Anais Brasileiros De Dermatologia[JOURNAL]

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Zoonotic sporotrichosis in pediatric patients: analysis of 30 cases at a referral center in São Paulo, Brazil.

Souza BCM, Valinoto GCJ, Veasey JV

An Bras Dermatol · 2026 · PMID 42030584 · Full text

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Predictors of early high-level response to bimekizumab in patients with moderate-to-severe plaque psoriasis: a real-world cohort study.

Engin B, Demir Y, Yildirim G … +4 more , Diken FZ, Yildiz B, Kutlubay Z, Serdaroglu S

An Bras Dermatol · 2026 · PMID 42025118 · Full text

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Epiplakin expression in non-melanoma skin cancer: associations with epithelial-mesenchymal transition markers and tumor invasion.

Fındık DG, Türelik Ö

An Bras Dermatol · 2026 · PMID 42025117 · Full text

BACKGROUND/OBJECTIVES: Epiplakin is a member of the plakin family of proteins involved in cytoskeletal organization, yet its role in skin cancers remains poorly understood. This study aimed to evaluate epiplakin expressi... BACKGROUND/OBJECTIVES: Epiplakin is a member of the plakin family of proteins involved in cytoskeletal organization, yet its role in skin cancers remains poorly understood. This study aimed to evaluate epiplakin expression in cutaneous skin lesions and to investigate its association with epithelial-mesenchymal transition markers and tumor progression. METHODS: The authors retrospectively analyzed skin specimens from squamous cell carcinomas, basal cell carcinomas, and benign intradermal nevi collected between 2021 and 2025. Histopathological features were assessed, and immunohistochemical analysis of Epiplakin, E-cadherin, and N-cadherin was performed. Epiplakin expression was quantified and correlated with cadherin levels and Breslow thickness. Plakin family protein-protein interaction networks were analyzed using KEGG pathway and GO functional enrichment. RESULTS: Protein-protein interaction network analysis demonstrated that plakin family members are associated with multiple cancer-related pathways, with a prominent enrichment in regulating cell proliferation. Epiplakin expression was significantly higher in squamous cell carcinomas (389.94 ± 70.56) compared with basal cell carcinomas (70.39 ± 15.32) and intradermal nevi, while basal cell carcinomas showed a significant decrease compared with normal skin (p < 0.05). In non-melanoma skin cancers, epiplakin expression demonstrated a strong positive correlation with E-cadherin (r = 0.565, p < 0.001) and a weak positive correlation with N-cadherin (r = 0.329, p < 0.05). No significant correlation was observed with Breslow thickness (p > 0.05). STUDY LIMITATIONS: Retrospective design and the absence of high-grade squamous cell carcinoma cases in the study population. CONCLUSIONS: This is the first study to assess epiplakin expression among epithelial cutaneous cancers. Epiplakin appears to be associated with epithelial-mesenchymal transition and early tumor progression, and its differential expression pattern may provide diagnostic utility.

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Eruptive sebaceous hyperplasia induced by oral tacrolimus with good therapeutic response to systemic isotretinoin: a case report.

Silva GPD, Ferreira FR, Moya FG

An Bras Dermatol · 2026 · PMID 42025116 · Full text

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Topical tapinarof (benvitimod) for papulopustular rosacea: two cases.

Wang L, Li S, Lin J … +2 more , Wu Q, Ju Q

An Bras Dermatol · 2026 · PMID 42025115 · Full text

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Poliosis as a clinical sign of melanoma arising on a congenital nevus.

Matínez García S, Arroyo Córdoba A, López Riquelme I

An Bras Dermatol · 2026 · PMID 42025114 · Full text

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Histopathological evaluation of facial melasma treated with oral tranexamic acid alone and in combination with ketotifen.

Cruz ACL, Cassiano DP, Miot HA … +8 more , Espósito ACC, Hassum K, de Brito MB, E Silva Enokihara MMS, Lima Constantino MCC, Bottura HR, de Almeida JS, Bagatin E

An Bras Dermatol · 2026 · PMID 42025113 · Full text

BACKGROUND: Tranexamic Acid (TA) has demonstrated effectiveness on melasma treatment, and Ketotifen (KET) may inhibit mast cell-mediated melanogenesis. The histologic basis of their depigmenting effects remains unclear.... BACKGROUND: Tranexamic Acid (TA) has demonstrated effectiveness on melasma treatment, and Ketotifen (KET) may inhibit mast cell-mediated melanogenesis. The histologic basis of their depigmenting effects remains unclear. OBJECTIVES: To evaluate histopathological changes from TA with KET over a 3-month treatment. METHODS: In this randomized, double-blind trial, 50 women with facial melasma were assigned to KET 1 mg plus TA 250 mg (TA/KET group) or TA 250 mg (TA group), every 12 h for 3-months, with broad-spectrum sunscreen. Skin biopsies were performed at baseline and day-90. Primary outcome was epidermal melanin density reduction; secondary outcomes included stratum corneum compaction, solar elastosis, basement membrane disruptions, and counts of mast cells, melanocytes (including pendulum melanocytes), and upper dermal VEGF density. RESULTS: Groups were comparable at baseline. Both showed reduced epidermal melanin without intergroup difference, with unchanged VEGF expression, mast cell and melanocyte count, and stratum corneum parameters. The TA/KET-group presented an increase in epidermal thickness, reduction in solar elastosis, pendulum melanocytes counting, and basal membrane disruptions. STUDY LIMITATIONS: The short treatment and follow-up may have limited detection of histologic progression. Toluidine blue, while effective in detecting abundant mast cell populations, may lack sensitivity for precise quantification. PAS staining of the basement membrane may occasionally produce artifactual discontinuities, even when the membrane is structurally intact. Ketotifen was not tested alone. CONCLUSION: Both interventions led to epidermal melanin reduction. The combination TA/KET induced greater dermal and epidermal remodeling changes that surpassed those with TA alone, showing features associated with photoaging reversal and skin homeostasis restoration.

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Dupilumab-resistant Netherton syndrome associated with a novel SPINK5 variant: c.575A>G (p.Asn192Ser).

Zhou Q, Wang C, Jiang Q … +3 more , Jiang R, Qu Z, Chen L

An Bras Dermatol · 2026 · PMID 42025112 · Full text

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Differential melanoma outcomes in men and women: longitudinal findings from a ten-year study.

Sampaio NM, Cruz FWM, Castro SMO … +6 more , Oliveira ACR, Martins PR, Cardoso FDS, da Silva SG, Duprat Neto JP, Muglia Amancio A

An Bras Dermatol · 2026 · PMID 42025111 · Full text

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Primary periocular basal cell carcinoma: recurrence, risk factors and follow-up.

Bezerra RG, Dos Santos Souza DC, Eduardo Correntes J … +2 more , Sousa RLF, Schellini SA

An Bras Dermatol · 2026 · PMID 42013678 · Full text

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Atypical fibroxanthoma in sun-protected sites: two cases in the inguinal region and thigh.

Kim HS, Choi WG, Oh SH … +3 more , Lee SK, Lee UH, Kim MS

An Bras Dermatol · 2026 · PMID 42001554 · Full text

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Cutaneous leishmaniasis caused by Leishmania infantum arising within a psoriatic plaque: a case report.

Bourgeois P

An Bras Dermatol · 2026 · PMID 42000338 · Full text

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A multicenter study by the Brazilian Society of Dermatology on a new standard patch test series.

Bonamigo RR, Rocha VB, Reis VMSD … +17 more , Rodrigues DF, Lazzarini R, Pires MC, Hikawa RS, Kiszewski AE, França AFEDC, Heck R, Scherrer MAR, Samorano LP, Cordeiro ICM, Duarte IA, Hafner MFS, Pires RMG, Eller LS, Rodrigues JB, Bumaguin DB, Hahnstadt RL

An Bras Dermatol · 2026 · PMID 41903428 · Full text

BACKGROUND: The prevalence of allergic contact dermatitis (ACD) differs across various populations, and the sensitization rate can change constantly as new products are introduced to the market. The current Brazilian sta... BACKGROUND: The prevalence of allergic contact dermatitis (ACD) differs across various populations, and the sensitization rate can change constantly as new products are introduced to the market. The current Brazilian standard series of patch tests has been used for over two decades. Therefore, the development of a new Brazilian standard series is important to ensure that contact tests remain a reliable diagnostic tool. METHODS: A Brazilian multicenter, cross-sectional, prospective study was conducted using a modified series of patch tests between 2023 and 2025. The factors under study were the substances used in the contact tests, and the outcomes were the frequencies of positivity and relevance. Demographic and clinical variables of the participants, who had contact dermatitis without a defined etiology prior to the tests, were evaluated. The required sample size was defined as 523 patients, estimating the prevalence of positivity with a 1.8% confidence interval. Wald's test was considered a 95% confidence level and a 1% expected prevalence of positivity. RESULTS: A total of 567 participants were included, 77.3% female, with a mean age of 53.3 years, and most belonged to phototypes II, III, and IV. Cleaning services were the most frequent occupational activity, and 43.3% of patients had a personal history of atopy. The overall reactivity of the tests was 69.3%, with 70.2% relevance. Nickel sulfate was the most frequently reactive allergen (28.9%), and 29 substances reached at least 1% positivity. STUDY LIMITATIONS: Lack of representatives from all regions of Brazil and absence of prospective follow-up. CONCLUSION: The authors propose a new Brazilian standard series of patch tests, with 40 substances, considering the 29 that achieved 1% positivity and another 11 with clinical importance and supported by current literature as emerging and current allergens.

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