Indian Journal Of Pediatrics[JOURNAL]

Sepsis in young infants can lead to high mortality and morbidity, and its nonspecific signs require early and on-site detection of infections. The most common cause of infections in early-onset sepsis is Escherichia coli... Sepsis in young infants can lead to high mortality and morbidity, and its nonspecific signs require early and on-site detection of infections. The most common cause of infections in early-onset sepsis is Escherichia coli, particularly in premature and low-birth-weight infants. Here, the authors developed a rapid method based on loop-mediated isothermal amplification (LAMP) assay for detecting E. coli in newborn blood samples. The results showed detection of E. coli with a limit of detection (LOD) of 70 CFU/mL, confirming the assay’s reliability in distinguishing positive and negative cases compared to PCR-based detection. This LAMP assay uses 10 µL of blood and takes less than 1 h. A total of 66 blood samples from young infants were used to validate the LAMP assay, which demonstrated excellent sensitivity and specificity. A rapid and easy LAMP assay was successfully validated with young infants’ blood samples, demonstrating excellent potential for on-site detection of E. coli.

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Subacute Sclerosing Panencephalitis Mimicking Posterior Reversible Encephalopathy Syndrome.

Garg N, Gupta J, Gupta A … +4 more , Kabra U, Choudhary R, Sehra RN, Meena K

Indian J Pediatr · 2026 Jun · PMID 41961236 · Publisher ↗

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Neuroregression in Childhood: A Red Flag for Inborn Errors of Metabolism.

Kabra M

Indian J Pediatr · 2026 May · PMID 41961235 · Publisher ↗

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Expanding the Phenotypic Spectrum of INTS11-Related Neurodevelopmental Disorder.

Malmurugan YK, Manokaran RK

Indian J Pediatr · 2026 Jun · PMID 41961234 · Publisher ↗

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Morel Lavallée Lesion Following Excessive Physiotherapy for Ankle Arthritis in a Child with Juvenile Idiopathic Arthritis: Authors' Reply.

Mohan SL, Kaur P, Chandola S … +2 more , Bagri N, Jana M

Indian J Pediatr · 2026 Jun · PMID 41961233 · Publisher ↗

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A Rare Co-occurrence: Down Syndrome with Waardenburg Syndrome.

Nair SB, S R PN

Indian J Pediatr · 2026 Jun · PMID 41961232 · Publisher ↗

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Central Venous Catheter-Related Thrombosis in Critically Ill Children: Diagnostic Characteristics, Therapeutic Approaches, and Preliminary Outcomes.

Van Mai D, Le TPV, Nguyen PD … +1 more , Dao ATT

Indian J Pediatr · 2026 May · PMID 41944983 · Publisher ↗

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Hypertension: Evaluation and Management.

Mishra K

Indian J Pediatr · 2026 May · PMID 41944982 · Publisher ↗

Hypertension in children is increasing over the years, prevalence being 4% worldwide with peak at adolescence. While secondary causes predominate, essential hypertension is not uncommon, especially after 5–6 y of age, as... Hypertension in children is increasing over the years, prevalence being 4% worldwide with peak at adolescence. While secondary causes predominate, essential hypertension is not uncommon, especially after 5–6 y of age, associated with overweight or family history. Among secondary causes, renal parenchymal and renovascular etiologies are most common. As per the Clinical Practice Guidelines, 2017, of American Academy of Pediatrics, hypertension is defined as blood pressure above the 95th percentile for age, gender and height of the child, being classified as Stage 1 up to 12 mm above 95th percentile, and Stage 2 beyond this limit. It is recommended to begin screening of asymptomatic children for hypertension after three years of age, advocating lifestyle modifications when blood pressure is abnormal. Persistence of elevated blood pressure or Stage 1 hypertension for 6-12 mo requires confirmation by ambulatory blood pressure monitoring (ABPM) and evaluation, followed by pharmacological treatment. In secondary hypertension, antihypertensives are to be started at the outset, along with evaluation. ABPM is strongly recommended for monitoring in secondary hypertension to identify masked hypertension and absence of nocturnal dipping, both of which are significant prognostic markers of cardiovascular morbidity. While first-line anti-hypertensives include calcium channel blockers, angiotensin-converting-enzyme inhibitors (ACE-I), angiotensin receptor blockers (ARB), and thiazide diuretics, specific management and targeted antihypertensives may be required for the underlying cause in secondary hypertension. For acute severe hypertension intravenous agents such as sodium nitroprusside or labetalol are preferred, keeping a short-term goal of 95th centile of blood pressure, with an initial controlled reduction.

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