPI (5.8%) and control (9.6%) groups (P = 0.376), with no serious AEs reported. CONCLUSION: Mesotherapy with placenta polypeptide injection is an effective and safe treatment for moderate-to-severe sensitive skin, leading to significant reductions in cutaneous inflammation metrics and high rates of patient-reported aesthetic improvement. TRIAL REGISTRATION: This study was prospectively registered at Chinese Clinical Trial Registry (No. ChiCTR2400080988, Date: 20/02/2024).
Evaluation of Atherosclerosis Risk in Patients with Psoriasis.
Celik L, Akray A, Denli Y … +1 more , Aksungur VL
Clin Cosmet Investig Dermatol · 2026 · PMID 41878548 · Full text
BACKGROUND: Psoriasis is a systemic inflammatory disease with a chronic course that is not limited to the skin. Atherosclerosis can cause serious cardiovascular events such as cerebrovascular stroke and myocardial infarc...
BACKGROUND: Psoriasis is a systemic inflammatory disease with a chronic course that is not limited to the skin. Atherosclerosis can cause serious cardiovascular events such as cerebrovascular stroke and myocardial infarction, which can result in death. This study aimed to examine the atherosclerosis risk in psoriasis patients by measuring the carotid intima media thickness (CIMT), an important marker of atherosclerosis. METHODS: The study included 70 plaque psoriasis patients (41 male and 29 female) and 50 healthy volunteers (30 male and 20 female) between the ages of 18 and 65, from the Cukurova University Faculty of Medicine Department of Dermatology who did not use any systemic treatment in the previous 6 months. Clinical parameters were recorded. The presence of subclinical atherosclerosis was investigated by measuring carotid intima-media thickness (CIMT). CIMT was measured manually by the same cardiologist using B-mode ultrasonography. RESULTS: The median value of the CIMT measured individuals in the patient group was 0.8 mm (min: 0.5-max:1.4), and individuals in the control group was 0.6 mm (min: 0.4-max: 0.95). CIMT value in the patient group was statistically significantly higher than in the control group (p<0.001). A statistically significant relationship was found between age, body mass index, cigarette use, waist and hip circumference, HBA1C, total cholesterol, triglycerides, duration. In multivariate linear regression analysis, cigarette use (p = 0.001) and disease duration (p = 0.024) remained significant, while the Psoriasis Area and Severity Index (PASI) showed a trend toward significance (p = 0.071). CONCLUSION: Our study revealed that CIMT value increases in psoriasis patients. It can be said that this increase in CIMT is more serious in the presence of PASI, disease duration and smoking. In conclusion, psoriasis patients-especially those who smoke and those with a longer disease duration-should be regularly investigated and followed up for atherosclerosis.
Social Determinants of Health as a Predictor of Psoriasis Risk: Preliminary Findings from a National Survey.
Lin X, Li C, Wang J
Clin Cosmet Investig Dermatol · 2026 · PMID 41878547 · Full text
BACKGROUND: Social determinants of health (SDOH) profoundly influence disease risk, but their specific relationship with psoriasis remains unclear. This study aimed to examine the association between SDOH with psoriasis...
BACKGROUND: Social determinants of health (SDOH) profoundly influence disease risk, but their specific relationship with psoriasis remains unclear. This study aimed to examine the association between SDOH with psoriasis risk, as well as the mediating role of metabolic syndrome. METHODS: We analyzed data of 16,083 adults participating in the 2003-2006 and 2009-2014 National Health and Nutrition Examination Survey. A composite SDOH score (range 0-8) was constructed from eight subcomponents across five domains: economic stability, neighborhood and built environment, education, social context, and healthcare access. The association between the SDOH score and psoriasis was assessed using multivariable logistic regression, and a mediation analysis was conducted to quantify the contribution of metabolic syndrome. RESULTS: The overall prevalence of psoriasis was 2.46%. Restricted cubic spline curves indicated a non-linear relationship between SDOH and psoriasis. Piece-wise regression analysis indicated that the odds ratios (95% confidence intervals) for SDOH of 0-2, 3-5 and 6-8 were 0.57 (0.35-0.94), 1.13 (0.93-1.36), and 0.48 (0.36-0.63), respectively. The protective effect of a higher SDOH for psoriasis risk was stronger in participants taking statins (P for interaction = 0.03). Mediation analysis indicated that metabolic syndrome explained a modest yet significant 5.92% (95% CI 1.43-20.63%) of the association. CONCLUSION: The SDOH score exhibits a non-linear association with psoriasis risk in US adults, which is partially mediated by metabolic syndrome. These findings underscore the complex role of socioeconomic and environmental factors in psoriasis etiology. Future prospective studies are needed to establish temporality and assess whether SDOH-targeted interventions can mitigate psoriasis risk.
Effectiveness of 308-nm Excimer Light with Pimecrolimus and Crisaborole in Pediatric Vitiligo: A Retrospective Study.
Ye L, Gao Y, Lu Y
Clin Cosmet Investig Dermatol · 2026 · PMID 41878546 · Full text
PURPOSE: To systematically evaluate the efficacy and safety of 308-nm excimer light therapy combined with topical pimecrolimus cream and crisaborole ointment in children with non-segmental vitiligo, using dermatoscopy, I...
PURPOSE: To systematically evaluate the efficacy and safety of 308-nm excimer light therapy combined with topical pimecrolimus cream and crisaborole ointment in children with non-segmental vitiligo, using dermatoscopy, ImageJ software, Wood's lamp examination, and a color difference meter. PATIENTS AND METHODS: A retrospective study was conducted involving 120 pediatric patients diagnosed with non-segmental vitiligo who attended the Department of Dermatology, The Second Affiliated Hospital of Wenzhou Medical University, between January 2023 and December 2023. Patients were divided into three groups based on treatment regimen. Group 1 received 308-nm excimer light therapy combined with pimecrolimus cream. Group 2 received 308-nm excimer light therapy combined with crisaborole ointment. Control group received 308-nm excimer light therapy. Baseline images of skin lesions were obtained under natural light, Wood's lamp illumination, and dermatoscopic examination. All patients received once-weekly phototherapy sessions for 12 consecutive weeks, with treatment efficacy assessed at 4-week intervals. Treatment response rates, adverse events, and repigmentation patterns were systematically evaluated and compared across treatment groups. RESULTS: The overall treatment efficacy and repigmentation area demonstrated a progressive increase with successive treatment cycles. After 4 weeks of therapy, the response rates for Group 1, Group 2, and the control group were 34.1%, 32.1%, and 23.8%, respectively, with no statistically significant difference observed (P > 0.05). After 8 weeks of treatment, the response rates increased to 63.4%, 60.2%, and 42.8%, respectively, with statistically significant differences among groups (P < 0.05). Following 12 weeks of treatment, the response rates for Group 1, Group 2, and the control group further increased to 76.8%, 71.7%, and 54.8%, respectively (P < 0.05). The combination therapy groups exhibited significantly higher efficacy rates compared with the phototherapy-only group. Clinical efficacy varied significantly across different anatomical sites (P < 0.05), with the highest treatment response observed in the face and neck, followed by the trunk, extremities, and acral regions. Regarding treatment safety, no statistically significant differences in the incidence of adverse reactions were observed between the combination therapy groups and the phototherapy-only group (P > 0.05). CONCLUSION: With increasing treatment duration, the therapeutic efficacy and repigmentation area of vitiligo lesions show a progressive improvement. The combination of 308-nm excimer light therapy with topical pimecrolimus cream and crisaborole ointment demonstrates favorable efficacy in pediatric vitiligo, with only mild and well-tolerated adverse reactions. The integrated use of dermatoscopy, ImageJ software, Wood's lamp examination, and a color difference meter provides an objective, quantitative, and reproducible approach for digitally documenting changes in lesion color and area before and after vitiligo treatment.
Efficacy and Safety of Polycaprolactone Filler in Nonsurgical Rhinoplasty: A Pilot Study.
Huang H, Zhang H, Jin J
Clin Cosmet Investig Dermatol · 2026 · PMID 41878545 · Full text
BACKGROUND: Nonsurgical rhinoplasty (NSR) is rapidly gaining popularity due to its convenience and lower complication risks. Polycaprolactone (PCL)-based collagen stimulator provides both immediate volumization and long-...
BACKGROUND: Nonsurgical rhinoplasty (NSR) is rapidly gaining popularity due to its convenience and lower complication risks. Polycaprolactone (PCL)-based collagen stimulator provides both immediate volumization and long-term neocollagenesis. However, evidence regarding its clinical use in NSR is limited. This study aimed to evaluate the efficacy and safety of PCL-based filler in NSR. METHODS: We conducted a single-center, prospective study in which patients received PCL-based filler injection at baseline, followed by a supplementary treatment at 3 months. All participants were followed for at least 6 months. Outcomes were assessed using nasal anthropometric measurements, Visual Analog Scale (VAS), Global Aesthetic Improvement Scale (GAIS), and Rhinoplasty Outcome Evaluation (ROE). Repeated measures were analyzed with generalized estimating equations (GEE). RESULTS: A total of 10 patients were enrolled, all of whom completed treatment and follow-up. Compared with baseline, VAS and ROE scores showed statistically significant improvement at all post-treatment time points (P < 0.001). GAIS consistently indicated "much improved" or "very much improved" outcomes by both physicians and patients. Objective measurements demonstrated increased nasal length, height, depth, and tip projection, along with decreased nasal width and base width, suggesting enhanced nasal three-dimensional morphology. No adverse events were observed during the study period. CONCLUSION: In this pilot study, PCL-based filler achieved significant and sustained improvements in nasal morphology and satisfaction. These findings support its clinical value as a safe and effective filler for nonsurgical nasal augmentation, warranting further confirmation in larger, multicenter studies with longer follow-up.
Safety and Efficacy of Hyaluronic Acid-Based Filler for Neck Wrinkles: A Prospective, Multicenter, Randomized, Parallel-Controlled Non-Inferiority Trial.
Jiang M, Cheng H, Li Y … +4 more , Ai H, Li J, Liang Y, Xu W
Clin Cosmet Investig Dermatol · 2026 · PMID 41873431 · Full text
BACKGROUND: Horizontal neck lines are an early and conspicuous marker of cutaneous aging. Intradermal hyaluronic acid (HA) injections have become a standard minimally invasive countermeasure, yet comparative data for com...
BACKGROUND: Horizontal neck lines are an early and conspicuous marker of cutaneous aging. Intradermal hyaluronic acid (HA) injections have become a standard minimally invasive countermeasure, yet comparative data for composite HA solutions in Asian populations remain scarce. PURPOSE: To evaluate the efficacy and safety of injectable sodium hyaluronate composite solution (NCTF 135 HA) compared with injectable sodium hyaluronate composite solution (HEARTY) for the correction of moderate-to-severe neck wrinkles. METHODS: In this prospective, multicenter, randomized, evaluator-blinded, active-controlled, non-inferiority trial, 188 subjects with moderate-to-severe neck wrinkles were randomly assigned (1:1) to the experimental group or the control group, with both groups receiving three sessions of non-cross-linked injectable sodium hyaluronate composite solution at 4-week intervals. Improvement of Allergan Transverse Neck Lines Scale (ATNLS), subject-assessed Global Aesthetic Improvement Scale (GAIS) and adverse events (AEs) were evaluated and compared before the 3 injection sessions and at 4, 12, and 24 weeks post-final injection. RESULTS: At week 4 post-final injection, the ATNLS response rates were 88.30% in the experimental group and 85.11% in the control group, respectively, with a between-group difference of 3.19% (95% confidence interval (CI): [-0.0723, 0.0987], = 0.5410), demonstrating non-inferiority of the experimental treatment to the active control. Among the secondary endpoints, neither ATNLS response rates at additional time points nor subject-assessed GAIS responder rates showed statistically significant differences between groups. A total of 128 adverse events were reported, with no statistically significant difference between groups: 26 (27.66%) in the experimental group and 38 (40.43%) in the control group. No device- or procedure-related serious adverse events occurred. CONCLUSION: Injectable sodium hyaluronate composite solution (non-cross-linked) provides safe, effective, and non-inferior correction of moderate-to-severe neck wrinkles compared with active control, expanding minimally invasive therapeutic options for cervical rejuvenation.
Effectiveness and Safety of Antidiabetic Medications in Hidradenitis Suppurativa: A Systematic Review.
Almukhadeb E, AlKanaan R, Alajlan A … +5 more , Alqefari AN, Albawardi FA, Almarshoud G, Alsanad L, Almazrou RK
Clin Cosmet Investig Dermatol · 2026 · PMID 41869434 · Full text
PURPOSE: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition often linked with metabolic dysfunction and insulin resistance. Antidiabetic medications have been explored as adjunctive therapies due to t...
PURPOSE: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition often linked with metabolic dysfunction and insulin resistance. Antidiabetic medications have been explored as adjunctive therapies due to their anti-inflammatory and anti-androgenic effects. This systematic review evaluated the effectiveness and safety of antidiabetic agents in HS management. PATIENTS AND METHODS: A comprehensive search was conducted in PubMed, Scopus, Web of Science, CINAHL Ultimate, and Google Scholar. Eligible studies assessed the efficacy or safety of antidiabetic drugs in HS patients. Fifteen studies, comprising 3721 participants, met inclusion criteria. RESULTS: Metformin was the most studied drug, included in 10 studies. Several investigations showed reductions in HS lesion counts, flare frequency, and disease severity scores (Hurley stage, Sartorius score, Visual Analog Scale). Quality of life improvements, measured by the Dermatology Life Quality Index (DLQI), were observed with metformin, liraglutide, and tirzepatide. Gastrointestinal side effects were the most frequently reported, particularly with metformin. However, no severe or unexpected adverse events were linked to GLP-1 receptor agonists or SGLT2 inhibitors. CONCLUSION: Overall, antidiabetic medications, especially metformin and GLP-1 receptor agonists, appear beneficial for HS. They may reduce disease severity and improve quality of life while maintaining a favorable safety profile. Nevertheless, additional high-quality randomized controlled trials are urgent to confirm these findings.
Cutaneous Tuberculous Sinus Tract: A Case Report.
Gu J, Chen S, Ye M … +4 more , Tian Y, Chen X, Cheng H, Li T
Clin Cosmet Investig Dermatol · 2026 · PMID 41869433 · Full text
An 88-year-old female patient presented with a persistent ulcer in the right flank region following incision and drainage of an abscess. After the relevant examinations and debridement procedures, a deep internal sinus t...
An 88-year-old female patient presented with a persistent ulcer in the right flank region following incision and drainage of an abscess. After the relevant examinations and debridement procedures, a deep internal sinus tract approximately 2-3 cm in length was discovered, extending to the lateral border of the external intercostal muscles. Based on local histopathological examination including the tuberculosis PCR, the condition was diagnosed as a cutaneous tuberculous sinus tract caused by Mycobacterium tuberculosis infection. Cutaneous tuberculosis is a relatively uncommon form of extrapulmonary tuberculosis, primarily affecting the skin and subcutaneous soft tissues. The patient has recovered well following an anticipated nine-month course of triple anti-tuberculosis therapy without pyrazinamide. To date, no literature reports have documented persistent deep skin fistulas resulting from this disease.
A Novel Continuous Buried-Suture Approach for Double Eyelid Blepharoplasty.
Cao Z, Yu L, Wang ZH … +1 more , Shan XJ
Clin Cosmet Investig Dermatol · 2026 · PMID 41869432 · Full text
BACKGROUND: Double-eyelid surgery is one of the most commonly performed cosmetic procedures in East Asia. The two main techniques include mini-incisional buried suture methods and incision-based operations. Mini-incision...
BACKGROUND: Double-eyelid surgery is one of the most commonly performed cosmetic procedures in East Asia. The two main techniques include mini-incisional buried suture methods and incision-based operations. Mini-incisional approaches are favored due to their minimal scarring and rapid recovery. Despite numerous modifications aimed at achieving a natural appearance, complications such as loosening of the double eyelid fold and suture granulomas resembling chalazion remain challenging. To address these issues, we developed a modified continuous single-knot buried suture technique that extends the operative site from the skin to the conjunctiva, thereby establishing a stronger and more durable adhesion. METHODS: Between April 2022 and August 2023, 40 patients (80 eyes) underwent double-eyelid surgery using this novel mini-incisional buried suture technique. Concurrent epicanthoplasty was performed in 39 patients when indicated. Outcomes were assessed based on preoperative and postoperative measurements of upper eyelid movement distance (ULMD) and cosmetic results. RESULTS: All patients were followed for 5 to 24 months. Thirty-eight patients expressed satisfaction with their aesthetic outcomes following the initial procedure. No cases of double-eyelid loss or corneal injury were observed. The mean ULMD significantly increased from 9.13 ± 1.10 mm preoperatively to 9.86 ± 0.96 mm at 5 months postoperatively ( 0.05). Both patients and surgeons rated the aesthetic outcomes as excellent or good. CONCLUSION: This modified procedure is simple,effective with limited adverse effects for establishing a long-lasting double eyelid and providing satisfactory aesthetic results.
Successful Treatment of Concurrent Bullous Pemphigoid and Psoriasis Vulgaris with Abrocitinib: A Case Report and Literature Review.
Hu YQ, Zhang JZ, Zhao Y
Clin Cosmet Investig Dermatol · 2026 · PMID 41869431 · Full text
Bullous pemphigoid (BP) and psoriasis are common immune-related dermatosis. The concurrence of these two diseases is rare. The coexistence of the two conditions imposes a difficult therapeutic challenge. We reported a ca...
Bullous pemphigoid (BP) and psoriasis are common immune-related dermatosis. The concurrence of these two diseases is rare. The coexistence of the two conditions imposes a difficult therapeutic challenge. We reported a case of concurrence of BP and psoriasis vulgaris which was successfully treated by abrocitinib. Based on our research, abrocitinib appears to be an effective and safe therapeutic option for patients with concurrent BP and psoriasis.
Aquagenic Palmoplanta keratoderma: Response to Topical Pimecrolimus and Literature Review.
Shan J, Chen R
Clin Cosmet Investig Dermatol · 2026 · PMID 41869430 · Full text
Aquagenic palmoplantar keratoderma (APK) is a rare skin disease characterized by temporary papules and macerated plaques triggered by contact with water. Failure to receive timely and proper treatment may seriously damag...
Aquagenic palmoplantar keratoderma (APK) is a rare skin disease characterized by temporary papules and macerated plaques triggered by contact with water. Failure to receive timely and proper treatment may seriously damage the patient's daily life. The precise pathogenesis of APK (Aquagenic Palmoplantar Keratoderma) remains poorly understood, and safe and efficacious therapeutic options are currently lacking. The conventional therapy mainly involves topical application of aluminum chloride, followed by botulinum toxin injection, topical corticosteroids, topical salicylic acid, barrier agents, and oral antihistamines. This case report presents an APK patient who showed improvement after tw1o months of treatment with pimecrolimus cream, slight symptom recurrence following water exposure or sweating.
Peripheral Nerve Ultrasound Findings in Leprosy: A Scoping Review of Echogenicity, Cross-Sectional Area, and Vascularization Across 15 Studies.
Gunawan H, Khairuddin R, Hidayah RMN … +3 more , Nugraha HG, Kuntara A, Amalia F
Clin Cosmet Investig Dermatol · 2026 · PMID 41869429 · Full text
BACKGROUND: Leprosy is a chronic granulomatous disease caused by and , primarily affecting the skin and peripheral nerves. Neuropathy in leprosy can result in significant disability, making early detection crucial. Ultr...
BACKGROUND: Leprosy is a chronic granulomatous disease caused by and , primarily affecting the skin and peripheral nerves. Neuropathy in leprosy can result in significant disability, making early detection crucial. Ultrasound offers a non-invasive method to detect neuropathy by assessing echogenicity, cross-sectional area (CSA), and peripheral nerve vascularity. OBJECTIVE: This review aimed to map and synthesize diagnostic role of peripheral nerve ultrasound, focusing on echogenicity, cross-sectional area, and vascularization, in detecting leprosy-related neuropathy. METHODS: This scoping review was conducted in accordance with the PRISMA-ScR guidelines and included 15 studies assessing echogenicity, CSA, and vascularity in leprosy patients (sample sizes ranging from 20-308 participants). RESULTS: Ultrasound consistently identified nerve abnormalities across 15 studies, including hypoechogenicity and fascicular pattern loss (up to 72% of nerves), CSA enlargement, and Doppler vascularity (11-45%) correlating with active inflammation. Reported CSA cut-offs (10-50 mm) yielded sensitivities of 63-90% and specificities of 67-100% across studies. Ultrasound demonstrated superior sensitivity over clinical palpation and nerve conduction studies for subclinical neuropathy detection. CONCLUSION: This scoping review demonstrates ultrasound's utility for early leprosy-related neuropathy detection. Ultrasound shows superior sensitivity over clinical palpation for subclinical involvement, particularly valuable for household contacts and pure neural leprosy. However, methodological heterogeneity precludes definitive diagnostic thresholds. Future research should standardize protocols and validate ultrasound parameters to optimize clinical application and disability prevention in endemic regions.
Upadacitinib for the Treatment of Systemic Immune Co-Morbidity in One Case: Alopecia Areata, Vitiligo, Ankylosing Spondylitis, and Allergic Rhinitis-Asthma - Multifaceted Control.
Li M, Wang X, Chen J … +2 more , Deng T, Lian C
Clin Cosmet Investig Dermatol · 2026 · PMID 41869428 · Full text
BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) often coexist, but treatment options for multi-system comorbidities are limited. This report evaluated the efficacy and safety of the selective JAK1 inhibitor upa...
BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) often coexist, but treatment options for multi-system comorbidities are limited. This report evaluated the efficacy and safety of the selective JAK1 inhibitor upadacitinib (UPA) in a patient with refractory alopecia areata (AA), vitiligo, ankylosing spondylitis (AS), and allergic asthma-nasal syndrome comorbidity. CASE PRESENTATION: A 52-year-old male patient, who had not responded to previous treatments including glucocorticoids, immunosuppressants, and biologics, received UPA (15 mg once daily) for 12 weeks. After treatment, all systemic symptoms significantly improved: the Severity of Alopecia Tool (SALT) score for AA decreased from 15 to 0.9, the vitiligo lesions re-colored and stabilized, spinal joint mobility increased, and the frequency of nasal and asthma attacks decreased. The serum total IgE level decreased from 295 ng/mL to 243 ng/mL. CONCLUSION: UPA achieved rapid and simultaneous improvements in this patient with refractory multi-system immune comorbidity. A transient liver function abnormality (ALT 478.6 U/L, AST 167 U/L) occurred during treatment, which was considered related to concomitant medication and resolved spontaneously after close monitoring and maintenance of the original regimen. This case suggests that UPA is effective for such complex comorbidities and has controllable safety under monitoring, providing a clinical basis for the "targeting upstream common pathways" strategy.
Differential expression of Wnt5a and β-Catenin in Keratoacanthoma, Verrucous Carcinoma and Well-Differentiated Squamous Cell Carcinoma.
Zhang Y, Bai X, Ning X … +1 more , Ren J
Clin Cosmet Investig Dermatol · 2026 · PMID 41869427 · Full text
BACKGROUND: Verrucous carcinoma (VC) are always considered to be a variant of well-differentiated squamous cell carcinoma (SCC). If Keratoacanthoma (KA) is a variant of well-differentiated SCC, it is controversial curren...
BACKGROUND: Verrucous carcinoma (VC) are always considered to be a variant of well-differentiated squamous cell carcinoma (SCC). If Keratoacanthoma (KA) is a variant of well-differentiated SCC, it is controversial currently. Both β-catenin and Wnt5a are key factors in the classical and non-classical Wnt signaling pathways, which are often used in the differential diagnosis of benign and malignant tumors. However, the expression of these two factors in these three diseases remains unclear. The goal of the current study was to explore the expression of β-catenin and Wnt5a in KA, VC, and well-differentiated SCC and to determine their value in differential diagnosis. METHODS: Twenty samples were collected from VC lesions, 30 from KA lesions, and 30 from cutaneous well-differentiated SCC lesions. The expression of Wnt5a and β-catenin in paraffin-embedded tissue sections was analyzed by immunohistochemistry. The histo (H) score was used to evaluate positive cases. RESULTS: There were no statistically significant differences in sex or age between KA, VC, and well-differentiated SCC patients (>0.05). Immunohistochemical analysis showed that β-catenin was expressed in all tissues. For Wnt5a and β-catenin staining intensity, H score and H-score category, there were significant differences between the well-differentiated SCC and KA groups, as well as VC and KA groups (<0.01 for all). However, there were no differences between the well-differentiated SCC and VC groups (>0.05). CONCLUSION: In this study, the differential expression of Wnt5a and β-catenin suggests that the benign tumor KA and well-differentiated SCC may be two distinct entities. We identified that Wnt5a and β-catenin could be used as adjuvant immunohistochemical markers for the differential diagnosis of KA from well-differentiated SCC.
Systemic Contact Dermatitis Triggered by Benzalkonium Chloride in Laundry Detergent A Case Initially Misdiagnosed as Eczema.
Yu M, Meng F, Tian S
Clin Cosmet Investig Dermatol · 2026 · PMID 41869426 · Full text
This case shows that benzalkonium chloride is an important sensitizer for contact dermatitis.The patient did not respond to conventional eczema treatment. Pathological examination and detailed history-taking revealed tha...
This case shows that benzalkonium chloride is an important sensitizer for contact dermatitis.The patient did not respond to conventional eczema treatment. Pathological examination and detailed history-taking revealed that benzalkonium chloride in the detergent was the causative factor. After avoiding exposure to this allergen, the condition improved, emphasizing the need to consider contact dermatitis in patients with refractory eczema.
About
- Frequency
- Sun
- Papers found
- 200
- RSS feed
- Subscribe