Journal Of Oleo Science[JOURNAL]
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200 papers
Toward Self-Propelled Microrobots: A Systems Chemistry that Induces Non-Linear Phenomena of Oil Droplets in Surfactant Solution.
Banno T
J Oleo Sci · 2025 · PMID 39880632 · Publisher ↗
Biological activities observed in living systems occur as the output of which nanometer-, submicrometer-, and micrometer-sized structures and tissues non-linearly and dynamically behave through chemical reaction networks...
Biological activities observed in living systems occur as the output of which nanometer-, submicrometer-, and micrometer-sized structures and tissues non-linearly and dynamically behave through chemical reaction networks, including the generation of various molecules and their assembly and disassembly. To understand the essence of the dynamic behavior in living systems, simpler artificial objects that exhibit cell-like non-linear phenomena have been recently constructed. However, most objects exhibiting cell-like dynamics have been found through trial-and-error experiments, and there are no strategies for designing them as molecular systems. This review describes how cell-like dynamics of oil droplets in surfactant solution, such as self-propelled motion, chemotaxis, division, and deformation, are induced by combining molecular properties of system components toward self-propelled microrobots.
Effects of Commonly Used Vegetable Oils on Skin Barrier Function and Staphylococcus aureus Biofilm.
Chen YS, Chien AS, Li CC … +2 more , Lin CC, Wu RJ
J Oleo Sci · 2025 · PMID 39756997 · Publisher ↗
Adding of vegetable oils to skincare products or the use of plant oils for oil care is a current trend. Therefore, the safety and functionality of vegetable oils are of great concern to consumers and cosmetics manufactur...
Adding of vegetable oils to skincare products or the use of plant oils for oil care is a current trend. Therefore, the safety and functionality of vegetable oils are of great concern to consumers and cosmetics manufacturers. This study focused on three types of vegetable oils: sunflower oil (SO), andiroba oil (AO) and hydrogenated olive oil (HOO). We conducted a comprehensive evaluation of the oils, which encompassed their ability to protect mouse skin keratinocytes (XB-2) and mouse fibroblasts (NIH 3T3) from damage caused by the surfactant sodium lauryl sulfate (SLS), their influence on the levels of filaggrin and collagen, their potential to aid in wound healing, and their effectiveness in anti-Staphylococcus aureus biofilm formation. The results showed that SO, AO and HOO at a concentration of 1.5 × 10 % (v/v) have the ability to defend against SLS-induced cell damage, increase wound healing ability and the filaggrin and collagen content to XB-2 or NIH 3T3 cells. SO, AO and HOO at a concentration of 3.75 × 10 % also have the anti-biofilm ability. Among the oils, AO can inhibit S. aureus biofilm composed of either polysaccharides or proteins. Therefore, the tested vegetable oils and can be applied to the cosmetics field as ingredients to repair damaged skin and preserve skin barrier stability.
Effects of Different Cooking Processes on the Phytochemical Profile and Mineral Content of Garlic (Allium sativum L.).
Binici Hİ
J Oleo Sci · 2025 · PMID 39756996 · Publisher ↗
In this study, the effects of different cooking processes on the phytochemical profile and mineral content of garlic (Allium sativum L.) were determined. Different cooking processes had a significant effect on the moistu...
In this study, the effects of different cooking processes on the phytochemical profile and mineral content of garlic (Allium sativum L.) were determined. Different cooking processes had a significant effect on the moisture, pH, water-soluble solids, L*, a*, b*, C* and °h values. The phenolic profile was generally better preserved in the steamed garlic samples than in the control samples. The mineral content of garlic prepared different cooking processes, with the exception of copper and magnesium, was found to be relatively high. As a result, the phenolic acid and mineral contents of garlic samples prepared with different cooking processes were better preserved and were closest to those of the control samples. In addition, to preserve the valuable compounds in garlic, adding them to dishes after the cooking process is completed is recommended.
In vitro Antioxidant and Antibacterial Activities, Bioactive Compounds, Organic Acids, Sugars, Micro- and Macro-elements of Aquilaria agallocha Root Organic Extracts.
Akbulut HF
J Oleo Sci · 2025 · PMID 39756995 · Publisher ↗
Aquilaria agallocha is an economically valuable plant facing endangerment, sought after globally for its production of agarwood. A. agallocha tree possesses medicinal and aromatic properties in its fruits, branches, leav...
Aquilaria agallocha is an economically valuable plant facing endangerment, sought after globally for its production of agarwood. A. agallocha tree possesses medicinal and aromatic properties in its fruits, branches, leaves, wood, and roots, which are being studied for their effective compounds and their potential bioactive effects on human health. This study aimed to uncover the phytochemical properties and biological activities of A. agallocha roots, which possess medicinal and aromatic characteristics. The phenolic, organic acid, and sugar profiles of A. agallocha roots were determined using HPLC-DAD, while mineral distributions were analyzed via ICP-AES. In vitro antioxidant capacity was assessed using the 2,2-diphenyl- 1-picrylhydrazyl (DPPH) assay. Furthermore, the antibacterial effects of methanol extracts of A. agalocha roots against S. aureus, S. carnosus, B. cereus, L. monocytogenes, E. coli, L. innocua, K. pneumoniae, and E. faecalis were estimated with disc diffusion and MIC methods. The amount of total phenolic and in vitro DPPH radical scavenging capacity of A. agalocha roots were determined as 7.529 mg GAE/g and 18.83 µmol TE/g, respectively. Eight phenolic components were detected in the extracts of A. agalocha roots. The most dominant among these phenolic compounds detected was tannic acid, which was followed by 4-hydrobenzoic acid and oleuropein, respectively. In the aqueous extracts of A. agalocha roots, four organic acids were identified, including citric, tartaric, malic and succinic acid, and succinic acid was the most dominant organic acid. Only fructose sugar was detected in the water extracts of A. agalocha roots. The extracts of A. agalocha roots had a strong antibacterial effect against all gram-positive pathogens except for S. carnosus, but did not have any effect against gram-negative bacteria.
A Straightforward Synthesis of Pinocembrin.
Iwai K, Nishiwaki N
J Oleo Sci · 2025 · PMID 39756994 · Publisher ↗
A simple synthetic method for pinocembrin from cinnamic acid and 1,3,5-trihydroxybenzene was provided. This method can be performed in one-pot two steps reaction using inexpensive chemical reagents, whereas conventional...
A simple synthetic method for pinocembrin from cinnamic acid and 1,3,5-trihydroxybenzene was provided. This method can be performed in one-pot two steps reaction using inexpensive chemical reagents, whereas conventional methods need multiple steps from somewhat expensive starting reagents. The experimental procedure is facilitated, that is, to a DMF solution of cinnamoyl chloride generated in situ, a solution of 1,3,5-trihydroxybenzene and AlCl in DCE/PhNO was added, and the resultant mixture was heated to afford pinocembrin. This method does not require protection of phenolic hydroxy groups.
Antibiofilm and Antiquorum Sensing Potential of Pheretima posthum.
Hussain M, Naseem S, Latif AA … +10 more , Ali A, Aftab MN, Ali S, Ara C, Liaqat I, Ali NM, Afzaal M, Khalid A, Yang GJ, Liaqat I
J Oleo Sci · 2025 · PMID 39756993 · Publisher ↗
Antibiotic resistance is a world wide problem mainly in developing countries. In this work, coelomic fluid (PCF) and paste (PBP) of Pheretima posthuma was assessed for its potential as antibiofilm and anti-quorum sensing...
Antibiotic resistance is a world wide problem mainly in developing countries. In this work, coelomic fluid (PCF) and paste (PBP) of Pheretima posthuma was assessed for its potential as antibiofilm and anti-quorum sensing (QS) agent against pathogenic bacterial biofilms. PCF and PBP were extracted and biofilm formation time kinetics was examined using crystal violet staining method by utilizing four bacterial isolates in bispecies biofilm (06 combinations; MH5-MH10) and multi species biofilms (05 combinations; MH11-MH15). QS study was performed by determining pyocyanin formation time kinetics using 03 P. aeruginosa strains at various time periods (0, 24, 48, 72, 96 and 120 hours). Following next, anti- QS effect was analyzed by measuring pyocyanin concentrations. Results showed that among bispecies bacterial biofilms, MH5-MH7 combinations showed significantly higher biofilm (p < 0.05) after 72 hours while other three (MH8-MH10) produced maximum biofilm after 48 to 72 hours. Likewise, for multispecies biofilms, maximum biofilm was noted after 48-72 hours. QS analysis revealed that PA1 strain synthesized highly significant (p < 0.001) pyocyanin (20 µg/mL) after 96 hours compared to PA2 and PA3 strains, which formed significant pyocyanin (18 µg/mL) after 72 hours. Also, 100-150 µg/mL of both PCF and PBP exhibited a significant (p < 0.05) reduction in biofilm while 200 µg/mL concentration showed highest QS against all selected strains. To our knowledge, this is the first assessment of its kind on the potential application of earthworm PCF and PBP for its antibiofilm and anti-QS potential. The study recommends precise chemistry of bioactive agents and their probable mechanism(s) of actions for the observed interference. Also, new pharmaceutical drugs synthesized using bioactive agents from PCF and PCB may surely have the potential to manage different infection problems caused by bacterial biofilms.
Mixed Micellization and Density Functional Theory (DFT) Studies on the Molecular Interactions between Gemini and Nonionic Surfactants.
Azum N, Rub MA, Chani MTS … +3 more , Alzahrani KA, Asad M, Kamal T
J Oleo Sci · 2025 · PMID 39756992 · Publisher ↗
In the present study, the mixed micellization behavior of gemini surfactant-1, 5-bis (N-hexadecyl- N, N-dimethylammonium) pentane dibromide (G5) with non-ionic surfactant triton X-100 (TX-100) was investigated in the mic...
In the present study, the mixed micellization behavior of gemini surfactant-1, 5-bis (N-hexadecyl- N, N-dimethylammonium) pentane dibromide (G5) with non-ionic surfactant triton X-100 (TX-100) was investigated in the micellar phase by utilizing the conductometric technique. The deviation of ideal critical micelle concentration (cmc*) from experimental critical micelle concentration (cmc) has been estimated using well-known Clint's theory of mixed micelles. The regular solution approximation was used to determine the interaction parameter (β) and found to be negative. The negative values of β at all mole fractions confirm an attractive interaction between two mixed components. The activity coefficients and excess Gibbs free energy of mixed micelles have been calculated by using different approximations, like Rubingh, Lange and Motomura. Counterion binding (g) computed from the post and premicellar slopes of specific conductance vs. concentration graph. Overall, in most of cases, in presence of TX-100, the counterion binding of gemini surfactant was found to be less in magnitude. The molecular interaction was also investigated by the density function theory (DFT). A polarizable continuum model (PCM) was used (with water as a solvent) to optimize the single surfactants and their mixture. The computational process was carried out by the B3LYP method and the 6-31G basis set.
Effect of Cholic Acid Salt and Its Mixed Micelles on the Morphology of Giant Unilamellar Vesicles (GUV).
Miyake M, Tanaka R, Oda M … +7 more , Morigaki A, Sekine Y, Sorada A, Akamatsu M, Arakawa K, Sakai K, Sakai H
J Oleo Sci · 2025 · PMID 39756991 · Publisher ↗
Bile salts, present in the gastrointestinal tract as biosurfactants, play a crucial role in emulsifying and solubilizing fat-soluble nutrients and drugs, thereby facilitating their absorption. However, the cellular perme...
Bile salts, present in the gastrointestinal tract as biosurfactants, play a crucial role in emulsifying and solubilizing fat-soluble nutrients and drugs, thereby facilitating their absorption. However, the cellular permeation of bile acid-mixed micelles solubilized with lipophilic substances remains inadequately explored. To comprehend the cell permeation behavior of bile salts and their mixed micelles, giant unilamellar vesicles (GUVs) were employed as a cell-mimetic system, prepared with dioleylphosphatidylcholine (DOPC). Confocal laser scanning microscopy, utilizing fluorescent dyes doped in the lipid membrane and solubilized substances, was employed to observe morphological changes in GUVs subsequent to the application of sodium cholate (NaC) alone and NaC-mixed micelles solubilized with lipophilic components. In the case of NaC alone, below the critical micelle concentration (CMC), the monomer interacts with the lipid membrane of the GUV, inducing endocytic morphological changes that result in the formation of small vesicles containing the bulk liquid inside the GUV. Conversely, when both monomers and micelles interacted with the lipid membrane beyond the CMC, lipid aggregates such as buds and threads protruded outward from the GUV. Contrastingly, upon application of three types of NaC mixed micelles-NaC-P solubilized with Palmitoyloleoylphosphocholine (POPC), NaC-P-F solubilized with oleic acid (OA) and monoolein (MO), and NaC-P-P solubilized with perylene, a liposoluble dye-to the GUV, the lipid membranes formed aggregates or vesicles and migrated into the interior of the GUV. In the case of NaC-P and NaC-P-P, the coexistence of drawn lipid aggregates and solubilized substances was scarcely observed. In contrast, for NaC-P-F, the coexistence of solubilized substances was observed in both lipid aggregates and small vesicles that migrated into the GUV. It is suggested that the partitioning of the solubilized substance from the mixed micelles adsorbed on the GUV to the lipid bilayer is implicated in the permeation of the solubilized substance through the cell membrane.
The Role of Microwave and Oven Roasting on Oil Contents, Bioactive Properties, Phenolic Components, Fatty Acids and Mineral Contents of Grape (Vitis spp.) Seeds.
Ahmed IAM, AlJuhaimi F, Özcan MM … +2 more , Uslu N, Albakry Z
J Oleo Sci · 2025 · PMID 39756990 · Publisher ↗
In this study, the role of roasting on the total phenol, antioxidant capacity, phenolic constituents and fatty acid profile of the grape seeds was investigated. Total phenolic and flavonoid quantities of the grape seeds...
In this study, the role of roasting on the total phenol, antioxidant capacity, phenolic constituents and fatty acid profile of the grape seeds was investigated. Total phenolic and flavonoid quantities of the grape seeds roasted in microwave (MW) and conventional oven (CO) systems were recorded between 673.57 (control) and 713.57 (MW) to 7121.67 (MW) and 7791.67 mg/100 g (CO), respectively. Antioxidant activities of the grape seeds varied between 6.57 (MW) and 7.24 mmol/kg (control). Catechin and rutin quantities of the grape seeds were recorded to be between 435.30 (CO) and 581.57 (control) to 94.94 (CO) and 110.53 mg/100 g (MW), respectively. While gallic acid amounts of the seed samples are established between 21.06 (control) and 101.79 (MW), quercetin values of the grape seeds were assigned to be between 56.59 (control) and 77.81 mg/100 g (CO). In addition, p-coumaric acid and resveratrol quantities of the grape seeds were recorded between 15.43 (control) and 22.98 (CO) to 12.50 (CO) and 29.57 mg/100 g (MW), respectively. The main fatty acids in oil samples were linoleic, oleic, palmitic and stearic acids in decreasing order. Linoleic and oleic acid values of the oils provided from grape seeds were recorded to be between 72.75 (control) and 73.33% (MW) to 14.79 (CO) and 14.87% (MW), respectively. It was observed that the element results related to the grape seed differed based on the roasting type when compared to the control. The most abundant elements in the grape seed were K, P, Mg, S, Na, Fe, Ca, Zn, and K and P amounts of the grape seeds were reported to be between 6706.93 (MW) and 7089.33 (control) to 2764.27 (CO) and 2927.97 mg/kg (control), respectively. It is thought that it would be beneficial to add grape seeds to foods as an ingredient by taking into account these phytochemical components as a result of the applied heat treatment.
Progress of Researches on Pharmacological Effects and Bioavailability of Tangeretin.
Wang W, Jia T, Zhang Y … +1 more , Zhou Y
J Oleo Sci · 2025 · PMID 39756989 · Publisher ↗
Tangeretin is one of the most abundant polymethoxyflavones in citrus peel and its pharmacological effects are extremely rich. However, due to its poor solubility, bitter taste and poor oral bioavailability, the oral admi...
Tangeretin is one of the most abundant polymethoxyflavones in citrus peel and its pharmacological effects are extremely rich. However, due to its poor solubility, bitter taste and poor oral bioavailability, the oral administration of tangeretin is still limited, which seriously limits its application in industrial production. The establishment of encapsulation and delivery systems to improve bioavailability is an effective method. This paper reviewed the research progress of the structure and properties, pharmacological effects and main methods to improve bioavailability of tangeretin, including emulsion delivery, lipid encapsulation, microencapsulation and other delivery and utilization research and application. The article aims to provide theoretical basis for the high-value application of tangeretin in functional food and pharmaceutical industry.
Preparation and Structural Properties of Gel Coating Films Containing Lipophilized Nanocarbon Particles Functionalized with Thixotropic Chains.
Hasunuma Y, Sakamoto S, Yamagishi Y … +1 more , Fujimori A
J Oleo Sci · 2025 · PMID 39756988 · Publisher ↗
Gel coating films comprising nanodiamonds organo-modified with 12-hydroxystearic (12-OHC ) and stearic acids were prepared and characterized. Because molecules with 12-OHC groups can convert solvents into thixotropic gel...
Gel coating films comprising nanodiamonds organo-modified with 12-hydroxystearic (12-OHC ) and stearic acids were prepared and characterized. Because molecules with 12-OHC groups can convert solvents into thixotropic gels, Gemini-type diamide derivatives with two 12-OHC chains were also introduced as thixotropic additives into the gel coating films. Although the 12-OHC -modified nanodiamonds did not lead to solvent gelation on their own, they displayed an affinity for the thixotropic additive molecules. The 12-OHC -modified nanodiamonds were localized near the surface of the nanofibers formed by the Gemini-type diamide derivative in the solvent, and the thixotropic properties of the supramolecular gel were confirmed. Nanoparticle aggregation and nanofiber crystallinity were found to be suppressed by the effect of 12-OHC modification in the gel coating films, making them suitable for cosmetic coating applications.
Health Benefits of Dietary Docosahexaenoic Acid- and Eicosapentaenoic Acid-enriched Glycerophospholipids from Marine Sources.
Hosomi R
J Oleo Sci · 2025 · PMID 39756987 · Publisher ↗
Omega-3 long-chain polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are widely used as supplements and pharmaceuticals because of their beneficial effects on human hea...
Omega-3 long-chain polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are widely used as supplements and pharmaceuticals because of their beneficial effects on human health. Triacylglycerols (TAG) and glycerophospholipids (GPL) comprise the primary chemical structures of DHA/EPA in marine sources. Furthermore, DHA/EPA-enriched glycerophospholipids (DHA/EPA-GPL) and lysoglycerophospholipids (DHA/EPA-LysoGPL) consumed through food and supplements are more effective than TAG in promoting health, which may be attributed to a specific underlying mechanism. However, the specific effects of DHA/EPA bound to GPL structure have been still unclear. The aim of this review is to clarify the significance of the binding of DHA/EPA to GPL in promoting the health benefits of DHA/EPA-GPL and DHA/EPA-LysoGPL. Additionally, the potential use of fishery by-products as sources of DHA/EPA-GPL and DHA/EPA-LysoGPL has been discussed.
Friction and Corrosion Properties of Phytic Acid Ionic Liquid-water Mixtures.
Zheng D, Su T
J Oleo Sci · 2024 · PMID 39617435 · Publisher ↗
The study involved the preparation of mixtures of phytic acid ionic liquid and water, which were analyzed for their rheological, frictional, and electrochemical properties. The viscosity and friction characteristics of t...
The study involved the preparation of mixtures of phytic acid ionic liquid and water, which were analyzed for their rheological, frictional, and electrochemical properties. The viscosity and friction characteristics of the mixtures are significantly affected by the water content. Mixtures with low water content (below 30%) result in low friction and negligible wear because of the generation of a close adsorption film and high viscosity. Especially, steel tribo-pairs lubricated with mixtures containing 25% water exhibited friction coefficients lower than 0.06. However, when the water content exceeds 35%, the friction coefficient increases dramatically, and the tribo-surface suffers from severe corrosive wear due to the predominance of tribocorrosion in the frictional properties. These results were confirmed through XPS and electrochemical testing.
HPLC-DAD Profiling of Phenolic Components and Comparative Assessment of Antioxidant Potency in Opuntia robusta, Opuntia dillenii, and Opuntia ficus-indica Cladodes at Diverse Stages of Ripening.
Marhri A, Rbah Y, Allay A … +7 more , Boumediene M, Tikent A, Benmoumen A, Melhaoui R, Elamrani A, Abid M, Addi M
J Oleo Sci · 2024 · PMID 39617434 · Publisher ↗
Global distribution of prickly pear spans worldwide, with limited cladode exploitation, particularly in Mediterranean regions, excluding American continent nations. Our research reports on three species found in eastern...
Global distribution of prickly pear spans worldwide, with limited cladode exploitation, particularly in Mediterranean regions, excluding American continent nations. Our research reports on three species found in eastern Morocco, including Opuntia ficus indica and the two newly introduced species Opuntia robusta and Opuntia dillenii. The study aims to evaluate the total phenolic content, the amounts of various phenolic compounds classes, and the antioxidant activity across a spectrum of biochemical measurements including the 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP), 2,2'-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and total antioxidant capacity assay (TAC). The results showed that O. robusta exhibited the highest total phenolic content (5061.70 mg GAE/100 g) which enhances the significance of this species in terms of nutrition. Differences were also observed in different stage of cladodes maturity, demonstrating that the age factor affects the polyphenol contents. Moreover, O. robusta displays the highest amount of total phenolic compounds (11430.35 μg/g) either for flavonoids or phenolic acids. Furthermore, the oldest cladodes show more higher phenolic compounds (22998.62 μg/g) compared to the youngest one's (20438.54 μg/g). Ten phenolic compounds were identified, in which isorhamnetin represent the most abundant flavonoid (6747.85 μg/g), while the chlorogenic acid was determined as the major phenolic acid (2771.69 μg/g) followed by sinapic acid (2047.64 μg/g). The DPPH assay indicates that O. ficus-indica possessed the higher hydrophilic antioxidants able to reduction the 2,2-diphenyl-1-picrylhydrazylradical free radical. While O. robusta exhibited a greater quantity of antioxidants, which effectively reduced the Fe complex of ferric ions (TPTZ) . In contrast, old cladodes of O. robusta and O. dillenii demonstrate the higher ability to scavenge the 2,20-azinobis (3-ethylbenzthiazolin-6-sulfonic acid) or ABTS .
Nutritional and Volatile Fingerprint Characteristics of an Amazon Fruit: Ficus subapiculata.
Moura LGS, H de Almeida MM, Souza FDCDA … +5 more , Aguiar JPL, Corrêa PG, Lima CHDS, Amaral ACF, Silva JRA
J Oleo Sci · 2024 · PMID 39617433 · Publisher ↗
Ficus subapiculata is distributed throughout the Amazon region, although its potential for commercial fruit production has not yet been explored. We describe here the chemical and nutritional composition of F. subapicula...
Ficus subapiculata is distributed throughout the Amazon region, although its potential for commercial fruit production has not yet been explored. We describe here the chemical and nutritional composition of F. subapiculata fruits and some aspects of the postharvest maturation. The fruits are low in calories (69.83 kcal), have moderate carbohydrate content (15.1 g/100 g), and a high moisture content (82.15 g/100 g), with physicochemical properties and an organic acid profile that classify them as acidic. After 72 hours of observation at room temperature, fresh fruits exhibited signs of deterioration, such as color changes and weight due to senescence, making them unsuitable for consumption. Forty-five volatile organic compounds (VOCs) were identified in the fresh fruits through headspace analysis, most belonging to the terpenoid class of aromatic notes. Over 96 hours of observation, the fruits showed variations in their volatile compound profiles and a significant decrease in total VOCs content. The compounds that bound most strongly to the olfactory receptor in a docking study, such as germacrene D, also had the strongest odorcausing effects. The results suggest that the ability of aromatic notes to influence the olfactory perception of fruit is related to how well they fit and interact with the OR1G1 target protein. Finally, the chemical constituents and nutritional composition of F. subapiculata fruits were determined, and their 96 h of observation period at room temperature was evaluated. These findings provided important information for a better understanding of the nutritional potential and properties of this fruit.
The Anti-inflammatory Effect and Molecular Docking of Essential Oils Extracted from Rhizomes of Distichochlamys benenica and Distichochlamys citrea.
Tran GB, Pham TV, Turkmen M … +2 more , Nguyen NH, Do BH
J Oleo Sci · 2024 · PMID 39617432 · Publisher ↗
Distichochlamys genus, belonging to the ginger family, are native to Vietnam and there has not been many research mentioned about biological properties of this genus. In this study, essential oils were extracted from the...
Distichochlamys genus, belonging to the ginger family, are native to Vietnam and there has not been many research mentioned about biological properties of this genus. In this study, essential oils were extracted from the rhizomes of Distichochlamys benenica (DBEO) and Distichochlamys citrea (DCEO), and the components were identified using gas chromatography-mass spectrometry. Further, for the first time, the anti-inflammatory activity of these essential oils was evaluated in vitro using nitric oxide inhibitory assay and in silico via binding with the inflammatory cyclooxygenase proteins (COX-1 and COX-2). The main constituents of DBEO and DCEO, according to the results, were 1,8-cineole, (E)-citral and (Z)-citral. The nitric oxide release was inhibited by DBEO and DCEO, with IC values of 27.13±2.43 and 37.44±3.02 µg/ mL, respectively. Moreover, the COX-1 and COX-2 proteins formed strong bonds with 1,8-cineole, (E)- citral, and (Z)-citral, whose free energies roughly ranged from -54.78 to -84.08 kcal/mol. These results suggested that by inhibiting multiple inflammatory proteins, DBEO and DCEO may have a promising anti-inflammatory effect.
Effect of Dietary Oxidized Stigmasterol on the Antioxidant System in Mice.
Ohara Y, Osada K
J Oleo Sci · 2024 · PMID 39617431 · Publisher ↗
Dietary phytosterols exhibit beneficial functions, such as hypocholesterolemic action; however, oxidized phytosterols may exhibit various harmful effects that include cytotoxicity and inflammation. The effects of dietary...
Dietary phytosterols exhibit beneficial functions, such as hypocholesterolemic action; however, oxidized phytosterols may exhibit various harmful effects that include cytotoxicity and inflammation. The effects of dietary oxidized phytosterols, especially individual oxidized phytosterols, on the antioxidant system in vivo are currently unknown. Stigmasterol is a major phytosterol, and its oxidation products have been shown to be cytotoxic as they induce reactive oxygen species (ROS) generation. Therefore, we examined the toxic effects of dietary oxidized stigmasterol on the antioxidant system in mice. Mice were fed a standard diet (C group) or that plus 0.25% oxidized stigmasterol (OS group) for 14 days. Oxidized stigmasterol levels in the liver were higher in the OS group than in the C group. Dietary oxidized stigmasterol increased the levels of thiobarbituric acid-reactive substances in the liver. However, plasma alanine transaminase and aspartate transaminase activities did not differ between the two groups. The plasma ferric ion-reducing antioxidant power value and liver glutathione (GSH) levels were significantly higher in the OS group than in the C group. The enzyme activities of catalase, GSH reductase, and GSH-S-transferase in the liver cytosol were higher in the OS group than in the C group, despite the lack of change observed in their gene expression. Therefore, dietary oxidized stigmasterol may disturb the antioxidant system; however, its effects may be temporary due to the rapid action of antioxidant enzymes or GSH in response to the generation of ROS.
Therapeutic Effects of Rebamipide Nanocrystals as Carbopol Gel Formulation Containing Gum Arabic in a Hamster Model of Oral Mucositis.
Otake H, Masuda S, Kadowaki R … +5 more , Ogata F, Nakazawa Y, Yamamoto N, Kawasaki N, Nagai N
J Oleo Sci · 2024 · PMID 39617430 · Publisher ↗
Severe oral mucositis is a major cause of a low quality of life in patients; however, the therapeutic effect of traditional treatments is insufficient. Therefore, we designed a carbopol gel based on rebamipide nanocrysta...
Severe oral mucositis is a major cause of a low quality of life in patients; however, the therapeutic effect of traditional treatments is insufficient. Therefore, we designed a carbopol gel based on rebamipide nanocrystals (REB NCs) and gum arabic (GA-REB@NP), and investigated its efficacy in accelerating wound healing in a hamster model of oral mucositis. REB NCs were prepared by bead milling, and GA- REB@NP were prepared by incorporating REB NCs into a carbopol gel. The REB sizes were measured using a SALD-7100 and NanoSight LM10, and both powder X-ray diffraction and differential thermal analysis were used to analyze the crystalline form. Drug release from the gel formulations and therapeutic effects were evaluated using hamsters. The particles of milled-REB without GA were microsized, whereas the particle size of milled-REB with GA was in the range of 30-180 nm, and the crystalline form was similar to that of REB with or without bead milling. Next, we evaluated the characteristics of GA-REB@NP. The particle size of REB in GA-REB@NP was in the range of 45-200 nm, and drug release from GA-REB@NP was higher than that from the gel incorporating REB microcrystals (GA-REB@MP). In addition, REB nanoparticles were released from GA-REB@NP. Moreover, inhibitors of both clathrin- (dynasore) and caveolae-dependent endocytosis (nystatin) attenuated the enhanced REB levels in the cheek pouches of hamsters treated with GA-REB@NP. GA-REB@NP also enhanced the healing of the wound area compared with GA-REB@MP in hamsters injected with acetic acid. We prepared GA-REB@NP, which provided high REB delivery into the cheek pouch tissue via endocytosis. Additionally, we demonstrated that wound healing in acetic acid-injected hamsters was promoted by the application of GA-REB@NP.
Structural Analysis of Interfacial Films of Oil/Water Emulsions Prepared by Emulsification via Lamellar Gels.
Kuwabara H, Ogura T, Tsuchiya K … +4 more , Akamatsu M, Arakawa K, Sakai K, Sakai H
J Oleo Sci · 2024 · PMID 39617429 · Publisher ↗
An effective approach to stabilize emulsions is to increase the rigidity of oil-water (O/W) interfacial films by adsorbing molecular assemblies such as lamellar phases around the emulsion particles. In this study, we aim...
An effective approach to stabilize emulsions is to increase the rigidity of oil-water (O/W) interfacial films by adsorbing molecular assemblies such as lamellar phases around the emulsion particles. In this study, we aimed to analyze the structure of a lamellar phase adsorbed at an O/W interface and to clarify the effect of the structure and physicochemical properties of the lamellar phase on the dispersion stability of emulsions. The adsorption of the lamellar phase at the O/W interface of the emulsions was confirmed by freeze-fracture transmission electron microscopy of O/W emulsions prepared by diluting and dispersing gels formed with polyglycerol fatty acid esters, water, and cetyl isooctanoate (CIO). The structure of the lamellar phase adsorbed at the O/W interface was analyzed in detail through small-angle X-ray scattering measurement and indirect Fourier transform analysis. The lamellar phase adsorbed at the O/W interface was shown to have an interdigitated structure with low CIO content, whereas it changed to a non-interdigitated structure with increasing CIO content. Furthermore, the adsorbed lamellar phases with interdigitated structures and high rigidity provide the emulsion with higher dispersion stability.
The Effect of Roasting on Bioactive Properties, Phenolic Compounds and Fatty Acid Profiles of Pumpkin (Cucurbita spp.) Seeds.
Ahmed IAM, AlJuhaimi F, Karrar E … +2 more , Uslu N, Özcan MM
J Oleo Sci · 2024 · PMID 39617428 · Publisher ↗
In this study, the effect of roasting process on oil, antioxidant activity, total phenol, flavonoid, carotenoid and phenolic constituents and fatty acid compositions of pumpkin (Cucurbita spp.) seeds and oils was investi...
In this study, the effect of roasting process on oil, antioxidant activity, total phenol, flavonoid, carotenoid and phenolic constituents and fatty acid compositions of pumpkin (Cucurbita spp.) seeds and oils was investigated. The oil yields of "Topak" and "Sivri" pumpkin seeds were assessed to be between 47.41 (control) and 51.02% (oven) to 45.29% (control) and 48.56% (microwave), respectively. Total phenolic, total flavonoid quantities and antioxidant capacities of the "Topak" and "Sivri" pumpkin seeds roasted in the oven were higher than the bioactive compounds and antioxidant activities of pumpkin seeds roasted in the microwave. In addition, the oil, total phenol, total flavonoid quantities and antioxidant activity values of "Topak" pumpkin seeds were higher when compared to the results of "Sivri" pumpkin seeds. Gallic acid quantities of "Topak" and "Sivri" pumpkin seeds were recorded to be between 2.13 (microwave) and 8.53 mg/100 g (oven) to 3.35 (microwave) and 8.83 mg/100 g (oven), respectively. Oleic acid quantities of "Topak" and "Sivri" pumpkin oils were assayed to be between 37.79 (control) and 38.55 (microwave) to 35.32 (microwave) and 35.67% (control), respectively. Linoleic acid quantities of "Topak" and "Sivri" pumpkin seed oils were assessed to be between 42.74 (microwave) and 43.09 (control) to 44.78 (oven) and 45.24% (microwave), respectively. While the oleic acid content of roasted "Topak" pumpkin oils was higher than the control, the oleic acid content of "Sivri" pumpkin oil was lower.
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