Zhukova AG, Mikhailova NN, Yadykina TK
… +4 more, Alekhina DA, Gorokhova LG, Romanenko DV, Bugaeva MS
Med Tr Prom Ekol
· 2016 Aug · PMID 30351699
The authors studied intracellular liver protective mechanisms in development of chronic fluorine intoxication. Findings are that synthesis of protective proteins HIF-1α, HOx-1, HOx-2 and HSP72, restricting free radical o...The authors studied intracellular liver protective mechanisms in development of chronic fluorine intoxication. Findings are that synthesis of protective proteins HIF-1α, HOx-1, HOx-2 and HSP72, restricting free radical oxidation in hepatocytes increased in liver at early stages (1-3 weeks) of exposure to fluorine. At late terms of chronic fluorine intoxication (6-12 weeks), damaging effects of fluorine result from its genotixicity - ability to suppress synthesis of intracellular protective proteins and enzymes of main metabolic cycles in liver.
Panev NI, Zakharenkov VV, Korotenko OY
… +4 more, Filimonov SN, Panev RN, Gafarov NI, Luzina FA
Med Tr Prom Ekol
· 2016 Aug · PMID 30351698
To design forecasting system, the authors studied occurrence of atherosclerosis and its risk factors in 152 workers of coal mines in South Kouzbass (tunnellers, cleaning pit-face miners, mining excavator operators), suff...To design forecasting system, the authors studied occurrence of atherosclerosis and its risk factors in 152 workers of coal mines in South Kouzbass (tunnellers, cleaning pit-face miners, mining excavator operators), suffering from anthracosilicosis. Atherosclerosis was revealed in 124 (81.6%) workers with anthracosilicosis. With Bayess method for independent signs and Wald's sequential analysis method, the authors created a way to forecast atherosclerosis with coronary, extracranial and peripheral arteries involvement in miners with anthracosilicosis. Maximal risk of atherosclerosis in miners with anthracosilicosis is associated with following parameters: age 45 years and over, arterial hypertension, smoking, abdominal obesity type, diabetes mellitus, metabolic syndrome, respiratory failure, family history of IHD, hypercholesterolemia, increased LDL cholesterol, decreased HDL cholesterol, increased atherogeneity coefficient, hypertriglyceridemia, hyperhomocysteinemia, hyperfibrinogenemia, increased C-reactive protein, hypersthenic type according to Reese-Isenc index, andromorphic type according to Tanner index, blood group. markers A (II) and B (III), rhesus negative, MN and NN. Through increased number of factors analyzed and selected additional markers, accuracy of atherosclerosis forecasting is increased - that enables to proceed with opportune treatment and prevention.
Mikhailova NN, Zakharenkov VV, Bugaeva MS
… +4 more, Bondarev OI, Kazitskaya AS, Kizichenko NV, Ulanova EV
Med Tr Prom Ekol
· 2016 Aug · PMID 30351697
The studies revealed specificity of morphologic changes in target organs, depending on acting occupational hazard. Evidences are that inhalation of coal rock dust causes irreversible sclerotic and degenerative changes mo...The studies revealed specificity of morphologic changes in target organs, depending on acting occupational hazard. Evidences are that inhalation of coal rock dust causes irreversible sclerotic and degenerative changes mostly in lungs and bronchi even on 6th week of the experiment. In liver, changes in parenchyma and stroma are controlled by reparative processes by 9th week. Accumulation of sodium fluoride in the body causes irreversible necrotic changes mostly in liver, on 6th week of the intoxication. With that, morphologic changes in lungs and bronchi are minor, characterized by immune inflammation with degenerative changes only after the 9th week. Irrespective of the acting hazard, vascular changes are characterized by media and intima hypertrophy with endothelial dystrophy and hyalinosis since the 6th week of the experiment.
Fihmonov SN, Panev NI, Korotenko OY
… +1 more, Semenova EA
Med Tr Prom Ekol
· 2016 Aug · PMID 30351696
Complex medical examination covered 87 metallurgists of aluminium production with chronic fluorine intoxication and 43 metallurgists witout occupational diseases, aged 40 to 60, to evaluate factors associated with multi-...Complex medical examination covered 87 metallurgists of aluminium production with chronic fluorine intoxication and 43 metallurgists witout occupational diseases, aged 40 to 60, to evaluate factors associated with multi-focal atherosclerosis risk in aluminium production workers with chronic fluorine intoxication. Findings are increased incidence of ischemic heart disease and combined atherosclerosis of extracranial and peripheral arteries in workers with long exposure to fluorine compounds. Metallurgists with chronic fluorine intoxication appeared to have more frequent hyperfibrinogenemia and coronary personality type A, if compared to those without occupational diseases.
The authors accentuate the problem of preserving work potential of Russian population, most notable in industrial cities of Siberian federal district. Based on experience of Russian Federation outstanding scientists in i...The authors accentuate the problem of preserving work potential of Russian population, most notable in industrial cities of Siberian federal district. Based on experience of Russian Federation outstanding scientists in industrial medicine and environmental hygiene (Izmerov N.F., Prokopenko L.V., At'kov O.Yu., Belyaev E.N., Bukhtiyarov IV., BushmanovAYu., Vereshagin A.I., Golovkova N.P., Kouz'mina L.P., Matiukhin VV., Tikhonova G.I., Ushakov I.B., et al), in accordance with Russian President's Orders and under support of Siberian Medical academic society, professionals in Research Institute of complex problems in hygiene and occupational diseases (Director - professor Zakharenkov V.) carry out scientific basis for priority'directions of governmental policy in Siberian region up to the level of complex special-purpose programs that are supposed to include present aims and facilities of various departments for implementation. The article covers conceptual points and main principles of program solutions, and one out of mechanisms for practical implementation.
The author presents results in main scientific trends developed in the Institute since its foundation and prospects of further advances in public health and healthcare, hygiene, industrial medicine, human ecology.The author presents results in main scientific trends developed in the Institute since its foundation and prospects of further advances in public health and healthcare, hygiene, industrial medicine, human ecology.
The article characterizes sea work conditions under which crew-members carry occupational activitie's during the sail. Negative factors influencing health of crew members are listed. Among these factors, the major influe...The article characterizes sea work conditions under which crew-members carry occupational activitie's during the sail. Negative factors influencing health of crew members are listed. Among these factors, the major influence is caused by physical (noise, vibration, mechanical impacts, ionizing radiation varying in frequency), chemical, climate and.geographic, social an psychologic factors. Conclusion is that extreme work conditions of sailing staffers cause overstrain of adaptation systems, disorders of regulation fuctions, worsen health state and induce disablement. Within a system of medical care.for water transport workers, necessity is to have complex accounting of occupational hazards for more qualitative and safe work conditions.
Recently, the studies search possibilities to visualize and objectify sensory disorders in polyneuropathy caused by vibration. Special attention is paid on studies of injuried structures responsible for temperature and p...Recently, the studies search possibilities to visualize and objectify sensory disorders in polyneuropathy caused by vibration. Special attention is paid on studies of injuried structures responsible for temperature and pain sensitivity. Examination covered 92 patients with vibration disease, aged 34 to 73 years. Methods used are: pallesthesiometry, quantitative sensory tests, questionnaires and s 'cales of pain (visual analog scale (VAS) of pain, Pain-Detect, MPQ DN-, HADS). Correlation was found between.temperature, pain thresholds and VAS and pallesthesiometry parameters. The obtained results analysis indicates formation distal polyneuropathy syndrome of upper limbs with concomitant pain during vibration disease.
The authors defined main transgressions of law in sanitary epidemiologic well-being of population during sanitary epidemiologic examination of project materials for sanitary protective zones for enterprises, construction...The authors defined main transgressions of law in sanitary epidemiologic well-being of population during sanitary epidemiologic examination of project materials for sanitary protective zones for enterprises, constructions and other objects, and during determination of their final dimensions.
Existing practice implementing data obtained by occupational control and special evaluation of work conditions fails to evaluate hazardous effects caused in workers' health state by wide spectrum of risk factors such as...Existing practice implementing data obtained by occupational control and special evaluation of work conditions fails to evaluate hazardous effects caused in workers' health state by wide spectrum of risk factors such as social, ecologic, climate, etc. Widening possibilities for deeper health risk analysis can be provided by integration of laboratory and instrumental data on evaluation of hazardous and dangerous occupational factors into present systems of social hygienic monitoring. According to results of joint project within disciplinary program, Leningrad regional division of Federal Agency on sanitary epidemiologic supervision specified and implemented a regional model of integrated data base in informational funds of social hygienic monitoring. Consequently, quality and validity of management decisions in health risk factors control have significantly improved.i.
The article presents results proving significant advantage of ultrasound examination vs. X-ray contrast myography in diagnosis of occupational myofibrosis early stages. The authors recommend implementation of thi s metho...The article presents results proving significant advantage of ultrasound examination vs. X-ray contrast myography in diagnosis of occupational myofibrosis early stages. The authors recommend implementation of thi s method into medical examination practice for better diagnosis of occuptional myofibrosis to objectify decision on linking the disease with occupation.
The study covered health state of mine workers of "Apatit" enterprise according to periodic medical examination data in 2014. Medical workup covered 1360 miners of main, auxiliary occupations, with assessment of standard...The study covered health state of mine workers of "Apatit" enterprise according to periodic medical examination data in 2014. Medical workup covered 1360 miners of main, auxiliary occupations, with assessment of standardized intensive morbidity parameters. The analysis defined the most unfavorable health state of main occupations workers, with leading pathology of locomotory diseases, nervous system (polyneuritis) and ear disorders. These diseases could be caused by specific work conditions characterized by exposure to vibration, noise, intense physical exertion, cooling.
The authors examined algorithm of investigations in occupational pathology centers for suspected occupational polyneuropathy due to physical overload. Suggestions included a procedure to investigate the patients, includi...The authors examined algorithm of investigations in occupational pathology centers for suspected occupational polyneuropathy due to physical overload. Suggestions included a procedure to investigate the patients, including medical specialists consultations, set of laboratory and instrumental studies divided into obligatory and by special indications.
North-West Public Health Research Center, 4, 2-ya Sovetskaya str, S.-Petersburg, Russia, 191036 The authors reviewed toxicologic alternative investigation methods used in Russia for evaluation of occupational and natural...North-West Public Health Research Center, 4, 2-ya Sovetskaya str, S.-Petersburg, Russia, 191036 The authors reviewed toxicologic alternative investigation methods used in Russia for evaluation of occupational and natural environment.
Dudarev AA, Dushkina EV, Sladkova YN
… +2 more, Chupakhin VS, Lukicheva LA
Med Tr Prom Ekol
· 2016 Aug · PMID 29693823
Serum levels of zincum, lead, nickel and mercury decrease in a row <<males - females - pregnant>>; average levels of manganese, cobalt, copper and arsenic are higher among females; in pregnant women serum levels of most...Serum levels of zincum, lead, nickel and mercury decrease in a row <<males - females - pregnant>>; average levels of manganese, cobalt, copper and arsenic are higher among females; in pregnant women serum levels of most metals are the lowest. If compared to the WHO. reference, levels of metals in whole blood demonstrated no excess in cobalt and cadmium, nearly absent - in arsenic, increased percentage of excess (but insignificant values) in copper and zincum, extremely high percentage of excess (and significant values) in manganese and nickel. Maximal manganese concentrations in blood reach 300 micrograms/I, those of nickel - 100 micrograms/I. Average blood concentrations of mercury in the examinees do not reach the most severe <<level of concern for all ages>> (S micrograms/1), and shares of men and women with blood concentrations of mercury over this limit are relatively small. Average blood concentrations of lead in the examinees do not reach lower allowable level (50 micrograms/1).
The study covered features of work conditions, occupational risks and health state in 574 workers of automobile and railway transport, engaged into transportation of lobe rock in Kolsk Transpolar area. Findings are highe...The study covered features of work conditions, occupational risks and health state in 574 workers of automobile and railway transport, engaged into transportation of lobe rock in Kolsk Transpolar area. Findings are higher risk of occupationally conditioned (onychomycosis, obesit arterial hypertension and peptic ulcer of duodenum/stomach) and occupational diseases (neurosensory deafness, radiculopathy, vibration disease) in rock handler drivers. Conclusion was made on necessity to improve prophylaxis and treatment of health disorders in these workers.
The authors present analysis of changes in genera! morbidity related to age and length of service for truck drivers (chronic diseases of cardiovascular system, respiratory and digestive organs, urinary system, spine, loc...The authors present analysis of changes in genera! morbidity related to age and length of service for truck drivers (chronic diseases of cardiovascular system, respiratory and digestive organs, urinary system, spine, locomotory system and connective tissue) exposed to complex combination of occupational hazards (unusual work schedule, night shifts, air pollution with automobile transport exhaust gases). Morbid "ity parameters were calculated according to deep medical investigation results in periodic examinations of drivers and their appealability to medical office. General hygienic evaluation of work conditions was performed according to increment in risk of diseases for length of service years (annual risk increase). Difference of disease risk increase rates related to age and length of service was applied to determine occupational and non-occupational fractions of general morbidity in drivers working in hazardous conditions.
The authors present manterials on youth movement in medical science, on this trend development priorities in governmental policy, on main historical moments of its formation, on events for young scientists and specialist...The authors present manterials on youth movement in medical science, on this trend development priorities in governmental policy, on main historical moments of its formation, on events for young scientists and specialists, their role in advances and implementation of research work. These topics are exemplified on youth participation in medical science, hygiene and science on workers' health preservation--occupational medicine.
Bakirov AB, Shaikhlislamova ER, Valeyeva ET
… +4 more, Gimranova GG, Galimova RR, Beygul NA, Vagapova DM
Med Tr Prom Ekol
· 2016 · PMID 27396152
The authors represent data on analysis of dinamics and structure of occupational incidence in Bashkortostan Republic, according to archive documents of Ufa Research Institute of Occupational Health and Human Ecology, on...The authors represent data on analysis of dinamics and structure of occupational incidence in Bashkortostan Republic, according to archive documents of Ufa Research Institute of Occupational Health and Human Ecology, on occupational morbidity dynamics over 2008-2014, on its regional peculiarities.
Complex treatment using naphthalane applications with nonselective chromotherapy covered 64 engine operators of locomotive crews, aged 40-69 years, having 1-3 stage knee osteoarthrosis. Findings are that optimized treatm...Complex treatment using naphthalane applications with nonselective chromotherapy covered 64 engine operators of locomotive crews, aged 40-69 years, having 1-3 stage knee osteoarthrosis. Findings are that optimized treatment schedules effectively reduce intensity of pain, improve functional state of the joints involved, increase life quality of the patients, have no side effects. Comparative analysis of the treatment results showed that efficiency of combined naphthalane and nonselective chromotherapy exceeds isolated naphthalane effects.