Kokubyo Gakkai Zasshi. The Journal Of The Stomatological Society, Japan[JOURNAL]
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200 papers
[Detection of potentially malignant and malignant lesions of oral cavity using autofluorescence visualization device].
Matsumoto K
Kokubyo Gakkai Zasshi · 2011 Jun · PMID 21827020
Light-based oral cancer screening aids have been developed in identifying potentially malignant and malignant lesions of oral cavity at their earliest stage. The VELscope system is a simple hand-held device that facilita...
Light-based oral cancer screening aids have been developed in identifying potentially malignant and malignant lesions of oral cavity at their earliest stage. The VELscope system is a simple hand-held device that facilitates the direct visualization of oral-cavity fluorescence for the detection of precancerous and cancerous lesions. Some published reports have shown that this system can assist in the detection of precancerous and cancerous lesions, but there is no evidence that it can distinguish between them. We studied whether objective discrimination criteria can be set for this system when observing oral mucosal lesions. We examined 74 cases with biopsy-confirmed oral mucosal lesions; 37 squamous cell carcinoma lesions, 14 moderate to severe epithelial dysplasia lesions, 13 mild epithelial dysplasia lesions and 10 lichen planus lesions. Lesions were examined macroscopically under the conventional overhead light, and then, examined by this device. Each examination was recorded with a digital camera. We contrasted findings with histopathological manifestation, and calculated the attenuation score. It is found that several conditions and sites, such as keratinization and the degree of inflammatory cell infiltration, were associated with detection sensitivity using this device. Based on the attenuation scores, a significant difference was seen between squamous cell carcinoma and epithelial dysplasia. It is suggested that this device might be a valuable adjunct in the early detection of potentially malignant and malignant lesions of the oral cavity.
[An opinion of preventive oral health care].
Shinada K
Kokubyo Gakkai Zasshi · 2011 Jun · PMID 21827019
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[Economic effects of single-pack dental hygienic materials introduced into daily clinical practice].
Sunakawa M, Matsumoto H, Izumi Y
Kokubyo Gakkai Zasshi · 2011 Mar · PMID 21560660
To improve and maintain medical safety and quality, it is necessary to construct and manage a safe and economical medical system. Almost five years have passed since single-pack dental hygienic materials were introduced...
To improve and maintain medical safety and quality, it is necessary to construct and manage a safe and economical medical system. Almost five years have passed since single-pack dental hygienic materials were introduced into daily clinical practice in the University Hospital, Faculty of Dentistry, Tokyo Medical and Dental University. The costs of purchasing hygienic materials themselves are higher when using outsourced sterilized single packed ones, compared with when using intra-murally sterilized ones in the past. Proper usage of single-pack hygienic materials sterilized with Ethylene Oxide Gas (EOG) would reduce waste of unused materials and save labor for staff in the Section of Central Supplies. Financially, the use of hygienic materials could be reduced if single-pack dental hygienic materials by outsourcing were introduced into the hospital, because all costs for sterilizing hygienic materials in the hospital could be eliminated.
[A clinico-pathological study of 20 cases of Warthin's tumors of the parotid gland].
Ishii J, Kinoshita K, Mochizuki M … +2 more , Amagasa T, Okada N
Kokubyo Gakkai Zasshi · 2011 Mar · PMID 21560659
PURPOSE: The purpose of this study was to clarify the clinico-pathological findings of Warthin's tumors. SUBJECTS AND METHODS: Twenty cases of Warthin's tumors treated at our clinic during the past 22 years and their med...
PURPOSE: The purpose of this study was to clarify the clinico-pathological findings of Warthin's tumors. SUBJECTS AND METHODS: Twenty cases of Warthin's tumors treated at our clinic during the past 22 years and their medical charts and imaging films were reviewed. RESULTS: Warthin's tumors occurred more frequently in middle-aged or elderly men than in women. Solitary tumors were significantly larger (p < 0.05) than multiple tumors. Warthin's tumors that accumulated 99mTc were significantly larger (p < 0.05) than those that did not. In addition, there was no difference in clinical findings between the two histopathologic types of Warthin's tumors. CONCLUSION: The frequent occurrence of multiple Warthin's tumors indicated the importance of an accurate clinical and radiological examination of parotid glands, in order to detect possible multiple lesions prior to treatment.
[An analysis of stress around abutment teeth and periodontium in three-unit fixed partial dentures--photoelastic analysis with simulated periodontal ligament].
Yusa K
Kokubyo Gakkai Zasshi · 2011 Mar · PMID 21560658
The mechanical characteristics of zirconia, hybrid hard resin and dental metal for crowns and fixed partial dentures (FPD) have been researched for clinical applications. However, for these kinds of restorations, the dis...
The mechanical characteristics of zirconia, hybrid hard resin and dental metal for crowns and fixed partial dentures (FPD) have been researched for clinical applications. However, for these kinds of restorations, the distribution of mechanical stress around the abutment teeth and periodontium during function has not been sufficiently assessed. The aim of this study was to clarify the influence of these materials upon abutment teeth and periodontium through a two-dimensional photoelastic method. Two-dimensional simulation models of three-unit FPDs were constructed from these materials. By applying a force of 400 N vertically to these FPDs, the stress distribution around the abutment teeth and alveolar bone was analyzed and the fringe orders were recorded with a transmission polariscope. As a result, the fringe order values at the root dentin around the marginal area of the pontic joint were the highest in zirconia, and the smallest in hybrid hard resin. The spread of internal stress around the marginal area was larger in the hybrid hard resin model and dental metal model than in the zirconia model. This study suggested that differences in stress distribution within the abutment teeth and around the alveolar bone were related to differences in elastic coefficients of the materials used in FPDs.
[Expression analysis of EGFR and SGLT1 in oral squamous cell carcinoma].
Hanabata Y
Kokubyo Gakkai Zasshi · 2011 Mar · PMID 21560657
Overexpression of epidermal growth factor receptor (EGFR) is known to be associated with poor prognosis in malignant tumors. Sodium-glucose co-transporter 1 (SGLT1) is a membrane protein that transports glucose across ce...
Overexpression of epidermal growth factor receptor (EGFR) is known to be associated with poor prognosis in malignant tumors. Sodium-glucose co-transporter 1 (SGLT1) is a membrane protein that transports glucose across cellular membranes. Recently, EGFR has been shown to stabilize SGLT1 and promote glucose uptake into cancer cells. The purpose of this study was to investigate the coexpression of EGFR and SGLT1 and their relationships with clinicopathological features in oral squamous cell carcinoma (OSCC). Total cell lysates from OSCC cell lines were prepared to check the protein expression of EGFR and SGLT1 by western blotting assay. Both proteins can be detected and the expression levels of SGLT1 were significantly correlated with those of EGFR. Pearson's product-moment correlation coefficient was 0.89 (p = 0.016). Transient overexpression of EGFR in HeLa cells showed that SGLT1 expression was increased by EGFR, suggesting that EGFR can stabilize the protein stability of SGLT1. To see whether mRNA expression of SGLT1 is correlated with protein expression, real-time PCR was performed. The results revealed no compatible expression between mRNA and protein, indicating that this discrepancy is caused by the post-transcriptional modification. Immunohistochemical staining using surgical specimens from 52 tongue SCC patients also showed a significant correlation between EGFR and SGLT1 expression. Moreover, EGFR/SGLT1 expression was inversely correlated with tumor differentiation (p = 0.004). These results indicate that EGFR/SGLT1 coexpression may contribute to the growth and survival of OSCC, but further study is needed to clarify the implication of these proteins in the manifestation of malignancy and clinical significance.
[The effect of oral care on natural immune function in the dependent elderly].
Yamada C, Kubota C, Uematsu H
Kokubyo Gakkai Zasshi · 2011 Mar · PMID 21560656
While oral care is known to play an important role in the prevention of aspiration pneumonia, its influence on immune function is unclear. In this study, we performed oral care on ten dependent elderly individuals and ex...
While oral care is known to play an important role in the prevention of aspiration pneumonia, its influence on immune function is unclear. In this study, we performed oral care on ten dependent elderly individuals and examined its influence on NK cell activity. The study duration was 12 weeks. During the first six weeks, the subjects cleaned their mouths as usual (control period). In the last six weeks, a dental hygienist performed oral care and denture cleaning three times a week (intervention period). The outcome measure was the quantity of oral bacteria and the detection rate of the microbe in connection with an opportunistic infection and NK cell activity before and after the intervention. Samples were collected at three time points: the beginning of the study, after the control period and before the intervention period (i. e., after six weeks), and after the intervention period (i. e., after 12 weeks). There was no significant difference in the number of oral bacteria between the control period and the intervention period. In contrast, while NK cell activity did not change during the control period, activity increased during the intervention period (p = 0.03). This finding suggests that rather than decreasing the number of oral bacteria, oral care increases NK cell activity.
[Neural mechanisms for navigation].
Taira M
Kokubyo Gakkai Zasshi · 2011 Mar · PMID 21560655
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[Analysis and classification of Latin anatomical names of skeletal canals in Terminologia anatomica, and comparison with corresponding Japanese anatomical names].
Shikano S, Abe T, Terashima T
Kokubyo Gakkai Zasshi · 2010 Oct · PMID 21114011
For a better understanding of the structures comprising the human body and in view of the possible need for future revision of anatomical nomenclature, Latin anatomical names of skeletal canals (including canaliculi) in...
For a better understanding of the structures comprising the human body and in view of the possible need for future revision of anatomical nomenclature, Latin anatomical names of skeletal canals (including canaliculi) in Terminologia Anatomica were analyzed and classified, and compared with the corresponding Japanese anatomical names. The words following Canalis or Canales indicated: (1) the structure to which the canal belongs, (2) the structure to which the opening of the canal belongs, (3) the position of the canal, (4) the structure to which the canal leads, (5) the structure that exists near the opening of the canal, (6) the structure that transmits the canal, (7) the structure that is a component of the canal, or (8) the function of the canal. The analysis of Latin names and comparison with Japanese names clarified some characteristics of both names and revealed some problems in them.
[Researches for improving local anesthesia method in dentistry].
Fukayama H
Kokubyo Gakkai Zasshi · 2010 Oct · PMID 21114010
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[The significance of tongue function in occlusal dysfunction].
Ono T
Kokubyo Gakkai Zasshi · 2010 Oct · PMID 21114009
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[A colorimetric study of pigmented lesions on oral mucosa].
Suzuki M
Kokubyo Gakkai Zasshi · 2010 Jun · PMID 20662308
The purpose of this study is to state the clinical and colorimetric features of pigmented lesions on oral mucosa. Among 201 pigmented lesions on oral mucosa, there were 74 melanin pigmentations (36.9%), 72 exogenous pigm...
The purpose of this study is to state the clinical and colorimetric features of pigmented lesions on oral mucosa. Among 201 pigmented lesions on oral mucosa, there were 74 melanin pigmentations (36.9%), 72 exogenous pigmentations (35.8%), 28 pigmented nevi (13.9%), and 27 malignant melanomas (13.4%). Melanin pigmentations were found mainly on the gingiva and lip, exogenous pigmentations were on the gingiva, pigmented nevi were found on the buccal mucosa, and malignant melanomas were on the upper gingiva. Thirty-six pigmented lesions were measured by colorimeter, and each lesion was evaluated numerically using the CIE L*a*b* colorimetric system. The statistical significance was confirmed by Tukey's test and a p value <0.05 was assumed as a significant difference. The color distribution of melanin pigmentation and exogenous pigmentation and malignant melanoma were significantly lower than normal mucosa in L*. A statistical significance was found between each pigmented lesion and normal mucosa in a* and b*. Among malignant melanoma and melanin pigmentation or exogenous pigmentation, a statistical significance was found in a* and b*. The color difference between melanin pigmentation and malignant melanoma was significant. The color distribution is thought to be different in each pigmented lesion, and we suggest that it is useful to use colorimetric features to diagnose each pigmented lesion.
[Association between phenytoin-induced gingival hyperplasia and periodontopathic bacteria in institutionalized patients with severe motor and intellectual disabilities].
Miyazaki H
Kokubyo Gakkai Zasshi · 2010 Jun · PMID 20662307
The association between phenytoin-induced gingival hyperplasia (PIGH) and five major periodontopathic bacteria was investigated by real-time PCR in 12 subjects (30.6 +/- 7.95 years of age) with severe motor and intellect...
The association between phenytoin-induced gingival hyperplasia (PIGH) and five major periodontopathic bacteria was investigated by real-time PCR in 12 subjects (30.6 +/- 7.95 years of age) with severe motor and intellectual disabilities. The subjects had not received antibiotics or periodontal therapy within three months. A healthy gingival site or a site with the lowest gingival hyperplasia score (minimum site), and a site with the maximum score of gingival hyperplasia (maximum site) on each subject were selected for investigation. The clinical parameters were measured after microbial sampling. The following results were obtained: 1. The detection rates of both Treponema denticola and Porphyromonas gingivalis were 75% (9/12) at the maximum sites, and that of Tannerella forsythia was 33.3% (4/12). The detection rate of Prevotella intermedia was 58.3% (7/12), but no significant correlation was observed between this bacterium and the other types of bacteria in quantitative analysis. 2. The detection rate of P. gingivalis with type II fimA was 25% (1/4) at the minimum sites, and 83.3% (5/6) at the maximum sites. 3. The samples were divided into three groups; namely, those with no detection of P. gingivalis at either the minimum sites or the maximum sites, no detection at the minimum sites but detection at the maximum sites, and detection at both sites. In conclusion, 1) the detection rates of T. denticola and P. gingivalis were the highest at the maximum sites. In particular, the detection rate of P. gingivalis with type II fimA was high in the present study, and 2) the subgingival microflora was diverse because of the diverse severity of gingival inflammation associated with PIGH.
[Three-dimensional analysis of the morphology of philtrum and philtral dimple of unilateral cleft lip/cleft lip and palate patients before and after secondary cleft lip and nose repair].
Mishimagi T
Kokubyo Gakkai Zasshi · 2010 Jun · PMID 20662306
The purpose of this study is to measure the morphology of the nose and lip of unilateral cleft lip/cleft lip and palate (UCL/UCLP) patients with a three-dimensional (3-D) digitizer before and after secondary cleft lip an...
The purpose of this study is to measure the morphology of the nose and lip of unilateral cleft lip/cleft lip and palate (UCL/UCLP) patients with a three-dimensional (3-D) digitizer before and after secondary cleft lip and nose repair, and to compare them with normal adults, as well as to investigate the effectiveness of philtrum plastic surgery. This study includes 21 UCL/CLP patients who received the same operation. We used 12 normal adults as the control group. We took facial impressions at the time of pre-operation and six months after operation, and constructed the models using hard plaster. These plaster casts were used as materials in this study. The control materials were also made from normal adults in the same manner. All the measurements were taken using calipers and the depth of the philtral dimple was measured with a 3-D digitizer. The distance between the inside of the eye and the alar base, the distance between the bilateral alar bases, the distance between the columella base and the alar base were measured. The length of philtrum ridge showed obvious signs of improvement, and was almost the same as normal adults after our surgical approach. The width of the philtrum and the depth of the philtral dimple of UCL/CLP patients were improved after secondary cleft lip and nose repair. However, further treatment is still essential for better aesthetics and recovery.
[Development of low-concentration hydrogen peroxide whitening agent using visible light-responsive titania photocatalyst].
Arai H
Kokubyo Gakkai Zasshi · 2010 Jun · PMID 20662305
Although highly concentrated hydrogen peroxide (HP) has been used to bleach vital discolored teeth during office whitening, low-concentration HP was recognized to have insufficient whitening ability. We demonstrated that...
Although highly concentrated hydrogen peroxide (HP) has been used to bleach vital discolored teeth during office whitening, low-concentration HP was recognized to have insufficient whitening ability. We demonstrated that using a visible light-responsive titania photocatalyst (VLRTP) and a vis-Nd : YAG laser, 3 wt% HP-bleached oxytetracycline (OTC)-stained teeth models were more efficient than 30 wt% HP. The stained samples were prepared by soaking synthetic hydroxyapatite ceramic disks in OTC aqueous solutions. Color images of the OTC-stained models before and after whitening were taken with a conventional flatbed scanner and calibrated using a photocell colorimeter. By VLRTP treatment with vis-Nd : YAG laser irradiation, the lightness value (L*) significantly increased and the yellowness index (b*) significantly approached zero. This suggests that a diluted HP agent with VLRTP can more efficiently decolorize stained teeth by visible light irradiation.
[Effects of pulpal inflammation on the activities of periodontal mechanoreceptive afferent fibers].
Matsumoto H
Kokubyo Gakkai Zasshi · 2010 Jun · PMID 20662304
Response properties of periodontal single afferents were investigated in cats with inflammatory irritant-induced pulpitis. A deep dentin cavity was prepared on the right mandibular canine in order to apply an inflammator...
Response properties of periodontal single afferents were investigated in cats with inflammatory irritant-induced pulpitis. A deep dentin cavity was prepared on the right mandibular canine in order to apply an inflammatory agent and small fiber excitant, allyl-isothiocyanate (mustard oil: MO), and single afferents innervating the canine periodontal mechanoreceptor were dissected from the mandibular nerve bundle by examining impulse responses while applying mechanical stimuli to the tip of the crown. Evoked impulses by mechanical stimuli were increased in number for 15 minutes with MO application to the pulp when compared with those with mineral oil. The mechanoreceptive thresholds of single nerve fibers were decreased after the MO application to the pulp when compared with those with mineral oil. These results suggest that the alteration of responses in the periodontal afferent fiber, or the peripheral sensitization, can be produced by MO-induced pulpal inflammation probably due to the axon reflex mechanism in the furcating branches of nerve fibers innervating both the tooth pulp and periodontal ligament.
[Photoelastic stress analysis of root dentin with different composite resin post and core systems and crowns].
Takei H
Kokubyo Gakkai Zasshi · 2010 Mar · PMID 20415253
Much research has been reported about post and core systems with composite resin, but the influence of the different types of prefabricated posts on the distribution of stress in the root has not yet been elucidated. It...
Much research has been reported about post and core systems with composite resin, but the influence of the different types of prefabricated posts on the distribution of stress in the root has not yet been elucidated. It is necessary to clarify the influence of the relationship between core and crown materials to obtain combined restorations. The aim of this study is to analyze the influence of the combination of various post and core systems and different kinds of crown material on the stress distribution in the root. Six 2-dimensional photoelastic premolar models were designed. Three types of post and core systems (composite resin post and core, composite resin core with the fiber post, and composite resin core with a prefabricated stainless steel post) and two kinds of crown materials (metal and hybrid-type hard composite resin) were fabricated and cemented to each model. In these models, we applied a load of 200 N at an angle of 45 degrees to the tooth axis and analyzed the fringe order using a transmission polariscope. As a result, it has been clarified that the combination of the post and core and the crown plays an important role in preventing stress concentration within root Stress concentration can be prevented using a crown fabricated with a high-elastic modulus for the post and core with a high-elastic modulus, and a crown fabricated with a low-elastic modulus for the post and core with a low-elastic modulus.
[Influence of the design of zirconia framework on the fracture strength of veneering porcelain].
Mori K
Kokubyo Gakkai Zasshi · 2010 Mar · PMID 20415252
Recently, new metal free materials for crown and bridges such as yttria stabilized tetragonal zirconia polycrystals (Y-TZP) have been introduced in the dental profession. These systems enable the fabrication of long-span...
Recently, new metal free materials for crown and bridges such as yttria stabilized tetragonal zirconia polycrystals (Y-TZP) have been introduced in the dental profession. These systems enable the fabrication of long-span bridges of more than 3 units in the posterior region. But occasionally chipping of the veneering porcelain was observed. The aim of this study was to analyze the influence of the design of the zirconia framework on the fracture strength of the veneering porcelain. Two types of Y-TZP framework were fabricated for the lower second premolar crown (normal type and support type) (Cercon base colored, DeguDent, Hanau-Wolfgang, Germany). The support-type framework has a 1 mm-wide collar around the margin to support the veneering porcelain. Twelve all-ceramic crowns were fabricated, six crowns for each group. The framework was covered by veneering ceramics (Vintage ZR Press Over, SHOFU INC., Kyoto, Japan) using the heat press method. All specimens were fixed using adhesive resin cement on the master die and the vertically loaded was measured at the distal ridge of the crown at a cross-head speed of 1 mm/min until fracture. The maximum compressive load required to cause a fracture was recorded for each specimen. The t test was used for the statistical analysis of the fracture loads, with a significance level of alpha = 0.05. The following conclusion was obtained. The fracture strength of the all-ceramic crowns with a support-type Y-TZP framework was significantly higher than that of the normal type. This result suggests that the design of the Y-TZP framework is important for all-ceramic restorations.
[Advance notice of contents of treatment influences patients' stress during dental treatment].
Ozaki T
Kokubyo Gakkai Zasshi · 2010 Mar · PMID 20415251
The purpose of this study is to clarify the effect of advance notice of contents of treatment on the patients' physiological stress during dental treatment The subjects of our study comprised 34 non-dental professionals...
The purpose of this study is to clarify the effect of advance notice of contents of treatment on the patients' physiological stress during dental treatment The subjects of our study comprised 34 non-dental professionals (22 female and 12 male). In simulated dental treatment, the subjects were exposed to predetermined stimulations comprised of blowing air on the molars, percussion on the premolar and usage of an air turbine next to the molar in randomized order, with/without advance notice. The skin potential level (SPL) of the subjects was measured as a physiological stress index during such simulated dental treatment As a psychological profile, the stress-coping style of each subject was examined using Lazarus Type Stress Coping Inventory (SCI). The number of decayed, missing, filled teeth (DMF). and the experience of teeth extraction in the past of each subject was also recorded. The correlation among advance notice, order and kind of stimulation, factors of SCI, DMF, gender of the subject, the experience of teeth extraction, and the subjects' stress (SPL change) was statistically analyzed using the generalized estimating equation. As a result, the effect of advance notice on the subjects' stress was opposite when the stress-coping style differed; therefore, dentists must pay attention to the patients' psychological characteristics when using advance notice for the purpose of relieving the patients' stress during dental treatment.
[Influence of a liquid diet on the jaw-closing muscle spindles in growing rats].
Shibata M
Kokubyo Gakkai Zasshi · 2010 Mar · PMID 20415250
Recently, it has been shown that prolonged feeding of a liquid diet after being weaned impedes the functional development and leads to immature mastication in growing rats. Since the jaw muscle spindles play an important...
Recently, it has been shown that prolonged feeding of a liquid diet after being weaned impedes the functional development and leads to immature mastication in growing rats. Since the jaw muscle spindles play an important role in the control of the jaw movement during the normal masticatory function, in this study we investigated the effects of prolonged feeding of a liquid diet after being weaned on the functional development of the jaw-closing muscle spindles in growing rats. Soon after weaning, 40 female Wistar rats were divided into two equal groups. The control group was fed a solid diet and the experimental group was fed a liquid diet. At 5, 7, 9 and 11 weeks, the rats were anesthetized and the response of the masseter muscle spindles to ramp-and-hold jaw stretches were recorded from the mesencephalic trigeminal nucleus. In the experimental groups, both the dynamic and the static indices were significantly lower than those of the control groups at the age of 5, 7, 9 and 11 weeks old. There was no significant change within the same group during the experimental period in both indices. These results suggest that the long-term masticatory functional change due to feeding of a liquid diet may impede the maturation of the functional properties of the jaw-closing muscle spindles, leading to immature mastication in growing rats.
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