Experimental Aging Research[JOURNAL]
Sun
200 papers
Hippocampal Subregions Volume and Texture for the Diagnosis of Mild Cognitive Impairment.
Chu T, Liu Y, Gui B … +5 more , Zhang Z, Zhang G, Dong F, Dong J, Lin S
Exp Aging Res · 2025 · PMID 38357913 · Publisher ↗
The aim was to examine the diagnostic efficacy of hippocampal subregions volume and texture in differentiating amnestic mild cognitive impairment (MCI) from normal aging changes. Ninety MCI subjects and eighty-eight well...
The aim was to examine the diagnostic efficacy of hippocampal subregions volume and texture in differentiating amnestic mild cognitive impairment (MCI) from normal aging changes. Ninety MCI subjects and eighty-eight well-matched healthy controls (HCs) were selected. Twelve hippocampal subregions volume and texture features were extracted using Freesurfer and MaZda based on T1 weighted MRI. Then, two-sample t-test and Least Absolute Shrinkage and Selection Operator (LASSO) regression were developed to select a subset of the original features. Support vector machine (SVM) was used to perform the classification task and the area under the curve (AUC), sensitivity, specificity and accuracy were calculated to evaluate the diagnostic efficacy of the model. The volume features with high discriminative power were mainly located in the bilateral CA1 and CA4, while texture feature were gray-level non-uniformity, run length non-uniformity and fraction. Our model based on hippocampal subregions volume and texture features achieved better classification performance with an AUC of 0.90. The volume and texture of hippocampal subregions can be utilized for the diagnosis of MCI. Moreover, we found that the features that contributed most to the model were mainly textural features, followed by volume. These results may guide future studies using structural scans to classify patients with MCI.
Examining the Utility of a Multiple Group Membership Intervention for Alleviating the Effects of Age-Based Stereotype Threat on Older adults' Memory Performance.
Parker GJ, Haslam C, Stuart J … +2 more , Shum DHK, Ownsworth T
Exp Aging Res · 2025 · PMID 38278144 · Publisher ↗
This study examined the effectiveness of a multiple group membership intervention for reducing the negative effects of age-based stereotype threat (ABST) on older adults' objective memory performance and subjective memor...
This study examined the effectiveness of a multiple group membership intervention for reducing the negative effects of age-based stereotype threat (ABST) on older adults' objective memory performance and subjective memory concerns. Healthy older adults ( = 68) were randomly allocated to an ABST + threat-removal (ABST+TR) or ABST + active-control (ABST+AC) condition. After activating ABST, the ABST+TR condition completed a group-listing task and the ABST+AC condition completed a meal-listing task. Participants then completed the Rey Auditory Verbal Learning Test (RAVLT) and Everyday Memory Questionnaire - Revised. One significant difference was found in memory performance between conditions; specifically, after controlling for age, gender, and number of items listed, those in the ABST+TR condition performed significantly better on the RAVLT memory interference trial. Further, listing a greater number of group memberships was associated with better memory performance in the ABST+TR condition. No significant difference was found in subjective memory concerns between the ABST+TR condition and the ABST+AC condition. Overall, the current findings indicated that raising the salience of multiple group memberships offered limited protection for older adults' cognitive test performance in the context of ABST.
Music-Evoked Autobiographical Memories are Associated with Negative Affect in Younger and Older Adults.
Mehl K, Reschke-Hernandez AE, Hanson J … +7 more , Linhardt L, Frame J, Dew M, Kickbusch E, Johnson C, Bai E, Belfi AM
Exp Aging Res · 2025 · PMID 38217422 · Full text
BACKGROUND: Music evokes strong and persistent emotional responses. However, the mechanisms underlying the emotional effects of music, particularly in older adults, are largely unknown. One purported mechanism by which m...
BACKGROUND: Music evokes strong and persistent emotional responses. However, the mechanisms underlying the emotional effects of music, particularly in older adults, are largely unknown. One purported mechanism by which music evokes emotions is through memory - that is, music evokes personal, autobiographical memories that then lead to emotional responses. METHOD: Here, we investigated whether memory-evoking music induces stronger and longer-lasting emotional responses than non-memory-evoking music, and whether these emotional responses differ between younger and older adults. Older (N = 30) and younger adults (N =30) listened to two blocks of self-selected music (one block of memory-evoking music and one block of familiar but non-memory-evoking music). Participants reported their emotions prior to and at three timepoints post-listening. RESULTS: Older adults reported higher levels of positive affect than younger adults. For both groups, positive affect increased after listening to both memory-evoking and non-memory-evoking music. However, negative affect only increased after listening to memory-evoking music. CONCLUSIONS: These results suggest that both memory-evoking and non-memory-evoking music generate strong emotions in younger and older adults, but music that conjures personal memories is more likely to elicit mixed emotions. Our results have important clinical implications when designing music-based interventions for mood and affect, particularly in older adult populations.
The Effect of Central Sensitization on Postoperative Neurocognitive Dysfunction in Hospitalized Elderly Patients: A Prospective Cohort Clinical Trial.
Yu L, Yang D, Zhou Q … +5 more , Yin C, Zhang Q, Li W, Yu J, Wang Q
Exp Aging Res · 2024 · PMID 38192192 · Publisher ↗
OBJECTIVE: To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD). METHODS: One hundred and thirty-three aged patients under...
OBJECTIVE: To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD). METHODS: One hundred and thirty-three aged patients undergoing total knee arthroplasty (TKA) who received femoral nerve block and general anesthesia were recruited in this research and prospectively assigned into two groups according to the Central Sensitization Inventory (CSI) score: group C ( = 106, CSI score less than 40) and group CS ( = 27, CSI score higher than 40). Scores of Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM), Numerical Rating Scale (NRS) and Quality of recovery-40 (QoR-40) questionnaires were assessed. Basic information and clinical records of all participants were also collected. RESULTS: PNCD occurred in 24 (22.6%) of patients in group C and 16 (59.3%) in group CS ( < .05). Multivariate logistic regression analysis revealed that patients with CSI score ≥40 before surgery exhibited higher risk of PNCD after adjustment for other risk factors ( < .05). Compared to group C, the pre- and post-operative NRS scores, pain duration, the WOMAC score, and propofol consumptions for anesthesia induction were significantly increased in group CS ( < .05). CONCLUSION: Hospitalized elderly patients with clinical symptoms of CS scores may have increased risk of PNCD following TKA.
Lack of Interaction Motivation in Older Adults Automatically Reduces Cognitive Empathy.
Sun B, Luo Z, Zhu X … +5 more , Shao Y, Zhang W, Qin G, Lin S, Wan S
Exp Aging Res · 2024 · PMID 38192191 · Publisher ↗
Empathy, the ability to understand and respond to the experiences of others, is an important skill for maintaining good relationships throughout one's life. Previous research indicated that emotional empathy remained sta...
Empathy, the ability to understand and respond to the experiences of others, is an important skill for maintaining good relationships throughout one's life. Previous research indicated that emotional empathy remained stable or even increased in older adults compared to younger adults, while cognitive empathy showed age-related deficits. Based on the selective engagement hypothesis, this deficit was not caused by a decline in cognitive functioning, but by a lack of willingness to judge the target person's emotions more precisely, that is, by a lack of interaction motivation. In order to provide more evidence on the causes of empathic aging in older adults, the current study investigated the influence of interaction motivation on empathy in older adults in an Eastern cultural context (China) based on the selective engagement hypothesis. This study used older adults and younger adults as subjects. Through two experiments, empathy was measured by the multiple empathy test (Experiment 1) and film tasks (Experiment 2); at the same time, use accountability instructions (Experiment 1), the age-related events (Experiment 2) to manipulate interaction motivation. The results showed that emotional empathy was significantly higher in older adults than in younger adults, regardless of whether interaction motivation was elicited. In terms of cognitive empathy, when there is no motivation, the cognitive empathy of older adults is significantly lower than that of younger adults. When the interaction motivation is stimulated, the cognitive empathy of older adults is no less than that of younger adults. This suggested that empathic aging in older adults was not a permanent decline in cognitive empathy, but rather a decline in interaction motivation, supporting the selective engagement hypothesis.
Exposure to Memory-Relevant versus Memory-Irrelevant Aging Stereotypes Differentially Affects Memory Self-Perceptions and Memory Test Scores of Young, Middle, and Older Age Adults.
Lineweaver TT, Wetli AC, Nicoson C … +2 more , Tucker AJ, Hertzog C
Exp Aging Res · 2025 · PMID 38126198 · Publisher ↗
This study examined the combined influence of assimilation and contrast effects on the memory self-efficacy and objective memory of young (ages 18-25, = 114), middle-age (ages 26-59, = 48), and older (ages 60-98, = 59...
This study examined the combined influence of assimilation and contrast effects on the memory self-efficacy and objective memory of young (ages 18-25, = 114), middle-age (ages 26-59, = 48), and older (ages 60-98, = 59) adults. We reminded participants that they matched positive, not negative, memory-relevant or memory-irrelevant stereotypes of aging either before (experimental conditions) or after (control condition) they completed a memory self-efficacy questionnaire and took a memory test. Participants exposed to memory-relevant aging stereotypes prior to other measures reported higher memory self-efficacy than those exposed to memory-irrelevant stereotypes; this effect did not depend on age group. In contrast, the effect of stereotype exposure on memory performance differed with age. Young and older, but not middle-aged, adults showed differences in their memory scores depending on whether they were exposed to memory-relevant, memory-irrelevant or no aging stereotypes. In general, exposure to stereotypes (particularly those relevant to memory) had a negative influence on memory that contrasted with its positive effect on memory self-efficacy. Together, these results indicate that exposure to aging stereotypes can have opposing effects on the memory self-efficacy and objective test performance of adults of various ages and that the relevance of the stereotypes to the cognitive domain being assessed matters.
Congruent Prosody Reduces Cognitive Effort in Memory for Spoken Sentences: A Pupillometric Study with Young and Older Adults.
O'Leary RM, Amichetti NM, Brown Z … +2 more , Kinney AJ, Wingfield A
Exp Aging Res · 2025 · PMID 38061985 · Publisher ↗
BACKGROUND: In spite of declines in working memory and other processes, older adults generally maintain good ability to understand and remember spoken sentences. In part this is due to preserved knowledge of linguistic r...
BACKGROUND: In spite of declines in working memory and other processes, older adults generally maintain good ability to understand and remember spoken sentences. In part this is due to preserved knowledge of linguistic rules and their implementation. Largely overlooked, however, is the support older adults may gain from the presence of sentence prosody (pitch contour, lexical stress, intra-and inter-word timing) as an aid to detecting the structure of a heard sentence. METHODS: Twenty-four young and 24 older adults recalled recorded sentences in which the sentence prosody corresponded to the clausal structure of the sentence, when the prosody was in conflict with this structure, or when there was reduced prosody uninformative with regard to the clausal structure. Pupil size was concurrently recorded as a measure of processing effort. RESULTS: Both young and older adults' recall accuracy was superior for sentences heard with supportive prosody than for sentences with uninformative prosody or for sentences in which the prosodic marking and causal structure were in conflict. The measurement of pupil dilation suggested that the task was generally more effortful for the older adults, but with both groups showing a similar pattern of effort-reducing effects of supportive prosody. CONCLUSIONS: Results demonstrate the influence of prosody on young and older adults' ability to recall accurately multi-clause sentences, and the significant role effective prosody may play in preserving processing effort.
COPD, Dietary Fiber Intake, and Cognitive Performance in Older Adults: A Cross-Sectional Study from NHANES 2011-2014.
Liang S, Han X, Diao S … +1 more , Li H
Exp Aging Res · 2025 · PMID 38012841 · Publisher ↗
INTRODUCTION: This study aimed to evaluate the modifying role of dietary fiber intake in the relationship between COPD and cognitive performance. METHODS: Data of adults aged ≥60 years were extracted from the National He...
INTRODUCTION: This study aimed to evaluate the modifying role of dietary fiber intake in the relationship between COPD and cognitive performance. METHODS: Data of adults aged ≥60 years were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Participants with information on cognitive function measures were included. Dietary fiber intake, identified using participants' 24-h recall surveys, was grouped into high (>25 g/day) and low (≤25 g/day) levels. COPD was identified through self-reported physician diagnoses. Associations between dietary fiber intake, cognitive function and COPD were evaluated using the regression analysis. RESULTS: Data of 2,189 participants were analyzed. Multivariate analysis revealed that COPD was significantly associated with lowered CERAD (adjusted beta [aBeta]: -0.17, 95% confidence interval [CI]: -0.33 to -0.002, = .047) and DSST (aBeta: -2.23, 95% CI: -4.25 to -0.2, = .032) scores in older adults. The analysis on the association between COPD and cognitive function stratified by dietary fiber intake revealed that COPD remained significantly associated with lowered CREAD among individuals with a high fiber intake (aBeta: -0.54, 95% CI: -1.00 to -0.08, = .024). CONCLUSIONS: In US older adults, COPD is associated with reduced cognitive function. However, the findings do not support that high dietary fiber intake may modify the association between COPD and cognitive impairment.
The Relationship Between Quality of Life and Depressive Symptoms Among Jordanian Community-Dwelling Older Adults.
Malak MZ, Khalifeh AH
Exp Aging Res · 2025 · PMID 37990905 · Publisher ↗
OBJECTIVE: The current study aimed to examine the relationship between depressive symptoms and quality of life among Jordanian community-dwelling older adults. METHODS: A cross-sectional, descriptive correlational design...
OBJECTIVE: The current study aimed to examine the relationship between depressive symptoms and quality of life among Jordanian community-dwelling older adults. METHODS: A cross-sectional, descriptive correlational design was used. A convenience sample ( = 602) was selected to recruit the participants in the Amman governorate during the period from August to November 2021. RESULTS: Findings demonstrated that the mean (SD) age of older adults was 67.5 (7.0) years and 51.5% of participants were females. Also, 54.1% of the participants experienced moderate to severe depressive symptoms with a total mean (SD) score was 8.57 on a scale of 0 to 15, while the mean (SD) for the quality of life scale was 12.12 (3.85) on a scale of 4 to 20. Significant differences existed in quality of life and depressive symptoms based on marital status ( < .001), educational level ( < .001), working status ( < .01), income ( < .001), and chronic disease ( < .01). Quality of life and its domains were negatively associated with depressive symptoms (B= - 0.596, < .001). Also, marital status, working, educational level, income, and chronic disease were associated with depressive symptoms. CONCLUSION: Strategies to improve quality of life should be promoted to minimize depressive symptoms among older adults and consider significant demographic factors.
The Effects of Vitamin D on Movement and Cognitive Function in Senile Mice After Sevoflurane Anaesthesia.
Zhang J, Zhang X, Zhao J … +1 more , Wu J
Exp Aging Res · 2024 · PMID 37990880 · Publisher ↗
BACKGROUND: Vitamin D (VD) is a neuroactive steroid involved in many brain functions, such as neurotrophic, neuroimmune control and neurotransmission, which affects the growth and function of the brain. The purpose of th...
BACKGROUND: Vitamin D (VD) is a neuroactive steroid involved in many brain functions, such as neurotrophic, neuroimmune control and neurotransmission, which affects the growth and function of the brain. The purpose of this study is to explore the effect of VD on motor and cognitive function of aged mice after sevoflurane anesthesia. METHOD: We established sevoflurane anesthesia model and VD(-) and VD(+) mice model. The VD concentration of mice in each group was determined by enzyme-linked immunosorbent assay (ELISA). An open-field test was used to evaluate the mice's capacity for movement and exploration. A Y-maze test was used to gauge the mice's short-term memory. The primary purpose of the water-maze experiment was to examine mice's long-term spatial memory. RESULTS: The ELISA results showed that the model was successfully constructed. In the open-field test, VD increased the exercise distance of mice ( < .05). In the Y-maze experiment, VD improved short-term memory impairment in mice ( < .05). In the water-maze test, VD increased the activity time and platform crossing number of mice in the target quadrant. ( < .05). CONCLUSION: Sevoflurane anesthesia caused cognitive dysfunction in aged mice, including reduced learning ability, memory loss, lower motor and exploratory abilities and depression, and VD deficiency aggravated these impairments. By supplementing with VD, learning ability and long-term memory were enhanced, motor and exploratory abilities were improved, and depression levels were reduced. Anxiety was also improved.
Effects of Bioceramic Material and Colored Light Irradiation on Learning and Memory in Aging Rats.
Leung TK, Chen YC, Chao MW … +1 more , Tseng CY
Exp Aging Res · 2024 · PMID 37971779 · Publisher ↗
Aging is characterized by molecular damage from free radicals, leading to neural dysfunction and memory impairment. This study investigated using bioceramic material and colored light to mitigate neurodegenerative sympto...
Aging is characterized by molecular damage from free radicals, leading to neural dysfunction and memory impairment. This study investigated using bioceramic material and colored light to mitigate neurodegenerative symptoms in aging rats. We assessed the effects of different color light spectrums on D-galactose-induced aging rats using the Morris water maze, novel object recognition, and open field tests. Findings revealed that bioceramic material with various light wavelengths improved activity, recognition, and memory in aging rats. Significant enhancements were observed in the open field and novel object recognition tests, with a trend toward improvement in the Morris water maze. These effects are attributed to the antioxidant properties and microcirculation enhancement associated with bioceramic materials. Color stimulation may impact enzymes, human physiology, psychological activity, and the autonomic nervous system. This study highlights the significance of exploring novel interventions for neurodegenerative symptoms and memory deficits in aging rats. Results indicate that bioceramic material with different colored light spectrums positively influences cognitive function. These findings contribute to our understanding of the therapeutic potential of bioceramic materials and emphasize the need for further research in this area.
Effect of Autonomy and Physical Activity on Self-Rated Health of Older Adults in India: Gendered Analysis Using Structural Equation Models.
Vijayan B, Govil D, Sahoo H
Exp Aging Res · 2024 · PMID 37953538 · Publisher ↗
The gendered expectations and responsibilities placed upon women can impede their ability to participate in social activities and engage in physical leisure pursuits, ultimately having a negative impact on their health....
The gendered expectations and responsibilities placed upon women can impede their ability to participate in social activities and engage in physical leisure pursuits, ultimately having a negative impact on their health. Our study investigates the mechanisms through which gender influences individuals' engagement with physical activity during free time and how this relates to self-rated health outcomes among adults aged 45 years or older living in India. Using cross-sectional analysis and Structural Equation Modelling, we analyzed data stratified by gender and age from the Longitudinal Ageing Study of India to examine these conceptual pathways. We found that compared to men, women face greater limitations related to decision-making autonomy, experience more functional impairments, have weaker social networks that provide less support for engaging in leisure-time physical activity, leading them to report lower levels of overall wellbeing than men. Further analyses demonstrated distinct pathways through which each gender's level of social network connectivity shapes behavior - strong connections increase opportunities for women specifically to engage positively with both peers and physically active pursuits supporting overall wellness goals.
Does the Sensory Experience of Words Boost Recollection in Aging?
Bugaiska A, Witt A, Bonin P
Exp Aging Res · 2024 · PMID 37947178 · Publisher ↗
OBJECTIVES: We examine age-related differences in recollection and test the impact of words with high vs low sensory experience ratings (SER) in older and younger adults. We expected that the recollection of words with h...
OBJECTIVES: We examine age-related differences in recollection and test the impact of words with high vs low sensory experience ratings (SER) in older and younger adults. We expected that the recollection of words with high SER would be similar in older and young adults, as they depend on knowledge, unlike recollection of words with a low SER, which would depend on executive functions. METHODS: We manipulated the sensory experience of words (high vs. low) in encoding in young and older adults. The participants then took a word-recognition test using the Remember/Know paradigm (Gardiner, 1988). We also evaluated executive functions using several measures. RESULTS: Results show that the age-related difference in recollective experience was eliminated under the high SER encoding condition. Moreover, Remember (R) responses in the low SER condition seem to be related to executive functioning, unlike R responses in the high SER condition and Know (K) responses in both low and high SER conditions. DISCUSSION: Our study shows that the memory benefit of high-SER words is greater for older than younger adults. The study also supports the observation that older adults can compensate for their deficits by using sensory experience to consciously recollect information.
Age-Related Changes in the Utilization of Visual Information for Collision Prediction: A Study Using an Affordance-Based Model.
Sato K, Fukuhara K, Higuchi T
Exp Aging Res · 2024 · PMID 37942547 · Publisher ↗
The ability to predict collisions with moving objects deteriorates with aging. We followed the affordance-based model to identify optical variables that older adults had difficulty using for collision prediction. We repr...
The ability to predict collisions with moving objects deteriorates with aging. We followed the affordance-based model to identify optical variables that older adults had difficulty using for collision prediction. We reproduced a modified version of the interception task used in Steinmetz (Steinmetz, Layton, Powell, & Fajen, 2020, "Affordance-based versus current - future accounts of choosing whether to pursue or abandon the chase of a moving target," , 20(3), 8) in a virtual reality (VR) environment and newly introduced perturbation for each of three optical variables (vertical and horizontal expansions of a moving object and the bearing angle produced between participants and a moving object). We expected that perturbation would negatively affect the performance only for those who rely on the optical variable to perform the interception task effectively. We tested 18 older and 15 younger adults and showed that older participants were not negatively affected by the perturbation for the vertical and horizontal expansion of a moving object, while they showed decreased performance when the perturbation was introduced with a bearing angle. These findings suggest that predicting collisions with moving objects deteriorates with aging because the perception of object expansion is impaired with aging.
Effect of Perceptions of Future Time on Implicit and Explicit Memory in Older Adults.
Bugaiska A, Bonin P, Ferreira J … +1 more , Witt A
Exp Aging Res · 2024 · PMID 37936419 · Publisher ↗
OBJECTIVES: We examine age-related differences in implicit and explicit memory tasks, and test the impact of future time perspectives on priming and cued recall. METHODS: We induced time perspective in young (limited-tim...
OBJECTIVES: We examine age-related differences in implicit and explicit memory tasks, and test the impact of future time perspectives on priming and cued recall. METHODS: We induced time perspective in young (limited-time perspective) and older (extended-time perspective) adults. Implicit and explicit memory tasks were performed by younger and older adults. RESULTS: Results showed an age-related effect on priming and cued recall, confirming that implicit and explicit memory are impaired in aging. Nevertheless, manipulation of future time perspective eliminated age differences in priming and cued recall. DISCUSSION: These findings support the view that it is not age that determines memory performance but rather the perception of the time left to us. Socio-emotional selectivity theory thus seems to be a serious candidate to explain age-related differences in implicit and explicit memory.
Effects of Interviewer Age on the Reminiscence Bump in Older adults' Autobiographical Memories.
Sakata Y
Exp Aging Res · 2024 · PMID 37929932 · Publisher ↗
INTRODUCTION: This study aims to investigate whether the reminiscence bump in older adults' autobiographical memory is influenced by the interviewer's age. Methods: I arranged four interviewer. CONDITIONS: child, univers...
INTRODUCTION: This study aims to investigate whether the reminiscence bump in older adults' autobiographical memory is influenced by the interviewer's age. Methods: I arranged four interviewer. CONDITIONS: child, university student, middle-aged adult, and older adult. The participating older adults were asked individually to describe three memories and the age at which the event occurred. I analyzed the temporal distribution of the bumps and the recall order. RESULTS: The results indicate that the interviewer's age, especially the child interviewers were influenced the temporal location of the reminiscence bump. Conclusion: This study discusses the implications of these findings for older adults' social communication processes.
The Association of Social Support, Depression, and Loneliness with Health-Related Quality of Life in Over 50 Years Adults: Ardakan Cohort Study on Ageing (ACSA).
Delbari A, Akbarzadeh I, Saatchi M … +5 more , Tabatabaei FS, Bidkhori M, Abolfathi Momtaz Y, Mohseni-Bandpey R, Hooshmand E
Exp Aging Res · 2024 · PMID 37879966 · Publisher ↗
BACKGROUND AND AIM: Social factors play a crucial role in the quality of life of + 50 adults. This study aimed to investigate the association between social support, depression, and loneliness and the health-related qual...
BACKGROUND AND AIM: Social factors play a crucial role in the quality of life of + 50 adults. This study aimed to investigate the association between social support, depression, and loneliness and the health-related quality of life in + 50 adults of Ardakan. METHODS: This was a cross-sectional study from the first phase of Ardakan Cohort Study on Aging (ACSA) in 2019. Health-Related Quality of Life (HRQoL, SF-16), Duke Social Support Index (DSSI), and Center for Epidemiologic Studies Depression Scale (CES-D10) were used to assess the variables of interest. Multivariable linear regression was used to model the associated factors with the score of the SF-16 tool in two dimensions; physical (PCS) and mental (MCS). FINDINGS: A total of 5197 over 50 years individuals included in this study; The mean age was 62.2 ± 7.3 years old, and 52% were male. The mean score for PCS and MCS subscales was 45.6 (95% CI 45.4 to 45.9) and 49.3 (95% CI 49.0 to 49.5), respectively. Adjusted for other variables, having less feeling level of loneliness, and not having depressive symptoms were related to better PCS and MCS scores. CONCLUSION: The HRQoL for the mental aspect of HRQoL was better than the physical in elder populations. Also, much more focus should be paid to older adults who experience inadequate social support, higher levels of loneliness, and depressive symptoms.
Low 25-Hydroxyvitamin D [25(OH)D] Levels as a Predictor of Depressive Symptoms: Evidence from Community-Dwelling Older Adults Population in Mexico City.
Llanos-Becerra G, Dávila-Godínez E, Torres-Carrillo N … +4 more , Rosas-Carrasco O, Sandoval-Pinto E, Beltrán-Ramírez R, Torres-Carrillo NM
Exp Aging Res · 2024 · PMID 37830306 · Publisher ↗
OBJECTIVE: The purpose of this study was to assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and depressive symptoms in Mexican older adults 70 years and older. METHODS: A total of 326 adults age...
OBJECTIVE: The purpose of this study was to assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and depressive symptoms in Mexican older adults 70 years and older. METHODS: A total of 326 adults aged 70 or older from Coyoacán Cohort Study were included in this study. The depressive symptoms were assessing by Center for Epidemiologic Studies Depression Scale (CES-D) and serum 25-hydroxyvitamin D [25(OH)D] levels were measured by commercially available enzyme-linked immunosorbent assay (ELISA). RESULTS: Overall, the prevalence of depressive symptoms was 36.5%. The mean age was 79 years, and 53.4% were women. The total serum 25-hydroxyvitamin D [25(OH)D] levels were lower in older adults with depressive symptoms when compared with older adults without depressive symptoms ( = .006). Logistic regression models showed a significant association between low serum 25(OH)D levels and depressive symptoms even after adjusting for potential confounders (OR = 2.453; 95% CI:1.218-4.939; = .012). In addition, linear regression model to predict the effect of 25-hydroxyvitamin D [25(OH)D] levels on the CES-D score as a continuous variable, was statistically significant [F = 8.54, = .004], and the R-squared value was .026, indicating that this regression model explains 2.6% of the change in the CES-D score. CONCLUSION: These results suggest that older Mexican adults with lower serum 25-hydroxyvitamin D [25(OH)D] levels are at higher risk of presenting depressive symptoms.
Aging in 10 Minutes: Do Age Simulation Suits Mimic Physical Decline in Old Age? Comparing Experimental Data with Established Reference Data.
Gerhardy TH, Schlomann A, Wahl HW … +3 more , Mombaur K, Sloot LH, Schmidt LI
Exp Aging Res · 2024 · PMID 37702256 · Publisher ↗
INTRODUCTION: Age simulation suits are increasingly used in health care education. However, empirical evidence that quantifies the simulated performance losses in established geriatric tests and compares those declines w...
INTRODUCTION: Age simulation suits are increasingly used in health care education. However, empirical evidence that quantifies the simulated performance losses in established geriatric tests and compares those declines with reference data of older adults is scarce. METHODS: In a standardized lab setting, we compared performance of = 61 participants (46 middle-aged, 15 young adults) with and without age simulation suit, for example in the Timed Up and Go Test (+dual task), Short Physical Performance Battery, grip strength, and 30-Second-Chair- Standing Test. Additionally, we compared the results with suit to established reference values of older adults in different age groups. RESULTS: Reduced performance was observed in both groups when wearing the suit, yet to different degrees dependent on the assessment and user age. For one, larger declines were observed in more challenging and complex tasks across age groups. In addition, comparisons with reference values revealed age-differential "instant aging" effects. DISCUSSION: A simulated "fourth age," where frailty and impairments are accumulating, was not reached in the majority of assessments, especially not among younger participants. In conclusion, existing age simulation suits may have some educational and empathy potential, but so far, they fail in simulating the age period with most serious functional loss.
An Investigation of Affective Personality Traits in Alzheimer's Disease: SEEKING as a Possible Predictor for Early-Stage Alzheimer's Dementia.
Soncu Buyukiscan E, Yildirim E, Demirtas-Tatlidede A … +2 more , Bilgic B, Gurvit H
Exp Aging Res · 2024 · PMID 37695698 · Publisher ↗
OBJECTIVE: The aim of the current study was to investigate affective personality traits in Alzheimer's disease, a neurodegenerative condition mainly characterized by episodic memory impairment. METHOD: The sample include...
OBJECTIVE: The aim of the current study was to investigate affective personality traits in Alzheimer's disease, a neurodegenerative condition mainly characterized by episodic memory impairment. METHOD: The sample included 69 participants from 3 diagnostic categories. Twenty-five participants were diagnosed with subjective cognitive impairment (SCI), 26 participants were diagnosed with mild cognitive impairment of the amnestic type (aMCI), and the remaining 18 participants were diagnosed with early-stage Alzheimer's dementia (ADD). Diagnostic labels were given as a result of detailed neurological, neuropsychological, and neuroradiological assessment. Affective personality traits were assessed via Affective Neuroscience Personality Scales (ANPS). RESULTS: The only significant intergroup difference was obtained for the SEEKING subscale of ANPS. Here, ADD group scored significantly lower compared to the SCI group. The results of logistic regression analysis also indicated that SEEKING score successfully predicted early-stage ADD diagnosis. CONCLUSION: The results suggest that a specific personality constellation characterized by reduced investment in the outside world might be associated with Alzheimer's disease, either as a risk factor or a byproduct of the neurodegenerative process initiated by AD pathology.
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