Kokubyo Gakkai Zasshi. The Journal Of The Stomatological Society, Japan[JOURNAL]
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200 papers
Towards the Understanding of Tumor Microenvironment.
Watabe T
Kokubyo Gakkai Zasshi · 2016 Nov · PMID 30452828
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Inflammasome Activation and the Associating Diseases.
Suzuki T
Kokubyo Gakkai Zasshi · 2016 Nov · PMID 30452827
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[Survey of Dental Treatment Situation and Needs for Prostheses in Veterinary Practice].
Nakajima Y, Oki M, Sugimoto K … +1 more , Suzuki T
Kokubyo Gakkai Zasshi · 2016 Mar · PMID 27443071
PURPOSE: In today's society, pets have become important members of families since they give mental peace and healing to families. Although veterinary dentistry is recognized to be essential for animal health, there are f...
PURPOSE: In today's society, pets have become important members of families since they give mental peace and healing to families. Although veterinary dentistry is recognized to be essential for animal health, there are few reports on dental treatments of animals and the relationship between veterinarians and dental technicians. The purpose of the present study was to clarify the current situation of dental treatments of animals and to discuss the involvement of dental technicians in veterinary dental treatments and their collaboration with veterinarians. METHODS: Anonymous self-administered questionnaires were mailed to 16 university hospitals for animals, 17 animal clinics, and 87 zoological gardens, and handed out to 36 participants at the oral disease seminar organized by Nippon Animal Hospital Association. The questionnaires included questions on veterinary dental treatments, ways to learn veterinary dentistry, and details of prosthodontic treatments. RESULTS: Eighty-two valid responses (51.3%) were obtained. While 93.8% of veterinarians recognized the need for veterinary dental treatments, 67.9% were actually implementing dental treatments. Only 23.5% of veterinarians who conducted dental treatments experienced prosthodontic treatments, and the major prostheses used for treatments were fillings and crowns. Most veterinarians had fewer opportunities to acquire knowledge and skills about dental treatments. In addition, the recognition of dental technicians and their specialties was low among veterinarians. CONCLUSION: The results suggested that the dental technician, as a member of a multi-disciplinary team, can contribute to animal health by providing prosthetic appliances and should make efforts to enhance awareness of their specialty.
Differences between Computer-Based and Paper-Based Assessments of the Clinical Reasoning Competency of Dental Students.
Kurosa M, Tonami K, Ohara S … +5 more , Umemori S, Noritake K, Sunaga M, Kinoshita A, Araki K
Kokubyo Gakkai Zasshi · 2016 Mar · PMID 27443070
Clinical reasoning competency is essential for an appropriate clinical dental treatment. Among the tools for the assessment of clinical reasoning competency, computer-based testing (CBT) is considered more useful than pa...
Clinical reasoning competency is essential for an appropriate clinical dental treatment. Among the tools for the assessment of clinical reasoning competency, computer-based testing (CBT) is considered more useful than paper-based testing (PBT), because teachers can control the timing of information given to the examinees. Such timings could possibly affect the thinking process of examinees. However, few studies reported differences of reasoning between the two testing modes. In the present study, we developed an assessment of clinical reasoning and applied it using CBT and PBT to compare the examinees' performance. The participants comprised 60 students in the fifth-year class in 2012 of the School of Dentistry, Faculty of Dentistry, Tokyo Medical and Dental University. The tests comprised 25 problems, each with four questions, totaling 100 questions. The contents of the questions were the same in CBT and PBT. The students were assigned to CBT (Group C, n = 30) and PBT (Group P, n = 30) groups, with an almost equal gender ratio in the groups. The difference between scores was analyzed with a univariate analysis of variance. No significant intergroup differences were found regarding the test duration, total score, and average score of each question. The number of problems with perfect marks was higher in Group P than in Group C (P < 0.05), probably because Group P students could access the information of the previous question (s) within a problem. Thus, the differences of the examinees' performance between the two testing modes were small.
Extended Culture Conditions for Multipotent Bone Marrow-Derived Mesenchymal Stem Cells.
Zhang K, Ikeda Y, Kasugai S … +1 more , Ikeda M
Kokubyo Gakkai Zasshi · 2016 Mar · PMID 27443069
Mesenchymal stem cells (MSCs) offer a promising source of cells for musculoskeletal regeneration because of their potential to differentiate into bone, cartilage and fat. However, their proliferation and multilineage dif...
Mesenchymal stem cells (MSCs) offer a promising source of cells for musculoskeletal regeneration because of their potential to differentiate into bone, cartilage and fat. However, their proliferation and multilineage differentiation potential decreases with aging or increased time in in vitro culture. To determine culture conditions capable of enabling maintenance of MSCs for extended periods of time, human bone marrow-derived MSCs (BM-MSCs) were cultured in growth medium containing various combinations of growth factors and small chemical compounds. Upon reaching confluence, MSCs were subcultured continuously and then tested for differentiation capacity. After screening various growth factors and small chemical compounds, we found a combination capable of maintaining the proliferation potential of BM-MSCs obtained from a 19-year-old donor (young MSCs) up to passage 13 (P13). In contrast, unsupplemented MSCs reached senescence at P10. Total population doublings of control (P10) and supplemented MSCs (P12) were estimated at 20.4 and 42, respectively. Young MSCs cultured with supplements maintained osteogenic, adipogenic and chondrogenic differentiation capacities at P12 as confirmed by expression of lineage-specific differentiation markers. Furthermore, the supplementation of to BM-MSCs obtained from 65- and 79-year-old donors (aged MSCs) also continued to proliferate until P12, and maintained osteogenic and adipogenic differentiation capacity until P7 and P8, respectively, whereas, unsupplemented aged MSCs stopped proliferating at P8. These results indicate that our extended culture conditions maintained the proliferative capacity of young MSCs while retaining their multipotent differentiation potential, and improved both proliferation and differentiation of aged MSCs.
[Relationship between Occlusal Discomfort Syndrome and Occlusal Threshold].
Munakata M, Ono Y, Hayama R … +3 more , Kataoka K, Ikuta R, Tamaki K
Kokubyo Gakkai Zasshi · 2016 Mar · PMID 27443068
Occlusal dysesthesia has been defined as persistent uncomfortable feelings of intercuspal position continuing for more than 6 months without evidence of physical occlusal discrepancy. The problem often occurs after occlu...
Occlusal dysesthesia has been defined as persistent uncomfortable feelings of intercuspal position continuing for more than 6 months without evidence of physical occlusal discrepancy. The problem often occurs after occlusal intervention by dental care. Although various dental treatments (e. g. occlusal adjustment, orthodontic treatment and prosthetic reconstruction) are attempted to solve occlusal dysesthesia, they rarely reach a satisfactory result, neither for patients nor dentists. In Japan, these symptoms are defined by the term "Occlusal discomfort syndrome" (ODS). The aim of this study was to investigate the characteristics of ODS with the simple occlusal sensory perceptive and discriminative test. Twenty-one female dental patients with ODS (mean age 55.8 ± 19.2 years) and 21 age- and gender-matched dental patients without ODS (mean age 53.1 ± 16.8 years) participated in the study. Upon grinding occlusal registration foils that were stacked to different thicknesses, participants reported the thicknesses at which they recognized the foils (recognition threshold) and felt discomfort (discomfort threshold). Although there was no significant difference in occlusal recognition thresholds between the two patient groups, the discomfort threshold was significantly smaller in the patients with ODS than in those without ODS. Moreover, the recognition threshold showed an age-dependent increase in patients without ODS, whereas it remained comparable between the younger (< 60 years old) and elderly (60 years old or more) patient subgroups with ODS. These results suggest that occlusal discomfort threshold rather than recognition threshold is an issue in ODS. The foil grinding procedure is a simple and useful method to evaluate occlusal perceptive and discriminative abilities in patients with ODS.
[Treatment Strategy for Cervical Lymph Node Metastasis of Oral Carcinoma].
Harada H
Kokubyo Gakkai Zasshi · 2016 Mar · PMID 27443067
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Clinical Study of 597 Oral Squamous Cell Carcinomas in Our Department - Especially about 318 Tongue Carcinoma.
Mizutani M, Michi Y, Katsuki Y … +10 more , Ohyama Y, Uzawa N, Myo K, Kawamata A, Sumino J, Miura C, Morita T, Yamashiro M, Amagasa T, Yamaguchi S
Kokubyo Gakkai Zasshi · 2016 Jul · PMID 30452833
This clinico-statistical study includes 597 cases of oral squamous cell carcinoma treated at the Maxillofacial Surgery Section of Tokyo Medical and Dental University between January 2002 and December 2011. There were 373...
This clinico-statistical study includes 597 cases of oral squamous cell carcinoma treated at the Maxillofacial Surgery Section of Tokyo Medical and Dental University between January 2002 and December 2011. There were 373 male and 224 female patients (male to female ratio, 1.7 : 1), and the median age was 67 years. The tongue (53.3%) was the most commonly affected site. The 5-year disease-specific survival rate was 84.8%. Survival rates by clinical stage were as follows : Stage 1, 92.1% (n=195).; Stage , 86.0% (n = 221) ; Stage III, 77.7% (n=65) ; and Stage IV, 73.8% (n =116). Survival rates by primary site were as follows: tongue, 85.4% (n=318) ; lower gingiva, 82.8% (n =114) upper gingiva, 83.7% (n=59) ; buccal mucosa, 89.1% (n 54) ; oral floor, 81.4% (n=49) ; and hard palate, 100% (n=3). According to clinical growth patterns of Stage I / I tongue cancer cases, the 5-year disease-specific survival rate was significantly higher for patients with the exophytic/superficial type (97.3%, n =173) than for those with the endophytic type (77.5%, n=145). Among Stage I/II tongue cancer cases, the corresponding survival rate was significantly higher for patients who had not previously undergone invasive treatments (n=201), such as tooth extraction, compared to those who had previously done so (n=54) (92.7% and 79.7%, respectively). In addition, the incidence of secondary cervical lymph node metastasis was significantly higher in patients who had previously undergone invasive treatments.
The Scientific Works and Legacy of Prof. Dr. Dr. G. Steinhardt (1904-1995).
Igarashi Y
Kokubyo Gakkai Zasshi · 2016 Jul · PMID 30452832
No scientific papers are written without a thorough review of past works in related fields of research. I have worked as a scientist in prosthodontics for many years, and encountered papers 30 years ago regarding the bas...
No scientific papers are written without a thorough review of past works in related fields of research. I have worked as a scientist in prosthodontics for many years, and encountered papers 30 years ago regarding the basic concept of occlusal support in the course of researching prosthodontics written by German scientists in oral surgery. Prof. Dr. Dr. Gerhard Steinhardt was a clinical lecturer and scientist active in the 1930's to 70's in Germany. He made clinical achievements in maxillofacial surgery and the treatment of temporomandibular disorders related to occlusion, and wrote many scientific papers. In 1985 he gave me a set of slides outlining his achievements related to TM disorders, with a catalog of his papers. Upon retiring from TMDU, I am making the data available to members of the Stomatological Society of Japan. The original slides and data are preserved in the Society and are open to the public from now on.
Oral Function and Dysphagia Rehabilitation.
Furuya J
Kokubyo Gakkai Zasshi · 2016 Jul · PMID 30452831
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[Physicochemical and Biological Properties of Mineral Trioxide Aggregate as a Pulp Capping Material].
Okiji T
Kokubyo Gakkai Zasshi · 2015 Nov · PMID 26897926
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[Application to Individual Identification of Parastic Virus Genotypes].
Sakurada K
Kokubyo Gakkai Zasshi · 2015 Nov · PMID 26897925
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[Outcomes of Infection Control Team Inspections at the Dental Hospital, Tokyo Medical and Dental University].
Sunakawa M, Matsumoto H, Okihata R … +4 more , Tsuruoka H, Yamada Y, Adachi T, Izumi Y
Kokubyo Gakkai Zasshi · 2015 Jul · PMID 26502663
In the Dental Hospital, Tokyo Medical and Dental University, an infection control team (ICT) has been formed to inspect each diagnosis department of clinics and wards in order to identify problems regarding nosocomial in...
In the Dental Hospital, Tokyo Medical and Dental University, an infection control team (ICT) has been formed to inspect each diagnosis department of clinics and wards in order to identify problems regarding nosocomial infection control. In this study, we analyzed the inspection reports and highlighted the following serious problems: 1) inadequate hygienic hand-washing for out- and in-patient treatment, 2) incomplete wearing of personal protective equipment (PPE) by dental health care workers, 3) necessity of environmental improvement in the clinics, and 4) cross-infection risk induced by. the continuous use of treatment devices without appropriate disinfection. The ICT provided feedback to the inspected departments, suggesting solutions to problems regarding nosocomial infection control. In order to enhance infection control in our hospital, dental healthcare practitioners must make further efforts on nosocomial infection control and prevention, and act according to their position by continuously educating students and enlightening hospital staff about the importance of infection control.
Exploration of Alternative Mechanism for MiR-596-mediated Down-regulation of LGALS3BP in Oral Squamous Cell Carcinoma.
Li H
Kokubyo Gakkai Zasshi · 2015 Jul · PMID 26502662
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that negatively regulate gene expression via binding to the 3' -untranslated region (UTR) of transcripts. However, recent evidence suggests that miRNA can also bind...
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that negatively regulate gene expression via binding to the 3' -untranslated region (UTR) of transcripts. However, recent evidence suggests that miRNA can also bind to the open reading frame (ORF) region within transcripts for its down-regulation. On the other hand, a previous report demonstrated that miR-596 has a tumor suppressor function by targeting LGALS3BP via directly binding to its 3' UTR in oral squamous cell carcinoma (OSCC) cells. However, it is not clear whether this miRNA can bind to the ORF region of LGALS3BP. In this study, although four putative binding sites of miR-596 were included within the ORF region of LGALS3BP, it was found that miR-596 could not bind to those sites. Instead, the results showed that the expression of LGALS3BP might be in part negatively regulated by the proteasome system at the protein level. Thus, these findings may help clarify the molecular mechanism of the tumor-suppressive effect through down-regulation of LGALS3BP by miR-596 in OSCC cells.
[GLP-1 receptor expression in rat major salivary glands and the effects of bilateral maxillary molar extraction on its expression].
Ono R
Kokubyo Gakkai Zasshi · 2015 Mar · PMID 26043556
Glucagon-like peptide 1 (GLP-1) is the gastrointestinal hormone released from L-cells of the small intestine and promotes insulin secretion by acting on the pancreas islet. GLP-1 receptor (GLP-1R) expression has been det...
Glucagon-like peptide 1 (GLP-1) is the gastrointestinal hormone released from L-cells of the small intestine and promotes insulin secretion by acting on the pancreas islet. GLP-1 receptor (GLP-1R) expression has been detected in many organs that are involved in carbohydrate metabolism, however its expression in the salivary glands, which participate in the first carbohydrate metabolism, has not been clarified yet. Furthermore, it is known that occlusion affects both the morphology and function of the salivary glands. Thus in this study, we focused on the expression of GLP-1R in the major salivary glands, and analyzed the changes of GLP-1R expression under the occlusal changes. Twenty-four male Wistar rats were used in this study. In the experimental group, all maxillary molars were extracted at 7 weeks old. The rats without molar extraction were used as the control group. The rats were sacrificed at 8 and 11 weeks old, then the parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG) were analyzed immunohistochemically for the presence of GLP-1R. Immunohistochemical staining showed GLP-1R to be localized in the ductal cells of PG, SMG, and SLG. In SLG, there were no differences in the intensity of GLP-1R staining in both the control and experimental groups at 8 and 11 weeks old. In PG and SMG, the intensity of GLP-1R staining in the experimental group was significantly weaker than in the control group at 11 weeks old, otherwise there were no differences at 8 weeks old. In conclusion, GLP-1R is expressed in rat PG, SMG, and SLG, and its expression can be influenced by molar extraction.
[Flipped classroom as a strategy to enhance active learning].
Wakabayashi N
Kokubyo Gakkai Zasshi · 2015 Mar · PMID 26043555
This paper reviews the introduction of a flipped class for fourth grade dentistry students, and analyzes the characteristics of the learning method. In fiscal 2013 and 2014, a series of ten three-hour units for removable...
This paper reviews the introduction of a flipped class for fourth grade dentistry students, and analyzes the characteristics of the learning method. In fiscal 2013 and 2014, a series of ten three-hour units for removable partial prosthodontics were completed with the flipped class method; a lecture video of approximately 60 minutes was made by the teacher (author) and uploaded to the university's e-learning website one week before each class. Students were instructed to prepare for the class by watching the streaming video on their PC, tablet, or smartphone. In the flipped class, students were not given a lecture, but were asked to solve short questions displayed on screen, to make a short presentation about a part of the video lecture, and to discuss a critical question related to the main subject of the day. An additional team-based learning (TBL) session with individual and group answers was implemented. The average individual scores were considerably higher in the last two years, when the flipped method was implemented, than in the three previous years when conventional lectures were used. The following learning concepts were discussed: the role of the flipped method as an active learning strategy, the efficacy of lecture videos and short questions, students' participation in the class discussion, present-day value of the method, cooperation with TBL, the significance of active learning in relation with the students' learning ability, and the potential increase in the preparation time and workload for students.
[An oral function improvement program utilizing health behavior theories ameliorates oral functions and oral hygienic conditions of pre-frail elderly persons].
Sakaguchi H
Kokubyo Gakkai Zasshi · 2014 Jun · PMID 25244722
Oral function improvement programs utilizing health behavior theories are considered to be effective in preventing the need for long-term social care. In the present study, an oral function improvement program based upon...
Oral function improvement programs utilizing health behavior theories are considered to be effective in preventing the need for long-term social care. In the present study, an oral function improvement program based upon health behavior theories was designed, and its utility was assessed in 102 pre-frail elderly persons (33 males, 69 females, mean age: 76.9 +/- 5.7) considered to be in potential need of long-term social care and attending a long-term care prevention class in Sayama City, Saitama Prefecture, Japan. The degree of improvement in oral functions (7 items) and oral hygienic conditions (3 items) was assessed by comparing oral health before and after participation in the program. The results showed statistically significant improvements in the following oral functions: (1) lip functions (oral diadochokinesis, measured by the regularity of the repetition of the syllable "Pa"), (2) tongue functions, (3) tongue root motor skills (oral diadochokinesis, measured by the regularity of the repetition of the syllables "Ta" and "Ka"), (4) tongue extension/retraction, (5) side-to-side tongue movement functions, (6) cheek motor skills, and (7) repetitive saliva swallowing test (RSST). The following measures of oral hygiene also showed a statistically significant improvement: (1) debris on dentures or teeth, (2) coated tongue, and (3) frequency of oral cleaning. These findings demonstrated that an improvement program informed by health behavior theories is useful in improving oral functions and oral hygiene conditions.
[Nuclear translocation of epidermal growth factor receptor and its relation to clinicopathological factors in oral squamous cell carcinomas].
Taguchi T
Kokubyo Gakkai Zasshi · 2014 Mar · PMID 24812767
The epidermal growth factor receptor (EGFR) is one of the receptor tyrosine kinases. Some EGFRs are transferred from membrane to nucleus upon ligand binding and an increase of this translocation causes high-level express...
The epidermal growth factor receptor (EGFR) is one of the receptor tyrosine kinases. Some EGFRs are transferred from membrane to nucleus upon ligand binding and an increase of this translocation causes high-level expression of nuclear EGFR. The high-level expression of nuclear EGFR was reported to be a poor prognostic factor in various cancers such as breast cancer, ovarian cancer, gallbladder cancer, prostate cancer and oropharyngeal cancer. Regarding oral cancers, one report indicated that nuclear EGFR is detected in oral squamous cell carcinoma (OSCC) on immunohistochemical staining, but did not mention the clinicopathological prognostic value in detail. Therefore, we investigated the expression of nuclear EGFR in OSCC cell lines and primary tumor specimens of tongue SCCs to see whether nuclear EGFR could be a useful prognostic value. We verified the expression level of nuclear EGFR in OSCC cell lines and observed an increase in the amount of nuclear EGFR upon EGF stimulation with the expression level reaching its peak after 15 minutes. Nuclear EGFR positive tumors were found in 23 patients (28.0%) with tongue SCCs. However, we could not find any correlation between clinicopathological factors and the expression of nuclear EGFR in patients with tongue SCCs.
[Effects of shortened mandibular dental arch on human brain activity during chewing: an fMRI study].
Shoi K
Kokubyo Gakkai Zasshi · 2014 Mar · PMID 24812766
According to the shortened dental arch concept, missing molars should not always be restored with prosthetic treatment. A shortened dental arch with missing molars is associated with a decrease in masticatory function. H...
According to the shortened dental arch concept, missing molars should not always be restored with prosthetic treatment. A shortened dental arch with missing molars is associated with a decrease in masticatory function. However, it is not known whether a shortened dental arch influences brain activity during chewing. This study aimed to clarify the effect of posterior arch length of mandibular bilateral distal extension removable partial dentures (RPDs) on brain activity during chewing. Eleven subjects with bilaterally missing mandibular molars (mean age, 66.1 years) participated in the study. RPDs with full dental arch and shortened dental arch were fabricated and brain activity during gum chewing under each dental condition was measured using functional magnetic resonance imaging. Brain activation during gum chewing with the full dental arch was observed in the middle frontal gyrus, primary sensorimotor cortex extending to the premotor cortex, supplementary motor area, putamen, insula and cerebellum. However, activation of the middle frontal gyrus was not observed during gum chewing with the shortened dental arch. The results of this study suggest that human brain activity during chewing in the middle frontal gyrus may be associated with chewing in the presence of the molar region.
[An investigation of oral colonization by Candida albicans in immunodeficient animal with decreasing saliva volume].
Kinoshita Y
Kokubyo Gakkai Zasshi · 2014 Mar · PMID 24812765
Candida albicans is a commensal fungus that commonly colonizes human mucosal surfaces. When the host immune defenses are impaired, C. albicans triggers recurrent infections of the oral mucosa and tongue. We previously re...
Candida albicans is a commensal fungus that commonly colonizes human mucosal surfaces. When the host immune defenses are impaired, C. albicans triggers recurrent infections of the oral mucosa and tongue. We previously reported that the characteristics in NOD/SCID. e2f1(-/-) mice that have naturally decreased saliva and T and B cells that do not develop increase the susceptibility of oral bacterial infection in the oral cavity. Next, we sought to establish a C. albicans infection model in NOD/SCID. e2f1(-/-) mice. C. albicans yeast forms were introduced by wiping a cotton swab moistened with C. albicans solution on the tongue after disinfection by 0.2 Chlorhexidine for the first time. After an interval of 60 min, the inoculation was performed by pipette 2 or 4 times at an interval of 60 min. The number of C. albicans colonized on the tongue significantly increased but there were no significant difference between NOD/SCID. e2f1(+/+) mice and NOD/SCID. e2f1(-/-) mice at 120-240 minutes. However, a significant difference between these mice was observed at 24 hours after the last inoculation. Moreover, 5 inoculations/day were also performed for 2-4 days and significant differences between mice arose, and the maximum level of infection was found at 24 hours after consecutive inoculation for 3, 4 and 5 days, but the levels were reduced after 48 h. It is suggested that the saliva volume and flow are important for preventing 24-hour colonization of C. albicans. NOD/SCID. e2f1(-/-) mice are a relevant mouse model for 24-hour colonization on the tongue.
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