Kokubyo Gakkai Zasshi. The Journal Of The Stomatological Society, Japan[JOURNAL]
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200 papers
[The time-course change of brain activity during learning new movement patterns of pronunciation with orthodontic appliances and its correlation with self-evaluation of pronunciation difficulty: an fMRI study].
Kaneshima T
Kokubyo Gakkai Zasshi · 2014 Mar · PMID 24812764
Pronunciation requires speed and accuracy, like many other fundamental activities such as breathing, eating, and walking. People can pronounce almost automatically without paying much attention to correctness, also like...
Pronunciation requires speed and accuracy, like many other fundamental activities such as breathing, eating, and walking. People can pronounce almost automatically without paying much attention to correctness, also like other activities. However, people may have to focus carefully on pronunciation when learning a foreign language, wearing dental appliances or rehabilitating after an injury or disease that affects speech. In the present study, we investigated neural changes underlying the process of learning new movement patterns of pronunciation in such cases. Nine healthy adults participated in the study. Difficulty of pronunciation was evaluated and cortical activity was measured under three conditions (overt and covert speaking, and silent reading) by fMRI three times after they wore orthodontic appliances. We found that the right superior temporal gyrus (STG) was involved in the auditory feedback control of pronunciation with the appliances, and the activity of the right STG was well correlated with the subjective difficulty of pronunciation and its time-dependent reduction. On the other hand, neural changes related to somatosensory feedback control and motor control of pronunciation did not show any time-dependent change. Our findings indicate that auditory feedback control of pronunciation is more important than motor control and somatosensory feedback control for learning new movements related to pronunciation.
[Comparison of fibroblastic cell compatibility of type I collagen-immobilized titanium between electrodeposition and immersion].
Kyuragi T
Kokubyo Gakkai Zasshi · 2014 Mar · PMID 24812763
Titanium is widely used for medical implants. While many techniques for surface modification have been studied for optimizing its biocompatibility with hard tissues, little work has been undertaken to explore ways of max...
Titanium is widely used for medical implants. While many techniques for surface modification have been studied for optimizing its biocompatibility with hard tissues, little work has been undertaken to explore ways of maximizing its biocompatibility with soft tissues. We investigated cell attachment to titanium surfaces modified with bovine Type I collagen immobilized by either electrodeposition or a conventional immersion technique. The apparent thickness and durability of the immobilized collagen layer were evaluated prior to incubation of the collagen-immobilized titanium surfaces with NIH/3T3 mouse embryonic fibroblasts. The initial cell attachment and expression of actin and vinculin were evaluated. We determined that the immobilized collagen layer was much thicker and more durable when placed using the electrodeposition technique than the immersion technique. Both protocols produced materials that promoted better cell attachment, growth and structural protein expression than titanium alone. However, electrodeposition was ultimately superior to immersion because it is quicker to perform and produces a more durable collagen coating. We conclude that electrodeposition is an effective technique for immobilizing type I collagen on titanium surfaces, thus improving their cytocompatibility with fibroblasts.
[A clinical investigation of new patients who had already received treatment with dental implants at other clinics in seventeen years].
Yukawa K, Tachikawa N, Munakata M … +2 more , Shiota M, Kasugai S
Kokubyo Gakkai Zasshi · 2014 Mar · PMID 24812762
The purpose of this study was to investigate new patients who had already received treatment with dental implants. The subjects were patients who visited the clinic for oral implants at Tokyo Medical and Dental Universit...
The purpose of this study was to investigate new patients who had already received treatment with dental implants. The subjects were patients who visited the clinic for oral implants at Tokyo Medical and Dental University Hospital from April 1995 to March 2012. The results were as follows: 1) Of the total number of patients, there were 2,419 patients (14.0%) with dental implants. 2) Of the 2,419 patients, 252 patients (10.4%) had been referred from operating doctors or operating clinics. 3) There were 1,516 (62.7%) patients with complaints related to the implant therapy. 4) There were 1,367 (56.5%) patients who had ill feelings toward their attending doctors. 5) There were 1,112 (46.0%) patients with biological complications. 6) Regarding patients with or without a referral from the doctor who had performed their dental implant, those patients who had been referred showed significantly higher occurrence of loss of implants, neurological symptoms, doctor's recommendation, prosthetic problems, and surgical problems. Almost implant therapies were treated with other treatments for natural teeth, including surgical treatment, prosthetic treatment, periodontal treatment and maintenance. These were too complex to enable the results to be forecast before treatment, therefore unpredictable symptoms often occur in patients with implant therapy. Informed consent including patient education is important, but the results of this study suggest that it is insufficient at present.
[Regulation mechanism of bone remodeling].
Nakashima T
Kokubyo Gakkai Zasshi · 2013 Oct · PMID 24341173
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[Influence of contributing factors in temporomandibular disorders in female college students].
Nakayama R, Nishiyama A, Kino K … +1 more , Yoshimasu H
Kokubyo Gakkai Zasshi · 2013 Jun · PMID 23986955
This study was performed to ascertain any relationship between temporomandibular disorders (TMD) and contributing factors such as tooth contacting habit (TCH) that influence the manifestation of TMD and TCH in graduate f...
This study was performed to ascertain any relationship between temporomandibular disorders (TMD) and contributing factors such as tooth contacting habit (TCH) that influence the manifestation of TMD and TCH in graduate female college students. The subjects were 114 graduate female college students in Oral Health Care Sciences, Faculty of Dentistry, Tokyo Medical and Dental University. The subjects were assessed using a questionnaire and observation of tongue indentation and buccal mucosa ridging. Of these students, 89 (78.1%) answered the questionnaire. Statistical examinations were performed using t-tests and logistic regression analyses. A p value of less than 0.05 was considered to be a significant difference. The prevalence rate of TMD was 16 (19.3%) and the prevalence rate of TCH was 39 (47.0%). Logistic regression analyses indicated that unilateral chewing, presence of tongue indentation, and buccal mucosa ridging were significant contributors to the manifestation of TMD. In addition, these analyses indicated that sleep disorders and physical pain such as headaches and neck pain were significant contributors to the manifestation of TCH. This study suggested the following: unilateral chewing, presence of tongue indentation, and buccal mucosa ridging could correlate with the manifestation of TMD. In addition, sleep disorders, headaches, and neck pains could correlate with the manifestation of TCH.
[Relationship between oral health status and life behavior in junior and senior high school students in Japan].
Shizuma Y, Shinada K, Kondo K … +1 more , Endo K
Kokubyo Gakkai Zasshi · 2013 Jun · PMID 23986954
A survey of dental diseases carried out by the Ministry of Health, Labour and Welfare in 2003 revealed that more than 40% of people aged between 5 and 25 suffer from periodontal diseases and the average number of DMFT ha...
A survey of dental diseases carried out by the Ministry of Health, Labour and Welfare in 2003 revealed that more than 40% of people aged between 5 and 25 suffer from periodontal diseases and the average number of DMFT has been decreasing. The lifestyle of junior and senior high school students in particular has changed drastically. This study investigated the relationship between dietary habits and oral diseases in junior and senior high school students in Tokyo. Survey responses were received from 813 of 848 students. There was a significant correlation between the presence of untreated teeth and student's dietary habits, or the presence of periodontal diseases. These results suggest that dental hygienists need to consider providing advice on appropriate eating habits during dental hygiene instruction to students.
[Three kinds of speech evaluation in maxillectomy patients during the fabrication process of a hollow-type obturator].
Hattori M, Sumita Y, Taniguchi H
Kokubyo Gakkai Zasshi · 2013 Jun · PMID 23986953
Speech evaluation is essential to the rehabilitation of maxillectomy patients. A speech intelligibility test has been frequently used for the evaluation because of its simplicity. However, the test needs human listeners...
Speech evaluation is essential to the rehabilitation of maxillectomy patients. A speech intelligibility test has been frequently used for the evaluation because of its simplicity. However, the test needs human listeners and this has been a shortcoming of the test. Thus, objective evaluation methods have been discussed. One of them is formant analysis for vowel evaluation and another is psychoacoustic analysis for consonants. In this research, to evaluate the speech in five maxillectomy patients, the F2-range was examined as formant analysis and the sharpness of /sa/ was examined as psychoacoustic analysis, in addition to the speech intelligibility test, during the fabrication process of a hollow-type obturator. The objective evaluation of patients' speech was effectively performed using those three methods. The F2-range was larger, the sharpness of /sa/ was higher and the speech intelligibility was higher when patients wore an obturator compared to when patients did not wear an obturator. The difference in speech when changing the types of obturator was not clear. The method and the findings are important for future research in this field, since speech is one of the important factors in maxillofacial rehabilitation.
[Basic characteristics and clinical application of ozone nano-bubble water].
Arakawa S
Kokubyo Gakkai Zasshi · 2013 Mar · PMID 23898470
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[Role of ARID3A in E2F target gene expression and cell growth].
Saadat KA
Kokubyo Gakkai Zasshi · 2013 Mar · PMID 23659165
UNLABELLED: ARID3A is a member of the AT-rich interaction domain (ARID) family of DNA-binding proteins. ARID3A was isolated as proteins binding to E2F1, and stimulates transcription mediated by the E2F transcription fact...
UNLABELLED: ARID3A is a member of the AT-rich interaction domain (ARID) family of DNA-binding proteins. ARID3A was isolated as proteins binding to E2F1, and stimulates transcription mediated by the E2F transcription factor that plays a central role in regulating cell cycle progression. However, the function of ARID3A in E2F-target-gene expression has not been fully understood. METHODS: Gene-silencing and overexpression experiments were carried out using siRNA and recombinant adenoviruses, respectively. E2F responsive gene expression was measured by RT-PCR. Effects of ARID3A silencing on DNA synthesis and cell growth were determined by EdU incorporation and colony formation assay, respectively. RESULTS: siRNA mediated gene silencing of ARID3A blocked the transcription of E2F-target genes, such as E2F1, p107, CDC2 and CDC6 in normal human dermal fibroblasts (NHDFs). Although adenoviral-mediated overexpression of ARID3A did not up-regulate the transcription of these E2F-target genes in quiescent NHDFs, E2F1 overexpression was unable to overcome the blockade of CDC6 expression by ARID3A silencing. Furthermore, ARID3A silencing attenuated S phase entry of NHDFs, and suppressed growth of human tumor cell lines. CONCLUSION: These results indicate that ARID3A plays an important role for E2F-mediated transcriptional activation and cell growth.
[Changes in ingestive behavior during growth affects the functional maturation of temporomandibular joint nociceptive neurons of rats].
Hiranuma M
Kokubyo Gakkai Zasshi · 2013 Mar · PMID 23659164
Temporomandibular joint (TMJ) loading during development promotes its growth and maintains normal structure/function. Continuous change in diet consistency is related to development and maturation of the peripheral nervo...
Temporomandibular joint (TMJ) loading during development promotes its growth and maintains normal structure/function. Continuous change in diet consistency is related to development and maturation of the peripheral nervous system, including the nociceptive system. However, the functional modulation of TMJ-nociceptive neurons under different ingestive behavior is unclear. We fed growing rats a liquid diet to investigate the effects of low TMJ loading on the response properties of neurons in the trigeminal spinal tract subnucleus caudalis (Sp5C). Forty 2-week-old male rats were used. They were fed chow pellets (n = 20, C group) or a liquid diet (n = 20, LD group) soon after weaning. Firing activities of single sensory units in response to TMJ pressure stimuli were recorded at 4, 5, 7 and 9 weeks. In TMJ-nociceptive neurons, the firing threshold (FT) in the LD group was significantly lower than that in the C group at each recording age. The FT in the C group remained unchanged throughout the recording period, whereas that in the LD group was the highest at 4 weeks, and gradually decreased. On the other hand, the initial firing frequency (IFF) was significantly higher in the LD group than in the C group at each recording age. The IFF in the C group remained unchanged throughout the experimental period, whereas that in the LD group was at its lowest at 4 weeks, and gradually increased. Based on these findings, ingestive behavior that results from continuous changes in the physical consistency of the diet during growth may affect the functional maturation of TMJ-nociceptive neurons.
[Effects of hyaluronan tetrasaccharide on the differentiation of neuronal cells and oligodendrocyte precursor cells].
Yamanokuchi H
Kokubyo Gakkai Zasshi · 2012 Oct · PMID 23327092
It has been reported that hyaluronan tetrasaccharide (HA4) has an ability to accelerate the healing process of spinal cord injuries and to mitigate the symptoms of experimental autoimmune encephalitis (EAE) in animal mod...
It has been reported that hyaluronan tetrasaccharide (HA4) has an ability to accelerate the healing process of spinal cord injuries and to mitigate the symptoms of experimental autoimmune encephalitis (EAE) in animal models. However, the precise mechanisms of the effect of HA4 are unclear. This study examined the in vitro effects of HA4 on the differentiation of PC12 cells and neuronal progenitor cells from mouse embryo. The effect of HA4 on the proliferation and differentiation of rat oligodendrocyte precursor cells was examined. HA4 upregulated neurite-outgrowth of cultured PC12 cells in the presence of Nerve Growth Factor (NGF), which induces neuronal differentiation in PC12. HA4 also upregulated beta III-tubulin positive cells and increased the expression of neurofilament M, two of the marker proteins of nerve differentiation. The activation was observed in an HA4 dose-dependent manner, and the effect was observed at levels as low as femtogram/L. Furthermore, the enhancement of neurite-outgrowth was not observed in the presence of hyaluronan disaccharide, hexasaccharide, 12 mer or high molecular weight hyaluronan. Upregulation of neurite-outgrowth was observed only in the presence of NGF. While HA4 accelerated neurite-outgrowth of primary mouse neural progenitor cells, it did not enhance the proliferation or differentiation of oligodendrocyte precursor cells derived from rat primary neuronal progenitor cells in culture. These results suggest that the effects of HA4 alleviating some neuronal diseases may be ascribable, at least in part, to its capacity to enhance differentiation of neurons.
[Effects of oral health care for lung cancer patients with surgery--improvement of cough reflex].
Yamada C
Kokubyo Gakkai Zasshi · 2012 Oct · PMID 23327091
The number of lung cancer patients is increasing. One complication of particular concern after surgery for lung cancer is postoperative pneumonia. The present study examined the various effects of oral care cough reflexe...
The number of lung cancer patients is increasing. One complication of particular concern after surgery for lung cancer is postoperative pneumonia. The present study examined the various effects of oral care cough reflexes (cough reflex test), oral health conditions (OAG and face scale), and immune function (NK cell activity) in patients who underwent surgery for lung cancer. Subjects included 60 patients aged 75 years old or younger who were scheduled to undergo surgery for stage I lung cancer. The average age was 65.3 +/- 6.0 years old. We randomly divided the subjects into an oral care group and a control group. In the oral care group, we observed a significant increase in the normal rate of cough reflex test postsurgery, relative to pre-surgery. In contrast, no significant change in the normal rate of cough reflex test was noted for patients in the control group. Oral health conditions showed similar results. While we observed no significant change in NK cell activity from between pre-surgery and post-surgery in the oral care group, we did note a significant decrease in the control group. Two cases of pneumonia after surgery were identified in the control group. The oral care group did not get postoperative pneumonia. Thus, it was shown that oral care is related to cough reflex, oral health conditions, and immune function.
[To aim for safe and effective orthognathic surgery].
Harada K
Kokubyo Gakkai Zasshi · 2012 Oct · PMID 23327090
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[Detection of FADD gene amplification in oral leukoplakia].
Yoshimoto M
Kokubyo Gakkai Zasshi · 2012 Jun · PMID 22838074
UNLABELLED: The Fas-associated death domain containing protein, FADD, is an adaptor for relaying apoptotic signals. However, recent studies have shown that FADD also plays an important role in the growth and regulation o...
UNLABELLED: The Fas-associated death domain containing protein, FADD, is an adaptor for relaying apoptotic signals. However, recent studies have shown that FADD also plays an important role in the growth and regulation of the cell cycle, and FADD gene amplifications were observed in oral squamous cell carcinoma (OSCC). The purpose of this study was to elucidate the role of FADD in oral leukoplakia, known as potentially malignant disorder. METHODS: The gene amplifications of FADD from the fresh-frozen tissues and the formalin-fixed paraffin-embedded tissues of 51 patients who underwent biopsy or surgical resection of oral leukoplakia were detected: singleplex and multiplex assays were employed. RESULTS: The gene amplifications of FADD were detected in the samples of 3 patients who were diagnosed pathologically with severe epithelial dysplasia or early invasive carcinoma. CONCLUSION: Because the gene amplifications of FADD were observed in early invasive carcinoma rather than precancerous lesions, the FADD gene amplification was not useful for the predictive marker of cancerization and is possibly related to the malignancy of OSCC including metastatic potential.
[Clinicopathological study of calcifying cystic odontogenic tumors].
Murashima M, Michi Y, Kurohara K … +5 more , Iijima S, Suzuki M, Kawamata A, Okada N, Yamashiro M
Kokubyo Gakkai Zasshi · 2012 Mar · PMID 22568079
Calcifying cystic odontogenic tumors are benign tumors, characterized by the presence of ghost cells and calcified materials. We evaluated clinical characteristics of calcifying cystic odontogenic tumors in 21 cases at t...
Calcifying cystic odontogenic tumors are benign tumors, characterized by the presence of ghost cells and calcified materials. We evaluated clinical characteristics of calcifying cystic odontogenic tumors in 21 cases at the Maxillofacial Surgery, Tokyo Medical and Dental University Hospital, between January 1979 and December 2006. Of the 21 lesions that were studied, 12 were observed in male patients, and 9 in female patients. The median age was 13.0 years (range, 4-69 years). Of the 21 lesions, 11 were located in the maxilla (intraosseous), 9 in the mandible (intraosseous), and 1 in the lower gingiva (extraosseous). Radiographically, 18 lesions appeared as unilocular radiolucencies, and 2 lesions as multilocular radiolucencies. Impacted teeth were observed in 15 cases. In 20 cases, the lesions were treated by enucleation. The follow-up duration ranged from 2 years, 5 months to 28 years, 8 months, and in 1 case, the lesion recurred and showed a malignant transformation 2 years 10 months after the treatment. Histopathologically, the lining epithelium consisted of cuboidal or columnar odontogenic cells. Ghost cells were frequently calcified, and the tissue was hardened. In 14 cases, the tumor was associated with odontoma.
[Involvement of tissue interaction between cranial neural crest cells, their pathways lateral to the midbrain hindbrain border and the buccopharyngeal membrane in Meckel's cartilage formation in avian embryos].
Imai H
Kokubyo Gakkai Zasshi · 2012 Mar · PMID 22568078
Cranial neural crest cells migrate to the craniofacial primordia and differentiate into skeletal tissues of the jaw such as Meckel's cartilage. It has not been clearly demonstrated how neural crest cells are committed to...
Cranial neural crest cells migrate to the craniofacial primordia and differentiate into skeletal tissues of the jaw such as Meckel's cartilage. It has not been clearly demonstrated how neural crest cells are committed to differentiate into these tissues. In this study, the conditions that are required for the formation of Meckel's cartilage were investigated. In situ hybridization in chick embryos indicated that Fgf8 and Shh involved in the pattern formation of limb cartilages were expressed in the neural tube of the midbrain-hindbrain border, the buccopharyngeal membrane and the oro-proximal site of the 1st branchial arch (oro-proximal BA1). Cell-tracing with DiI confirmed that the neural crest cells derived from both the posterior midbrain and rhombomere 1 migrated to the buccopharyngeal membrane, which subsequently forms oro-proximal BA1, by passing through the mesenchyme lateral to the midbrain-hindbrain boundary. Based on the above results, we carried out two types of ectopic transplantation experiments by chick-quail chimera The graft of oro-proximal BA1, the complex of epithelium and mesenchyme, formed a Meckel's cartilage-like structure in a self-differentiation manner, whereas neither epithelium only nor mesenchyme formed any elongated cartilage. The ectopic transplant of the buccopharyngeal membrane into the mesenchyme lateral to the neural tube of the mid-hindbrain border in which neural crest cells were migrating formed a Meckel's cartilage-like structure. These results suggest that the cranial neural crest cells derived from the mid-hindbrain region are committed to the cell fate during migration, and receive further signaling to differentiate into Meckel's cartilage in their destination.
[Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells].
Haruta C
Kokubyo Gakkai Zasshi · 2012 Mar · PMID 22568077
A functional endocannabinoid system is present in several mammalian organs and tissues. The endogenous cannabinoid anandamide (AEA) is a bioactive lipid neurotransmitter that is present in a variety of tissues and has mu...
A functional endocannabinoid system is present in several mammalian organs and tissues. The endogenous cannabinoid anandamide (AEA) is a bioactive lipid neurotransmitter that is present in a variety of tissues and has multiple functions. Recently, this cannabinoid system was reported to play important roles in osteoblastic and osteoclastic cells. Human periodontal ligament (hPDL) cells modulate alveolar bone remodeling by producing cytokines when stimulated by many factors. The aim of this study was to investigate the AEA level in periodontal regions and the osteogenic effect of AEA on hPDL cells. The levels of AEA in the gingival crevicular fluid (GCF) of periodontitis patients were measured using liquid chromatography/mass spectrometry (LC/MS). Expressions of cannabinoid receptor mRNA were detected by RT-PCR in hPDL cells and expression of the transient receptor potential cation channel subfamily V member 1 (TRPV1) was observed by confocal laser scanning microscope (CLSM). IL-11 production from hPDL cells was measured using an ELISA, with or without AEA in the presence or absence of capsazepine, a selective TRPV1 antagonist AEA secreted into GCF was detected, but there was no correlation between the probing pocket depth (PPD) and AEA level. TRPV1 mRNA was detected in hPDL cells and the TRPV1 expression was observed by CLSM. IL-11 production from hPDL cells was significantly enhanced by AEA stimulation and this IL-11 production was suppressed by capsazepine. Our findings indicate that this endogenous cannabinoid system has a possible role in bone metabolism in periodontitis through TRPV1.
[Dental prostheses using fiberglass].
Takahashi H
Kokubyo Gakkai Zasshi · 2012 Mar · PMID 22568076
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[Analysis and classification of Latin anatomical names of skeletal fossa in Terminologia Anatomica, and comparison with corresponding Japanese anatomical names].
Shikano S, Abe T, Terashima T
Kokubyo Gakkai Zasshi · 2011 Oct · PMID 22187883
For a better understanding of the structures comprising the human body and in view of the possible need for future revision of anatomical nomenclature, Latin anatomical names of skeletal fossa in Terminologia Anatomica w...
For a better understanding of the structures comprising the human body and in view of the possible need for future revision of anatomical nomenclature, Latin anatomical names of skeletal fossa in Terminologia Anatomica were analyzed and classified, and compared with the corresponding Japanese anatomical names. The words following Fossa indicated: 1) the form of the fossa, 2) the structure to which the fossa belongs, 3) the position of the fossa, 4) the structure that exists near the fossa, 5) the structure that the fossa contains, 6) the structure attached to the fossa, 7) the structure that transmits the fossa, or 8) the structure with which the fossa articulates. The analysis of Latin names and comparison with Japanese names clarified some characteristics of both names and revealed some problems in them.
[The occlusal curvature and masticatory function].
Okano K
Kokubyo Gakkai Zasshi · 2011 Oct · PMID 22187882
This study examined the association between masticatory movement and occlusal curvature in dentate adults. Forty-six subjects (mean age : 25.0 years) with complete permanent dentition except for their third molars partic...
This study examined the association between masticatory movement and occlusal curvature in dentate adults. Forty-six subjects (mean age : 25.0 years) with complete permanent dentition except for their third molars participated in this study. A mandibular cast mounted on the lower member of an articulator was fixed to a three-dimensional measuring gauge (QM-Measure 353). Approximate spheres were calculated from the measurements according to the Broadrick Occlusal Plane Analyser. Subjects were asked to chew raw carrot, cheese, fish paste, boiled beef and gummy candy prepared to the size of 10 x 10 x 20 mm. Three-dimensional chewing movements of the mandibular central incisor point were measured using a Gnatho-analyzer. The Pearson correlation coefficient and multiple regression analysis were used to test the relationship between the occlusal curvature and masticatory movement. Significant correlations were found between masticatory movement and occlusal curvature in dentate adults (p < 0.01). Regression analysis found that subjects with larger occlusal curvature showed greater maximum velocity, larger vertical range and shorter cycle duration (p < 0.05). These results suggest that occlusal curvature is associated with masticatory movements.
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