Polski Merkuriusz Lekarski[JOURNAL]
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200 papers
Dynamics of indicators of cadets' daily motor activity in different training years.
Prontenko K, Bondarenko VV, Plisko VI … +4 more , Radzievskyi RM, Novitska IV, Nikitenko OV, Skoruy OS
Pol Merkur Lekarski · 2024 · PMID 39360724 · Publisher ↗
OBJECTIVE: Aim: The aim is to investigate the dynamics of indicators of daily motor activity of cadets of higher educational institutions with specific learning environment in different training years. PATIENTS AND METHO...
OBJECTIVE: Aim: The aim is to investigate the dynamics of indicators of daily motor activity of cadets of higher educational institutions with specific learning environment in different training years. PATIENTS AND METHODS: Materials and Methods: The research involved 226 cadets of the National Academy of Internal Affairs in the first (n = 62), second (n = 56), third (n = 60), and fourth (n = 48) training years. We used the Framingham method which involves the calculation of the motor activity index to determine the daily time spent on cadets' motor activity and their daily energy expenditure. RESULTS: Results: The dynamics of motor activity indicators of cadets in different training years have been studied. The best index were found in the third-year cadets (34.12 ± 0.49 points and 2643.9 ± 36.6 kcal), and the worst - in the first (32.68 ± 0.43 points and 2537 ± 33.9 kcal) and fourth (32.85 ± 0.41 points and 2550.9 ± 31.3 kcal). At the same time, a significant difference between the indicators of motor activity per day was found only in the first- and third-year cadets (p < 0.05). In general, the level of daily motor activity of the first- and fourth-year cadets is assessed as insufficient (inadequate), and of the secondand third-year cadets - as proper. CONCLUSION: Conclusions: The results obtained indicate the need to increase the daily level of motor activity of cadets by involving them in sporting and mass participation events and extracurricular physical exercises and increasing the intensity of physical training sessions.
The effect of enterosgel on the activity of energy supply processes in rats at the same time affected by malathion and tetrachlormethane.
Boiko L, Kachur O, Lykhatskyi P … +2 more , Fira D, Fira L
Pol Merkur Lekarski · 2024 · PMID 39360723 · Publisher ↗
OBJECTIVE: Aim: The aim of the study was to investigate the activity of bioenergetic processes in rats under conditions of simultaneous exposure to malathion and carbon tetrachloride and after the use of enterosgel. PATI...
OBJECTIVE: Aim: The aim of the study was to investigate the activity of bioenergetic processes in rats under conditions of simultaneous exposure to malathion and carbon tetrachloride and after the use of enterosgel. PATIENTS AND METHODS: Materials and Methods: Experiments were conducted on rats. The rats were divided into nine groups.Malathion was administered daily (for 30 days) at a dose of 20 mg / kg body weight of the animal. Tetrachloromethane was administered twice (every other day) as a 50% oil solution at a dose of 1.0 ml / kg body weight. The intensity of energy supply processes was assessed by the activity of succinate dehydrogenase and cytochrome oxidase, impaired carbohydrate metabolism in terms of glucose and glycogen. RESULTS: Results: It was noted that succinate dehydrogenase activity in the liver decreased 2 times, in the myocardium - 1.6 times. On the thirty and seventh day of administration of toxicants after enterosorbent use, succinate dehydrogenase activity increased in the liver by 20%, cytochrome oxidase by 27%, in the myocardium - by 31% and 23%, respectively. The content of glucose in the serum after exposure to toxicants increased maximally (2.4 times) at the end of the study. In contrast, the glycogen content in the liver decreased by 48%, in the myocardium by 13%. The use of enterosgel resulted in a decrease in serum glucose. CONCLUSION: Conclusions: The use of enterosgel leads to the restoration of energy processes in the body of affected rats, which is confirmed by increased activity of mitochondrial enzymes, lowering glucose and increasing glycogen in the studied organs.
Youth's internet dependence forming factors as a global public health problem.
Okhrimenko IМ, Okhrimenko SS, Marchuk AV … +4 more , Kudinov VA, Pakrysh OY, Tyurina VO, Liakhova N
Pol Merkur Lekarski · 2024 · PMID 39360722 · Publisher ↗
OBJECTIVE: Aim: The aim is to study the main factors of youth's Internet dependence formation. PATIENTS AND METHODS: Materials and Methods: We conducted psychodiagnostic examination of students in the National Academy of...
OBJECTIVE: Aim: The aim is to study the main factors of youth's Internet dependence formation. PATIENTS AND METHODS: Materials and Methods: We conducted psychodiagnostic examination of students in the National Academy of Internal Affairs. The research involved 154 students: full-time students aged 18-25 (n = 78) and part-time students aged 26-35 (n = 76). RESULTS: Results: The degree of prevalence of various types of Internet dependence among young people was determined. It was determined that the problem of Internet dependence requires consideration of socio-demographic, socio-psychological, individual, and psychological, as well as organizational factors. CONCLUSION: Conclusions: It was found that the number of Internet-dependent people among youth is currently growing rapidly. The most favorable individual-typological properties of a personality for the development of Internet dependence are introversion, anxiety, sensitivity, and aggressiveness. Internet dependence is a type of social dependence. An Internet-dependent individual suffers from the inability to maintain harmonious interpersonal contacts and resolve personal issues that are distorted by the virtual environment. Deviations from normal behavior in society change the peaceful way of life and affect public health.
Optimal tactics for surgical revascularisation in diabetic angiopathy of the lower limbs.
Zhakubayev M, Yegemberdiyev TZ, Tolegen AI … +1 more , Tajibayev T
Pol Merkur Lekarski · 2024 · PMID 39360721 · Publisher ↗
OBJECTIVE: Aim: This study aims to compare the efficacy of conservative treatment methods versus advanced surgical interventions, including revascularising automyelotransplantation and stem cell therapy, in improving vas...
OBJECTIVE: Aim: This study aims to compare the efficacy of conservative treatment methods versus advanced surgical interventions, including revascularising automyelotransplantation and stem cell therapy, in improving vascular patency and the quality of life in patients with diabetic angiopathy. PATIENTS AND METHODS: Materials and Methods: The research analyzed 68 patients with angiopathies under medical supervision from January 2007 to December 2017 at the National Scientific Center of Surgery named after A.N. Syzganov. Participants, aged 4 to 49, were divided into two groups based on angiographic blood flow characteristics: one with accelerated and another with delayed blood flow. A comprehensive participant selection process was implemented to ensure a representative sample. Sensitivity analysis was conducted to validate the findings' robustness. RESULTS: Results: The main group demonstrated notable success in limb salvage, with 90.9% avoiding high limb amputation post-revascularising automyelotransplantation. Moreover, 16.7% of patients experienced healing of trophic ulcers and toe necrosis. The use of stem cells from adipose tissue and fetal tissue progenitor cells showed promising results in reducing pain and increasing pain-free walking distance, alongside the formation of collateral vascular networks. CONCLUSION: Conclusions: The study concludes that advanced surgical interventions and stem cell therapies significantly enhance treatment outcomes in patients with diabetic angiopathy compared to conventional conservative treatments. These findings highlight the potential of personalized and innovative approaches in managing vascular complications associated with diabetes, offering new avenues for reducing disability and improving patient quality of life. Future research should focus on further refining these therapeutic strategies and exploring their integration into clinical practice.
Epidemiology and risk factors for healthcare-associated maternal peripartum infections in Ukraine: results a multicenter study.
Salmanov AG, Artyomenko VV, Shchedrov AO … +7 more , Prishchepa AP, Padchenko AS, Korniyenko SM, Kovalyshyn OA, Zarichanska KV, Nastradina NM, Kokhanov IV
Pol Merkur Lekarski · 2024 · PMID 39360720 · Publisher ↗
OBJECTIVE: Aim: To estimate the frequency of different types of healthcare-associated maternal peripartum infections and their risk factors among women in Ukraine. PATIENTS AND METHODS: Materials and Methods: Multicenter...
OBJECTIVE: Aim: To estimate the frequency of different types of healthcare-associated maternal peripartum infections and their risk factors among women in Ukraine. PATIENTS AND METHODS: Materials and Methods: Multicenter prospective cohort study was conducted in nine regional perinatal centers of Ukraine between January 1, 2021, to December 31, 2023. The criteria for specific healthcare-associated maternal peripartum infections (endometritis, episiotomy infection, and maternal sepsis) site were adapted from the CDC/NHSN case definitions. Surveillance was performed during the hospitalization period and up to 30 days after hospital discharge. RESULTS: Results: A total of 3600 deliveries by the vaginal route were performed during the study period, 600 (16.7%) maternal peripartum infections were observed. Of all maternal peripartum infection cases, 79.7% were detected after hospital discharge. The most common maternal peripartum infections include endometritis (54.8%), episiotomy infections (34.4%), and maternal sepsis (10.8%). According to the multivariate logistic regression analysis, the body mass index >25, placenta previa, premature rupture of membrane, prolonged rupture of membranes, manual removal of the placenta, multiple vaginal examinations, bacterial vaginosis, aerobic vaginitis, gestational diabetes mellitus, and anemia during pregnancy were independent risk factors for maternal peripartum infections. CONCLUSION: Conclusions: Results this study suggest a high prevalence of healthcare-associated maternal peripartum infections in Ukraine. Several factors have been associated with increased risk of maternal peripartum infections, including pre-existing maternal conditions, placenta previa, prolonged rupture of membranes, and spontaneous or provider-initiated conditions during labour and childbirth.
Immediate results of transcatheter aortic valve implantation.
Todurov M, Zelenchuk O, Khokhlov A … +4 more , Sudakevych S, Stan M, Press ZV, Todurov B
Pol Merkur Lekarski · 2024 · PMID 39360719 · Publisher ↗
OBJECTIVE: Aim: To assess, analyze and present early postoperative results of transcatheter aortic valve implantation in patients with aortic stenosis. PATIENTS AND METHODS: Materials and Methods: During the period from...
OBJECTIVE: Aim: To assess, analyze and present early postoperative results of transcatheter aortic valve implantation in patients with aortic stenosis. PATIENTS AND METHODS: Materials and Methods: During the period from 2017 to 2023, we examined in total 77 patients with severe aortic stenosis and high risk of surgery who were eligible for the TAVI procedure at the "Heart Institute Ministry of Health of Ukraine". RESULTS: Results: Before implantation, the mean and maximum aortic valve gradients were 53.7±19.1 mm Hg and 90.1±28.8 mm Hg, respectively. The mean and maximum aortic valve gradients after implantation were 9.67±3.18 and 18.7±6.41, respectively (p<0.001). The calculated left ventricular ejection fraction was 57.5±8.22% before surgery and 58.8±7.91% after surgery (p=0.412). After the procedure, moderate (2) degree of paravalvular aortic regurgitation was observed in 2 patients and light degree - in 21 patients. Before surgery, mitral regurgitation of 2-3 degrees was observed in 15 patients, and only in two patients after TAVI The survival rate of our patients was 96.4% after 180 days of supervision. In-hospital and 30-day mortality was 1.8%, while 180-day mortality was 3.6%. No deterioration was observed in patients with moderate aortic regurgitation during echocardiographic studies performed at 1, 3 and 6 months after TAVI. CONCLUSION: Conclusions: TAVI is rapidly emerging as a life-saving alternative for patients who are inoperable or at high risk of surgery due to comorbidities. The selection of patients for TAVI is important to optimize procedural and long-term outcomes. It is important for cardiologists in our country to refer patients with severe aortic stenosis after diagnosis to centers that perform TAVI.
Annual survival of patients with end-stage chronic kidney disease on supportive hemodialysis and its correlates.
Bodessova S, Sultanova B, Bekenova N … +1 more , Mursalova Z
Pol Merkur Lekarski · 2024 · PMID 39360718 · Publisher ↗
OBJECTIVE: Aim: The aim of the study was to determine the relationship of residual renal function, markers of inflammation and protein-energy expenditure with annual survival in patients undergoing hemodialysis. PATIENTS...
OBJECTIVE: Aim: The aim of the study was to determine the relationship of residual renal function, markers of inflammation and protein-energy expenditure with annual survival in patients undergoing hemodialysis. PATIENTS AND METHODS: Materials and Methods: The work was a prospective cohort study and included 299 patient data. Residual kidney function was determined by urine volume of more than 250 ml per day to assess the effect. According to this criterion, the patients were divided into two groups. The degree of chronic inflammation was assessed by the content of acute phase proteins (ferritin and C-reactive protein) in the blood serum. The serum albumin level was chosen as a marker of protein-energy expenditure. The survival rate of patients with residual renal function was higher as compared to patients without it (p<0.001). RESULTS: Results: In the current study, the absence of residual kidney function increased the risk of mortality from all causes in patients who had recently undergone hemodialysis by almost 30 times during the first year of substitution therapy. C-reactive protein was also associated with poorer survival in these patients (HR=1.01; 95% CI: 1-1.02), while albumin was inversely associated with mortality (HR=0.92; 95% CI: 0.87-0.98). CONCLUSION: Conclusions: Thus, residual renal function and higher serum albumin levels by the time maintenance hemodialysis begins are independent predictors of the best survival during the first year of replacement therapy. The presence of residual kidney function of less than 250 ml and a higher level of C-reactive protein correlated with an increased risk of mortality in these patients.
Special at-rich sequence-binding protein 2 and its role in healing of the experimental mandible bone tissue defect filling with a synthetic bone graft material and electrical stimulation impact.
Huseynov AN, Malanchuk VA, Myroshnychenko MS … +3 more , Kapustnyk NV, Sukharieva LP, Selivanova LI
Pol Merkur Lekarski · 2024 · PMID 39360717 · Publisher ↗
OBJECTIVE: Aim: The purpose of the study was to identify the role of SATB2 in healing of the experimental mandible bone tissue defect filling with a synthetic bone graft material and electrical stimulation impact. PATIEN...
OBJECTIVE: Aim: The purpose of the study was to identify the role of SATB2 in healing of the experimental mandible bone tissue defect filling with a synthetic bone graft material and electrical stimulation impact. PATIENTS AND METHODS: Materials and Methods: An experiment was carried out on 48 mature male rats of the WAG population, which were divided into 4 groups. Each group included 12 experimental animals. Group 1 included rats that were modeled with a perforated defect of the lower jaw body. Group 2 included animals that were modeled with a perforated defect similar to group 1. In animals, a microdevice for electrical action was implanted subcutaneously in the neck area on the side of the simulated bone defect. The negative electrode connected to the negative pole of the battery was in contact with the bone defect. The battery and electrode were insulated with plastic heat shrink material. Group 3 included rats that were modeled with a perforated defect similar to previous groups, the cavity of which was filled with synthetic bone graft "Biomin GT" (RAPID, Ukraine). Group 4 included animals that were modeled with a perforated defect similar to groups 1-3, the cavity of which was filled with synthetic bone graft "Biomin GT" (RAPID, Ukraine). The simulation of electrical stimulation was the same as in group 2. The material for the morphological study was a fragment of the body of the lower jaw from the zone of the perforated defect. Immunohistochemical study was performed using rabbit anti-human SATB2 monoclonal antibody. RESULTS: Results: In the regenerate filling the defect in the bone tissue of the lower jaw of rats, there was an increase in SATB2 expression under conditions of electrical stimulation; filling the defect with a synthetic bone graft material; simultaneous filling the defect with a synthetic bone graft material and electrical stimulation. The most pronounced expression of SATB2 was observed under conditions of simultaneous filling the defect with a synthetic bone graft material and electrical stimulation; minimally expressed - in conditions of filling the defect with a synthetic bone graft material; moderately expressed - under conditions of electrical stimulation. In the regenerate, in cases of all treatment methods, SATB2 was expressed by immune cells, fibroblastic differon cells, osteoblasts, and in case of electrical stimulation, also by adipocytes, vascular pericytes and endothelial cells, epidermis. CONCLUSION: Conclusions: The activation of SATB2 expression identified by the authors is one of the mechanisms for stimulating reparative osteogenesis under the conditions of electrical stimulation; filling the defect with a synthetic bone graft material; simultaneous filling the defect with a synthetic bone graft material and electrical stimulation.
Maintaining the mental health of Ukrainians in time of war: searching for a mechanism to provide a comprehensive system of psychosocial support and mental health awareness.
Vus VI, Shkoliar MV, Proskuriakov S … +1 more , Fradelos E
Pol Merkur Lekarski · 2024 · PMID 39007478 · Publisher ↗
OBJECTIVE: Aim: To substantiate the possibilities of developing a comprehensive system of psychosocial support for Ukrainians during and after the war through thedevelopment of an integrated model of psychosocial service...
OBJECTIVE: Aim: To substantiate the possibilities of developing a comprehensive system of psychosocial support for Ukrainians during and after the war through thedevelopment of an integrated model of psychosocial service provision in the community, which promotes cross-sectoral interaction and expands the possibilities of integrating and scaling up multiple levels of mental health interventions. PATIENTS AND METHODS: Materials and Methods: The article is based on the use of bibliosemantic analysis of scientific works on the topic of mental health and mental health during the war. CONCLUSION: Conclusions: It is emphasised that in developing a comprehensive system of psychosocial support, it is necessary to: ensure accessibility of services for those in need; integrate services into the general health and social protection system; use a multisectoral approach, involving various organisations, institutions and professionals; train professionals to work in war conditions; develop and implement psychoeducation and psychological support programmes; monitor and evaluate the effectiveness of programmes. Particular attention is paid to psychoeducation as a technology that can be used at different levels of psychological intervention by both mental health professionals and other specialists involved in the provision of social services in communities. The spread of the impact of psychoeducational programmes will contribute to the development of community resilience in the face of social and psychological risks provoked by the war. A mechanism for scaling up the capabilities of the Technical Working Group on Mental Health and Psychosocial Support (MHPSS TWG), an association of leading international and Ukrainian NGOs specialising in mental health, established in Ukraine with the support of the WHO and the Ministry of Health of Ukraine, is proposed. The idea of creating a network of Resilience Centres in communities with the aim of forming a comprehensive system of psychosocial support at the state and community levels is substantiated.
Fast resolution of mild midvetricular takotsubo syndrome triggered by blunt chest trauma: case study.
Elikowski W, Szczęśniewski P, Fertała N … +3 more , Zawodna-Marszałek M, Baszko A, Żytkiewicz M
Pol Merkur Lekarski · 2024 · PMID 39007477 · Publisher ↗
Blunt chest trauma (BCT) may rarely trigger stress-induced takotsubo syndrome (TTS) which requires dif f erential diagnosis with myocardial contusion and BCT-induced myocardial infarction. So far reported cases have been...
Blunt chest trauma (BCT) may rarely trigger stress-induced takotsubo syndrome (TTS) which requires dif f erential diagnosis with myocardial contusion and BCT-induced myocardial infarction. So far reported cases have been presented as apical ballooning or inverted (reverse) TTS forms but not as a midventricular variant. The authors described a case of a 53-year-old female admitted to Intensive Care Unit after motor vehicle accident with BCT and airbag deployment during car roll over. For some time after the accident, she was trapped in a car with her head bent to the chest. After being pulled out from the car, she had impaired consciousness and therefore was intubated by the rescue team. Trauma computed tomography scan did not reveal any injuries. However, ECG showed ST-segment depression in II, III, aVF, V4-6, and discrete ST-segment elevation in aVR. Troponin I and NTpro-BNP increased to 2062 ng/l and 6413 pg/ml, respectively. Echocardiography revealed mild midventricular dysfunction of the left ventricle with ejection fraction (EF) and global longitudinal strain (GLS) reduced to 45% and -17.6%, respectively. On day two, the patient's general condition improved and stabilized, so she was extubated. Normalization of ECG, EF and GLS (but not regional LS) was observed on day three. She was discharged home on day fi ve. Post-hospital examinations documented that segmental longitudinal strain remained abnormal for up to 4 weeks. The authors conclude that fast ECG and echocardiographic evolution may result in underestimation of the posttraumatic TTS diagnosis, especially if it takes atypical form and its course is mild. Longitudinal strain evaluation can be helpful in cardiac monitoring of trauma patients.
Pityriasis Rubra Pilaris - a difficult path to optimal treatment. Case report.
Smyk J, Kamińska A, Borowy P … +3 more , Major P, Gołojuch K, Batko B
Pol Merkur Lekarski · 2024 · PMID 39007476 · Publisher ↗
Pityriasis Rubra Pilaris is a rare, chronic inflammatory dermatosis of unknown etiology, presenting with erythema and papular eruptions. Treatment is difficult due to the lack of causal therapy, guidelines and requires a...
Pityriasis Rubra Pilaris is a rare, chronic inflammatory dermatosis of unknown etiology, presenting with erythema and papular eruptions. Treatment is difficult due to the lack of causal therapy, guidelines and requires an individualized approach. The most common treatments are systemic retinoids, immunosuppressants, phototherapy and biological therapy. This article presents the case of a 73-year-old man suffering from type 1 pityriasis rubra pilaris. The patient was initially treated with acitretin, which was discontinued due to hypogammaglobulinemia. This rare side effect of acitretin has not been previously published. As a second-line treatment, the patient received methotrexate, but with no clinical improvement after 3 months and an increase in skin pruritus. Finally, the use of isotretinoin resulted in significant clinical improvement and was well tolerated.
Comparative analysis of the influence of the shapes and dimensions of dental arches on the morphotopogeometric characteristics of the facial area.
Potapchuk A, Almashi V, Horzov A … +1 more , Kostenko S
Pol Merkur Lekarski · 2024 · PMID 39007475 · Publisher ↗
OBJECTIVE: Aim: The aim of the article is a comparative analysis of the main aspects of existing medical and diagnostic measures in patients with abnormal types of occlusal relationships and methods of mathematical and g...
OBJECTIVE: Aim: The aim of the article is a comparative analysis of the main aspects of existing medical and diagnostic measures in patients with abnormal types of occlusal relationships and methods of mathematical and graphic reproduction of the shape of the dental arches, taking into account the individual characteristics of the maxillofacial area. PATIENTS AND METHODS: Materials and Methods: The search for relevant publications related to the objective topic was carried out through scientific databases: Scopus, PubMed, BVS and Scielo. CONCLUSION: Conclusions: The analysis of regression models of the reproduction of individual characteristics of the dental arch of the jaws will avoid errors that occur when comparing the actual sizes with their statistical norm, which will allow to correctly determine the proportionality and ratio of dif f erent departments of the dental and jaw system, the necessary amount of orthodontic measures in the treatment of anomalies of the dental arches.
Analytical review of the inf l uence of socio-economic factors on the state of pharmaceutical care for patients with cardiovascular diseases.
Bilousova NA, Mykhalchuk VM
Pol Merkur Lekarski · 2024 · PMID 39007474 · Publisher ↗
OBJECTIVE: Aim: To investigate the influence of socio-economic factors on the state of pharmaceutical provision of patients with cardiovascular diseases. PATIENTS AND METHODS: Materials and Methods: To achieve the goal o...
OBJECTIVE: Aim: To investigate the influence of socio-economic factors on the state of pharmaceutical provision of patients with cardiovascular diseases. PATIENTS AND METHODS: Materials and Methods: To achieve the goal of the research, scientific publications posted in Ukrainian information and scientific databases (NRAT, OUCI) and scientometric databases Scopus, Web of Science, PubMed, MedLine, BMJ, Embase were used. The analysis of international and domestic legal documents was carried out, the sites of global international organizations, the sites of cardiology societies and Ukrainian statistical data bases were researched. The methods of content analysis, synthesis, systematization, and generalization were used. CONCLUSION: Conclusions: As a result of the study, socio-economic factors that af f ect the state of pharmaceutical provision of patients with CVD (in particular, CAD) were determined. In this study, among the specif i ed socio-economic factors, the need to update the regulatory and legal security of the pharmaceutical care process attracts the most of attention. The positive impact of the use of modern drug pharmacotherapy for coronary artery disease on the budget of the health care system in clinical practice proposed by the ESC was determined.
A review on the current approaches and perspectives of Covid-19 treatment.
Dobrek Ł
Pol Merkur Lekarski · 2024 · PMID 39007473 · Publisher ↗
At the beginning of 2020, the world was faced with the challenge of the coronavirus disease 2019 (COVID-19) pandemic announced by the WHO on March 11, caused by the betacoronavirus type 2 of the severe acute respiratory...
At the beginning of 2020, the world was faced with the challenge of the coronavirus disease 2019 (COVID-19) pandemic announced by the WHO on March 11, caused by the betacoronavirus type 2 of the severe acute respiratory syndrome (SARS-CoV-2), which had profound health, sociological and even economic consequences. The quickly implemented and large-scale research resulted in the introduction of widely available vaccines that reduced the further development of the pandemic and antivirals against SARS-CoV-2. Currently, 11 antiviral drugs (Tixagevimab/Cilgavimab, Regdanvimab, Casirivimab/Imdevimab, Sotrovimab, Nirmatrelvir/Ritonavir, Remdesivir, Molnupiravir, Baricitinib, Anakinra, Tocilizumab, Vilobelimab) have been approved or conditionally approved by the European Medicines Agency and/or by the Food and Drug Administration and are available on the pharmaceutical market. The progress in the pathophysiological description of the SARS-CoV-2 infection has allowed the identif i cation of potential targets for drugs against SARS-CoV-2: inhibitors of intracellular entry of the virus (the interaction between the viral spike (S) protein and the cellular angiotensin converting enzyme-2; ACE2 receptor), inhibitors of viral and cellular proteases, and immunomodulatory drugs (antagonists of pro-inf l ammatory cytokines or complement components). Novel agents against SARS-CoV-2 are also sought among the previously routinely used drugs as their repositioning and among plant-derived compounds. It is expected that ongoing research should result in the introduction of new drugs used in COVID-19 in the near future. The article brief l y describes the current epidemiological situation regarding COVID-19 and the currently used vaccines. Moreover, the paper outlines currently used and researched potential drugs in the pharmacotherapy of this disease.
Impact of modulators of nitric oxide synthesis on the level of cytokines in bronchoalveolar lavage in experimental antiphospholipid syndrome.
Mekhno N, Hlyvka N, Furka O … +4 more , Ruzhytska O, Kulitska M, Kuzmak I, Yaremchuk O
Pol Merkur Lekarski · 2024 · PMID 39007472 · Publisher ↗
OBJECTIVE: Aim: The aim of the research is to study the cytokine prof i le (IL-1β, IL 6, TNF-α, IL-4, IL-10) in bronchoalveolar lavage of lungs in experimental APS and its correction with L-arginine and aminoguanidine. P...
OBJECTIVE: Aim: The aim of the research is to study the cytokine prof i le (IL-1β, IL 6, TNF-α, IL-4, IL-10) in bronchoalveolar lavage of lungs in experimental APS and its correction with L-arginine and aminoguanidine. PATIENTS AND METHODS: Materials and Methods: Antiphospholipid syndrome was modeled on white female BALB/c mice. L-arginine (25 mg/kg) and aminoguanidine (10 mg/kg) were used for its correction. The concentration of cytokines in bronchoalveolar lavage from the lungs was assessed using the ELISA test. RESULTS: Results: It was established that in cases of APS the concentration of proinf l ammatory cytokines IL-1β, IL-6 and TNF-a increased in 1.9, 2.3 and 6.6 times, respectively, compare to the control. At the same time a decrease of the IL-4 in 1.7 and IL-10 in 1.8 times was found in the APS group compare to the control. L-arginine reduced the level of proinf l ammatory cytokines IL-1β by 22%, IL-6 - by 36%, and TNF-α - by 23% compare to the animals with APS. At the same time, the level of anti-inf l ammatory cytokines increased: IL-4 - by 46%, IL-10 - by 57% compare to the APS animal group. Aminoguanidine, a selective iNOS inhibitor, did not cause any signif i cant decrease in pro-inf l ammatory cytokines but the level of anti-inf l ammatory cytokines IL-4 increased by 44% and IL-10 - by 49%. CONCLUSION: Conclusions: The precursor of the NO synthesis L-arginine leads to a decrease in the concentrations of IL-1β, IL-6, TNF-a and an increase of IL-4 and IL-10 compare to the group of BALB/c mice with APS.
Peculiarities of students' mental functions development under the influence of different physical activities.
Griban G, Khoroshukha MF, Lyakhova NA … +4 more , Biletska VV, Yefimenko PB, Kanishcheva OP, Zhlobo TM
Pol Merkur Lekarski · 2024 · PMID 39007471 · Publisher ↗
OBJECTIVE: Aim: The aim is to study the influence of the training activities of different orientations on the attention development of student specializing in different sports. PATIENTS AND METHODS: Materials and Methods...
OBJECTIVE: Aim: The aim is to study the influence of the training activities of different orientations on the attention development of student specializing in different sports. PATIENTS AND METHODS: Materials and Methods: The study involved 127 students, who were divided into three groups: group A (n=68) was engaged in speed and power sports, group B (n=59) was engaged in endurance sports, the control group (n=83) included peer students who did not do sports during their studies. The research on students' attention was carried out according to Anfimov's test using a table with letters. RESULTS: Results: It was revealed that speed and power activities increase the integrated indicator of attention (the coefficient of work performance) based only on the speed of viewing characters with unreliable changes in the correctness of the work indicators. Under the influence of endurance training, the coefficient of efficiency is increased based on both an increase in the speed of viewing characters and the correctness of the work indicators. The students of the control group were found to have insignificant changes in the studied indicators of attention. CONCLUSION: Conclusions: This suggests that endurance training promotes the development of students' attention more ef f ectively. It is set, that specifics of the training process, its orientation equally specifically specialize the peculiarities of the attention development of students.
Motivational orientations of students towards internet dependent behavior and measures for its prevention.
Okhrimenko IM, Okhrimenko SS, Yarovyi KV … +4 more , Melnykov IM, Kudinov VA, Marchenko OG, Bordiyan YІ
Pol Merkur Lekarski · 2024 · PMID 39007470 · Publisher ↗
OBJECTIVE: Aim: The aim is to study the motivation of students towards Internet dependent behavior and develop practical recommendations for improving a set of measures for its prevention. PATIENTS AND METHODS: Materials...
OBJECTIVE: Aim: The aim is to study the motivation of students towards Internet dependent behavior and develop practical recommendations for improving a set of measures for its prevention. PATIENTS AND METHODS: Materials and Methods: The research involved 154 students of the National Academy of Internal Affairs. Research methods: analysis and generalization of literature sources, questionnaire, statistical methods. RESULTS: Results: The priority motives of students who manifest Internet dependence behavior were identif i ed. The motivational orientations of students determine their systematic stay in the virtual environment and include, first of all, compliance with modern world trends; accessibility of content; the need for recognition of personal results by other users; satisfaction with virtual communication with the social environment. CONCLUSION: Conclusions: The practical recommendations for improving a set of measures to counteract the spread of Internet dependence among students were developed. Overcoming Internet dependence involves influencing a person to change his or her motivational and value as well as communication spheres. Prevention of Internet dependence involves public health professionals conducting awareness-raising as well as psychological and correctional work with the most vulnerable categories of people.
Development and validation of a questionnaire to evaluate attitudes and beliefs of discrimination by nursing staff.
Daratsianou M, Fradelos EC, Spyridakis MS … +2 more , Prezerakos P, Tzavella F
Pol Merkur Lekarski · 2024 · PMID 39007469 · Publisher ↗
OBJECTIVE: Aim: The purpose of this study is to report on the development and initial psychometric testing of a questionnaire to investigate nurses' discrimination attitudes and beliefs towards people of dif f erent ethn...
OBJECTIVE: Aim: The purpose of this study is to report on the development and initial psychometric testing of a questionnaire to investigate nurses' discrimination attitudes and beliefs towards people of dif f erent ethnic origins. PATIENTS AND METHODS: Materials and Methods: The initial stage involved the selection of the questions of the tool after a comprehensive evaluation of the relevant international literature and the tools used in previous related studies. The reliability (forward-backward translation) of the questions was assessed, along with the content, face, and structure. To conduct the study, which was carried out from 07/2021 to 01/2022 a sample consisting of 30 and 2,034 nurses and their assistants was used for the pilot and the fi nal research, respectively. RESULTS: Results: Given that the Kaiser-Meyer-Olkin (KMO) threshold value of 0.89 was achieved, the sample was considered sufficient and appropriate for factor analysis. A statistically signif i cant result (p<0.001) from Bartlett's test indicated a substantial connection between the questions and conf i rmed that the data were suitable for factor analysis. Twenty statements altogether, with seven possible answers ranging from "totally disagree" to "completely agree," were included in the questionnaire. For the questions, three distinct factors - communication, difficulties, and discrimination - were shown to account for 47.1% of the variability. Reliability analyzes showed satisfactory Cronbach alpha coefficient scores for all factors, ranging from 0.78 to 0.82. CONCLUSION: Conclusions: The current study demonstrates that the questionnaire we developed is a legitimate and trustworthy instrument for evaluating professional nurses' discriminatory attitudes and beliefs toward individuals from various ethnic backgrounds. The questionnaire can be used to help design interventions to end discrimination, guarantee equitable access to healthcare services, and provide high-quality care for individuals from diverse backgrounds. It can also be used to identify the factors that inf l uence nurses' attitudes and perceptions toward these patient populations.
Determination of dysbiosis by the method of multiplex real-time polymerase chain reaction in chronic catarrhal gingivitis in children.
Polishchuk TV, Sheshukova OV, Mosiienko AS … +3 more , Trufanova VP, Bauman SS, Kazakova KS
Pol Merkur Lekarski · 2024 · PMID 39007468 · Publisher ↗
OBJECTIVE: Aim: The aim of the study was to determine the quantitative and qualitative characteristics of the microbiota of dento-gingival plaque in children to improve the quality of treatment of chronic catarrhal gingi...
OBJECTIVE: Aim: The aim of the study was to determine the quantitative and qualitative characteristics of the microbiota of dento-gingival plaque in children to improve the quality of treatment of chronic catarrhal gingivitis. PATIENTS AND METHODS: Materials and Methods: It was examined 16 children aged 9-16 years with a diagnosis of K05.1: chronic gingivitis and 10 persons with intact gums were taken as a comparison group. A clinical dental examination was performed on the study participants and a sample was taken to determine the bacteria in the periodontal plaque. RESULTS: Results: The results of statistical processing of the research data allowed us to establish that in patients with chronic gingivitis, quantitative indicators of the total bacterial mass, Lactobacillus spp., Enterobacteriaceae, Gardnerella vaginalis/Prevotella bivia/Porphyromonas spp. in the sample of periodontal plaque significantly exceeded the indicators of healthy patients. It was determined that the examined children with chronic gingivitis, the total number of Lactobacillus spp. significantly exceeds its amount in people with intact gums. CONCLUSION: Conclusions: The changes in the quantitative and qualitative characteristics of the main representatives of the microf i lm of dento-gingival plaque, which characterize dysbiosis, are of signif i cant clinical signif i cance. Study of the quantitative characteristics of Lactobacterium spp., Enterobacterium spp., Streptococcacea spp., Gardnerella spp., Prevotella spp., Porphyromonas spp., Eubacteridacea spp., Mycoplasma (hominis + genitalium), Candida spp. is a diagnostic factor in determining the condition of the mucous membrane of the oral cavity.
Peculiarities of physical therapy of chronic obstructive pulmonary disease: practical experience.
Zhamardiy VO, Kletsenko LV, Vyshar YV … +4 more , Harkusha SV, Donchenko V, Hordiienko OV, Voronetskyi VB
Pol Merkur Lekarski · 2024 · PMID 39007467 · Publisher ↗
OBJECTIVE: Aim: The aim of the study is todetermine the feasibility of using a home pulmonary rehabilitation program and evaluate its impact on patients with COPD in the GOLD B group. PATIENTS AND METHODS: Materials and...
OBJECTIVE: Aim: The aim of the study is todetermine the feasibility of using a home pulmonary rehabilitation program and evaluate its impact on patients with COPD in the GOLD B group. PATIENTS AND METHODS: Materials and Methods: The study was conducted on the basis of the «Healthy Movements» studio (Poltava). Patients were involved in the study after receiving secondary (specialized) medical care, the basis of which was physical therapy treatment and exercise therapy in accordance with the clinical protocol approved by the internal order of the health care institution. A total of 30 people (aged 59 to 68.4 years) with II degree chronic obstructive pulmonary disease (50 % ≤ FEV1 < 80 % of normal) in remission took part in the study. Research methods: pedagogical, medical and biological , methods of mathematical statistics. RESULTS: Results: Each patient confirmed the achievement of the general goal, namely, increasing the number of therapeutic exercises from 3 to 5 times a week, improving the quality of life, more active participation in improving their health and awareness of the disease. The patients considered self-management training to be the most valuable. CONCLUSION: Conclusions: Pulmonary rehabilitation is indicated for all patients, regardless of the degree of the disease. The most ef f ective are 6-12 week programs that include breathing exercises, self-management training and training of the patient's environment, strengthening exercises, psychological support, diet therapy.
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