Searches / Journal Of The Formosan Medical Association = Taiwan Yi Zhi[JOURNAL]

Journal Of The Formosan Medical Association = Taiwan Yi Zhi[JOURNAL]

Sun 200 papers

Prevalence, risk factors, and management of adult asthma in Taipei, Taiwan: A global asthma network study.

Tsai JC, Yeh KW, Yan DC … +7 more , Ou LS, Wu CY, Lin LL, Huang SJ, Yao TC, Huang JL, Su KW

J Formos Med Assoc · 2026 May · PMID 42135139 · Publisher ↗

BACKGROUND: Adult asthma is a growing global health burden, with limited data from the Asian population. This study investigated the prevalence, management, and associated factors of adult asthma in Taipei, using the sta... BACKGROUND: Adult asthma is a growing global health burden, with limited data from the Asian population. This study investigated the prevalence, management, and associated factors of adult asthma in Taipei, using the standardized Global Asthma Network Phase I methodology. METHODS: A cross-sectional survey in 2017 collected data from 9690 adults randomly selected from the 12 districts of Taipei City. We assessed adults with physician-diagnosed asthma regarding their medication, healthcare, and work impact by gender and asthma severity. Logistic regression examined demographic, clinical, lifestyle, and dietary factors associated with physician-diagnosed asthma. RESULTS: The prevalence of physician-diagnosed asthma was 5.4%. 1.9% reported an asthma attack in the past 12 months. Females had higher rates of physician-diagnosed asthma and greater healthcare use than males. Among those with recent asthma attacks, short-acting β2 agonists were the most frequently reported relievers (49.2%), whereas controller therapies, including inhaled corticosteroid-long-acting β2 agonist (21.3%), inhaled corticosteroids (13.7%), and leukotriene receptor antagonists (12.6%), were underused and mostly taken intermittently. Logistic regression indicated asthma was positively associated with female gender, allergic rhinitis, atopic dermatitis, and frequent potato or cereal intake, but inversely associated with regular fruit intake. Asthma imposed a significant socioeconomic burden, with 2.5% of adults reporting leaving their jobs due to breathing difficulties. CONCLUSIONS: Adult asthma prevalence in Taipei is increasing and associated with allergic comorbidities and lifestyle factors. The underuse of controller therapies and disease's socioeconomic impact highlight the need for tailored interventions and longitudinal studies.

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Re-evaluation of the clinical meaningfulness of the Diagnostic Criteria for Psychosomatic Research-Revised alexithymia threshold in the Taiwanese population.

Huang WC, Chiu YT, Liao SC … +1 more , Huang WL

J Formos Med Assoc · 2026 May · PMID 42135138 · Publisher ↗

OBJECTIVE: This study aimed to re-evaluate the clinically meaningful diagnostic threshold for alexithymia using the Diagnostic Criteria for Psychosomatic Research-Revised (DCPR-R) in Taiwan to better differentiate true p... OBJECTIVE: This study aimed to re-evaluate the clinically meaningful diagnostic threshold for alexithymia using the Diagnostic Criteria for Psychosomatic Research-Revised (DCPR-R) in Taiwan to better differentiate true psychopathology from cultural norms. METHODS: A total of 502 participants (277 clinical, 225 community) were included. Data collection included demographic information and self-report questionnaires assessing emotional disturbances, somatization-related features, and quality of life (QOL). Prevalence and clinical burden were examined across varying cut-offs (meeting 3-5 criteria). Multiple regression models were used to evaluate the clinical utility and discriminative contribution of individual criteria. RESULTS: The conventional threshold (3 of 6 criteria) yielded a prevalence of 48.8% and failed to clearly differentiate clinical characteristics between alexithymic and non-alexithymic groups. Raising the cut-off to five criteria reduced prevalence to 10.2% and identified individuals with more severe depression, fewer behaviors related to health anxiety, and poorer overall, psychological, and social QOL. Item-level analyses indicated that criteria reflecting externally oriented thinking lacked discriminative value, whereas deficits in affect awareness and emotional regulation were robust predictors of clinical severity. CONCLUSION: A stricter diagnostic threshold (5 criteria) for DCPR-R alexithymia is more appropriate in the Taiwanese population, improving the identification of clinically meaningful alexithymia characterized by emotional disturbances, somatization tendencies, and poorer QOL. Emphasizing affect regulation deficits rather than externally oriented thinking enhances the construct's clinical specificity and utility in Eastern populations.

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Response to comment on "Comparative efficacy and choice of lipid-lowering drugs for cardiovascular and kidney outcomes in patients with chronic kidney disease: A systematic review and network meta-analysis".

Lin YC, Lai TS, Tu YK

J Formos Med Assoc · 2026 May · PMID 42135137 · Publisher ↗

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Comment on "Association between intraoperative pulse pressure variation and early postoperative nausea and vomiting in major abdominal surgery: A retrospective study".

Lu CW, Chang KC

J Formos Med Assoc · 2026 May · PMID 42135136 · Publisher ↗

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Response to comment on "Effectiveness of educational reinstruction on patient satisfaction and inhaler technique in Japanese patients with stable chronic obstructive pulmonary disease: A prospective, open-label, randomized controlled trial".

Sato T

J Formos Med Assoc · 2026 May · PMID 42135135 · Publisher ↗

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Response to: Beyond PTH and renal phosphate: Unraveling the mechanistic puzzle of bone protection by Vitamin D plus calcium in TDF-treated CHB patients.

Atthakitmongkol T, Tanwandee T

J Formos Med Assoc · 2026 May · PMID 42135134 · Publisher ↗

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Comment on "Fluid intake impact on heart failure: Systematic review and meta-analysis with trial sequential analysis".

Singh PS, Singh A, Sinha AP

J Formos Med Assoc · 2026 May · PMID 42120278 · Publisher ↗

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Considering the unmeasured impact of 5-fluorouracil dose intensity in the interpretation of optimal initial relative dose intensity of modified FOLFIRINOX.

Wu P, Zhong Y

J Formos Med Assoc · 2026 May · PMID 42115117 · Publisher ↗

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Response to the letter regarding "Cost-utility evaluation of mammography screening program in Taiwan based on real-world data accounting for false positives".

Lin CN, Wang JD, Ku LE

J Formos Med Assoc · 2026 May · PMID 42115116 · Publisher ↗

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Period effects as a potential confounder in radiotherapy dose escalation studies for locally advanced rectal cancer.

Wu P, Zhong Y

J Formos Med Assoc · 2026 May · PMID 42108151 · Publisher ↗

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Antibiotic susceptibility testing and the non-inferiority margin: key considerations when interpreting vonoprazan-amoxicillin dual therapy trials.

Fei L, Zhang Q

J Formos Med Assoc · 2026 May · PMID 42108150 · Publisher ↗

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Distinct gut microbiota signatures and predicted lipid metabolism pathways in Taiwanese patients with acute versus chronic coronary syndromes.

Wang WT, Lee CY, Hsieh YC … +11 more , Huang PH, Hsu PF, Leu HB, Lu TM, Wang YP, Wang CT, Chiou SH, Huang SS, Luo JC, Hou MC, Wu TC

J Formos Med Assoc · 2026 May · PMID 42108149 · Publisher ↗

BACKGROUND: The gut microbiota plays a pivotal role in host lipid metabolism and cardiovascular health. However, comparative profiling of microbial composition and predicted metabolic functions between acute coronary syn... BACKGROUND: The gut microbiota plays a pivotal role in host lipid metabolism and cardiovascular health. However, comparative profiling of microbial composition and predicted metabolic functions between acute coronary syndrome (ACS) and chronic coronary artery disease (CAD) remains limited, especially in Asian populations. METHODS: This study employed a cross-sectional microbiome analysis of prospectively enrolled patients, including 20 ACS and 22 CAD patients whose paired stool and serum samples were collected. Fecal bacterial DNA was analyzed using 16S rRNA gene sequencing. Microbial diversity and taxonomic composition were assessed using QIIME2-based pipelines. Functional predictions were performed via PICRUSt2, Tax4Fun, and BugBase, with KEGG and Clusters of Orthologous Groups (COG) annotations. Correlations with serum lipid parameters were also evaluated. RESULTS: Distinct microbial signatures were observed between the ACS and CAD groups. In ACS, Bacteroides plebeius, Tyzzerella, and Sutterella were enriched, whereas Parasutterella and Actinobacteriota were more abundant in CAD. Several taxa were correlated with serum triglyceride, LDL, and HDL levels. Although most lipid metabolism-related pathways were comparable between the groups, nominal differences were noted in linoleic acid metabolism and the biosynthesis of unsaturated fatty acids (p < 0.05; all q > 0.05). BugBase analysis revealed a significantly greater abundance of potentially pathogenic bacteria in ACS patients (q = 0.027). The NSTI scores (mean ± SD = 0.073 ± 0.03) supported the reliability of the functional predictions. CONCLUSIONS: Patients with ACS and CAD demonstrated distinct gut microbiota profiles, with ACS showing enrichment of pro-inflammatory and potentially pathogenic taxa. Although the predicted lipid metabolic functions are largely similar, subtle pathway differences and phenotypic traits suggest that a potential microbiota-lipid axis is associated with cardiovascular disease severity. These findings warrant further investigation in larger cohorts.

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Reply to the comment on "High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C".

Chen YC, Tseng KC, Yu ML

J Formos Med Assoc · 2026 May · PMID 42108148 · Publisher ↗

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Sleep and interleukin 6 as modifiers of cognitive stimulation therapy response in schizophrenia.

Wang Y, Li X, Feng J … +1 more , Shen W

J Formos Med Assoc · 2026 May · PMID 42108147 · Publisher ↗

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Comment on "Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer".

Wu Y, Wei L

J Formos Med Assoc · 2026 May · PMID 42106270 · Publisher ↗

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Comment on "Discriminative ability of left atrial strain in heart failure with mildly reduced ejection fraction".

Xu ZY, Qi Z

J Formos Med Assoc · 2026 May · PMID 42106269 · Publisher ↗

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Comment on "Vitamin D and calcium prevent bone loss in vitamin D-deficient chronic hepatitis B patients treated with tenofovir disoproxil fumarate: A randomized controlled trial".

Gao A, Hu Y

J Formos Med Assoc · 2026 May · PMID 42106268 · Publisher ↗

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Reply on "Interaction of ALDH2 and ALDH1A single-nucleotide polymorphisms with alcohol consumption and impact on osteoporosis risk".

Yii CY, Huang JY, Yong SB … +1 more , Cheng-Chung Wei J

J Formos Med Assoc · 2026 May · PMID 42106267 · Publisher ↗

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Response to comment on "Association between anticholinergic drug use and hepatic encephalopathy risk among patients with cirrhosis".

Shih HN, Wu CH, Lee YW … +1 more , Chang CC

J Formos Med Assoc · 2026 May · PMID 42106266 · Publisher ↗

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Overlooked explanatory pathways and overstated conclusions in the VA-14 vs. S-14 non-inferiority trial.

Yang C, Wu J, Zhou C

J Formos Med Assoc · 2026 May · PMID 42106265 · Publisher ↗

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