Acta Informatica Medica[JOURNAL]
Sun
200 papers
The Quality of Health Services Provided to Patients Undergoing Myocardial Perfusion Imaging by a Nuclear Medicine Department.
Iliadis C, Kourkouta L, Bountas D … +4 more , Tsaloglidou A, Koukourikos K, Frantzana A, Doumas A
Acta Inform Med · 2022 Mar · PMID 35800908 · Full text
BACKGROUND: Nuclear medicine procedures can be delivered in different healthcare settings, such as outpatient centers, medical clinics, mobile units, and hospitals. The process of providing care to the patient can be mod...
BACKGROUND: Nuclear medicine procedures can be delivered in different healthcare settings, such as outpatient centers, medical clinics, mobile units, and hospitals. The process of providing care to the patient can be modified according to the provision arrangement; however, the basic level of quality of service should be maintained, and continuous improvement should be pursued. OBJECTIVE: The objective of this research study is to investigate the quality of health services provided to patients undergoing myocardial perfusion imaging by a nuclear medicine department. METHODS: The data collected through the questionnaires were saved in an Excel sheet, and then, they were analyzed by using the SPSS 24 statistical software platform. Firstly, the demographic data of the sample are presented by using a frequency table. In terms of the main questions, for those of them that were not answered in the Likert scale, frequency charts were used to present their results. RESULTS: From the analysis, it emerged that 75% (n=75) of the sample was composed of male patients, and 25% (n=25) was composed of female patients. Regarding the age distribution of the patients of the survey, it was observed that 39% (n=39) were between 45 and 64 years old, 35% (n=35) were over 65 years old, and 26% (n=26) were between 18 and 44 years old. Moreover, it was observed that 17% (n=17) of the sample were Secondary School graduates, 17% (n=17) were Technological Education graduates, 16% (n=16) were Primary School graduates, 16% (n=16) were High School graduates, and 14% (n=14) were University graduates. CONCLUSION: The levels of satisfaction ranged were moderate regarding access to the clinics, and were lower regarding the time required between the date of making the appointment and the date of performing the examination.
Features of International Publications in Vietnamese Radiological Societies after The Enactment of 37/2018/QĐ-TTg.
Duc NM, Khoa MT, Thong PM
Acta Inform Med · 2022 Mar · PMID 35800907 · Full text
BACKGROUND: In Vietnam, after the enactment of 37/2018/QĐ-TTg, a distinct shift could be observed in the international publications by radiological societies. OBJCTIVE: This study examined trends in the international pub...
BACKGROUND: In Vietnam, after the enactment of 37/2018/QĐ-TTg, a distinct shift could be observed in the international publications by radiological societies. OBJCTIVE: This study examined trends in the international publications achieved by Vietnamese radiological societies following the enactment of 37/2018/QĐ-TTg. METHODS: This retrospective study evaluated data that are freely accessible and available online and, therefore, did not require institutional review board approval. We assessed the publication characteristics of the members of four Vietnamese radiological societies: Vietnamese Society of Radiology and Nuclear Medicine (VSRNM, = 67); Radiological Society of Ho Chi Minh City (RSHCM, = 25); Vietnamese Society of Ultrasound in Medicine (VSUM, = 29); and Vietnamese Society of Interventional Radiology (VSIR, n = 18), following the enactment of 37/2018/QĐ-TTg. RESULTS: Following the enactment of 37/2018/QĐ-TTg, we observed that total publications, number of first authors, number of last authors, number of articles indexed in Web of Science, and number of articles indexed in Scopus were significantly higher for the VSRNM and VSIR than for the RSHCM and VSUM. All publication parameters were significantly higher men, individuals who secured professorship, PhD and Master's degree holders, public hospital employees, those in the radiological field, and those in the north and south regions, compared with the values for women, individuals without professorships, Specialist II and I degree holders, private hospital employees, those in the nuclear medicine field, and those in the middle region, respectively. CONCLUSION: The enactment of 37/2018/QĐ-TTg triggered a new trend in international publication among the members of four Vietnamese radiological societies. However, strong discrepancies remain in total publications, number of first authors, number of last authors, number of articles indexed in Web of Science, and number of articles indexed in Scopus among the members of the four main Vietnamese radiological societies.
Impact of Reduced Acquisition Time on Bone Single-photon Emission Computed Tomography Images in Oncology Patients.
Salkica N, Begic A, Zubovic S … +5 more , Ceric S, Basic A, Sehic A, Julardzija F, Tinjak E
Acta Inform Med · 2022 Mar · PMID 35800906 · Full text
BACKGROUND: The use of resolution recovery (RR) in bone and myocardial perfusion imaging is becoming increasingly popular in nuclear medicine departments. RR produces reconstructed images that show improved spatial resol...
BACKGROUND: The use of resolution recovery (RR) in bone and myocardial perfusion imaging is becoming increasingly popular in nuclear medicine departments. RR produces reconstructed images that show improved spatial resolution and signal-to-noise ratio compared with conventional single-photon emission computed tomography (SPECT) images. OBJECTIVE: To evaluate the impact of the ordered subset expectation maximization (OSEM) RR modality on preserving noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) for short SPECT acquisition. METHODS: This prospective study was conducted on 80 patients. Full SPECT acquisition was performed as a standardized protocol, while reduced acquisition was achieved with the Poisson resampling method. Noise, SNR, and CNR were measured for different reconstruction parameters for the same image levels. The impact of surface area and body mass index was also measured for the same reconstruction parameters. RESULTS: The results show significantly higher SNR and CNR for the Evolution for Bone protocol compared to the other two reconstruction protocols for full and reduced SPECT acquisition. With the shortening of the SPECT acquisition, an increase in the value of noise was recorded. SNR and CNR decreased with the reduction in SPECT acquisition. CONCLUSION: The Evolution for Bone protocol for all three analyzed acquisition protocols had the lowest noise values. The highest SNR and CNR were recorded in the Evolution for Bone protocol for the three acquisition protocols and SPECT acquisition time can be reduced from 20 to 10 min for bone SPECT.
The Diagnostic Value of Combined 24-h BP and ECG Holter Monitoring in Detection of Cardiac Arrhythmias in Patients with Arterial Hypertension.
Naser N, Pepic E, Avdic S
Acta Inform Med · 2022 Mar · PMID 35800905 · Full text
BACKGROUND: Arrhythmias are common problems in hypertensive patients. The presence and complexity of both supraventricular and ventricular arrhythmias may influence morbidity, mortality, as well as the quality of life of...
BACKGROUND: Arrhythmias are common problems in hypertensive patients. The presence and complexity of both supraventricular and ventricular arrhythmias may influence morbidity, mortality, as well as the quality of life of patients. OBJECTIVE: The aim of this study was to assess the diagnostic value of combined 24h BP and ECG Holter monitoring in detection of cardiac arrhythmias in patients with arterial hypertension. METHODS: We analyzed the simultaneous records of combined 24h BP and ECG Holter monitoring for 356 adult patients with diagnosed arterial hypertension in the period from January 2017 until January 2021 year. The cardiac arrhythmias were classified in three main groups as following: a) Supraventricular arrhythmias; b) Ventricular arrhythmias; c) Bradyarrhythmia's. Standard transthoracic echocardiograms were performed in order to evaluate signs of hypertensive or structural heart disease with focus on left ventricle hypertrophy and LV function. RESULTS: Patients had a mean age of 64 ± 11years, 62% male. Average clinic BP was 153.4+18/87.5+14 mmHg. More than 46% of patients displayed a very high-risk profile. In all enrolled patients, cardiac arrhythmia was detected in 302 (84%) patients. The total number of patients with supraventricular arrhythmias was 153 (50,7%). Ventricular arrhythmias were detected in 98 (32,5%) patients. Bradyarrhythmia's were detected in 51 (16,9%) patients. Elevated resting heart rate in sinus rhythm was detected in 87 (31,6%) of 275 patients with sinus rhythm. CONCLUSION: Most arrhythmias are related to longstanding arterial hypertension. Effective treatment of arterial hypertension plays important role in preventing structural and functional cardiac abnormalities which will contribute to the reduction of cardiac arrhythmias in hypertensive patients.
Dental Fear and Anxiety in 9-12 Years Old Children in Clinical Setting in Bosnia and Herzegovina: Normative Values and Types of Informant.
Bajric E, Huseinbegovic A, Zukanovic A … +5 more , Markovic N, Arslanagic A, Selimovic-Dragas M, Katana E, Kobaslija S
Acta Inform Med · 2022 Mar · PMID 35800904 · Full text
BACKGROUND: The most commonly used diagnostic tests for evaluation of the dental fear and anxiety (DFA) presence in children were psychometric scales, where interpretation in determining and using of their cut-off scores...
BACKGROUND: The most commonly used diagnostic tests for evaluation of the dental fear and anxiety (DFA) presence in children were psychometric scales, where interpretation in determining and using of their cut-off scores sometimes was not completely exact. Also, several studies have been conducted where the results were conflicting in terms of who better assessed the DFA presence - the children, their parents, or dentists. OBJECTIVE: To determine the normative values in the child and parental versions of the Modified version of the CFSS-DS scale (CFSS-DS-mod scale) and to compare the ways in which children, their parents, and the dentist assessed the DFA presence in the dental office. METHODS: Survey sample consisted of 200 children aged from 9 to 12 years, whose DFA presence was determined by the CFSS-DS-mod scale. Child parents answered to their version of this scale, and the dentist observed the child behavior in the dental office during the treatment using Venham Anxiety and Behaviour Rating Scales. RESULTS: Parental version of the CFSS-DS-mod scale found to be reliable (Cronbach alpha = 0.955) and valid (67.87% of variance explained) instrument for assessment of the DFA presence in children. Two cut-off scores were determined in a child (37 and 43), as well as in a parental version of CFSS-DS-mod scale (36 and 44), respectively. Dentists assessed the DFA presence in child patients most accurately. CONCLUSION: The normative values of psychometric instruments should be considered prior to their use. The borderline area of DFA presence should also be taken into account in the future studies. Children could underestimate DFA existence by themselves while interviewing.
The Management Growth Plate Injury in Animal Studies with Stem Cells Technique: Systematic Review.
Sananta P, Isnansyah Y, Rosandi RD … +1 more , Sugiarto MA
Acta Inform Med · 2022 Mar · PMID 35800903 · Full text
BACKGROUND: Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate t...
BACKGROUND: Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate this problem. There are various types and techniques which can be implemented. OBJECTIVE: This systematic review aims to review the most common techniques used in the experimental animal study about the application of stem cells to treat growth plate injury. METHODS: This study was conducted according to PRISMA guidelines. The following strategy was used. The terms used on the search engine were "stem cell growth plate injury" in PubMed database. A bibliometric evaluation was done on all the search results. RESULTS: The initial PubMed search yielded 74 results, but 5 articles were eliminated because they could not be accessed. From the remaining 69 articles, 50 were excluded after abstract and full-text review. Further, 7 articles were eliminated because they did not meet the inclusion criteria. Most studies are experimental animal studies, and there is no human trial regarding this matter. CONCLUSION: There are still a few studies evaluating the application of stem cell in treating growth plate injuries, but the present results are generally satisfactory. Hopefully, clinical trials could be conducted in the near future.
On Occasion of 30th Anniversary of the Biomedical Informatics Journal "Acta Informatica Medica" - 1993-2022.
Masic I
Acta Inform Med · 2022 Mar · PMID 35800902 · Full text
Acta Informatica Medica journal (www.actainformmed.org), as Biomedical Informatics journal, during past 30 years of existing played important role in distribution of knowledge and experience within this scientific field,...
Acta Informatica Medica journal (www.actainformmed.org), as Biomedical Informatics journal, during past 30 years of existing played important role in distribution of knowledge and experience within this scientific field, by publishing contributions of the biomedical experts from worlwide and spreading of Biomedical informatics knowledge and experiences in scientific and academic community. Acta Informatica Medica journal has been founded in the year 1993 by Izet Masic and Zoran Ridjanovic, as official journal of Bosnian-Herzegovinan Society of Medical Informatics (BHSMI). In the year 2019 Acta Informatica Medica has been accepted as official journal of the European Federation for Medical Informatics (www.efmi.org), besides 3 other journals: International Journal of Medical Informatics, Methods of Information in Medicine and European Journal of Biomedical Informatics. Journal Acta Informatica Medica is abstracted and indexed in 30 on-line data bases, including Pubmed, Pubmed Central, Scopus, Embase, Hinari, etc. The journal follows the Guidelines and recommendations of ICJME, COPE, EASE, WAME, etc. as well as the recommendations of the "Sarajevo Declaration on Integrity and Visibility of Scholarly Journals", accepted by 17 Editors of biomedical journals at "SWEP 2018" Conference held in Sarajevo and printed in the countries in South-Eastern Europe. The journal supports presentations at conferences held in Bosnia and Herzegovina. The abstract papers presented at "The Mediterranean Seminar on Science Writing, Editing and Publishing" - "SWEP 2016", "SWEP 2018"; "SWEP 2020" and "SWEP 2021", also found its place in the journal, by which we met our goal of promoting science and scientific publication at the area of Bosnia and Herzegovina and other countries in the region. Acta Informatica Medica has been ranked: Highest Impact Factor for 2011-2022 was 1.496 and Lowest Impact Factor for 2011-2022 was 0.59. During the year 2021 in Acta Informatica Medica journal was published 46 papers. From total amount published papers, 67,39% was original papers, where it was more published original papers in the journal than in the year 2020. Acta Informatica Medica has value of important metrics (last updated on November 16, 2021): Impact Score - 1.50, h-Index - 20, Rank - 15980, SJR - 0.267.
Mixed Methodology of Scientific Research in Healthcare.
Smajic E, Avdic D, Pasic A … +2 more , Prcic A, Stancic M
Acta Inform Med · 2022 Mar · PMID 35800901 · Full text
BACKGROUND: Scientific research is usually classified as quantitative or qualitative. However, methodologists are increasingly emphasizing the integration of qualitative and quantitative data as the center of mixed metho...
BACKGROUND: Scientific research is usually classified as quantitative or qualitative. However, methodologists are increasingly emphasizing the integration of qualitative and quantitative data as the center of mixed methods (mix methodologies). Mixed research method implies the use of different research methods, ie. quantitative and qualitative methods in one study. OBJECTIVE: The aim of this review paper is to present the purpose of using a mixed methodology in health research. METHODS: The relevant articles were searched from online data sources including PubMed and Google Scholar. RESULTS: This approach to the use of mixed methods creates opportunities for a deeper study of various problems. The purpose of using mixed research methods is to obtain valid answers to research questions, however the researcher may still have different reasons or purposes for which he wants to strengthen the research study and its conclusions by applying mixed methods. The use of mixed scientific methodology is widely used in the field of health outcomes and should not be limited to a closed list of possible methodological options. CONCLUSION: Recently, there has been an increase in the number of scientific studies in healthcare that use mixed research methods. The advantage of applying this scientific method is that through the triangulation of data obtained by different (quantitative / qualitative) approaches, we get a deeper and more complete picture of the phenomenon in health care that we observe.
The Most Influential Scientists in the Development of Medical Informatics (31): Rory O'Moore (- 2022).
Masic I
Acta Inform Med · 2022 Jun · PMID 35774843 · Full text
Abstract loading — click title to view on PubMed.
Surgical Site Infection Management following Spinal Instrumentation Surgery: Implant Removal vs. Implant Retention: an Updated Systematical Review.
Yudistira A, Asmiragani S, Imran AW … +1 more , Sugiarto MA
Acta Inform Med · 2022 Jun · PMID 35774842 · Full text
BACKGROUND: The number of lumbar spine surgery increased in recent years. Spinal instrumentation surgery was an integral component in the treatment of spinal pathologies, which can cause surgical site infection (SSI). Su...
BACKGROUND: The number of lumbar spine surgery increased in recent years. Spinal instrumentation surgery was an integral component in the treatment of spinal pathologies, which can cause surgical site infection (SSI). Surgical site infections (SSIs) are the leading cause of mortality and morbidity after spinal instrumentation surgery. The management of SSI was implant retention and removal is still unclear. OBJECTIVE: The objective of this literature is to systematically review the implant removal and retention method for SSI management after spinal instrumentation surgery. METHODS: We searched in PubMed and ScienceDirect for cohort and randomized control trial studies in English, published between 2002 and 2022, which had data on patients with spinal instrumentation surgery. The underlying disease, comorbidities, common bacteria, type of infection, the onset of infection, implant removal, and retention percentage and recommendation were analyzed. Bias analysis using Newcastle-Ottawa Quality Assessment. RESULTS: We included 15 studies with a total sample were 2.584 with an average of age 15 to 66 years old. The most common organism detected were S. Aureus, MRSA, and S. Epidermis. The most common surgical procedure indications were degenerative followed by scoliosis. Implant removal and retention rate were 0-100% and 0-90,32% respectively. Implant removal is more frequently used in patients after spinal instrumentation surgery than the implant retention method. CONCLUSION: Implant retention can be performed in case of SSI is < 3 months after surgery. Implant removal is recommended if the incidence of SSI is > 3 months. Empirical antibiotics therapy is necessary to reduce the possibility of implant removal after debridement. Further studies on the effect of implant removal and retention in patients on infection recurrence, pain, and quality of life of patients are needed.
The Effectiveness of Sperm Preparation Using Density Mini-Gradient and Single-Layer Centrifugation for Oligospermia Samples.
Hoa NT, Son NK, Hoa TP … +4 more , Giang MT, Dung LN, Duc NM, Ha NM
Acta Inform Med · 2022 Jun · PMID 35774841 · Full text
BACKGROUND: Sperm preparation is an important step during assisted reproduction, and different assisted reproductive techniques have different sperm quality requirements. For intrauterine insemination (IUI), the total mo...
BACKGROUND: Sperm preparation is an important step during assisted reproduction, and different assisted reproductive techniques have different sperm quality requirements. For intrauterine insemination (IUI), the total motile sperm count is a predictor of a patient's fertility. OBJECTIVE: The aim of this study was to compare the sperm recovery rate and DNA fragmentation index (DFI) outcomes following density mini-gradient and single-layer centrifugation in preparation for intrauterine insemination (IUI). METHODS: A total of 30 semen samples with concentrations under 15 million cells/ml were obtained, and each sample was divided into 3 aliquots, with each aliquot subjected to 1 of 3 separation methods: mini-gradient, single-layer using a 90% density layer (single 90-layer), and single-layer using a 45% density layer (single 45-layer). Total sperm motility and sperm recovery rates were compared before and after preparation using each method. RESULTS: The sperm concentration obtained using single 45-layer was higher than the other groups (p<0.05), but sperm motility was higher using the mini-gradient and single 90-layer methods higher than the single 45-layer method (p<0.05). The recovered sperm motility rates for the mini-gradient, single 90-layer, and single 45-layer methods were 57.6% ± 20.6%, 62.8% ± 18.5%, and 78.7% ± 12.4%, respectively, indicating a better outcome for the single 45-layer method than for the other methods. CONCLUSION: All of these methods can be applied to sperm preparation for IUI, and the optimal method can be selected based on initial sperm quality to collect sperm with good motility and DNA integrity to achieve a satisfactory pregnancy rate.
Reconstruction of Dorsal Hand Burn Scars Using Microdissected Tailoring of the Free Anterolateral Thigh Flap.
Son TT, Hoang NV, Dung PV … +3 more , Tan PV, Duy TT, Duc NM
Acta Inform Med · 2022 Jun · PMID 35774840 · Full text
BACKGROUND: Currently, large defects of the dorsum and finger of the hand pose a great challenge to plastic surgeons. The most difficult problem is finding a suitable material that has a large area and a thin, reliable b...
BACKGROUND: Currently, large defects of the dorsum and finger of the hand pose a great challenge to plastic surgeons. The most difficult problem is finding a suitable material that has a large area and a thin, reliable blood supply and can be tailored into many small flaps to cover the fingers. CASE SERIES: We present the cases of two patients admitted to our hospital with scars on the dorsal side of the hand after gas burns. The defects after scar release were reconstructed by microdissected tailoring of the free anterolateral thigh flap. Complete survival was achieved for all flaps, including the small flaps tailored for finger defects. The function and aesthetics of the hands significantly improved. The patients were satisfied after the pain, itching, and burning symptoms of the scar were relieved. CONCLUSION: Microdissected tailoring of the free anterolateral thigh flap is an ideal method for addressing hand defects. The microdissected tailoring technique allows the surgeon to construct a thin flap with a reliable blood supply from the perforator.
Iraqi Medical Student's Perceptions of Learning Environment Following Surgical Curriculum Change.
Khalaf H, Almothafar B, Alhalabi N
Acta Inform Med · 2022 Jun · PMID 35774839 · Full text
BACKGROUND: There are three undergraduate medical school curricula types - 'traditional', 'integrated', and 'problem-based learning' (PBL). Traditional curricula involve teaching basic medical science in the early years...
BACKGROUND: There are three undergraduate medical school curricula types - 'traditional', 'integrated', and 'problem-based learning' (PBL). Traditional curricula involve teaching basic medical science in the early years in an atomistic and often didactic way, predominantly through lectures. In later years, students move on to learning clinical skills and applying their medical knowledge in clinical settings. Meanwhile, the philosophy of integrated curricula is that students learn best by understanding medical science in relation to whole systems and by linking knowledge with practice. Integrated curricula take a more holistic approach and bring together elements of medical science rather than teaching them in isolation. OBJECTIVE: The study aimed to measure and compare perceptions of the learning environment between two cohorts of medical students at a medical school in Iraq. The intention was to explore differences in perceptions between those following a traditional surgical curriculum and those following an innovative, integrated curriculum and thereby add to the body of evidence looking at the impact of the two surgical curriculum models on the learning environment. METHODS: The Dundee Ready Educational Environment Measure (DREEM) was used to measure students' perceptions of their learning environment. The unpaired t-test was used to compare the mean scores of two cohorts of medical students. RESULTS: The global mean score for the students following the integrated curriculum was higher than the global mean scores for the group studying the traditional curriculum. This difference is statistically significant. The mean scores for the integrated curriculum students are higher than those of the traditional curriculum students for all sub-sets of the measure. The difference is statistically significant for one sub-set, 'Students' Perceptions of Learning,' and the difference is close to being statistically significant for the 'Students' Perception of Teachers' sub-set. CONCLUSION: The results reflect those from other international studies and add to the body of evidence that suggests that innovative, integrated curricula are a critical factor in promoting a more positive learning environment than that generated within a traditional curriculum model.
Treatment of Complications Due to Fuchs Heterochromic Iridocyclitis (FHI) - a Case Report.
Adilovic M, Kalabic M, Cabric A … +1 more , Becirovic D
Acta Inform Med · 2022 Jun · PMID 35774838 · Full text
BACKGROUND: Fuchs heterochromic iridocyclitis is a chronic, unilateral iridocyclitis characterized by iris heterochromia. The gradual progression of the disease leads to the development of cataracts, glaucoma, and, occas...
BACKGROUND: Fuchs heterochromic iridocyclitis is a chronic, unilateral iridocyclitis characterized by iris heterochromia. The gradual progression of the disease leads to the development of cataracts, glaucoma, and, occasionally, vitreous infiltration. The trigger for inflammation of the iris and ciliary body is still unknown. There are several as yet unconfirmed theories about the mechanism of occurrence, including Toxoplasma gondii infection, immune dysfunction, infiltration of sensitized lymphocytes, and chronic herpes virus infection. OBJECTIVE: The aim of this article is to present a case of Fuchs heterochromic iridocyclitis with complications in form of glaucoma and dense cataract in a female patient during a standard ophthalmologic exam in our clinic. The next aim is to show a proper algorithm of treatment in form of carbonic anhydrase inhibitors antiglaucoma medication, cataract surgery with implantation of the intraocular lens, yag laser capsulothomy. CASE REPORT: A 55-year-old patient reports to our clinic for an examination. She was informed 7 years ago by her ophthalmologist that her lack of vision in the right eye is irreparable. Ophthalmological examination as well as a positive TORCH test (elevation of IgG for toxoplasma gondii) lead to a diagnosis of Fuchs heterochromic iridocyclitis with complications of glaucoma and dense cataract. Antiglaucoma drops are prescribed, PHACO surgery is performed on the right eye with implantation of the intraocular lens, and yag laser capsulotomy in the follow ups. There was a significant improvement of the visual acuity from light sensation with uncertain projection of the same on the right eye, to 0,5-0,6 Snellen scale. We also educated the patient of her disease as well as the importance of her treatment and follow up consultations. CONCLUSION: Due to the insidious nature of this condition, along with a mild chronic course, most patients with FHI are not aware of the subtle changes that occur in their eyes. One of the most serious complications of FHI is secondary glaucoma, which can cause permanent vision loss in patients. The main cause of poor vision in patients with FHI is caused by cataract formation, with a prevalence of 23% to 90.7%. We placed special emphasis on educating the patient about her condition and the long-term and importance of regular check-ups to prevent possible recurrent or new complications.
The Management Growth Plate Injury in Animal Studies with Stem Cells Technique: Systematic Review.
Sananta P, Isnansyah Y, Rosandi RD … +1 more , Sugiarto MA
Acta Inform Med · 2022 Jun · PMID 35774837 · Full text
BACKGROUND: Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate t...
BACKGROUND: Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate this problem. There are various types and techniques which can be implemented. OBJECTIVE: This systematic review aims to review the most common techniques used in the experimental animal study about the application of stem cells to treat growth plate injury. METHODS: This study was conducted according to PRISMA guidelines. The following strategy was used. The terms used on the search engine were "stem cell growth plate injury" in PubMed database. A bibliometric evaluation was done on all the search results. RESULTS: The initial PubMed search yielded 74 results, but 5 articles were eliminated because they could not be accessed. From the remaining 69 articles, 50 were excluded after abstract and full-text review. Further, 7 articles were eliminated because they did not meet the inclusion criteria. Most studies are experimental animal studies, and there is no human trial regarding this matter. CONCLUSION: There are still a few studies evaluating the application of stem cell in treating growth plate injuries, but the present results are generally satisfactory. Hopefully, clinical trials could be conducted in the near future.
Acta Informatica Medica Journal Review in 2021.
Masic I
Acta Inform Med · 2022 Jun · PMID 35774836 · Full text
Acta Informatica Medica journal (www.actainformmed.org), as Biomedical Informatics journal, during past 30 years of existing played important role in distribution of knowledge and experience within this scientific field,...
Acta Informatica Medica journal (www.actainformmed.org), as Biomedical Informatics journal, during past 30 years of existing played important role in distribution of knowledge and experience within this scientific field, by publishing contributions of the biomedical experts from worlwide and spreading of Biomedical informatics knowledge and experiences in scientific and academic community. Acta Informatica Medica journal has been founded in the year 1993 as official journal of Bosnian-Herzegovinan Society of Medical Informatics (BHSMI). In the year 2019 Acta Informatica Medica has been accepted as official journal of the European Federation for Medical Informatics (www.efmi.org), besides 3 other journals: International Journal of Medical Informatics, Methods of Information in Medicine and European Journal of Biomedical Informatics. Journal Acta Informatica Medica is abstracted and indexed in 30 on-line data bases, including Pubmed, Pubmed Central, Scopus, Embase, Hinari, etc. The journal follows the Guidelines and recommendations of ICJME, COPE, EASE, WAME, etc. as well as the recommendations of the "Sarajevo Declaration on Integrity and Visibility of Scholarly Journals", accepted by 17 Editors of biomedical journals at "SWEP 2018" Conference held in Sarajevo and printed in the countries in South-Eastern Europe. SCImago rank for 2021 announced the bibliometric list of the journals deposited in SCOPUS indexed database. On the list are 16 journals which are published in Bosnia and Herzegovina, and between them are 7 within biomedical sciences. Three highest are Bosnian Journal of Basic Medical Sciences - H-Index is 29, Medical Archives - H-Index is 26 and Acta Informatica Medica - H-Index is 24, etc. Acta Informatica Medical journal has Impact Score, Overall Ranking, h-index, SJR, Rating, Publisher updated on May 27, 2022: Impact Score - 1.87; h-Index - 24; Rank -12749 and SJR - 0.372.
Molecular Docking Approach of Bryophyllum Pinnatum Compounds as Atherosclerosis Therapy By Targeting Adenosine Monophosphate-Activated Protein Kinase and Inducible Nitric Oxide Synthase.
Yuniwati Y, Syaban MFR, Anoraga SG … +1 more , Sabila FL
Acta Inform Med · 2022 Jun · PMID 35774835 · Full text
BACKGROUND: is a herbal medicine from Indonesia which has an anti-inflammatory effect. Adenosine monophosphate-activated protein kinase (AMPK) and inducible nitric oxide synthase (iNOS) play a function in thickening and...
BACKGROUND: is a herbal medicine from Indonesia which has an anti-inflammatory effect. Adenosine monophosphate-activated protein kinase (AMPK) and inducible nitric oxide synthase (iNOS) play a function in thickening and inflammation in atherosclerosis disease. OBJECTIVE: This research aims conducted to know the potential of as a therapy for atherosclerosis by targeting AMPK and iNOS. METHODS: We employed a molecular docking technique to interact active compounds of with AMPK and iNOS, which were retrieved on the protein databank. Molecular docking analysis utilizing tools such as Pyrx 9.5, Pymol, and Discovery Studio, to support the interaction between the compound and protein. Molecular Dynamic (MD) simulation also performed using CABS-FLEX 2.0 server to know the stability interaction. RESULTS: Bryophillin B was an active compound that possesses significant binding to AMPK and iNOS. It had same binding pocket as native ligand, and Bryophyllin B has a stronger interaction with AMPK. Based on the RMSF, the interaction biding complex Bryophyllin B with AMPK and iNOS were stable. CONCLUSION: Bryophillin B was predicted to have potential therapy for atherosclerosis disease.
The Regulation of Hypoxia Inducible Factor (HIF)1α Expression by Quercetin: an In Silico Study.
Wahyuningsih SPA, Dewi FRP, Hsan ASY … +5 more , Lee LM, Lim V, Aun LIL, Ling TC, Marviella ST
Acta Inform Med · 2022 Jun · PMID 35774834 · Full text
BACKGROUND: Cancer disease is a growing health problem in developing and developed countries. Hypoxia-inducible factor-1a (HIF1α) is a transcription factor responsible for expressing several proteins involved in angiogen...
BACKGROUND: Cancer disease is a growing health problem in developing and developed countries. Hypoxia-inducible factor-1a (HIF1α) is a transcription factor responsible for expressing several proteins involved in angiogenesis. Quercetin can suppress HIF1α expression due to the inhibition of protein synthesis. However, to date, the study exploring the potential of quercetin in repressing HIF1α through its degradation mechanism has never been done. An in silico study is needed as a preliminary study to understand the mechanism underlining this possibility. OBJECTIVE: This study aimed to investigate the potential of quercetin in regulating HIF1α expression through the ubiquitin degradation pathway by in silico study. METHODS: This study was performed by in silico analysis, including biological activity prediction, 3D protein structure collection, protein-ligand and protein-protein docking, and the visualization of the docking results. RESULTS: The probability activity (Pa) score of quercetin as an HIF1α expression inhibitor was 0.969. In the absence of quercetin, the center-weighted score of HIF1α - pVHL, HIF1α - FIH, and HIF1α - PHD2 was -699.4 kJ/mol, -846.0 kJ/mol, and -650.5 kJ/mol, respectively. In the presence of quercetin, the weighted score of HIF1α - pVHL, HIF1α - FIH, and HIF1α - PHD2 was reduced to -728.1 kJ/mol, -854.2 kJ/mol, and -650.5 kJ/mol, respectively. CONCLUSION: Quercetin could directly promote HIF1α and pVHL interaction, thus increasing the degradation of HIF1α by ubiquitin-dependent pathway.
Comparative Analysis of SARS-CoV-2 Detection Kits.
Mulahuseinovic N, Salihefendic L, Durgut S … +2 more , Kandic E, Konjhodzic R
Acta Inform Med · 2022 Jun · PMID 35774833 · Full text
BACKGROUND: SARS-CoV-2 is a coronavirus that causes a respiratory disease, COVID-19. For COVID-19 testing, real-time PCR is considered gold standard and therefore many commercial SARS-Cov-2 detection kits are available....
BACKGROUND: SARS-CoV-2 is a coronavirus that causes a respiratory disease, COVID-19. For COVID-19 testing, real-time PCR is considered gold standard and therefore many commercial SARS-Cov-2 detection kits are available. OBJECTIVE: The aim of the study is to determine diagnostic values of 10 different commercially available SARS-CoV-2 detection kits, based on their Ct value. METHODS: For this study thirty clinical nasopharyngeal samples were collected in ALEA Genetic Center. Twenty four of them were positive, while six were negative and used as a negative control. Positive samples were selected based on the day when first symptoms appeared. RNA was extracted using the same extraction method for all samples. For amplification and comparison of detection kits, the same RT- PCR instrument was used. RESULTS: Accuracy, sensitivity, specificity and Cohen's kappa coefficient were estimated to evaluate diagnostic values of the tested kits. This study showed that all kits showed 100% specificity. Accuracy, sensitivity and kappa coefficient varied among examined assays. Based on clinical features, LabGun COVID-19 Assay by LabGenomics proved to be the most sensitive, the most accurate and most specific. Therefore this assay was used as a reference kit. CONCLUSION: If things from practice are taken into account, accuracy and reliability of the tested commercial kits can vary compared to those obtained in this study where results were based on ideal functioning of the kits. When choosing the convenient commercial SARS-CoV-2 detection kit using RT-PCR method, many parameters need to be considered.
The Most Influential Scientists in the Development of Biomedicine (31) Francis Roger France (1941-2021).
Masic I
Acta Inform Med · 2021 Dec · PMID 35197666 · Full text
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